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Items 1 to 100 of about 1205
1. Nascentes SM, Paulo EA, de Andrade EC, da Silva AL, Vassoler TM, Scanavini AB: Sudden deafness as a presenting symptom of acoustic neuroma: case report. Braz J Otorhinolaryngol; 2007 Sep-Oct;73(5):713-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sudden deafness as a presenting symptom of acoustic neuroma: case report.
  • Vestibular schwannoma, also known as acoustic neurinoma, is the most frequent tumor of the cerebellopontine angle, and represents 9% of all intracranial tumors.
  • The patients responded to therapy with Prednisone and Pentoxifylline after the diagnosis of acoustic neurinoma by imaging exams.
  • [MeSH-major] Deafness / etiology. Neuroma, Acoustic / complications. Tinnitus / etiology


2. Diyora B, Sharma A, Badhe P, Nayak N: Hemorrhage in acoustic neurinoma. Neurol India; 2010 Mar-Apr;58(2):329-30
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  • [Title] Hemorrhage in acoustic neurinoma.
  • [MeSH-major] Hemorrhage / complications. Neuroma, Acoustic / complications

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  • (PMID = 20508368.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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3. Nunes TP, Sardinha M, Pereira IC, Lunardelli P, Matayoshi S: [Gold weight implantation: premature and late complications]. Arq Bras Oftalmol; 2007 Jul-Aug;70(4):599-602
Hazardous Substances Data Bank. GOLD, ELEMENTAL .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Implante de peso de ouro: complicações precoces e tardias.
  • METHODS: Charts of 20 patients with lagophthalmos secondary to facial nerve palsy of diverse etiologies, which were submitted to gold weight implantation in the upper eyelid of the affected side, were retrospectively examined.
  • RESULTS: The most frequent cause of paralytic lagophthalmos was acoustic neurinoma after surgery (40%).
  • The complications were divided into early, possibly related to the material impurity and the late, due to the evolution of the facial nerve palsy that presented a decrease in muscle tonus.

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  • (PMID = 17906754.001).
  • [ISSN] 0004-2749
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] por
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 7440-57-5 / Gold
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4. Shantaram M, Rao A, Aroor AR, Raja A, Rao S, Monteiro F: Assessment of total sialic acid and lipid-bound sialic acid in management of brain tumors. Ann Indian Acad Neurol; 2009 Jul;12(3):162-6
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  • [Title] Assessment of total sialic acid and lipid-bound sialic acid in management of brain tumors.
  • BACKGROUND: Glycoconjugate molecules expressed at the plasma membrane of mammalian cells have been reported to be associated with tumor progression.
  • The measurement of total sialic acid (TSA) and lipid-bound sialic acid (LBSA) in the cerebrospinal fluid (CSF) is suggested to be useful for the diagnosis of brain tumors.
  • But there are very few reports available on the serum glycoconjugate levels in patients with brain tumors.
  • OBJECTIVE: The objective of this study is to check the feasibility of using serum glycoconjugates such as TSA and LBSA as tumor markers in brain tumor patients.
  • MATERIALS AND METHODS: Colorimetric estimation of TSA using diphenylamine was done on 100 patients with intracranial tumors; follow-up study was carried out in 24 cases.
  • The LBSA fraction was isolated from the serum of 68 brain tumor patients and evaluated using phosphotungstic acid and resorcinol; follow-up study was done on 23 patients.
  • The various types of brain tumors included in this study were glioma, meningioma, and acoustic neurinoma as well as some other types such as medulloblastoma, secondary tumors, and craniopharyngioma.
  • DISCUSSION: TSA and LBSA do not have the ability to discriminate between benign and malignant brain tumors.
  • TSA and LBSA appear to be tumor markers of very limited value in patients with brain tumors.

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  • (PMID = 20174496.001).
  • [ISSN] 1998-3549
  • [Journal-full-title] Annals of Indian Academy of Neurology
  • [ISO-abbreviation] Ann Indian Acad Neurol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2824932
  • [Keywords] NOTNLM ; Brain tumors / lipid-bound sialic acid / total sialic acid / tumor markers
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5. Marcucci R, Alessandrello Liotta A, Cellai AP, Rogolino A, Berloco P, Leprini E, Pagnini P, Abbate R, Prisco D: Cardiovascular and thrombophilic risk factors for idiopathic sudden sensorineural hearing loss. J Thromb Haemost; 2005 May;3(5):929-34
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  • No clear causes for this disease have been found thus far, but cochlear ischemia has been hypothesized in patients in whom an infectious episode or acoustic neurinoma have been excluded.
  • OBJECTIVES: The aim of this case-control study was to investigate a number of acquired and inherited thrombophilic risk factors [antithrombin, protein C and S; factor V (FV) Leiden, FII polymorphism; lupus anticoagulant (LA); anticardiolipin (aCL) antibodies; fasting homocysteine (Hcy); lipoprotein(a) (Lp(a)); plasminogen activator inhibitor-1 (PAI-1)] in addition to cardiovascular risk factors in patients with idiopathic SSHL (ISSHL).
  • These preliminary data suggest that hypercholesterolemia, hyperhomocysteinemia, elevated PAI-1 levels and anticardiolipin antibodies are associated with ISSHL, so indirectly supporting the hypothesis of a vascular occlusion in the pathogenesis of the disease.

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  • (PMID = 15869586.001).
  • [ISSN] 1538-7933
  • [Journal-full-title] Journal of thrombosis and haemostasis : JTH
  • [ISO-abbreviation] J. Thromb. Haemost.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Anticardiolipin; 0 / Antithrombins; 0 / Lipoprotein(a); 0 / Lupus Coagulation Inhibitor; 0 / Plasminogen Activator Inhibitor 1; 0 / Protein C; 0 / Protein S; 0 / factor V Leiden; 0LVT1QZ0BA / Homocysteine; 9001-24-5 / Factor V
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6. Coca Pelaz A, Fernández Lisa C, Gómez JR, Rodrigo JP, Llorente JL, Suárez C: [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications]. Acta Otorrinolaringol Esp; 2008 May;59(5):223-7
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  • [Title] [Complete facial palsy following surgery for acoustic nerve neurinoma: evolution and associated ophthalmological complications].
  • [Transliterated title] Parálisis facial completa tras cirugía de neurinoma del acústico: evolución y complicaciones oftalmológicas asociadas.
  • OBJECTIVE: To evaluate the fraction of patients recovering to normal function after complete facial nerve paralysis secondary to acoustic neuroma surgery, and also to address the ophthalmologic complications associated with it and the therapeutic options.
  • MATERIAL AND METHOD: We performed a retrospective review of 30 cases operated on in our department for acoustic neuroma and who, despite anatomical preservation of the facial nerve, developed a complete post-operative facial nerve paralysis (grade VI of House-Brackmann [HB]).
  • RESULTS: Only 5 of the 30 cases studied (16.6 %) recovered to normal facial nerve function (HB grade I).
  • [MeSH-major] Cochlear Nerve / pathology. Cochlear Nerve / surgery. Corneal Ulcer / etiology. Facial Paralysis / etiology. Facial Paralysis / physiopathology. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Peripheral Nervous System Neoplasms / pathology. Peripheral Nervous System Neoplasms / surgery. Postoperative Complications
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 18501157.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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7. Helbig S, Rader T, Bahmer A, Baumann U: A case of bilateral cochlear implantation in single-sided untreated acoustic neurinoma. Acta Otolaryngol; 2009 Jun;129(6):694-6
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  • [Title] A case of bilateral cochlear implantation in single-sided untreated acoustic neurinoma.
  • Acoustic neurinoma affects the acousticofacial nerve and therefore in many cases is a contraindication for cochlear implantation and an indication for brainstem implant.
  • The first case of bilateral cochlear implantation in a patient with single-sided untreated acoustic neurinoma is described here.
  • In a 49-year-old woman with progressive hearing loss during the last 12 years we preoperatively diagnosed an acoustic neurinoma of the left side.
  • [MeSH-major] Cochlear Implants. Hearing Loss, Bilateral / rehabilitation. Neuroma, Acoustic / complications

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  • (PMID = 19012062.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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8. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma. Neurosurgery; 2006 Jul 01;59(1):E206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary Melanocytic Tumor of the Cerebellopontine Angle Mimicking a Vestibular Schwannoma.

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  • (PMID = 28180621.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Stojicic MT, Slavik EE, Acimovic GT, Jovanovic MD, Stojmirovic DM, Vujotic LD: Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report. J Plast Reconstr Aesthet Surg; 2008 Nov;61(11):e9-11
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  • [Title] Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report.
  • This article presents a successful surgical treatment of the patient with aggressive basal cell carcinoma with intracranial propagation (ulcer terebrans) and simultaneous acoustic neurinoma on the same side.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Neoplasms, Multiple Primary / surgery. Neuroma, Acoustic / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Brain / pathology. Female. Humans. Magnetic Resonance Imaging. Meninges / pathology. Middle Aged. Neoplasm Invasiveness. Reconstructive Surgical Procedures / methods. Scalp / pathology

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  • (PMID = 18718834.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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10. Machinis TG, Fountas KN, Dimopoulos V, Robinson JS: History of acoustic neurinoma surgery. Neurosurg Focus; 2005 Apr 15;18(4):e9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] History of acoustic neurinoma surgery.
  • The purpose of this article is to provide insight into the development of surgery for acoustic neurinomas throughout the years.
  • The advances in surgical techniques from the very first operations for acoustic tumors at the end of the 19th century until today are described, with special emphasis on the technological and diagnostic milestones that preceded each step of this development.
  • [MeSH-major] Neuroma, Acoustic / history. Neuroma, Acoustic / surgery. Neurosurgery / history. Neurosurgical Procedures / history. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Cranial Fossa, Posterior / pathology. Cranial Fossa, Posterior / surgery. Facial Nerve Injuries / prevention & control. History, 19th Century. History, 20th Century. Humans. Intraoperative Complications / prevention & control. Microsurgery / history. Microsurgery / methods. Postoperative Complications / prevention & control. Radiosurgery / history. Radiosurgery / methods. Temporal Bone / pathology. Temporal Bone / surgery

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  • (PMID = 15844872.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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11. Bouchene M, Pavillon S, Zaouche S, Boulud B, Dubreuil C: [Predictive factors of facial palsy of the acoustic neurinoma after retrosigmoid surgery: 230 cases]. Ann Otolaryngol Chir Cervicofac; 2006 Dec;123(6):319-24
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  • [Title] [Predictive factors of facial palsy of the acoustic neurinoma after retrosigmoid surgery: 230 cases].
  • [Transliterated title] Facteurs prédictifs de la survenue des paralysies faciales du neurinome de l'acoustique opéré par voie rétro-sigmoïde. A propos de 230 cas.
  • OBJECTIVES: To determine predictive factors influencing postoperative facial palsy during retro sigmoid approach in vestibular schwannoma surgery.
  • MATERIAL AND METHODS: Retrospective study over 230 patients with vestibular schwannoma, mostly stade I and II, operated by retro sigmoid approach, by the same oto neuro chirurgical team between 1993 and 2004.
  • Pre and post operative parameters taken into consideration: quantitative: age and sex, audiometric parameters, duration of clinical symptoms; qualitative: tumor anatomic factors and facial nerve function according to House Brackmann classification.
  • RESULTS: 8 days after surgery, 92% of patients have a normal or subnormal facial nerve function, 5% a facial paresis and 3% a paralysis.
  • Latency of vertigo with facial nerve paralysis is 4.33 vs. 1.97 year in absence of paralysis.
  • Hearing conservation is 85% without facial nerve paralysis vs. 58% with facial nerve paralysis; Wave III latency (PEAP) with facial nerve paralysis is 4.54 vs. 4.28 ms if not.
  • CONCLUSION: Significant predictive factors of facial nerve palsy outcome are: age, post surgery hearing conservation, wave III latency, difficulty in tumor dissection, vertigo latency.
  • [MeSH-major] Facial Paralysis / etiology. Neuroma, Acoustic / surgery. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Child. Evoked Potentials. Facial Nerve / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Retrospective Studies. Sex Factors. Time Factors. Vertigo / etiology

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  • (PMID = 17202990.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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12. Schipper J, Sarikaya-Seiwert S, Hänggi D, Turowski B, Klenzner T: [Juvenile craniocervical acoustic neurinoma]. Laryngorhinootologie; 2010 Mar;89(3):162-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Juvenile craniocervical acoustic neurinoma].
  • [MeSH-major] Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Angiography, Digital Subtraction. Humans. Hydrocephalus / diagnosis. Hydrocephalus / etiology. Hydrocephalus / surgery. Hypoglossal Nerve / surgery. Magnetic Resonance Imaging. Male. Microsurgery / methods. Postoperative Complications / etiology. Reoperation. Tomography, X-Ray Computed. Tracheotomy

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  • (PMID = 19718619.001).
  • [ISSN] 1438-8685
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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13. Tran Ba Huy P, Kania R, Legac MS: [Vestibular schwannoma (acoustic neurinoma). Natural history and quality of life]. Bull Acad Natl Med; 2008 Dec;192(9):1725-37; discussion 1738-40
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  • [Title] [Vestibular schwannoma (acoustic neurinoma). Natural history and quality of life].
  • [Transliterated title] Schwannome vestibulaire (neurinome de l'acoustique). Histoire naturelle et qualité de vie.
  • Management of patients with vestibular shwannomas has gradually improved with the development of stereotaxic radiotherapy, our better understanding of these tumours' natural history, and the increasing accent placed on quality of life.
  • The aim of this study was two-fold:--to evaluate the natural history and tumor growth in a series of 386 patients presenting with small- or medium-sized tumors amenable to conservative management; and ii) to compare quality of life in 356 patients undergoing surgery (n = 198), radiosurgery (n = 23) or conservative management (n = 135).
  • The annual tumor growth rate was < 1 mm in 58.6% of patients, 1-3 mm in 29.2%, and > 3 mm in 12.2%.
  • The overall growth rate did not differ significantly between intrameatal and extrameatal tumors (1.02 +/- 1.8 and 1.40 +/- 3.1 mm/y, respectively).
  • The tumor growth rate was not related to sex, age, initial hearing status or initial tumor grade.
  • Late diagnosis was the only factor significantly associated with the tumor growth rate.
  • [MeSH-major] Neuroma, Acoustic / therapy. Quality of Life

