[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 1205
1. Patrinou A, Malindretos P, Koutroubas G, Anagnostou N, Argiraki E, Syrganis C: A rare retroperitoneal schwannoma in a patient with neurofibromatosis Type 2. NDT Plus; 2010 Jun;3(3):288-290

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare retroperitoneal schwannoma in a patient with neurofibromatosis Type 2.
  • Neurofibromatosis Type 2 (NF2) is a dominantly inherited tumour-prone disorder, characterized by the development of multiple schwannomas, meningiomas and ependymomas.
  • Vestibular schwannoma (VS) is the hallmark of NF2.
  • Retroperitoneal schwannomas are expected to occur in only 3% of cases.
  • We present the case of a large retroperitoneal schwannoma in a patient with NF2.
  • Brain, orbits, cervical, thoracic and lumbar MRI revealed bilateral VS, multiple meningiomas as well as multiple schwannomas and ependymomas in the cervical, thoracic and lumbar spine.
  • The retroperitoneal mass represents a schwannoma probably derived from an intercostal nerve.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Neurooncol. 2009 May;93(1):61-77 [19430883.001]
  • [Cites] Neurosurgery. 1996 May;38(5):880-5; discussion 885-6 [8727812.001]
  • [Cites] World J Gastroenterol. 2007 Nov 7;13(41):5521-4 [17907300.001]
  • [Cites] Curr Probl Cancer. 1981 Jul;6(1):1-47 [6266775.001]
  • [Cites] Orphanet J Rare Dis. 2009 Jun 19;4:16 [19545378.001]
  • [Cites] Tumori. 2007 May-Jun;93(3):312-5 [17679473.001]
  • [Cites] N Engl J Med. 2009 Jul 23;361(4):358-67 [19587327.001]
  • [Cites] J Neurosurg. 2003 Sep;99(3):480-3 [12959433.001]
  • [Cites] Arch Ophthalmol. 2006 Mar;124(3):379-85 [16534058.001]
  • (PMID = 28657039.001).
  • [ISSN] 1753-0784
  • [Journal-full-title] NDT plus
  • [ISO-abbreviation] NDT Plus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Keywords] NOTNLM ; meningioma / neurofibromatosis Type 2 / retroperitoneal / schwannoma
  •  go-up   go-down


2. Goel A, Muzumdar D: Bilateral acoustic neurinomas. Neurol India; 2006 Sep;54(3):329-30
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral acoustic neurinomas.
  • [MeSH-major] Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Brain Stem / pathology. Brain Stem / physiopathology. Brain Stem / surgery. Female. Humans. Magnetic Resonance Imaging / methods. Neurofibromatoses / complications. Neurosurgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16936415.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  •  go-up   go-down


3. Coca Pelaz A, Rodrigo JP, Llorente JL, Gómez JR, Suárez C: [Unusual clinical presentations of vestibular schwannomas]. Acta Otorrinolaringol Esp; 2008 Apr;59(4):187-9
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Unusual clinical presentations of vestibular schwannomas].
  • [Transliterated title] Formas clínicas inusuales de presentación de los neurinomas del acústico.
  • The aim of this study is evaluate the unusual ways of initial presentation of the vestibular schwannomas.
  • We performed a retrospective study of the patients who underwent resection of acoustic neuromas on our service, including for analysis only the cases which initial symptom was not the hearing loss.
  • Tumor size, localization, clinical presentation, and age of the patients were considered.
  • A significant group of patients did not present with the otological symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Cerebellopontine Angle / pathology. Hearing Loss / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18447978.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


Advertisement
4. Valentino V, Benassi M, Strigari L: Historia magistra vitae (Cic. De or. 2.36). The Prime Objective of Radiosurgery in Acoustic Neurinomas. Neuroradiol J; 2006 Nov 30;19(5):637-44
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Historia magistra vitae (Cic. De or. 2.36). The Prime Objective of Radiosurgery in Acoustic Neurinomas.
  • The central question of stereotaxic radiosurgery in acoustic neurinomas is how to pinpoint its main objective: is it a better alternative to neurosurgery or an option when surgery is unfeasible?
  • The conclusions that can be drawn to date from our own findings and from others in the literature are the following: radiosurgery can be used not only to prevent neurinoma growth and at the same time to preserve the patient's neurological conditions without the risk of complications, but it can also be counted on to provide a cure.
  • The expression coined by Lars Leksell regarded precisely the innovation he himself conceived in the 'closed skull operation', with reference to its use in cases of acoustic neurinoma as an alternative to traditional surgery.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 24351267.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


5. Coca A, Gómez JR, Llorente JL, Rodrigo JP, Núñez F, Sevilla MA, Suárez C: [Complications and sequelae in acoustic neuroma surgery]. Acta Otorrinolaringol Esp; 2007 Dec;58(10):470-5
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Complications and sequelae in acoustic neuroma surgery].
  • [Transliterated title] Complicaciones y secuelas en la cirugía de los neurinomas del acústico.
  • OBJECTIVE: To evaluate the complications and sequelae of acoustic neuroma surgery, according to tumour size.
  • PATIENTS AND METHOD: A retrospective analysis of 120 patients who underwent microsurgical resection of vestibular schwannomas between November 1994 and September 2006 was undertaken.
  • The facial nerve was anatomically and functionally preserved in 103 cases on long-term follow-up (85.4 %).
  • The cochlear nerve was functionally preserved (Gardner-Robertson class 1 and 2) in 54.4 % of the small tumours with useful preoperative hearing.
  • CONCLUSIONS: Despite the progress in the surgical treatment of acoustic neuromas, a considerable rate of complications and sequelae still remains.
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / statistics & numerical data. Postoperative Complications / epidemiology

  • Genetic Alliance. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - After Surgery.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18082077.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


6. Choy NL, Johnson N, Treleaven J, Jull G, Panizza B, Brown-Rothwell D: Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study. Aust J Physiother; 2006;52(3):211-6
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study.
  • QUESTION: Are there residual deficits in balance, mobility, and gaze stability after surgical removal of vestibular schwannoma?
  • PARTICIPANTS: Twelve people with a mean age of 52 years who had undergone surgical removal of vestibular schwannoma at least three months previously and had not undergone vestibular rehabilitation.
  • CONCLUSION: A prospective study is required to evaluate vestibular rehabilitation to ameliorate dizziness and to improve balance, mobility, and gaze stability for this clinical group.
  • [MeSH-major] Mobility Limitation. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Ocular Motility Disorders / etiology. Postural Balance. Sensation Disorders / etiology


7. Coca Pelaz A, Fernández Lisa C, Gómez JR, Rodrigo JP, Llorente JL, Suárez C: [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications]. Acta Otorrinolaringol Esp; 2008 May;59(5):223-7
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications].
  • [Transliterated title] Parálisis facial completa tras cirugía de neurinoma del acústico: evolución y complicaciones oftalmológicas asociadas.
  • OBJECTIVE: To evaluate the fraction of patients recovering to normal function after complete facial nerve paralysis secondary to acoustic neuroma surgery, and also to address the ophthalmologic complications associated with it and the therapeutic options.
  • MATERIAL AND METHOD: We performed a retrospective review of 30 cases operated on in our department for acoustic neuroma and who, despite anatomical preservation of the facial nerve, developed a complete post-operative facial nerve paralysis (grade VI of House-Brackmann [HB]).
  • RESULTS: Only 5 of the 30 cases studied (16.6 %) recovered to normal facial nerve function (HB grade I).
  • [MeSH-major] Cochlear Nerve / pathology. Cochlear Nerve / surgery. Corneal Ulcer / etiology. Facial Paralysis / etiology. Facial Paralysis / physiopathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Postoperative Complications
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Retrospective Studies

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18501157.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


8. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102(s_supplement):195-199

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm<sup>3</sup>.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28306432.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / radiosurgery / vestibular schwannoma
  •  go-up   go-down


9. Chung WY, Liu KD, Shiau CY, Wu HM, Wang LW, Guo WY, Ming-Tak Ho D, Hung-Chi Pan D: Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases. J Neurosurg; 2005 Jan;102(s_supplement):87-97

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases.
  • OBJECT: The authors conducted a study to determine the optimal radiation dose for vestibular schwannoma (VS) and to examine the histopathology in cases of treatment failure for better understanding of the effects of irradiation.
  • Seventy-two patients (37%) had undergone partial or total excision of their tumor prior to gamma knife surgery (GKS).
  • The mean tumor volume was 4.1 cm<sup>3</sup> (range 0.04-23.1 cm<sup>3</sup>).
  • Multiisocenter dose planning placed a prescription dose of 11 to 18.2 Gy on the 50 to 94% isodose located at the tumor margin.
  • At the latest MR imaging assessment decreased or stable tumor volume was demonstrated in 93.6% of the patients.
  • Uncontrolled tumor swelling was noted in five patients at 3.5, 17, 24, 33, and 62 months after GKS, respectively.
  • Histopathological examination of specimens in three cases (one at 62 months after GKS) revealed a long-lasting radiation effect on vessels inside the tumor.
  • A margin 12-Gy dose with homogeneous distribution is effective in preventing tumor progression, while posing no serious threat to normal cranial nerve function.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28306447.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / stereotaxy / vestibular schwannoma
  •  go-up   go-down


10. Myrseth E, Møller P, Wentzel-Larsen T, Goplen F, Lund-Johansen M: Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life. Neurosurgery; 2006 Jul 01;59(1):67-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28180608.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


11. Hasegawa T, Kida Y, Yoshimoto M, Koike J, Goto K: TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas. Neurosurgery; 2006 Jun 01;58(6):1119-1128

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28173267.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


12. Wowra B, Muacevic A, Jess-Hempen A, Hempel JM, Müller-Schunk S, Tonn JC: Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience. J Neurosurg; 2005 Jan;102(s_supplement):114-118
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience.
  • OBJECT: The purpose of the study was to define the therapeutic profile of outpatient gamma knife surgery (GKS) for vestibular schwannoma (VS) by using sequential tumor volumetry to quantify changes following treatment.
  • The actuarial 6-year tumor control rate after a single GKS treatment was 95%.
  • Tumor swelling was observed in 43 patients (38.7%).
  • Recurrence was significantly associated with NF2 (p < 0.003) and the reduced dose (p < 0.03) delivered to these tumors.
  • The incidence of facial nerve neuropathy was mainly determined by surgery prior to GKS (p < 0.0001).
  • Facial nerve radiation toxicity was mild and transient.
  • No permanent facial nerve toxicity was observed.
  • The risk of hearing loss was correlated with age and transient tumor swelling (p < 0.05) but not with dose parameters or NF2.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28306422.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / tumor volumetry / vestibular schwannoma
  •  go-up   go-down


13. van Eck AT, Horstmann GA: Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma. J Neurosurg; 2005 Jan;102(s_supplement):204-206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma.
  • OBJECT: Gamma knife surgery (GKS) for vestibular schwannoma is still associated with an additional hearing loss of approximately 30%.
  • The mean tumor volume was 2.28 cm<sup>3</sup>.
  • After a mean follow-up duration of 22 months, the magnetic resonance imaging-based tumor control rate was 87%.
  • One patient suffered transient facial nerve impairment.
  • CONCLUSIONS: Reducing the maximum dose to 20 Gy seems to be an effective treatment, which probably increases preservation of functional hearing without sacrificing the high tumor control rates achieved in radiosurgery.
  • Post-radiosurgery tumor swelling occurred in 25% of the cases and was not correlated with hearing deterioration.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28306452.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; acoustic neurinoma / gamma knife surgery / hearing preservation / tumor swelling / vestibular schwannoma
  •  go-up   go-down


14. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma. Neurosurgery; 2006 Jul 01;59(1):E206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28180621.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


15. Tlachacova D, Schmitt M, Novotny J Jr, Novotny J, Majali M, Liscak R: A comparison of the gamma knife model C and the Automatic Positioning System with Leksell model B. J Neurosurg; 2005 Jan;102(s_supplement):25-28
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data were analyzed in patients in whom the following diagnoses had been made: vestibular schwannoma, pituitary adenoma, meningioma, solitary metastasis, and other benign and malignant solitary tumors.
  • CONCLUSIONS: With the C model there was a better conformity for most treated targets, such as vestibular schwannomas (p = 0.005) and meningiomas (p = 0.015).

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28306471.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; conformity index / extracranial exposure / staff exposure / stereotactic radiosurgery
  •  go-up   go-down


16. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102(s_supplement):111-113

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28306427.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; facial function / gamma knife surgery / outcome / vestibular schwannoma
  •  go-up   go-down


17. Henzel M, Hamm K, Sitter H, Gross MW, Surber G, Kleinert G, Engenhart-Cabillic R: Comparison of stereotactic radiosurgery and fractionated stereotactic radiotherapy of acoustic neurinomas according to 3-D tumor volume shrinkage and quality of life. Strahlenther Onkol; 2009 Sep;185(9):567-73
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of stereotactic radiosurgery and fractionated stereotactic radiotherapy of acoustic neurinomas according to 3-D tumor volume shrinkage and quality of life.
  • This study aimed to evaluate three-dimensional (3-D) tumor volume (TV) shrinkage and to assess quality of life (QoL) after SRS/SRT.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiotherapy. Radiosurgery / methods

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19756422.001).
  • [ISSN] 1439-099X
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


18. Nabhan A, Ahlhelm F, Reith W, Steudel WI, Schwerdtfeger K: [Function of the facial nerve after operative treatment of acoustic neurinomas. Influence of intraoperative monitoring]. Nervenarzt; 2005 Feb;76(2):170-4
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Function of the facial nerve after operative treatment of acoustic neurinomas. Influence of intraoperative monitoring].
  • The aim of this study was to evaluate the influence of intraoperative monitoring on the function of the facial nerve after surgical treatment of acoustic neurinomas, classified according to the grading system of Stennert.
  • Despite structural preservation of the facial nerve, postoperative deterioration of its function was observed which consecutively improved postoperatively.
  • For better understanding of the role of intraoperative monitoring, we investigated the outcome of patients with acoustic neurinomas who underwent surgery over the following 6 months postoperatively.
  • We could show that intraoperative monitoring of the facial nerve was a significant factor for better postoperative function in patients undergoing microsurgical excision of neurinomas (P=0.001) .
  • [MeSH-major] Facial Nerve Injuries / prevention & control. Facial Paralysis / prevention & control. Microsurgery / adverse effects. Monitoring, Intraoperative / methods. Neuroma, Acoustic / surgery. Recovery of Function
  • [MeSH-minor] Facial Nerve. Humans. Male. Middle Aged. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15257437.001).
  • [ISSN] 0028-2804
  • [Journal-full-title] Der Nervenarzt
  • [ISO-abbreviation] Nervenarzt
  • [Language] ger
  • [Publication-type] Clinical Trial; Controlled Clinical Trial; English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


19. Machinis TG, Fountas KN, Dimopoulos V, Robinson JS: History of acoustic neurinoma surgery. Neurosurg Focus; 2005 Apr 15;18(4):e9
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] History of acoustic neurinoma surgery.
  • The purpose of this article is to provide insight into the development of surgery for acoustic neurinomas throughout the years.
  • The advances in surgical techniques from the very first operations for acoustic tumors at the end of the 19th century until today are described, with special emphasis on the technological and diagnostic milestones that preceded each step of this development.
  • [MeSH-major] Neuroma, Acoustic / history. Neuroma, Acoustic / surgery. Neurosurgery / history. Neurosurgical Procedures / history. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Cranial Fossa, Posterior / pathology. Cranial Fossa, Posterior / surgery. Facial Nerve Injuries / prevention & control. History, 19th Century. History, 20th Century. Humans. Intraoperative Complications / prevention & control. Microsurgery / history. Microsurgery / methods. Postoperative Complications / prevention & control. Radiosurgery / history. Radiosurgery / methods. Temporal Bone / pathology. Temporal Bone / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15844872.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
  •  go-up   go-down


20. Chu M, Wei LL, Li GZ, Lin YZ, Zhao SG: Bilateral acoustic neurinomas presenting as subarachnoid hemorrhage: case report. Chin Med J (Engl); 2007 Jan 5;120(1):83-4
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral acoustic neurinomas presenting as subarachnoid hemorrhage: case report.
  • [MeSH-major] Neuroma, Acoustic / complications. Subarachnoid Hemorrhage / etiology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17254495.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  •  go-up   go-down


