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1. Al Sanosi A, Fagan PA, Biggs ND: Conservative management of acoustic neuroma. Skull Base; 2006 May;16(2):95-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of acoustic neuroma.
  • AIM OF STUDY: To identify those patients with vestibular schwannoma (acoustic neuroma) in whom treatment becomes necessary.
  • RESULT: A total of 205 patients with small tumors were followed for a mean of 40.8 months.
  • In 136 patients (66.3%) the tumor did not grow.
  • Eight of 197 patients (4%) had rapid growth and 6 patients (3%) had radiological evidence of tumor regression.
  • Five of these showed rapid growth, four developed ataxia in whom tumor growth was slow, three had ataxia without tumor growth, two patients developed brainstem compression, and one patient elected to proceed to surgery, although there were no tumor growth or symptoms.
  • CONCLUSION: Few patients with small tumors will come to surgery in the short term.
  • Perhaps the majority of patients with such small tumors will not need surgery.
  • Long-term follow-up studies of 20 years or more are required to be come more confident about the natural history of these tumors.

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  • (PMID = 17077873.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1502035
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2. Aznmi MN, Lokman BS, Ishlah L: The translabyrinthine approach for acoustic neuroma and its common complications. Med J Malaysia; 2006 Mar;61(1):72-5
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  • [Title] The translabyrinthine approach for acoustic neuroma and its common complications.
  • A retrospective analysis of 15 cases intracanalicular acoustic neuroma that undergone tumour excision by translabyrinthine approach spanning from August 1996 until December 2002 is presented.
  • Magnetic resonance imaging is the most important investigation tool to diagnose acoustic neuroma.
  • At six months post operatively, the facial nerve was normal or near normal (grade I and II) in 46.6%, grade III to IV in 46.6% and grade V to VI in 6.7% of the cases respectively.
  • [MeSH-major] Ear, Inner / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16708737.001).
  • [ISSN] 0300-5283
  • [Journal-full-title] The Medical journal of Malaysia
  • [ISO-abbreviation] Med. J. Malaysia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Malaysia
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3. Takebayashi T, Akiba S, Kikuchi Y, Taki M, Wake K, Watanabe S, Yamaguchi N: Mobile phone use and acoustic neuroma risk in Japan. Occup Environ Med; 2006 Dec;63(12):802-7
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  • [Title] Mobile phone use and acoustic neuroma risk in Japan.
  • To examine the relation between mobile phone use and acoustic neuroma, a case-control study was initiated.
  • One hundred and one acoustic neuroma cases, who were 30-69 years of age and resided in the Tokyo area, and 339 age, sex, and residency matched controls were interviewed using a common computer assisted personal interview system.
  • RESULTS: Fifty one cases (52.6%) and 192 controls (58.2%) were regular mobile phone users on the reference date, which was set as one year before the diagnosis, and no significant increase of acoustic neuroma risk was observed, with the odds ratio (OR) being 0.73 (95% CI 0.43 to 1.23).
  • No exposure related increase in the risk of acoustic neuroma was observed when the cumulative length of use (<4 years, 4-8 years, >8 years) or cumulative call time (<300 hours, 300-900 hours, >900 hours) was used as an exposure index.
  • CONCLUSIONS: These results suggest that there is no significant increase in the risk of acoustic neuroma in association with mobile phone use in Japan.
  • [MeSH-major] Cell Phones. Neoplasms, Radiation-Induced / etiology. Neuroma, Acoustic / etiology

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  • [CommentIn] Occup Environ Med. 2008 Jun;65(6):428; author reply 428 [18487430.001]
  • (PMID = 16912083.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2078004
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4. Koh ES, Millar BA, Ménard C, Michaels H, Heydarian M, Ladak S, McKinnon S, Rutka JA, Guha A, Pond GR, Laperriere NJ: Fractionated stereotactic radiotherapy for acoustic neuroma: single-institution experience at The Princess Margaret Hospital. Cancer; 2007 Mar 15;109(6):1203-10
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  • [Title] Fractionated stereotactic radiotherapy for acoustic neuroma: single-institution experience at The Princess Margaret Hospital.
  • BACKGROUND: The clinical outcome and toxicity of fractionated stereotactic radiotherapy (FSRT) was assessed for acoustic neuroma in 60 patients treated in a single institution.
  • METHODS: Between October 1996 and February 2005, 60 patients received FSRT for acoustic neuroma (AN).
  • The median irradiated tumor volume was 4.9 cm(3) (range, 0.3-49.0 cm(3)).
  • Five of 6 patients with initial cranial nerve V (CNV) numbness remained stable post-FSRT.
  • All 3 patients with nonsurgically related facial nerve weakness either improved or achieved stability in function.
  • There were no cases of new cranial nerve toxicity post-FSRT.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 17318817.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Wandong S, Meng L, Xingang L, Yuguang L, Shugan Z, Lei W, Chengyuan W: Cystic acoustic neuroma. J Clin Neurosci; 2005 Apr;12(3):253-5
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  • [Title] Cystic acoustic neuroma.
  • To define the clinical characteristics of cystic acoustic neuroma, we retrospectively analyzed 22 patients with cystic acoustic neuroma and reviewed the literature with regard to clinical manifestation, imaging features, diagnosis, surgical procedures and prognosis.
  • An acoustic neuroma was defined as cystic according to the following criteria: the presence of hypodense/hypointense areas on CT or MRI, the identification of cystic elements at operation and histological verification.
  • At the end of surgery, the facial nerve was anatomically intact in 86.4% of cystic acoustic neuromas.
  • Complete removal of the tumor was achieved in 18 cases (81.8%).
  • We conclude that patients with cystic acoustic neuroma need prompt surgery with special attention paid to the preservation of the facial nerve.
  • [MeSH-major] Neuroma, Acoustic / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Facial Nerve / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Prognosis. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 15851076.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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6. Boisson-Bertrand D, Laxenaire MC, Mertes PM: Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane. Anaesth Intensive Care; 2006 Jun;34(3):338-42
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  • [Title] Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane.
  • In this study, 33 patients were randomly assigned to receive desflurane (D) or isoflurane (I) for acoustic neuroma surgery.
  • The results indicate that desflurane is associated with similar operating conditions and faster postoperative recovery following acoustic neuroma surgery.
  • [MeSH-major] Anesthesia Recovery Period. Anesthesia, Inhalation. Anesthetics, Inhalation. Isoflurane / analogs & derivatives. Neuroma, Acoustic / surgery

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  • (PMID = 16802487.001).
  • [ISSN] 0310-057X
  • [Journal-full-title] Anaesthesia and intensive care
  • [ISO-abbreviation] Anaesth Intensive Care
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; CRS35BZ94Q / desflurane; CYS9AKD70P / Isoflurane
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7. Kalogeridi MA, Georgolopoulou P, Kouloulias V, Kouvaris J, Pissakas G: Long-term results of LINAC-based stereotactic radiosurgery for acoustic neuroma: the Greek experience. J Cancer Res Ther; 2009 Jan-Mar;5(1):8-13
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  • [Title] Long-term results of LINAC-based stereotactic radiosurgery for acoustic neuroma: the Greek experience.
  • PURPOSE: To estimate the value of LINAC-based stereotactic radiosurgery (SRS) for the long-term local control of unilateral acoustic neuromas.
  • MATERIALS AND METHODS: Twenty patients (median age 66; range 57-80 years) with unilateral acoustic neuroma underwent LINAC-based SRS from May 2000 through June 2004 with a dose of 11-12 Gy.
  • The follow-up consisted of repeat imaging studies and clinical examination for assessment of facial and trigeminal nerve function at 6-month intervals for the first year and yearly thereafter.
  • RESULTS: Eleven tumors (58%) decreased in size and eight (42%) remained stable.
  • One tumor showed a minor increase in size on the MRI done 6 months after SRS in comparison with the pretreatment MRI; however, a subsequent decrease was noticed on the next radiographic assessment and the tumor remained stable from then on.
  • None of the tumors increased in size in the long-term follow-up, thus giving an overall growth control of 100% for the patients in this study.
  • CONCLUSION: LINAC-based SRS with 11-12 Gy provides excellent tumor control in acoustic neuroma and has low toxicity even after long-term follow-up.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 19293482.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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8. del Río L, Lassaletta L, Alfonso C, Sarriá MJ, Gavilán J: [Clinical tumoral size dissociation in acoustic neuroma: reality or measure distortion?]. Acta Otorrinolaringol Esp; 2006 Oct;57(8):345-9
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  • [Title] [Clinical tumoral size dissociation in acoustic neuroma: reality or measure distortion?].
  • [Transliterated title] Disociación clínica-tamaño tumoral en el neurinoma del acúistico: realidad o problema de medida?
  • INTRODUCTION: In this study we have analyzed (i) the audiometric frequencies more often affected in acoustic neuroma (AN), (ii) the percentage of patients presenting normal hearing and those with sudden hearing loss, (iii) if there is a correlation between tumor size and hearing loss, and (iv) the relationship between clinical and radiological parameters and audiological data.
  • RESULTS: The highest threshold in the tumor's ear was found at 8000 Hz, and the highest interaural difference at 4000 Hz.
  • No significant association was found between tumor size and hearing loss, preoperative facial palsy or Vth cranial nerve deficit.
  • There was a significant association between the degree of hearing loss and Vth cranial nerve deficit, and between hearing loss and preoperative facial palsy.
  • CONCLUSIONS: The association between hearing loss and Vth cranial nerve deficit, and between hearing loss and preoperative facial palsy is independent the size of the tumour.
  • [MeSH-major] Hearing Loss / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 17117690.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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9. Rhoton AL Jr, Tedeschi H: Microsurgical anatomy of acoustic neuroma. 2002. Neurosurg Clin N Am; 2008 Apr;19(2):145-74, v
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  • [Title] Microsurgical anatomy of acoustic neuroma. 2002.
  • This article reviews the microsurgical anatomy important to preserving the involved cranial nerves and adjacent neural and vascular structures during acoustic neuroma removal.
  • These anatomic considerations are divided into sections dealing with the relationships at the lateral end of the tumor in the meatus and those on the medial end of the tumor at the brain stem.
  • The anatomy of the region offers the opportunity for three approaches to the tumor in the meatus and cerebellopontine angle.
  • [MeSH-major] Microsurgery / history. Neuroma, Acoustic / history

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  • (PMID = 18534333.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Rhoton AL Jr; Tedeschi H
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10. Orabi AA, D'Souza AR, Walsh RR, Irving RM: The influence of the Internet on decision making in acoustic neuroma. J Laryngol Otol; 2005 Oct;119(10):806-9
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  • [Title] The influence of the Internet on decision making in acoustic neuroma.
  • OBJECTIVE: To determine the access to and the use of the Internet by acoustic neuroma patients as a medical information source, and the influence of the Internet on decision-making, as well as the patients' views on the quality of particular sites.
  • MATERIALS AND METHODS: A retrospective 27-item questionnaire was sent to 138 consecutive acoustic neuroma patients diagnosed between 1997 and 2002.
  • Twenty-four per cent accessed the Internet to obtain information about acoustic neuromas.
  • Acoustic neuroma specialists and ENT surgeons in general should familiarize themselves with related websites so that patients can then be directed to high-quality sites.
  • [MeSH-major] Decision Making. Information Services / utilization. Internet / utilization. Neuroma, Acoustic / therapy

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  • (PMID = 16259658.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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11. Chang SD, Gibbs IC, Sakamoto GT, Lee E, Oyelese A, Adler JR Jr: Staged stereotactic irradiation for acoustic neuroma. Neurosurgery; 2005 Jun;56(6):1254-61; discussion 1261-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Staged stereotactic irradiation for acoustic neuroma.
  • OBJECTIVE: Stereotactic radiosurgery has proven effective in the treatment of acoustic neuromas.
  • Prior reports using single-stage radiosurgery consistently have shown excellent tumor control, but only up to a 50 to 73% likelihood of maintaining hearing at pretreatment levels.
  • Staged, frame-based radiosurgery using 12-hour interfraction intervals previously has been shown by our group to achieve excellent tumor control while increasing the rate of hearing preservation at 2 years to 77%.
  • The arrival of CyberKnife (Accuray, Inc., Sunnyvale, CA) image-guided radiosurgery now makes it more practical to treat acoustic neuroma with a staged approach.
  • In this retrospective study, we report our experience with staged radiosurgery for managing acoustic neuromas.
  • METHODS: Since 1999, the CyberKnife has been used to treat more than 270 patients with acoustic neuroma at Stanford University.
  • Among the treated patients, the mean transverse tumor diameter was 18.5 mm, whereas the total marginal dose was either 18 or 21 Gy using three 6- or 7-Gy fractions.
  • Only one treated tumor (2%) progressed after radiosurgery; 29 (48%) of 61 decreased in size and 31 (50%) of the 61 tumors were stable.
  • In no patients did new trigeminal dysfunction develop, nor did any patient experience permanent injury to their facial nerve; two patients experienced transient facial twitching that resolved in 3 to 5 months.
  • CONCLUSION: Although still preliminary, these results indicate that improved tumor dose homogeneity and a staged treatment regimen may improve hearing preservation in acoustic neuroma patients undergoing stereotactic radiosurgery.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods

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  • (PMID = 15918941.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
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12. Mazzoni A, Dubey SP, Poletti AM, Colombo G: Sporadic acoustic neuroma in pediatric patients. Int J Pediatr Otorhinolaryngol; 2007 Oct;71(10):1569-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sporadic acoustic neuroma in pediatric patients.
  • OBJECTIVE: Sporadic acoustic neuroma, usually occur between the ages of 40 and 70 years, are very rare in children.
  • We review the experiences of 10 cases of sporadic (non-NF2) acoustic neuromas in pediatric patients.
  • Among these almost 900 cases were acoustic neuromas.
  • The diameter of the tumors varied widely with minimum of 10 mm to maximum up to 60 mm.
  • Five patients each underwent resection of the tumor by translabyrinthine and retrosigmoid approach, respectively.
  • Postoperatively seven cases the facial nerve recovered to grade I, and one each to grade II and grade VI of House-Brackmann classification.
  • The youngest patient with largest tumor diameter of 60 mm developed transient hemiparesis in the immediate postoperative period and he recovered fully in due course.
  • CONCLUSION: We found preservation of facial nerve function is more easier than hearing in this group of patients.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