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  • (PMID = 19718978.001).
  • [ISSN] 0001-4079
  • [Journal-full-title] Bulletin de l'Académie nationale de médecine
  • [ISO-abbreviation] Bull. Acad. Natl. Med.
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Netherlands
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14. Bösel J, Klingebiel R, Schielke E: HIV-associated neurosyphilis mimicking acoustic neurinoma. J Neurol; 2006 Feb;253(2):250-2
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  • [Title] HIV-associated neurosyphilis mimicking acoustic neurinoma.
  • [MeSH-major] HIV Infections / complications. Neuroma, Acoustic / physiopathology. Neurosyphilis / diagnosis. Neurosyphilis / etiology

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  • (PMID = 16047112.001).
  • [ISSN] 0340-5354
  • [Journal-full-title] Journal of neurology
  • [ISO-abbreviation] J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Germany
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15. Sugimoto S, Sugimoto A, Saita K, Kishi M, Shioya K, Higa T: [An improved case of bedridden mental impairment with normal pressure hydrocephalus associated with acoustic neurinoma after tumor resection]. Rinsho Shinkeigaku; 2008 Aug;48(8):575-8
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  • [Title] [An improved case of bedridden mental impairment with normal pressure hydrocephalus associated with acoustic neurinoma after tumor resection].
  • Cranial CT and MRI revealed marked ventricular enlargement and a cerebellopontine angle tumor.
  • After removal of the tumor, ventricle size and CSF protein decreased, and the symptoms of cognitive impairment and motor dysfunction resolved.
  • Histological examination showed acoustic neurinoma.
  • Over the half of hydrocephalus following acoustic neurinoma shows a tendency to improve by surgical resection of the tumor.
  • [MeSH-major] Cognition Disorders / etiology. Hydrocephalus, Normal Pressure / etiology. Neuroma, Acoustic / complications

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  • (PMID = 18939477.001).
  • [ISSN] 0009-918X
  • [Journal-full-title] Rinshō shinkeigaku = Clinical neurology
  • [ISO-abbreviation] Rinsho Shinkeigaku
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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16. Sánchez-Legaza E, Meléndez Guerrero B, Sánchez Legaza B, Idelfonso Miranda J: [Acoustic neurinoma shown as a facial palsy]. An Otorrinolaringol Ibero Am; 2007;34(6):565-72
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  • [Title] [Acoustic neurinoma shown as a facial palsy].
  • [Transliterated title] Neurinoma del acústico manifestado como una parálisis facial.
  • Acoustic neurinoma is the most frequent benign tumour at the cerebellopontile angle.
  • We present the case of a vestibular schwannoma in a pregnant lady diagnosed by a peripheral facial palsy.
  • [MeSH-major] Ear Neoplasms / diagnosis. Facial Paralysis / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 18293776.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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17. Tlachacova D, Schmitt M, Novotny J Jr, Novotny J, Majali M, Liscak R: A comparison of the gamma knife model C and the Automatic Positioning System with Leksell model B. J Neurosurg; 2005 Jan;102(s_supplement):25-28

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Data were analyzed in patients in whom the following diagnoses had been made: vestibular schwannoma, pituitary adenoma, meningioma, solitary metastasis, and other benign and malignant solitary tumors.
  • CONCLUSIONS: With the C model there was a better conformity for most treated targets, such as vestibular schwannomas (p = 0.005) and meningiomas (p = 0.015).

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  • (PMID = 28306471.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; conformity index / extracranial exposure / staff exposure / stereotactic radiosurgery
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18. Chung WY, Liu KD, Shiau CY, Wu HM, Wang LW, Guo WY, Ming-Tak Ho D, Hung-Chi Pan D: Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases. J Neurosurg; 2005 Jan;102(s_supplement):87-97

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases.
  • OBJECT: The authors conducted a study to determine the optimal radiation dose for vestibular schwannoma (VS) and to examine the histopathology in cases of treatment failure for better understanding of the effects of irradiation.
  • Seventy-two patients (37%) had undergone partial or total excision of their tumor prior to gamma knife surgery (GKS).
  • The mean tumor volume was 4.1 cm<sup>3</sup> (range 0.04-23.1 cm<sup>3</sup>).
  • Multiisocenter dose planning placed a prescription dose of 11 to 18.2 Gy on the 50 to 94% isodose located at the tumor margin.
  • At the latest MR imaging assessment decreased or stable tumor volume was demonstrated in 93.6% of the patients.
  • Uncontrolled tumor swelling was noted in five patients at 3.5, 17, 24, 33, and 62 months after GKS, respectively.
  • Histopathological examination of specimens in three cases (one at 62 months after GKS) revealed a long-lasting radiation effect on vessels inside the tumor.
  • A margin 12-Gy dose with homogeneous distribution is effective in preventing tumor progression, while posing no serious threat to normal cranial nerve function.

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  • (PMID = 28306447.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / stereotaxy / vestibular schwannoma
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19. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102(s_supplement):195-199

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm<sup>3</sup>.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.

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  • (PMID = 28306432.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / radiosurgery / vestibular schwannoma
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20. van Eck AT, Horstmann GA: Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma. J Neurosurg; 2005 Jan;102(s_supplement):204-206

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma.
  • OBJECT: Gamma knife surgery (GKS) for vestibular schwannoma is still associated with an additional hearing loss of approximately 30%.
  • The mean tumor volume was 2.28 cm<sup>3</sup>.
  • After a mean follow-up duration of 22 months, the magnetic resonance imaging-based tumor control rate was 87%.
  • One patient suffered transient facial nerve impairment.
  • CONCLUSIONS: Reducing the maximum dose to 20 Gy seems to be an effective treatment, which probably increases preservation of functional hearing without sacrificing the high tumor control rates achieved in radiosurgery.
  • Post-radiosurgery tumor swelling occurred in 25% of the cases and was not correlated with hearing deterioration.

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  • (PMID = 28306452.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; acoustic neurinoma / gamma knife surgery / hearing preservation / tumor swelling / vestibular schwannoma
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21. Wowra B, Muacevic A, Jess-Hempen A, Hempel JM, Müller-Schunk S, Tonn JC: Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience. J Neurosurg; 2005 Jan;102(s_supplement):114-118

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outpatient gamma knife surgery for vestibular schwannoma: definition of the therapeutic profile based on a 10-year experience.
  • OBJECT: The purpose of the study was to define the therapeutic profile of outpatient gamma knife surgery (GKS) for vestibular schwannoma (VS) by using sequential tumor volumetry to quantify changes following treatment.
  • The actuarial 6-year tumor control rate after a single GKS treatment was 95%.
  • Tumor swelling was observed in 43 patients (38.7%).
  • Recurrence was significantly associated with NF2 (p < 0.003) and the reduced dose (p < 0.03) delivered to these tumors.
  • The incidence of facial nerve neuropathy was mainly determined by surgery prior to GKS (p < 0.0001).
  • Facial nerve radiation toxicity was mild and transient.
  • No permanent facial nerve toxicity was observed.
  • The risk of hearing loss was correlated with age and transient tumor swelling (p < 0.05) but not with dose parameters or NF2.

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  • (PMID = 28306422.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / tumor volumetry / vestibular schwannoma
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22. Yamakami I, Yoshinori H, Saeki N, Wada M, Oka N: Hearing preservation and intraoperative auditory brainstem response and cochlear nerve compound action potential monitoring in the removal of small acoustic neurinoma via the retrosigmoid approach. J Neurol Neurosurg Psychiatry; 2009 Feb;80(2):218-27
MedlinePlus Health Information. consumer health - Acoustic Neuroma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation and intraoperative auditory brainstem response and cochlear nerve compound action potential monitoring in the removal of small acoustic neurinoma via the retrosigmoid approach.
  • OBJECTIVE: Hearing preservation is the main focus of small acoustic neurinoma (AN) removal.
  • We have introduced a newly designed intracranial electrode enabling continuous monitoring of the cochlear nerve compound action potential (CNAP).
  • [MeSH-major] Action Potentials / physiology. Cochlear Nerve / pathology. Cochlear Nerve / surgery. Ear Neoplasms. Evoked Potentials, Auditory, Brain Stem / physiology. Hearing Loss, Sensorineural / diagnosis. Hearing Loss, Sensorineural / epidemiology. Monitoring, Intraoperative. Neuroma, Acoustic. Otologic Surgical Procedures / methods

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  • (PMID = 18977821.001).
  • [ISSN] 1468-330X
  • [Journal-full-title] Journal of neurology, neurosurgery, and psychiatry
  • [ISO-abbreviation] J. Neurol. Neurosurg. Psychiatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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23. Kakigi A, Nakatani H, Takeda T: Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma. ORL J Otorhinolaryngol Relat Spec; 2010;71 Suppl 1:78-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma.
  • OBJECTIVE: Auditory disorders of the contralateral ear in patients with unilateral acoustic neurinoma have previously been reported using the auditory brainstem response.
  • From our survey of the literature, there is no reported result about electrocochleography (ECoG) in the contralateral ear of acoustic neurinoma cases.
  • In the present study, we reported ECoG and pure-tone audiometric results of the contralateral ears in cases of unilateral acoustic neurinoma and the relationship between ECoG findings and tumor size was discussed.
  • METHODS: ECoG and pure-tone audiometry were performed for the contralateral ears in 27 cases of unilateral acoustic neurinoma, and the relationships between tumor size and contralateral ECoG findings and between pure-tone threshold and ECoG findings were investigated.
  • The tumor size was assessed by magnetic resonance imaging.
  • Incidences of abnormal -SP/AP ratio were 30.0% in large tumors (n = 10), 33.3% in mid-size tumors (n = 6) and 18.2% in small tumors (n = 11).
  • There was no correlation between the incidences of abnormal -SP/AP ratio and tumor size.
  • CONCLUSION: These results suggest that any size of acoustic neurinoma may affect contralateral electrocochleographic findings.
  • [MeSH-major] Audiometry, Evoked Response / methods. Audiometry, Pure-Tone. Neuroma, Acoustic / physiopathology

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  • (PMID = 20185954.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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24. Myrseth E, Møller P, Wentzel-Larsen T, Goplen F, Lund-Johansen M: Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life. Neurosurgery; 2006 Jul 01;59(1):67-76

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Untreated Vestibular Schwannoma: Vertigo is a Powerful Predictor for Health-Related Quality of Life.

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  • (PMID = 28180608.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Hasegawa T, Kida Y, Yoshimoto M, Koike J, Goto K: TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas. Neurosurgery; 2006 Jun 01;58(6):1119-1128

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] TABLEEvaluation of Tumor Expansion after Stereotactic Radiosurgery in Patients Harboring Vestibular Schwannomas.

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  • (PMID = 28173267.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Gavra M, Thanos L, Pomoni M, Batakis N: Spontaneous subarachnoid haemorrhage due to acoustic neurinoma. Case report and review of the literature. Br J Neurosurg; 2010 Feb;24(1):82-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spontaneous subarachnoid haemorrhage due to acoustic neurinoma. Case report and review of the literature.
  • Subarachnoid haemorrhage (SAH) of the posterior fossa in cases of acoustic neurinoma is very rare.
  • The authors present the clinical, neuroradiological and histological findings of an acoustic neurinoma presenting with SAH.
  • The literature regarding this subject is reviewed and the pathogenesis of haemorrhage from neurinoma is discussed.
  • [MeSH-major] Neuroma, Acoustic / complications. Subarachnoid Hemorrhage / etiology

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  • (PMID = 20158360.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 3
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27. Yonekawa Y: [Operative neurosurgery: personal view and historical backgrounds (2) acoustic neurinoma]. No Shinkei Geka; 2006 Dec;34(12):1265-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Operative neurosurgery: personal view and historical backgrounds (2) acoustic neurinoma].
  • Microsurgical removal of acoustic neurinoma is still one of the challenging topics in neurosurgery in spite of the development of Gamma-knife or radiosurgery, with which small and moderate sized tumors can be treated.
  • Surgical technique necessitates more expertise in dealing with larger tumors.
  • In this report ongoing microsurgical standard technique for removal of acoustic neurinomas of approx.
  • 3) Intracapsular enucleation after the dural incision and retraction of the biventer lobule with special emphasis on the infrequent anatomical course of the facial and vestibulocochlear nerves on the posterior wall of neurinomas.
  • 4) Localizing the facial nerve and vestibulocochlear nerve at the pontine side, so that decision of preserving or sacrificing the latter in the course of surgery can be made from the viewpoint of hearing preservation and concentrate on facial nerve function.
  • 6) Reduction of remaining tumor-capsule volume by sharp dissection or bipolar cutting, using intraoperative EMG-stimulation which identifies the presence of flattened facial nerve fibers on the capsule.
  • Presence tiny remnant of the tumor capsule attached to the nerve bundles just before the entrance of internal acoustic porus (macroscopical "radical" resection) is considered to be acceptable for better postoperative quality of life.
  • 9) Results of 88 cases during last 10 years are: good function (HB I and II) of the facial nerve 90.5% at the time of two years follow-up, 11.5% hearing preservation, 1 mortality due to aspiration pneumonia.
  • [MeSH-major] Microsurgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Radiosurgery

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  • (PMID = 17154074.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Historical Article; Journal Article
  • [Publication-country] Japan
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28. Kurowska-Mroczek E, Zabek M, Osuch B, Stelmachów J: Therapeutic management of acoustic neurinoma during twin pregnancy: a case report. J Reprod Med; 2009 Jun;54(6):393-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Therapeutic management of acoustic neurinoma during twin pregnancy: a case report.
  • BACKGROUND: Acoustic neuromas belong to relatively rare illnesses in pregnant women.
  • Magnetic resonance imaging showed a vestibular acoustic neuroma of cranial nerve VII on the right side.
  • On the 14th postoperative day a team of neurosurgeons performed a right suboccipital craniectomy and completely removed the tumor.
  • CONCLUSION: The treatment of acoustic neuroma depends on the general health of a patient and the length of pregnancy.
  • If symptoms of intracranial compression quickly worsen, an immediate intervention is often required regardless of the pregnancy stage.
  • [MeSH-major] Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Pregnancy Complications, Neoplastic / diagnosis. Pregnancy Complications, Neoplastic / surgery. Pregnancy, Multiple