21. Nikonova NG, Kapitanov DN, Golanov AV, Zolotova SV: [Current concepts of diagnosis and treatment of acoustic neurinomas]. Vestn Otorinolaringol; 2009;(1):61-6
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Current concepts of diagnosis and treatment of acoustic neurinomas].
  • [MeSH-major] Diagnostic Techniques, Otological / trends. Neuroma, Acoustic. Otologic Surgical Procedures / trends. Radiosurgery / trends. Radiotherapy, Conformal / trends

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19373997.001).
  • [ISSN] 0042-4668
  • [Journal-full-title] Vestnik otorinolaringologii
  • [ISO-abbreviation] Vestn. Otorinolaringol.
  • [Language] rus
  • [Publication-type] Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 56
  •  go-up   go-down


22. Ellies M, Laskawi R: [Mimic rehabilitation after removal of acoustic neurinomas: The Goettingen Concept]. Laryngorhinootologie; 2005 Sep;84(9):647-50
MedlinePlus Health Information. consumer health - Botox.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mimic rehabilitation after removal of acoustic neurinomas: The Goettingen Concept].
  • [MeSH-major] Botulinum Toxins, Type A / administration & dosage. Facial Nerve / surgery. Facial Paralysis / rehabilitation. Facies. Hypoglossal Nerve / surgery. Neuroma, Acoustic / surgery. Neuromuscular Agents / administration & dosage. Postoperative Complications

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - After Surgery.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16217887.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neuromuscular Agents; EC 3.4.24.69 / Botulinum Toxins, Type A
  •  go-up   go-down


23. Firat AK, Karakaş HM, Kahraman B, Firat Y, Altinok T, Kizilay A: [Dynamic contrast-enhanced magnetic resonance imaging findings of mass lesions of the pontocerebellar angle]. Kulak Burun Bogaz Ihtis Derg; 2007;17(4):217-23
MedlinePlus Health Information. consumer health - MRI Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we investigated the role of dynamic contrast-enhanced MRI in the differential diagnosis of acoustic neurinoma, meningioma, and paraganglioma.
  • PATIENTS AND METHODS: Twelve patients (8 females, 4 males; mean age 47.5 years; range 8 to 71 years) whose diagnoses were acoustic neurinoma (n=3), paraganglioma (n=5), and meningioma (n=4) were evaluated by simultaneous conventional and dynamic contrast-enhanced MRI.
  • RESULTS: According to the four main time-signal intensity curve patterns described in the literature, acoustic neurinomas, meningiomas, and paragangliomas exhibited type C, type A-B, and type A curve patterns, respectively.
  • CONCLUSION: Our results suggest that dynamic contrast MRI may have an additional but limited role in the differential diagnosis of extra-axial intracranial tumors such as those of the pontocerebellar angle.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebellopontine Angle / pathology. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Contrast Media. Female. Humans. Male. Meningioma / pathology. Middle Aged. Neuroma, Acoustic / pathology. Paraganglioma / pathology. Predictive Value of Tests

  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18187974.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Contrast Media
  •  go-up   go-down


24. Sugita-Kitajima A, Koizuka I: Evaluation of the vestibulo-ocular reflex using sinusoidal off-vertical axis rotation in patients with acoustic neurinoma. Neurosci Lett; 2009 Oct 2;462(1):6-9
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the vestibulo-ocular reflex using sinusoidal off-vertical axis rotation in patients with acoustic neurinoma.
  • The vestibulo-ocular reflex (VOR) was studied to examine the utility of off-vertical axis rotation (OVAR) in the diagnosis of acoustic neurinoma.
  • Thirteen patients with acoustic neurinomas were investigated.
  • Results showed that VOR gain during OVAR at 0.8 Hz and in a 30 degrees nose-up position in patients with internal auditory canal tumors was significantly less than the gain measured during EVAR.
  • The VOR gain measured from all patients (including those with tumors extending to the cerebellopontine angle) was not significantly different when the patients were subjected to EVAR and OVAR.
  • These observations were possibly due to superior vestibular nerve dysfunction.
  • We concluded that certain stimulating parameters--patient's nose tilted up 30 degrees; sinusoidal OVAR at 0.8 Hz and 60 degrees /s maximum angular head velocity--were useful for evaluating vestibular function in patients suffering from an acoustic neurinoma located within the internal auditory canal.
  • [MeSH-major] Ear Neoplasms / diagnosis. Neuroma, Acoustic / diagnosis. Reflex, Vestibulo-Ocular. Rotation

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19560514.001).
  • [ISSN] 1872-7972
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


25. Knipping S, Fabricius A, Kösling S, Bloching M: [Intracochlear schwannoma as a cause of a deafness: a case report]. HNO; 2007 Aug;55(8):641-3
MedlinePlus Health Information. consumer health - Hearing Disorders and Deafness.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intracochlear schwannoma as a cause of a deafness: a case report].
  • [Transliterated title] Intrakochleäres Schwannom als Ursache für eine Surditas: Eine Falldarstellung.
  • Inner ear extension caused by schwannomas, which can cause hearing loss, tinnitus and vertigo, is an extremely rare finding.
  • From the MRI aspect, this appeared to be a small intracochlear schwannoma.
  • A precise imaging via HR-MRI is required to detect intracochlear schwannomas.
  • The option of radiotherapy for the treatment of intrameatal acoustic neurinomas should be considered.
  • [MeSH-major] Cochlear Diseases / complications. Cochlear Diseases / diagnosis. Deafness / diagnosis. Deafness / etiology. Ear Neoplasms / complications. Ear Neoplasms / diagnosis. Neurilemmoma / complications. Neurilemmoma / diagnosis

  • Genetic Alliance. consumer health - Deafness.
  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16741722.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  •  go-up   go-down


26. Fogliata A, Clivio A, Nicolini G, Vanetti E, Cozzi L: Intensity modulation with photons for benign intracranial tumours: a planning comparison of volumetric single arc, helical arc and fixed gantry techniques. Radiother Oncol; 2008 Dec;89(3):254-62
MedlinePlus Health Information. consumer health - Pituitary Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intensity modulation with photons for benign intracranial tumours: a planning comparison of volumetric single arc, helical arc and fixed gantry techniques.
  • BACKGROUND AND PURPOSE: The potential benefits and limitations of the new RapidArc treatment concept compared to Helical Tomotherapy and fixed gantry intensity modulation techniques have been assessed at treatment planning level on 12 patients presenting with 'benign' brain tumours.
  • MATERIALS AND METHODS: Plans for five acoustic neurinomas, five meningiomas and two pituitary adenomas were computed for an Helical Tomotherapy (HT) unit, for RapidArc delivery (RA) on a linac equipped with two types of MLC (RA_HD120 with the new High Definition MLC with 2.5mm leaf width at isocentre and RA_M120 with the standard Millennium with 5mm resolution) and for fixed beam IMRT with the High Definition MLC.
  • [MeSH-major] Adenoma / radiotherapy. Brain Neoplasms / radiotherapy. Meningioma / radiotherapy. Neuroma, Acoustic / radiotherapy. Pituitary Neoplasms / radiotherapy. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Intensity-Modulated / methods

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18760851.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


27. Lan Q, Qian ZY, Chen J, Liu SH, Lu ZH, Huang Q: [Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches]. Zhonghua Yi Xue Za Zhi; 2005 Jan 26;85(4):219-23
MedlinePlus Health Information. consumer health - Childhood Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches].
  • OBJECTIVE: To explore the surgical outcome and skills of keyhole approaches to posterior cranial fossa tumors.
  • METHODS: A retrospective analysis of the clinical data of 43 consecutive patients with posterior cranial fossa tumors, including acoustic neurinoma, petroclival meningioma, pons tumor, fourth ventricular tumor, etc. was conducted.
  • Subtemporal, retromastoid, or middle suboccipital keyhole approach was chosen respectively according to the anatomic positions of those different tumors.
  • RESULTS: The tumors were totally removed in 37 of the 43 patients (86.0%), subtotally removed in 5 (11.6%) and mostly removed in 1 (2.3%).
  • All of the 18 acoustic neurinomas (100%) were totally removed and the facial nerves of 15 patients (83.3%) were preserved anatomically, however, one patient died of brain stem edema on the 2nd postoperative day.
  • Among the 6 pons tumors 3 were removed totally and 3 subtotally.
  • All the other tumors were resected completely without neurological dysfunction observed, however, one patient with a cholesteatoma failed to demonstrate apparent improvement in his diplopia.
  • CONCLUSION: Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches, with safe, succinct and minimally invasive property, is one of the promising directions in modern neurosurgery.
  • [MeSH-major] Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15854477.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  •  go-up   go-down


28. Cozzi L, Clivio A, Bauman G, Cora S, Nicolini G, Pellegrini R, Vanetti E, Yartsev S, Fogliata A: Comparison of advanced irradiation techniques with photons for benign intracranial tumours. Radiother Oncol; 2006 Aug;80(2):268-73
MedlinePlus Health Information. consumer health - Brain Tumors.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of advanced irradiation techniques with photons for benign intracranial tumours.
  • BACKGROUND AND PURPOSE: The potential benefits and limitations of different radiation techniques (stereotactic arc therapy (SRS/T), intensity modulated radiotherapy (IMRT), helical tomotherapy (HT), Cyberknife and intensity-modulated multiple arc therapy (AMOA)) have been assessed using comparative treatment planning methods on twelve patients presenting with 'benign' brain tumours.
  • MATERIALS AND METHODS: Plans for five acoustic neurinomas, five meningiomas and two pituitary adenomas were computed to generate dose distributions for all modalities using a common CT dataset to delineate planning target volume and organs at risk.
  • For organs at risk all techniques respected planning objectives with a tendency of Cyberknife and SRS/T to better spare the brain stem and the healthy brain tissue (e.g., V(20Gy) of 2.0% and 2.3%, respectively, compared to 3.1-5.0% for the other techniques).
  • [MeSH-major] Brain Neoplasms / radiotherapy. Photons / therapeutic use
  • [MeSH-minor] Humans. Meningioma / radiotherapy. Neurilemmoma / radiotherapy. Radiotherapy, Intensity-Modulated / methods. Stereotaxic Techniques. Tomography, Spiral Computed / methods

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16890315.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


29. Jeblaoui Y, Neji B, Haddad S, Mnif D, Hchicha S: [Difficulties of the management of head and neck neurofibromatosis]. Ann Chir Plast Esthet; 2007 Feb;52(1):43-50
MedlinePlus Health Information. consumer health - Head and Neck Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Difficultés de la prise en charge des atteintes de l'extrémité céphalique dans les neurofibromatoses.
  • Neurofibromatosis type 1 (NF1) or Von Recklinghausen's neurofibromatosis is an autosomal dominantly inherited disease, whose prevalence is 1/4500.
  • Neurofibromatosis type 2 (NF2) is also an autosomal dominantly inherited disease, but is ten times less frequent than the NF1 and is characterized by bilateral vestibular schwannomas (former acoustic neurinomas).
  • Surgical resection of the tumor was carried out among 8 patients with bone reconstruction of the orbit on 3 patients and cutaneous expansion on one other.
  • However, all our patients were satisfied with the result and we noted recurrence in a patient presenting a retro-auricular tumor, which filled the external auditory canal requiring a further surgery.
  • Cancer risks and the disease's completely unpredictable evolution urge a regular and multidisciplinary patient follow-up.

  • Genetic Alliance. consumer health - Neurofibromatosis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17137698.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
  •  go-up   go-down


30. Poltermann S, Schlehofer B, Steindorf K, Schnitzler P, Geletneky K, Schlehofer JR: Lack of association of herpesviruses with brain tumors. J Neurovirol; 2006 Apr;12(2):90-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lack of association of herpesviruses with brain tumors.
  • Gliomas are the most frequent primary brain tumors in humans.
  • Recently, human cytomegalovirus (HCMV) gene products and nucleic acids were reported to be present in all of 27 glioma samples investigated in contrast to other brain tissues, and it was hypothesized that HCMV might play a role in glioma pathogenesis.
  • To evaluate these findings, samples of 40 gliomas, 31 meningiomas, and 6 acoustic neurinomas (ACNs) were analyzed for the presence of HCMV macromolecules using polymerase chain reaction (PCR) and immunohistochemistry.
  • Additionally, corresponding blood samples from 72 patients were analyzed for the presence of HCMV DNA to check for a possible contamination of tumor tissues with HCMV-infected blood cells.
  • No HCMV DNA sequences were found, neither in brain tumor tissues nor in corresponding blood samples.
  • Serological analyses of brain tumor patients showed no significant differences in the prevalences of antibodies to HCMV, HSV, EBV, or VZV compared to the general population.
  • Thus, the data of the present study do not support the hypothesis of an association of herpesviruses with the development of primary brain tumors.
  • [MeSH-major] Brain Neoplasms / virology. Cytomegalovirus / isolation & purification. Glioma / virology. Meningeal Neoplasms / virology. Meningioma / virology. Neuroma, Acoustic / virology

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - Brain Tumors.
  • MedlinePlus Health Information. consumer health - Childhood Brain Tumors.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] J Neurovirol. 2007;13(1):85; author reply 86-7 [17454453.001]
  • (PMID = 16798670.001).
  • [ISSN] 1355-0284
  • [Journal-full-title] Journal of neurovirology
  • [ISO-abbreviation] J. Neurovirol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  •  go-up   go-down


31. Chihara Y, Ito K, Sugasawa K, Shin M: Neurological complications after acoustic neurinoma radiosurgery: revised risk factors based on long-term follow-up. Acta Otolaryngol Suppl; 2007 Dec;(559):65-70
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neurological complications after acoustic neurinoma radiosurgery: revised risk factors based on long-term follow-up.
  • CONCLUSIONS: The precise risk factors for neurological complications after acoustic neurinoma radiosurgery were identified on long-term follow-up.
  • Type 2 neurofibromatosis was found to be a risk factor for hearing loss and peripheral tumor dose was a risk factor for seventh and fifth cranial nerve injuries.
  • At the present time, controversy exists regarding history of prior surgical resection and tumor size as risk factors for cranial nerve complications.
  • PATIENTS AND METHODS: Between June 1990 and September 1998, 138 patients with acoustic neurinomas had SRS at Tokyo University Hospital.
  • The average tumor diameter ranged from 6.7 to 25.4 mm (mean 13.9 mm).
  • The maximum tumor doses ranged from 20 to 40 Gy (mean 29.8 Gy), and the peripheral doses ranged from 12 to 25 Gy (mean 15.4 Gy).
  • The neurological complications studied included hearing loss, facial palsy, and trigeminal nerve dysfunction.
  • The variables analyzed were age, gender, prior operation, neurofibromatosis type 2 (NF2), tumor diameter, maximum tumor dose, peripheral tumor irradiation dose, and the number of isocenters.
  • RESULTS: NF2 was significantly correlated with both total hearing loss and pure tone threshold (PTA) elevation; a history of prior surgical resection, tumor size, and the peripheral tumor dose were significantly correlated with facial palsy; and the peripheral tumor dose was significantly correlated with trigeminal neuropathy.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Aged. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / etiology. Female. Follow-Up Studies. Hearing Disorders / epidemiology. Hearing Disorders / etiology. Humans. Male. Middle Aged. Neurofibromatosis 2 / epidemiology. Neurofibromatosis 2 / etiology. Prevalence. Radiosurgery / instrumentation. Risk Factors. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / etiology

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18340560.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  •  go-up   go-down


32. Yonekawa Y: [Operative neurosurgery: personal view and historical backgrounds (2) acoustic neurinoma]. No Shinkei Geka; 2006 Dec;34(12):1265-80
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Operative neurosurgery: personal view and historical backgrounds (2) acoustic neurinoma].
  • Microsurgical removal of acoustic neurinoma is still one of the challenging topics in neurosurgery in spite of the development of Gamma-knife or radiosurgery, with which small and moderate sized tumors can be treated.
  • Surgical technique necessitates more expertise in dealing with larger tumors.
  • In this report ongoing microsurgical standard technique for removal of acoustic neurinomas of approx.
  • 3) Intracapsular enucleation after the dural incision and retraction of the biventer lobule with special emphasis on the infrequent anatomical course of the facial and vestibulocochlear nerves on the posterior wall of neurinomas.
  • 4) Localizing the facial nerve and vestibulocochlear nerve at the pontine side, so that decision of preserving or sacrificing the latter in the course of surgery can be made from the viewpoint of hearing preservation and concentrate on facial nerve function.
  • 6) Reduction of remaining tumor-capsule volume by sharp dissection or bipolar cutting, using intraoperative EMG-stimulation which identifies the presence of flattened facial nerve fibers on the capsule.
  • Presence tiny remnant of the tumor capsule attached to the nerve bundles just before the entrance of internal acoustic porus (macroscopical "radical" resection) is considered to be acceptable for better postoperative quality of life.
  • 9) Results of 88 cases during last 10 years are: good function (HB I and II) of the facial nerve 90.5% at the time of two years follow-up, 11.5% hearing preservation, 1 mortality due to aspiration pneumonia.
  • [MeSH-major] Microsurgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Radiosurgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17154074.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


