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1. Matsuo T, Hayashi Y, Ujifuku K, Baba S, Kamada K, Hayashi N, Nagata I: [Radiation injury after stereotactic irradiaton: especially long-term follow-up benign of targets]. No Shinkei Geka; 2009 Dec;37(12):1201-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To analyses the result of linac radiosurgery (LRS) for the treatment of intracranial benign lesions and to assess possible factors related to complications.
  • Fifty-eight patients with vestibulan schwannoma (VS): Gr.
  • Imaging changes were seen mostly in cases with tumor volume greater than 5 cc.
  • CONCLUSION: LRS for each disease seems to be a safe and effective treatment.
  • [MeSH-major] Intracranial Arteriovenous Malformations / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 19999552.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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2. Mahrous AK, Kalepu R: Positive findings on MRI in patients with asymmetrical SNHL. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1471-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pickup rate was 1% for CPA lesion which was vestibular schwannoma.

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  • [Cites] Otolaryngol Head Neck Surg. 1990 Sep;103(3):364-70 [2122364.001]
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  • (PMID = 18478244.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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3. Schaedler A, Hawkins D: Audiologic management of a patient with a sudden hearing loss and vestibular schwannoma in the contralateral ear. J Am Acad Audiol; 2008 Mar;19(3):210-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Audiologic management of a patient with a sudden hearing loss and vestibular schwannoma in the contralateral ear.
  • The case of a 59-year-old male with a sudden-onset sensorineural hearing loss in one ear and an incidental finding of an intracanalicular vestibular schwannoma in the contralateral, normally hearing ear is reported.
  • [MeSH-major] Functional Laterality. Hearing Aids. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / therapy. Hearing Loss, Sudden / etiology. Hearing Loss, Sudden / therapy. Neuroma, Acoustic / etiology

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  • (PMID = 18672648.001).
  • [ISSN] 1050-0545
  • [Journal-full-title] Journal of the American Academy of Audiology
  • [ISO-abbreviation] J Am Acad Audiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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4. Okunaga T, Matsuo T, Hayashi N, Hayashi Y, Shabani HK, Kaminogo M, Ochi M, Nagata I: Linear accelerator radiosurgery for vestibular schwannoma: measuring tumor volume changes on serial three-dimensional spoiled gradient-echo magnetic resonance images. J Neurosurg; 2005 Jul;103(1):53-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linear accelerator radiosurgery for vestibular schwannoma: measuring tumor volume changes on serial three-dimensional spoiled gradient-echo magnetic resonance images.
  • OBJECT: The authors report on a series of 46 patients harboring vestibular schwannomas (VSs) treated using linear accelerator (LINAC) radiosurgery and an analysis of serial magnetic resonance (MR) imaging data, specifically the changes in tumor volume.
  • Tumor volume was measured on Gd-enhanced MR images of each slice.
  • Tumor volume changes were categorized into four types: enlargement (eight lesions [19%]), no change (two lesions [4.8%]), transient enlargement followed by shrinkage (19 lesions [45.2%]), and direct shrinkage (13 lesions [31%]).
  • Two cases (4.8%) with twice the initial tumor volume required repeated radiosurgery.
  • CONCLUSIONS: Volume measurement on 3D-SPGR MR imaging was a suitable method to assess tumor changes.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery / instrumentation

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  • (PMID = 16121973.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Akamatsu Y, Murakami K, Watanabe M, Jokura H, Tominaga T: Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations. World Neurosurg; 2010 Jun;73(6):751-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations.
  • BACKGROUND: Gamma knife radiosurgery (GKRS) is an effective treatment for vestibular schwannomas with lower morbidity and mortality.
  • METHODS: We describe a case presenting with malignant peripheral nerve sheath tumor (MPNST) at 8 years after GKRS after incomplete resections.
  • RESULTS: The tumor appeared to be a typical benign schwannoma at the surgery preceding GKRS, and rapidly enlarged after long-term control, causing progressive neurological deterioration.
  • Operative findings showed that the tumor was composed of two different components, and histopathology distinctively demonstrated MPNST and benign schwannoma.
  • CONCLUSIONS: The coexistence of benign and malignant components might indicate that the present MPNST had arisen from the benign schwannoma by transformation in association with GKRS.
  • [MeSH-major] Mixed Tumor, Malignant / etiology. Mixed Tumor, Malignant / pathology. Neoplasms, Radiation-Induced / pathology. Nerve Sheath Neoplasms / etiology. Nerve Sheath Neoplasms / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic / pathology. Cell Transformation, Neoplastic / radiation effects. Female. Humans. Neurosurgical Procedures / methods. Radiation Injuries / diagnosis. Radiation Injuries / pathology. Reoperation / methods. Treatment Failure. Treatment Outcome. Vestibular Nerve / pathology. Vestibular Nerve / radiation effects. Vestibular Nerve / surgery


6. Schwarz C, Dang Burgener NP, Dosso AA: [OCT Visante observation of the progression of a perforated neurotrophic cornea ulcer treated with amniotic membrane grafts]. J Fr Ophtalmol; 2008 Apr;31(4):419-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Observation à l'OCT Visante de l'évolution d'un ulcère cornéen neurotrophique perforant traité par greffes de membranes amniotiques.
  • METHODS: A 71-year-old patient with facial nerve paresis secondary to vestibular schwannoma surgery presented with a neurotrophic perforated corneal ulcer.
  • [MeSH-minor] Aged. Disease Progression. Humans. Male

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  • (PMID = 18563043.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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7. Kanayama S, Kohno M, Okamura K, Yoshino M, Segawa H, Saito I, Sano K: [Case of hydrocephalus associated with vestibular schwannoma, treated by tumor removal]. No Shinkei Geka; 2006 Apr;34(4):391-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Case of hydrocephalus associated with vestibular schwannoma, treated by tumor removal].
  • A computerized tomographic scan (CT) and magnetic resonance imaging (MRI) revealed hydrocephalus as well as a tumor in the right cerebellopontine angle.
  • We diagnosed communicating-type hydrocephalus associated with the vestibular schwannoma and tumor removal was performed prior to ventriculo-peritoneal (V-P) shunt.
  • Hydrocephalus is occasionally complicated by vestibular schwannoma.
  • The majority results from obstruction of the cerebrospinal fluid (CSF) pathway by large tumors.
  • But, small tumors also cause communicating-type hydrocephalus.
  • Although the selection of the treatment is controversial, tumor removal without a shunt is considered as a good strategy for management of hydrocephalus associated with vestibular schwannoma.
  • [MeSH-major] Hydrocephalus / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery


8. Sakai T, Vallejo MC, Shannon KT: A parturient with neurofibromatosis type 2: anesthetic and obstetric considerations for delivery. Int J Obstet Anesth; 2005 Oct;14(4):332-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis type 2 is an extremely rare form of neurofibromatosis characterized by central nervous system involvement with bilateral vestibular schwannomas and spinal tumors.
  • Anesthetic management of a parturient with neurofibromatosis type 2 has not been fully reported, and the condition is challenging to obstetric anesthesiologists due to the presence of intracranial and intraspinal canal neurofibromas.


9. Springborg JB, Poulsgaard L, Thomsen J: Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines. Skull Base; 2008 Jul;18(4):217-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines.
  • The most common cerebellopontine angle (CPA) tumor is a vestibular schwannoma, but one in five CPA tumors are not vestibular schwannomas.
  • These tumors may require different management strategies.
  • Compared with vestibular schwannomas, symptoms and signs from cranial nerve VIII are less frequent: other cranial nerve and cerebellar symptoms and signs predominate in patients with these less common CPA tumors.
  • This review provides a structured approach to the diagnosis of nonvestibular schwannoma CPA lesions and also management guidelines.

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  • (PMID = 19119337.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2467479
  • [Keywords] NOTNLM ; Cerebellopontine angle / epidermoids / management guidelines / meningiomas / tumors
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10. Lunsford LD, Niranjan A, Flickinger JC, Kondziolka D: Navigating change and the acoustic neuroma story: methods, outcomes, and myths. Clin Neurosurg; 2008;55:47-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Navigating change and the acoustic neuroma story: methods, outcomes, and myths.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Follow-Up Studies. Humans. Magnetic Resonance Imaging. Microsurgery / methods. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / surgery. Neoplasm, Residual / diagnosis. Neoplasm, Residual / surgery. Postoperative Complications / etiology. Reoperation

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  • (PMID = 19248668.001).
  • [ISSN] 0069-4827
  • [Journal-full-title] Clinical neurosurgery
  • [ISO-abbreviation] Clin Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 110
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11. Merkus P, Sanna M: Conservative or surgical treatment of a vestibular schwannoma. Otol Neurotol; 2010 Apr;31(3):548
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative or surgical treatment of a vestibular schwannoma.
  • [MeSH-major] Neuroma, Acoustic / surgery

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  • [CommentOn] Otol Neurotol. 2009 Jun;30(4):507-14 [19373122.001]
  • (PMID = 19887976.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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12. Lenarz T, Lim H, Joseph G, Reuter G, Lenarz M: [Central auditory prosthesis]. HNO; 2009 Jun;57(6):551-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Deaf patients with severe sensory hearing loss can benefit from a cochlear implant (CI), which stimulates the auditory nerve fibers.
  • However, patients who do not have an intact auditory nerve cannot benefit from a CI.
  • The majority of these patients are neurofibromatosis type 2 (NF2) patients who developed neural deafness due to growth or surgical removal of a bilateral acoustic neuroma.
  • [MeSH-major] Deafness / rehabilitation. Deep Brain Stimulation / instrumentation. Deep Brain Stimulation / methods. Prostheses and Implants

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  • (PMID = 19517084.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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13. Hadfield KD, Smith MJ, Urquhart JE, Wallace AJ, Bowers NL, King AT, Rutherford SA, Trump D, Newman WG, Evans DG: Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas. Oncogene; 2010 Nov 25;29(47):6216-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas.
  • Biallelic inactivation of the NF2 gene occurs in the majority of schwannomas.
  • We have performed DNA sequence and dosage analysis of the NF2 gene in a panel of 239 schwannoma tumours: 97 neurofibromatosis type 2 (NF2)-related schwannomas, 104 sporadic vestibular schwannomas (VS) and 38 schwannomatosis-related schwannomas.
  • LOH was present in 28 out of 34 (82%) schwannomatosis-related schwannomas.
  • This study shows that MR is a mechanism of LOH in NF2 and SMARCB1-negative schwannomatosis-related schwannomas, occurring less frequently in sporadic vs. We found no evidence of MR in SMARCB1-positive schwannomatosis, suggesting that susceptibility to MR varies according to the disease context.
  • [MeSH-minor] Adolescent. Adult. Child. Chromosome Breakpoints. Gene Dosage / genetics. Genes, Neurofibromatosis 2. Homozygote. Humans. Neurilemmoma / genetics. Neurofibromatoses / genetics. Polymorphism, Single Nucleotide / genetics. Skin Neoplasms / genetics. Young Adult

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  • (PMID = 20729918.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] Schwannomatosis
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14. Kurowska-Mroczek E, Zabek M, Osuch B, Stelmachów J: Therapeutic management of acoustic neurinoma during twin pregnancy: a case report. J Reprod Med; 2009 Jun;54(6):393-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic management of acoustic neurinoma during twin pregnancy: a case report.
  • BACKGROUND: Acoustic neuromas belong to relatively rare illnesses in pregnant women.
  • Magnetic resonance imaging showed a vestibular acoustic neuroma of cranial nerve VII on the right side.
  • On the 14th postoperative day a team of neurosurgeons performed a right suboccipital craniectomy and completely removed the tumor.
  • CONCLUSION: The treatment of acoustic neuroma depends on the general health of a patient and the length of pregnancy.
  • If symptoms of intracranial compression quickly worsen, an immediate intervention is often required regardless of the pregnancy stage.
  • [MeSH-major] Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / surgery. Pregnancy, Multiple

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  • (PMID = 19639930.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Milham S: Meningioma and mobile phone use. Int J Epidemiol; 2010 Aug;39(4):1117; author reply 1119
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Cell Phones. Meningeal Neoplasms / etiology. Meningioma / etiology. Radio Waves / adverse effects
  • [MeSH-minor] Case-Control Studies. Female. Glioma / epidemiology. Humans. Male. Neuroma, Acoustic / epidemiology. Odds Ratio. Selection Bias. Sex Distribution