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  • (PMID = 19639930.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Rubio-Palau J, Mareque-Bueno J, Garcia-Linares J, Malet-Hernandez D, Raspall-Martin G, Munill-Ferrer M, Martinez-Fuster X: Transmandibular-cervical approach for treatment of a CSF fistula through the Eustachian tube. J Craniomaxillofac Surg; 2009 Dec;37(8):474-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • It is a transmandibular-cervical approach to eliminate a cerebrospinal fluid fistula in the Eustachian tube produced after the removal of an acoustic neurinoma in a patient operated multiple times without success.
  • [MeSH-minor] Aged. Cautery. Female. Humans. Lingual Nerve / surgery. Neuroma, Acoustic / surgery. Osteotomy / methods. Palate, Hard / surgery. Palate, Soft / surgery. Postoperative Complications / surgery. Recurrence. Reoperation

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  • (PMID = 19664931.001).
  • [ISSN] 1878-4119
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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30. Sugita-Kitajima A, Koizuka I: Evaluation of the vestibulo-ocular reflex using sinusoidal off-vertical axis rotation in patients with acoustic neurinoma. Neurosci Lett; 2009 Oct 2;462(1):6-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of the vestibulo-ocular reflex using sinusoidal off-vertical axis rotation in patients with acoustic neurinoma.
  • The vestibulo-ocular reflex (VOR) was studied to examine the utility of off-vertical axis rotation (OVAR) in the diagnosis of acoustic neurinoma.
  • Thirteen patients with acoustic neurinomas were investigated.
  • Results showed that VOR gain during OVAR at 0.8 Hz and in a 30 degrees nose-up position in patients with internal auditory canal tumors was significantly less than the gain measured during EVAR.
  • The VOR gain measured from all patients (including those with tumors extending to the cerebellopontine angle) was not significantly different when the patients were subjected to EVAR and OVAR.
  • These observations were possibly due to superior vestibular nerve dysfunction.
  • We concluded that certain stimulating parameters--patient's nose tilted up 30 degrees; sinusoidal OVAR at 0.8 Hz and 60 degrees /s maximum angular head velocity--were useful for evaluating vestibular function in patients suffering from an acoustic neurinoma located within the internal auditory canal.
  • [MeSH-major] Ear Neoplasms / diagnosis. Neuroma, Acoustic / diagnosis. Reflex, Vestibulo-Ocular. Rotation

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  • (PMID = 19560514.001).
  • [ISSN] 1872-7972
  • [Journal-full-title] Neuroscience letters
  • [ISO-abbreviation] Neurosci. Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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31. Firat AK, Karakaş HM, Kahraman B, Firat Y, Altinok T, Kizilay A: [Dynamic contrast-enhanced magnetic resonance imaging findings of mass lesions of the pontocerebellar angle]. Kulak Burun Bogaz Ihtis Derg; 2007;17(4):217-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In this study, we investigated the role of dynamic contrast-enhanced MRI in the differential diagnosis of acoustic neurinoma, meningioma, and paraganglioma.
  • PATIENTS AND METHODS: Twelve patients (8 females, 4 males; mean age 47.5 years; range 8 to 71 years) whose diagnoses were acoustic neurinoma (n=3), paraganglioma (n=5), and meningioma (n=4) were evaluated by simultaneous conventional and dynamic contrast-enhanced MRI.
  • RESULTS: According to the four main time-signal intensity curve patterns described in the literature, acoustic neurinomas, meningiomas, and paragangliomas exhibited type C, type A-B, and type A curve patterns, respectively.
  • CONCLUSION: Our results suggest that dynamic contrast MRI may have an additional but limited role in the differential diagnosis of extra-axial intracranial tumors such as those of the pontocerebellar angle.
  • [MeSH-major] Brain Neoplasms / pathology. Cerebellopontine Angle / pathology. Magnetic Resonance Imaging
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Contrast Media. Female. Humans. Male. Meningioma / pathology. Middle Aged. Neuroma, Acoustic / pathology. Paraganglioma / pathology. Predictive Value of Tests

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  • (PMID = 18187974.001).
  • [ISSN] 1300-7475
  • [Journal-full-title] Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat
  • [ISO-abbreviation] Kulak Burun Bogaz Ihtis Derg
  • [Language] tur
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Contrast Media
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32. Kabacińska A, Dabrowska A, Tarnowska C, Cyryłowski L: [Diagnostic problems of rare cerebellopontine angle tumors]. Otolaryngol Pol; 2007;61(2):184-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Diagnostic problems of rare cerebellopontine angle tumors].
  • Astrocytoma (neuroepithelial tumor) determine about 25% all the cerebroma but their original location in cerebellopontine angle is seldom.
  • In case of this kind of tumors in this place, the symptoms can be non-characteristic and similar to these, which appear in the acoustic neurinoma.
  • The most important in case of this diagnosis is both that this tumors can infiltrate of the brain tissues and the fact that they can transformate toward the anaplastic astrocytoma or glioblastoma multiforme (very malignant tumors).
  • MATERIAL AND METHODS: [corrected] A rare case of astrocytoma presenting as a cerebellopontine angle tumor is discussed.
  • The special characteristics of this tumor and unusual clinical course are disscused.
  • [MeSH-major] Astrocytoma / radiography. Astrocytoma / surgery. Cerebellar Neoplasms / radiography. Cerebellar Neoplasms / surgery. Cerebellopontine Angle / radiography. Cerebellopontine Angle / surgery. Facial Nerve Diseases / pathology

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  • (PMID = 17668807.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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33. Helling K: [Function disorders of otoliths: clinical aspects and therapy options]. HNO; 2008 Oct;56(10):996-1002
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In the clinical routine, the diagnostic of the lateral gait is often comparable with a complete peripheral vestibular function examination.
  • Participation of the saccule has been described for vestibular neuropathy, Menière's disease, bilateral vestibulopathy and acoustic neurinoma.
  • Only by an exact diagnostic of diseases of the otolithic organs can individual disease courses be differential diagnostically separated from each other.
  • [MeSH-major] Gait Disorders, Neurologic / diagnosis. Gait Disorders, Neurologic / therapy. Otolithic Membrane. Vestibular Diseases / diagnosis. Vestibular Diseases / therapy

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  • (PMID = 18810373.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 20
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34. Cardis E, Richardson L, Deltour I, Armstrong B, Feychting M, Johansen C, Kilkenny M, McKinney P, Modan B, Sadetzki S, Schüz J, Swerdlow A, Vrijheid M, Auvinen A, Berg G, Blettner M, Bowman J, Brown J, Chetrit A, Christensen HC, Cook A, Hepworth S, Giles G, Hours M, Iavarone I, Jarus-Hakak A, Klaeboe L, Krewski D, Lagorio S, Lönn S, Mann S, McBride M, Muir K, Nadon L, Parent ME, Pearce N, Salminen T, Schoemaker M, Schlehofer B, Siemiatycki J, Taki M, Takebayashi T, Tynes T, van Tongeren M, Vecchia P, Wiart J, Woodward A, Yamaguchi N: The INTERPHONE study: design, epidemiological methods, and description of the study population. Eur J Epidemiol; 2007;22(9):647-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The study focused on tumours arising in the tissues most exposed to RF fields from mobile phones: glioma, meningioma, acoustic neurinoma and parotid gland tumours.
  • INTERPHONE is the largest case-control study to date investigating risks related to mobile phone use and to other potential risk factors for the tumours of interest and includes 2,765 glioma, 2,425 meningioma, 1,121 acoustic neurinoma, 109 malignant parotid gland tumour cases and 7,658 controls.
  • [MeSH-major] Cell Phones / utilization. Epidemiologic Methods. Neoplasms / epidemiology. Radio Waves / adverse effects

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  • (PMID = 17636416.001).
  • [ISSN] 0393-2990
  • [Journal-full-title] European journal of epidemiology
  • [ISO-abbreviation] Eur. J. Epidemiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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35. Takeda T, Kakigi A, Takebayashi S, Ohono S, Nishioka R, Nakatani H: Narrow-band evoked oto-acoustic emission from ears with normal and pathologic conditions. ORL J Otorhinolaryngol Relat Spec; 2010;71 Suppl 1:41-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Narrow-band evoked oto-acoustic emission from ears with normal and pathologic conditions.
  • CONCLUSION: Evoked oto-acoustic emission (EOAE), in particular the slow component, is fragile with the inner ear lesions and is apt to disappear in impaired ears.
  • EOAE testing was performed in 40 normal ears and 111 ears with pathologic disorders, including sudden deafness, Ménière's disease and surgically proven acoustic neurinomas.
  • Spontaneous oto-acoustic emission was investigated in some cases.
  • In acoustic neurinoma, especially computed tomography scan and magnetic resonance imaging tests were performed to assess the tumor size. RESULTS:.
  • The prognosis of sudden deafness was good in cases where both a fast component and slow component were detected in the acute stage within 2 weeks after the deafness onset, and was pessimistic, when either or both of them failed to recover. (3) In Ménière's disease, EOAE was found in 6 (40%) of 15 cases with hearing loss >50 dB, and detected in 54 (90%) of 60 cases with slight to moderate deafness <50 dB HL.
  • Ultimately, the fast component also faded out if the hearing was severely impaired. (4) EOAEs were detectable in 20 (95.2%) of 21 ears with surgically proven acoustic neurinoma, 16 of which had both the slow and fast components.
  • The echo pattern of acoustic neurinoma was basically similar to that of normal ears, but the detection threshold was elevated to a varying degree, although there were some cases with much better detection threshold as compared with severe deafness.
  • [MeSH-major] Deafness / physiopathology. Meniere Disease / physiopathology. Neuroma, Acoustic / physiopathology. Otoacoustic Emissions, Spontaneous / physiology

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  • (PMID = 20185949.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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36. Valentino V, Benassi M, Strigari L: Historia magistra vitae (Cic. De or. 2.36). The Prime Objective of Radiosurgery in Acoustic Neurinomas. Neuroradiol J; 2006 Nov 30;19(5):637-44

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Historia magistra vitae (Cic. De or. 2.36). The Prime Objective of Radiosurgery in Acoustic Neurinomas.
  • The central question of stereotaxic radiosurgery in acoustic neurinomas is how to pinpoint its main objective: is it a better alternative to neurosurgery or an option when surgery is unfeasible?
  • The conclusions that can be drawn to date from our own findings and from others in the literature are the following: radiosurgery can be used not only to prevent neurinoma growth and at the same time to preserve the patient's neurological conditions without the risk of complications, but it can also be counted on to provide a cure.
  • The expression coined by Lars Leksell regarded precisely the innovation he himself conceived in the 'closed skull operation', with reference to its use in cases of acoustic neurinoma as an alternative to traditional surgery.

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  • (PMID = 24351267.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Liang C, Zhang B, Wu L, Du Y, Wang X, Liu C, Yu F: The superiority of 3D-CISS sequence in displaying the cisternal segment of facial, vestibulocochlear nerves and their abnormal changes. Eur J Radiol; 2010 Jun;74(3):437-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: To select the best imaging method for clinical otologic patients through evaluating 3D constructive interference of steady state (CISS) image quality in visualizing the facial, vestibulocochlear nerves (CN:VII-VIII) and their abnormal changes.
  • METHODS: The CN:VII-VIII as well as inner ear structures in 48 volunteers were examined using 3D-CISS and 3D turbo spin echo (TSE) sequences respectively, and displayed to the full at the reformatted and maximum intensity projection (MIP) images.
  • The nerve identification and image quality were graded for the CN:VII-VIII as well as inner ear structures.
  • Abnormal changes of the facial or vestibulocochlear nerves were clearly shown in 8 patients, among them 1 was caused by bilateral acoustic neurinoma, 1 by cholesteatoma at cerebellopontine angle, 1 by arachnoid cyst, 1 by neurovascular adhesion, 4 by neurovascular compression.
  • CONCLUSION: With 3D-CISS sequence the fine structure of the CN:VII-VIII and corresponding membranous labyrinth can be clearly demonstrated; lesions at the site of cerebellopontine angle can also be found easily.
  • [MeSH-major] Facial Nerve / pathology. Facial Nerve Diseases / pathology. Magnetic Resonance Imaging / methods. Vestibulocochlear Nerve / pathology. Vestibulocochlear Nerve Diseases / pathology

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  • [Copyright] Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • (PMID = 19394779.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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38. Radić B, Vukelić Z, Bognar SK: Serum gangliosides in patients with brain tumors. Coll Antropol; 2008 Jan;32 Suppl 1:171-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Serum gangliosides in patients with brain tumors.
  • In order to determine possible differences in serum gangliosides content and composition before and after surgical removal of tumor, gangliosides isolated from preoperative and postoperative sera of patients with brain tumors were analyzed.
  • Serum samples were collected from patients with glioblastoma, meningioma, acoustic neurinoma, haemangioma, oligodendroglioma and astrocytoma, one week before and one week after surgical removal of the tumor.
  • However, a postoperative decreased proportion of ganglioside GD3 was observed in sera derived from patients with complete tumor removal.
  • The results of this study indicate that comparative quantitative and compositional analysis of both preoperative and postoperative serum gangliosides may provide useful information concerning tumor progression, surgical success and prognosis.
  • [MeSH-major] Brain Neoplasms / blood. Gangliosides / blood

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  • (PMID = 18405078.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Croatia
  • [Chemical-registry-number] 0 / Gangliosides
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39. Miyazaki H, Deveze A, Magnan J: Neuro-otologic surgery through minimally invasive retrosigmoid approach: endoscope assisted microvascular decompression, vestibular neurotomy, and tumor removal. Laryngoscope; 2005 Sep;115(9):1612-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Neuro-otologic surgery through minimally invasive retrosigmoid approach: endoscope assisted microvascular decompression, vestibular neurotomy, and tumor removal.
  • By using this approach, we performed microvascular decompression for hemifacial spasm and trigeminal neuralgia, vestibular neurotomy for refractory Ménière's disease with repeated attacks of dizziness, and tumor removal of acoustic neurinoma.
  • [MeSH-major] Decompression, Surgical / methods. Endoscopy / methods. Microsurgery / methods. Neuroma, Acoustic / surgery. Vestibular Nerve / surgery
  • [MeSH-minor] Craniotomy / methods. Hemifacial Spasm / surgery. Humans. Meniere Disease / surgery. Postoperative Complications. Retrospective Studies. Treatment Outcome. Trigeminal Neuralgia / surgery