33. Takeda T, Kakigi A, Takebayashi S, Ohono S, Nishioka R, Nakatani H: Narrow-band evoked oto-acoustic emission from ears with normal and pathologic conditions. ORL J Otorhinolaryngol Relat Spec; 2010;71 Suppl 1:41-56
MedlinePlus Health Information. consumer health - Meniere's Disease.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Narrow-band evoked oto-acoustic emission from ears with normal and pathologic conditions.
  • CONCLUSION: Evoked oto-acoustic emission (EOAE), in particular the slow component, is fragile with the inner ear lesions and is apt to disappear in impaired ears.
  • EOAE testing was performed in 40 normal ears and 111 ears with pathologic disorders, including sudden deafness, Ménière's disease and surgically proven acoustic neurinomas.
  • Spontaneous oto-acoustic emission was investigated in some cases.
  • In acoustic neurinoma, especially computed tomography scan and magnetic resonance imaging tests were performed to assess the tumor size. RESULTS:.
  • The prognosis of sudden deafness was good in cases where both a fast component and slow component were detected in the acute stage within 2 weeks after the deafness onset, and was pessimistic, when either or both of them failed to recover. (3) In Ménière's disease, EOAE was found in 6 (40%) of 15 cases with hearing loss >50 dB, and detected in 54 (90%) of 60 cases with slight to moderate deafness <50 dB HL.
  • Ultimately, the fast component also faded out if the hearing was severely impaired. (4) EOAEs were detectable in 20 (95.2%) of 21 ears with surgically proven acoustic neurinoma, 16 of which had both the slow and fast components.
  • The echo pattern of acoustic neurinoma was basically similar to that of normal ears, but the detection threshold was elevated to a varying degree, although there were some cases with much better detection threshold as compared with severe deafness.
  • [MeSH-major] Deafness / physiopathology. Meniere Disease / physiopathology. Neuroma, Acoustic / physiopathology. Otoacoustic Emissions, Spontaneous / physiology

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - Hearing Disorders and Deafness.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20185949.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


34. Chang LS, Welling DB: Molecular biology of vestibular schwannomas. Methods Mol Biol; 2009;493:163-77
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular biology of vestibular schwannomas.
  • Recent advances in molecular biology have led to a better understanding of the etiology of vestibular schwannomas.
  • The underlying purpose of vestibular schwannoma research is the development of new treatment options; however, such options have not yet been established.
  • A fundamental understanding of the underlying molecular events leading to tumor formation began when mutations in the neurofibromatosis type 2 (NF2) tumor suppressor gene were identified in vestibular schwannomas.
  • The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 (NF2) syndromes have both been related to alterations in the NF2 gene.
  • When utilized with clinical screening, such as magnetic resonance imaging (MRI), conventional audiometry, and auditory brainstem response (ABR), the early detection of NF2 can be made, which consequently makes a significant difference in the ability to successfully treat vestibular schwannomas.
  • Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing.
  • [MeSH-major] Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Animals. DNA Mutational Analysis. Genetic Predisposition to Disease. Humans. Magnetic Resonance Imaging. Mice. Mice, Knockout. Mice, SCID. Mice, Transgenic. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / pathology

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18839347.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
  •  go-up   go-down


35. Mackle T, Rawluk D, Walsh RM: Atypical clinical presentations of vestibular schwannomas. Otol Neurotol; 2007 Jun;28(4):526-8
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical clinical presentations of vestibular schwannomas.
  • A significant number of patients with vestibular schwannomas present atypically, with none of the classical symptoms of unilateral sensorineural hearing loss, tinnitus, and/or dysequilibrium.
  • STUDY DESIGN: The clinical data of all patients who presented to the vestibular schwannoma clinic at Beaumont Hospital over the past 12 years was prospectively recorded in a computerized database.
  • CONCLUSION: A significant subgroup, 3.7% in our study, did not present with the audiovestibular symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Neuroma, Acoustic / diagnosis

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17414179.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


36. Propp JM, McCarthy BJ, Davis FG, Preston-Martin S: Descriptive epidemiology of vestibular schwannomas. Neuro Oncol; 2006 Jan;8(1):1-11
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Descriptive epidemiology of vestibular schwannomas.
  • Vestibular schwannomas, commonly termed acoustic neuromas, arise from the vestibular branch of the eighth cranial nerve (acoustic nerve) and are benign, slow-growing brain tumors that negatively impact patient quality of life.
  • They are thought to account for the majority of intracranial nerve sheath tumors.
  • To describe incidence rate patterns and trends of primary nerve sheath tumors of the brain/CNS and the subset of vestibular schwannomas in two population-based incidence registries, data were obtained from 11 Central Brain Tumor Registry of the United States (CBTRUS) collaborating state registries and the Los Angeles County Cancer Surveillance Program (LACCSP) (1975-1998).
  • Multiplicative Poisson regression models were used to compare trends in primary nerve sheath tumors of the brain/CNS overall and in subgroups, including vestibular schwannomas, controlling for age, gender, race, microscopic confirmation, and region.
  • The overall incidence of primary nerve sheath tumors of the brain/CNS was 1.1 per 100,000 person-years (CBTRUS, 1995-1999 and LACCSP, 1995-1998).
  • The incidence of vestibular schwannomas was similar for both data sets: 0.6 per 100,000 person-years (CBTRUS, 1995-1999) and 0.8 per 100,000 person-years (LACCSP, 1995-1998).
  • Moreover, the incidence of primary nerve sheath tumors of the brain/CNS overall (CBTRUS, 1985-1999 and LACCSP, 1975-1998) and of vestibular schwannomas (CBTRUS, 1992-1999 and LACCSP, 1992-1998) increased over time.
  • However, the incidence of benign schwannomas in sites other than the acoustic nerve either decreased (CBTRUS, 1992-1999) or experienced no significant change (LACCSP, 1992-1998).
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Registries

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Epidemiol. 1992 Jun 15;135(12):1349-57 [1510081.001]
  • [Cites] J Natl Cancer Inst. 1992 Mar 18;84(6):442-5 [1538422.001]
  • [Cites] Ann Neurol. 1995 Jan;37(1):67-73 [7818260.001]
  • [Cites] Laryngoscope. 1999 May;109(5):736-40 [10334223.001]
  • [Cites] Stat Med. 2000 Feb 15;19(3):335-51 [10649300.001]
  • [Cites] Am J Otol. 2000 Sep;21(5):690-4 [10993460.001]
  • [Cites] N Engl J Med. 2001 Jan 11;344(2):79-86 [11150357.001]
  • [Cites] J Natl Cancer Inst. 2001 Feb 7;93(3):203-7 [11158188.001]
  • [Cites] Neuro Oncol. 2001 Jul;3(3):141-51 [11465394.001]
  • [Cites] Neurology. 2002 Apr 23;58(8):1304-6 [11971109.001]
  • [Cites] Neuroepidemiology. 2003 Mar-Apr;22(2):124-9 [12629278.001]
  • [Cites] Am J Epidemiol. 2004 Feb 1;159(3):277-83 [14742288.001]
  • [Cites] J Toxicol Environ Health B Crit Rev. 2004 Sep-Oct;7(5):351-84 [15371240.001]
  • [Cites] Epidemiology. 2004 Nov;15(6):653-9 [15475713.001]
  • [Cites] Health Care Financ Rev. 1984 Winter;6(2):1-29 [10310949.001]
  • [Cites] N Engl J Med. 1988 Oct 20;319(16):1033-9 [3173432.001]
  • [Cites] Br J Cancer. 1989 May;59(5):783-6 [2736213.001]
  • [Cites] Neuroepidemiology. 1989;8(6):283-95 [2586698.001]
  • [Cites] Cancer. 1992 Mar 1;69(5):1300-6 [1739929.001]
  • [Cites] Brain Pathol. 1993 Jul;3(3):255-68 [8293185.001]
  • (PMID = 16443943.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1871924
  •  go-up   go-down


37. Arthurs BJ, Lamoreaux WT, Giddings NA, Fairbanks RK, Mackay AR, Demakas JJ, Cooke BS, Lee CM: Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature. World J Surg Oncol; 2009;7:100
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature.
  • Vestibular schwannomas, also called acoustic neuromas, are benign tumors of the vestibulocochlear nerve.
  • Unfortunately, definitive guidelines for treating vestibular schwannomas are lacking, because of insufficient evidence comparing the outcomes of therapeutic modalities.We present a contemporary case report, describing the finding of a vestibular schwannoma in a patient who presented with dizziness and a "clicking" sensation in the ear, but no hearing deficit.
  • Audible clicking is a symptom that, to our knowledge, has not been associated with vestibular schwannoma in the literature.
  • This case highlights an atypical presentation of vestibular schwannoma, associated with audible "clicks" and normal hearing.
  • We also provide a concise review of the available literature on modern vestibular schwannoma treatment, which may be useful in guiding treatment decisions.
  • [MeSH-major] Neurilemmoma / surgery. Neuroma, Acoustic / surgery. Radiosurgery. Vestibular Nerve / surgery

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Laryngoscope. 2000 Nov;110(11):1850-6 [11081598.001]
  • [Cites] Neurosurgery. 2009 Apr;64(4):654-61; discussion 661-3 [19197222.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2002 Dec 1;54(5):1410-21 [12459364.001]
  • [Cites] Neurol Res. 2003 Oct;25(7):682-90 [14579782.001]
  • [Cites] Otolaryngol Head Neck Surg. 2004 May;130(5):611-6 [15138429.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2004 Sep 1;60(1):225-30 [15337560.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):275-80 [8892449.001]
  • [Cites] Neurosurgery. 1997 Jan;40(1):1-9; discussion 9-10 [8971818.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1999 Jan 15;43(2):305-11 [10030254.001]
  • [Cites] Am J Otol. 1999 Jul;20(4):495-9 [10431892.001]
  • [Cites] Laryngoscope. 2005 Mar;115(3):450-4 [15744156.001]
  • [Cites] Cancer. 2005 Aug 1;104(3):580-90 [15952200.001]
  • [Cites] Neuro Oncol. 2006 Jan;8(1):1-11 [16443943.001]
  • [Cites] Neurosurgery. 2006 Jul;59(1):77-85; discussion 77-85 [16823303.001]
  • [Cites] Otol Neurotol. 2006 Aug;27(5):705-12 [16868519.001]
  • [Cites] Otolaryngol Clin North Am. 2007 Jun;40(3):571-88, ix [17544696.001]
  • [Cites] Acta Neurochir (Wien). 2007;149(7):647-60; discussion 660 [17558460.001]
  • [Cites] Clin Otolaryngol. 2008 Jun;33(3):255-9 [18559034.001]
  • [Cites] J Neurosurg. 2008 Dec;109 Suppl:129-36 [19123899.001]
  • [Cites] Otol Neurotol. 2002 Jul;23(4):534-41 [12170158.001]
  • (PMID = 20021676.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803477
  •  go-up   go-down


38. Régis J, Roche PH, Delsanti C, Thomassin JM, Ouaknine M, Gabert K, Pellet W: Modern management of vestibular schwannomas. Prog Neurol Surg; 2007;20:129-41
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modern management of vestibular schwannomas.
  • Within the last 3 decades, microsurgery and stereotactic radiosurgery (SRS) have become well-established management options for vestibular schwannomas (VSs).
  • A long-term tumor control rate of 97%, transient facial palsy lower than 1%, and a probability of functional hearing preservation between 50 and 95% was achieved in this large series of patients treated with state-of-the-art SRS.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17317981.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


39. Archibald DJ, Neff BA, Voss SG, Splinter PL, Driscoll CL, Link MJ, Dong H, Kwon ED: B7-H1 expression in vestibular schwannomas. Otol Neurotol; 2010 Aug;31(6):991-7
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] B7-H1 expression in vestibular schwannomas.
  • HYPOTHESIS: B7-H1 is expressed in vestibular schwannomas.
  • BACKGROUND: Little is known about how benign human vestibular schwannomas interact with antibody-mediated or cell-mediated immunity.
  • We report on the aberrant expression of a novel T-cell coregulatory molecule, B7 homolog 1 (B7-H1), in vestibular schwannomas and discuss the implications of B7-H1 expression and tumor aggressiveness and a potential regulator of B7-H1 expression.
  • METHODS: Immunohistochemical staining for B7-H1, CD8+, CD3+, and CD4+ lymphocytes were performed on 48 fresh-frozen vestibular schwannoma tissue specimens.
  • A clinical review of patient presenting symptoms and tumor characteristics was performed.
  • Real-time polymerase chain reaction was used to determine if there was differential expression of B7-H1 messenger RNA and microRNA-513, a known regulator of B7-H1, in several strongly positive and negative B7-H1 vestibular schwannomas.
  • RESULTS: Nine (19%) of 48 tumors were negative, 23 (48%) tumors were 1+ mildly positive (<20% section area), and 16 (33%) stained 2+ strongly positive (>or=20% section area) for B7-H1.
  • The average number of CD8 cells per high-power field was 2.1 for positive-staining tumors and 1.0 for negative tumors (p = 0.16).
  • Failure of tumor control with stereotactic radiation (p = 0.029) was significantly greater in the strongly positive B7-H1 tumors.
  • Real-time polymerase chain reaction did not show significant differential expression of microRNA-513 (p = 0.62) or B7-H1 messenger RNA (p = 0.35) between the tumors showing strong and negative immunohistochemical staining for B7-H1 protein.
  • CONCLUSION: Vestibular schwannoma tumors express B7-H1, which has been associated with immune tolerance and adverse disease characteristics in several malignancies.
  • Growing tumors that were surgically removed after failed stereotactic radiation therapy were significantly more likely to strongly express B7-H1 protein, which lends some credibility to the hypothesis that immuno-evasion may play some role in their continued growth.
  • Although clinical trends were seen, greater statistical power is required to evaluate whether B7-H1 expression correlates with more aggressive tumor growth or poorer hearing class.
  • B7-H1 seems to be expressed in equal amounts at the RNA level in all vestibular schwannoma tumors that suggests that differential protein expression is occurring at the posttranscriptional level.
  • However, microRNA-513 does not regulate B7-H1 protein expression in these tumors.