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  • (PMID = 17643497.001).
  • [ISSN] 0165-5876
  • [Journal-full-title] International journal of pediatric otorhinolaryngology
  • [ISO-abbreviation] Int. J. Pediatr. Otorhinolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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13. Xue B, Yang J: [The characteristics of VEMP in patients with acoustic neuroma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Jan;22(1):22-5
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  • [Title] [The characteristics of VEMP in patients with acoustic neuroma].
  • OBJECTIVE: To establish the normal value of the vestibular evoked myogenic potential (VEMP), and to determine the characteristics of VEMP in patients with acoustic neuroma (AN) and to explore the significance of VEMP in diagnosis of AN.
  • VEMP was investigated in 14 patients with AN who underwent surgery during the period of 2006-2007 as well as auditory brainstem response (ABR) and vestibular caloric test.
  • [MeSH-major] Evoked Potentials, Auditory. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Acoustic Stimulation. Adult. Case-Control Studies. Electromyography. Female. Humans. Male. Middle Aged. Vestibular Function Tests. Young Adult

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  • (PMID = 18338565.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Lin D, Hegarty JL, Fischbein NJ, Jackler RK: The prevalence of "incidental" acoustic neuroma. Arch Otolaryngol Head Neck Surg; 2005 Mar;131(3):241-4
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  • [Title] The prevalence of "incidental" acoustic neuroma.
  • OBJECTIVE: To estimate the prevalence of "incidental" acoustic neuromas (ANs) in the population at large.
  • DESIGN: An intracranial magnetic resonance imaging (MRI) database of 46 414 patients presenting to the University of California, San Francisco (UCSF), without known audiovestibular complaints was searched retrospectively from July 1995 to February 2003.
  • A medical chart review of 688 patients with acoustic neuromas presenting to UCSF between 1980 and 1999 was searched for sex distribution.
  • Tumor size in this population ranged from 3 to 28 mm.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. California / epidemiology. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Humans. Male. Middle Aged. Prevalence. Prognosis. Registries. Retrospective Studies. Risk Assessment. Severity of Illness Index. Sex Distribution. Survival Rate

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  • (PMID = 15781765.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Jackler RK, Pitts LH: Selection of surgical approach to acoustic neuroma. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):217-38, vi
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  • [Title] Selection of surgical approach to acoustic neuroma. 1992.
  • A variety of surgical approaches are available in the management of acoustic neuroma.
  • Each procedure has certain advantages and disadvantages in terms of surgical exposure, the capability of preserving cranial nerve function, and postoperative morbidity.
  • This article advocates tailoring the operative approach to each acoustic neuroma according to its size, location, and clinical manifestations.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history

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  • (PMID = 18534336.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Jackler RK; Pitts LH
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16. Edwards CG, Schwartzbaum JA, Lönn S, Ahlbom A, Feychting M: Exposure to loud noise and risk of acoustic neuroma. Am J Epidemiol; 2006 Feb 15;163(4):327-33
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  • [Title] Exposure to loud noise and risk of acoustic neuroma.
  • Exposure to occupational loud noise has been previously identified as a possible risk factor for acoustic neuroma in only one relatively small (n = 86 cases) case-control study of men.
  • The goal of the present study was to further examine the role of loud noise in acoustic neuroma etiology.
  • In their population-based case-control study of both sexes conducted from 1999 to 2002 in Sweden, the authors compared reports on type and duration of occupational and nonoccupational loud noise exposure of 146 acoustic neuroma cases and 564 controls.
  • The authors found that individuals reporting loud noise exposure from any source were at increased risk for acoustic neuroma (odds ratio (OR) = 1.55, 95% confidence interval (CI): 1.04, 2.30).
  • Exposure to loud noise from machines, power tools, and/or construction increased the risk for acoustic neuroma (OR = 1.79, 95% CI: 1.11, 2.89), as did exposure to loud music (OR = 2.25, 95% CI: 1.20, 4.23).
  • The findings of an increased risk of acoustic neuroma with loud noise exposure support previous research.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology. Noise / adverse effects

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  • [CommentIn] Am J Epidemiol. 2006 Oct 1;164(7):706; author reply 706-7 [16943265.001]
  • [ErratumIn] Am J Epidemiol. 2006 Jun 15;163(12):1163
  • (PMID = 16357108.001).
  • [ISSN] 0002-9262
  • [Journal-full-title] American journal of epidemiology
  • [ISO-abbreviation] Am. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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17. Horner KC, Cazals Y: Stress hormones in Ménière's disease and acoustic neuroma. Brain Res Bull; 2005 Jul 15;66(1):1-8
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  • [Title] Stress hormones in Ménière's disease and acoustic neuroma.
  • We investigated stress hormones in Ménière's patients and patients with acoustic neuroma.
  • We found a strong positive correlation between cortisol and adrenocorticotropic hormone in Ménière patients and patients with acoustic neuroma but no correlation in patients with facial spasm.
  • The data also revealed in female patients with Ménière's disease or with acoustic neuroma an unexpected significant positive correlation between cortisol and prolactin.
  • Both cortisol and prolactin increases are known to represent alternative strategies to cope with stress, and our data point to prolactin being possibly more dominant in Ménière's disease and cortisol in acoustic neuroma.
  • [MeSH-major] Hormones / blood. Meniere Disease / blood. Neuroma, Acoustic / blood. Stress, Physiological / blood

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  • (PMID = 15925138.001).
  • [ISSN] 0361-9230
  • [Journal-full-title] Brain research bulletin
  • [ISO-abbreviation] Brain Res. Bull.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Hormones; 9002-60-2 / Adrenocorticotropic Hormone; 9002-62-4 / Prolactin; 9002-72-6 / Growth Hormone; WI4X0X7BPJ / Hydrocortisone
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18. Prochazka M, Feychting M, Ahlbom A, Edwards CG, Nise G, Plato N, Schwartzbaum JA, Forssén UM: Occupational exposures and risk of acoustic neuroma. Occup Environ Med; 2010 Nov;67(11):766-71
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  • [Title] Occupational exposures and risk of acoustic neuroma.
  • OBJECTIVES: Acoustic neuroma is a benign tumour accounting for approximately 6-10% of all intracranial tumours and occurs mainly in patients aged ≥50 years.
  • Our aim was to investigate a wide range of occupational exposures, individual occupational titles and socioeconomic status (SES) as potential risk factors for acoustic neuroma.
  • METHODS: We conducted a population-based case-control study of 793 acoustic neuroma cases identified through the Swedish Cancer Registry and 101,762 randomly selected controls.
  • We found no convincing evidence that SES is related to disease development.
  • CONCLUSION: We observed an increased risk of acoustic neuroma associated with occupational exposure to mercury, benzene and textile dust.
  • Men working as truck and conveyor operators <10 years before the reference year had the highest increased risk of acoustic neuroma, but it is unclear what in those occupations might contribute to disease development.
  • Our study also suggested an association between acoustic neuroma and being a class teacher or policeman.
  • [MeSH-major] Neuroma, Acoustic / etiology. Occupational Diseases / etiology

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  • (PMID = 20581419.001).
  • [ISSN] 1470-7926
  • [Journal-full-title] Occupational and environmental medicine
  • [ISO-abbreviation] Occup Environ Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dust; FXS1BY2PGL / Mercury; J64922108F / Benzene
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19. Chen S, Xu Y, Ou Y, Zheng Y, Deng Y, Chen B: [Endoscope-assisted surgical resection of acoustic neuroma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;22(16):729-31
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  • [Title] [Endoscope-assisted surgical resection of acoustic neuroma].
  • OBJECTIVE: To explore the therapeutic efficacy and complications of endoscope-assisted surgical resection of acoustic neuroma.
  • METHOD: Assisted by hard-tube ear endoscope, 11 patients with acoustic neuroma were operated via labyrinthine approach and retrosigmoid approach.
  • CONCLUSION: The application of ear endoscope in acoustic neuroma surgery can improve the total removal rate of tumors and the salvage rate of vessels and nerves.
  • [MeSH-major] Endoscopy. Neuroma, Acoustic / surgery

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  • (PMID = 18975773.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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20. Zanetti D, Campovecchi CB, Pasini S, Nassif N: Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation. Auris Nasus Larynx; 2008 Dec;35(4):562-8
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  • [Title] Simultaneous translabyrinthine removal of acoustic neuroma and cochlear implantation.
  • OBJECTIVES: To report of a 65-year-old woman with bilateral Meniere's disease was referred for cochlear implantation (CI) due to severe/profound sensorineural hearing loss.
  • METHODS: During the assessment workup, a vestibular schwannoma in the right ear was found by MR imaging.
  • She underwent a translabyrinthine removal of the acoustic neuroma (AN) with sparing of the cochlear nerve and concurrent ipsilateral CI with a Nucleus Freedom device (Cochlear Ltd., Lane Cove, New South Wales, Australia).
  • CONCLUSION: Cochlear implantation at the time of acoustic neuroma removal with VIII nerve sparing can be a safe and effective hearing restoration procedure.
  • [MeSH-major] Cochlear Implantation. Hearing Loss, Sensorineural / surgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Aged. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Meniere Disease / diagnosis. Speech Discrimination Tests


21. Rimaaja T, Haanpää M, Blomstedt G, Färkkilä M: Headaches after acoustic neuroma surgery. Cephalalgia; 2007 Oct;27(10):1128-35
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  • [Title] Headaches after acoustic neuroma surgery.
  • Headache and depression were studied in patients who had undergone operation for acoustic neuroma.
  • Headache after acoustic neuroma operation appears to be a specific subgroup of postcraniotomy headache.
  • [MeSH-major] Craniotomy / adverse effects. Headache / classification. Headache / etiology. Neuroma, Acoustic / surgery. Postoperative Complications

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  • (PMID = 17711494.001).
  • [ISSN] 0333-1024
  • [Journal-full-title] Cephalalgia : an international journal of headache
  • [ISO-abbreviation] Cephalalgia
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
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22. Gal TJ, Shinn J, Huang B: Current epidemiology and management trends in acoustic neuroma. Otolaryngol Head Neck Surg; 2010 May;142(5):677-81
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  • [Title] Current epidemiology and management trends in acoustic neuroma.
  • OBJECTIVE: The objective of this study was to assess the epidemiology of acoustic neuroma and determine current trends in therapy using tumor registry techniques.
  • SUBJECTS AND METHODS: The Surveillance Epidemiology and End Results (SEER) database is a national tumor registry that began to identify and abstract benign and borderline tumors of the brain and central nervous system in the year 2004.
  • Coding for International Classification of Diseases for Oncology (ICD-O-3) codes for schwannoma (9560/0) with collaborative staging (CS) coding for acoustic nerve (72.4) was used to identify acoustic neuromas.
  • Demographic data, tumor size, and treatment data were analyzed.
  • RESULTS: A total of 1621 patients with acoustic neuroma were identified, for an incidence rate of 1.1/100,000.
  • Tumors were equally distributed across gender and tumor laterality, with the majority (84%) occurring in Caucasians.
  • Of tumors less than 2 cm, 27.2 percent were treated with radiotherapy.
  • Statistically significant associations were observed with the increased use of radiotherapy for small (< 2 cm) tumors (P = 0.0001).
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / therapy


23. Magliulo G, D'Amico R, Celebrini A, Cuiuli G: Postoperative Ramsay-Hunt syndrome after acoustic neuroma resection. Viral reactivation. An Otorrinolaringol Ibero Am; 2005;32(3):253-9
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  • [Title] Postoperative Ramsay-Hunt syndrome after acoustic neuroma resection. Viral reactivation.
  • The aim of this paper is to present a patient suffering from acoustic neuroma and operated on with immediate postoperative hearing and facial function preservation who developed delayed Ramsay-Hunt syndrome.
  • [MeSH-major] Herpes Zoster Oticus / etiology. Herpes Zoster Oticus / virology. Neuroma, Acoustic / surgery. Postoperative Complications

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  • (PMID = 16001695.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antiviral Agents; X4HES1O11F / Acyclovir
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24. Zverina E: [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management]. Cas Lek Cesk; 2010;149(6):269-76
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  • [Title] [Acoustic neuroma--vestibular schwannoma--personal experience of up-to-date management].
  • [Transliterated title] Neurinom akustiku--vestibulární schwannom--osobní pohled na nejmodernejsí postupy v jeho lécbe.
  • Acoustic neuroma, properly called vestibular schwannoma, arises from the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve as the most frequent tumour of the posterior fossa.
  • Its incidence is estimated at 1.2 vestibular schwannoma per a population of 100,000/year.
  • As to size, vestibular schwannoma is classified into grades I to IV.
  • About one third of small vestibular schwannoma show hardly any growth, the larger ones grow aggressively.
  • The author's conclusion is based on 33 years of experience with hundreds of surgically treated vestibular schwannoma (now at the ENT Department of Head and Neck Surgery, CU 1st Medical Faculty and FN Teaching Hospital, Prague Motol).
  • Irradiation for larger vestibular schwannoma is decreasingly efficacious.
  • 3. Microsurgery with intraoperative monitoring of facial and acoustic nerve function offers scope for radical removal of vestibular schwannoma of any size (grades I-IV) and for the preservation of facial nerve function and, of late, hearing, too.
  • [MeSH-major] Neuroma, Acoustic

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  • (PMID = 20662473.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Czech Republic
  • [Number-of-references] 50
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25. Kondziolka D, Lunsford LD: Future perspectives in acoustic neuroma management. Prog Neurol Surg; 2008;21:247-54
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  • [Title] Future perspectives in acoustic neuroma management.
  • Management options for patients with vestibular schwannomas (acoustic neuromas) include observation, resection, stereotactic radiosurgery, or fractionated radiotherapy.
  • There has been an evolution in available technologies, and an evolution in both patient and physician approaches to the management of this tumor.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / trends

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  • (PMID = 18810226.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 65
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26. Parsa AT: Acoustic neuroma. Preface. Neurosurg Clin N Am; 2008 Apr;19(2):xi-xii
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  • [Title] Acoustic neuroma. Preface.
  • [MeSH-major] Neuroma, Acoustic / history