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  • [CommentIn] Int J Epidemiol. 2011 Aug;40(4):1122 [21216743.001]
  • [CommentOn] Int J Epidemiol. 2008 Dec;37(6):1304-13 [18676984.001]
  • (PMID = 19386823.001).
  • [ISSN] 1464-3685
  • [Journal-full-title] International journal of epidemiology
  • [ISO-abbreviation] Int J Epidemiol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
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16. Battista RA: Gamma knife radiosurgery for vestibular schwannoma. Otolaryngol Clin North Am; 2009 Aug;42(4):635-54
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  • [Title] Gamma knife radiosurgery for vestibular schwannoma.
  • Since Leksell first treated a patient who had a vestibular schwannoma in 1967, there has been a year-to-year increase in the number of patients treated with the gamma knife for vestibular schwannoma.
  • This article outlines the technique of GKRS and discusses the current results of its use to treat vestibular schwannomas.
  • Other topics discussed include tumor control, treatment of recurrent/residual and cystic vestibular schwannomas, and the results of treatment of neurofibromatosis type 2.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiation Injuries / prevention & control. Radiosurgery / methods
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Invasiveness / pathology. Neoplasm Staging. Patient Selection. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751869.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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17. Jeon CJ, Kong DS, Nam DH, Lee JI, Park K, Kim JH: Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma. J Clin Neurosci; 2010 Jul;17(7):862-4
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  • [Title] Communicating hydrocephalus associated with surgery or radiosurgery for vestibular schwannoma.
  • The purpose of this cohort study was to determine the incidence of communicating hydrocephalus (HCP) associated with the treatment of vestibular schwannoma (VS).
  • There was no significant correlation between sex or tumor size and the incidence of communicating HCP in the GKS group (p>0.05).
  • [MeSH-major] Hydrocephalus / etiology. Neuroma, Acoustic / surgery. Neurosurgical Procedures / adverse effects. Postoperative Complications / etiology. Radiosurgery / adverse effects


18. Sahu RN, Behari S, Agarwal VK, Giri PJ, Jain VK: Taste dysfunction in vestibular schwannomas. Neurol India; 2008 Jan-Mar;56(1):42-6
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  • [Title] Taste dysfunction in vestibular schwannomas.
  • BACKGROUND: Gustatory dysfunction associated with vestibular schwannomas (VS) is a poorly represented clinical presentation.
  • Preoperatively, taste disturbance was found in 29 (37.2%) giant, 28 (45.9%) large and one (33.3%) medium-sized tumors, respectively.
  • Among patients with anatomically preserved facial nerve, postoperative taste disturbances were found in 55 (42.3%) patients whereas nine (6.9%) patients reported improvement in taste sensations.
  • CONCLUSIONS: Taste dysfunction is common following vestibular schwannoma surgery.
  • Taste dysfunction should be included in the facial nerve functional grading system while assessing outcome.
  • [MeSH-major] Neuroma, Acoustic / complications. Taste Disorders / etiology

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  • (PMID = 18310836.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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19. Scheller C, Rampp S, Rachinger JC, Prell J, Koesling S, Becker S, Strauss C: Contrast enhancement and histopathological findings in vestibular schwannoma. Cent Eur Neurosurg; 2010 Feb;71(1):35-8
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  • [Title] Contrast enhancement and histopathological findings in vestibular schwannoma.
  • Changes of contrast uptake are considered to indicate the efficacy of therapy in irradiated vestibular schwannomas.
  • We present a case of a large vestibular schwannoma with heterogeneous contrast uptake on MRI.
  • Using neuronavigation, histological samples were obtained during surgery from an area with homogeneous contrast uptake and from a central tumor portion without contrast enhancement on MRI.
  • Intraoperative investigation found no evidence of necrotic tumor, and histopathological examination revealed an active tumor in both sections, with no central necrosis.
  • This finding illustrates the surgical experience that " necrotic tumor areas " on MRI may not be consistent with intraoperative findings.
  • Lack of contrast uptake in previously irradiated schwannomas may not be indicative of effective radiotherapy.
  • [MeSH-major] Ear Neoplasms / pathology. Ear Neoplasms / surgery. Magnetic Resonance Imaging / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 20201125.001).
  • [ISSN] 1868-4912
  • [Journal-full-title] Central European neurosurgery
  • [ISO-abbreviation] Cent Eur Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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20. Sauvaget E, Kici S, Kania R, Herman P, Tran Ba Huy P: Sudden sensorineural hearing loss as a revealing symptom of vestibular schwannoma. Acta Otolaryngol; 2005 Jun;125(6):592-5
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  • [Title] Sudden sensorineural hearing loss as a revealing symptom of vestibular schwannoma.
  • CONCLUSIONS: Sudden sensorineural hearing loss (SSHL) is a frequent symptom of vestibular schwannoma (VS), often reveals small VSs and does not exhibit specific features.
  • Therefore, every case of SSHL should be evaluated using systematic MRI to rule out VS in order to improve hearing and preservation facial nerve function.
  • MATERIAL AND METHODS: A total of 139 consecutive unilateral VSs operated on between 2000 and 2002 were reviewed and analyzed regarding the prevalence, clinical and audiological features of SSHL and their relation to the size of the tumor.
  • Tumor size was significantly smaller in SSHL-associated VSs compared to other VSs.
  • [MeSH-major] Hearing Loss, Sudden / etiology. Neuroma, Acoustic / complications
  • [MeSH-minor] Adult. Aged. Audiometry / classification. Cohort Studies. Dizziness / etiology. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Hearing / physiology. Humans. Male. Middle Aged. Neoplasm Staging. Petrous Bone / pathology. Recovery of Function / physiology. Retrospective Studies. Tinnitus / etiology. Vertigo / etiology


21. Sen A, Khan MI, Ramsden RT, Gillespie JE: Stenosis of the internal auditory meatus masquerading as bilateral vestibular schwannomas: a cautionary tale. J Laryngol Otol; 2005 Dec;119(12):995-7
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  • [Title] Stenosis of the internal auditory meatus masquerading as bilateral vestibular schwannomas: a cautionary tale.
  • They are known to symptomatically mimic vestibular schwannomas leading to potential diagnostic error.
  • We present a case (along with literature review) where a stenotic IAM was clinically and radiologically misdiagnosed as a vestibular schwannoma.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Ear, Inner. Labyrinth Diseases / diagnosis. Neuroma, Acoustic / diagnosis. Vestibulocochlear Nerve Diseases / diagnosis

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  • (PMID = 16354367.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 8
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22. Maruyama T, Muragaki Y, Hori T: [Surgical technique for vestibular schwannoma]. No Shinkei Geka; 2006 Jul;34(7):681-93
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  • [Title] [Surgical technique for vestibular schwannoma].
  • [MeSH-major] Neuroendoscopy / methods. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Radiosurgery

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  • (PMID = 16841704.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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23. Huang L, Xu WG, Fu YF, Gao W: [Magnetic resonance imaging diagnosis of occupied lesions in cerebellopontine angle area:a report of 78 cases]. Ai Zheng; 2005 May;24(5):591-5
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  • BACKGROUND & OBJECTIVE: It is difficult to diagnose cerebellopontine angle area tumor because of many sorts and origins of the tumor.
  • RESULTS: Of the 78 cases, 48 (61.5%) were unilateral acoustic neuroma, 5(6.4%) were bilateral acoustic neuroma, 12 (15.4%) were meningioma, 4 (5.1%) were trigeminal neuroma, 3 (3.8%) were hemangioblastoma, 3 (3.8%) were lipoma, 2 (2.6%) were melanoma, 1 (1.3%) was medulloblastoma.
  • According to the anatomic site, tumor lesion character, and MRI signal character, the majority of cerebellopontine angle area tumors were diagnosed accurately.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Cranial Nerve Neoplasms / diagnosis. Female. Humans. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Middle Aged. Neuroma / diagnosis. Trigeminal Nerve Diseases / diagnosis

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  • (PMID = 15890104.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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24. Dubey RB, Hanmandlu M, Gupta SK: Risk of brain tumors from wireless phone use. J Comput Assist Tomogr; 2010 Nov-Dec;34(6):799-807
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  • [Title] Risk of brain tumors from wireless phone use.
  • The debate regarding the health effects of low-intensity electromagnetic radiation from sources such as power lines, base stations, and cell phones has recently been reignited.
  • This article surveys the results of early cell phone studies, where exposure duration was too short to expect tumor genesis, and 2 sets of more recent studies with longer exposure duration: the Interphone studies and the Swedish studies led by Hardell.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Electromagnetic Fields / adverse effects. Neoplasms, Radiation-Induced / etiology
  • [MeSH-minor] Glioma / etiology. Humans. Neuroma, Acoustic / etiology. Risk Factors

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  • [RetractionIn] Elster AD. J Comput Assist Tomogr. 2013 Jan-Feb;37(1):123 [23321845.001]
  • (PMID = 21084892.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article; Retracted Publication; Review
  • [Publication-country] United States
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25. Kano H, Kondziolka D, Niranjan A, Flannery TJ, Flickinger JC, Lunsford LD: Repeat stereotactic radiosurgery for acoustic neuromas. Int J Radiat Oncol Biol Phys; 2010 Feb 1;76(2):520-7
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  • [Title] Repeat stereotactic radiosurgery for acoustic neuromas.
  • PURPOSE: To evaluate the outcome of repeat stereotactic radiosurgery (SRS) for acoustic neuromas, we assessed tumor control, clinical outcomes, and the risk of adverse radiation effects in patients whose tumors progressed after initial management.
  • METHODS AND MATERIALS: During a 21-year experience at our center, 1,352 patients underwent SRS as management for their acoustic neuromas.
  • We retrospectively identified 6 patients who underwent SRS twice for the same tumor.
  • All patients had imaging evidence of tumor progression despite initial SRS.
  • RESULTS: At a median follow-up of 29 months after the second SRS (range, 13-71 months), tumor control or regression was achieved in all 6 patients.
  • CONCLUSIONS: With this limited experience, we found that repeat SRS for a persistently enlarging acoustic neuroma can be performed safely and effectively.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Disease Progression. Humans. Magnetic Resonance Imaging. Middle Aged. Radiotherapy Dosage. Reoperation / utilization. Retrospective Studies


26. Snelling JD, Krywawych M, Majithia A, Harcourt JP: The compliance, true positive and false negative rates of the Charing Cross protocol for magnetic resonance imaging screening for cerebellopontine angle lesions. J Laryngol Otol; 2008 Mar;122(3):255-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry / methods. False Negative Reactions. False Positive Reactions. Female. Humans. Male. Middle Aged. Neuroma, Acoustic / diagnosis. Predictive Value of Tests. Referral and Consultation. Retrospective Studies. Treatment Outcome

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  • (PMID = 17498327.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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27. Yuguang L, Chengyuan W, Meng L, Shugan Z, Wandong S, Gang L, Xingang L: Neuroendoscopic anatomy and surgery of the cerebellopontine angle. J Clin Neurosci; 2005 Apr;12(3):256-60
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  • NEAMN tumour resection was performed in eight acoustic neuromas, one meningioma and 14 cholesteatomas and NEAMN vascular decompression was performed in five patients with trigeminal neuralgia.
  • Complete excision of the tumour with preservation of the facial nerve was achieved in all eight acoustic neuromas.
  • [MeSH-minor] Adult. Anesthesia, General. Cerebellar Diseases / pathology. Cerebellar Diseases / surgery. Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cholesteatoma / surgery. Decompression, Surgical. Endoscopy. Female. Humans. Male. Meningioma / surgery. Microsurgery. Middle Aged. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Trigeminal Neuralgia / surgery

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  • (PMID = 15851077.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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28. Régis J, Tamura M, Wikler D, Porcheron D, Levrier O: Radiosurgery: operative technique, pitfalls and tips. Prog Neurol Surg; 2008;21:54-64
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  • Topography of petrous structures such as cochlea, vestibulum and facial nerve canal should be visible on the CT scan.
  • High-resolution CISS T2-weighted volumetric pulse sequences (3DT2) allow direct nerve visualization and give superior stereotactic definition attributable to their better resolution minimizing partial volume effects and to their lower magnetic susceptibility minimizing distortions.
  • The 3DT2 pulse sequences with contrast injection, show improved distinction between the pons and the nerves due to signal differences within the schwannomas.
  • Tumor volume delineation allows the calculation of conformity, selectivity and gradient indexes.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / adverse effects. Radiosurgery / methods