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20601920.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA134345-03; United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS242934; NLM/ PMC4810681
  •  go-up   go-down


40. Ambett R, Rupa V, Rajshekhar V: Analysis of causes for late presentation of Indian patients with vestibular schwannoma. J Laryngol Otol; 2009 May;123(5):502-8
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of causes for late presentation of Indian patients with vestibular schwannoma.
  • OBJECTIVE: To determine the causes of delay in diagnosis and treatment of Indian patients with vestibular schwannomas.
  • METHODS: In a prospective study from 2003 to 2005, 50 patients with a confirmed diagnosis of vestibular schwannoma were interviewed to determine the causes for (1) the delay between the patient noting the initial symptom and the definitive diagnosis, and (2) the reasons for delayed diagnosis.
  • After the patient had noted symptoms, the diagnosis of vestibular schwannoma was delayed due to doctor-related causes in 80 per cent of cases, and due to patient-related causes in 20 per cent.
  • CONCLUSIONS: Delay in the diagnosis of vestibular schwannoma in Indian patients is due to both doctor- and patient-related factors.
  • [MeSH-major] Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Health Knowledge, Attitudes, Practice. Humans. India. Male. Middle Aged. Prospective Studies. Referral and Consultation / standards. Time Factors. Tinnitus / etiology. Vertigo / etiology. Vestibular Function Tests. Young Adult

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18808730.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


41. Roche PH, Bouvier C, Chinot O, Figarella-Branger D: Genesis and biology of vestibular schwannomas. Prog Neurol Surg; 2008;21:24-31
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genesis and biology of vestibular schwannomas.
  • This review chapter is a synthesis of the recent literature about pathogenesis of schwannomas with emphasis on vestibular schwannomas (VSs).
  • The cornerstone of cellular transformation and proliferation of Schwann cells toward schwannomas has been attributed to the nonexpression of normal schwannomin/merlin (S/M) by these cells.
  • The understanding of this mechanism has been gained from molecular genetic studies of neurofibromatosis type 2 (NF2) patients, in whom mutations of a tumor suppressor gene (NF2 gene) was clearly identified.
  • Lack of normal S/M protein in the schwannoma cell is due to gene mutation in 50% of sporadic VSs.
  • The exact interactions of S/M with extracellular matrix, membranous glycoprotein and cytoskeleton are not fully understood.
  • However, it is recognized that these interactions activate several pathways that might regulate cell-cycle process, apoptosis and intercellular interaction.
  • Apart from the involvement of the S/M pathway, the authors review the potential role of other genetic abnormalities and growing factors that are supposed to be involved in the pathogenesis of vs. Understanding the pathways of action and regulation of S/M may provide the basics for identifying potential therapeutic targets, which is of paramount importance for a better management of NF2 patients.
  • [MeSH-major] Genes, Neurofibromatosis 2 / physiology. Neurofibromin 2 / physiology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18810196.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Neurofibromin 2
  • [Number-of-references] 43
  •  go-up   go-down


42. Whitehouse K, Foroughi M, Shone G, Hatfield R: Vestibular schwannomas - when should conservative management be reconsidered? Br J Neurosurg; 2010 Apr;24(2):185-90
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannomas - when should conservative management be reconsidered?
  • OBJECTIVE: To document the natural history of vestibular schwannomas treated conservatively, and to find if there are any predictive factors for growth and need for active intervention.
  • SUBJECTS: Eighty-eight patients managed conservatively for unilateral vestibular schwannoma and that have had at least two radiological investigations.
  • RESULTS: Of the 88 patients, the average size of schwannoma at diagnosis was 10.88 mm.
  • 51.1% of schwannomas grew, 12.5% shrank and 36.4% remained the same size.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiography. Radiosurgery / methods
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Risk Factors. Treatment Outcome. Tumor Burden

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19886818.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


43. Shchekut'ev GA, Shimanskiĭ VN, Ogurtsova AA, Semenov MS: [Identification of the cochlear nerve in surgical removal of vestibular schwannomas]. Zh Vopr Neirokhir Im N N Burdenko; 2009 Jul-Sep;(3):10-3; discussion 13-4
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Identification of the cochlear nerve in surgical removal of vestibular schwannomas].
  • Review of methods which allow intraoperative identifying and monitoring of cochlear and facial nerves in resection of vestibular schwannomas is presented.
  • We describe a case of successful identification and functional preservation of facial and cochlear nerves in a patient with acoustic neuroma.
  • According to some authors, application of intraoperative neurophysiological techniques in surgery of vestibular schwannomas allows to preserve not only anatomical but also functional integrity of neural structures as well.
  • [MeSH-major] Cochlear Nerve / physiology. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20088443.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  •  go-up   go-down


44. Jaiswal S, Agrawal V, Jaiswal AK, Pandey R, Mahapatra AK: Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance. J Negat Results Biomed; 2009;8:9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance.
  • OBJECTIVE: The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity.
  • MATERIALS AND METHODS: The study included 100 cases of vestibular schwannomas operated from January 2006 to June 2009.
  • Formaldehyde-fixed parafiin-embedded archival vestibular schwannomas specimens were used for the immunohistochemical assessment of estrogen and progesterone receptors.
  • CONCLUSION: No estrogen and progesterone receptor could be found in any of our 100 cases of vestibular schwannomas.
  • Hence our study does not support a causative role of estrogen and progesterone in the growth of vestibular schwannoma as well as hormonal manipulation in the treatment of this tumor.
  • [MeSH-major] Neurilemmoma / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Vestibular Diseases / metabolism

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Acta Otolaryngol. 2000 Oct;120(8):950-4 [11200590.001]
  • [Cites] J Clin Pathol. 2004 Feb;57(2):168-71 [14747443.001]
  • [Cites] Surg Neurol. 1981 Feb;15(2):105-9 [7245001.001]
  • [Cites] Surg Neurol. 1986 Aug;26(2):142-8 [3726740.001]
  • [Cites] Eur J Surg Oncol. 1987 Aug;13(4):303-7 [3622783.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 1990 Feb;116(2):202-4 [2297415.001]
  • [Cites] J Laryngol Otol. 2008 Feb;122(2):125-7 [17666143.001]
  • [Cites] Otolaryngol Head Neck Surg. 1990 Sep;103(3):377-9 [2122366.001]
  • [Cites] J Laryngol Otol. 1990 Nov;104(11):865-7 [1702456.001]
  • [Cites] Laryngoscope. 1995 Jul;105(7 Pt 1):693-700 [7603272.001]
  • [Cites] Neurosurgery. 1995 Sep;37(3):496-503; discussion 503-4 [7501116.001]
  • [Cites] Acta Neurochir (Wien). 1997;139(3):188-92; discussion 193 [9143583.001]
  • [Cites] Am J Otol. 1990 Jul;11(4):237-9 [2399940.001]
  • (PMID = 19889208.001).
  • [ISSN] 1477-5751
  • [Journal-full-title] Journal of negative results in biomedicine
  • [ISO-abbreviation] J Negat Results Biomed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC2777842
  •  go-up   go-down


45. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):589-609, ix-x
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / etiology. Headache / epidemiology. Headache / etiology. Humans. Meningitis / epidemiology. Meningitis / etiology. Neoplasm Recurrence, Local. Postoperative Complications. Postural Balance / physiology. Tinnitus / epidemiology. Tinnitus / etiology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17544697.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
  •  go-up   go-down


46. Lobato-Polo J, Kondziolka D, Zorro O, Kano H, Flickinger JC, Lunsford LD: Gamma knife radiosurgery in younger patients with vestibular schwannomas. Neurosurgery; 2009 Aug;65(2):294-300; discussion 300-1
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery in younger patients with vestibular schwannomas.
  • OBJECTIVE: Management options for patients with vestibular schwannoma include observation, surgical resection, stereotactic radiosurgery (SRS), and stereotactic radiation therapy.
  • We studied tumor response and clinical outcomes after SRS in such patients.
  • METHODS: We reviewed long-term outcomes in 55 patients with vestibular schwannomas.
  • The median tumor volume was 1.7 mm.
  • The median tumor margin dose was 13.0 Gy (range, 11-20 Gy).
  • At the last assessment, facial and trigeminal nerve function was preserved in 98.2% and 96.4% of patients, respectively; the only facial deficit (House-Brackmann grade III) occurred in a patient who received a tumor dose of 20 Gy early in our experience (1988).
  • No patient developed a secondary radiation-related tumor.
  • CONCLUSION: Our experience indicates that GK SRS is an effective management strategy for younger patients with vestibular schwannoma, most of whom have no additional cranial nerve dysfunction.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / statistics & numerical data. Vestibular Nerve / surgery
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Cochlear Nerve / physiopathology. Cochlear Nerve / radiation effects. Facial Nerve / physiopathology. Facial Nerve / radiation effects. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Female. Hearing Loss, Sensorineural / epidemiology. Hearing Loss, Sensorineural / prevention & control. Humans. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Radiation Dosage. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / physiopathology. Trigeminal Nerve / radiation effects. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / prevention & control. Young Adult

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - After Surgery.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19625908.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


47. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. 2007. Neurosurg Clin N Am; 2008 Apr;19(2):331-43, vii
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas. 2007.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18534343.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Bennett M; Haynes DS
  •  go-up   go-down


48. Battista RA: Gamma knife radiosurgery for vestibular schwannoma. Otolaryngol Clin North Am; 2009 Aug;42(4):635-54
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for vestibular schwannoma.
  • Since Leksell first treated a patient who had a vestibular schwannoma in 1967, there has been a year-to-year increase in the number of patients treated with the gamma knife for vestibular schwannoma.
  • This article outlines the technique of GKRS and discusses the current results of its use to treat vestibular schwannomas.
  • Other topics discussed include tumor control, treatment of recurrent/residual and cystic vestibular schwannomas, and the results of treatment of neurofibromatosis type 2.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiation Injuries / prevention & control. Radiosurgery / methods
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Invasiveness / pathology. Neoplasm Staging. Patient Selection. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Risk Assessment. Survival Analysis. Treatment Outcome

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19751869.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
  •  go-up   go-down


49. Tan M, Myrie OA, Lin FR, Niparko JK, Minor LB, Tamargo RJ, Francis HW: Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007. Laryngoscope; 2010 Jan;120(1):144-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007.
  • OBJECTIVES/HYPOTHESIS: To assess trends in the management of unilateral vestibular schwannomas over an 11-year period and to identify disease- and provider-related influences.
  • METHODS: Subjects presented to the Department of Otolaryngology-Head and Neck Surgery and the Department of Neurosurgery for management of unilateral vestibular schwannoma from 1997 through 2007, with at least two visits within the first year of presentation.
  • The proportion of patients for whom initial management consisted of observation, surgical resection, or radiation therapy was determined, and the relative influence of study year, patient age, hearing status, and tumor size was analyzed.
  • There were no changes in mean age or hearing status at diagnosis, but mean tumor size declined significantly.
  • Tumors that were surgically removed were on average 11.6 mm larger than those that were observed.
  • The increasing frequency over time of observation relative to surgery was significant even after controlling for age, hearing status, and tumor size.
  • CONCLUSIONS: Among patients managed by our center, there has been a significant shift in management of vestibular schwannomas over the last decade, with increasing tendency towards observation.
  • [MeSH-major] Ear Neoplasms / therapy. Neuroma, Acoustic / therapy

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19877188.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


50. Ferri GG, Modugno GC, Pirodda A, Fioravanti A, Calbucci F, Ceroni AR: Conservative management of vestibular schwannomas: an effective strategy. Laryngoscope; 2008 Jun;118(6):951-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of vestibular schwannomas: an effective strategy.
  • OBJECTIVES: Stimulated by the availability of a larger sample of patients and a longer follow-up period, we update our experience with conservative management of vestibular schwannomas.
  • STUDY DESIGN: Patients with intracanalicular and small/medium-sized tumors have been followed prospectively at a tertiary referral center.
  • METHODS: One hundred twenty-three patients affected by sporadic vestibular schwannoma were primarily observed by means of magnetic resonance imaging scans.
  • In case of significant tumor growth (> or =2 mm), patients were either surgically treated or submitted to radiotherapy, but, not rarely, they continued to follow the "wait-and-scan" policy.
  • Tumor-size changes over time were also evaluated with hearing function.
  • RESULTS: Almost two thirds (64.5%) of the cases did not show tumor growth during the entire period of observation (mean follow-up period, 4.8 yrs).
  • Among growing tumors, 16 patients were surgically treated with no complications or facial nerve palsy.
  • Less than half (45.5%) of the patients presented useful hearing (classes A and B of the American Academy of Otolaryngology-Head and Neck Surgery classification) at diagnosis, and 41 (73.2%) patients had preserved hearing during follow-up independently from the tumor growth rate.
  • CONCLUSIONS: Conservative management of vestibular schwannoma appears to be a safe procedure because most tumors do not grow and surgical outcomes are not affected by possible delays.
  • Because of the irregular behavior of the tumor, periodic neuroradiologic scans are mandatory to limit late surgical risks.
  • [MeSH-major] Ear Neoplasms / surgery. Neurilemmoma / surgery. Vestibule, Labyrinth

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18438269.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


51. Friedman WA: Linear accelerator radiosurgery for vestibular schwannomas. Prog Neurol Surg; 2008;21:228-37
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Linear accelerator radiosurgery for vestibular schwannomas.
  • The treatment paradigm uses the rotating high-energy X-ray output of the LINAC to focus many hundreds of 'beam equivalents' on intracranial or spinal targets.
  • At the University of Florida, 450 vestibular schwannomas have been treated.
  • Tumor control has been achieved in 90% (5- year actuarial data).
  • Since reducing the treatment dose to 1,250 cGy, in 1994, the incidence of facial and trigeminal nerve injury has been <1%.
  • No instance of malignant tumor transformation has been observed.
  • We believe that radiosurgery is the treatment of choice for smaller vestibular schwannomas.
  • [MeSH-major] Neuroma, Acoustic / surgery. Particle Accelerators / instrumentation. Radiosurgery / instrumentation

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18810224.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 22
  •  go-up   go-down


52. Stangerup SE, Thomsen J, Tos M, Cayé-Thomasen P: Long-term hearing preservation in vestibular schwannoma. Otol Neurotol; 2010 Feb;31(2):271-5
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term hearing preservation in vestibular schwannoma.
  • OBJECTIVE: The aim of the present study was to evaluate the long-term hearing during "wait and scan" management of vestibular schwannomas.
  • SUBJECTS: During a 33-year period, from 1976 to 2008, 1,144 patients with vestibular schwannoma were allocated to observation by the wait and scan policy, with annual magnetic resonance imaging and audiologic examination.
  • CONCLUSION: Most vestibular schwannoma patients with 100% speech discrimination at diagnosis maintain good hearing even after many years of observation.
  • [MeSH-major] Hearing Loss / etiology. Hearing Loss / prevention & control. Neuroma, Acoustic / complications. Neuroma, Acoustic / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Audiometry, Pure-Tone. Databases, Factual. Denmark / epidemiology. Disease Progression. Female. Hearing / physiology. Humans. Male. Middle Aged. Speech Perception. Young Adult

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19887973.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


53. Doherty JK, Friedman RA: Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg; 2006 Oct;14(5):305-13
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Controversies in building a management algorithm for vestibular schwannomas.
  • PURPOSE OF REVIEW: The present review examines the various mainstream treatment options, benefits and risks, and controversies involved in developing a management algorithm for treatment of vestibular schwannoma.
  • RECENT FINDINGS: Advances in microsurgery and radiosurgery have made tremendous contributions to management of vestibular schwannoma; however, considerable controversy still exists.
  • The auditory and facial nerve functional outcomes have improved with use of intraoperative monitoring for vestibular schwannoma removal and with lower radiosurgery doses; however, risks to the facial and auditory nerves still exist.
  • Observing vestibular schwannomas for growth with serial magnetic resonance imaging is an increasingly popular option for small vestibular schwannomas that allows patients to enjoy hearing and facial function.
  • SUMMARY: The risks and benefits of each treatment option must be weighed for each patient, and management decisions regarding vestibular schwannomas should be individualized for each patient depending on tumor anatomy, patient preferences, and symptoms.
  • [MeSH-major] Algorithms. Ear, Inner / surgery. Neuroma, Acoustic / therapy
  • [MeSH-minor] Cochlear Nerve / physiology. Facial Nerve / physiology. Hearing Loss / prevention & control. Humans. Magnetic Resonance Imaging. Microsurgery. Neurofibromatosis 2 / surgery. Neurofibromatosis 2 / therapy. Radiosurgery. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):297-8 [16974140.001]
  • (PMID = 16974142.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
  •  go-up   go-down


54. Welling DB, Packer MD, Chang LS: Molecular studies of vestibular schwannomas: a review. Curr Opin Otolaryngol Head Neck Surg; 2007 Oct;15(5):341-6
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular studies of vestibular schwannomas: a review.
  • PURPOSE OF REVIEW: To summarize advances in understanding the molecular biology of vestibular schwannomas over the past year.
  • RECENT FINDINGS: The role of the neurofibromatosis type 2 protein, denoted as merlin or schwannomin, in embryonic development, cellular adherence, and in cell proliferation has become better elucidated in the past year.
  • Likewise, the role of merlin in Schwann cell-axon interaction has been studied.
  • Neurofibromatosis type 2 screening guidelines for young patients with solitary vestibular schwannomas have been published.
  • The role of electromagnetic radiation via cellular and portable telephones as a predisposing factor to vestibular schwannoma formation has also been the topic of several studies.
  • [MeSH-major] Neuroma, Acoustic / genetics
  • [MeSH-minor] Animals. Cell Phones. Embryonic Development. Genetic Testing. Humans. Mutation. Neurofibromatosis 2 / genetics. Neurofibromin 2 / metabolism. Oligonucleotide Array Sequence Analysis

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17823551.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
  • [Number-of-references] 36
  •  go-up   go-down


55. Sahu RN, Behari S, Agarwal VK, Giri PJ, Jain VK: Taste dysfunction in vestibular schwannomas. Neurol India; 2008 Jan-Mar;56(1):42-6
MedlinePlus Health Information. consumer health - Taste and Smell Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Taste dysfunction in vestibular schwannomas.
  • BACKGROUND: Gustatory dysfunction associated with vestibular schwannomas (VS) is a poorly represented clinical presentation.
  • Preoperatively, taste disturbance was found in 29 (37.2%) giant, 28 (45.9%) large and one (33.3%) medium-sized tumors, respectively.
  • Among patients with anatomically preserved facial nerve, postoperative taste disturbances were found in 55 (42.3%) patients whereas nine (6.9%) patients reported improvement in taste sensations.
  • CONCLUSIONS: Taste dysfunction is common following vestibular schwannoma surgery.
  • Taste dysfunction should be included in the facial nerve functional grading system while assessing outcome.
  • [MeSH-major] Neuroma, Acoustic / complications. Taste Disorders / etiology