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  • (PMID = 16148704.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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40. Sakakura K, Takahashi K, Takayasu Y, Chikamatsu K, Furuya N: Novel method for recording vestibular evoked myogenic potential: minimally invasive recording on neck extensor muscles. Laryngoscope; 2005 Oct;115(10):1768-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Novel method for recording vestibular evoked myogenic potential: minimally invasive recording on neck extensor muscles.
  • OBJECTIVES: Vestibular evoked myogenic potential (VEMP) has been used to test vestibulocollic reflex.
  • In the cases of acoustic neurinoma, onset latencies were prolonged or nonexistent.
  • [MeSH-major] Evoked Potentials, Motor / physiology. Hearing Loss / diagnosis. Reflex / physiology. Vertigo / diagnosis. Vestibular Function Tests / methods

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  • (PMID = 16222192.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Hüfner K, Hamilton DA, Kalla R, Stephan T, Glasauer S, Ma J, Brüning R, Markowitsch HJ, Labudda K, Schichor C, Strupp M, Brandt T: Spatial memory and hippocampal volume in humans with unilateral vestibular deafferentation. Hippocampus; 2007;17(6):471-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spatial memory and hippocampal volume in humans with unilateral vestibular deafferentation.
  • Patients with acquired chronic bilateral vestibular loss were recently found to have a significant impairment in spatial memory and navigation when tested with a virtual Morris water task.
  • These deficits were associated with selective and bilateral atrophy of the hippocampus, which suggests that spatial memory and navigation also rely on vestibular input.
  • In the present study 16 patients with unilateral vestibular deafferentation due to acoustic neurinoma were examined 5- to 13-yrs post-surgery.
  • No significant deficits in spatial memory and navigation could be demonstrated in the patients with left vestibular failure, whereas patients with right vestibular loss showed a tendency to perform worse on the respective tests.
  • The subtle deficiencies with right vestibular loss are compatible with the recently described dominance of the right labyrinth and the vestibular cortex in the right hemisphere.
  • [MeSH-major] Functional Laterality. Hippocampus / pathology. Memory / physiology. Space Perception / physiology. Vestibular Diseases / pathology. Vestibular Diseases / physiopathology

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17397043.001).
  • [ISSN] 1050-9631
  • [Journal-full-title] Hippocampus
  • [ISO-abbreviation] Hippocampus
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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42. Shimizu S, Tanaka R, Oka H, Fujii K: Risk of damage to the endolymphatic sac and duct during removal of the posterior meatal wall: an anatomic study. Neurosurgery; 2006 Oct;59(4 Suppl 2):ONS435-9; discussion ONS439-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: With removal of the posterior meatal wall for intrameatal acoustic neurinoma, preservation of the structures adjacent to the internal acoustic meatus is important.
  • Distances measured were between the posterior meatal lip and the upper limit of the endolymphatic ledge, at the upper extent of the endolymphatic sac, and between a reference line extending from the inferior margin of the internal acoustic meatus posteriorly (parallel to the petrous ridge), simulating the inferior margin of the drilling, and the upper limit of the endolymphatic ledge.
  • After posterior meatal wall drilling, the distance between the posterior meatal lip and the vestibular aqueduct surrounding the endolymphatic duct and the depth of the structure from the surface were assessed.
  • RESULTS: The shortest distances between the posterior meatal lip and the endolymphatic ledge and between the posterior meatal lip and the vestibular aqueduct were 6.80 mm and 4.68 mm, respectively.
  • CONCLUSION: During surgical maneuvers to remove the posterior meatal wall, the occasional close proximity of the endolymphatic sac and endolymphatic duct to the internal acoustic meatus should be kept in mind.

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  • (PMID = 17041514.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Obrebowski A, Wiskirska-Woźnica B, Czerniejewska H: [Binaural asymmetric sensorineural hearing loss in audiological practice]. Otolaryngol Pol; 2010 Nov-Dec;64(6):382-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • After audiological examination 14% of this patients were qualified for MRI investigation, in 2 (3%) of them acoustic neurinoma was found.

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  • (PMID = 21302506.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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44. Schaaf H, Hesse G: [Low frequency fluctuating hearing loss without labyrinthine vertigo--a genuine disease? A follow up study after 4 and 10 years]. HNO; 2007 Aug;55(8):630-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Low frequency fluctuating hearing loss without labyrinthine vertigo--a genuine disease? A follow up study after 4 and 10 years].
  • BACKGROUND: Besides the typical attacks of dizziness, recurrent low-frequency sensory hearing loss--together with mostly low-frequency tinnitus--is also a characteristic sign of Menière's disease.
  • It is therefore often assumed to be a prodromal sign of Menière's disease, even without dizziness.
  • After a further 6 years, we investigated 46 (57%) of these original 81 patients in the second suspense year, 2005, for new components of vertigo, with the questions of development of Menière's disease and further development of the patients' hearing ability and psychic situation in mind.
  • RESULTS: In all, 12 (26%) of the 81 former patients suffered from vertigo, but only 4 (9%) had developed the typical signs of full-blown Menière's disease with the typical labyrinthine vertigo.
  • Of the 12 patients who suffered from vertigo, 6 (13% of the 81 with vertigo) were diagnosed with psychogenic vertigo, 1 (1%) suffered from benign and treatable paroxysmal positional vertigo and 1 (1%) had developed vertigo after acoustic neurinoma surgery.
  • CONCLUSIONS: We conclude from our observations that, although almost every patient with Menière's disease suffers from recurrent low-frequency hearing loss, only a few patients with recurrent hearing loss develop Menière's disease.
  • However, many patients with low-frequency sensory hearing loss develop anxiety leading to psychogenic dizziness in fearful expectation of "imminent" Menière's disease.
  • [MeSH-major] Hearing Loss, Sensorineural / classification. Hearing Loss, Sensorineural / diagnosis. Meniere Disease / classification. Meniere Disease / diagnosis. Terminology as Topic. Vertigo / classification. Vertigo / diagnosis

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  • (PMID = 17115089.001).
  • [ISSN] 1433-0458
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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45. Ferber-Viart C, Dubreuil C, Vidal PP: Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy. Audiol Neurootol; 2009;14(1):17-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy.
  • In animal models, acetyl-DL-leucine accelerates vestibular compensation following unilateral labyrinthectomy, and has only minor effects on normal vestibular function.
  • Our work in animal models suggested that acetyl-DL-leucine acted mainly on abnormally hyperpolarized and/or depolarized vestibular neurons by restoring their membrane potential towards a mean value of -65 to -60 mV.
  • Acute vestibular disorders are associated with asymmetrical spontaneous activities of vestibular neurons, so this previous study suggested that acetyl-DL-leucine may reduce acute, vestibular-related imbalances in humans.
  • To test this hypothesis, we investigated the efficacy of acetyl-DL-leucine during the acute stage following neurotomy or labyrinthectomy in patients undergoing surgery for unilateral vestibular acoustic neurinoma, or suffering from unilateral and intractable Ménière's disease.
  • By clinical testing of the vestibular function, patients were categorized according to the degree of compensation of the vestibular deafferentation prior to surgery.
  • For patients who displayed residual vestibular function before surgery, acetyl-DL-leucine eased the static vestibular syndromes, which followed neurotomy.
  • Our findings tend to confirm the view that acetyl-DL-leucine mainly acts, in humans, on abnormally hyperpolarized and/or depolarized vestibular neurons by restoring their membrane potential towards normal values; this is consistent with findings in guinea pigs following unilateral labyrinthectomy.
  • Moreover, it suggests that the degree of caloric paresis of the patients before neurotomy is useful both to predict the outcome of any acute vestibular syndrome following neurotomy and to assess the potential value of the administration of acetyl-DL-leucine to treat any such syndrome.
  • [MeSH-major] Leucine / analogs & derivatives. Meniere Disease / drug therapy. Meniere Disease / surgery. Neuroma, Acoustic / drug therapy. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Ear, Inner / surgery. Female. Humans. Male. Middle Aged. Postural Balance. Treatment Outcome. Vertigo / drug therapy. Vertigo / surgery. Vestibular Function Tests. Vestibular Nerve / surgery. Vomiting


46. Kunieda E, Deloar HM, Kitamura M, Kawaguchi O, Shiba H, Takeda A, Kawase T, Seki S, Shigematsu N, Kubo A: Rotational and translational reproducibility of newly developed Leksell frame-based relocatable fixation system. Radiat Med; 2006 Aug;24(7):503-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • MATERIALS AND METHODS: We analyzed 17 series of QA-CT data representing five patients who underwent stereotactic radiotherapy for treatment of acoustic neurinoma.
  • [MeSH-minor] Adult. Dose Fractionation. Equipment Design. Female. Humans. Male. Middle Aged. Movement. Neuroma, Acoustic / radiography. Neuroma, Acoustic / radiotherapy. Quality Control. Radiotherapy Dosage

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  • (PMID = 17058144.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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47. Lan Q, Qian ZY, Chen J, Liu SH, Lu ZH, Huang Q: [Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches]. Zhonghua Yi Xue Za Zhi; 2005 Jan 26;85(4):219-23
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches].
  • OBJECTIVE: To explore the surgical outcome and skills of keyhole approaches to posterior cranial fossa tumors.
  • METHODS: A retrospective analysis of the clinical data of 43 consecutive patients with posterior cranial fossa tumors, including acoustic neurinoma, petroclival meningioma, pons tumor, fourth ventricular tumor, etc. was conducted.
  • Subtemporal, retromastoid, or middle suboccipital keyhole approach was chosen respectively according to the anatomic positions of those different tumors.
  • RESULTS: The tumors were totally removed in 37 of the 43 patients (86.0%), subtotally removed in 5 (11.6%) and mostly removed in 1 (2.3%).
  • All of the 18 acoustic neurinomas (100%) were totally removed and the facial nerves of 15 patients (83.3%) were preserved anatomically, however, one patient died of brain stem edema on the 2nd postoperative day.
  • Among the 6 pons tumors 3 were removed totally and 3 subtotally.
  • All the other tumors were resected completely without neurological dysfunction observed, however, one patient with a cholesteatoma failed to demonstrate apparent improvement in his diplopia.
  • CONCLUSION: Microsurgical treatment of posterior cranial fossa tumors via keyhole approaches, with safe, succinct and minimally invasive property, is one of the promising directions in modern neurosurgery.
  • [MeSH-major] Brain Neoplasms / surgery. Meningeal Neoplasms / surgery. Meningioma / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery

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  • (PMID = 15854477.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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48. Otto M, von Mühlendahl KE: Electromagnetic fields (EMF): do they play a role in children's environmental health (CEH)? Int J Hyg Environ Health; 2007 Oct;210(5):635-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Final results of the INTERPHONE study on the risk of brain tumours, acoustic neurinoma and parotid gland tumours associated with the use of mobile phones will be soon available.
  • [MeSH-minor] Cell Phones. Child. Humans. Leukemia, Radiation-Induced / etiology. Microwaves

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  • (PMID = 17765660.001).
  • [ISSN] 1438-4639
  • [Journal-full-title] International journal of hygiene and environmental health
  • [ISO-abbreviation] Int J Hyg Environ Health
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 43
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49. Nguyen DQ, Boulat E, Troussier J, Reyt EI, Lavieille JP, Schmerber SI: [The jugulotympanic paragangliomas: 41 cases report]. Rev Laryngol Otol Rhinol (Bord); 2005;126(1):7-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Les paragangliomes tympano-jugulaires. A propos de 41 cas.
  • OBJECTIVE: The jugulotympanic paragangliomas (JTP) represents the most frequent tumour of the middle ear but also of the temporal bone, after the acoustic neurinoma.
  • Six stages A, 8 stages B and 27 stages C are reported in whom 20 cases (49%) presented an intracranial extension (classification of Fisch).
  • RESULTS: A total tumor removal without recurrence was achieved by surgery in more than 95% of the cases with 6 years follow-up but was associated with significant morbidity (major cranial nerve injury).
  • Because of the slow rate of growth, the radiotherapy is indicated for older patients, at risk for surgery or extensive tumors.
  • [MeSH-major] Ear Neoplasms / surgery. Glomus Jugulare Tumor / surgery. Glomus Tympanicum Tumor / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carotid Body Tumor / pathology. Carotid Body Tumor / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Radiotherapy, Adjuvant. Remission Induction. Retrospective Studies. Survival Rate

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  • (PMID = 16080641.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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50. Yu LM, Yang SM, Han DY, Yu LM, Yang WY: [Preliminary study of intraoperative auditory monitoring techniques in acoustic neuroma surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 May;41(5):335-40
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Preliminary study of intraoperative auditory monitoring techniques in acoustic neuroma surgery].
  • OBJECTIVE: To investigate the value of intraoperative auditory monitoring techniques in acoustic neuroma surgery.
  • METHODS: Ten cases with acoustic neuroma were resected with retrosigmoid approach.
  • The hearing was preserved in 2 cases, which had class A hearing post operation with tumor size <2 cm.
  • In another case, the waves of I, III could be evoked after the tumor resection with the disappearance of wave V.
  • The 6 out of 8 cases showed up CAP (waves I ) waveform.
  • The CAP amplitudes decreased significantly in 4 cases and even dropped to zero while dissecting the tumor at the lateral end of the internal auditory canal (IAC) or clamping the internal auditory artery (IAA) during operation.
  • In one case, although the cochlear nerve was cut down, the CAP could still be recorded after the tumor resection.
  • However, the CAP amplitudes was dropped to zero while pressurized and pulled cochlea nerve of brainstem lateral and the wave disappeared post-operation in another cases.
  • One of them showed low amplitude of CAP wave when the tumor partially removed.
  • CONCLUSIONS: In combination with ABR monitoring, ECochG proved to be a useful supplementary tool for hearing preservation in acoustic neurinoma surgery.
  • Drilling of the IAC and tumor removal at the lateral end of the IAC were the most critical steps for achieving hearing preservation.
  • The surgeon's experience are the most significant factors influencing the hearing outcome after removal of acoustic neuroma.
  • [MeSH-major] Cochlear Nerve / physiopathology. Monitoring, Intraoperative / methods. Neuroma, Acoustic / physiopathology
  • [MeSH-minor] Adolescent. Adult. Audiometry, Evoked Response. Evoked Potentials, Auditory, Brain Stem. Female. Humans. Male. Middle Aged. Young Adult

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  • (PMID = 16848284.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Evaluation Studies; Journal Article
  • [Publication-country] China
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51. Yonekawa Y: [On the occasion of my retirement as head of the Neurochirurgische Universitätsklinik Zürich--changing aspects of treatment modality in modern neurosurgery and of neuroscience research. Presentation of our experience and historical backgrounds]. Brain Nerve; 2008 May;60(5):538-46