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  • (PMID = 18810199.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 22
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29. Aghi M, Barker FG 2nd: Benign adult brain tumors: an evidence-based medicine review. Prog Neurol Surg; 2006;19:80-96
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  • [Title] Benign adult brain tumors: an evidence-based medicine review.
  • BACKGROUND: Benign adult brain tumors can be managed conservatively or using surgery, radiation, or medicines.
  • While randomized comparisons assessing tumor recurrence, quality of life, or survival are the ideal means of comparing treatments, it can be difficult to recruit patients to such trials and lengthy follow-up periods are needed because of the slowly progressive natural history of these tumors.
  • METHODS: Review of the literature on benign adult brain tumors using evidence-based standards and focusing on meningiomas, pituitary adenomas, and vestibular schwannomas, which together represent the majority of WHO grade 1 adult brain tumors.
  • RESULTS: Nearly all studies of benign adult brain tumors were of relatively poor quality (level 3 or poorer).
  • Vestibular schwannomas can be conservatively managed, but there are no reliable predictors of growth, so serial imaging is important.
  • Radiosurgery has proven to be a reliable alternative to surgery for small to medium-sized vestibular schwannomas, but followup has been relatively short in most studies to date.
  • CONCLUSIONS: While randomized clinical trials comparing conservative management, surgery, radiation, and medical management of benign adult benign tumors are unlikely to occur, there is some level 3 evidence that can assist in their treatment.
  • [MeSH-major] Brain Neoplasms / therapy. Evidence-Based Medicine
  • [MeSH-minor] Adenoma / therapy. Adult. Humans. Meningeal Neoplasms / therapy. Meningioma / therapy. Neuroma, Acoustic / therapy. Neurosurgical Procedures. Phototherapy. Pituitary Neoplasms / therapy. Radiosurgery

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  • (PMID = 17033148.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 58
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30. Gouveris H, Stripf T, Victor A, Mann W: Dynamic posturography findings predict balance status in vestibular schwannoma patients. Otol Neurotol; 2007 Apr;28(3):372-5
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  • [Title] Dynamic posturography findings predict balance status in vestibular schwannoma patients.
  • OBJECTIVE: To test whether condition 5 score (C5S) and condition 6 score (C6S) of the sensory organization test of computerized dynamic platform posturography (CDPP) differ between vestibular schwannoma (VS) patients with and without vestibular symptoms.
  • A hundred and twelve patients had a history of vertigo, dizziness, and/or imbalance, and 104 patients had neither present nor past vestibular symptoms at all.
  • Preoperative CDPP in VS patients with and without vestibular symptoms.
  • To test whether C5S and C6S differ between VS patients with and without vestibular symptoms, the Wilcoxon-Mann-Whitney rank sum test was applied.
  • RESULTS: Both C5S (p = 0.001) and C6S (p < 0.0005) were significantly lower in VS patients with vestibular symptoms than in VS patients without vestibular symptoms.
  • CONCLUSION: There is a significant difference in the distribution of C5S and C6S between VS patients with and without vestibular symptoms.
  • [MeSH-major] Neuroma, Acoustic / physiopathology. Neuroma, Acoustic / surgery. Postural Balance / physiology

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  • (PMID = 17159494.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Stojicic MT, Slavik EE, Acimovic GT, Jovanovic MD, Stojmirovic DM, Vujotic LD: Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report. J Plast Reconstr Aesthet Surg; 2008 Nov;61(11):e9-11
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  • [Title] Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report.
  • This article presents a successful surgical treatment of the patient with aggressive basal cell carcinoma with intracranial propagation (ulcer terebrans) and simultaneous acoustic neurinoma on the same side.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Neoplasms, Multiple Primary / surgery. Neuroma, Acoustic / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Brain / pathology. Female. Humans. Magnetic Resonance Imaging. Meninges / pathology. Middle Aged. Neoplasm Invasiveness. Reconstructive Surgical Procedures / methods. Scalp / pathology

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  • (PMID = 18718834.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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32. Diaz Anadon A, Lassaletta L, Roda JM, Gavilán Bouzas J: [CSF fistulae following surgery for cerebellopontine angle tumours and their relationship with the body mass index]. Acta Otorrinolaringol Esp; 2009 Sep-Oct;60(5):318-24
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  • [Transliterated title] Fístulas de LCR tras la cirugía de tumores del ángulo pontocerebeloso y su relación con el índice de masa corporal.
  • INTRODUCTION: The most frequent complication after vestibular schwannoma surgery is cerebrospinal fluid (CSF) fistula.
  • MATERIAL AND METHODS: Retrospective study of 170 patients who had vestibular schwannoma (163) or other tumours in the cerebello pontine angle (CPA) (7).
  • There might be other aetiological factors such as intracranial pressure.
  • [MeSH-major] Body Mass Index. Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Cerebrospinal Fluid Rhinorrhea / epidemiology. Cerebrospinal Fluid Rhinorrhea / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Postoperative Complications / etiology

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  • (PMID = 19814983.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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33. Yang I, Sughrue ME, Han SJ, Aranda D, Pitts LH, Cheung SW, Parsa AT: A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma. J Neurosurg; 2010 Apr;112(4):851-9
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  • [Title] A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma.
  • OBJECT: Gamma Knife surgery (GKS) has evolved into a practical alternative to open microsurgical resection in the treatment of patients with vestibular schwannoma (VS).
  • To mitigate institutional and practitioner bias, the authors performed an analytical review of the published literature on the GKS treatment of vestibular schwannoma patients.
  • 3) documentation of initial tumor size; and 4) GKS was the only radiosurgical modality in the treatment.
  • Hearing preservation and outcome data were then aggregated and analyzed based on the radiation dose, tumor volume, and patient age.
  • RESULTS: The 45 articles that met the authors' inclusion criteria represented 4234 patients in whom an overall hearing preservation rate was 51%, irrespective of radiation dose, patient age, or tumor volume.
  • Patients with smaller tumors (average tumor volume < or = 1.5 cm(3)) had a hearing preservation rate (62%) comparable with patients harboring larger tumors (61%) (p = 0.8968).
  • Furthermore, larger tumors and older patients do not appear to be at any increased risk for hearing loss after GKS for VS than younger patients or patients with smaller tumors.
  • [MeSH-major] Hearing Loss / epidemiology. Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / adverse effects. Radiosurgery / statistics & numerical data


34. Merkus P, Taibah A, Sequino G, Sanna M: Less than 1% cerebrospinal fluid leakage in 1,803 translabyrinthine vestibular schwannoma surgery cases. Otol Neurotol; 2010 Feb;31(2):276-83
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  • [Title] Less than 1% cerebrospinal fluid leakage in 1,803 translabyrinthine vestibular schwannoma surgery cases.
  • OBJECTIVE: To determine the incidence rate of cerebrospinal fluid (CSF) leak after translabyrinthine vestibular schwannoma surgery since the alteration of the surgical procedure.
  • PATIENTS: A series of 1,803 patients who underwent translabyrinthine vestibular schwannoma surgery between 1993 and 2009.
  • INTERVENTION: Translabyrinthine and extended translabyrinthine vestibular schwannoma surgery.
  • CONCLUSION: The methods used in translabyrinthine vestibular schwannoma surgery in our center can reduce CSF leakage to an absolute minimum.
  • Compared with all large series, this could be a new era of translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Ear, Inner / surgery. Neuroma, Acoustic / cerebrospinal fluid. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods. Postoperative Complications / prevention & control

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  • (PMID = 20042905.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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35. Wu H, Chen Y, Wang ZY, Li W, Li JQ, Zhang L, Lu YJ: Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas. Neuroscience; 2010 Sep 29;170(1):149-55
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  • [Title] Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas.
  • Previous studies have demonstrated that merlin acts as a tumor suppressor by blocking Ras-mediated signaling.
  • However, the mechanism by which merlin controls cell proliferation has remained obscure.
  • Here we show that merlin deficient tumors exhibited loss of p21, concomitant with elevated CDKs/cyclin D1 levels in sporadic vestibular schwannomas (VS) from clinic patients.
  • Likewise, silencing of merlin gene expression in the cell lines resulted in down-regulation of p21.
  • Consistent with the observation that over-expression of merlin arrested cell growth at G1-phase, the current study indicates that merlin exerts its antiproliferative effect, at least in part, by maintaining p21 expression, and loss of p21 is a prominent feature of merlin deficient schwannomas.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p21 / physiology. Neurofibromin 2 / deficiency. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics. Neuroma, Acoustic / metabolism
  • [MeSH-minor] Animals. Cell Proliferation. Down-Regulation / genetics. Gene Knockdown Techniques. Humans. Mice. NIH 3T3 Cells. Tumor Cells, Cultured

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  • [Copyright] Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 20600642.001).
  • [ISSN] 1873-7544
  • [Journal-full-title] Neuroscience
  • [ISO-abbreviation] Neuroscience
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Neurofibromin 2
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36. Akamatsu Y, Sugawara T, Mikawa S, Saito A, Ono S, Takayama K, Jokura H, Seki H: Ruptured pseudoaneurysm following Gamma Knife surgery for a vestibular schwannoma. J Neurosurg; 2009 Mar;110(3):543-6
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  • [Title] Ruptured pseudoaneurysm following Gamma Knife surgery for a vestibular schwannoma.
  • A 75-year-old woman underwent Gamma Knife surgery (GKS) for a vestibular schwannoma.
  • This is the first report of aneurysm formation with pathological findings following GKS for a vestibular schwannoma.
  • [MeSH-major] Aneurysm, False / etiology. Aneurysm, Ruptured / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

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  • (PMID = 18976052.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. De Valck CF, Wuyts FL, Vanspauwen R, Walravens S, Van de Heyning PH: Conscientiousness in patients with Ménière's disease. Otol Neurotol; 2007 Apr;28(3):365-8
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  • [Title] Conscientiousness in patients with Ménière's disease.
  • OBJECTIVE: To assess whether a conscientious personality profile is more prevalent in patients with Ménière's disease (MD) in comparison with other vertigo patients.
  • PATIENTS: A total of 108 patients were included and subdivided into one of five pathology groups: MD, benign paroxysmal positional vertigo, vestibular neuritis, vestibular schwannoma, and posttraumatic nonbenign paroxysmal positional vertigo.
  • [MeSH-major] Meniere Disease / epidemiology. Meniere Disease / psychology. Personality
  • [MeSH-minor] Adaptation, Psychological. Cross-Sectional Studies. Female. Humans. Male. Middle Aged. Neuroma, Acoustic / epidemiology. Personality Inventory. Surveys and Questionnaires. Vertigo / epidemiology. Vestibular Neuronitis / epidemiology. Wounds and Injuries / epidemiology

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  • (PMID = 17414043.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Rohit, Piccirillo E, Jain Y, Augurio A, Sanna M: Preoperative predictive factors for hearing preservation in vestibular schwannoma surgery. Ann Otol Rhinol Laryngol; 2006 Jan;115(1):41-6
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  • [Title] Preoperative predictive factors for hearing preservation in vestibular schwannoma surgery.
  • OBJECTIVES: We performed a retrospective chart review to evaluate the various predictive factors for postoperative hearing preservation in the surgical management of vestibular schwannoma.
  • METHODS: Of 792 patients operated on for vestibular schwannoma between April 1987 and July 2002, 107 were candidates for hearing preservation surgery.
  • These patients were divided into group 1 (hearing preserved) and group 2 (hearing not preserved), and both of these groups were evaluated for age, sex, pure tone average, sound discrimination score, tumor size, and auditory brain stem response parameters.
  • RESULTS: Preoperative pure tone average and tumor size were the 2 predictive factors in our study.
  • On multiple regression analysis by backward elimination of nonsignificant factors, we found that tumor size is an independent predictive factor for postoperative hearing.
  • CONCLUSIONS: In our series, preoperative pure tone average and tumor size were found to be predictors of postoperative hearing levels.
  • [MeSH-major] Hearing / physiology. Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16466099.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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39. Magliulo G, Stasolla A, Parrotto D, Marini M: Modified translabyrinthine approach and hearing preservation: imaging evaluation. J Laryngol Otol; 2007 Aug;121(8):736-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • AIM: To establish if the computed tomography (CT) and magnetic resonance imaging (MRI) appearances of the vestibule, after the removal of vestibular schwannoma by a modified translabyrinthine approach, correlate with a successful outcome, defined as hearing preservation.
  • MATERIALS AND METHODS: Our study group consisted of 16 patients with vestibular schwannoma.
  • On MRI scans, the schwannoma, including the intracanalicular segment, were less than 2 cm in size in all the patients.
  • In the remaining nine patients, the schwannoma had spread to involve two-thirds of the meatus, sparing its lateral third.
  • RESULTS: The schwannoma was completely removed in all patients.
  • The MRI vestibular signal on the T2-weighted images was well depicted only in patients with hearing preservation.
  • Bony vestibular integrity was observed in the CT scans of all cases with hearing preservation, and also in three cases with failure of hearing preservation.
  • CONCLUSION: Our results confirm that total isolation and maintenance of an anatomically intact vestibule, as depicted by MRI examination, is one of the fundamental factors for successful preservation of hearing function following modified translabyrinthine approach schwannoma removal.
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures. Vestibule, Labyrinth / surgery