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18310836.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  •  go-up   go-down


56. Roche PH, Ribeiro T, Khalil M, Soumare O, Thomassin JM, Pellet W: Recurrence of vestibular schwannomas after surgery. Prog Neurol Surg; 2008;21:89-92
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of vestibular schwannomas after surgery.
  • The issue of recurrence of vestibular schwannomas is poorly studied by the surgical literature and is probably underestimated.
  • This long-term event is mainly due to regrowth of microfragments that have been left in the operative field along the course of the facial nerve or at the surface of the pons.
  • Management of recurrence depends on the tumor size and patient's condition.
  • Prospective long-term follow-up studies using serial MR imaging after radical removal should bring reliable data about the incidence of vestibular schwannoma recurrence.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Neuroma, Acoustic / surgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18810204.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 7
  •  go-up   go-down


57. Goddard JC, Oliver ER, Lambert PR: Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma. Otol Neurotol; 2010 Apr;31(3):473-7
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma.
  • OBJECTIVE: Evaluate the rate of cerebrospinal fluid (CSF) leak after translabyrinthine craniotomy for the removal of vestibular schwannoma and describe details of closure technique.
  • PATIENTS: All individuals undergoing translabyrinthine craniotomy for removal of vestibular schwannoma from January 2000 to October 2008.
  • INTERVENTION: Translabyrinthine craniotomy for removal of vestibular schwannoma with abdominal fat graft harvest and layered closure.
  • RESULTS: Sixty-one patients underwent translabyrinthine craniotomy for the removal of vestibular schwannoma during a 9-year period.
  • CONCLUSION: Successful wound closure and CSF leak prevention after translabyrinthine craniotomy for the removal of vestibular schwannomas do not require the creation of a facial recess, manipulation of the ossicles, direct Eustachian tube plugging, or the use of alloplastic space-occupying materials.
  • [MeSH-major] Cerebrospinal Fluid Otorrhea / prevention & control. Cerebrospinal Fluid Rhinorrhea / prevention & control. Craniotomy / adverse effects. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Vestibule, Labyrinth / surgery

  • Genetic Alliance. consumer health - Cerebrospinal Fluid Leak.
  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20084041.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


58. Samii M, Gerganov V, Samii A: Hearing preservation after complete microsurgical removal in vestibular schwannomas. Prog Neurol Surg; 2008;21:136-41
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation after complete microsurgical removal in vestibular schwannomas.
  • AIM: To evaluate and present the treatment strategy and hearing preservation in a recent series of vestibular schwannoma cases.
  • RESULTS: The anatomical integrity of the cochlear nerve was preserved in 75.8% of the cases.
  • It was highest in small tumors--60% in class T1 and 72% in class T2.
  • In tumors extending to and compressing the brain stem, preservation of some hearing was possible in up to 43%.
  • CONCLUSIONS: Vestibular schwannomas are benign lesions whose total removal leads to definitive healing of the patient.
  • Using the retrosigmoid approach with the patient in the semi-sitting position, hearing preservation is possible even for large schwannomas.
  • [MeSH-major] Hearing Loss / prevention & control. Microsurgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry. Cochlear Nerve / physiopathology. Cohort Studies. Humans. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18810211.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


59. Fukuda M, Oishi M, Kawaguchi T, Watanabe M, Takao T, Tanaka R, Fujii Y: Etiopathological factors related to hydrocephalus associated with vestibular schwannoma. Neurosurgery; 2007 Dec;61(6):1186-92; discussion 1192-3
MedlinePlus Health Information. consumer health - Hydrocephalus.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Etiopathological factors related to hydrocephalus associated with vestibular schwannoma.
  • OBJECTIVE: We retrospectively analyzed various clinical factors to determine whether or not these factors are etiopathologically related to the development of hydrocephalus in patients with vestibular schwannomas.
  • METHODS: There were 68 patients (29 men, 39 women) in this study who underwent resection of a vestibular schwannoma.
  • The maximum diameter of the tumor in the cerebellopontine cistern ranged from 0 (localized within the internal auditory canal) to 56 mm (mean, 32.0 +/- 12.9 mm).
  • Univariate analysis of various factors revealed that both tumor size and CSF protein concentration were positively related to development of hydrocephalus (P < 0.05 and P < 0.01, respectively).
  • There was a trend toward increased CSF protein concentration in patients with a large tumor (> or = 40 mm) compared with those with a small tumor (< 40 mm) (P = 0.06).
  • CONCLUSION: A high CSF protein concentration in fluid from the cerebellomedullary cistern is one of the most important factors contributing to hydrocephalus associated with vestibular schwannoma.
  • It is important to judge whether or not any further treatment is required for hydrocephalus, in addition to tumor resection, especially in patients with communicating hydrocephalus.
  • [MeSH-major] Brain Neoplasms / complications. Hydrocephalus / etiology. Hydrocephalus / pathology. Neuroma, Acoustic / complications


60. Yomo S, Arkha Y, Delsanti C, Roche PH, Thomassin JM, Régis J: Repeat gamma knife surgery for regrowth of vestibular schwannomas. Neurosurgery; 2009 Jan;64(1):48-54; discussion 54-5
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeat gamma knife surgery for regrowth of vestibular schwannomas.
  • OBJECTIVE: Gamma knife surgery (GKS) has become established as a minimally invasive treatment modality for patients with vestibular schwannomas.
  • Treatment failure and/or tumor regrowth, however, is occasionally encountered, and microsurgical resection is usually warranted in such cases.
  • The goal of this study was to investigate whether repeat GKS is an effective treatment for recurrent vestibular schwannomas and to assess the conservation of residual neurological function.
  • METHODS: Between July 1992 and December 2007, 1951 patients harboring a unilateral vestibular schwannoma were treated with GKS.
  • Of these, 48 patients (2.5%) had to undergo a subsequent intervention because of progression or regrowth of the tumor.
  • Repeat GKS was performed in a total of 15 patients, 8 of whom had more than 2 years of follow-up and were eligible to be enrolled in the present study.
  • The median tumor volume was 0.51 and 1.28 mL at the initial and second GKS treatments, respectively.
  • Six patients demonstrated a significant reduction in tumor volume.
  • In 1 patient, the final tumor volume was less than the initial volume.
  • The other 2 patients showed stabilization of tumor growth.
  • Neither aggravation of facial nerve dysfunction nor other neurological deficits secondary to GKS were observed.
  • CONCLUSION: This is the first report to address repeat GKS for vestibular schwannomas.
  • After long-term follow-up, repeat GKS with a low marginal dose seems to be a safe and effective treatment in selected patients harboring regrowth of small vestibular schwannomas that have previously been treated with GKS.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Radiosurgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19050660.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


61. Møller MN, Werther K, Nalla A, Stangerup SE, Thomsen J, Bøg-Hansen TC, Nielsen HJ, Cayé-Thomasen P: Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1. Laryngoscope; 2010 Apr;120(4):657-62
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1.
  • OBJECTIVES/HYPOTHESIS: Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis.
  • It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking.
  • This study targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1.
  • A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.
  • STUDY DESIGN: Prospective vestibular schwannoma tissue sampling for ELISA and immunohistochemical determination of MMP-2, MMP-9 and TIMP-1.
  • METHODS: Thirty-four patients with a sporadic, noncystic, vestibular schwannoma were selected prospectively.
  • Repeated, preoperative magnetic resonance imaging determined the tumor growth pattern.
  • Following translabyrinthine resection, an enzyme-linked immunosorbent assay was used for determination of the MMP-2, MMP-9, and TIMP-1 concentration in tumor sample homogenates.
  • Immunohistochemical labeling was performed in 12 randomly selected tumors.
  • RESULTS: : All tumor homogenates expressed measurable MMP-9, MMP-2, and TIMP-1.
  • Immunolabeling localized MMP-9 expression to the tumor cells, whereas MMP-2 and TIMP-1 was found interstitially.
  • A significant correlation existed between the concentration MMP-9 and absolute tumor growth rate, whereas a weak correlation occurred for the relative growth rate.
  • CONCLUSIONS: Vestibular schwannomas express MMP-2, MMP-9, and TIMP-1 and the tumor concentration of MMP-9 correlates with absolute tumor growth rate, but not with age, gender, symptom duration, or preoperative tumor size.
  • We conclude that MMP-9 appears to be involved in the growth of vestibular schwannomas.
  • [MeSH-major] Matrix Metalloproteinase 2 / biosynthesis. Matrix Metalloproteinase 9 / biosynthesis. Neovascularization, Pathologic / enzymology. Neuroma, Acoustic / blood supply. RNA, Neoplasm / genetics. Tissue Inhibitor of Metalloproteinase-1 / genetics
  • [MeSH-minor] Adult. Aged. Enzyme-Linked Immunosorbent Assay. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prospective Studies

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20205165.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
  •  go-up   go-down


62. Nicoucar K, Momjian S, Vader JP, De Tribolet N: Surgery for large vestibular schwannomas: how patients and surgeons perceive quality of life. J Neurosurg; 2006 Aug;105(2):205-12
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery for large vestibular schwannomas: how patients and surgeons perceive quality of life.
  • OBJECT: The aim of this study was to assess the consequences of total removal of a large vestibular schwannoma on the patient's symptoms and quality of life (QOL).
  • METHODS: A questionnaire regarding preoperative and postoperative symptoms with measures of both daily and global QOL and a modified 36-Item Short Form Health Survey (SF-36) QOL instrument were sent to 103 patients who had undergone surgery via a retrosigmoid approach for total removal of a Grade III or IV vestibular schwannoma.
  • Forty-six (64%) of the schwannomas were Grade IV and 26 (36%) were Grade III.
  • Patients with large vestibular schwannomas had lower scores in all SF-36 categories except pain compared with data from other studies.
  • CONCLUSIONS: Surgery for a large vestibular schwannoma has a significant impact on the patient's QOL.
  • [MeSH-major] Attitude of Health Personnel. Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life / psychology

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17219824.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


63. Mick P, Westerberg BD, Ngo R, Akagami R: Growing vestibular schwannomas: what happens next? Otol Neurotol; 2009 Jan;30(1):101-4
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growing vestibular schwannomas: what happens next?
  • OBJECTIVE: To determine the subsequent growth patterns in vestibular schwannomas shown to be growing on serial imaging.
  • PATIENTS: Patients with tumors that demonstrated growth of greater than 1 mm/yr between 2 consecutive scans (magnetic resonance or computed tomography) and had at least 1 follow-up scan were included.
  • MAIN OUTCOME MEASURE(S): Maximum dimension along the axis of the internal auditory canal was measured for intracanalicular tumors, whereas for extracanalicular tumors, maximal dimension along any orientation was used.
  • Of the growing tumors, 63.9% continued to grow, 30.6% stayed the same size, and 5.6% regressed in size.
  • CONCLUSION: Most vestibular schwannomas identified to be growing are likely to continue to grow on subsequent serial imaging.
  • These results are useful in clinical decision making and counseling patients with growing vestibular schwannomas.
  • [MeSH-major] Neuroma, Acoustic / pathology
  • [MeSH-minor] Cell Division. Ear Canal / pathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Patient Selection. Remission, Spontaneous. Tomography, X-Ray Computed

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19108071.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


64. Lavrova SA, Leshchinskiĭ VG, Shershever AS, Iazov OA, Gerasimov MV: [Predictive value of intraoperative monitoring of brainstem acoustic evoked potentials during removal of parabrainstem tumors]. Zh Vopr Neirokhir Im N N Burdenko; 2005 Apr-Jun;(2):8-12; discussion 12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Predictive value of intraoperative monitoring of brainstem acoustic evoked potentials during removal of parabrainstem tumors].
  • The data of intraoperative monitoring of brainstem acoustic evoked potentialities (BAEP) during parabrainstem tumors are analyzed.
  • Of the 24 cases, 16 patients were found to have neurinoma of the acoustic nerve, 4 had petroclival meningioma, 2, tentorial meningioma, 1, cholesteatoma of the cerebellopontine angle, and 1, brainstem angioma.
  • The authors proposed to identify the favorable and unfavorable patterns of BAEP as predictors of an early postoperative period, by comparing the patterns of BAEP, the data on the monitoring vital functions and outcomes of disease.
  • By taking into account the high coincidence of actual and predictable outcomes (79.16%), it can be suggested that the data of intraoperative monitoring of BAEP are not only of value for obtaining information at the moment of surgery, but also informative as a predictor of an early postoperative period and outcomes of disease.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Evoked Potentials, Auditory, Brain Stem. Monitoring, Intraoperative / methods

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16078627.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  •  go-up   go-down


65. Koerbel A, Gharabaghi A, Safavi-Abbasi S, Tatagiba M, Samii M: Evolution of vestibular schwannoma surgery: the long journey to current success. Neurosurg Focus; 2005 Apr 15;18(4):e10
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evolution of vestibular schwannoma surgery: the long journey to current success.
  • The extraordinary improvement of patient outcome after surgical treatment for vestibular schwannomas is relatively recent and has occurred mainly over the last 30 years.
  • Whereas in the past the primary goal of vestibular schwannoma management was to preserve the patient's life, the objective in vestibular schwannoma treatment today is to preserve neurological function.
  • Long-term follow-up examinations show negligible recurrence rates, indicating that the aim of preservation of nerve function does not limit the completeness of tumor removal with modern neurosurgical techniques.
  • Despite these advances in preserving the anatomical integrity of, for example, the cochlear nerve, losses of function and even deafness may occur postoperatively in some cases.
  • In this article, the authors report in detail the developments achieved in vestibular schwannoma surgery and the great clinicians to whom these results can be credited.
  • [MeSH-major] Microsurgery / history. Neuroma, Acoustic / history. Neuroma, Acoustic / surgery. Neurosurgery / history. Neurosurgical Procedures / history. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Deafness / etiology. Deafness / prevention & control. Facial Nerve Injuries / etiology. Facial Nerve Injuries / prevention & control. History, 18th Century. History, 19th Century. History, 20th Century. Humans. Neoplasm Recurrence, Local / prevention & control. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / prevention & control. Vestibulocochlear Nerve Injuries

  • Genetic Alliance. consumer health - Schwannoma.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15844862.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
  •  go-up   go-down


66. Sabol Z, Kipke-Sabol L, Miklić P, Hajnsek-Propadalo S, Sabol F: [Neurofibromatosis type 2 (central neurofibromatosis or bilateral acoustic neuromas, vestibular schwannomas): from phenotype to gene]. Lijec Vjesn; 2006 Sep-Oct;128(9-10):309-16
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Neurofibromatosis type 2 (central neurofibromatosis or bilateral acoustic neuromas, vestibular schwannomas): from phenotype to gene].
  • Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that predisposes to bilateral vestibular schwannomas (neurinomas), other central and peripheral nervous system tumours (multiple meningeomas and neurofibromas) and ocular abnormalities (cataract).
  • NF2 has a variable clinical presentation, with two basic types: severe type having early onset and progressive growth of tumors and the milder type having later onset and less aggressive course.
  • The genotype-phenotype correlations indicate a greater variability of clinical disease expression.
  • [MeSH-major] Neurofibromatosis 2 / genetics. Neuroma, Acoustic / genetics


67. Mohammed TA, Ahuja MS, Ju SS, Thomas J: Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma. J Postgrad Med; 2010 Jul-Sep;56(3):213-5
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma.
  • Vestibular schwannomas are not uncommon, and gamma knife radiosurgery is one of the treatment options for symptomatic tumors.
  • Hydrocephalus is a complication of gamma knife treatment of vestibular schwannoma, though the mechanism of the development of hydrocephalus remains controversial.
  • We present an unusual case of normal pressure hydrocephalus (NPH) after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of the hydrocephalus.
  • [MeSH-major] Hydrocephalus, Normal Pressure / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