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Traditionally, carotid endarterectomy belonged to vascular surgeons in our hospital, but the tendency of conversion from conventional carotid endarterectomy to endovascular PTA and/or stenting seemed to be marked, while microvascular revascularization procedure represented by extracranial intracranial EC-IC bypass remained constant (around 20/year) in various occasion (277 times on 203 cases: atherosclerosis 93, Moyamoya angiopathy (MMA) 47, aneurysm 57 and skull base tumour 6, during the last 13 years], in spite of negative results of EC-IC bypass international cooperative study for stroke prevention in 1985.
  • Acoustic neurinoma (just less than 20/year) is one of benign brain tumours whose treatment has changed remarkably.
  • Thanks to development of intaroperative neurophysiological monitoring and of surgical technique, preservation of facial nerve function has improved from 60% to more than 85% in spite of the increase of size.
  • [MeSH-minor] Brain Neoplasms / surgery. Cerebral Revascularization / methods. Cerebral Revascularization / trends. Humans. Hydrocephalus / surgery. Intracranial Aneurysm / surgery. Intracranial Arteriovenous Malformations / surgery. Switzerland. Universities

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  • (PMID = 18516976.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 33
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52. Yang SM, Yu LM, Yu LM, Han DY: [Technique of hearing preservation during acoustic neuroma surgery]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;43(8):564-9
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  • [Title] [Technique of hearing preservation during acoustic neuroma surgery].
  • OBJECTIVE: To explore the possibility of hearing protection in acoustic neurinoma (AN) resection and to evaluate the effect of dynamic auditory monitoring and the effect of oto-endoscope for hearing protection.
  • Maximal diameters of the tumor varied between 12 and 33 millimeters with an average of 19.9 millimeters.
  • All cases were operated on by retrosigmoid approach with routine facial nerve monitoring.
  • RESULTS: In all 18 cases, tumors were resected completely in 16 cases, but sub-totally removed in 2 cases which were II neurofibromatosis.
  • In all 18 cases, there were 5 cases with tumor diameter more than 20 millimeters, in which only 2 cases of them preserved hearing function (2/5).
  • However, 9 cases preserved their hearing function in the other 13 cases whose tumors diameter less than 20 millimeters (69.2%, 9/13).
  • During operative monitoring, when drilling posterior lip of internal auditory canal (IAC), dragging and electric coagulating nearby IAC, especially clamping labyrinthine artery, removing tumor in IAC or electric coagulating arachnoid blood vessel on the top of tumor tissue, the ABR waves were affected greatly.
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Otologic Surgical Procedures

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  • (PMID = 18959258.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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53. Chihara Y, Ito K, Sugasawa K, Shin M: Neurological complications after acoustic neurinoma radiosurgery: revised risk factors based on long-term follow-up. Acta Otolaryngol Suppl; 2007 Dec;(559):65-70
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  • [Title] Neurological complications after acoustic neurinoma radiosurgery: revised risk factors based on long-term follow-up.
  • CONCLUSIONS: The precise risk factors for neurological complications after acoustic neurinoma radiosurgery were identified on long-term follow-up.
  • Type 2 neurofibromatosis was found to be a risk factor for hearing loss and peripheral tumor dose was a risk factor for seventh and fifth cranial nerve injuries.
  • At the present time, controversy exists regarding history of prior surgical resection and tumor size as risk factors for cranial nerve complications.
  • PATIENTS AND METHODS: Between June 1990 and September 1998, 138 patients with acoustic neurinomas had SRS at Tokyo University Hospital.
  • The average tumor diameter ranged from 6.7 to 25.4 mm (mean 13.9 mm).
  • The maximum tumor doses ranged from 20 to 40 Gy (mean 29.8 Gy), and the peripheral doses ranged from 12 to 25 Gy (mean 15.4 Gy).
  • The neurological complications studied included hearing loss, facial palsy, and trigeminal nerve dysfunction.
  • The variables analyzed were age, gender, prior operation, neurofibromatosis type 2 (NF2), tumor diameter, maximum tumor dose, peripheral tumor irradiation dose, and the number of isocenters.
  • RESULTS: NF2 was significantly correlated with both total hearing loss and pure tone threshold (PTA) elevation; a history of prior surgical resection, tumor size, and the peripheral tumor dose were significantly correlated with facial palsy; and the peripheral tumor dose was significantly correlated with trigeminal neuropathy.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications
  • [MeSH-minor] Adolescent. Adult. Aged. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / etiology. Female. Follow-Up Studies. Hearing Disorders / epidemiology. Hearing Disorders / etiology. Humans. Male. Middle Aged. Neurofibromatosis 2 / epidemiology. Neurofibromatosis 2 / etiology. Prevalence. Radiosurgery / instrumentation. Risk Factors. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / etiology

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  • (PMID = 18340560.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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54. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102(s_supplement):111-113

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  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.

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  • (PMID = 28306427.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; facial function / gamma knife surgery / outcome / vestibular schwannoma
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55. Lavrova SA, Leshchinskiĭ VG, Shershever AS, Iazov OA, Gerasimov MV: [Predictive value of intraoperative monitoring of brainstem acoustic evoked potentials during removal of parabrainstem tumors]. Zh Vopr Neirokhir Im N N Burdenko; 2005 Apr-Jun;(2):8-12; discussion 12

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  • [Title] [Predictive value of intraoperative monitoring of brainstem acoustic evoked potentials during removal of parabrainstem tumors].
  • The data of intraoperative monitoring of brainstem acoustic evoked potentialities (BAEP) during parabrainstem tumors are analyzed.
  • Of the 24 cases, 16 patients were found to have neurinoma of the acoustic nerve, 4 had petroclival meningioma, 2, tentorial meningioma, 1, cholesteatoma of the cerebellopontine angle, and 1, brainstem angioma.
  • The authors proposed to identify the favorable and unfavorable patterns of BAEP as predictors of an early postoperative period, by comparing the patterns of BAEP, the data on the monitoring vital functions and outcomes of disease.
  • By taking into account the high coincidence of actual and predictable outcomes (79.16%), it can be suggested that the data of intraoperative monitoring of BAEP are not only of value for obtaining information at the moment of surgery, but also informative as a predictor of an early postoperative period and outcomes of disease.
  • [MeSH-major] Brain Stem Neoplasms / surgery. Evoked Potentials, Auditory, Brain Stem. Monitoring, Intraoperative / methods

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  • (PMID = 16078627.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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56. Coca Pelaz A, Rodrigo JP, Llorente JL, Gómez JR, Suárez C: [Unusual clinical presentations of vestibular schwannomas]. Acta Otorrinolaringol Esp; 2008 Apr;59(4):187-9
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  • [Title] [Unusual clinical presentations of vestibular schwannomas].
  • [Transliterated title] Formas clínicas inusuales de presentación de los neurinomas del acústico.
  • The aim of this study is evaluate the unusual ways of initial presentation of the vestibular schwannomas.
  • We performed a retrospective study of the patients who underwent resection of acoustic neuromas on our service, including for analysis only the cases which initial symptom was not the hearing loss.
  • Tumor size, localization, clinical presentation, and age of the patients were considered.
  • A significant group of patients did not present with the otological symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Cerebellopontine Angle / pathology. Hearing Loss / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 18447978.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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57. Chang LS, Welling DB: Molecular biology of vestibular schwannomas. Methods Mol Biol; 2009;493:163-77
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular biology of vestibular schwannomas.
  • Recent advances in molecular biology have led to a better understanding of the etiology of vestibular schwannomas.
  • The underlying purpose of vestibular schwannoma research is the development of new treatment options; however, such options have not yet been established.
  • A fundamental understanding of the underlying molecular events leading to tumor formation began when mutations in the neurofibromatosis type 2 (NF2) tumor suppressor gene were identified in vestibular schwannomas.
  • The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 (NF2) syndromes have both been related to alterations in the NF2 gene.
  • When utilized with clinical screening, such as magnetic resonance imaging (MRI), conventional audiometry, and auditory brainstem response (ABR), the early detection of NF2 can be made, which consequently makes a significant difference in the ability to successfully treat vestibular schwannomas.
  • Nf2-transgenic and knockout mice as well as vestibular schwannoma xenograft models are now ready for novel therapeutic testing.
  • [MeSH-major] Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Animals. DNA Mutational Analysis. Genetic Predisposition to Disease. Humans. Magnetic Resonance Imaging. Mice. Mice, Knockout. Mice, SCID. Mice, Transgenic. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / pathology

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  • (PMID = 18839347.001).
  • [ISSN] 1064-3745
  • [Journal-full-title] Methods in molecular biology (Clifton, N.J.)
  • [ISO-abbreviation] Methods Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
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58. Choy NL, Johnson N, Treleaven J, Jull G, Panizza B, Brown-Rothwell D: Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study. Aust J Physiother; 2006;52(3):211-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Balance, mobility and gaze stability deficits remain following surgical removal of vestibular schwannoma (acoustic neuroma): an observational study.
  • QUESTION: Are there residual deficits in balance, mobility, and gaze stability after surgical removal of vestibular schwannoma?
  • PARTICIPANTS: Twelve people with a mean age of 52 years who had undergone surgical removal of vestibular schwannoma at least three months previously and had not undergone vestibular rehabilitation.
  • CONCLUSION: A prospective study is required to evaluate vestibular rehabilitation to ameliorate dizziness and to improve balance, mobility, and gaze stability for this clinical group.
  • [MeSH-major] Mobility Limitation. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Ocular Motility Disorders / etiology. Postural Balance. Sensation Disorders / etiology


59. Dizdarević K, Link MJ: [Operative treatment of the vestibular schwannoma (acoustic neuroma): correlation between the microsurgical approach and cranial nerve lesion]. Med Arh; 2005;59(3):160-3
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  • [Title] [Operative treatment of the vestibular schwannoma (acoustic neuroma): correlation between the microsurgical approach and cranial nerve lesion].
  • [Transliterated title] Schwannoma vestibulare (neurinoma acustici)--operativni tretman: korelacija izmedu vrste mikroneurohirurskog pristupa i lezije kranijalnih nerava.
  • INTRODUCTION: Vestibular schwannoma (VS) is a benign tumour of cerebellopontine angle which total microsurgical resection is considered as a complex surgery.
  • Through analyzed series of operated patients (MJLink), we evaluated the correlation of VII and VIII nerves postoperative lesion with different operative approaches.
  • House-Brackmann grading scale is used for VII nerve deficit appraisal.
  • However, the most frequently used microsurgical approaches (retrosigmoid, translabyrinthine and extradural subtemporal) are still connected with certain morbidity rate, especially regarding the postoperative VII and VIII nerves lesion.
  • [MeSH-major] Microsurgery. Neuroma, Acoustic / surgery. Vestibulocochlear Nerve Injuries
  • [MeSH-minor] Facial Nerve Injuries / etiology. Humans. Intraoperative Complications


60. Mackle T, Rawluk D, Walsh RM: Atypical clinical presentations of vestibular schwannomas. Otol Neurotol; 2007 Jun;28(4):526-8
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  • [Title] Atypical clinical presentations of vestibular schwannomas.
  • A significant number of patients with vestibular schwannomas present atypically, with none of the classical symptoms of unilateral sensorineural hearing loss, tinnitus, and/or dysequilibrium.
  • STUDY DESIGN: The clinical data of all patients who presented to the vestibular schwannoma clinic at Beaumont Hospital over the past 12 years was prospectively recorded in a computerized database.
  • CONCLUSION: A significant subgroup, 3.7% in our study, did not present with the audiovestibular symptoms classically associated with vestibular schwannoma.
  • [MeSH-major] Neuroma, Acoustic / diagnosis

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  • (PMID = 17414179.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Arthurs BJ, Lamoreaux WT, Giddings NA, Fairbanks RK, Mackay AR, Demakas JJ, Cooke BS, Lee CM: Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature. World J Surg Oncol; 2009;7:100
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  • [Title] Gamma Knife radiosurgery for vestibular schwannoma: case report and review of the literature.
  • Vestibular schwannomas, also called acoustic neuromas, are benign tumors of the vestibulocochlear nerve.
  • Unfortunately, definitive guidelines for treating vestibular schwannomas are lacking, because of insufficient evidence comparing the outcomes of therapeutic modalities.We present a contemporary case report, describing the finding of a vestibular schwannoma in a patient who presented with dizziness and a "clicking" sensation in the ear, but no hearing deficit.
  • Audible clicking is a symptom that, to our knowledge, has not been associated with vestibular schwannoma in the literature.
  • This case highlights an atypical presentation of vestibular schwannoma, associated with audible "clicks" and normal hearing.
  • We also provide a concise review of the available literature on modern vestibular schwannoma treatment, which may be useful in guiding treatment decisions.
  • [MeSH-major] Neurilemmoma / surgery. Neuroma, Acoustic / surgery. Radiosurgery. Vestibular Nerve / surgery

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  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
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62. Propp JM, McCarthy BJ, Davis FG, Preston-Martin S: Descriptive epidemiology of vestibular schwannomas. Neuro Oncol; 2006 Jan;8(1):1-11
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  • [Title] Descriptive epidemiology of vestibular schwannomas.
  • Vestibular schwannomas, commonly termed acoustic neuromas, arise from the vestibular branch of the eighth cranial nerve (acoustic nerve) and are benign, slow-growing brain tumors that negatively impact patient quality of life.
  • They are thought to account for the majority of intracranial nerve sheath tumors.
  • To describe incidence rate patterns and trends of primary nerve sheath tumors of the brain/CNS and the subset of vestibular schwannomas in two population-based incidence registries, data were obtained from 11 Central Brain Tumor Registry of the United States (CBTRUS) collaborating state registries and the Los Angeles County Cancer Surveillance Program (LACCSP) (1975-1998).
  • Multiplicative Poisson regression models were used to compare trends in primary nerve sheath tumors of the brain/CNS overall and in subgroups, including vestibular schwannomas, controlling for age, gender, race, microscopic confirmation, and region.
  • The overall incidence of primary nerve sheath tumors of the brain/CNS was 1.1 per 100,000 person-years (CBTRUS, 1995-1999 and LACCSP, 1995-1998).
  • The incidence of vestibular schwannomas was similar for both data sets: 0.6 per 100,000 person-years (CBTRUS, 1995-1999) and 0.8 per 100,000 person-years (LACCSP, 1995-1998).
  • Moreover, the incidence of primary nerve sheath tumors of the brain/CNS overall (CBTRUS, 1985-1999 and LACCSP, 1975-1998) and of vestibular schwannomas (CBTRUS, 1992-1999 and LACCSP, 1992-1998) increased over time.
  • However, the incidence of benign schwannomas in sites other than the acoustic nerve either decreased (CBTRUS, 1992-1999) or experienced no significant change (LACCSP, 1992-1998).
  • [MeSH-major] Neuroma, Acoustic / epidemiology. Registries