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  • (PMID = 17319988.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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40. Zhang Z, Wu H, Huang Q, Jia H, Wang Z: [Study of postoperative facial nerve function influenced by sterical position between facial nerve and vestibular schwannoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Apr;23(7):292-5
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  • [Title] [Study of postoperative facial nerve function influenced by sterical position between facial nerve and vestibular schwannoma].
  • OBJECTIVE: To study the postoperative facial nerve function influenced by sterical position between facial nerve (FN) and vestibular schwannoma (VS).
  • METHOD: A retrospective review was performed of 101 patients with unilateral VS, who underwent tumor total removal via enlarged translabyrinthine approach between 2003 and 2006.
  • Data concerning tumor stage based on tumor size, intra-operative sterical position between FN and VS which was classed on 4 types (type I: FN anterior to VS; type 2: anterior and superior to VS; type 3: superior to VS and type 4: posterior to VS), postoperative facial nerve function according to the House and Brackmann classification at days 7, 30, 90 and 180.
  • RESULT: The facial nerve was preserved anatomically in 98%.
  • Good facial function at days 180 was present in 73% and decreased along with the augmentation of tumor size.
  • The prognostic factor of latter includes not only tumor size, but also sterical position between FN and vs.
  • [MeSH-major] Facial Nerve / anatomy & histology. Neurilemmoma. Neuroma, Acoustic / surgery

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  • (PMID = 19670604.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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41. Muscat JE, Hinsvark M, Malkin M: Mobile telephones and rates of brain cancer. Neuroepidemiology; 2006;27(1):55-6
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  • [Title] Mobile telephones and rates of brain cancer.
  • The risk of most primary brain cancers including gliomas and acoustic neuromas is unrelated to the use of mobile telephones in several studies.
  • An increased risk caused by short-term mobile phone use was reported for neuroepithelial tumors, a rare histologic subgroup of brain cancers that are characterized by neuronal features.
  • [MeSH-major] Brain Neoplasms / epidemiology. Cell Phones / utilization. Ganglioglioma / epidemiology

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  • (PMID = 16825795.001).
  • [ISSN] 0251-5350
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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42. Saman Y, Bamiou DE, Gleeson M: A contemporary review of balance dysfunction following vestibular schwannoma surgery. Laryngoscope; 2009 Nov;119(11):2085-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A contemporary review of balance dysfunction following vestibular schwannoma surgery.
  • OBJECTIVES/HYPOTHESIS: This review aims to evaluate the literature pertaining to subjective balance dysfunction following vestibular schwannoma surgery; the effect of postoperative imbalance on disability, handicap and quality of life; and to determine factors that influence vestibular compensation.
  • METHODS: Ovid MEDLINE, Cochrane databases, and relevant contemporary texts were searched for papers relating to subjective balance dysfunction following vestibular schwannoma surgery.
  • RESULTS: The search yielded 26 studies assessing subjective balance dysfunction following vestibular schwannoma surgery.
  • CONCLUSIONS: Further study is needed of the factors that influence vestibular compensation following vestibular schwannoma surgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications. Postural Balance. Sensation Disorders

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  • (PMID = 19806649.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 47
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43. Browne S, Distel E, Morton RP, Petrie KJ: Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):417-22
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  • [Title] Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma.
  • OBJECTIVES: We compared the quality of life of patients with acoustic neuroma (AN) with general population controls and other chronic illness patients.
  • METHODS: A research questionnaire was sent to all 119 members of the Acoustic Neuroma Association of New Zealand.
  • However, most AN patients do report finding some benefit from their illness experience.
  • [MeSH-major] Hearing / physiology. Neuroma, Acoustic / psychology. Otologic Surgical Procedures / methods. Quality of Life

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  • (PMID = 19128648.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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44. Yonekawa Y: [On the occasion of my retirement as head of the Neurochirurgische Universitätsklinik Zürich--changing aspects of treatment modality in modern neurosurgery and of neuroscience research. Presentation of our experience and historical backgrounds]. Brain Nerve; 2008 May;60(5):538-46
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  • Traditionally, carotid endarterectomy belonged to vascular surgeons in our hospital, but the tendency of conversion from conventional carotid endarterectomy to endovascular PTA and/or stenting seemed to be marked, while microvascular revascularization procedure represented by extracranial intracranial EC-IC bypass remained constant (around 20/year) in various occasion (277 times on 203 cases: atherosclerosis 93, Moyamoya angiopathy (MMA) 47, aneurysm 57 and skull base tumour 6, during the last 13 years], in spite of negative results of EC-IC bypass international cooperative study for stroke prevention in 1985.
  • Acoustic neurinoma (just less than 20/year) is one of benign brain tumours whose treatment has changed remarkably.
  • Thanks to development of intaroperative neurophysiological monitoring and of surgical technique, preservation of facial nerve function has improved from 60% to more than 85% in spite of the increase of size.
  • [MeSH-minor] Brain Neoplasms / surgery. Cerebral Revascularization / methods. Cerebral Revascularization / trends. Humans. Hydrocephalus / surgery. Intracranial Aneurysm / surgery. Intracranial Arteriovenous Malformations / surgery. Switzerland. Universities

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  • (PMID = 18516976.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 33
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45. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. 2007. Neurosurg Clin N Am; 2008 Apr;19(2):331-43, vii
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  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas. 2007.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534343.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Bennett M; Haynes DS
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46. Kullar PJ, Pearson DM, Malley DS, Collins VP, Ichimura K: CpG island hypermethylation of the neurofibromatosis type 2 (NF2) gene is rare in sporadic vestibular schwannomas. Neuropathol Appl Neurobiol; 2010 Oct;36(6):505-14
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  • [Title] CpG island hypermethylation of the neurofibromatosis type 2 (NF2) gene is rare in sporadic vestibular schwannomas.
  • AIMS: Loss of both wild-type copies of the neurofibromatosis type 2 (NF2) gene is found in both sporadic and neurofibromatosis type 2-associated vestibular schwannomas (VS).
  • [MeSH-major] CpG Islands / genetics. DNA Methylation / genetics. Genes, Neurofibromatosis 2. Neuroma, Acoustic / genetics

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  • [Copyright] © 2010 The Authors. Neuropathology and Applied Neurobiology © 2010 British Neuropathological Society.
  • (PMID = 20831745.001).
  • [ISSN] 1365-2990
  • [Journal-full-title] Neuropathology and applied neurobiology
  • [ISO-abbreviation] Neuropathol. Appl. Neurobiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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47. Jeblaoui Y, Neji B, Haddad S, Mnif D, Hchicha S: [Difficulties of the management of head and neck neurofibromatosis]. Ann Chir Plast Esthet; 2007 Feb;52(1):43-50
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  • [Transliterated title] Difficultés de la prise en charge des atteintes de l'extrémité céphalique dans les neurofibromatoses.
  • Neurofibromatosis type 1 (NF1) or Von Recklinghausen's neurofibromatosis is an autosomal dominantly inherited disease, whose prevalence is 1/4500.
  • Neurofibromatosis type 2 (NF2) is also an autosomal dominantly inherited disease, but is ten times less frequent than the NF1 and is characterized by bilateral vestibular schwannomas (former acoustic neurinomas).
  • Surgical resection of the tumor was carried out among 8 patients with bone reconstruction of the orbit on 3 patients and cutaneous expansion on one other.
  • However, all our patients were satisfied with the result and we noted recurrence in a patient presenting a retro-auricular tumor, which filled the external auditory canal requiring a further surgery.
  • Cancer risks and the disease's completely unpredictable evolution urge a regular and multidisciplinary patient follow-up.

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  • (PMID = 17137698.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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48. Nolte I, Wessig C, Bendszus M: Fascicular hypoglossus nerve lesion. Neurology; 2006 Feb 14;66(3):441
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  • [Title] Fascicular hypoglossus nerve lesion.
  • [MeSH-major] Anastomosis, Surgical / adverse effects. Facial Nerve / surgery. Hypoglossal Nerve / surgery. Hypoglossal Nerve Injuries. Magnetic Resonance Imaging. Neuroma, Acoustic / surgery. Wounds, Penetrating / etiology

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  • [ErratumIn] Neurology. 2006 May 9;66(9):1450. Martin, Bendszus [corrected to Bendszus, Martin]
  • (PMID = 16476951.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Sughrue ME, Yang I, Rutkowski MJ, Aranda D, Parsa AT: Preservation of facial nerve function after resection of vestibular schwannoma. Br J Neurosurg; 2010 Dec;24(6):666-71
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  • [Title] Preservation of facial nerve function after resection of vestibular schwannoma.
  • OBJECTIVE: Most data regarding facial nerve function in patients undergoing microsurgical resection of vestibular schwannomas predominantly include series performed at a single institution.
  • In an effort to minimise individual surgeon or institutional bias, we performed an analysis of the published literature on facial nerve outcomes following microsurgical resection of vestibular schwannomas.
  • The objective of this study was to provide a comprehensive assessment of reported outcomes for facial nerve preservation after VS surgery.
  • MATERIALS AND METHODS: We identified a total of 296 studies involving over 25,000 patients that included outcome data for facial nerve function of vestibular schwannoma patients treated surgically.
  • Data regarding surgical approach, tumour size, patient age, and use of intra-operative monitoring were extracted and correlated with facial nerve function after surgery.
  • Patients with preoperative facial nerve dysfunction (House-Brackmann score 3 or higher) were excluded and 'facial nerve preservation' was defined as grade I or II House-Brackmann function at last follow-up visit.
  • Patients treated with the middle cranial fossa approach had a trend towards higher overall facial nerve preservation rate (85%), compared to the translabyrinthine approach (81%, p = 0.07) , and did statistically better than the retrosigmoid approach (78%, p < 0.0001).
  • Patients with an average tumour size <20 mm had significantly improved facial nerve preservation rates, compared to larger tumours (90% vs. 67%, p < 0.0001).
  • Patients under 65 years of age had a lower facial nerve preservation rate (71% vs. 84%, p < 0.001).
  • Finally, the use of intra-operative monitoring improved the facial nerve preservation rate (76% vs. 71%, p < 0.001).
  • CONCLUSION: Factors that appear to be associated with facial nerve preservation after microsurgical resection of a vestibular schwannoma include tumour size <20 mm, use of the middle fossa approach and use of neuromonitoring during surgery.
  • These data provide a summary assessment of the published literature regarding facial nerve preservation after microsurgical resection of vestibular schwannoma.
  • [MeSH-major] Facial Nerve / physiopathology. Facial Nerve Injuries / prevention & control. Neuroma, Acoustic / physiopathology. Radiation Injuries / prevention & control. Radiosurgery / methods


50. Behari S, Tyagi I, Banerji D, Kumar V, Jaiswal AK, Phadke RV, Jain VK: Postauricular, transpetrous, presigmoid approach for extensive skull base tumors in the petroclival region: the successes and the travails. Acta Neurochir (Wien); 2010 Oct;152(10):1633-45
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  • [Title] Postauricular, transpetrous, presigmoid approach for extensive skull base tumors in the petroclival region: the successes and the travails.
  • METHODS: The lesions (n = 14) included petroclival meningiomas [(n = 5), including three recurrent lesions], dumbbell lower cranial nerve schwannomas (n = 2), giant acoustic schwannomas (n = 2), recurrent giant trigeminal nerve schwannoma (n = 1), glomus jugulare (n = 3), and recurrent petrous aneurysmal bone cyst (n = 1).
  • Small tumor remnants were left attached to the brainstem (n = 3, petroclival meningioma), carotid canal and cavernous sinus (n = 1, glomus jugulare), and sigmoid sinus-jugular bulb (n = 1, recurrent trigeminal schwannoma).
  • Two patients with recurrent giant petroclival meningiomas died: one with lower cranial nerve paresis due to aspiration pneumonitis and the other with cerebrospinal fluid otorrhoea and secondary meningitis.
  • CONCLUSIONS: The approach facilitates direct tumor decompression and its retraction away from the brainstem without initially encountering the intracisternal cranial nerves and neuraxis.
  • It provides multiple corridors for excising extensive posterior fossa tumors.
  • [MeSH-minor] Glomus Jugulare Tumor / diagnosis. Glomus Jugulare Tumor / pathology. Glomus Jugulare Tumor / surgery. Humans. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / diagnosis. Meningioma / pathology. Meningioma / surgery. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / surgery. Retrospective Studies

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  • (PMID = 20556624.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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51. Morawski K, Telischi FF, Bohorquez J, Niemczyk K: Preventing hearing damage using topical dexamethasone during reversible cochlear ischemia: an animal model. Otol Neurotol; 2009 Sep;30(6):851-7
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  • BACKGROUND: Cochlear ischemia induced by internal auditory artery (IAA) compression/stretching is thought to cause postoperative sensory hearing loss after attempted hearing preservation removal of acoustic neuroma tumors.