68. Fukuoka S, Takanashi M, Hojyo A, Konishi M, Tanaka C, Nakamura H: Gamma knife radiosurgery for vestibular schwannomas. Prog Neurol Surg; 2009;22:45-62
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for vestibular schwannomas.
  • The purpose of this study was to analyze tumor control and possible complications of gamma knife radiosurgery (GKRS) in patients with vestibular schwannomas using low marginal doses and conformal multiple shots to fit irregular tumor shapes.
  • The actuarial tumor control rates were 94% at 5 years and 92.4% at 8 years.
  • Larger tumors (p < 0.0001) and those in younger patients (p = 0.018) tended to recur significantly more often.
  • Fifty-six other patients not included in the long-term evaluation consecutively underwent caloric testing and static stabilometry as well as neurological examinations to evaluate vestibular function in detail, both before and after GKRS.
  • The results revealed 90% of the patients to have already developed vestibular dysfunction prior to the treatment despite reported symptoms of dizziness.
  • GKRS did not significantly affect vestibular function.
  • Hydrocephalus was recognized in 5.3% of all patients, and tended to occur in cases with larger tumors (p = 0.0024).
  • GKRS provides a safe and effective therapy for small to medium-sized tumors.
  • However, indications for larger tumors must be carefully considered, as they are more difficult to control and liable to produce ataxia due to transient expansion.
  • [MeSH-major] Hearing. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve / physiology. Female. Follow-Up Studies. Humans. Hydrocephalus / diagnosis. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / diagnosis. Radiation Dosage. Tomography, Emission-Computed, Single-Photon. Treatment Outcome. Trigeminal Nerve / physiology. Vestibular Nerve / physiology. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18948719.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  •  go-up   go-down


69. Lassaletta L, Bello MJ, Del Río L, Alfonso C, Roda JM, Rey JA, Gavilan J: DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings. Otol Neurotol; 2006 Dec;27(8):1180-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings.
  • HYPOTHESIS: The purpose of this study was to examine the DNA methylation profile of several genes in a series of vestibular schwannomas, and to analyze its relationship with clinical and radiological features.
  • BACKGROUND: Aberrant methylation of promoter regions is a major mechanism for silencing of tumor suppressor genes in several tumors.
  • There is limited information about methylation status in vestibular schwannoma, with no clinical or radiological implications described to date.
  • METHODS: The methylation status of 16 tumor-related genes including RASSF1A, RAR-B, VHL, PTEN, HMLH1, RB1, TP16, CASP8, ER, TIMP3, MGMT, DAPK, TP73, GSTP1, TP14, and THBS1 was examined in a series of 22 vestibular schwannomas.The bisulfite modification of genomic DNA was performed.
  • Methylation of CASP8 was associated with the patient's age and the tumor size.
  • CONCLUSION: Aberrant methylation of tumor-related genes may play a role in the development of vestibular schwannomas.
  • Our results may provide useful clues to the development of prognostic assays for these tumors.
  • [MeSH-major] DNA Methylation. Neuroma, Acoustic / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Auditory Threshold / physiology. Female. Genes, Tumor Suppressor / physiology. Hearing Loss / genetics. Humans. Male. Middle Aged. Promoter Regions, Genetic / genetics


70. Chen L, Chen LH, Ling F, Liu YS, Samii M, Samii A: Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy. Chin Med J (Engl); 2010 Feb 5;123(3):274-80
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy.
  • BACKGROUND: Vestibular schwannoma, the commonest form of intracranial schwannoma, arises from the Schwann cells investing the vestibular nerve.
  • At present, the surgery for vestibular schwannoma remains one of the most complicated operations demanding for surgical skills in neurosurgery.
  • And the trend of minimal invasion should also be the major influence on the management of patients with vestibular schwannomas.
  • We summarized the microsurgical removal experience in a recent series of vestibular schwannomas and presented the operative technique and cranial nerve preservation in order to improve the rates of total tumor removal and facial nerve preservation.
  • METHODS: A retrospective analysis was performed in 145 patients over a 7-year period who suffered from vestibular schwannomas that had been microsurgically removed by suboccipital retrosigmoid transmeatus approach with small craniotomy.
  • CT thinner scans revealed the tumor size in the internal auditory meatus and the relationship of the posterior wall of the internal acoustic meatus to the bone labyrinths preoperatively.
  • Brain stem evoked potential was monitored intraoperatively.
  • The posterior wall of the internal acoustic meatus was designedly drilled off.
  • RESULTS: Total tumor resection was achieved in 140 cases (96.6%) and subtotal resection in 5 cases.
  • The anatomical integrity of the facial nerve was preserved in 91.0% (132/145) of the cases.
  • Intracranial end-to-end anastomosis of the facial nerve was performed in 7 cases.
  • Functional preservation of the facial nerve was achieved in 115 patients (Grade I and Grade II, 79.3%).
  • Preservation of nerves and vessels were as important as tumor removal during the operation.
  • CT thinner scan could show the relationship between the posterior wall of the internal acoustic meatus and bone labyrinths, that is helpful for a safe drilling of the posterior wall of the internal acoustic meatus.
  • Using the retrosigmoid approach with small craniotomy is possible even for large schwannomas.
  • Knowing the microanatomy of the cerebellopontine angle and internal auditory meatus, intraoperating neurophysiological monitoring of the facial nerve function, and the microsurgical techniques of the surgeons are all important factors for improving total tumor removal and preserving facial nerve function.
  • [MeSH-major] Craniotomy / methods. Facial Nerve / surgery. Neuroma, Acoustic / surgery

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20193244.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  •  go-up   go-down


71. Slattery WH 3rd: Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas. Otolaryngol Clin North Am; 2009 Aug;42(4):707-15
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas.
  • Radiosurgery or radiotherapy for vestibular schwannomas has become a common practice with a high chance for tumor control.
  • Despite the high rate of tumor control, there are some tumors that cannot be controlled with radiation therapy.
  • Surgical treatment after radiosurgery or radiotherapy may be necessary for tumors that continue to grow, or for patients who develop brainstem compressive symptoms, disabling hemifacial spasm, or hydrocephalus.
  • The House Ear Clinic (Los Angeles, California) experience with microsurgery after irradiation has demonstrated that the facial nerve is different once it has been radiated.
  • An irradiated facial nerve's regeneration potential is diminished, and the recovery from microsurgical trauma is not as robust.
  • [MeSH-major] Microsurgery / methods. Neoplasm Invasiveness / pathology. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Combined Modality Therapy. Cranial Irradiation / methods. Dose-Response Relationship, Radiation. Female. Humans. Male. Neoadjuvant Therapy. Neoplasm Staging. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Prognosis. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Risk Assessment. Survival Analysis. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19751874.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
  •  go-up   go-down


72. Conley GS, Hirsch BE: Stereotactic radiation treatment of vestibular schwannoma: indications, limitations, and outcomes. Curr Opin Otolaryngol Head Neck Surg; 2010 Oct;18(5):351-6
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiation treatment of vestibular schwannoma: indications, limitations, and outcomes.
  • PURPOSE OF REVIEW: Stereotactic radiation treatment is an increasingly performed procedure for patients with vestibular schwannoma and other benign skull base tumors.
  • The specific role of radiation in current management strategies for vestibular schwannoma continues to evolve as long-term outcome data are analyzed and standardized studies are performed.
  • Observation of small vestibular schwannomas is recommended over early radiation or microsurgical intervention.
  • Radiation may be used as adjunctive therapy for large tumors and in certain postradiation treatment failures.
  • Current evidence supports its use for small to medium sized primary and recurrent vestibular schwannomas with optimal dosing below 13 Gy.
  • It is also recommended for adjunctive therapy, recurrent tumors, in poor surgical candidates, and for those who do not desire observation or surgery.
  • [MeSH-major] Neuroma, Acoustic / radiotherapy. Radiosurgery. Skull Base Neoplasms / radiotherapy

  • Genetic Alliance. consumer health - Schwannoma.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20613529.001).
  • [ISSN] 1531-6998
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  •  go-up   go-down


73. Strauss C, Prell J, Rampp S, Romstöck J: Split facial nerve course in vestibular schwannomas. J Neurosurg; 2006 Nov;105(5):698-705
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Split facial nerve course in vestibular schwannomas.
  • OBJECT: The facial nerve in vestibular schwannomas (VSs) is located on the ventral tumor surface in more than 90% of cases; other courses are rare.
  • A split facial nerve course with two distinct bundles has thus far been described exclusively for medial extrameatal tumors.
  • METHODS: Between 1996 and 2005, 16 consecutive cases of 241 surgically treated VSs were observed to have distinct splitting of the facial nerve.
  • The mean tumor size measured 27 mm.
  • In one third of the cases, intrameatal tumor extension with obliteration of the fundus was documented.
  • In all 16 patients, distinct splitting of the facial nerve was demonstrated.
  • The major portion of the facial nerve followed a typical course on the ventral tumor surface.
  • The smaller nerve portion in all cases ran parallel to the brainstem up to the level of the trigeminal root exit zone and crossed on the cranial tumor pole to the internal auditory canal.
  • The two nerve portions rejoined at the level of the porus acusticus.
  • The smaller portion carried fibers exclusively to the orbicularis oris muscle, whereas the major portion supplied all three branches of the facial nerve.
  • CONCLUSIONS: In VSs, an aberrant course with distinct splitting of the facial nerve adds considerably to the surgical challenge.
  • Long-term facial nerve results are excellent with extensive neurophysiological monitoring, which allows the differentiation and identification of aberrant facial nerve fibers and avoids additional risks to facial nerve preservation.
  • [MeSH-major] Facial Nerve / pathology. Facial Nerve / physiopathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Adult. Aged. Cochlear Nerve / physiopathology. Cohort Studies. Electromyography. Facial Muscles / physiopathology. Female. Humans. Male. Middle Aged. Monitoring, Intraoperative. Treatment Outcome

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17121130.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


74. Jain VK, Mehrotra N, Sahu RN, Behari S, Banerji D, Chhabra DK: Surgery of vestibular schwannomas: an institutional experience. Neurol India; 2005 Mar;53(1):41-5; discussion 45
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery of vestibular schwannomas: an institutional experience.
  • AIMS: To report management results of vestibular schwannomas (VS) treated surgically in our institute, with particular reference to completeness of tumor excision, facial nerve and hearing preservation and complications of surgery.
  • MATERIALS AND METHODS: The facial nerve function and hearing assessment was done according to House-Brackmann [HB] grading and pure tone audiometry (PTA) respectively.
  • RESULTS: Most patients had large tumors and had no useful hearing (90%), had disabling cerebellar ataxia (88%) and presented with features of raised intra-cranial pressure (45%).
  • Large sized tumors were in 41.3% and giant sized tumors were in 56% cases.
  • Complete tumor excision was carried out in 96.5% and anatomical preservation of facial nerve was achieved in 79.2% cases.
  • Cerebrospinal fluid leak with or without meningitis and transient lower cranial nerve paresis were common complications.
  • CONCLUSIONS: With experience, complete tumor excision with good facial nerve preservation can be achieved in large tumors.
  • Hearing preservation is difficult in bigger tumors.
  • [MeSH-major] Facial Nerve / physiology. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Postoperative Complications

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15805654.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  •  go-up   go-down


75. Silk PS, Lane JI, Driscoll CL: Surgical approaches to vestibular schwannomas: what the radiologist needs to know. Radiographics; 2009 Nov;29(7):1955-70
MedlinePlus Health Information. consumer health - MRI Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches to vestibular schwannomas: what the radiologist needs to know.
  • Vestibular schwannomas account for 85% of cerebellopontine angle tumors in adults and most commonly arise from the inferior division of the vestibular nerve.
  • Three main surgical techniques are currently being used for the removal of vestibular schwannomas: middle cranial fossa, suboccipital, and translabyrinthine approaches.
  • A good understanding of the main surgical approaches, relevant anatomic considerations, surgical complications, and likelihood of tumor recurrence is essential for interpreting magnetic resonance images to the advantage of both the surgeon and the patient, particularly when hearing preservation is a consideration.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods. Surgery, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - CT Scans.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19926756.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


76. Huang CF, Tu HT, Lo HK, Wang KL, Liu WS: Radiosurgery for vestibular schwannomas. J Chin Med Assoc; 2005 Jul;68(7):315-20
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for vestibular schwannomas.
  • We report our experience with radiosurgery for tumor control and the complications of unilateral vestibular schwannomas.
  • METHODS: We reviewed our early experience regarding clinical presentation, management and outcomes in 45 patients with acoustic schwannomas who underwent gamma knife stereotactic radiosurgery.
  • Median tumor volume was 4.5 mL (range, 0.5-30.0), and median radiotherapy dose was 11.5 Gy (range, 10.5-14.0 Gy).
  • RESULTS: Tumor control was achieved in 43 patients (95.6%).
  • Reduction in tumor size was shown in 15 patients (33.3%).
  • No patients had delayed facial palsy or lower cranial nerve dysfunction, but one had delayed trigeminal sensory loss.
  • CONCLUSION: Radiosurgery achieved a high tumor control rate and a relatively low post-radiosurgical complication rate for acoustic neuromas.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16038371.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
  •  go-up   go-down


77. Gharabaghi A, Samii A, Koerbel A, Rosahl SK, Tatagiba M, Samii M: Preservation of function in vestibular schwannoma surgery. Neurosurgery; 2007 Feb;60(2 Suppl 1):ONS124-7; discussion ONS127-8
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preservation of function in vestibular schwannoma surgery.
  • The management and surgical technique for microsurgical tumor removal of vestibular schwannomas (acoustic neuroma) with the suboccipital retrosigmoid approach and semi-sitting patient positioning is described.
  • An emphasis is placed on the preservation of auditory and facial nerve function with a stepwise description of the technical and operative nuances, including presurgical evaluation, positioning, anesthesiological and neurophysiological aspects, approach, microsurgical techniques, and postsurgical care.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Otologic Surgical Procedures / methods

  • Genetic Alliance. consumer health - Schwannoma.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17297374.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
  •  go-up   go-down


78. Mandl ES, Vandertop WP, Meijer OW, Peerdeman SM: Imaging-documented repeated intratumoral hemorrhage in vestibular schwannoma: a case report. Acta Neurochir (Wien); 2009 Oct;151(10):1325-7
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging-documented repeated intratumoral hemorrhage in vestibular schwannoma: a case report.
  • Intratumoral hemorrhage in vestibular schwannomas is rare.
  • Intratumoral hemorrhage is probably caused by vascular fragility associated with tumor characteristics and growth.
  • The present report details the case of acute neurological deterioration in a patient with repeated intratumoral hemorrhage inside a vestibular schwannoma with computed tomography and magnetic resonance imaging confirmation.
  • To our knowledge, repeated hemorrhage in vestibular schwannoma with radiological confirmation has not been reported before.
  • [MeSH-major] Cerebellopontine Angle / pathology. Intracranial Hemorrhages / diagnosis. Intracranial Hemorrhages / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Vestibular Nerve / pathology
  • [MeSH-minor] Disease Progression. Facial Nerve Injuries / etiology. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / pathology. Hydrocephalus / surgery. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Postoperative Complications. Radiotherapy. Tomography, X-Ray Computed. Treatment Outcome. Ventriculoperitoneal Shunt

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Neurosurgery. 2003 Aug;53(2):282-87; discussion 287-8 [12925242.001]
  • [Cites] Clin Neurol Neurosurg. 1998 Mar;100(1):68-74 [9637211.001]
  • [Cites] Clin Radiol. 1994 Jan;49(1):61-3 [8299336.001]
  • [Cites] Neurol Med Chir (Tokyo). 1989 Apr;29(4):328-32 [2478916.001]
  • (PMID = 19255715.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Other-IDs] NLM/ PMC2760714
  •  go-up   go-down


79. Cauley KA, Ratkovits B, Braff SP, Linnell G: Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study. AJNR Am J Neuroradiol; 2009 May;30(5):992-4
MedlinePlus Health Information. consumer health - MRI Scans.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study.
  • Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors.
  • Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause hydrocephalus without treatment.
  • We present an MR imaging study of an unusual case of communicating hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of hydrocephalus.
  • [MeSH-major] Hydrocephalus / etiology. Hydrocephalus / pathology. Magnetic Resonance Imaging / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