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  • (PMID = 18534332.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Editorial; Historical Article; Introductory Journal Article
  • [Publication-country] United States
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27. Lunsford LD: Foreword. Acoustic neuroma. Prog Neurol Surg; 2008;21:XI-XV
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Foreword. Acoustic neuroma.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 19004132.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Introductory Journal Article
  • [Publication-country] Switzerland
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28. Shaffer BT, Cohen MS, Bigelow DC, Ruckenstein MJ: Validation of a disease-specific quality-of-life instrument for acoustic neuroma: the Penn Acoustic Neuroma Quality-of-Life Scale. Laryngoscope; 2010 Aug;120(8):1646-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Validation of a disease-specific quality-of-life instrument for acoustic neuroma: the Penn Acoustic Neuroma Quality-of-Life Scale.
  • OBJECTIVES/HYPOTHESIS: To design and validate the first disease-specific quality-of-life instrument for acoustic neuroma, the Penn Acoustic Neuroma Quality-of-Life (PANQOL) scale.
  • METHODS: One hundred forty-three patients with acoustic neuromas completed the 80-question preliminary instrument and the general Short Form-36 Health Survey (SF-36).
  • PANQOL face domain scores showed significant differences across the House-Brackmann grading system scores and correlated inversely with tumor size.
  • The PANQOL scale discriminated acoustic neuroma cases from controls better than the SF-36.
  • CONCLUSIONS: We have developed the first validated disease-specific quality of life instrument for patients with acoustic neuromas.
  • Given the lack of a validated equivalent, this tool has the potential to become a critical outcome measure for studies evaluating treatment of patients with acoustic neuromas.
  • [MeSH-major] Health Status Indicators. Neuroma, Acoustic / diagnosis. Quality of Life

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  • (PMID = 20641085.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] United States
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29. Cafer S, Bayramoglu I, Uzum N, Yilmaz M, Memis L, Uygur K: Expression and clinical significance of Ki-67, oestrogen and progesterone receptors in acoustic neuroma. J Laryngol Otol; 2008 Feb;122(2):125-7
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  • [Title] Expression and clinical significance of Ki-67, oestrogen and progesterone receptors in acoustic neuroma.
  • OBJECTIVE: The objective was to assess the presence of Ki-67, and oestrogen and progesterone hormone receptors as well as their clinical correlates in acoustic neuroma.
  • METHODS: Medical records of 59 patients who were operated on for acoustic neuroma between 1995 and 2003 were evaluated retrospectively.
  • Formaldehyde-fixed paraffin-embedded archival acoustic neuroma specimens of the patients were used for immunohistochemical assessments of oestrogen and progesterone hormone receptors, and Ki-67 proliferative marker.
  • CONCLUSION: Oestrogen is not an important hormone in acoustic neuroma due to the absence of oestrogen receptor expression in the tissue samples.
  • Since the progesterone receptor is expressed in all acoustic neuroma samples, further studies are necessary to find out about the inhibitory effect of antiprogesterone treatment on acoustic neuroma growth, which may be important particularly in elderly people or high-risk patients.
  • Although Ki-67 is expressed in the majority of acoustic neuromas, it is not an important marker in clinical practice due to a lack of any correlation with the clinical parameters.
  • [MeSH-major] Biomarkers, Tumor / chemistry. Ki-67 Antigen / metabolism. Neuroma, Acoustic / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Nucleus / metabolism. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Male. Middle Aged. Retrospective Studies

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  • (PMID = 17666143.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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30. Salahaldin AH, Bener A: Long-term and frequent cellular phone use and risk of acoustic neuroma. Int Tinnitus J; 2006;12(2):145-8
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  • [Title] Long-term and frequent cellular phone use and risk of acoustic neuroma.
  • Human exposure to radio frequency radiation has increased dramatically during recent years from widespread use of mobile phones, and in some studies this exposure has been linked to the development of acoustic neuroma.
  • The aim of our study was to describe the epidemiology of acoustic neuroma in a newly developed country, Qatar.
  • We reviewed all cases of acoustic neuroma registered at the Hamad Medical Corporation during the period 2004-2005.
  • During the study period, we diagnosed acoustic neuroma in 13 patients (10 women, median age 55 years, and 3 men, median age 49 years).
  • Most of the cell phones were used daily for an average of 14 times per day (range, 8-20 times) and had been used for the duration of more than 5 years, with the exception of 3 patients who had used the cell phone excessively (> 20 minutes per call more than five times daily) owing to the nature of their jobs.
  • In conclusion, the incidence of acoustic neuroma in Qatar is slightly higher than that in other countries.
  • [MeSH-major] Cell Phones / utilization. Neuroma, Acoustic / etiology

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  • (PMID = 17260880.001).
  • [ISSN] 0946-5448
  • [Journal-full-title] The international tinnitus journal
  • [ISO-abbreviation] Int Tinnitus J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Tufarelli D, Meli A, Labini FS, Badaracco C, De Angelis E, Alesii A, Falcioni M, Sanna M: Balance impairment after acoustic neuroma surgery. Otol Neurotol; 2007 Sep;28(6):814-21
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  • [Title] Balance impairment after acoustic neuroma surgery.
  • OBJECTIVE: The aim of this study was to assess the incidence of balance problems after acoustic neuroma surgery, evaluating whether disequilibrium is disabling.
  • PATIENTS: A group of 386 patients who underwent acoustic neuroma surgery.
  • INTERVENTIONS: Patients were selected from a population of 459 subjects who had undergone surgery for acoustic neuroma.
  • CONCLUSION: Disequilibrium influences handicap and disability after acoustic neuroma surgery.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology. Postural Balance / physiology. Vestibulocochlear Nerve Diseases / complications. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Disability Evaluation. Dizziness / physiopathology. Female. Humans. Male. Middle Aged. Surveys and Questionnaires. Vestibular Function Tests

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  • (PMID = 17948359.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Scarlett A, Bird P, Macfarlane M: Conductive hearing loss after removal of acoustic neuroma. Otol Neurotol; 2008 Jun;29(4):553-6
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  • [Title] Conductive hearing loss after removal of acoustic neuroma.
  • OBJECTIVE: To report 4 patients who have developed a conductive and/or mixed hearing loss due to dehiscence of the inner ear after retrosigmoid approach for removal of acoustic neuroma.
  • PATIENTS: Four patients who presented with conductive and/or mixed hearing loss after retrosigmoid approach for removal of acoustic neuroma.
  • CONCLUSION: The occurrence of conductive hearing loss after the surgical removal of an acoustic neuroma has not previously been documented.
  • Computed tomographic scan of the temporal bones showing inner ear dehiscence may explain this finding.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / surgery. Hearing Loss, Conductive / etiology. Hearing Loss, Conductive / physiopathology. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology. Vestibulocochlear Nerve Diseases / complications. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Acoustic Impedance Tests. Adult. Aged. Audiometry. Female. Hearing Aids. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Otologic Surgical Procedures. Otoscopy. Petrous Bone / pathology. Speech Perception. Tomography, X-Ray Computed


33. Douglas SA, Yeung P, Daudia A, Gatehouse S, O'Donoghue GM: Spatial hearing disability after acoustic neuroma removal. Laryngoscope; 2007 Sep;117(9):1648-51
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  • [Title] Spatial hearing disability after acoustic neuroma removal.
  • OBJECTIVES/HYPOTHESIS: Previous studies on hearing loss (HL) after acoustic neuroma removal concentrate mainly on pure-tone hearing results rather than hearing disability.
  • Our objectives were to use the Speech, Spatial and Qualities of Hearing scale (SSQ), a comprehensively validated questionnaire, to characterize and quantify the auditory disabilities that patients experience with a profound unilateral HL after acoustic neuroma removal.
  • STUDY DESIGN: Forty-four patients with profound unilateral HL after acoustic neuroma surgery completed the SSQ.
  • RESULTS: In comparison with controls, with use of analysis of variance, acoustic neuroma patients scored poorly on all items except for the identification of sounds and objects (P = .123).
  • [MeSH-major] Hearing Loss, Unilateral / etiology. Neuroma, Acoustic / surgery. Postoperative Complications

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  • (PMID = 18062043.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / K24 AR02098; United States / NIADDK NIH HHS / AM / N01 AM62271; United States / NIAMS NIH HHS / AR / N01 AR22200; United States / NIAMS NIH HHS / AR / N01 AR22201; United States / NIAMS NIH HHS / AR / N01 AR72233
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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34. Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Inskip PD: Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol; 2007 Jan 1;165(1):63-71
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  • [Title] Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults.
  • Risks for brain tumors are not well understood.
  • The authors investigated associations between use of synthetic hair dyes and risk of brain tumors in a hospital-based case-control study.
  • The study included adults newly diagnosed with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96) between 1994 and 1998 at three urban US hospitals and 799 controls.
  • There was no consistent pattern of elevated odds ratios for glioma, meningioma, or acoustic neuroma with use or prolonged use of permanent, semipermanent, temporary, or gradual hair dyes.
  • Although use of permanent brown hair dye for 20 or more years was associated with glioma among women, the estimate was imprecise (odds ratio = 3.8, 95% confidence interval: 1.2, 12.5) and was based on just 13 exposed cases; thus, this could be a chance finding.
  • Overall, there was little consistent evidence for an association of synthetic hair dye use with glioma, meningioma, or acoustic neuroma.
  • [MeSH-major] Brain Neoplasms / epidemiology. Environmental Exposure / adverse effects. Glioma / epidemiology. Hair Dyes / toxicity. Meningioma / epidemiology. Neuroma, Acoustic / epidemiology


35. Lei T, Li L: [Prevention of facial nerve injury in acoustic neuroma microsurgery]. Zhonghua Wai Ke Za Zhi; 2008 Jan 1;46(1):58-60
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  • [Title] [Prevention of facial nerve injury in acoustic neuroma microsurgery].
  • OBJECTIVE: To summarize and analyse the techniques of avoiding facial nerve injury during acoustic neuroma microsurgery.
  • METHODS: One hundred and eighty patients with large acoustic neuroma (> or =4 cm) and 70 patients with medium acoustic neuroma (2.4-4.0 cm) were diagnosed by MRI/ CT scan before operation and confirmed by postoperative pathologic examination.
  • All of patients were treated by sub-occipital retrosigmoid approach for tumor removal and facial nerve reservation during operation.
  • The relationships among the bone, arachnoid, nerve and vascular anatomy were particularly observed during the operation.
  • After decompression of the tumor, the origination and location of the facial nerve as well as the relationship between the tumor and the facial nerve should be identified.
  • The patients were followed-up from 6 months to 1 year postoperatively and assessed by House-Brackmann facial nerve function grading system.
  • RESULTS: Total tumor resection was achieved in 240 of 250 cases (96%) and subtotal in 10 cases including 1 case died because of cerebellar encephalomalacia after operation.
  • According to the House-Brackmann facial nerve function grading, recovery of normal function (grade I) was achieved in 214 cases (85.6%), grade II in 25 cases (10%), grade III in 5 cases (2.09%) and grade IV in 5 cases (2.09%).
  • CONCLUSION: Microneurosurgical techniques are helpful for total resection of acoustic neuroma and keeping facial nerve anatomic intact.
  • [MeSH-major] Facial Nerve Injuries / prevention & control. Intraoperative Complications / prevention & control. Microsurgery / methods. Neuroma, Acoustic / surgery

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  • (PMID = 18510007.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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36. Wiet RJ, Kazan RP, Ciric I, Littlefield PD: Acoustic neuroma (vestibular schwannoma) revision. Otolaryngol Clin North Am; 2006 Aug;39(4):751-62, vii
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  • [Title] Acoustic neuroma (vestibular schwannoma) revision.
  • The authors present their experience of more than 25 years, now in excess of 1200 patients, with cerebellopontine angle tumors.
  • This article focuses on the management of planned subtotal resection of acoustic tumors in five subjects, and unexpected "residual" discovered by MRI scanning in 10 cases, which represents, to the best of the authors' knowledge, a residual rate of 1% of operated patients.
  • The rate of residual tumor is as high as 19% in some series and, in part, depends on the surgical approach.
  • For the purpose of this article, the authors did not include their cases of neurofibromatosis, because these tumors behave differently than unilateral sporadic schwannomas.
  • [MeSH-major] Neuroma, Acoustic / surgery
  • [MeSH-minor] Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm, Residual. Reoperation. Retrospective Studies. Time Factors. Treatment Outcome

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  • (PMID = 16895783.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Naguib MB, Cokkeser Y, Sanna M: Management of acoustic neuroma in the only hearing ear. Eur Arch Otorhinolaryngol; 2005 Feb;262(2):127-30
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  • [Title] Management of acoustic neuroma in the only hearing ear.
  • Patients with acoustic neuroma in their only hearing ear are not frequently seen in clinical practice.
  • In this study we report on five cases of acoustic neuroma in an only hearing ear.
  • Our decision for conservative management of those patients with regular follow-up using auditory brain stem response and magnetic resonance imaging is discussed.
  • [MeSH-major] Ear Neoplasms / complications. Ear Neoplasms / surgery. Hearing Loss, Unilateral / complications. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery

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  • (PMID = 15747105.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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38. Day AS, Wang CT, Chen CN, Young YH: Correlating the cochleovestibular deficits with tumor size of acoustic neuroma. Acta Otolaryngol; 2008 Jul;128(7):756-60
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  • [Title] Correlating the cochleovestibular deficits with tumor size of acoustic neuroma.
  • CONCLUSION: The tumor size of acoustic neuroma correlates with cochleovestibular deficits.
  • Those tumors with global frequency hearing loss, bilateral gaze nystagmus, or absent caloric and VEMP responses may indicate a tumor size >2.5 cm.
  • OBJECTIVE: This study aimed to investigate the correlation between cochleovestibular deficits and the size of acoustic neuroma.
  • PATIENTS AND METHODS: A total of 44 patients with acoustic neuroma were enrolled in this study.
  • Pure tone audiometry, electronystagmography, caloric test, vestibular evoked myogenic potential (VEMP) test, and MRI were conducted.
  • RESULTS: There is a trend of correlation between tumor size and audiographic configuration, with small-sized tumor in normal and rising types, medium-sized tumor in mid- and high-frequency hearing loss, and large-sized tumor in flat and deafness types.
  • Five patients with bilateral gaze nystagmus had significantly larger tumor size than those without nystagmus.
  • When 1 and 0 are used to represent abnormal and normal responses, respectively, the relationship between tumor size and vestibular function can be expressed as: tumor size (cm)=1.43 (caloric response)+1.35 (VEMP response), indicating that the estimated tumor size for those with abnormal caloric or VEMP responses increased by 1.43 or 1.35 cm, respectively.
  • [MeSH-major] Cochlea / physiopathology. Hearing Loss / physiopathology. Neuroma, Acoustic / physiopathology. Ocular Motility Disorders / physiopathology. Vestibule, Labyrinth / physiopathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Audiometry. Diagnosis, Differential. Electronystagmography. Evoked Potentials. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Nystagmus, Optokinetic. Prognosis. Severity of Illness Index. Vestibular Function Tests