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  • (PMID = 19638939.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / 2R 44 DC 04344-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 7S5I7G3JQL / Dexamethasone
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52. Hafstrom A, Fransson PA, Karlberg M, Magnusson M: Subjective visual tilt and lateral instability after vestibular deafferentation. Acta Otolaryngol; 2006 Dec;126(11):1176-81
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  • [Title] Subjective visual tilt and lateral instability after vestibular deafferentation.
  • CONCLUSION: Defective utricular function, reflected by deviation of the perceived visual horizontal or vertical, cannot by itself explain increased postural sway in the lateral direction for patients with unilateral vestibular deafferentation (uVD).
  • PATIENTS AND METHODS: The SVH-V was tested in 28 patients 6 months after translabyrinthine surgery for unilateral vestibular schwannoma, and correlated with posturography results.
  • [MeSH-major] Afferent Pathways / physiopathology. Dominance, Cerebral / physiology. Kinesthesis / physiology. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology. Postural Balance / physiology. Saccule and Utricle / physiopathology. Vestibular Nerve / physiopathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Meniere Disease / physiopathology. Middle Aged. Orientation / physiology. Otolithic Membrane / physiopathology. Retrospective Studies. Vestibular Function Tests. Visual Perception / physiology

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  • (PMID = 17050310.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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53. Bardakci F, Arslan S, Bardakci S, Binatli AO, Budak M: Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors. J Cancer Res Clin Oncol; 2008 Jan;134(1):109-14
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  • [Title] Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors.
  • The present study has investigated the association between SULT1A1 polymorphism and primary brain tumor incidence.
  • METHODS: SULT1A1 genotypes were successfully detected using the PCR-RFLP assay in 60 primary brain tumor patients and 156 hospital-based healthy control individuals with no history of cancer or precancerous disorder.
  • RESULTS: There was a significant difference in genotypes distribution (GG vs. GA + AA) between brain tumor patients (GG genotype frequency = 48.3%) and control population (GG genotype frequency = 65.4%; OR = 2.019, 95% CI = 1.103-3.695; P = 0.022).
  • In order to determine the association between SULT1A1 polymorphism and specific types of brain tumors, the patients were classified according to the type of brain tumors they suffer from: glial and non-glial.
  • Results of the statistical analyses of each group of patients in comparison with the control individuals showed a significant difference only between SULT1A1 polymorphism and non-glial brain tumors (OR = 2.615; 95% CI = 1.192-5.739; P = 0.014) but glial tumors (OR = 1.535; 95% CI = 0.688-3.425; P = 0.293).
  • When non-glial tumors were classified as meningiomal and others (pituitary adenoma, craniopharyngioma, acoustic neuroma and hemangioblastoma), statistical analysis showed that this significance is only due to the meningiomal tumors (OR = 3.238; CI = 1.205-8.704; P = 0.015).
  • We also estimated a reduced risk of brain tumor in non-smokers (OR = 1.700; CI = 0.800-3.615) in comparison to smokers (OR = 2.773; CI = 0.993-7.749), but this was not statistically significant.
  • CONCLUSION: Our findings have suggested that there was a significant association between brain tumor and SULT1A1*2 allele (A allele that is also known as His allele) and this allele is an important risk factor in the development of meningiomal brain tumors.
  • [MeSH-major] Arylsulfotransferase / genetics. Brain Neoplasms / genetics. Genetic Predisposition to Disease. Polymorphism, Genetic
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Alleles. Case-Control Studies. Child. Child, Preschool. Craniopharyngioma / enzymology. Craniopharyngioma / genetics. Craniopharyngioma / pathology. Female. Hemangioblastoma / enzymology. Hemangioblastoma / genetics. Hemangioblastoma / pathology. Humans. Infant. Male. Meningioma / enzymology. Meningioma / genetics. Meningioma / pathology. Middle Aged. Neuroma, Acoustic / enzymology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology. Pituitary Neoplasms / enzymology. Pituitary Neoplasms / genetics. Pituitary Neoplasms / pathology. Polymerase Chain Reaction. Polymorphism, Restriction Fragment Length. Prognosis. Risk Factors. Turkey / epidemiology

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  • (PMID = 17605044.001).
  • [ISSN] 1432-1335
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.8.2.1 / Arylsulfotransferase; EC 2.8.2.1 / SULT1A1 protein, human
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54. Fukuoka S, Takanashi M, Hojyo A, Konishi M, Tanaka C, Nakamura H: Gamma knife radiosurgery for vestibular schwannomas. Prog Neurol Surg; 2009;22:45-62
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  • [Title] Gamma knife radiosurgery for vestibular schwannomas.
  • The purpose of this study was to analyze tumor control and possible complications of gamma knife radiosurgery (GKRS) in patients with vestibular schwannomas using low marginal doses and conformal multiple shots to fit irregular tumor shapes.
  • The actuarial tumor control rates were 94% at 5 years and 92.4% at 8 years.
  • Larger tumors (p < 0.0001) and those in younger patients (p = 0.018) tended to recur significantly more often.
  • Fifty-six other patients not included in the long-term evaluation consecutively underwent caloric testing and static stabilometry as well as neurological examinations to evaluate vestibular function in detail, both before and after GKRS.
  • The results revealed 90% of the patients to have already developed vestibular dysfunction prior to the treatment despite reported symptoms of dizziness.
  • GKRS did not significantly affect vestibular function.
  • Hydrocephalus was recognized in 5.3% of all patients, and tended to occur in cases with larger tumors (p = 0.0024).
  • GKRS provides a safe and effective therapy for small to medium-sized tumors.
  • However, indications for larger tumors must be carefully considered, as they are more difficult to control and liable to produce ataxia due to transient expansion.
  • [MeSH-major] Hearing. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve / physiology. Female. Follow-Up Studies. Humans. Hydrocephalus / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / diagnosis. Radiation Dosage. Tomography, Emission-Computed, Single-Photon. Treatment Outcome. Trigeminal Nerve / physiology. Vestibular Nerve / physiology. Young Adult

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  • (PMID = 18948719.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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55. Sade B, Mohr G, Dufour JJ: Vascular complications of vestibular schwannoma surgery: a comparison of the suboccipital retrosigmoid and translabyrinthine approaches. J Neurosurg; 2006 Aug;105(2):200-4
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  • [Title] Vascular complications of vestibular schwannoma surgery: a comparison of the suboccipital retrosigmoid and translabyrinthine approaches.
  • OBJECT: Vascular complications of the surgery for vestibular schwannomas (VSs) can have devastating consequences; however, there is scant literature on the systematic analysis of the different types of complications.
  • [MeSH-major] Cerebellar Diseases / etiology. Cerebral Hemorrhage / etiology. Cerebral Infarction / etiology. Craniotomy / methods. Hematoma, Epidural, Cranial / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / etiology


56. Lee TX, Packer MD, Huang J, Akhmametyeva EM, Kulp SK, Chen CS, Giovannini M, Jacob A, Welling DB, Chang LS: Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. Eur J Cancer; 2009 Jun;45(9):1709-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.
  • BACKGROUND: Vestibular schwannomas (VS) frequently express high levels of activated AKT.
  • Small-molecule inhibitors of AKT signalling may have therapeutic potential in suppressing the growth of benign VS and malignant schwannomas.
  • METHOD: Primary VS and Schwann cells, human malignant schwannoma HMS-97 cells and mouse Nf2(-/-) Schwann cells and schwannoma cells were prepared to investigate the growth inhibitory and anti-tumour activities of OSU-03012, a celecoxib-derived small-molecule inhibitor of phosphoinositide-dependent kinase-1.
  • Cell proliferation assays, apoptosis, Western blot, in vivo xenograft analysis using SCID mice and immunohistochemistry were performed.
  • RESULTS: OSU-03012 inhibited cell proliferation more effectively in both VS and HMS-97 cells than in normal human Schwann cells.
  • The IC5) of OSU-03012 at 48h was approximately 3.1 microM for VS cells and 2.6 microM for HMS-97 cells, compared with the IC(50) of greater than 12 microM for human Schwann cells.
  • Similarly, mouse Nf2(-/-) schwannoma and Nf2(-/-) Schwann cells were more sensitive to growth inhibition by OSU-03012 than wild-type mouse Schwann cells and mouse schwannoma cells established from transgenic mice carrying the NF2 promoter-driven SV40 T-antigen gene.
  • Like VS cells, malignant schwannoma HMS-97 cells expressed high levels of activated AKT.
  • In vivo xenograft analysis showed that OSU-03012 was well tolerated and inhibited the growth of HMS-97 schwannoma xenografts by 55% after 9 weeks of oral treatment.
  • CONCLUSION: OSU-03012 is a potential chemotherapeutic agent for VS and malignant schwannomas.

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  • (PMID = 19359162.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC005985-04; United States / NIDCD NIH HHS / DC / R01 DC005985; United States / NIDCD NIH HHS / DC / R01 DC005985-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / OSU 03012; 0 / Protein Kinase Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.11.2 / pyruvate dehydrogenase (acetyl-transferring) kinase
  • [Other-IDs] NLM/ NIHMS103963; NLM/ PMC2692816
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57. Aihara N, Murakami S, Watanabe N, Takahashi M, Inagaki A, Tanikawa M, Yamada K: Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery. Skull Base; 2009 Sep;19(5):325-32
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery.
  • We developed a cochlear nerve action potential (CNAP) monitoring technique using a microdissector and compared the results of CNAP and auditory brainstem response (ABR) monitoring.
  • Thirty-six patients underwent vestibular schwannoma resection via the retrosigmoid approach to preserve hearing.
  • We used the microdissector as an intracranial electrode for CNAP monitoring.
  • At the completion of the tumor resection, the triphasic waveform was observed in 11 patients and the biphasic waveform was observed in 11 patients.

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  • (PMID = 20190942.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765700
  • [Keywords] NOTNLM ; auditory brainstem response / cochlear nerve action potential / microdissector / vestibular schwannoma
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58. Peñarrocha-Diago M, Mora-Escribano E, Bagán JV, Peñarrocha-Diago M: Neoplastic trigeminal neuropathy: presentation of 7 cases. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E106-11
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  • We present 7 cases of trigeminal neuropathy secondary to tumors: in four cases there were antecedents of systemic neoplastic disease, while in the remaining three cases neuropathy was the first manifestation of the tumor.
  • The lesion was located in the mandible in three cases, in the region of the skull base in one patient, and in the brainstem and brain in one case each.
  • Recovery was only recorded in one patient in whom the symptoms were seen to disappear after acoustic nerve neurinoma resection.
  • The lesions underlying neoplastic trigeminal neuropathy can be located at any point along the trajectory of the trigeminal nerve, and their prognosis is very poor.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / diagnosis. Trigeminal Nerve Diseases / diagnosis. Trigeminal Nerve Diseases / etiology

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  • (PMID = 16505784.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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59. Hardell L, Mild KH: Mobile phone use and acoustic neuromas. Epidemiology; 2005 May;16(3):415; author reply 417-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mobile phone use and acoustic neuromas.
  • [MeSH-major] Cell Phones. Neuroma, Acoustic / etiology

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  • [CommentOn] Epidemiology. 2004 Nov;15(6):653-9 [15475713.001]
  • (PMID = 15824564.001).
  • [ISSN] 1044-3983
  • [Journal-full-title] Epidemiology (Cambridge, Mass.)
  • [ISO-abbreviation] Epidemiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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60. Ramsden R, Khwaja S, Green K, O'Driscoll M, Mawman D: Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant? Otol Neurotol; 2005 Mar;26(2):261-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma in the only hearing ear: cochlear implant or auditory brainstem implant?
  • OBJECTIVE: To explore the dilemma faced by neurotologists confronted with the patient who develops a vestibular schwannoma in the only hearing ear, the other having been deaf from birth, and to consider the choice between auditory rehabilitation using a cochlear implant (CI) on the congenitally deaf side and an auditory brainstem implant (ABI) on the tumor side.
  • STUDY DESIGN: A record review of two patients born deaf in one ear and who developed a vestibular schwannoma in the contra lateral ear, who then received a CI in the congenitally deaf ear.
  • SETTING: Tertiary referral center with special experience in vestibular schwannoma surgery, neurofibromatosis type 2 management, and cochlear implantation.
  • In these circumstances, the authors advocate the insertion of an ABI at the time of tumor removal, retaining the option of CI in the congenitally deaf ear in the event of a poor outcome with the ABI.
  • [MeSH-major] Auditory Brain Stem Implantation. Cochlear Implantation. Deafness / congenital. Hearing Loss, Bilateral / rehabilitation. Neuroma, Acoustic / surgery. Postoperative Complications / rehabilitation