80. Kramer F, Stöver T, Warnecke A, Diensthuber M, Lenarz T, Wissel K: BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. J Neurooncol; 2010 May;98(1):31-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity.
  • The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves.
  • Vestibular schwannoma arising from Schwann cells of the vestibular nerve are mostly benign and slow-growing.
  • Most of the pathogenic mechanisms regulating the vestibular schwannoma growth process are unknown.
  • However, molecular mechanisms interfering with regulation of the vestibular schwannoma growth also modulated by mitogenic factors have to be identified.
  • Neurotrophic factors are involved in regulation of developmental processes in neuronal tissues and regeneration after peripheral nerve trauma and also reveal mitogenic effects on glial cell populations.
  • Gene expression profiles of artemin, BDNF, GDNF, TGF-beta1/beta2 and Ret were determined in the vestibular schwannoma in comparison to the peripheral nerve tissues by using semiquantitative RT-PCR.
  • A significant higher BDNF expression was observed in the vestibular schwannoma, whereas gene expression of artemin and GDNF was upregulated in peripheral nerves.
  • The correlation between LI and BDNF, TGF-beta1 and Ret was found to be significant in the vestibular schwannoma.
  • Our results demonstrate a coherence between BDNF expression and proliferative activity in the vestibular schwannoma.
  • Based on these results, we propose a pivotal role for BDNF in modulating the vestibular schwannoma growth.
  • [MeSH-major] Brain-Derived Neurotrophic Factor / genetics. Cell Proliferation. Gene Expression Regulation, Neoplastic / physiology. Neuroma, Acoustic / genetics. RNA, Messenger / metabolism. Up-Regulation / physiology
  • [MeSH-minor] Adult. Aged. Female. Glial Cell Line-Derived Neurotrophic Factor / genetics. Glial Cell Line-Derived Neurotrophic Factor / metabolism. Humans. Ki-67 Antigen / metabolism. Male. Middle Aged. Nerve Tissue Proteins / genetics. Nerve Tissue Proteins / metabolism. Peripheral Nerves / metabolism. Statistics as Topic / methods. Statistics, Nonparametric. Transforming Growth Factor beta1 / genetics. Transforming Growth Factor beta1 / metabolism. Transforming Growth Factor beta2 / genetics. Transforming Growth Factor beta2 / metabolism. Young Adult

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19937367.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARTN protein, human; 0 / Brain-Derived Neurotrophic Factor; 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Ki-67 Antigen; 0 / Nerve Tissue Proteins; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1; 0 / Transforming Growth Factor beta2
  •  go-up   go-down


81. Schoemaker MJ, Swerdlow AJ, Auvinen A, Christensen HC, Feychting M, Johansen C, Klaeboe L, Lönn S, Salminen T, Tynes T: Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. Int J Cancer; 2007 Jan 1;120(1):103-10
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study.
  • Acoustic neuroma (vestibular schwannoma) is a benign tumor of the vestibulocochlear nerve.
  • Its recorded incidence is increasing but risk factors for this tumor have scarcely been investigated.
  • We conducted a population-based case-control study of risk factors for acoustic neuroma in the UK and Nordic countries, including 563 cases and 2,703 controls.
  • Tumor risk was analyzed in relation to medical history and cigarette smoking.
  • Risk of acoustic neuroma was significantly raised in parous compared with nulliparous women (OR = 1.7, 95% CI: 1.1-2.6), but was not related to age at first birth or number of children.
  • Risk was not associated with a history of allergic disease, past head injury, past diagnosis of a neoplasm or birth characteristics, but was significantly raised for past diagnosis of epilepsy (OR = 2.5, 95% CI: 1.3-4.9).
  • Tumor risk was significantly reduced in subjects who had ever regularly smoked cigarettes (OR = 0.7, 95% CI: 0.6-0.9), but the reduction applied only to current smokers (OR = 0.5, 95% CI: 0.4-0.6), not ex-smokers (OR = 1.0, 95% CI: 0.8-1.3).
  • The reduced risk of acoustic neuroma in smokers and raised risk in parous women might relate to sex hormone levels, or smoking might suppress tumor growth, but effects of parity and smoking on timing of diagnosis of the tumor are also a potential explanation.
  • The raised risk in relation to past diagnosis of epilepsy might be a surveillance artefact or imply that epilepsy and/or antiepileptic medication use predispose to acoustic neuroma.
  • [MeSH-major] Neuroma, Acoustic / etiology. Smoking / adverse effects


82. Ciric I, Zhao JC, Rosenblatt S, Wiet R, O'Shaughnessy B: Suboccipital retrosigmoid approach for removal of vestibular schwannomas: facial nerve function and hearing preservation. Neurosurgery; 2005 Mar;56(3):560-70; discussion 560-70
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Suboccipital retrosigmoid approach for removal of vestibular schwannomas: facial nerve function and hearing preservation.
  • In this report, we discuss the pertinent bony, arachnoid, and neurovascular anatomy of vestibular schwannomas that has an impact on the surgical technique for removal of these tumors, with the goal of facial nerve and hearing preservation.
  • The surgical technique is described in detail starting with anesthesia, positioning, and neurophysiological monitoring and continuing with the exposure, technical nuances of tumor removal, hemostasis, and closure.
  • [MeSH-major] Facial Nerve Injuries / prevention & control. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control
  • [MeSH-minor] Anesthesia, General. Arachnoid / anatomy & histology. Cochlear Nerve / anatomy & histology. Dura Mater / surgery. Electromyography. Endolymphatic Duct / anatomy & histology. Evoked Potentials, Auditory, Brain Stem. Facial Nerve / anatomy & histology. Humans. Mastoid / anatomy & histology. Monitoring, Intraoperative. Neurosurgical Procedures / methods. Prognosis. Semicircular Canals / anatomy & histology

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - After Surgery.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15730582.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
  •  go-up   go-down


83. Sughrue ME, Yang I, Rutkowski MJ, Aranda D, Parsa AT: Preservation of facial nerve function after resection of vestibular schwannoma. Br J Neurosurg; 2010 Dec;24(6):666-71
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Preservation of facial nerve function after resection of vestibular schwannoma.
  • OBJECTIVE: Most data regarding facial nerve function in patients undergoing microsurgical resection of vestibular schwannomas predominantly include series performed at a single institution.
  • In an effort to minimise individual surgeon or institutional bias, we performed an analysis of the published literature on facial nerve outcomes following microsurgical resection of vestibular schwannomas.
  • The objective of this study was to provide a comprehensive assessment of reported outcomes for facial nerve preservation after VS surgery.
  • MATERIALS AND METHODS: We identified a total of 296 studies involving over 25,000 patients that included outcome data for facial nerve function of vestibular schwannoma patients treated surgically.
  • Data regarding surgical approach, tumour size, patient age, and use of intra-operative monitoring were extracted and correlated with facial nerve function after surgery.
  • Patients with preoperative facial nerve dysfunction (House-Brackmann score 3 or higher) were excluded and 'facial nerve preservation' was defined as grade I or II House-Brackmann function at last follow-up visit.
  • Patients treated with the middle cranial fossa approach had a trend towards higher overall facial nerve preservation rate (85%), compared to the translabyrinthine approach (81%, p = 0.07) , and did statistically better than the retrosigmoid approach (78%, p < 0.0001).
  • Patients with an average tumour size <20 mm had significantly improved facial nerve preservation rates, compared to larger tumours (90% vs. 67%, p < 0.0001).
  • Patients under 65 years of age had a lower facial nerve preservation rate (71% vs. 84%, p < 0.001).
  • Finally, the use of intra-operative monitoring improved the facial nerve preservation rate (76% vs. 71%, p < 0.001).
  • CONCLUSION: Factors that appear to be associated with facial nerve preservation after microsurgical resection of a vestibular schwannoma include tumour size <20 mm, use of the middle fossa approach and use of neuromonitoring during surgery.
  • These data provide a summary assessment of the published literature regarding facial nerve preservation after microsurgical resection of vestibular schwannoma.
  • [MeSH-major] Facial Nerve / physiopathology. Facial Nerve Injuries / prevention & control. Neuroma, Acoustic / physiopathology. Radiation Injuries / prevention & control. Radiosurgery / methods

  • Genetic Alliance. consumer health - Schwannoma.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21070151.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  •  go-up   go-down


84. Khrais T, Romano G, Sanna M: Nerve origin of vestibular schwannoma: a prospective study. J Laryngol Otol; 2008 Feb;122(2):128-31
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nerve origin of vestibular schwannoma: a prospective study.
  • OBJECTIVE: The origin of vestibular schwannoma has always been a matter of debate.
  • The aim of our study was to identify the nerve origin of this tumour.
  • METHODS: A total of 200 cases of vestibular schwannoma were included in the study.
  • The origin of the tumour was limited to one nerve at the fundus in 152 cases (76 per cent).
  • Out of these cases, the tumour originated from the inferior vestibular nerve in 139 cases (91.4 per cent), from the superior vestibular nerve in nine cases (6 per cent), from the cochlear nerve in two cases (1.3 per cent) and from the facial nerve in two cases (1.3 per cent).
  • CONCLUSION: The vast majority of vestibular schwannomas originate from the inferior vestibular nerve; the incidence of involvement of this nerve increases as the tumour size increases.
  • An origin of vestibular schwannoma from the inferior vestibular nerve can be considered as one of the explanatory factors for the poor functional outcome of the extended middle cranial fossa approach, and probably accounts also for the better hearing preservation rate reported in some series for the retrosigmoid approach.
  • [MeSH-major] Neuroma, Acoustic / pathology. Otologic Surgical Procedures / methods. Vestibular Nerve / pathology
  • [MeSH-minor] Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Prospective Studies

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18039415.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


85. Neff BA, Welling DB, Akhmametyeva E, Chang LS: The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level. Otol Neurotol; 2006 Feb;27(2):197-208
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level.
  • OBJECTIVE: The goal of this article was to review concisely what is currently known about the tumorigenesis of vestibular schwannomas.
  • BACKGROUND: Recent advances in molecular biology have led to a better understanding of the cause of vestibular schwannomas.
  • Mutations in the neurofibromatosis type 2 tumor suppressor gene (NF2) have been identified in these tumors.
  • In addition, the interactions of merlin, the protein product of the NF2 gene, and other cellular proteins are beginning to give us a better idea of NF2 function and the pathogenesis of vestibular schwannomas.
  • RESULTS: The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 syndromes are reviewed and related to alterations in the NF2 gene.
  • Studies demonstrating our current understanding of tumor developmental pathways are highlighted.
  • In addition, methods of clinical and genetic screening for neurofibromatosis type 2 disease are outlined.
  • CONCLUSION: Great strides have been made to identify why vestibular schwannomas develop at the molecular level.
  • Continued research is needed to find targeted therapies with which to treat these tumors.
  • [MeSH-major] Chromosomes, Human, Pair 22. Genes, Neurofibromatosis 2. Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Alternative Splicing. Animals. Disease Models, Animal. Genetic Testing. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Mice. Promoter Regions, Genetic. RNA, Messenger / genetics. Signal Transduction / genetics

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16436990.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2; 0 / RNA, Messenger
  • [Number-of-references] 114
  •  go-up   go-down


86. Sughrue ME, Yang I, Han SJ, Aranda D, Kane AJ, Amoils M, Smith ZA, Parsa AT: Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannoma. Neurosurg Focus; 2009 Dec;27(6):E4
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Non-audiofacial morbidity after Gamma Knife surgery for vestibular schwannoma.
  • OBJECT: While many studies have been published outlining morbidity following radiosurgical treatment of vestibular schwannomas, significant interpractitioner and institutional variability still exists.
  • For this reason, the authors conducted a systematic review of the literature for non-audiofacial-related morbidity after the treatment of vestibular schwannoma with radiosurgery.
  • METHODS: The authors performed a comprehensive search of the English-language literature to identify studies that published outcome data of patients undergoing radiosurgery treatment for vestibular schwannomas.
  • All tumors included in this study were < 25 mm in their largest diameter.
  • Patients receiving > 13 Gy were significantly more likely to develop trigeminal nerve neuropathy than those receiving < 13 Gy (p < 0.001).
  • CONCLUSIONS: The results of our review of the literature provide a systematic summary of the published rates of nonaudiofacial morbidity following radiosurgery for vestibular schwannoma.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Cranial Nerve Diseases / epidemiology. Cranial Nerve Diseases / etiology. Humans. Hydrocephalus / epidemiology. Hydrocephalus / etiology. Hydrocephalus / surgery. Postoperative Complications / epidemiology. Postoperative Complications / etiology. Postoperative Complications / mortality. Radiation Dosage. Radiotherapy Dosage / standards. Tinnitus / epidemiology. Tinnitus / etiology. Treatment Outcome. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / etiology. Trigeminal Neuralgia / epidemiology. Trigeminal Neuralgia / etiology. Vertigo / epidemiology. Vertigo / etiology

  • Genetic Alliance. consumer health - Schwannoma.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19951057.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Grant] United States / Howard Hughes Medical Institute / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 87
  •  go-up   go-down


87. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102 Suppl:195-9
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm3.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Female. Follow-Up Studies. Hearing Disorders / diagnosis. Hearing Disorders / etiology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging. Radiation Dosage. Severity of Illness Index. Trigeminal Neuralgia / etiology. Tumor Burden / radiation effects

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15662809.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


88. Bian LG, Tirakotai W, Sun QF, Zhao WG, Shen JK, Luo QZ: Molecular genetics alterations and tumor behavior of sporadic vestibular schwannoma from the People's Republic of China. J Neurooncol; 2005 Jul;73(3):253-60
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular genetics alterations and tumor behavior of sporadic vestibular schwannoma from the People's Republic of China.
  • OBJECTIVES: To analyze the molecular genetic alteration of sporadic vestibular schwannomas from the People's Republic of China and to correlate these alterations with the tumor behaviors.
  • The proliferative index (LI) of vestibular schwannoma was evaluated by proliferative cell nuclear antigen investigation.
  • RESULTS: Sixteen vestibular schwannomas (44.4%) showed allele loss.
  • We found 22 mutations in 36 schwannomas.
  • The LI and the growth rate of schwannomas with LOH or mutation were significantly higher than those without LOH or mutation.
  • All of these vestibular schwannomas showed no immunoreaction to anti-NF2(A-19) IgG by immunohistochemistry.
  • By immunoblotting technique, reduced expression of S/M was found in 31 cases (86%).
  • The growth index of schwannomas with severely reduced expression of S/M was significantly higher than those with moderately reduced or normal expression.
  • CONCLUSION: The molecular genetic changes in sporadic vestibular schwannomas from Chinese patients were similar to the previous reports.
  • We demonstrate the relationship between tumor behaviors and genetic alteration (including LOH and mutation of NF2 gene).
  • We propose that inactivation of S/M, may be an important step in tumorigenesis of sporadic vestibular schwannoma.
  • [MeSH-major] Chromosomes, Human, Pair 22 / genetics. Genes, Neurofibromatosis 2. Neuroma, Acoustic / genetics. Neuroma, Acoustic / metabolism

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15980976.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Neurofibromin 2
  •  go-up   go-down


89. Solares CA, Panizza B: Vestibular schwannoma: an understanding of growth should influence management decisions. Otol Neurotol; 2008 Sep;29(6):829-34
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma: an understanding of growth should influence management decisions.
  • BACKGROUND: Treatments for vestibular schwannomas include surgical removal and radiotherapy.
  • Observation is a reasonable alternative, given the slow growth of these tumors.
  • METHODS: Patients with unilateral vestibular schwannomas who presented in the last 10 years were reviewed.
  • The following information was recorded from the charts: age, sex, tumor size at presentation and subsequent follow-up sessions, treatment in the event of growth, and time interval between presentation and last imaging available.
  • Interestingly, 11 patients (10%) demonstrated tumor regression.
  • Patients with intracanalicular tumors had a 5-year no-growth rate of 89.8% compared with 73.9% and 45.2% for Grade I and Grade II or larger tumors, respectively.
  • The difference between intracanalicular and Grade II or larger tumors was statistically significant (p = 0.0196).
  • CONCLUSION: Our data suggest that treatment can be delayed in a large proportion of vestibular schwannoma patients and that this is particularly true in patients with small tumors.
  • [MeSH-major] Ear Neoplasms / radiotherapy. Ear Neoplasms / surgery. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18636034.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


90. Kim KM, Park CK, Chung HT, Paek SH, Jung HW, Kim DG: Long-term Outcomes of Gamma Knife Stereotactic Radiosurgery of Vestibular Schwannomas. J Korean Neurosurg Soc; 2007 Oct;42(4):286-92