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  • (PMID = 18568517.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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39. Forssén UM, Lönn S, Ahlbom A, Savitz DA, Feychting M: Occupational magnetic field exposure and the risk of acoustic neuroma. Am J Ind Med; 2006 Feb;49(2):112-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occupational magnetic field exposure and the risk of acoustic neuroma.
  • BACKGROUND: Acoustic neuroma is the intracranial tumor subtype showing the highest relative risk in relation to ionizing radiation but other environmental risk factors are largely unknown.
  • CONCLUSION: This study is the largest ever on acoustic neuroma and the first study to evaluate this tumor subtype specifically in relation to extremely low frequency magnetic fields.
  • The results do not support the hypothesis that 50 Hz magnetic fields increase the risk of acoustic neuroma.
  • [MeSH-major] Electromagnetic Fields / adverse effects. Neuroma, Acoustic / epidemiology. Occupational Exposure / adverse effects


40. Hours M, Bernard M, Arslan M, Montestrucq L, Richardson L, Deltour I, Cardis E: Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France. Occup Environ Med; 2009 Jul;66(7):480-6
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  • [Title] Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France.
  • OBJECTIVES: To investigate possible associations between risk of acoustic neuroma and exposure to loud noise in leisure and occupational settings.
  • The cases were the 108 subjects diagnosed with acoustic neuroma between 1 June 2000 and 31 August 2003.
  • RESULTS: Acoustic neuroma was found to be associated with loud noise exposure (odds ratio (OR) = 2.55; 95% CI 1.35 to 4.82), both in leisure settings, particularly when listening to loud music (OR = 3.88; 95% CI 1.48 to 10.17) and at work (OR = 2.26; 95% CI 1.08 to 4.72).
  • CONCLUSION: The present results agree with other recent reports implicating loud noise in the risk of acoustic neuroma.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology. Noise / adverse effects


41. Edwards CG, Schwartzbaum JA, Nise G, Forssén UM, Ahlbom A, Lönn S, Feychting M: Occupational noise exposure and risk of acoustic neuroma. Am J Epidemiol; 2007 Dec 1;166(11):1252-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Occupational noise exposure and risk of acoustic neuroma.
  • A small number of prior epidemiologic studies of occupational noise exposure based on self-report have suggested an association with acoustic neuroma.
  • The goal of the present study was to further examine the association between noise exposure and acoustic neuroma by using an objective measure of exposure in the form of a job exposure matrix.
  • A total of 793 acoustic neuroma cases aged 21-84 years were identified between 1987 and 1999 from the Swedish Cancer Registry.
  • Contrary to previous study results, the present findings did not demonstrate an increased acoustic neuroma risk related to occupational noise exposure even after allowing for a long latency period.
  • [MeSH-major] Neuroma, Acoustic / etiology. Noise, Occupational / adverse effects. Occupational Exposure / adverse effects


42. Parietti-Winkler C, Gauchard GC, Simon C, Perrin PP: Sensorimotor postural rearrangement after unilateral vestibular deafferentation in patients with acoustic neuroma. Neurosci Res; 2006 Jun;55(2):171-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sensorimotor postural rearrangement after unilateral vestibular deafferentation in patients with acoustic neuroma.
  • Unilateral vestibular lesion, as acoustic neuroma and its surgical removal, leads to impaired balance control.
  • After initial vertigo and postural instability corresponding to unilateral vestibular deafferentation, improvement in symptoms and global balance functions occurs by a process called vestibular compensation.
  • In this respect, this prospective study aimed to assess the differential contribution of sensory inputs to the regulation of posture during the recovery process after acoustic neuroma removal.
  • Twenty-seven patients with acoustic neuroma underwent vestibular and posturographic testings, shortly before and 8 days, 1 month and 3 months after surgical removal of the tumour.
  • Immediately after vestibular deafferentation, vestibular function was asymmetrical, postural performances were altered, especially in eyes closed conditions and in sensory challenged situations.
  • One month, and more particularly 3 months after surgery, restoration and even improvement of vestibular and balance performances occurred, associated with a lower number of falls, development of more appropriate sensorimotor strategies and better resolution of sensorial conflicts.
  • Postural perturbations are related to erroneous vestibular afferences, leading to incoherence in information about head position and interference with somatosensory and visual pathways.
  • [MeSH-major] Denervation. Neuroma, Acoustic / surgery. Postural Balance / physiology. Posture / physiology. Vestibule, Labyrinth / innervation
  • [MeSH-minor] Adult. Analysis of Variance. Female. Functional Laterality. Humans. Male. Middle Aged. Nonlinear Dynamics. Otologic Surgical Procedures / methods. Prospective Studies. Vestibular Function Tests

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  • (PMID = 16621077.001).
  • [ISSN] 0168-0102
  • [Journal-full-title] Neuroscience research
  • [ISO-abbreviation] Neurosci. Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Ireland
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43. Brooker JE, Fletcher JM, Dally MJ, Briggs RJ, Cousins VC, Smee RI, Malham GM, Kennedy RJ, Burney S: Quality of life among acoustic neuroma patients managed by microsurgery, radiation, or observation. Otol Neurotol; 2010 Aug;31(6):977-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality of life among acoustic neuroma patients managed by microsurgery, radiation, or observation.
  • OBJECTIVE: The main aim of this study was to examine differences in quality of life (QoL) among acoustic neuroma patients across the management options of microsurgery, radiation, and observation.
  • PATIENTS: Participants included 180 adults diagnosed with, or treated for, a unilateral acoustic neuroma within 5 years of questionnaire distribution.
  • INTERVENTION(S): Patients' acoustic neuromas were managed with microsurgery, radiation, or observation.
  • CONCLUSION: This is only the second study to use multivariate statistical techniques and a large sample to examine QoL across the acoustic neuroma management options of microsurgery, radiation, and observation.
  • [MeSH-major] Cranial Nerve Neoplasms / psychology. Neuroma, Acoustic / psychology. Otologic Surgical Procedures. Quality of Life
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Glasgow Outcome Scale. Humans. Logistic Models. Male. Microsurgery. Middle Aged. Surveys and Questionnaires. Treatment Outcome. Young Adult


44. Bartoszewicz R, Niemczyk K, Marchel A, Kowalska M: [Sudden deafness as a presentation of acoustic neuroma]. Pol Merkur Lekarski; 2005 Sep;19(111):307-8
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  • [Title] [Sudden deafness as a presentation of acoustic neuroma].
  • [Transliterated title] Nagła głuchota w symptomatologii guzów nerwu VIII.
  • Acoustic neuroma should always be considered in the differential diagnosis.
  • The authors analysed symptoms occurring in the group of 89 patients, diagnosed with acoustic neuroma.
  • A special attention was paid to the role of sudden deafness as a clinical manifestation of the VIIIth nerve pathology.
  • [MeSH-major] Deafness / etiology. Headache / etiology. Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Tinnitus / etiology


45. Jalloh I, Guilfoyle MR, Lloyd SK, Macfarlane R, Smith C: Reactivation and centripetal spread of herpes simplex virus complicating acoustic neuroma resection. Surg Neurol; 2009 Nov;72(5):502-4
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  • [Title] Reactivation and centripetal spread of herpes simplex virus complicating acoustic neuroma resection.
  • CASE DESCRIPTION: A 44-year-old man underwent uneventful resection of an acoustic neuroma.
  • [MeSH-major] Encephalitis, Herpes Simplex / etiology. Facial Nerve Diseases / complications. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Neurosurgical Procedures / adverse effects. Simplexvirus / genetics
  • [MeSH-minor] Acyclovir / therapeutic use. Adult. Antiviral Agents / therapeutic use. Consciousness Disorders / virology. DNA, Viral / analysis. Facial Nerve / surgery. Facial Nerve / virology. Fever / virology. Humans. Magnetic Resonance Imaging. Male. Recurrence. Tomography, X-Ray Computed. Vestibulocochlear Nerve / pathology. Vestibulocochlear Nerve / radiography. Vestibulocochlear Nerve / surgery. Vomiting / virology

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  • (PMID = 19631366.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiviral Agents; 0 / DNA, Viral; X4HES1O11F / Acyclovir
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46. Wackym PA: Stereotactic radiosurgery, microsurgery, and expectant management of acoustic neuroma: basis for informed consent. Otolaryngol Clin North Am; 2005 Aug;38(4):653-70
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  • [Title] Stereotactic radiosurgery, microsurgery, and expectant management of acoustic neuroma: basis for informed consent.
  • Stereotactic radio-surgery, like any other treatment modality, has advantages and disadvantages that must be discussed with a patient who has an acoustic neuroma or other skull base tumor.
  • [MeSH-major] Neuroma, Acoustic / surgery. Otorhinolaryngologic Surgical Procedures. Radiosurgery

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  • (PMID = 16005724.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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47. Tufarelli D, Meli A, Alesii A, De Angelis E, Badaracco C, Falcioni M, Sanna M: Quality of life after acoustic neuroma surgery. Otol Neurotol; 2006 Apr;27(3):403-9
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  • [Title] Quality of life after acoustic neuroma surgery.
  • OBJECTIVE: The aim of this study is to assess patients' quality of life after acoustic neuroma surgery, and if some patients' characteristics, parameters of tumor and surgical parameters affect patients' quality of life.
  • PATIENTS: A group of 386 patients who underwent acoustic neuroma surgery.
  • INTERVENTION: Patients included were derived from a population of 459 subjects operated for acoustic neuroma by the Otologic Group of Piacenza.
  • Our data indicate that an early surgical approach for intrameatal tumor is better than waiting for an increase in the tumor size.
  • A "wait-and-scan" strategy for extrameatal neuromas which do not affect the brainstem is preferable, since these patients have a worsening of their quality of life after surgery independently of the tumor size.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life

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  • (PMID = 16639281.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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48. Saito AI, Morris CG, Ito K, Watanabe F, Karasawa K, Mendenhall WM, Naoi Y: Comparing size evaluation methods for acoustic neuroma after stereotactic radiosurgery. Radiat Med; 2007 Aug 1;25(7):339-45
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparing size evaluation methods for acoustic neuroma after stereotactic radiosurgery.
  • PURPOSE: Acoustic neuroma tumor size may be evaluated using several methods.
  • MATERIALS AND METHODS: A retrospective analysis of pre- and posttreatment magnetic resonance (MR) scans was performed on 15 acoustic neuroma patients with a history of stereotactic radiosurgery who had been followed for more than 2 years.
  • Tumor size was measured on each MR scan using three methods, where the extracanalicular (EX) and intracanalicular (IN) portions were measured separately.
  • Size differences between follow-up MR scans separated by more than 2 years were calculated for each method, and we evaluated whether the tumors progressed, remained stable, or regressed.
  • CONCLUSION: A significant difference between the tumor size measuring methods was observed.
  • To strengthen specificity when evaluating tumor size difference, a measuring method using two or more parameters is recommended.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Artifacts. Disease Progression. Female. Humans. Male. Middle Aged. Reproducibility of Results. Retrospective Studies. Stereotaxic Techniques. Treatment Outcome

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  • (PMID = 17705004.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Japan
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49. Yu LM, Yang SM, Han DY, Yu LM, Yang WY: [Preliminary study of intraoperative auditory monitoring techniques in acoustic neuroma surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 May;41(5):335-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Preliminary study of intraoperative auditory monitoring techniques in acoustic neuroma surgery].
  • OBJECTIVE: To investigate the value of intraoperative auditory monitoring techniques in acoustic neuroma surgery.
  • METHODS: Ten cases with acoustic neuroma were resected with retrosigmoid approach.
  • The hearing was preserved in 2 cases, which had class A hearing post operation with tumor size <2 cm.
  • In another case, the waves of I, III could be evoked after the tumor resection with the disappearance of wave V.
  • The 6 out of 8 cases showed up CAP (waves I ) waveform.
  • The CAP amplitudes decreased significantly in 4 cases and even dropped to zero while dissecting the tumor at the lateral end of the internal auditory canal (IAC) or clamping the internal auditory artery (IAA) during operation.
  • In one case, although the cochlear nerve was cut down, the CAP could still be recorded after the tumor resection.
  • However, the CAP amplitudes was dropped to zero while pressurized and pulled cochlea nerve of brainstem lateral and the wave disappeared post-operation in another cases.
  • One of them showed low amplitude of CAP wave when the tumor partially removed.
  • CONCLUSIONS: In combination with ABR monitoring, ECochG proved to be a useful supplementary tool for hearing preservation in acoustic neurinoma surgery.
  • Drilling of the IAC and tumor removal at the lateral end of the IAC were the most critical steps for achieving hearing preservation.
  • The surgeon's experience are the most significant factors influencing the hearing outcome after removal of acoustic neuroma.
  • [MeSH-major] Cochlear Nerve / physiopathology. Monitoring, Intraoperative / methods. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Adolescent. Adult. Audiometry, Evoked Response. Evoked Potentials, Auditory, Brain Stem. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 16848284.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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50. Jaspers GW, Stegenga B: [Trigeminal neuralgia by an acoustic neuroma. The need of imaging]. Ned Tijdschr Tandheelkd; 2005 Jun;112(6):231-3
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  • [Title] [Trigeminal neuralgia by an acoustic neuroma. The need of imaging].
  • [Transliterated title] Trigeminusneuralgie door een neurinoom van de nervus acusticus. De noodzaak van beeldvormend onderzoek.
  • In a 43-year old female with neuralgia of the second and third branch of the trigeminal nerve, the diagnosis was made on the basis of clinical findings.
  • This investigation showed an acoustic neuroma in the cerebellopontine angle.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Trigeminal Neuralgia / diagnosis. Trigeminal Neuralgia / etiology