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  • (PMID = 15793416.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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61. Piccirillo E, Hiraumi H, Hamada M, Russo A, De Stefano A, Sanna M: Intraoperative cochlear nerve monitoring in vestibular schwannoma surgery--does it really affect hearing outcome? Audiol Neurootol; 2008;13(1):58-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative cochlear nerve monitoring in vestibular schwannoma surgery--does it really affect hearing outcome?
  • OBJECTIVE: The objective of this study was to examine the usefulness of intraoperative cochlear nerve monitoring (ICNM) in the preservation of normal and social hearing in vestibular schwannoma (VS) removal.
  • Among these, 99 patients with preoperative normal and social hearing (class A and B in the modified Sanna classification) and with a small tumor <1.5 cm in size were included in the analysis.
  • [MeSH-major] Hearing Loss / prevention & control. Monitoring, Intraoperative. Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control
  • [MeSH-minor] Action Potentials. Adult. Aged. Cochlear Nerve / physiology. Cranial Fossa, Middle / surgery. Evoked Potentials, Auditory, Brain Stem. Female. Hearing. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • [Copyright] Copyright (c) 2008 S. Karger AG, Basel.
  • (PMID = 17890858.001).
  • [ISSN] 1421-9700
  • [Journal-full-title] Audiology & neuro-otology
  • [ISO-abbreviation] Audiol. Neurootol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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62. Filho PA, Schankin CJ: Post-craniotomy headache after acoustic neuroma surgery. Cephalalgia; 2010 Apr;30(4):509-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Post-craniotomy headache after acoustic neuroma surgery.
  • [MeSH-major] Craniotomy / adverse effects. Headache Disorders / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / etiology


63. Magliulo G, D'Amico R, Celebrini A, Cuiuli G: Postoperative Ramsay-Hunt syndrome after acoustic neuroma resection. Viral reactivation. An Otorrinolaringol Ibero Am; 2005;32(3):253-9
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  • [Title] Postoperative Ramsay-Hunt syndrome after acoustic neuroma resection. Viral reactivation.
  • The aim of this paper is to present a patient suffering from acoustic neuroma and operated on with immediate postoperative hearing and facial function preservation who developed delayed Ramsay-Hunt syndrome.
  • [MeSH-major] Herpes Zoster Oticus / etiology. Herpes Zoster Oticus / virology. Neuroma, Acoustic / surgery. Postoperative Complications

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  • (PMID = 16001695.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antiviral Agents; X4HES1O11F / Acyclovir
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64. Bahri Zouari I, Ghariani M, Chtourou I, Makni S, Boudawara T: [A rare pigmented tumor of soft tissues]. Ann Pathol; 2006 Apr;26(2):143-4
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  • [Title] [A rare pigmented tumor of soft tissues].
  • [MeSH-major] Neuroma, Acoustic / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16791130.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 4.2.1.11 / Phosphopyruvate Hydratase
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65. Rosenvinge L, Johansen EC: [Schwannoma of the facial nerve--a rare disease, the choice of diagnostic imaging is very important]. Ugeskr Laeger; 2005 Apr 4;167(14):1530-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Schwannoma of the facial nerve--a rare disease, the choice of diagnostic imaging is very important].
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Facial Nerve Diseases / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Neuroma, Acoustic / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 15887751.001).
  • [ISSN] 0041-5782
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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66. Kutz JW, Barnett SL, Hatanpaa KJ, Mendelsohn DB: Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor. Skull Base; 2009 Nov;19(6):443-6
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  • [Title] Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor.
  • Vestibular schwannomas account for ~;80% of cerebellopontine angle (CPA) tumors, with meningiomas being the second most common tumor of the CPA.
  • The occurrence of both a schwannoma and a meningioma in the cerebellopontine angle is rare.
  • After obtaining Institutional Review Board approval, we present a case of a concurrent vestibular schwannoma and meningioma in the CPA mimicking a single tumor.

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  • (PMID = 20436847.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793893
  • [Keywords] NOTNLM ; Acoustic neuroma / cerebellopontine angle / meningioma / vestibular schwannoma
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67. Wanibuchi M, Fukushima T, McElveen JT Jr, Friedman AH: Hearing preservation in surgery for large vestibular schwannomas. J Neurosurg; 2009 Oct;111(4):845-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation in surgery for large vestibular schwannomas.
  • OBJECT: Hearing preservation remains a challenging problem in vestibular schwannoma (VS) surgery.
  • The ability to preserve hearing in patients with large tumors is subject to particular difficulty.
  • The tumors were classified as moderately large (21-30 mm based on the largest extrameatal diameter), large (31-40 mm), and giant (>or= 41 mm) according to the international criteria.
  • RESULTS: Forty-one tumors (75.9%) were totally removed and 13 (24.1%) had near-total removal.
  • In addition, according to the analysis based on the tumor size, 20 (52.6%) of 38 patients with moderately large tumors retained their hearing, as did 5 (50.0%) of 10 patients with large tumors and 4 (66.7%) of 6 patients with giant tumors.
  • Complications included 2 cases of bacterial meningitis that were cured by intravenous injection of antibiotics, 3 cases of subcutaneous CSF leakage that resolved without any surgical repair, and 1 case of temporary abducent nerve palsy.
  • CONCLUSIONS: The results indicate that successful hearing preservation surgery in large VSs is possible with meticulous technique and attention to adhesions between the tumor and the cochlear nerves.
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adult. Aged. Cochlear Nerve / pathology. Female. Humans. Male. Middle Aged. Retrospective Studies. Tissue Adhesions / pathology. Treatment Outcome

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  • (PMID = 19344218.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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68. Woodson EA, Dempewolf RD, Gubbels SP, Porter AT, Oleson JJ, Hansen MR, Gantz BJ: Long-term hearing preservation after microsurgical excision of vestibular schwannoma. Otol Neurotol; 2010 Sep;31(7):1144-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term hearing preservation after microsurgical excision of vestibular schwannoma.
  • OBJECTIVE: To examine long-term hearing outcomes after microsurgical excision of vestibular schwannoma (VS).
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Hearing. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 20679955.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / P50 DC000242; United States / NIDCD NIH HHS / DC / R01 DC009801; United States / NCRR NIH HHS / RR / UL1 RR025011
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS454674; NLM/ PMC3641783
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69. Lüdemann WO, Stieglitz LH, Gerganov V, Samii A, Samii M: Fat implant is superior to muscle implant in vestibular schwannoma surgery for the prevention of cerebrospinal fluid fistulae. Neurosurgery; 2008 Jul;63(1 Suppl 1):ONS38-42; discussion 42-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat implant is superior to muscle implant in vestibular schwannoma surgery for the prevention of cerebrospinal fluid fistulae.
  • OBJECTIVE: Meticulous sealing of opened air cells in the petrous bone is necessary for the prevention of cerebrospinal fluid (CSF) fistulae after vestibular schwannoma surgery.
  • Analysis was performed regarding the incidence of postoperative CSF fistulae and correlation with the patient's sex and tumor grade.
  • There was an inverse correlation with tumor grade.
  • Patients with smaller tumors seemed to have a higher rate of CSF leakage than those with large tumors without hydrocephalus.
  • Only large tumors with severe dislocation of the brainstem causing hydrocephalus showed a higher incidence of CSF leaks.
  • CONCLUSION: Fat implantation is superior to muscle implantation for the prevention of CSF leakage after vestibular schwannoma surgery and should, therefore, be used for the sealing of opened air cells in cranial base surgery.
  • [MeSH-major] Bioprosthesis. Cerebrospinal Fluid Rhinorrhea / prevention & control. Muscle, Skeletal / transplantation. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Subcutaneous Fat / transplantation

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  • (PMID = 18728602.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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70. Lahkola A, Tokola K, Auvinen A: Meta-analysis of mobile phone use and intracranial tumors. Scand J Work Environ Health; 2006 Jun;32(3):171-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meta-analysis of mobile phone use and intracranial tumors.
  • OBJECTIVES: A summary of epidemiologic evidence regarding the effect of mobile phone use on intracranial tumor risk was obtained by means of a meta-analysis.
  • METHODS: Reports of published studies on mobile phone use and intracranial tumors were sought.
  • A pooled estimate was calculated for all intracranial tumors combined and also separately for different histological tumor types.
  • Separate analyses were conducted also based on the tumor location and type of mobile telephone network (NMT or GSM).
  • RESULTS: Twelve studies with 2780 cases gave a pooled odds ratio (OR) of 0.98 [95% confidence interval (95% CI) 0.83-1.16] for all intracranial tumors related to mobile phone use.
  • For gliomas, the pooled OR was 0.96 (95% CI 0.78-1.18), for meningiomas it was 0.87 (95% CI 0.72-1.05), and for acoustic neuromas it was 1.07 (95% CI 0.89-1.30).
  • Little indication was found for increased risks of analogue or digital phone use or temporal or occipital tumors.
  • CONCLUSIONS: The totality of evidence does not indicate a substantially increased risk of intracranial tumors from mobile phone use for a period of at least 5 years.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones

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  • [CommentIn] Scand J Work Environ Health. 2006 Jun;32(3):169-70 [16804617.001]
  • (PMID = 16804618.001).
  • [ISSN] 0355-3140
  • [Journal-full-title] Scandinavian journal of work, environment & health
  • [ISO-abbreviation] Scand J Work Environ Health
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Finland
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71. Coez A, Zilbovicius M, Ferrary E, Bouccara D, Mosnier I, Ambert-Dahan E, Kalamarides M, Bizaguet E, Syrota A, Samson Y, Sterkers O: Processing of voices in deafness rehabilitation by auditory brainstem implant. Neuroimage; 2009 Oct 1;47(4):1792-6
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  • Profound acquired deafness by post-meningitis ossified cochlea and by bilateral vestibular schwannoma in neurofibromatosis type 2 patients are two indications for auditory brainstem implantation (ABI).
  • ABI allowed the transmission of sound stimuli to temporal brain regions but lacked transmitting the specific cues of the human voice to the TVA.
  • Moreover, among groups, during silent condition, brain visual regions showed higher rCBF in ABI group, although temporal brain regions had higher rCBF in the controls group.
  • [MeSH-major] Auditory Brain Stem Implantation / instrumentation. Auditory Cortex / physiology. Auditory Perception. Brain Mapping / methods. Deafness / physiopathology. Deafness / rehabilitation. Evoked Potentials, Auditory


72. Hol MK, Bosman AJ, Snik AF, Mylanus EA, Cremers CW: Bone-anchored hearing aids in unilateral inner ear deafness: an evaluation of audiometric and patient outcome measurements. Otol Neurotol; 2005 Sep;26(5):999-1006
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  • There were 19 patients with a history of acoustic neuroma surgery and 11 patients with unilateral inner ear deafness due to other causes; 1 patient was excluded.

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  • [ErratumIn] Otol Neurotol. 2006 Jan;27(1):130
  • (PMID = 16151349.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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73. Ciric I, Zhao JC, Rosenblatt S, Wiet R, O'Shaughnessy B: Suboccipital retrosigmoid approach for removal of vestibular schwannomas: facial nerve function and hearing preservation. Neurosurgery; 2005 Mar;56(3):560-70; discussion 560-70
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  • [Title] Suboccipital retrosigmoid approach for removal of vestibular schwannomas: facial nerve function and hearing preservation.
  • In this report, we discuss the pertinent bony, arachnoid, and neurovascular anatomy of vestibular schwannomas that has an impact on the surgical technique for removal of these tumors, with the goal of facial nerve and hearing preservation.
  • The surgical technique is described in detail starting with anesthesia, positioning, and neurophysiological monitoring and continuing with the exposure, technical nuances of tumor removal, hemostasis, and closure.
  • [MeSH-major] Facial Nerve Injuries / prevention & control. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control
  • [MeSH-minor] Anesthesia, General. Arachnoid / anatomy & histology. Cochlear Nerve / anatomy & histology. Dura Mater / surgery. Electromyography. Endolymphatic Duct / anatomy & histology. Evoked Potentials, Auditory, Brain Stem. Facial Nerve / anatomy & histology. Humans. Mastoid / anatomy & histology. Monitoring, Intraoperative. Neurosurgical Procedures / methods. Prognosis. Semicircular Canals / anatomy & histology

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  • (PMID = 15730582.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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74. Wuertenberger CJ, Rosahl SK: Vertigo and tinnitus caused by vascular compression of the vestibulocochlear nerve, not intracanalicular vestibular schwannoma: review and case presentation. Skull Base; 2009 Nov;19(6):417-24
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  • [Title] Vertigo and tinnitus caused by vascular compression of the vestibulocochlear nerve, not intracanalicular vestibular schwannoma: review and case presentation.
  • Microvascular compression of the vestibulocochlear nerve is known to cause disabling tinnitus and vertigo.
  • The authors add the case of a 46-year-old man with venous compression of the vestibulocochlear nerve inside the internal auditory canal (IAC).
  • Magnetic resonance images showed a small, contrast-enhancing lesion in the fundus of the right IAC, which was suspicious for vestibular schwannoma.
  • During surgical exploration, a large venous loop was found extending into the IAC and compressing the vestibulocochlear nerve.
  • The presumed vestibular schwannoma at the cochlear fossa was left in situ.
  • On follow-up, there has been no growth of the contrast-enhancing lesion in the IAC for 3 years so far.Disabling vertigo can also be caused by venous microvascular compression of the vestibulocochlear nerve inside the IAC and may be treated successfully by microvascular decompression.
  • A sensitive, conservative approach to lesions in the fundus may be justified in the presence of an additional, more prominent pathology that causes compression of the vestibulocochlear nerve.