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  • (PMID = 16443943.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1871924
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63. Régis J, Roche PH, Delsanti C, Thomassin JM, Ouaknine M, Gabert K, Pellet W: Modern management of vestibular schwannomas. Prog Neurol Surg; 2007;20:129-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Modern management of vestibular schwannomas.
  • Within the last 3 decades, microsurgery and stereotactic radiosurgery (SRS) have become well-established management options for vestibular schwannomas (VSs).
  • A long-term tumor control rate of 97%, transient facial palsy lower than 1%, and a probability of functional hearing preservation between 50 and 95% was achieved in this large series of patients treated with state-of-the-art SRS.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery

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  • (PMID = 17317981.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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64. Archibald DJ, Neff BA, Voss SG, Splinter PL, Driscoll CL, Link MJ, Dong H, Kwon ED: B7-H1 expression in vestibular schwannomas. Otol Neurotol; 2010 Aug;31(6):991-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] B7-H1 expression in vestibular schwannomas.
  • HYPOTHESIS: B7-H1 is expressed in vestibular schwannomas.
  • BACKGROUND: Little is known about how benign human vestibular schwannomas interact with antibody-mediated or cell-mediated immunity.
  • We report on the aberrant expression of a novel T-cell coregulatory molecule, B7 homolog 1 (B7-H1), in vestibular schwannomas and discuss the implications of B7-H1 expression and tumor aggressiveness and a potential regulator of B7-H1 expression.
  • METHODS: Immunohistochemical staining for B7-H1, CD8+, CD3+, and CD4+ lymphocytes were performed on 48 fresh-frozen vestibular schwannoma tissue specimens.
  • A clinical review of patient presenting symptoms and tumor characteristics was performed.
  • Real-time polymerase chain reaction was used to determine if there was differential expression of B7-H1 messenger RNA and microRNA-513, a known regulator of B7-H1, in several strongly positive and negative B7-H1 vestibular schwannomas.
  • RESULTS: Nine (19%) of 48 tumors were negative, 23 (48%) tumors were 1+ mildly positive (<20% section area), and 16 (33%) stained 2+ strongly positive (>or=20% section area) for B7-H1.
  • The average number of CD8 cells per high-power field was 2.1 for positive-staining tumors and 1.0 for negative tumors (p = 0.16).
  • Failure of tumor control with stereotactic radiation (p = 0.029) was significantly greater in the strongly positive B7-H1 tumors.
  • Real-time polymerase chain reaction did not show significant differential expression of microRNA-513 (p = 0.62) or B7-H1 messenger RNA (p = 0.35) between the tumors showing strong and negative immunohistochemical staining for B7-H1 protein.
  • CONCLUSION: Vestibular schwannoma tumors express B7-H1, which has been associated with immune tolerance and adverse disease characteristics in several malignancies.
  • Growing tumors that were surgically removed after failed stereotactic radiation therapy were significantly more likely to strongly express B7-H1 protein, which lends some credibility to the hypothesis that immuno-evasion may play some role in their continued growth.
  • Although clinical trends were seen, greater statistical power is required to evaluate whether B7-H1 expression correlates with more aggressive tumor growth or poorer hearing class.
  • B7-H1 seems to be expressed in equal amounts at the RNA level in all vestibular schwannoma tumors that suggests that differential protein expression is occurring at the posttranscriptional level.
  • However, microRNA-513 does not regulate B7-H1 protein expression in these tumors.

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  • (PMID = 20601920.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA134345-03; United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS242934; NLM/ PMC4810681
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65. Roche PH, Bouvier C, Chinot O, Figarella-Branger D: Genesis and biology of vestibular schwannomas. Prog Neurol Surg; 2008;21:24-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Genesis and biology of vestibular schwannomas.
  • This review chapter is a synthesis of the recent literature about pathogenesis of schwannomas with emphasis on vestibular schwannomas (VSs).
  • The cornerstone of cellular transformation and proliferation of Schwann cells toward schwannomas has been attributed to the nonexpression of normal schwannomin/merlin (S/M) by these cells.
  • The understanding of this mechanism has been gained from molecular genetic studies of neurofibromatosis type 2 (NF2) patients, in whom mutations of a tumor suppressor gene (NF2 gene) was clearly identified.
  • Lack of normal S/M protein in the schwannoma cell is due to gene mutation in 50% of sporadic VSs.
  • The exact interactions of S/M with extracellular matrix, membranous glycoprotein and cytoskeleton are not fully understood.
  • However, it is recognized that these interactions activate several pathways that might regulate cell-cycle process, apoptosis and intercellular interaction.
  • Apart from the involvement of the S/M pathway, the authors review the potential role of other genetic abnormalities and growing factors that are supposed to be involved in the pathogenesis of vs. Understanding the pathways of action and regulation of S/M may provide the basics for identifying potential therapeutic targets, which is of paramount importance for a better management of NF2 patients.
  • [MeSH-major] Genes, Neurofibromatosis 2 / physiology. Neurofibromin 2 / physiology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology

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  • (PMID = 18810196.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Neurofibromin 2
  • [Number-of-references] 43
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66. Shchekut'ev GA, Shimanskiĭ VN, Ogurtsova AA, Semenov MS: [Identification of the cochlear nerve in surgical removal of vestibular schwannomas]. Zh Vopr Neirokhir Im N N Burdenko; 2009 Jul-Sep;(3):10-3; discussion 13-4
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  • [Title] [Identification of the cochlear nerve in surgical removal of vestibular schwannomas].
  • Review of methods which allow intraoperative identifying and monitoring of cochlear and facial nerves in resection of vestibular schwannomas is presented.
  • We describe a case of successful identification and functional preservation of facial and cochlear nerves in a patient with acoustic neuroma.
  • According to some authors, application of intraoperative neurophysiological techniques in surgery of vestibular schwannomas allows to preserve not only anatomical but also functional integrity of neural structures as well.
  • [MeSH-major] Cochlear Nerve / physiology. Hearing Loss, Sensorineural / prevention & control. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods

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  • (PMID = 20088443.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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67. Jaiswal S, Agrawal V, Jaiswal AK, Pandey R, Mahapatra AK: Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance. J Negat Results Biomed; 2009;8:9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance.
  • OBJECTIVE: The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity.
  • MATERIALS AND METHODS: The study included 100 cases of vestibular schwannomas operated from January 2006 to June 2009.
  • Formaldehyde-fixed parafiin-embedded archival vestibular schwannomas specimens were used for the immunohistochemical assessment of estrogen and progesterone receptors.
  • CONCLUSION: No estrogen and progesterone receptor could be found in any of our 100 cases of vestibular schwannomas.
  • Hence our study does not support a causative role of estrogen and progesterone in the growth of vestibular schwannoma as well as hormonal manipulation in the treatment of this tumor.
  • [MeSH-major] Neurilemmoma / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism. Vestibular Diseases / metabolism

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  • [Cites] Acta Otolaryngol. 2000 Oct;120(8):950-4 [11200590.001]
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  • (PMID = 19889208.001).
  • [ISSN] 1477-5751
  • [Journal-full-title] Journal of negative results in biomedicine
  • [ISO-abbreviation] J Negat Results Biomed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
  • [Other-IDs] NLM/ PMC2777842
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68. Ambett R, Rupa V, Rajshekhar V: Analysis of causes for late presentation of Indian patients with vestibular schwannoma. J Laryngol Otol; 2009 May;123(5):502-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of causes for late presentation of Indian patients with vestibular schwannoma.
  • OBJECTIVE: To determine the causes of delay in diagnosis and treatment of Indian patients with vestibular schwannomas.
  • METHODS: In a prospective study from 2003 to 2005, 50 patients with a confirmed diagnosis of vestibular schwannoma were interviewed to determine the causes for (1) the delay between the patient noting the initial symptom and the definitive diagnosis, and (2) the reasons for delayed diagnosis.
  • After the patient had noted symptoms, the diagnosis of vestibular schwannoma was delayed due to doctor-related causes in 80 per cent of cases, and due to patient-related causes in 20 per cent.
  • CONCLUSIONS: Delay in the diagnosis of vestibular schwannoma in Indian patients is due to both doctor- and patient-related factors.
  • [MeSH-major] Hearing Loss, Sensorineural / etiology. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Health Knowledge, Attitudes, Practice. Humans. India. Male. Middle Aged. Prospective Studies. Referral and Consultation / standards. Time Factors. Tinnitus / etiology. Vertigo / etiology. Vestibular Function Tests. Young Adult

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  • (PMID = 18808730.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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69. Lobato-Polo J, Kondziolka D, Zorro O, Kano H, Flickinger JC, Lunsford LD: Gamma knife radiosurgery in younger patients with vestibular schwannomas. Neurosurgery; 2009 Aug;65(2):294-300; discussion 300-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery in younger patients with vestibular schwannomas.
  • OBJECTIVE: Management options for patients with vestibular schwannoma include observation, surgical resection, stereotactic radiosurgery (SRS), and stereotactic radiation therapy.
  • We studied tumor response and clinical outcomes after SRS in such patients.
  • METHODS: We reviewed long-term outcomes in 55 patients with vestibular schwannomas.
  • The median tumor volume was 1.7 mm.
  • The median tumor margin dose was 13.0 Gy (range, 11-20 Gy).
  • At the last assessment, facial and trigeminal nerve function was preserved in 98.2% and 96.4% of patients, respectively; the only facial deficit (House-Brackmann grade III) occurred in a patient who received a tumor dose of 20 Gy early in our experience (1988).
  • No patient developed a secondary radiation-related tumor.
  • CONCLUSION: Our experience indicates that GK SRS is an effective management strategy for younger patients with vestibular schwannoma, most of whom have no additional cranial nerve dysfunction.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / statistics & numerical data. Vestibular Nerve / surgery
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Cochlear Nerve / physiopathology. Cochlear Nerve / radiation effects. Facial Nerve / physiopathology. Facial Nerve / radiation effects. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Female. Hearing Loss, Sensorineural / epidemiology. Hearing Loss, Sensorineural / prevention & control. Humans. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Radiation Dosage. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / physiopathology. Trigeminal Nerve / radiation effects. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / prevention & control. Young Adult

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  • (PMID = 19625908.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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70. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):589-609, ix-x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / etiology. Headache / epidemiology. Headache / etiology. Humans. Meningitis / epidemiology. Meningitis / etiology. Neoplasm Recurrence, Local. Postoperative Complications. Postural Balance / physiology. Tinnitus / epidemiology. Tinnitus / etiology

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  • (PMID = 17544697.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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71. Battista RA: Gamma knife radiosurgery for vestibular schwannoma. Otolaryngol Clin North Am; 2009 Aug;42(4):635-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery for vestibular schwannoma.
  • Since Leksell first treated a patient who had a vestibular schwannoma in 1967, there has been a year-to-year increase in the number of patients treated with the gamma knife for vestibular schwannoma.
  • This article outlines the technique of GKRS and discusses the current results of its use to treat vestibular schwannomas.
  • Other topics discussed include tumor control, treatment of recurrent/residual and cystic vestibular schwannomas, and the results of treatment of neurofibromatosis type 2.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiation Injuries / prevention & control. Radiosurgery / methods
  • [MeSH-minor] Biopsy, Needle. Female. Follow-Up Studies. Humans. Immunohistochemistry. Male. Neoplasm Invasiveness / pathology. Neoplasm Staging. Patient Selection. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751869.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 62
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72. Sahu RN, Behari S, Agarwal VK, Giri PJ, Jain VK: Taste dysfunction in vestibular schwannomas. Neurol India; 2008 Jan-Mar;56(1):42-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Taste dysfunction in vestibular schwannomas.
  • BACKGROUND: Gustatory dysfunction associated with vestibular schwannomas (VS) is a poorly represented clinical presentation.
  • Preoperatively, taste disturbance was found in 29 (37.2%) giant, 28 (45.9%) large and one (33.3%) medium-sized tumors, respectively.
  • Among patients with anatomically preserved facial nerve, postoperative taste disturbances were found in 55 (42.3%) patients whereas nine (6.9%) patients reported improvement in taste sensations.
  • CONCLUSIONS: Taste dysfunction is common following vestibular schwannoma surgery.
  • Taste dysfunction should be included in the facial nerve functional grading system while assessing outcome.
  • [MeSH-major] Neuroma, Acoustic / complications. Taste Disorders / etiology

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  • (PMID = 18310836.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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73. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. 2007. Neurosurg Clin N Am; 2008 Apr;19(2):331-43, vii
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas. 2007.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534343.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Bennett M; Haynes DS
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74. Tan M, Myrie OA, Lin FR, Niparko JK, Minor LB, Tamargo RJ, Francis HW: Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007. Laryngoscope; 2010 Jan;120(1):144-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trends in the management of vestibular schwannomas at Johns Hopkins 1997-2007.
  • OBJECTIVES/HYPOTHESIS: To assess trends in the management of unilateral vestibular schwannomas over an 11-year period and to identify disease- and provider-related influences.
  • METHODS: Subjects presented to the Department of Otolaryngology-Head and Neck Surgery and the Department of Neurosurgery for management of unilateral vestibular schwannoma from 1997 through 2007, with at least two visits within the first year of presentation.
  • The proportion of patients for whom initial management consisted of observation, surgical resection, or radiation therapy was determined, and the relative influence of study year, patient age, hearing status, and tumor size was analyzed.
  • There were no changes in mean age or hearing status at diagnosis, but mean tumor size declined significantly.
  • Tumors that were surgically removed were on average 11.6 mm larger than those that were observed.
  • The increasing frequency over time of observation relative to surgery was significant even after controlling for age, hearing status, and tumor size.
  • CONCLUSIONS: Among patients managed by our center, there has been a significant shift in management of vestibular schwannomas over the last decade, with increasing tendency towards observation.
  • [MeSH-major] Ear Neoplasms / therapy. Neuroma, Acoustic / therapy