51. Browne S, Distel E, Morton RP, Petrie KJ: Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):417-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma.
  • OBJECTIVES: We compared the quality of life of patients with acoustic neuroma (AN) with general population controls and other chronic illness patients.
  • METHODS: A research questionnaire was sent to all 119 members of the Acoustic Neuroma Association of New Zealand.
  • However, most AN patients do report finding some benefit from their illness experience.
  • [MeSH-major] Hearing / physiology. Neuroma, Acoustic / psychology. Otologic Surgical Procedures / methods. Quality of Life

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  • (PMID = 19128648.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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52. Verma S, Anthony R, Tsai V, Taplin M, Rutka J: Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma. Clin Otolaryngol; 2009 Oct;34(5):438-46
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of cost effectiveness for conservative and active management strategies for acoustic neuroma.
  • OBJECTIVE: To determine whether economic costs associated with a conservative management strategy for unilateral acoustic neuroma offer an economic advantage over active management options.
  • PARTICIPANTS: 72 patients (32 males, 40 females) aged 36 to 78 years with unilateral acoustic neuroma were assigned initially to a conservative management strategy.
  • CONCLUSION: An economic advantage can be demonstrated for the conservative management of acoustic neuromas compared to microsurgical removal and gamma knife radiotherapy on the proviso that no increase in active treatment complications arose from continued tumour growth during the period of observation.
  • [MeSH-major] Neuroma, Acoustic / economics. Neuroma, Acoustic / therapy

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  • [CommentIn] Clin Otolaryngol. 2010 Feb;35(1):69-70; author reply 70-1 [20447172.001]
  • (PMID = 19793276.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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53. Yingling CD, Gardi JN: Intraoperative monitoring of facial and cochlear nerves during acoustic neuroma surgery. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):289-315, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative monitoring of facial and cochlear nerves during acoustic neuroma surgery. 1992.
  • Preservation of facial nerve function during acoustic neuroma surgery can be improved significantly by monitoring of facial electromyography (EMG) during surgery.
  • Electrical stimulation can be used to locate the nerve even when it is out of direct view, and the threshold for stimulation provides a measure of facial (or other motor nerve) integrity.
  • Cochlear nerve function also can be monitored by the recording of auditory brain stem responses or compound action potentials from an electrode placed on the nerve at the brain stem root entry zone.
  • [MeSH-major] Monitoring, Intraoperative / history. Neuroma, Acoustic / history. Neurosurgical Procedures / history
  • [MeSH-minor] Cochlear Nerve. Facial Nerve. History, 20th Century. Humans

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  • (PMID = 18534341.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Yingling CD; Gardi JN
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54. Arriaga MA, Chen DA, Burke EL: Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. Otol Neurotol; 2007 Jun;28(4):538-40
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  • [Title] Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update.
  • OBJECTIVE: To update the outcome of hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma (TLAN) surgery.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, Inner / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures

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  • (PMID = 17414174.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 91D9GV0Z28 / Durapatite
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55. Cohen HS, Bloomberg JJ: Modified dynamic visual acuity tests after acoustic neuroma resection. Acta Otolaryngol; 2007 Aug;127(8):825-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modified dynamic visual acuity tests after acoustic neuroma resection.
  • MATERIALS AND METHODS: Normal subjects and patients scheduled for acoustic neuroma resection were tested preoperatively.
  • [MeSH-major] Neuroma, Acoustic / physiopathology. Otologic Surgical Procedures / methods. Vision Tests / methods. Visual Acuity

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  • (PMID = 17762992.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Norway
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56. Coca A, Gómez JR, Llorente JL, Rodrigo JP, Núñez F, Sevilla MA, Suárez C: [Complications and sequelae in acoustic neuroma surgery]. Acta Otorrinolaringol Esp; 2007 Dec;58(10):470-5
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  • [Title] [Complications and sequelae in acoustic neuroma surgery].
  • [Transliterated title] Complicaciones y secuelas en la cirugía de los neurinomas del acústico.
  • OBJECTIVE: To evaluate the complications and sequelae of acoustic neuroma surgery, according to tumour size.
  • PATIENTS AND METHOD: A retrospective analysis of 120 patients who underwent microsurgical resection of vestibular schwannomas between November 1994 and September 2006 was undertaken.
  • The facial nerve was anatomically and functionally preserved in 103 cases on long-term follow-up (85.4 %).
  • The cochlear nerve was functionally preserved (Gardner-Robertson class 1 and 2) in 54.4 % of the small tumours with useful preoperative hearing.
  • CONCLUSIONS: Despite the progress in the surgical treatment of acoustic neuromas, a considerable rate of complications and sequelae still remains.
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / statistics & numerical data. Postoperative Complications / epidemiology

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  • (PMID = 18082077.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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57. Newton JR, Shakeel M, Flatman S, Beattie C, Ram B: Magnetic resonance imaging screening in acoustic neuroma. Am J Otolaryngol; 2010 Jul-Aug;31(4):217-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Magnetic resonance imaging screening in acoustic neuroma.
  • OBJECTIVES: Magnetic resonance imaging (MRI) is the definitive investigation for detection of an acoustic neuroma.
  • It is however an expensive resource, and pick-up rate of a tumor can be as low as 1% of all patients scanned.
  • In addition, MRI scans and case records were reviewed for the last 30 patients diagnosed with acoustic neuromas.
  • RESULTS: Two acoustic neuromas were picked up out of 132 scans performed.
  • Of the 30 positive scans for a tumor, the patients/audiograms revealed that 10% did not fit the published criteria despite the patients having no other audiovestibular symptoms.
  • Applying protocols may reduce the amount of scans performed, but up to 10% of tumors may be missed by this approach.
  • [MeSH-major] Hearing Loss, Sensorineural / diagnosis. Magnetic Resonance Imaging / methods. Neuroma, Acoustic / diagnosis

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20015748.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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58. Yu LM, Yang SM, Han DY, Huang DL, Yang WY: [Management of operative complications in acoustic neuroma surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jan;41(1):26-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of operative complications in acoustic neuroma surgery].
  • OBJECTIVE: To explore the common complications related to acoustic neuromas and to search methods for preventing from them.
  • METHODS: One hundred and five patients with acoustic neuromas underwent 110 operations with the retrosigmoid approach, middle cranial fossa approach and labyrinth approach.
  • Other complications were cerebrospinal fluid fistulas (CSF, 12.7%, 14/110) , intracranial hematoma (5.5%, 6/110), cranial nerve palsies (4.5%, 5/110), meningitis (3.6%, 4/110), tetraparesis (3.6%, 4/110), balance disturbance (1.8%, 2/110), hemiparalysis and anepia (0.9%, 1/110).
  • Effective stopping bleeding during operation and controlling blood pressure after operation, as well as keeping effective sedation in 24 hours after operation were the important ways to prevent from intracranial hematoma The haemorrhage often accrued in 48 hours post-operation.
  • CSF in this series was another common complication in acoustic neuroma surgery.
  • CONCLUSIONS: The key factors to avoid the complications include mastering the anatomy of different surgical approach, how much of the tumor size, surgical experience and preoperative evaluation of patients' imaging information and other clinical data.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control

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  • (PMID = 16646239.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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59. Ishiyama G, Lopez IA, Beltran-Parrazal L, Ishiyama A: Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. Cell Tissue Res; 2010 Jun;340(3):407-19
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  • [Title] Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma.
  • Meniere's disease is nearly invariably associated with endolymphatic hydrops (the net accumulation of water in the inner ear endolymphatic space).
  • Vestibular maculae utriculi were acquired from patients undergoing surgery for Meniere's disease and acoustic neuroma and from autopsy (subjects with normal hearing and balance).
  • Quantitative immunostaining was conducted with antibodies against aquaporins (AQPs) 1, 4, and 6, Na(+)K(+)ATPase, Na(+)K(+)2Cl co-transporter (NKCC1), and alpha-syntrophin. mRNA was extracted from the surgically acquired utricles from subjects with Meniere's disease and acoustic neuroma to conduct quantitative real-time reverse transcription with polymerase chain reaction for AQP1, AQP4, and AQP6.
  • AQP1 immunoreactivity (-IR) was located in blood vessels and fibrocytes in the underlying stroma, without any apparent alteration in Meniere's specimens when compared with acoustic neuroma and autopsy specimens.
  • AQP4-IR localized to the epithelial basolateral supporting cells in Meniere's disease, acoustic neuroma, and autopsy.
  • In specimens from subjects with Meniere's disease, AQP4-IR was significantly decreased compared with autopsy and acoustic neuroma specimens.
  • AQP6-IR occurred in the sub-apical vestibular supporting cells in acoustic neuroma and autopsy samples.
  • However, in Meniere's disease specimens, AQP6-IR was significantly increased and diffusely redistributed throughout the supporting cell cytoplasm.
  • Na(+)K(+)ATPase, NKCC1, and alpha-syntrophin were expressed within sensory epithelia and were unaltered in Meniere's disease specimens.
  • Expression of AQP1, AQP4, or AQP6 mRNA did not differ in vestibular endorgans from patients with Meniere's disease.
  • Changes in AQP4 (decreased) and AQP6 (increased) expression in Meniere's disease specimens suggest that the supporting cell might be a cellular target.

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  • (PMID = 20461409.001).
  • [ISSN] 1432-0878
  • [Journal-full-title] Cell and tissue research
  • [ISO-abbreviation] Cell Tissue Res.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / 5U24 DC008635; United States / NIDCD NIH HHS / DC / DC005028; United States / NIDCD NIH HHS / DC / DC005187; United States / NIDCD NIH HHS / DC / U24 DC008635; United States / NIDCD NIH HHS / DC / R01 DC005028; United States / NIDCD NIH HHS / DC / K08 DC005187
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Aquaporins; 0 / Ions; 0 / Protein Isoforms; 0 / RNA, Messenger
  • [Other-IDs] NLM/ PMC2882038
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60. Takao T, Fukuda M, Kawaguchi T, Nishino K, Ito Y, Tanaka R, Sato M: Ruptured intracranial aneurysm following gamma knife surgery for acoustic neuroma. Acta Neurochir (Wien); 2006 Dec;148(12):1317-8; discussion 1318
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  • [Title] Ruptured intracranial aneurysm following gamma knife surgery for acoustic neuroma.
  • A-63-year-old woman underwent gamma knife surgery (GKS) for acoustic neuroma.
  • This is the first report of aneurysm formation following GKS for acoustic neuroma.
  • [MeSH-major] Basilar Artery / radiation effects. Intracranial Aneurysm / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / etiology. Radiosurgery / adverse effects
  • [MeSH-minor] Cerebral Angiography. Embolization, Therapeutic. Female. Headache / etiology. Humans. Iatrogenic Disease / prevention & control. Middle Aged. Preoperative Care / standards. Radiation Dosage. Subarachnoid Hemorrhage / etiology. Subarachnoid Hemorrhage / pathology. Subarachnoid Hemorrhage / physiopathology. Tomography, X-Ray Computed. Treatment Outcome


61. Durko M, Jankowski A, Durko T, Gajewicz W, Pajor A: [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness]. Otolaryngol Pol; 2008;62(2):204-8
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  • [Title] [Coexistence of acoustic neuroma and pineal region tumor in patient with sudden deafness].
  • INTRODUCTION: Acoustic neuroma usually presents as an unilateral tumor, seldom - bilateral and rarely in coexistence with other central nervous system neoplasms.
  • Audiometry revealed moderate sensorineural hearing loss in left ear (for low and middle frequencies), brainstem auditory evoked potentials were absent on the left side and ENG examination showed left peripheral vestibular impairment.
  • MRI study revealed in the left internal acoustic meatus mass (7 x 7 x 14 mm) suggesting acoustic neuroma and an oval mass (7 x 9 x 14 mm) in the pineal gland presenting radiological features of pinealoma.
  • Acoustic neuroma has been removed by suboccipital approach and pinealoma has been left for further observation as it was found incidentally.
  • Histopathological examination confirmed diagnosis of left VIII nerve schwannoma.
  • The postoperative course shows no evidence of acoustic neuroma recurrence.
  • [MeSH-major] Deafness / etiology. Neoplasms, Second Primary / diagnosis. Neuroma, Acoustic / diagnosis. Pinealoma / diagnosis


62. Suzuki M, Hashimoto S, Kano S, Okitsu T: Prevalence of acoustic neuroma associated with each configuration of pure tone audiogram in patients with asymmetric sensorineural hearing loss. Ann Otol Rhinol Laryngol; 2010 Sep;119(9):615-8
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  • [Title] Prevalence of acoustic neuroma associated with each configuration of pure tone audiogram in patients with asymmetric sensorineural hearing loss.
  • The purpose of this study was to determine the prevalence of acoustic neuroma associated with each configuration of the pure tone audiogram in patients with asymmetric sensorineural hearing loss (SNHL).
  • RESULTS: The prevalence of acoustic neuroma in these patients was 2.6% (13 of 500).
  • The prevalence of acoustic neuroma in each audiometric configuration was as follows: 7.1% (3 of 42) for a basin-shaped loss (odds ratio [OR] versus overall prevalence, 2.88; p = 0.23; 95% confidence interval [CI], 0.79 to 10.54), 4.7% (5 of 107) for a flat loss, 3.4% (2 of 58) for total deafness, 2.9% (1 of 34) for a high-frequency sloping audiogram, and 2.5% (2 of 81) for a high-frequency steep audiogram.
  • CONCLUSIONS: In conclusion, 2.9% to 8.1% of patients with a characteristic configuration of the pure tone audiogram and symptoms of nonimproving or progressive idiopathic sudden deafness may have acoustic neuroma.
  • [MeSH-major] Audiometry, Pure-Tone / statistics & numerical data. Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / epidemiology. Hearing Loss, Unilateral / diagnosis. Hearing Loss, Unilateral / epidemiology. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / epidemiology