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term Outcomes of Gamma Knife Stereotactic Radiosurgery of Vestibular Schwannomas.
  • OBJECTIVE: Gamma Knife Stereotactic Radiosurgery (GK SRS) has become an important treatment modality for vestibular schwannomas.
  • We evaluated the tumor control rate, patterns of tumor volume change and preservation of hearing following low-dose radiation for vestibular schwannomas in a homogeneous cohort group in which the mean marginal dose was 12 Gy.
  • Regular MRI, audiometry and clinical evaluations were done and tumor volumes were obtained from MRI using the OSIRIS program.
  • RESULTS: The tumor control rate was 97%.
  • We were able to classify the patterns of change in tumor volume into three categories.
  • Transient increases in tumor volume were detected in 29% of the patients and the maximum transient increase in tumor volume was identified at 6 to 30 months after GK SRS.
  • The transient increases in tumor volume ranged from 121% to 188%.
  • CONCLUSION: Low-dose GK SRS was an effective and safe mode of treatment for vestibular schwannomas in comparison to the previously used high-dose GK SRS.
  • Transient increases in tumor volume can be identified during the follow-up period after low-dose GK SRS for vestibular schwannomas.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Neurochirurgie. 2004 Jun;50(2-3 Pt 2):312-9 [15179284.001]
  • [Cites] Neurosurgery. 1983 Jul;13(1):12-22 [6348580.001]
  • [Cites] Neurosurgery. 2003 Aug;53(2):282-87; discussion 287-8 [12925242.001]
  • [Cites] Otol Neurotol. 2003 May;24(3):465-8 [12806300.001]
  • [Cites] J Neurosurg. 2003 Apr;98(4):800-6 [12691405.001]
  • [Cites] Acta Neurochir Suppl. 2002;84:77-83 [12379008.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1265-78 [11483338.001]
  • [Cites] Acta Neurochir (Wien). 2001;143(7):689-95 [11534689.001]
  • [Cites] Neurosurgery. 2001 Dec;49(6):1299-306; discussion 1306-7 [11846928.001]
  • [Cites] Br J Neurosurg. 2006 Aug;20(4):195-202 [16954068.001]
  • [Cites] J Neurosurg. 2006 Oct;105(4):576-80 [17044561.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1295-8 [11483341.001]
  • [Cites] Neurosurgery. 2006 Feb;58(2):241-8; discussion 241-8 [16462477.001]
  • [Cites] J Neurosurg. 2005 Jul;103(1):53-8 [16121973.001]
  • [Cites] Cancer. 2005 Aug 1;104(3):580-90 [15952200.001]
  • [Cites] J Neurosurg. 2005 Jan;102(1):10-6 [15658090.001]
  • [Cites] J Neurosurg. 2005 Jan;102 Suppl:195-9 [15662809.001]
  • [Cites] J Neurosurg. 2001 Jan;94(1):1-6 [11147876.001]
  • [Cites] AJNR Am J Neuroradiol. 2000 Sep;21(8):1540-6 [11003293.001]
  • [Cites] J Neurosurg. 2000 Dec;93 Suppl 3:82-9 [11143269.001]
  • [Cites] J Neurosurg. 2000 May;92(5):745-59 [10794287.001]
  • [Cites] J Neurosurg. 2005 Jan;102 Suppl:114-8 [15662792.001]
  • [Cites] Neurosurg Focus. 2003 May 15;14(5):e3 [15669814.001]
  • [Cites] Stereotact Funct Neurosurg. 2004;82(4):147-52 [15467382.001]
  • [Cites] Stereotact Funct Neurosurg. 1998 Oct;70 Suppl 1:65-73 [9782237.001]
  • [Cites] N Engl J Med. 1998 Nov 12;339(20):1426-33 [9811917.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1997 Dec 1;39(5):983-8 [9392535.001]
  • [Cites] Neurol Med Chir (Tokyo). 1995 Oct;35(10):737-41 [8532129.001]
  • [Cites] Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1153-60 [7607937.001]
  • [Cites] Acta Neurochir Suppl. 1994;62:93-7 [7717145.001]
  • [Cites] Radiother Oncol. 1993 May;27(2):91-8 [8356233.001]
  • [Cites] Ann Otol Rhinol Laryngol. 1988 Jan-Feb;97(1):55-66 [3277525.001]
  • [Cites] Neurol Res. 2003 Oct;25(7):682-90 [14579782.001]
  • (PMID = 19096558.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2588215
  • [Keywords] NOTNLM ; Gamma knife / Long-term outcome / Low dose / Vestibular schwannomas
  •  go-up   go-down


91. Chin KF, Babar J, Tzifa K, Chavda SV, Irving RM: Vestibular schwannomas with fluid-fluid level. J Laryngol Otol; 2007 Sep;121(9):902-6
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannomas with fluid-fluid level.
  • Vestibular schwannomas containing cystic parts are common, but it is extremely rare for a vestibular schwannoma to contain fluid-fluid levels.
  • In this report, we present two cases of vestibular schwannoma with magnetic resonance imaging findings of a fluid-fluid level, and we discuss the radiological features and possible mechanism of fluid-fluid level formation.
  • [MeSH-major] Cyst Fluid. Neuroma, Acoustic / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17320004.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  •  go-up   go-down


92. Müller S, Arnolds J, van Oosterhout A: Decision-making of vestibular schwannoma patients. Acta Neurochir (Wien); 2010 Jun;152(6):973-84
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Decision-making of vestibular schwannoma patients.
  • BACKGROUND: Patients suffering from vestibular schwannoma can choose between four modalities of management:.
  • METHOD: This study is based on postal questionnaire survey of 739 vestibular schwannoma patients (survey response rate, 78%).
  • CONCLUSION: The praxis of patient counselling of acoustic neuroma patients in Germany is far from the ideal condition of medical consultation: The most important shortcoming is that it is unilateral: About 69% of the patients are informed about only one treatment option, generally surgery.
  • [MeSH-major] Decision Making. Dose Fractionation. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Patient Participation. Radiosurgery

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20169371.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
  •  go-up   go-down


93. Nouraei SA, Huys QJ, Chatrath P, Powles J, Harcourt JP: Screening patients with sensorineural hearing loss for vestibular schwannoma using a Bayesian classifier. Clin Otolaryngol; 2007 Aug;32(4):248-54
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Screening patients with sensorineural hearing loss for vestibular schwannoma using a Bayesian classifier.
  • OBJECTIVES: Selecting patients with asymmetrical sensorineural hearing loss for further investigation continues to pose clinical and medicolegal challenges, given the disparity between the number of symptomatic patients, and the low incidence of vestibular schwannoma as the underlying cause.
  • We developed and validated a diagnostic model using a generalisation of neural networks, for detecting vestibular schwannomas from clinical and audiological data, and compared its performance with six previously published clinical and audiological decision-support screening protocols.
  • PARTICIPANTS: Clinical and audiometric details of 129 patients with, and as many age and sex-matched patients without vestibular schwannomas, as determined with magnetic resonance imaging.
  • MAIN OUTCOME MEASURES: The ability to diagnose a patient as having or not having vestibular schwannoma.
  • RESULTS: A Gaussian Process Ordinal Regression Classifier was trained and cross-validated to classify cases as 'with' or 'without' vestibular schwannoma, and its diagnostic performance was assessed using receiver operator characteristic plots.
  • DISCUSSION: The Gaussian Process ORdinal Regression Classifier increased the flexibility and specificity of the screening process for vestibular schwannoma when applied to a sample of matched patients with and without this condition.
  • [MeSH-major] Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis

  • Genetic Alliance. consumer health - Schwannoma.
  • Genetic Alliance. consumer health - Sensorineural hearing loss.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17651265.001).
  • [ISSN] 1749-4478
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


94. Rutten I, Baumert BG, Seidel L, Kotolenko S, Collignon J, Kaschten B, Albert A, Martin D, Deneufbourg JM, Demanez JP, Stevenaert A: Long-term follow-up reveals low toxicity of radiosurgery for vestibular schwannoma. Radiother Oncol; 2007 Jan;82(1):83-9
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up reveals low toxicity of radiosurgery for vestibular schwannoma.
  • AIM: The long-term effects of radiosurgery of vestibular schwannomas were investigated in a group of consecutively treated patients.
  • METHODS AND MATERIALS: Between 1995 and 2001, 26 patients (median age: 67, range: 30-82) with a vestibular schwannoma were treated by Linac-based stereotactic radiosurgery (SRS).
  • Five-year-probability of preservation of hearing and facial nerve function was 96% and 100%, respectively.
  • CONCLUSIONS: With the doses used, our study demonstrates that SRS provides an equivalent tumour control rate when compared to surgery, as well as on a long-term basis, an excellent preservation of the facial and the acoustic nerves.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / adverse effects

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17182142.001).
  • [ISSN] 0167-8140
  • [Journal-full-title] Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • [ISO-abbreviation] Radiother Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  •  go-up   go-down


95. Ito E, Saito K, Yatsuya H, Nagatani T, Otsuka G: Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2. Neurosurg Rev; 2009 Oct;32(4):425-33
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Factors predicting growth of vestibular schwannoma in neurofibromatosis type 2.
  • We retrospectively reviewed characteristics of patients with neurofibromatosis type 2 to identify factors predicting further growth of bilateral vestibular schwannomas.
  • Subjects comprised 27 neurofibromatosis type 2 patients with 54 vestibular schwannomas, followed for 24-204 months (mean, 86 months).
  • This study investigated factors predictive of vestibular schwannoma growth in neurofibromatosis type 2.
  • Features distinguishing actively growing from quiescent VS were determined for untreated course (28 vestibular schwannomas) and posttreatment course (including either resection or radiosurgery; 33 vestibular schwannomas).
  • A general estimation equation was used to identify factors affecting tumor growth.
  • During the untreated course, 19 vestibular schwannomas showed growth and 9 vestibular schwannomas were stable.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Neurofibromatosis 2 / pathology. Neuroma, Acoustic / pathology. Trigeminal Nerve / pathology
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Analysis of Variance. Child. Child, Preschool. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Predictive Value of Tests. Radiosurgery. Retrospective Studies. Tomography, X-Ray Computed. Young Adult


96. Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P: True incidence of vestibular schwannoma? Neurosurgery; 2010 Nov;67(5):1335-40; discussion 1340
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] True incidence of vestibular schwannoma?
  • BACKGROUND: The incidence of diagnosed sporadic unilateral vestibular schwannomas (VS) has increased, due primarily to more widespread access to magnetic resonance imaging.
  • OBJECTIVE: To present updated epidemiological data on VS incidence, as well as patient age, hearing acuity, tumor size, and localization at diagnosis for the last 4 decades in an unselected population, with emphasis on developments in recent years.
  • Incidence during the period, patient sex and age, data on hearing (pure tone average and speech discrimination), and tumor size at diagnosis were retrieved from the database.
  • Mean tumor size at diagnosis decreased from 30 mm in 1979 to 10 mm in 2008, whereas hearing acuity at diagnosis has improved over the years.
  • CONCLUSION: After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
  • Whereas the sex ratio and age at diagnosis have remained grossly unchanged over the years, hearing has improved, and tumor size has decreased considerably.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20871439.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


97. Chan AW, Black P, Ojemann RG, Barker FG 2nd, Kooy HM, Lopes VV, McKenna MJ, Shrieve DC, Martuza RL, Loeffler JS: Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicity. Neurosurgery; 2005 Jul;57(1):60-70; discussion 60-70
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicity.
  • OBJECTIVE: To determine the outcome and toxicity in patients with vestibular schwannomas treated with conventionally fractionated stereotactic radiotherapy (SRT) and to identify prognostic factors that are predictive of outcome.
  • METHODS: Between 1992 and 2001, 70 patients with vestibular schwannomas were treated with linear accelerator-based SRT in our institutions.
  • The median tumor volume was 2.4 cm3 (range, 0.05-21.1 cm3).
  • The indications for SRT were distributed as follows: 47% newly diagnosed, 31% progressive tumors after watchful waiting, 3% adjuvant postoperative radiation, and 19% recurrent tumors after surgical resection.
  • RESULTS: Tumor recurrence was defined as progressive enlargement of tumor on follow-up magnetic resonance imaging studies.
  • One patient had a tumor recurrence at 38 months after SRT.
  • The actuarial tumor control rates were 100 and 98% at 3 and 5 years, respectively.
  • Three patients with a median tumor volume of 16.2 cm3 required surgical resection for persistent or increasing symptoms at a median of 37 months.
  • In multivariate analysis, tumor volume at time of treatment was predictive for neurosurgical intervention (surgical resection or shunt placement) after SRT (P = 0.001).
  • The 3- and 5-year actuarial rates of freedom from any neurosurgical intervention were 100 and 97% for patients with tumor volume less than 8 cm3 and 74 and 47% respectively for patients with tumor of at least 8 cm3 (P < 0.0001).
  • The 3-year actuarial rates of facial and trigeminal nerve preservation were 99 and 96%, respectively.
  • There was no difference in tumor control and cranial nerve function preservation rates seen in NF2 patients compared with non-NF2 patients.
  • Patients with large tumors are more likely to undergo neurosurgical interventions after SRT.
  • [MeSH-major] Dose Fractionation. Neuroma, Acoustic / surgery. Radiosurgery / methods. Stereotaxic Techniques. Treatment Outcome

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15987541.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


98. Stangerup SE, Caye-Thomasen P, Tos M, Thomsen JC: [Incidence of vestibular schwannoma in Denmark]. Ugeskr Laeger; 2008 Oct 13;170(42):3335-8
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Incidence of vestibular schwannoma in Denmark].
  • INTRODUCTION: During the last 30 years the number of diagnosed vestibular schwannomas (VS) has increased from 15 in 1976 to 116 in 2006.
  • CONCLUSION: With easier access to MRI, vestibular schwannomas are found earlier when they are still small.
  • [MeSH-major] Neuroma, Acoustic / epidemiology

  • Genetic Alliance. consumer health - Schwannoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18940171.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Denmark
  •  go-up   go-down


99. Wickremesekera A, Hovens CM, Kaye AH: Expression of ErbB-1 and 2 in vestibular schwannomas. J Clin Neurosci; 2007 Dec;14(12):1199-206
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of ErbB-1 and 2 in vestibular schwannomas.
  • Using immunohistochemistry and Western blot techniques we have shown an increased expression of ErbB-2 and no expression of ErbB-1 in vestibular schwannomas (VS).
  • [MeSH-major] Cranial Nerve Neoplasms / metabolism. Neuroma, Acoustic / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis
  • [MeSH-minor] Animals. Blotting, Western. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Cells, Cultured. Glioblastoma / metabolism. Glioblastoma / pathology. Humans. Immunohistochemistry. Immunoprecipitation. Mice. Neoplasm Proteins / chemistry. Neoplasm Proteins / isolation & purification

  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17964790.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
  •  go-up   go-down


100. Mautner VF, Nguyen R, Kutta H, Fuensterer C, Bokemeyer C, Hagel C, Friedrich RE, Panse J: Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2. Neuro Oncol; 2010 Jan;12(1):14-8
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bevacizumab induces regression of vestibular schwannomas in patients with neurofibromatosis type 2.
  • Bilateral vestibular schwannomas are the hallmark of neurofibromatosis type 2 (NF2), and these tumors impair hearing and frequently lead to deafness.
  • Neurosurgical intervention, the only established treatment, often damages the vestibular nerve.
  • We report 2 cases in which treatment with bevacizumab (for 3 months in one case and 6 months in the other) induced regression of progressive vestibular schwannomas by more than 40% and substantially improved hearing in the patient treated for 6 months.
  • Bevacizumab therapy may thus provide an effective treatment for progressive vestibular schwannomas in patients with NF2.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Agents / therapeutic use. Neurofibromatosis 2 / drug therapy. Neuroma, Acoustic / drug therapy

  • Genetic Alliance. consumer health - Neurofibromatosis.
  • Genetic Alliance. consumer health - Neurofibromatosis type 2.
  • MedlinePlus Health Information. consumer health - Acoustic Neuroma.
  • MedlinePlus Health Information. consumer health - Cancer Chemotherapy.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Neurosurg. 2002 Jun;96(6):1063-71 [12066908.001]
  • [Cites] Neurosurgery. 1996 May;38(5):880-5; discussion 885-6 [8727812.001]
  • [Cites] J Med Genet. 2006 Apr;43(4):289-94 [16155191.001]
  • [Cites] Neurosurgery. 2007 Mar;60(3):460-8; discussion 468-70 [17327790.001]
  • [Cites] J Neurooncol. 2009 Feb;91(3):329-36 [18953493.001]
  • [Cites] J Clin Oncol. 2007 Oct 20;25(30):4705-6 [17947716.001]
  • [Cites] Neurology. 2008 Mar 4;70(10):779-87 [18316689.001]
  • [Cites] Nat Clin Pract Oncol. 2008 Aug;5(8):487-91 [18560388.001]
  • [Cites] J Neurooncol. 2007 Jul;83(3):259-66 [17570036.001]
  • (PMID = 20150363.001).
  • [ISSN] 1523-5866
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Antineoplastic Agents; 2S9ZZM9Q9V / Bevacizumab
  • [Other-IDs] NLM/ PMC2940556
  •  go-up   go-down






Advertisement