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  • (PMID = 19877188.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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75. Stangerup SE, Thomsen J, Tos M, Cayé-Thomasen P: Long-term hearing preservation in vestibular schwannoma. Otol Neurotol; 2010 Feb;31(2):271-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term hearing preservation in vestibular schwannoma.
  • OBJECTIVE: The aim of the present study was to evaluate the long-term hearing during "wait and scan" management of vestibular schwannomas.
  • SUBJECTS: During a 33-year period, from 1976 to 2008, 1,144 patients with vestibular schwannoma were allocated to observation by the wait and scan policy, with annual magnetic resonance imaging and audiologic examination.
  • CONCLUSION: Most vestibular schwannoma patients with 100% speech discrimination at diagnosis maintain good hearing even after many years of observation.
  • [MeSH-major] Hearing Loss / etiology. Hearing Loss / prevention & control. Neuroma, Acoustic / complications. Neuroma, Acoustic / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Audiometry, Pure-Tone. Databases, Factual. Denmark / epidemiology. Disease Progression. Female. Hearing / physiology. Humans. Male. Middle Aged. Speech Perception. Young Adult

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  • (PMID = 19887973.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Whitehouse K, Foroughi M, Shone G, Hatfield R: Vestibular schwannomas - when should conservative management be reconsidered? Br J Neurosurg; 2010 Apr;24(2):185-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannomas - when should conservative management be reconsidered?
  • OBJECTIVE: To document the natural history of vestibular schwannomas treated conservatively, and to find if there are any predictive factors for growth and need for active intervention.
  • SUBJECTS: Eighty-eight patients managed conservatively for unilateral vestibular schwannoma and that have had at least two radiological investigations.
  • RESULTS: Of the 88 patients, the average size of schwannoma at diagnosis was 10.88 mm.
  • 51.1% of schwannomas grew, 12.5% shrank and 36.4% remained the same size.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiography. Radiosurgery / methods
  • [MeSH-minor] Aged. Disease Progression. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Retrospective Studies. Risk Factors. Treatment Outcome. Tumor Burden

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  • (PMID = 19886818.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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77. Ferri GG, Modugno GC, Pirodda A, Fioravanti A, Calbucci F, Ceroni AR: Conservative management of vestibular schwannomas: an effective strategy. Laryngoscope; 2008 Jun;118(6):951-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of vestibular schwannomas: an effective strategy.
  • OBJECTIVES: Stimulated by the availability of a larger sample of patients and a longer follow-up period, we update our experience with conservative management of vestibular schwannomas.
  • STUDY DESIGN: Patients with intracanalicular and small/medium-sized tumors have been followed prospectively at a tertiary referral center.
  • METHODS: One hundred twenty-three patients affected by sporadic vestibular schwannoma were primarily observed by means of magnetic resonance imaging scans.
  • In case of significant tumor growth (> or =2 mm), patients were either surgically treated or submitted to radiotherapy, but, not rarely, they continued to follow the "wait-and-scan" policy.
  • Tumor-size changes over time were also evaluated with hearing function.
  • RESULTS: Almost two thirds (64.5%) of the cases did not show tumor growth during the entire period of observation (mean follow-up period, 4.8 yrs).
  • Among growing tumors, 16 patients were surgically treated with no complications or facial nerve palsy.
  • Less than half (45.5%) of the patients presented useful hearing (classes A and B of the American Academy of Otolaryngology-Head and Neck Surgery classification) at diagnosis, and 41 (73.2%) patients had preserved hearing during follow-up independently from the tumor growth rate.
  • CONCLUSIONS: Conservative management of vestibular schwannoma appears to be a safe procedure because most tumors do not grow and surgical outcomes are not affected by possible delays.
  • Because of the irregular behavior of the tumor, periodic neuroradiologic scans are mandatory to limit late surgical risks.
  • [MeSH-major] Ear Neoplasms / surgery. Neurilemmoma / surgery. Vestibule, Labyrinth

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  • (PMID = 18438269.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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78. Friedman WA: Linear accelerator radiosurgery for vestibular schwannomas. Prog Neurol Surg; 2008;21:228-37
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  • [Title] Linear accelerator radiosurgery for vestibular schwannomas.
  • The treatment paradigm uses the rotating high-energy X-ray output of the LINAC to focus many hundreds of 'beam equivalents' on intracranial or spinal targets.
  • At the University of Florida, 450 vestibular schwannomas have been treated.
  • Tumor control has been achieved in 90% (5- year actuarial data).
  • Since reducing the treatment dose to 1,250 cGy, in 1994, the incidence of facial and trigeminal nerve injury has been <1%.
  • No instance of malignant tumor transformation has been observed.
  • We believe that radiosurgery is the treatment of choice for smaller vestibular schwannomas.
  • [MeSH-major] Neuroma, Acoustic / surgery. Particle Accelerators / instrumentation. Radiosurgery / instrumentation

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  • (PMID = 18810224.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 22
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79. Doherty JK, Friedman RA: Controversies in building a management algorithm for vestibular schwannomas. Curr Opin Otolaryngol Head Neck Surg; 2006 Oct;14(5):305-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Controversies in building a management algorithm for vestibular schwannomas.
  • PURPOSE OF REVIEW: The present review examines the various mainstream treatment options, benefits and risks, and controversies involved in developing a management algorithm for treatment of vestibular schwannoma.
  • RECENT FINDINGS: Advances in microsurgery and radiosurgery have made tremendous contributions to management of vestibular schwannoma; however, considerable controversy still exists.
  • The auditory and facial nerve functional outcomes have improved with use of intraoperative monitoring for vestibular schwannoma removal and with lower radiosurgery doses; however, risks to the facial and auditory nerves still exist.
  • Observing vestibular schwannomas for growth with serial magnetic resonance imaging is an increasingly popular option for small vestibular schwannomas that allows patients to enjoy hearing and facial function.
  • SUMMARY: The risks and benefits of each treatment option must be weighed for each patient, and management decisions regarding vestibular schwannomas should be individualized for each patient depending on tumor anatomy, patient preferences, and symptoms.
  • [MeSH-major] Algorithms. Ear, Inner / surgery. Neuroma, Acoustic / therapy
  • [MeSH-minor] Cochlear Nerve / physiology. Facial Nerve / physiology. Hearing Loss / prevention & control. Humans. Magnetic Resonance Imaging. Microsurgery. Neurofibromatosis 2 / surgery. Neurofibromatosis 2 / therapy. Radiosurgery. Treatment Outcome

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  • [CommentIn] Curr Opin Otolaryngol Head Neck Surg. 2006 Oct;14(5):297-8 [16974140.001]
  • (PMID = 16974142.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 63
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80. Yomo S, Arkha Y, Delsanti C, Roche PH, Thomassin JM, Régis J: Repeat gamma knife surgery for regrowth of vestibular schwannomas. Neurosurgery; 2009 Jan;64(1):48-54; discussion 54-5
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  • [Title] Repeat gamma knife surgery for regrowth of vestibular schwannomas.
  • OBJECTIVE: Gamma knife surgery (GKS) has become established as a minimally invasive treatment modality for patients with vestibular schwannomas.
  • Treatment failure and/or tumor regrowth, however, is occasionally encountered, and microsurgical resection is usually warranted in such cases.
  • The goal of this study was to investigate whether repeat GKS is an effective treatment for recurrent vestibular schwannomas and to assess the conservation of residual neurological function.
  • METHODS: Between July 1992 and December 2007, 1951 patients harboring a unilateral vestibular schwannoma were treated with GKS.
  • Of these, 48 patients (2.5%) had to undergo a subsequent intervention because of progression or regrowth of the tumor.
  • Repeat GKS was performed in a total of 15 patients, 8 of whom had more than 2 years of follow-up and were eligible to be enrolled in the present study.
  • The median tumor volume was 0.51 and 1.28 mL at the initial and second GKS treatments, respectively.
  • Six patients demonstrated a significant reduction in tumor volume.
  • In 1 patient, the final tumor volume was less than the initial volume.
  • The other 2 patients showed stabilization of tumor growth.
  • Neither aggravation of facial nerve dysfunction nor other neurological deficits secondary to GKS were observed.
  • CONCLUSION: This is the first report to address repeat GKS for vestibular schwannomas.
  • After long-term follow-up, repeat GKS with a low marginal dose seems to be a safe and effective treatment in selected patients harboring regrowth of small vestibular schwannomas that have previously been treated with GKS.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 19050660.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Fukuda M, Oishi M, Kawaguchi T, Watanabe M, Takao T, Tanaka R, Fujii Y: Etiopathological factors related to hydrocephalus associated with vestibular schwannoma. Neurosurgery; 2007 Dec;61(6):1186-92; discussion 1192-3
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  • [Title] Etiopathological factors related to hydrocephalus associated with vestibular schwannoma.
  • OBJECTIVE: We retrospectively analyzed various clinical factors to determine whether or not these factors are etiopathologically related to the development of hydrocephalus in patients with vestibular schwannomas.
  • METHODS: There were 68 patients (29 men, 39 women) in this study who underwent resection of a vestibular schwannoma.
  • The maximum diameter of the tumor in the cerebellopontine cistern ranged from 0 (localized within the internal auditory canal) to 56 mm (mean, 32.0 +/- 12.9 mm).
  • Univariate analysis of various factors revealed that both tumor size and CSF protein concentration were positively related to development of hydrocephalus (P < 0.05 and P < 0.01, respectively).
  • There was a trend toward increased CSF protein concentration in patients with a large tumor (> or = 40 mm) compared with those with a small tumor (< 40 mm) (P = 0.06).
  • CONCLUSION: A high CSF protein concentration in fluid from the cerebellomedullary cistern is one of the most important factors contributing to hydrocephalus associated with vestibular schwannoma.
  • It is important to judge whether or not any further treatment is required for hydrocephalus, in addition to tumor resection, especially in patients with communicating hydrocephalus.
  • [MeSH-major] Brain Neoplasms / complications. Hydrocephalus / etiology. Hydrocephalus / pathology. Neuroma, Acoustic / complications


82. Roche PH, Ribeiro T, Khalil M, Soumare O, Thomassin JM, Pellet W: Recurrence of vestibular schwannomas after surgery. Prog Neurol Surg; 2008;21:89-92
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  • [Title] Recurrence of vestibular schwannomas after surgery.
  • The issue of recurrence of vestibular schwannomas is poorly studied by the surgical literature and is probably underestimated.
  • This long-term event is mainly due to regrowth of microfragments that have been left in the operative field along the course of the facial nerve or at the surface of the pons.
  • Management of recurrence depends on the tumor size and patient's condition.
  • Prospective long-term follow-up studies using serial MR imaging after radical removal should bring reliable data about the incidence of vestibular schwannoma recurrence.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Neuroma, Acoustic / surgery

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  • (PMID = 18810204.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 7
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83. Møller MN, Werther K, Nalla A, Stangerup SE, Thomsen J, Bøg-Hansen TC, Nielsen HJ, Cayé-Thomasen P: Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1. Laryngoscope; 2010 Apr;120(4):657-62
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  • [Title] Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1.
  • OBJECTIVES/HYPOTHESIS: Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis.
  • It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking.
  • This study targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1.
  • A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.
  • STUDY DESIGN: Prospective vestibular schwannoma tissue sampling for ELISA and immunohistochemical determination of MMP-2, MMP-9 and TIMP-1.
  • METHODS: Thirty-four patients with a sporadic, noncystic, vestibular schwannoma were selected prospectively.
  • Repeated, preoperative magnetic resonance imaging determined the tumor growth pattern.
  • Following translabyrinthine resection, an enzyme-linked immunosorbent assay was used for determination of the MMP-2, MMP-9, and TIMP-1 concentration in tumor sample homogenates.
  • Immunohistochemical labeling was performed in 12 randomly selected tumors.
  • RESULTS: : All tumor homogenates expressed measurable MMP-9, MMP-2, and TIMP-1.
  • Immunolabeling localized MMP-9 expression to the tumor cells, whereas MMP-2 and TIMP-1 was found interstitially.
  • A significant correlation existed between the concentration MMP-9 and absolute tumor growth rate, whereas a weak correlation occurred for the relative growth rate.
  • CONCLUSIONS: Vestibular schwannomas express MMP-2, MMP-9, and TIMP-1 and the tumor concentration of MMP-9 correlates with absolute tumor growth rate, but not with age, gender, symptom duration, or preoperative tumor size.
  • We conclude that MMP-9 appears to be involved in the growth of vestibular schwannomas.
  • [MeSH-major] Matrix Metalloproteinase 2 / biosynthesis. Matrix Metalloproteinase 9 / biosynthesis. Neovascularization, Pathologic / enzymology. Neuroma, Acoustic / blood supply. RNA, Neoplasm / genetics. Tissue Inhibitor of Metalloproteinase-1 / genetics
  • [MeSH-minor] Adult. Aged. Enzyme-Linked Immunosorbent Assay. Female. Follow-Up Studies. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Prospective Studies

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  • (PMID = 20205165.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Neoplasm; 0 / Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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84. Welling DB, Packer MD, Chang LS: Molecular studies of vestibular schwannomas: a review. Curr Opin Otolaryngol Head Neck Surg; 2007 Oct;15(5):341-6
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  • [Title] Molecular studies of vestibular schwannomas: a review.
  • PURPOSE OF REVIEW: To summarize advances in understanding the molecular biology of vestibular schwannomas over the past year.
  • RECENT FINDINGS: The role of the neurofibromatosis type 2 protein, denoted as merlin or schwannomin, in embryonic development, cellular adherence, and in cell proliferation has become better elucidated in the past year.
  • Likewise, the role of merlin in Schwann cell-axon interaction has been studied.
  • Neurofibromatosis type 2 screening guidelines for young patients with solitary vestibular schwannomas have been published.
  • The role of electromagnetic radiation via cellular and portable telephones as a predisposing factor to vestibular schwannoma formation has also been the topic of several studies.
  • [MeSH-major] Neuroma, Acoustic / genetics
  • [MeSH-minor] Animals. Cell Phones. Embryonic Development. Genetic Testing. Humans. Mutation. Neurofibromatosis 2 / genetics. Neurofibromin 2 / metabolism. Oligonucleotide Array Sequence Analysis