63. Treleaven J, LowChoy N, Darnell R, Panizza B, Brown-Rothwell D, Jull G: Comparison of sensorimotor disturbance between subjects with persistent whiplash-associated disorder and subjects with vestibular pathology associated with acoustic neuroma. Arch Phys Med Rehabil; 2008 Mar;89(3):522-30
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  • [Title] Comparison of sensorimotor disturbance between subjects with persistent whiplash-associated disorder and subjects with vestibular pathology associated with acoustic neuroma.
  • OBJECTIVE: To determine if differences exist in reported symptoms and in outcomes of sensorimotor tests (cervical joint position error [JPE], neck-influenced eye movement control, postural stability) between subjects with persistent whiplash and subjects with unilateral vestibular pathology associated with acoustic neuroma.
  • PARTICIPANTS: Twenty subjects with persistent whiplash, 20 subjects with acoustic neuroma, and 20 control subjects.
  • RESULTS: The results showed differences in SPNT (P=.00), selected measures of postural stability (P<.04), and reported symptoms between the whiplash and vestibular groups.
  • CONCLUSIONS: This study showed differences in sensorimotor disturbances between subjects with discreet whiplash and those with vestibular pathology associated with acoustic neuroma.
  • [MeSH-major] Gait Disorders, Neurologic / diagnosis. Neuroma, Acoustic / diagnosis. Sensation Disorders / diagnosis. Sensation Disorders / etiology. Whiplash Injuries / diagnosis
  • [MeSH-minor] Adult. Case-Control Studies. Eye Movements / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Postural Balance / physiology. Probability. Proprioception / physiology. Risk Assessment. Surveys and Questionnaires. Vestibular Function Tests


64. Goodwin L: Acoustic neuroma and radiosurgery. J Insur Med; 2007;39(1):44-6
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  • [Title] Acoustic neuroma and radiosurgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 17500357.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Han DY, Yu LM, Yu LM, Ji F, Young WY, Yang SM: Acoustic neuroma surgery for preservation of hearing: technique and experience in the Chinese PLA General Hospital. Acta Otolaryngol; 2010 May;130(5):583-92
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  • [Title] Acoustic neuroma surgery for preservation of hearing: technique and experience in the Chinese PLA General Hospital.
  • CONCLUSIONS: Good hearing preservation can be achieved during acoustic neuroma surgery assisted by real-time dynamic auditory monitoring and ear endoscopic techniques.
  • OBJECTIVE: To explore techniques to preserve hearing during acoustic neuroma resection.
  • From July 2003 to July 2007, intraoperative auditory monitoring using auditory brainstem response (ABR) and electrocochleography (EcochG) was conducted in 18 of 138 patients undergoing surgery for acoustic neuroma who had preoperative hearing.
  • RESULTS: Hearing was preserved in 11 of the 18 patients (61.1%): 2 of 5 patients whose tumors were larger than 20 mm (40%), and 9 of 13 patients with smaller tumors (69.2%).
  • Intraoperative monitoring revealed that the waveform was influenced when the posterior labium of the internal acoustic meatus was ground and drilled, or when traction or electrocoagulation was performed near the opening of the internal acoustic meatus, especially when the internal auditory artery was clamped, the tumor in the internal acoustic meatus was treated, and the arachnoid vessels in the inner-most layer of the tumor surface were clamped or electrocoagulated.
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects
  • [MeSH-minor] Adolescent. Adult. Facial Nerve Diseases / etiology. Female. Hearing Tests. Humans. Male. Middle Aged. Retrospective Studies. Young Adult

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  • (PMID = 20406132.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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66. Schlehofer B, Schlaefer K, Blettner M, Berg G, Böhler E, Hettinger I, Kunna-Grass K, Wahrendorf J, Schüz J, Interphone Study Group: Environmental risk factors for sporadic acoustic neuroma (Interphone Study Group, Germany). Eur J Cancer; 2007 Jul;43(11):1741-7
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  • [Title] Environmental risk factors for sporadic acoustic neuroma (Interphone Study Group, Germany).
  • The only known risk factor for sporadic acoustic neuroma is high-dose ionising radiation.
  • We performed a population-based case-control study in Germany investigating these risk factors in 97 cases with acoustic neuroma, aged 30 to 69 years, and in 194 matched controls.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / epidemiology
  • [MeSH-minor] Adult. Aged. Case-Control Studies. Cell Phones / statistics & numerical data. Electromagnetic Fields / adverse effects. Female. Germany / epidemiology. Hearing Disorders / epidemiology. Humans. Male. Middle Aged. Noise, Occupational / adverse effects. Noise, Occupational / statistics & numerical data. Radiation, Ionizing. Risk Factors

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  • (PMID = 17600696.001).
  • [ISSN] 0959-8049
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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67. Hardell L, Carlberg M, Hansson Mild K: Case-control study on cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000-2003. Neuroepidemiology; 2005;25(3):120-8
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  • [Title] Case-control study on cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000-2003.
  • We performed a case-control study on the use of cellular and cordless telephones and the risk for brain tumors.
  • We report the results for benign brain tumors with data from 413 cases (89% response rate), 305 with meningioma, 84 with acoustic neuroma, 24 with other types and 692 controls (84% response rate).
  • For acoustic neuroma, analogue phones gave OR = 4.2, 95% CI = 1.8-10 increasing to OR = 8.4, 95% CI = 1.6-45 with a >15-year latency period, but based on low numbers.
  • In the multivariate analysis, analogue phones represented a significant risk factor for acoustic neuroma.
  • [MeSH-major] Cell Phones / utilization. Meningeal Neoplasms / etiology. Meningioma / etiology. Neuroma, Acoustic / etiology

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15956809.001).
  • [ISSN] 0251-5350
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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68. Baumann I, Polligkeit J, Blumenstock G, Mauz PS, Zalaman IM, Maassen MM: Quality of life after unilateral acoustic neuroma surgery via middle cranial fossa approach. Acta Otolaryngol; 2005 Jun;125(6):585-91
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  • [Title] Quality of life after unilateral acoustic neuroma surgery via middle cranial fossa approach.
  • CONCLUSIONS: Patients with acoustic neuroma experienced reduced quality of life (QOL) after surgery.
  • In the future, QOL should be a basic factor in the outcome evaluation of different therapeutic regimens in the treatment of acoustic neuroma.
  • OBJECTIVE: To measure the QOL of patients who underwent unilateral acoustic neuroma surgery via the middle cranial fossa approach.
  • MATERIAL AND METHODS: The Short Form-36 (SF-36) Health Survey and a self-designed disease-specific questionnaire were used during follow-up examinations to assess health-related QOL.
  • Facial nerve function was described using the House-Brackmann grading system.
  • Gender, age, tumor size or location and clinical symptoms such as hearing loss and restricted facial nerve function did not have an effect on QOL.
  • [MeSH-major] Cranial Fossa, Middle / surgery. Neuroma, Acoustic / surgery. Quality of Life
  • [MeSH-minor] Adult. Age Factors. Aged. Attitude to Health. Audiometry, Pure-Tone. Auditory Threshold / physiology. Bone Conduction / physiology. Facial Nerve / physiopathology. Facial Paralysis / physiopathology. Female. Follow-Up Studies. Hearing Disorders / physiopathology. Humans. Male. Middle Aged. Sex Factors

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  • (PMID = 16076706.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Norway
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69. Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD: DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol; 2010 Jan;12(1):37-48
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  • [Title] DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
  • Although the etiology of primary brain tumors is largely unknown, prior studies suggest that DNA repair polymorphisms may influence risk of glioma.
  • Altered DNA repair is also likely to affect the risk of meningioma and acoustic neuroma, but these tumors have not been well studied.
  • We estimated the risk of glioma (n = 362), meningioma (n = 134), and acoustic neuroma (n = 69) in non-Hispanic whites with respect to 36 single nucleotide polymorphisms from 26 genes involved in DNA repair in a hospital-based, case-control study conducted by the National Cancer Institute.
  • Risk of acoustic neuroma was increased for the ERCC2 rs1799793 (P(trend) .03) and ERCC5 rs17655 (P(trend) .05) variants and decreased for the PARP1 rs1136410 (P(trend) .03).
  • Our results suggest that common DNA repair variants may affect the risk of adult brain tumors, especially meningioma.


70. Nichetti E, Pelosi A, Piccirillo E, Sanna M, Bettinardi O, Rovetto F: [Emotional aspects and quality of life of patients after acoustic neuroma surgery]. G Ital Med Lav Ergon; 2009 Jan-Mar;31(1 Suppl A):A52-7
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  • [Title] [Emotional aspects and quality of life of patients after acoustic neuroma surgery].
  • [Transliterated title] Aspetti emotivi e qualità della vita in pazienti operati di neurinoma del nervo acustico.
  • Acoustic neuromas are rare lesions arising in the internal auditory canal (IAC) and extending in the posterior cranial fossa.
  • METHODS: By using a questionnaires of Quality of Life aims to evaluate the impact that the disease and the surgical procedure have on this population.
  • SUBJECTS: We have evaluated a sample of 150 subjects one year after the surgical removal of a acoustic neuroma.
  • CONCLUSION: Psychological support to subjects after discharge from acoustic neuroma surgical removal should be tailored to improve quality of life and for a better management of anxiety.
  • [MeSH-major] Anxiety / etiology. Neuroma, Acoustic / psychology. Quality of Life / psychology

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  • (PMID = 19621539.001).
  • [ISSN] 1592-7830
  • [Journal-full-title] Giornale italiano di medicina del lavoro ed ergonomia
  • [ISO-abbreviation] G Ital Med Lav Ergon
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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71. Ryzenman JM, Pensak ML, Tew JM Jr: Headache: a quality of life analysis in a cohort of 1,657 patients undergoing acoustic neuroma surgery, results from the acoustic neuroma association. Laryngoscope; 2005 Apr;115(4):703-11
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  • [Title] Headache: a quality of life analysis in a cohort of 1,657 patients undergoing acoustic neuroma surgery, results from the acoustic neuroma association.
  • OBJECTIVES: On the basis of survey results of the Acoustic Neuroma Association (ANA), we report patient ratings of postoperative headache (POH) symptoms, determine its effect on quality of life (QOL), and review the literature regarding POH after acoustic neuroma (AN) treatment.
  • Responses were analyzed by tumor size, surgical approach, and patient age and sex.
  • [MeSH-major] Headache / psychology. Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life

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  • (PMID = 15805885.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Analgesics, Opioid; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Nonprescription Drugs
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72. Göksu N, Yilmaz M, Bayramoglu I, Aydil U, Bayazit YA: Evaluation of the results of endoscope-assisted acoustic neuroma surgery through posterior fossa approach. ORL J Otorhinolaryngol Relat Spec; 2005;67(2):87-91
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  • [Title] Evaluation of the results of endoscope-assisted acoustic neuroma surgery through posterior fossa approach.
  • The objective of this study was to evaluate the results of endoscope-assisted acoustic neuroma surgery in posterior fossa approach.
  • Between 1996 and 2002, 60 consecutive patients with acoustic neuroma were operated via the retrosigmoid suboccipital approach.
  • Standard 4-mm sinus endoscopes at different angles were used during the surgeries either for inspection or tumor endoscopic dissection.
  • Tumor sizes were small, medium and large in 46.6, 45 and 8.3% of the patients, respectively.
  • The hearing preservation rate, which did not correlate with tumor size (p > 0.05), was 24.4%.
  • The need for facial reanimation surgery, which was needed in 5% of patients, was significantly higher in the large tumors than in the small and medium tumors (p < 0.001).
  • Cerebrospinal fluid fistula rate, which was not related to tumor size (p > 0.05), was 13.3%.
  • Tumor recurrence or residual tumor was not encountered at all.
  • In conclusion, endoscopes give accurate information about the relationship between the tumor and the adjacent structures and help control the fundus of the internal auditory canal to ensure complete tumor removal.
  • The use of endoscopes does not appear to increase the hearing preservation rate, but is very helpful in complete tumor removal in the posterior fossa approach.
  • [MeSH-major] Cranial Fossa, Posterior / surgery. Endoscopy / methods. Neuroma, Acoustic / surgery

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  • [Copyright] Copyright 2005 S. Karger AG, Basel.
  • (PMID = 15795520.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Switzerland
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73. Chen DA: Acoustic neuroma in a private neurotology practice: trends in demographics and practice patterns. Laryngoscope; 2007 Nov;117(11):2003-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acoustic neuroma in a private neurotology practice: trends in demographics and practice patterns.
  • OBJECTIVES/HYPOTHESIS: To determine whether changes in demographics and management of patients with acoustic neuromas occurred between the years 1990 and 2005.
  • METHODS: Charts of all 614 patients with a diagnosis of acoustic neuroma, excluding neurofibromatosis-2, from 1990 through 2005 were reviewed.
  • Age at diagnosis, tumor size, hearing, and initial therapy (observation, stereotactic radiation, or surgical excision) were obtained.
  • Average tumor size decreased from 1.7 cm initially to 1.4 cm most recently (P < or = .039).
  • These changes in initial treatment choices occurred for all age groups and primarily for small tumors.
  • CONCLUSION: : Patients with acoustic neuroma are presenting with increased age and smaller tumors compared with 16 years ago.
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / therapy. Practice Patterns, Physicians' / statistics & numerical data

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  • (PMID = 17828042.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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74. Vereeck L, Wuyts FL, Truijen S, De Valck C, Van de Heyning PH: The effect of early customized vestibular rehabilitation on balance after acoustic neuroma resection. Clin Rehabil; 2008 Aug;22(8):698-713
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The effect of early customized vestibular rehabilitation on balance after acoustic neuroma resection.
  • OBJECTIVE: To compare the effect of early customized vestibular rehabilitation with general instructions in patients after acoustic neuroma surgery.
  • INTERVENTIONS: After stratification for age (<50 years; >or=50 years), patients were randomly allocated into groups receiving general instructions or customized vestibular rehabilitation protocols for 12 weeks.
  • However, older subjects receiving vestibular rehabilitation performed significantly (P<0.05) better on standing balance, Timed Up and Go test and Tandem Gait, when compared with the older group that received only general instructions.
  • In addition, the older vestibular rehabilitation group had better balance scores at 12 weeks when compared with their original preoperative scores (P<0.05).
  • CONCLUSION: In patients over 50, early vestibular rehabilitation facilitates recovery of postural control after acoustic neuroma surgery.
  • Customized vestibular rehabilitation should be given in addition to general instructions that stress the need of exposure to movement.
  • Retention of the early beneficial effects even one year after surgery stresses the importance of customized vestibular rehabilitation.
  • [MeSH-major] Dizziness / rehabilitation. Exercise Therapy / methods. Neuroma, Acoustic / secondary. Postural Balance