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  • [Cites] Neurochirurgia (Stuttg). 1977 Sep;20(5):145-54 [198692.001]
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  • (PMID = 20436843.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2793889
  • [Keywords] NOTNLM ; Acoustic neuroma / microvascular decompression / tinnitus / vertigo / vestibular schwannoma / vestibulocochlear nerve
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75. Otto M, von Mühlendahl KE: Electromagnetic fields (EMF): do they play a role in children's environmental health (CEH)? Int J Hyg Environ Health; 2007 Oct;210(5):635-44
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  • Final results of the INTERPHONE study on the risk of brain tumours, acoustic neurinoma and parotid gland tumours associated with the use of mobile phones will be soon available.
  • [MeSH-minor] Cell Phones. Child. Humans. Leukemia, Radiation-Induced / etiology. Microwaves


76. Isaacson B, Telian SA, El-Kashlan HK: Facial nerve outcomes in middle cranial fossa vs translabyrinthine approaches. Otolaryngol Head Neck Surg; 2005 Dec;133(6):906-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Facial nerve outcomes in middle cranial fossa vs translabyrinthine approaches.
  • OBJECTIVE: To compare the final facial nerve outcomes between middle cranial fossa (MCF) vs translabyrinthine (TL) resection of size-matched vestibular schwannomas.
  • All patients who underwent resection utilizing either MCF or TL approaches with tumors 18 mm or smaller and complete data were included in the analysis.
  • One-week-postoperative and final facial nerve examinations were compared in the two surgical groups.
  • Patients were separately analyzed in subgroups: tumors smaller than 10 mm and those that were between 10 and 18 mm.
  • RESULTS: The tumor size range for the MCF group was 3-18 mm while it was 4-18 mm for the TL group.
  • No statistically significant difference was found in facial nerve outcomes between the two surgical groups, at the first postoperative visit week and at last follow-up.
  • CONCLUSION: Facial nerve outcomes are similar using TL and MCF approaches for resection of vestibular schwannomas up to 18 mm in size.
  • SIGNIFICANCE: Patients undergoing the MCF approach for hearing preservation can be counseled that there is no increased risk of permanent facial nerve weakness, compared to the TL approach.
  • [MeSH-major] Cranial Fossa, Middle / surgery. Ear, Inner / surgery. Facial Nerve / physiopathology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods

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  • (PMID = 16360512.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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77. Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD: DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol; 2010 Jan;12(1):37-48
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  • [Title] DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
  • Although the etiology of primary brain tumors is largely unknown, prior studies suggest that DNA repair polymorphisms may influence risk of glioma.
  • Altered DNA repair is also likely to affect the risk of meningioma and acoustic neuroma, but these tumors have not been well studied.
  • We estimated the risk of glioma (n = 362), meningioma (n = 134), and acoustic neuroma (n = 69) in non-Hispanic whites with respect to 36 single nucleotide polymorphisms from 26 genes involved in DNA repair in a hospital-based, case-control study conducted by the National Cancer Institute.
  • Risk of acoustic neuroma was increased for the ERCC2 rs1799793 (P(trend) .03) and ERCC5 rs17655 (P(trend) .05) variants and decreased for the PARP1 rs1136410 (P(trend) .03).
  • Our results suggest that common DNA repair variants may affect the risk of adult brain tumors, especially meningioma.


78. Mathai KI, Sengupta SK, Shashivadhanan, Khanna V, Sudumbrekar SM, Sahoo PK: Hearing Preservation in a Case of Acoustic Schwannoma. Med J Armed Forces India; 2009 Jul;65(3):290-1
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  • [Title] Hearing Preservation in a Case of Acoustic Schwannoma.

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  • (PMID = 27408274.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921402
  • [Keywords] NOTNLM ; Acoustic schwannoma / Hearing conservation
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79. Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM: Radiation therapy and hearing loss. Int J Radiat Oncol Biol Phys; 2010 Mar 1;76(3 Suppl):S50-7
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  • A review of literature on the development of sensorineural hearing loss after high-dose radiation therapy for head-and-neck tumors and stereotactic radiosurgery or fractionated stereotactic radiotherapy for the treatment of vestibular schwannoma is presented.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20171518.001).
  • [ISSN] 1879-355X
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA129182; None / None / / R01 CA129182-01A2; United States / NCI NIH HHS / CA / R01 CA129182-01A2
  • [Publication-type] Journal Article; Meta-Analysis; Review
  • [Publication-country] United States
  • [Number-of-references] 41
  • [Other-IDs] NLM/ NIHMS186726; NLM/ PMC3319461
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80. Ushio M, Iwasaki S, Chihara Y, Kawahara N, Morita A, Saito N, Murofushi T: Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response? Acta Otolaryngol; 2009 Oct;129(10):1095-100
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response?
  • CONCLUSIONS: The results of the caloric test, vestibular evoked myogenic potential (VEMP), and auditory brainstem response (ABR) in patients with vestibular schwannoma (VS) did not show clear correlation with the nerve origin of the tumor but with tumor size.
  • When we focused on patients with VS within the internal acoustic canal (IAC), neither the nerve origin of the tumor nor the tumor size showed clear correlation with the results of these tests.
  • OBJECTIVES: This study examined the correlation of the nerve origin of VS, superior or inferior vestibular nerve, with the results of function tests.
  • Tumor size was measured with preoperative MRI.
  • RESULTS: The nerve origin of the tumor was identified in 63 of the 109 patients.
  • Mean tumor size in patients showing abnormal responses was larger than that in patients showing normal responses on each test.
  • [MeSH-major] Neuroma, Acoustic / etiology
  • [MeSH-minor] Adult. Aged. Caloric Tests. Evoked Potentials, Auditory, Brain Stem. Humans. Middle Aged. Vestibular Evoked Myogenic Potentials. Vestibular Nerve / pathology. Vestibular Nerve / physiopathology. Young Adult

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  • (PMID = 19034733.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
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81. Lobato-Polo J, Kondziolka D, Zorro O, Kano H, Flickinger JC, Lunsford LD: Gamma knife radiosurgery in younger patients with vestibular schwannomas. Neurosurgery; 2009 Aug;65(2):294-300; discussion 300-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery in younger patients with vestibular schwannomas.
  • OBJECTIVE: Management options for patients with vestibular schwannoma include observation, surgical resection, stereotactic radiosurgery (SRS), and stereotactic radiation therapy.
  • We studied tumor response and clinical outcomes after SRS in such patients.
  • METHODS: We reviewed long-term outcomes in 55 patients with vestibular schwannomas.
  • The median tumor volume was 1.7 mm.
  • The median tumor margin dose was 13.0 Gy (range, 11-20 Gy).
  • At the last assessment, facial and trigeminal nerve function was preserved in 98.2% and 96.4% of patients, respectively; the only facial deficit (House-Brackmann grade III) occurred in a patient who received a tumor dose of 20 Gy early in our experience (1988).
  • No patient developed a secondary radiation-related tumor.
  • CONCLUSION: Our experience indicates that GK SRS is an effective management strategy for younger patients with vestibular schwannoma, most of whom have no additional cranial nerve dysfunction.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / statistics & numerical data. Vestibular Nerve / surgery
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Cochlear Nerve / physiopathology. Cochlear Nerve / radiation effects. Facial Nerve / physiopathology. Facial Nerve / radiation effects. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Female. Hearing Loss, Sensorineural / epidemiology. Hearing Loss, Sensorineural / prevention & control. Humans. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Radiation Dosage. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / physiopathology. Trigeminal Nerve / radiation effects. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / prevention & control. Young Adult

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  • (PMID = 19625908.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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82. Thomas BN, Flowers D, Caswell J, Robbé IJ: Mobile phone use and acoustic neuromas. Epidemiology; 2005 May;16(3):415-6; author reply 417-8
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  • [Title] Mobile phone use and acoustic neuromas.
  • [MeSH-major] Cell Phones. Neuroma, Acoustic / etiology

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  • [CommentOn] Epidemiology. 2004 Nov;15(6):653-9 [15475713.001]
  • (PMID = 15824563.001).
  • [ISSN] 1044-3983
  • [Journal-full-title] Epidemiology (Cambridge, Mass.)
  • [ISO-abbreviation] Epidemiology
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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83. Göksu N, Bayazit YA, Yilmaz M, Bayramoğlu I: Surgical treatment of peripheral vertigo and vertiginous diseases. ORL J Otorhinolaryngol Relat Spec; 2005;67(1):1-9
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  • The objective for the treatment of a vertiginous disease is to eliminate the underlying pathology either with maneuvers or drugs.
  • In vertiginous diseases, surgery is performed either to eliminate the underlying pathologic event or to create stability in the incoming vestibular signals.
  • It is not always possible to treat the underlying disease.
  • Selection of the approach depends on the type of vertiginous disease.
  • [MeSH-minor] Arachnoid Cysts / surgery. Cerebellum / physiopathology. Cochlea / surgery. Ear, Inner / surgery. Edema / physiopathology. Endolymphatic Sac / surgery. Gravitation. Humans. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Pons / physiopathology. Saccule and Utricle / surgery. Vestibular Nerve / surgery

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  • [Copyright] Copyright (c) 2005 S. Karger AG, Basel.
  • (PMID = 15637415.001).
  • [ISSN] 0301-1569
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 80
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84. Dispenza F, De Stefano A: Imaging of vestibular schwannoma with prevalent cystic component: cystic vestibular schwannoma. Otol Neurotol; 2009 Aug;30(5):681-2
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  • [Title] Imaging of vestibular schwannoma with prevalent cystic component: cystic vestibular schwannoma.
  • [MeSH-major] Arachnoid Cysts / pathology. Epidermal Cyst / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 18716565.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Luppino FS, Grooters E, de Bruïne FT, Zwinderman AH, van der Mey AG: Volumetrical measurements in vestibular schwannoma, the influence of slice thickness and patient's repositioning. Otol Neurotol; 2006 Oct;27(7):962-8
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  • [Title] Volumetrical measurements in vestibular schwannoma, the influence of slice thickness and patient's repositioning.
  • OBJECTIVE: Conservative treatment in vestibular schwannomas is mainly dependent on optimal tumor size determination.
  • Because of a relatively large systematic error in small tumors, sensitivity of growth detection is low.
  • CONCLUSION: The volumetrical gray shade method is the most accurate method to detect early tumor progression.
  • As tumor increase of at least 50% is needed to be able to speak of statistically significant tumor growth, the absence of radiologic progression does not mean that there is no tumor growth.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroma, Acoustic / pathology. Observer Variation

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  • (PMID = 17006347.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Validation Studies
  • [Publication-country] United States
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86. Hsu PW, Chang CN, Lee ST, Huang YC, Chen HC, Wang CC, Hsu YH, Tseng CK, Chen YL, Wei KC: Outcomes of 75 patients over 12 years treated for acoustic neuromas with linear accelerator-based radiosurgery. J Clin Neurosci; 2010 May;17(5):556-60
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  • [Title] Outcomes of 75 patients over 12 years treated for acoustic neuromas with linear accelerator-based radiosurgery.
  • The aim of this study was to investigate the efficacy of linear accelerator (LINAC)-based radiosurgery in the treatment of acoustic neuromas.
  • In this retrospective study, we enrolled 75 patients with non-neurofibromatosis type 2 acoustic neuromas who were followed-up for more than 5years.
  • The 75 patients were divided into 3 groups: patients with a newly diagnosed tumor; those with a residual tumor; and those with a recurrent tumor.
  • The overall tumor progression-free rate was 92%, and corresponding rates among those with newly diagnosed tumors was 100%, residual tumors was 84.4%, and recurrent tumors was 92.8% (p=0.028).
  • Lesion localization using CT scans correlated with a higher tendency for tumor progression than lesion localization using CT-MRI fusion images (15.6% versus 2.4%, respectively).
  • Residual tumors treated with radiosurgery have a higher progression rate, and careful lesion localization using CT-MRI image fusion is required.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Treatment Outcome

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  • (PMID = 20227884.001).
  • [ISSN] 1532-2653
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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87. Chen CC, Cheng PW, Tseng HM, Young YH: Posterior cranial fossa tumors in young adults. Laryngoscope; 2006 Sep;116(9):1678-81
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  • [Title] Posterior cranial fossa tumors in young adults.
  • OBJECTIVE/HYPOTHESIS: This retrospective study presents our experience on the posterior cranial fossa tumors in young adults during the past 15 years.
  • METHODS: From 1991 to 2005, 16 (0.8%) of 2,091 young adults (range, 16-29 years) with dizziness/vertigo, hearing loss, or tinnitus were diagnosed with posterior fossa tumor.
  • Diagnoses consisted of vestibular schwannoma and neurofibromatosis II in eight patients (50%), glial neoplasm (including astrocytoma, ependymoma, glioma) in four patients (25%), epidermoid cyst in three patients, and glomus jugulare tumor in one patient.
  • At study close, excluding one lost patient, three patients died as a result of recurrent or residual tumor at the primary site.
  • CONCLUSIONS: Unlike predominant medulloblastoma in children, the most frequent posterior fossa tumor in young adults is vestibular schwannoma and neurofibroma.
  • However, the second most frequent one in young adults is glial neoplasm as opposed to meningioma in adults.