75. Hartsell T, Long D, Kirsch JR: The efficacy of postoperative ondansetron (Zofran) orally disintegrating tablets for preventing nausea and vomiting after acoustic neuroma surgery. Anesth Analg; 2005 Nov;101(5):1492-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The efficacy of postoperative ondansetron (Zofran) orally disintegrating tablets for preventing nausea and vomiting after acoustic neuroma surgery.
  • We evaluated the ability of intraoperative IV ondansetron followed by postoperative ondansetron in an orally disintegrating tablet formulation to reduce the frequency and severity of postoperative nausea and vomiting in a prospective, randomized, placebo-controlled double-blind trial of 60 patients undergoing acoustic neuroma resection.
  • We conclude that after acoustic neuroma surgery IV ondansetron treatment prevents immediate postoperative nausea and vomiting.
  • [MeSH-major] Antiemetics / administration & dosage. Neuroma, Acoustic / surgery. Ondansetron / administration & dosage. Postoperative Nausea and Vomiting / prevention & control

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  • (PMID = 16244017.001).
  • [ISSN] 0003-2999
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiemetics; 0 / Tablets; 4AF302ESOS / Ondansetron
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76. Balasubramaniam A, Shannon P, Hodaie M, Laperriere N, Michaels H, Guha A: Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literature. Neuro Oncol; 2007 Oct;9(4):447-53
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  • [Title] Glioblastoma multiforme after stereotactic radiotherapy for acoustic neuroma: case report and review of the literature.
  • Indications for the use of radiotherapy in the management of a variety of benign intracranial neoplastic and nonneoplastic pathologies are increasing.
  • Although the short-term risks are minimal, the long-term risks of radiation-induced de novo secondary neoplasms or malignant progression of the primary benign tumor need to be considered.
  • There are currently 19 reported cases of tumors linked with stereotactic radiotherapy/radiosurgery, to which we add our second institutional experience of a patient who succumbed to a glioblastoma multiforme (GBM) after stereotactic radiotherapy for an acoustic neuroma (AN).
  • Review of these 20 cases revealed 10 de novo secondary tumors, of which eight were malignant, with six being malignant gliomas.
  • The majority of the cases (14 of 20) involved AN, with most being in patients with neurofibromatosis-2 (NF2; 8 of 14), reflecting the large numbers and long-term use of radiotherapy for AN.
  • Accelerated growth of the primary benign AN, some 2 to 6 years after focused radiotherapy, was found in six of eight NF2 patients, with pathological verification of a malignant nerve sheath tumor documented in most.
  • [MeSH-major] Brain Neoplasms / etiology. Glioblastoma / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


77. Attias J, Nageris B, Ralph J, Vajda J, Rappaport ZH: Hearing preservation using combined monitoring of extra-tympanic electrocochleography and auditory brainstem responses during acoustic neuroma surgery. Int J Audiol; 2008 Apr;47(4):178-84
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  • [Title] Hearing preservation using combined monitoring of extra-tympanic electrocochleography and auditory brainstem responses during acoustic neuroma surgery.
  • The combined ABR and tympanic membrane (TM) ECochG testing was performed in 74 patients undergoing acoustic neuroma (AN) surgery.
  • In addition, EMG recordings were conducted to monitor the facial nerve function.
  • Hearing was preserved in 19 of the 30 patients with residual hearing prior to surgery (63%), and facial nerve function was maintained in 89% of the patients.
  • In most cases, the presence of both auditory brainstem and TM-ECochG responses at the end of surgery was associated with preservation of postoperative functional hearing; however, eight patients had a TM-ECochG response with a complete loss of the ABR, pointing to deafferentation of the auditory nerve.
  • [MeSH-major] Audiometry, Evoked Response / methods. Ear Neoplasms / surgery. Evoked Potentials, Auditory, Brain Stem / physiology. Monitoring, Intraoperative. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve / physiology. Female. Hearing Disorders / diagnosis. Hearing Disorders / epidemiology. Hearing Disorders / etiology. Hearing Tests. Humans. Male. Middle Aged. Otologic Surgical Procedures / methods. Prevalence. Severity of Illness Index

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  • (PMID = 18389413.001).
  • [ISSN] 1708-8186
  • [Journal-full-title] International journal of audiology
  • [ISO-abbreviation] Int J Audiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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78. Grainger J, Dias PS: Case report: optic disc edema without hydrocephalus in acoustic neuroma. Skull Base; 2005 Feb;15(1):83-6; discussion 86-8
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  • [Title] Case report: optic disc edema without hydrocephalus in acoustic neuroma.
  • Traditionally, visual disturbance and optic disc edema are regarded as late manifestations of acoustic neuromas indicating increased intracranial pressure as a result of obstructive hydrocephalus or a sizeable mass lesion.
  • Magnetic resonance imaging showed a large acoustic neuroma.
  • However, there was no ventriculomegaly and at surgery intracranial pressure was normal.
  • Furthermore, patients with acoustic neuromas and a visual disturbance related to optic disc edema may be inappropriate for treatment with stereotactic radiosurgery and should be offered early surgery to prevent visual deterioration.

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  • (PMID = 16148986.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1151706
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79. Schankin CJ, Gall C, Straube A: Headache syndromes after acoustic neuroma surgery and their implications for quality of life. Cephalalgia; 2009 Jul;29(7):760-71
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  • [Title] Headache syndromes after acoustic neuroma surgery and their implications for quality of life.
  • The patients of this prospective study were analysed for headache as a sequela of surgery for acoustic neuroma (AN).
  • The attempt to categorize the headaches according to the second edition of the International Classification of Headache Disorders revealed five headache syndromes, the most prevalent being tension-type-like headache (46.7%), followed by neuralgia of the occipital nerve (16.6%), trigeminal neuropathy (16.6%), neuropathy of the intermedian nerve (10.0%) and cervicogenic headache (10.0%).
  • [MeSH-major] Craniotomy / adverse effects. Headache Disorders / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / etiology


80. Kulac M, Karaca S, Acar M, Albayrak R, Songur A: Acquired port-wine stain related to acoustic neuroma. Clin Exp Dermatol; 2006 Jan;31(1):30-2
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  • [Title] Acquired port-wine stain related to acoustic neuroma.
  • Here we report the first case of a patient who had an acquired port-wine stain related to a solid brain tumour.
  • [MeSH-major] Neuroma, Acoustic / complications. Port-Wine Stain / etiology

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  • (PMID = 16309474.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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81. Nikolopoulos TP, Fortnum H, O'Donoghue G, Baguley D: Acoustic neuroma growth: a systematic review of the evidence. Otol Neurotol; 2010 Apr;31(3):478-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acoustic neuroma growth: a systematic review of the evidence.
  • AIM: To undertake a systematic review of the literature on acoustic neuroma growth.
  • RESULTS: The percentage of acoustic neuromas exhibiting growth ranges widely from 18 to 73%.
  • The percentage of tumors reported not to grow for some years after diagnosis ranges from 9 to 75%.
  • The mean growth rate for all tumors varies between 1 and 2 mm/yr, and for only those that grow, between 2 and 4 mm/yr.
  • There are various patterns of growth, and a tumor that shows growth may stop doing so and vice versa.
  • Finally, some tumors that have been stable for many years can exhibit tumor growth.
  • CONCLUSION: The growth pattern of acoustic neuromas is variable and incompletely understood.
  • As much as 75% of tumors have been reported to show no growth, supporting a "wait and rescan" policy in many patients, although there are no reliable predictors of tumor behavior, and some tumors may grow rapidly.
  • [MeSH-major] Neuroma, Acoustic / pathology


82. Goodden JR, Tranter R, Hardwidge C: Setting the standard--UK neurosurgical acoustic neuroma practice. Ann R Coll Surg Engl; 2006 Sep;88(5):486-9
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  • [Title] Setting the standard--UK neurosurgical acoustic neuroma practice.
  • INTRODUCTION: The aim of this study was to determine how current practice in the UK and Ireland complies with the Clinical Effectiveness Guidelines for the Management of Acoustic Neuromas.
  • RESULTS: Fifty-six neurosurgeons treat acoustic neuromas in 33 out of 34 units.
  • All surgeons use facial nerve monitoring during surgery.
  • [MeSH-major] Guideline Adherence / standards. Neuroma, Acoustic / surgery. Neurosurgical Procedures / standards. Practice Guidelines as Topic / standards. Professional Practice / standards

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  • (PMID = 17002857.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1964694
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83. Han YY, Kano H, Davis DL, Niranjan A, Lunsford LD: Cell phone use and acoustic neuroma: the need for standardized questionnaires and access to industry data. Surg Neurol; 2009 Sep;72(3):216-22; discussion 222
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  • [Title] Cell phone use and acoustic neuroma: the need for standardized questionnaires and access to industry data.
  • BACKGROUND: The capacity of radiofrequency from cell phones to be absorbed into the brain has prompted concerns that regular cell phone use may increase the risk of acoustic neuroma (AN) and other brain tumors.
  • This article critically evaluates current literature on cell phone use and AN risks and proposes additional studies to clarify any possible linkage.
  • METHODS: Through a PubMed search, we identified and reviewed 10 case-control studies and 1 cohort study of AN risks associated with cell phone use and a meta-analysis of long-term mobile phone use and its association with AN and other brain tumors.
  • RESULTS: Most studies did not find association between the development of AN and cell phone use, but some studies that followed cases for 10 years or more did show an association.
  • Among 10 case-control studies, odds ratios for AN associated with regular cell phone use ranged from 0.5 (95% confidence interval [CI], 0.2-1.0) to 4.2 (95% CI, 1.8-10).
  • Cell phone use was not associated with increased risk for AN in the Danish cohort study, which excluded business users from their study.
  • The meta-analysis, which included 3 case-control studies, found that subjects who used cell phones for at least 10 years had a 2.4-fold greater risk of developing ipsilateral AN.
  • In general, retrospective studies are limited in the ability to assess cell phone exposure because of recall bias and misclassification.
  • Some studies of longer term cell phone use have found an increased risk of ipsilateral AN.
  • Adopting a prospective approach to acquire data on cell phone use, obtaining retrospective billing records that provide independent evaluations of exposures, and incorporating information on other key potential risk factors from questionnaires could markedly advance the capacity of studies to evaluate the impact of cell phones on AN.
  • [MeSH-major] Brain / radiation effects. Cell Phones. Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / etiology. Neurosurgical Procedures / methods. Radiation. Surveys and Questionnaires
  • [MeSH-minor] Brain Mapping. Brain Neoplasms / epidemiology. Brain Neoplasms / etiology. Case-Control Studies. Cohort Studies. Glioma / epidemiology. Glioma / etiology. Great Britain / epidemiology. Humans. Incidence. Industry. Meningeal Neoplasms / epidemiology. Meningeal Neoplasms / etiology. Meningioma / epidemiology. Meningioma / etiology. Meta-Analysis as Topic. Odds Ratio. Risk Factors. Technology / trends. Time Factors. United States / epidemiology

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  • (PMID = 19328527.001).
  • [ISSN] 1879-3339
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 32
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84. Ondik MP, Benson AG, Djalilian H: An unusual site of a CSF leak following resection of a retrosigmoid acoustic neuroma. Ear Nose Throat J; 2006 Mar;85(3):164, 166-7
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  • [Title] An unusual site of a CSF leak following resection of a retrosigmoid acoustic neuroma.
  • Cerebrospinal fluid (CSF) leaks may occur after acoustic neuroma resection.
  • We describe a case of an infracochlear CSF leak that developed following the retrosigmoid resection of an acoustic neuroma.
  • [MeSH-major] Cerebrospinal Fluid Rhinorrhea / etiology. Cerebrospinal Fluid Rhinorrhea / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Postoperative Complications / surgery

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  • (PMID = 16615598.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma. Neurosurgery; 2006 Jul 01;59(1):E206
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  • [Title] Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma.

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  • (PMID = 28180621.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Myrseth E, Møller P, Wentzel-Larsen T, Goplen F, Lund-Johansen M: Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life. Neurosurgery; 2006 Jul 01;59(1):67-76
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  • [Title] Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life.

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  • (PMID = 28180608.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Hasegawa T, Kida Y, Yoshimoto M, Koike J, Goto K: TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas. Neurosurgery; 2006 Jun 01;58(6):1119-1128
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  • [Title] TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas.