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  • (PMID = 16955003.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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88. Rajaraman P, Schwartz BS, Rothman N, Yeager M, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD: Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults. Environ Health Perspect; 2005 Sep;113(9):1209-11
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  • [Title] Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults.
  • The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma.
  • In this study we examined whether the ALAD G177C polymorphism in the gene coding for ALAD is associated with risk of intracranial tumors of the brain and nervous system.
  • We use data from a case-control study with 782 incident brain tumor cases and 799 controls frequency matched on hospital, age, sex, race/ethnicity, and residential proximity to the hospital.
  • ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls).
  • No increased risk associated with the ALAD2 variant was observed for glioma or acoustic neuroma.
  • [MeSH-major] Brain Neoplasms / genetics. Genetic Predisposition to Disease. Meningioma / genetics. Porphobilinogen Synthase / genetics

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  • (PMID = 16140629.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 4.2.1.24 / Porphobilinogen Synthase
  • [Other-IDs] NLM/ PMC1280403
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89. Plotkin SR, Singh MA, O'Donnell CC, Harris GJ, McClatchey AI, Halpin C: Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy. Nat Clin Pract Oncol; 2008 Aug;5(8):487-91
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  • [Title] Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy.
  • INVESTIGATIONS: Medical and neurological examination, MRI scan of the brain and spinal cord, pure-tone audiometry, NU-6 monosyllabic word test with phoneme scoring, City University of New York topic-related sentences test, noise/voice test of minimal auditory capability battery.
  • DIAGNOSIS: Progressive neurofibromatosis-type-2-related vestibular schwannomas.
  • MANAGEMENT: Annual cranial MRI and audiology, surgical resection of right vestibular schwannoma, high-power behind-the-ear hearing aid, erlotinib therapy for progressive left vestibular schwannoma.
  • [MeSH-minor] Audiometry, Pure-Tone. Auditory Threshold. Combined Modality Therapy. Erlotinib Hydrochloride. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Protein Kinase Inhibitors / administration & dosage. Treatment Outcome. Vestibular Diseases / complications. Vestibular Diseases / drug therapy. Vestibular Diseases / surgery

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  • (PMID = 18560388.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
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90. Chu M, Wei LL, Li GZ, Lin YZ, Zhao SG: Bilateral acoustic neurinomas presenting as subarachnoid hemorrhage: case report. Chin Med J (Engl); 2007 Jan 5;120(1):83-4
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  • [Title] Bilateral acoustic neurinomas presenting as subarachnoid hemorrhage: case report.
  • [MeSH-major] Neuroma, Acoustic / complications. Subarachnoid Hemorrhage / etiology

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  • (PMID = 17254495.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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91. DiPatri AJ Jr, Pham M, Muro K: Late effects of neurosurgery. Cancer Treat Res; 2009;150:7-22
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  • [MeSH-major] Brain Neoplasms / surgery. Neurosurgical Procedures / adverse effects. Postoperative Complications / epidemiology
  • [MeSH-minor] Adult. Child. Cognition Disorders / etiology. Cranial Irradiation / adverse effects. Endocrine System Diseases / etiology. Growth Disorders / etiology. Humans. Mutism / etiology. Neoplasms, Second Primary / etiology. Neuroma, Acoustic / etiology. Radiosurgery / adverse effects. Seizures / etiology. Survivors

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  • (PMID = 19834659.001).
  • [ISSN] 0927-3042
  • [Journal-full-title] Cancer treatment and research
  • [ISO-abbreviation] Cancer Treat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 105
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92. Goutagny S, Bouccara D, Bozorg-Grayeli A, Sterkers O, Kalamarides M: [Neurofibromatosis type 2]. Rev Neurol (Paris); 2007 Sep;163(8-9):765-77
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  • [Transliterated title] La neurofibromatose de type 2.
  • INTRODUCTION: Neurofibromatosis 2 (NF2) is a rare autosomal dominant disease whose hallmark is the development of bilateral vestibular schwannomas.
  • STATE OF THE ART: Other features of NF2 include schwannomas, meningiomas, ependymomas, localized along the central nervous system, schwannomas of the peripheral nerves, cutaneous and ophthalmological manifestations.
  • NF2 can be diagnosed in patients without bilateral vestibular schwannoma with sets of diagnostic criteria.
  • Disease phenotype is variable among patients.
  • Main negative prognostic factors are a young age at onset of symptoms and a high number of tumors at diagnosis.
  • NF2 tumor suppressor gene encodes Merlin/Schwannomin, and is also involved in most sporadic schwannomas and meningiomas.
  • Some authors advocate an early proactive strategy against vestibular schwannoma in order to preserve hearing.
  • When a treatment is advisable, surgery remains the treatment of choice for tumors.
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / epidemiology. Ependymoma / genetics. Ependymoma / pathology. Female. Genes, Tumor Suppressor. Humans. Male. Middle Aged. Neurilemmoma / genetics. Neurilemmoma / pathology. Prognosis

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  • (PMID = 17878803.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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93. House WF, Shelton C: Middle fossa approach for acoustic tumor removal. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):279-88, vi
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  • [Title] Middle fossa approach for acoustic tumor removal. 1992.
  • The middle fossa approach is useful for the removal of small acoustic tumors when hearing preservation is possible.
  • This approach provides complete exposure of the contents of the internal auditory canal and positive facial nerve identification.
  • Because access to the posterior fossa is limited, the middle fossa approach is most appropriate for tumors with less than 5 mm extension into the cerebellopontine angle.
  • With the introduction of gadolinium-enhanced magnetic resonance imaging, very small acoustic tumors are diagonosed more frequently, and the middle fossa approach is well-suited for the removal of these tumors.
  • [MeSH-major] Craniotomy / history. Neuroma, Acoustic / history

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  • (PMID = 18534340.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] House WF; Shelton C
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94. Myrseth E, Pedersen PH, Møller P, Lund-Johansen M: Treatment of vestibular schwannomas. Why, when and how? Acta Neurochir (Wien); 2007;149(7):647-60; discussion 660
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  • [Title] Treatment of vestibular schwannomas. Why, when and how?
  • Sporadic vestibular schwannoma (VS) causes unilateral hearing loss, tinnitus, vertigo and unsteadiness.
  • The predominant clinical endpoints of VS treatment include tumour control, facial nerve function and hearing preservation.
  • [MeSH-major] Neuroma, Acoustic / surgery. Neurosurgical Procedures / standards. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Radiosurgery / standards. Vestibular Nerve / surgery
  • [MeSH-minor] Facial Nerve Injuries / prevention & control. Humans. Quality of Life. Risk Assessment. Vestibulocochlear Nerve Diseases / prevention & control

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  • (PMID = 17558460.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 144
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95. Mead MN: Strong signal for cell phone effects. Environ Health Perspect; 2008 Oct;116(10):A422
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  • [Title] Strong signal for cell phone effects.
  • [MeSH-major] Cell Phones
  • [MeSH-minor] Brain Neoplasms / epidemiology. Brain Neoplasms / etiology. Child. Glioma / epidemiology. Glioma / etiology. Humans. Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / etiology. United States / epidemiology

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  • (PMID = 18941554.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] News
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2569116
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96. Nichetti E, Pelosi A, Piccirillo E, Sanna M, Bettinardi O, Rovetto F: [Emotional aspects and quality of life of patients after acoustic neuroma surgery]. G Ital Med Lav Ergon; 2009 Jan-Mar;31(1 Suppl A):A52-7
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  • [Title] [Emotional aspects and quality of life of patients after acoustic neuroma surgery].
  • [Transliterated title] Aspetti emotivi e qualità della vita in pazienti operati di neurinoma del nervo acustico.
  • Acoustic neuromas are rare lesions arising in the internal auditory canal (IAC) and extending in the posterior cranial fossa.
  • METHODS: By using a questionnaires of Quality of Life aims to evaluate the impact that the disease and the surgical procedure have on this population.
  • SUBJECTS: We have evaluated a sample of 150 subjects one year after the surgical removal of a acoustic neuroma.
  • CONCLUSION: Psychological support to subjects after discharge from acoustic neuroma surgical removal should be tailored to improve quality of life and for a better management of anxiety.
  • [MeSH-major] Anxiety / etiology. Neuroma, Acoustic / psychology. Quality of Life / psychology

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  • (PMID = 19621539.001).
  • [ISSN] 1592-7830
  • [Journal-full-title] Giornale italiano di medicina del lavoro ed ergonomia
  • [ISO-abbreviation] G Ital Med Lav Ergon
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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97. Neema PK, Rao S, Manikandan S, Rathod RC: Complications of unrecognized urinary bladder distension. Anesth Analg; 2007 Jan;104(1):226-7
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  • [MeSH-major] Neuroma, Acoustic / surgery. Urinary Bladder Diseases / complications. Urinary Catheterization / adverse effects. Urinary Retention / etiology

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  • (PMID = 17179296.001).
  • [ISSN] 1526-7598
  • [Journal-full-title] Anesthesia and analgesia
  • [ISO-abbreviation] Anesth. Analg.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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98. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102 Suppl:111-3
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  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> 3 cm in diameter).
  • Facial and cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.
  • [MeSH-major] Facial Nerve / physiology. Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cochlear Nerve / physiopathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Microsurgery / instrumentation. Middle Aged. Neoplasm Recurrence, Local. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / surgery. Radiation Dosage. Time Factors

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  • (PMID = 15662791.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Clark JJ, Provenzano M, Diggelmann HR, Xu N, Hansen SS, Hansen MR: The ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary study. Otol Neurotol; 2008 Sep;29(6):846-53
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  • [Title] The ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary study.
  • OBJECTIVE: To analyze the ability of ErbB inhibitors to reduce the growth of vestibular schwannoma (VS) xenografts.
  • METHODS: Vestibular schwannoma xenografts were established in the interscapular fat pad in nude mice for 4 weeks.
  • Tumor growth was monitored by magnetic resonance imaging during the treatment period.
  • Cell death was analyzed by terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling of fragmented DNA.
  • RESULTS: Tumors can be distinguished with T2-weighted magnetic resonance imaging sequences.
  • Control tumors demonstrated slight growth during the 12-week treatment period.
  • CONCLUSION: In this preliminary study, the ErbB inhibitors trastuzumab and erlotinib decreased growth of VS xenografts in nude mice, raising the possibility of using ErbB inhibitors in the management of patients with schwannomas, particularly those with neurofibromatosis Type 2.

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  • (PMID = 18636037.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / K08 DC006211; United States / NIDCD NIH HHS / DC / K08 DC006211-01A1; United States / NIDCD NIH HHS / DC / KO8 DC006211
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; P188ANX8CK / Trastuzumab
  • [Other-IDs] NLM/ NIHMS85822; NLM/ PMC2652856
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100. Kitahara T, Maekawa C, Kizawa K, Horii A, Doi K: Plasma vasopressin and V2 receptor in the endolymphatic sac in patients with delayed endolymphatic hydrops. Otol Neurotol; 2009 Sep;30(6):812-9
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  • Delayed endolymphatic hydrops (DEH) is an inner ear disease like Ménière's disease (MD) characterized by episodic vertigo in the setting of preexisting unilateral deafness that especially occurs in civilized people with a stressful lifestyle.
  • Its otopathologic finding was demonstrated to be inner ear endolymphatic hydrops through a temporal bone study in 1976, as in the case with MD in 1938.
  • Using the real-time polymerase chain reaction method with tissue samples obtained during surgery, we examined V2R mRNA expression in the endolymphatic sac in 6 patients with ipsilateral DEH, 9 patients with unilateral MD, and 6 control patients with acoustic neuroma.
  • RESULTS: Plasma vasopressin (1.5 times versus controls; unpaired t test, p = 0.140) and V2R mRNA expression in the endolymphatic sac (35.8 times versus controls; unpaired t test, p = 0.002) were higher in patients with DEH compared with those with acoustic neuroma.
  • [MeSH-minor] Adult. Blotting, Western. Data Interpretation, Statistical. Female. Humans. Male. Meniere Disease / complications. Middle Aged. Otologic Surgical Procedures. Prospective Studies. RNA / biosynthesis. RNA / genetics. Reverse Transcriptase Polymerase Chain Reaction. Vertigo / etiology

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  • (PMID = 19638944.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Vasopressin; 11000-17-2 / Vasopressins; 63231-63-0 / RNA
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