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  • (PMID = 28173267.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Schoemaker MJ, Swerdlow AJ, Ahlbom A, Auvinen A, Blaasaas KG, Cardis E, Christensen HC, Feychting M, Hepworth SJ, Johansen C, Klaeboe L, Lönn S, McKinney PA, Muir K, Raitanen J, Salminen T, Thomsen J, Tynes T: Mobile phone use and risk of acoustic neuroma: results of the Interphone case-control study in five North European countries. Br J Cancer; 2005 Oct 3;93(7):842-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mobile phone use and risk of acoustic neuroma: results of the Interphone case-control study in five North European countries.
  • There is public concern that use of mobile phones could increase the risk of brain tumours.
  • If such an effect exists, acoustic neuroma would be of particular concern because of the proximity of the acoustic nerve to the handset.
  • We conducted, to a shared protocol, six population-based case-control studies in four Nordic countries and the UK to assess the risk of acoustic neuroma in relation to mobile phone use.
  • Data were collected by personal interview from 678 cases of acoustic neuroma and 3553 controls.
  • The risk of acoustic neuroma in relation to regular mobile phone use in the pooled data set was not raised (odds ratio (OR) = 0.9, 95% confidence interval (CI): 0.7-1.1).
  • The study suggests that there is no substantial risk of acoustic neuroma in the first decade after starting mobile phone use.
  • [MeSH-major] Cell Phones. Neuroma, Acoustic / etiology

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  • (PMID = 16136046.001).
  • [ISSN] 0007-0920
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2361634
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89. Stripf T, Mann WJ: [Ocular tilt reaction. A rare complication after acoustic neuroma surgery]. HNO; 2005 Dec;53(12):1077-80
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  • [Title] [Ocular tilt reaction. A rare complication after acoustic neuroma surgery].
  • Visual disturbances after acoustic neuroma surgery are very rare complications.
  • We present a patient with diplopia after a middle fossa approach for resection of an acoustic neuroma.
  • It is generally agreed that this reaction is secondary to a dysfunction of the tonic bilateral vestibular inputs that stabilize the eyes and head in a normal upright position in the roll plane.
  • It has also been described after denervation of the utricle and injury of the brain stem.
  • [MeSH-major] Diplopia / diagnosis. Diplopia / etiology. Neuroma, Acoustic / surgery. Neurosurgical Procedures / adverse effects

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  • (PMID = 15660240.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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90. Kernohan MD, Blackmore KJ, Johnson IJ, Zammit-Maempel I: Magnetic resonance imaging: is a single scan ever enough for the diagnosis of acoustic neuroma? J Laryngol Otol; 2006 Dec;120(12):1061-3
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  • [Title] Magnetic resonance imaging: is a single scan ever enough for the diagnosis of acoustic neuroma?
  • The MRI scan was initially negative but when repeated seven years later, following a further deterioration of symptoms, it showed a 2 mm, right-sided acoustic neuroma.
  • This case has great potential significance for the diagnosis of acoustic neuroma, and it may raise medico-legal issues regarding the exclusion of this diagnosis.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroma, Acoustic / diagnosis

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  • (PMID = 17059619.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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91. Andersen HT, Schrøder SA, Bonding P: Unilateral deafness after acoustic neuroma surgery: subjective hearing handicap and the effect of the bone-anchored hearing aid. Otol Neurotol; 2006 Sep;27(6):809-14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral deafness after acoustic neuroma surgery: subjective hearing handicap and the effect of the bone-anchored hearing aid.
  • OBJECTIVE: To evaluate the subjective hearing handicap in patients with unilateral deafness after acoustic neuroma surgery and the effect of the Bone-anchored Hearing Aid (BAHA) on test band.
  • STUDY DESIGN: Fifty-nine consecutive patients with unilateral deafness after translabyrintine removal of an acoustic neuroma, treated in Denmark in 2001 and 2002, were included.
  • CONCLUSION: This study shows that unilateral deafness after acoustic neuroma surgery is thought as a handicap in most of the patients and confirms that treatment with the BAHA has positive subjective effects and improves speech discrimination in noise.
  • Data from centers that perform simultaneous acoustic neuroma surgery and implantation for BAHA are necessary for firm conclusions.
  • [MeSH-major] Bone Conduction. Hearing Aids. Hearing Loss, Unilateral / etiology. Hearing Loss, Unilateral / therapy. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects

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  • (PMID = 16885786.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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92. Schoemaker MJ, Swerdlow AJ, Auvinen A, Christensen HC, Feychting M, Johansen C, Klaeboe L, Lönn S, Salminen T, Tynes T: Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. Int J Cancer; 2007 Jan 1;120(1):103-10
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  • [Title] Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study.
  • Acoustic neuroma (vestibular schwannoma) is a benign tumor of the vestibulocochlear nerve.
  • Its recorded incidence is increasing but risk factors for this tumor have scarcely been investigated.
  • We conducted a population-based case-control study of risk factors for acoustic neuroma in the UK and Nordic countries, including 563 cases and 2,703 controls.
  • Tumor risk was analyzed in relation to medical history and cigarette smoking.
  • Risk of acoustic neuroma was significantly raised in parous compared with nulliparous women (OR = 1.7, 95% CI: 1.1-2.6), but was not related to age at first birth or number of children.
  • Risk was not associated with a history of allergic disease, past head injury, past diagnosis of a neoplasm or birth characteristics, but was significantly raised for past diagnosis of epilepsy (OR = 2.5, 95% CI: 1.3-4.9).
  • Tumor risk was significantly reduced in subjects who had ever regularly smoked cigarettes (OR = 0.7, 95% CI: 0.6-0.9), but the reduction applied only to current smokers (OR = 0.5, 95% CI: 0.4-0.6), not ex-smokers (OR = 1.0, 95% CI: 0.8-1.3).
  • The reduced risk of acoustic neuroma in smokers and raised risk in parous women might relate to sex hormone levels, or smoking might suppress tumor growth, but effects of parity and smoking on timing of diagnosis of the tumor are also a potential explanation.
  • The raised risk in relation to past diagnosis of epilepsy might be a surveillance artefact or imply that epilepsy and/or antiepileptic medication use predispose to acoustic neuroma.
  • [MeSH-major] Neuroma, Acoustic / etiology. Smoking / adverse effects


93. Dublin A: Acoustic neuroma or vestibular schwannoma? Skull Base; 2009 Sep;19(5):375
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  • [Title] Acoustic neuroma or vestibular schwannoma?

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  • (PMID = 20190950.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765706
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94. Brooker J, Burney S, Fletcher J, Dally M: A qualitative exploration of quality of life among individuals diagnosed with an acoustic neuroma. Br J Health Psychol; 2009 Sep;14(Pt 3):563-78
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A qualitative exploration of quality of life among individuals diagnosed with an acoustic neuroma.
  • OBJECTIVES: To explore quality of life outcomes and the factors that influenced adjustment among individuals diagnosed with an acoustic neuroma.
  • METHODS: Twenty-one participants who had been diagnosed with and/or treated for an acoustic neuroma since 2000 attended one of four focus groups.
  • [MeSH-major] Adaptation, Psychological. Neuroma, Acoustic / psychology. Quality of Life / psychology

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  • (PMID = 19055870.001).
  • [ISSN] 1359-107X
  • [Journal-full-title] British journal of health psychology
  • [ISO-abbreviation] Br J Health Psychol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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95. Smouha EE, Yoo M, Mohr K, Davis RP: Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm. Laryngoscope; 2005 Mar;115(3):450-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm.
  • OBJECTIVES/HYPOTHESES: Conservative management is a viable treatment alternative for acoustic neuroma.
  • METHODS: Published studies on conservative management of acoustic neuroma were found using a key word search through PubMed in addition to the bibliographies of these selected studies.
  • A spreadsheet was made to tabulate the selection criteria for conservative management, duration and frequency of follow-up, patient demographics, initial tumor size and rate of growth, change in hearing status, and the need for definitive treatment.
  • The average initial tumor size was 11.8 mm (n = 900); 43% of 1,244 acoustic neuromas showed growth, whereas 57% showed either no growth or tumor regression.
  • CONCLUSIONS: Our meta-analysis supports the role of conservative management of acoustic neuromas in properly selected patients on the basis of a slow overall rate of growth and a substantial incidence of no growth.
  • An algorithm for acoustic neuroma management is proposed based on initial tumor size, patient age, and hearing status.
  • [MeSH-major] Algorithms. Neuroma, Acoustic / therapy

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  • [CommentIn] Laryngoscope. 2005 Sep;115(9):1704; author reply 1704 [16148723.001]
  • (PMID = 15744156.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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96. Bergson E, Sataloff RT: Preoperative computerized dynamic posturography as a prognostic indicator of balance function in patients with acoustic neuroma. Ear Nose Throat J; 2005 Mar;84(3):154-6
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  • [Title] Preoperative computerized dynamic posturography as a prognostic indicator of balance function in patients with acoustic neuroma.
  • We conducted a study to determine the prognostic reliability of preoperative computerized dynamic posturography (CDP) in patients undergoing surgical excision of an acoustic neuroma.
  • [MeSH-major] Diagnosis, Computer-Assisted. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Posture. Sensation Disorders / diagnosis
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neurosurgical Procedures / methods. Postural Balance / physiology. Predictive Value of Tests. Preoperative Care / methods. Retrospective Studies. Risk Assessment. Sensitivity and Specificity. Treatment Outcome. Vestibular Function Tests

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  • (PMID = 15871583.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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97. Kim AH, Edwards BM, Telian SA, Kileny PR, Arts HA: Transient evoked otoacoustic emissions pattern as a prognostic indicator for hearing preservation in acoustic neuroma surgery. Otol Neurotol; 2006 Apr;27(3):372-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transient evoked otoacoustic emissions pattern as a prognostic indicator for hearing preservation in acoustic neuroma surgery.
  • OBJECTIVE: To determine whether pre-operative transient otoacoustic emission (TEOAE) patterns are predictive of successful hearing preservation in acoustic neuroma surgery.
  • PATIENTS: A convenience sample was identified in whom pre-operative TEOAE data were available in patients undergoing acoustic neuroma surgery from 1993-2004.
  • Other variables of prognostic significance to hearing preservation in our series included smaller tumor size, tumor location within the IAC, better pre-operative hearing, and shorter latencies on ABR.
  • CONCLUSION: A robust pre-operative TEOAE frequency band pattern may be used as a favorable prognostic indicator for potential hearing preservation in acoustic neuroma surgery.
  • The prognostic value may be enhanced when combined with other prognostic factors such as tumor size, tumor location, pre-operative ABR and audiometric results.
  • [MeSH-major] Auditory Threshold. Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otoacoustic Emissions, Spontaneous / physiology
  • [MeSH-minor] Adolescent. Adult. Aged. Facial Nerve Diseases / etiology. Female. Humans. Logistic Models. Male. Middle Aged. Predictive Value of Tests. Preoperative Care. Prognosis. Retrospective Studies. Treatment Outcome

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  • (PMID = 16639277.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Lin V, Jacobson M, Dorion J, Chen J, Nedzelski J: Global assessment of outcomes after varying reinnervation techniques for patients with facial paralysis subsequent to acoustic neuroma excision. Otol Neurotol; 2009 Apr;30(3):408-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Global assessment of outcomes after varying reinnervation techniques for patients with facial paralysis subsequent to acoustic neuroma excision.
  • OBJECTIVE: To determine whether there are objective and/or subjective differences in facial function, tongue function and quality of life in patients who have undergone 1) direct facial-to-facial (Primary, 4 patients), 2) direct facial-to-hypoglossal (End-to-End, 7 patients), 3) end-to-side facial-to-hypoglossal nerve anastomoses with sural nerve/greater auricular nerve interposition (End-to-Side with Interposition Graft, 7 patients), and 4) end-to-side facial-to-hypoglossal nerve anastomoses (End-to-Side, 7 patients) after acoustic neuroma excision.
  • METHODS: Twenty-five patients with complete facial paralysis after acoustic neuroma surgery who have also undergone 1 of 4 types of facial musculature reinnervation volunteered for the study.
  • CONCLUSION: Complete sacrifice of the ipsilateral hypoglossal nerve does present with clinically and statistically significant morbidity in patients.
  • [MeSH-major] Facial Nerve / surgery. Facial Paralysis / etiology. Facial Paralysis / surgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures. Postoperative Complications / surgery
  • [MeSH-minor] Adult. Anastomosis, Surgical. Disability Evaluation. Female. Functional Laterality / physiology. Humans. Hypoglossal Nerve / surgery. Male. Middle Aged. Quality of Life. Retrospective Studies. Surveys and Questionnaires. Tongue / innervation. Tongue / physiology. Treatment Outcome


99. Kalogeridi MA, Georgolopoulou P, Kouloulias V, Kouvaris J, Pissakas G: Long-term follow-up confirms the efficacy of linac radiosurgery for acoustic neuroma and meningioma patients. A single institution's experience. J BUON; 2010 Jan-Mar;15(1):68-73
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  • [Title] Long-term follow-up confirms the efficacy of linac radiosurgery for acoustic neuroma and meningioma patients. A single institution's experience.
  • PURPOSE: To investigate the long-term efficacy and toxicity in a group of consecutive patients treated with linear accelerator (linac) radiosurgery for acoustic neuromas and meningiomas.
  • METHODS: Between 2000 and 2004, 34 patients (median age 65.5 years, range 50-84) with acoustic neuroma or meningioma were treated with linac-based stereotactic radiosurgery with a surface dose of 11-15.5 Gy.
  • Median tumor volume was 5.95cm(3).
  • Nineteen (59%) tumors decreased in size and 13 (41%) remained stable.
  • None of the tumors increased in size in the long-term follow-up, resulting in an overall growth control of 100% for the small number of patients of our study.
  • CONCLUSION: Long-term follow-up confirms the efficacy and low toxicity of linac radiosurgery for neuroma and meningioma patients.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Particle Accelerators. Radiosurgery / instrumentation
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiation Dosage. Time Factors. Tomography, X-Ray Computed. Treatment Outcome. Tumor Burden

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  • (PMID = 20414930.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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100. Schwager K, Baier G, Helms J, Hagen R: [Results in otosurgically treated patients with acoustic neuroma. Part 2: Hearing results after middle fossa approach]. Laryngorhinootologie; 2008 Sep;87(9):629-33
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  • [Title] [Results in otosurgically treated patients with acoustic neuroma. Part 2: Hearing results after middle fossa approach].
  • [Transliterated title] Ergebnisse otochirurgisch operierter Patienten mit Akustikusneurinom. Teil 2: Hörergebnisse nach transtemporaler Resektion.
  • BACKGROUND: The surgical therapy of acoustic neuromas has been seen critically lately.
  • There was no difference between tumors confined to the inner ear canal and tumors extending into the cerebello pontine angle.
  • There was also no difference between tumors up to a volume of 100 mm3 and tumors between 100 mm3 and 500 mm3.
  • CONCLUSION: Acoustic neuroma confined to the internal meatus or with little extend into the cerebello pontine angle (i. e. no contact to structures of the brain stem or vessels of the posterior fossa) are feasible for resection via the middle fossa approach.
  • The possibility of hearing preservation and low morbidity makes it the treatment of choice for this group of tumors.
  • [MeSH-major] Hearing / physiology. Neuroma, Acoustic / surgery

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  • (PMID = 18421644.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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