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  • (PMID = 17823551.001).
  • [ISSN] 1068-9508
  • [Journal-full-title] Current opinion in otolaryngology & head and neck surgery
  • [ISO-abbreviation] Curr Opin Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
  • [Number-of-references] 36
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85. Goddard JC, Oliver ER, Lambert PR: Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma. Otol Neurotol; 2010 Apr;31(3):473-7
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  • [Title] Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma.
  • OBJECTIVE: Evaluate the rate of cerebrospinal fluid (CSF) leak after translabyrinthine craniotomy for the removal of vestibular schwannoma and describe details of closure technique.
  • PATIENTS: All individuals undergoing translabyrinthine craniotomy for removal of vestibular schwannoma from January 2000 to October 2008.
  • INTERVENTION: Translabyrinthine craniotomy for removal of vestibular schwannoma with abdominal fat graft harvest and layered closure.
  • RESULTS: Sixty-one patients underwent translabyrinthine craniotomy for the removal of vestibular schwannoma during a 9-year period.
  • CONCLUSION: Successful wound closure and CSF leak prevention after translabyrinthine craniotomy for the removal of vestibular schwannomas do not require the creation of a facial recess, manipulation of the ossicles, direct Eustachian tube plugging, or the use of alloplastic space-occupying materials.
  • [MeSH-major] Cerebrospinal Fluid Otorrhea / prevention & control. Cerebrospinal Fluid Rhinorrhea / prevention & control. Craniotomy / adverse effects. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Vestibule, Labyrinth / surgery

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  • (PMID = 20084041.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. del Río L, Lassaletta L, Alfonso C, Sarriá MJ, Gavilán J: [Clinical tumoral size dissociation in acoustic neuroma: reality or measure distortion?]. Acta Otorrinolaringol Esp; 2006 Oct;57(8):345-9
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  • [Title] [Clinical tumoral size dissociation in acoustic neuroma: reality or measure distortion?].
  • [Transliterated title] Disociación clínica-tamaño tumoral en el neurinoma del acúistico: realidad o problema de medida?
  • INTRODUCTION: In this study we have analyzed (i) the audiometric frequencies more often affected in acoustic neuroma (AN), (ii) the percentage of patients presenting normal hearing and those with sudden hearing loss, (iii) if there is a correlation between tumor size and hearing loss, and (iv) the relationship between clinical and radiological parameters and audiological data.
  • RESULTS: The highest threshold in the tumor's ear was found at 8000 Hz, and the highest interaural difference at 4000 Hz.
  • No significant association was found between tumor size and hearing loss, preoperative facial palsy or Vth cranial nerve deficit.
  • There was a significant association between the degree of hearing loss and Vth cranial nerve deficit, and between hearing loss and preoperative facial palsy.
  • CONCLUSIONS: The association between hearing loss and Vth cranial nerve deficit, and between hearing loss and preoperative facial palsy is independent the size of the tumour.
  • [MeSH-major] Hearing Loss / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / pathology

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  • (PMID = 17117690.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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87. Gharabaghi A, Samii A, Koerbel A, Rosahl SK, Tatagiba M, Samii M: Preservation of function in vestibular schwannoma surgery. Neurosurgery; 2007 Feb;60(2 Suppl 1):ONS124-7; discussion ONS127-8
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  • [Title] Preservation of function in vestibular schwannoma surgery.
  • The management and surgical technique for microsurgical tumor removal of vestibular schwannomas (acoustic neuroma) with the suboccipital retrosigmoid approach and semi-sitting patient positioning is described.
  • An emphasis is placed on the preservation of auditory and facial nerve function with a stepwise description of the technical and operative nuances, including presurgical evaluation, positioning, anesthesiological and neurophysiological aspects, approach, microsurgical techniques, and postsurgical care.
  • [MeSH-major] Microsurgery / methods. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Otologic Surgical Procedures / methods

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  • (PMID = 17297374.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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88. Koerbel A, Gharabaghi A, Safavi-Abbasi S, Tatagiba M, Samii M: Evolution of vestibular schwannoma surgery: the long journey to current success. Neurosurg Focus; 2005 Apr 15;18(4):e10
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  • [Title] Evolution of vestibular schwannoma surgery: the long journey to current success.
  • The extraordinary improvement of patient outcome after surgical treatment for vestibular schwannomas is relatively recent and has occurred mainly over the last 30 years.
  • Whereas in the past the primary goal of vestibular schwannoma management was to preserve the patient's life, the objective in vestibular schwannoma treatment today is to preserve neurological function.
  • Long-term follow-up examinations show negligible recurrence rates, indicating that the aim of preservation of nerve function does not limit the completeness of tumor removal with modern neurosurgical techniques.
  • Despite these advances in preserving the anatomical integrity of, for example, the cochlear nerve, losses of function and even deafness may occur postoperatively in some cases.
  • In this article, the authors report in detail the developments achieved in vestibular schwannoma surgery and the great clinicians to whom these results can be credited.
  • [MeSH-major] Microsurgery / history. Neuroma, Acoustic / history. Neuroma, Acoustic / surgery. Neurosurgery / history. Neurosurgical Procedures / history. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Deafness / etiology. Deafness / prevention & control. Facial Nerve Injuries / etiology. Facial Nerve Injuries / prevention & control. History, 18th Century. History, 19th Century. History, 20th Century. Humans. Neoplasm Recurrence, Local / prevention & control. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / prevention & control. Vestibulocochlear Nerve Injuries

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  • (PMID = 15844862.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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89. Mick P, Westerberg BD, Ngo R, Akagami R: Growing vestibular schwannomas: what happens next? Otol Neurotol; 2009 Jan;30(1):101-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Growing vestibular schwannomas: what happens next?
  • OBJECTIVE: To determine the subsequent growth patterns in vestibular schwannomas shown to be growing on serial imaging.
  • PATIENTS: Patients with tumors that demonstrated growth of greater than 1 mm/yr between 2 consecutive scans (magnetic resonance or computed tomography) and had at least 1 follow-up scan were included.
  • MAIN OUTCOME MEASURE(S): Maximum dimension along the axis of the internal auditory canal was measured for intracanalicular tumors, whereas for extracanalicular tumors, maximal dimension along any orientation was used.
  • Of the growing tumors, 63.9% continued to grow, 30.6% stayed the same size, and 5.6% regressed in size.
  • CONCLUSION: Most vestibular schwannomas identified to be growing are likely to continue to grow on subsequent serial imaging.
  • These results are useful in clinical decision making and counseling patients with growing vestibular schwannomas.
  • [MeSH-major] Neuroma, Acoustic / pathology
  • [MeSH-minor] Cell Division. Ear Canal / pathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Patient Selection. Remission, Spontaneous. Tomography, X-Ray Computed

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  • (PMID = 19108071.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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90. Mohammed TA, Ahuja MS, Ju SS, Thomas J: Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma. J Postgrad Med; 2010 Jul-Sep;56(3):213-5
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  • [Title] Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma.
  • Vestibular schwannomas are not uncommon, and gamma knife radiosurgery is one of the treatment options for symptomatic tumors.
  • Hydrocephalus is a complication of gamma knife treatment of vestibular schwannoma, though the mechanism of the development of hydrocephalus remains controversial.
  • We present an unusual case of normal pressure hydrocephalus (NPH) after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of the hydrocephalus.
  • [MeSH-major] Hydrocephalus, Normal Pressure / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


91. Samii M, Gerganov V, Samii A: Hearing preservation after complete microsurgical removal in vestibular schwannomas. Prog Neurol Surg; 2008;21:136-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hearing preservation after complete microsurgical removal in vestibular schwannomas.
  • AIM: To evaluate and present the treatment strategy and hearing preservation in a recent series of vestibular schwannoma cases.
  • RESULTS: The anatomical integrity of the cochlear nerve was preserved in 75.8% of the cases.
  • It was highest in small tumors--60% in class T1 and 72% in class T2.
  • In tumors extending to and compressing the brain stem, preservation of some hearing was possible in up to 43%.
  • CONCLUSIONS: Vestibular schwannomas are benign lesions whose total removal leads to definitive healing of the patient.
  • Using the retrosigmoid approach with the patient in the semi-sitting position, hearing preservation is possible even for large schwannomas.
  • [MeSH-major] Hearing Loss / prevention & control. Microsurgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry. Cochlear Nerve / physiopathology. Cohort Studies. Humans. Middle Aged. Retrospective Studies. Treatment Outcome. Young Adult

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  • (PMID = 18810211.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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92. Chen L, Chen LH, Ling F, Liu YS, Samii M, Samii A: Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy. Chin Med J (Engl); 2010 Feb 5;123(3):274-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Removal of vestibular schwannoma and facial nerve preservation using small suboccipital retrosigmoid craniotomy.
  • BACKGROUND: Vestibular schwannoma, the commonest form of intracranial schwannoma, arises from the Schwann cells investing the vestibular nerve.
  • At present, the surgery for vestibular schwannoma remains one of the most complicated operations demanding for surgical skills in neurosurgery.
  • And the trend of minimal invasion should also be the major influence on the management of patients with vestibular schwannomas.
  • We summarized the microsurgical removal experience in a recent series of vestibular schwannomas and presented the operative technique and cranial nerve preservation in order to improve the rates of total tumor removal and facial nerve preservation.
  • METHODS: A retrospective analysis was performed in 145 patients over a 7-year period who suffered from vestibular schwannomas that had been microsurgically removed by suboccipital retrosigmoid transmeatus approach with small craniotomy.
  • CT thinner scans revealed the tumor size in the internal auditory meatus and the relationship of the posterior wall of the internal acoustic meatus to the bone labyrinths preoperatively.
  • Brain stem evoked potential was monitored intraoperatively.
  • The posterior wall of the internal acoustic meatus was designedly drilled off.
  • RESULTS: Total tumor resection was achieved in 140 cases (96.6%) and subtotal resection in 5 cases.
  • The anatomical integrity of the facial nerve was preserved in 91.0% (132/145) of the cases.
  • Intracranial end-to-end anastomosis of the facial nerve was performed in 7 cases.
  • Functional preservation of the facial nerve was achieved in 115 patients (Grade I and Grade II, 79.3%).
  • Preservation of nerves and vessels were as important as tumor removal during the operation.
  • CT thinner scan could show the relationship between the posterior wall of the internal acoustic meatus and bone labyrinths, that is helpful for a safe drilling of the posterior wall of the internal acoustic meatus.
  • Using the retrosigmoid approach with small craniotomy is possible even for large schwannomas.
  • Knowing the microanatomy of the cerebellopontine angle and internal auditory meatus, intraoperating neurophysiological monitoring of the facial nerve function, and the microsurgical techniques of the surgeons are all important factors for improving total tumor removal and preserving facial nerve function.
  • [MeSH-major] Craniotomy / methods. Facial Nerve / surgery. Neuroma, Acoustic / surgery

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  • (PMID = 20193244.001).
  • [ISSN] 0366-6999
  • [Journal-full-title] Chinese medical journal
  • [ISO-abbreviation] Chin. Med. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
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93. Slattery WH 3rd: Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas. Otolaryngol Clin North Am; 2009 Aug;42(4):707-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas.
  • Radiosurgery or radiotherapy for vestibular schwannomas has become a common practice with a high chance for tumor control.
  • Despite the high rate of tumor control, there are some tumors that cannot be controlled with radiation therapy.
  • Surgical treatment after radiosurgery or radiotherapy may be necessary for tumors that continue to grow, or for patients who develop brainstem compressive symptoms, disabling hemifacial spasm, or hydrocephalus.
  • The House Ear Clinic (Los Angeles, California) experience with microsurgery after irradiation has demonstrated that the facial nerve is different once it has been radiated.
  • An irradiated facial nerve's regeneration potential is diminished, and the recovery from microsurgical trauma is not as robust.
  • [MeSH-major] Microsurgery / methods. Neoplasm Invasiveness / pathology. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Combined Modality Therapy. Cranial Irradiation / methods. Dose-Response Relationship, Radiation. Female. Humans. Male. Neoadjuvant Therapy. Neoplasm Staging. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Prognosis. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751874.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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94. Nicoucar K, Momjian S, Vader JP, De Tribolet N: Surgery for large vestibular schwannomas: how patients and surgeons perceive quality of life. J Neurosurg; 2006 Aug;105(2):205-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery for large vestibular schwannomas: how patients and surgeons perceive quality of life.
  • OBJECT: The aim of this study was to assess the consequences of total removal of a large vestibular schwannoma on the patient's symptoms and quality of life (QOL).
  • METHODS: A questionnaire regarding preoperative and postoperative symptoms with measures of both daily and global QOL and a modified 36-Item Short Form Health Survey (SF-36) QOL instrument were sent to 103 patients who had undergone surgery via a retrosigmoid approach for total removal of a Grade III or IV vestibular schwannoma.
  • Forty-six (64%) of the schwannomas were Grade IV and 26 (36%) were Grade III.
  • Patients with large vestibular schwannomas had lower scores in all SF-36 categories except pain compared with data from other studies.
  • CONCLUSIONS: Surgery for a large vestibular schwannoma has a significant impact on the patient's QOL.
  • [MeSH-major] Attitude of Health Personnel. Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life / psychology

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  • (PMID = 17219824.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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95. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102 Suppl:195-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm3.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Female. Follow-Up Studies. Hearing Disorders / diagnosis. Hearing Disorders / etiology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging. Radiation Dosage. Severity of Illness Index. Trigeminal Neuralgia / etiology. Tumor Burden / radiation effects

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  • (PMID = 15662809.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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96. Silk PS, Lane JI, Driscoll CL: Surgical approaches to vestibular schwannomas: what the radiologist needs to know. Radiographics; 2009 Nov;29(7):1955-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches to vestibular schwannomas: what the radiologist needs to know.
  • Vestibular schwannomas account for 85% of cerebellopontine angle tumors in adults and most commonly arise from the inferior division of the vestibular nerve.
  • Three main surgical techniques are currently being used for the removal of vestibular schwannomas: middle cranial fossa, suboccipital, and translabyrinthine approaches.
  • A good understanding of the main surgical approaches, relevant anatomic considerations, surgical complications, and likelihood of tumor recurrence is essential for interpreting magnetic resonance images to the advantage of both the surgeon and the patient, particularly when hearing preservation is a consideration.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods. Surgery, Computer-Assisted / methods. Tomography, X-Ray Computed / methods

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  • (PMID = 19926756.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Lassaletta L, Bello MJ, Del Río L, Alfonso C, Roda JM, Rey JA, Gavilan J: DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings. Otol Neurotol; 2006 Dec;27(8):1180-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA methylation of multiple genes in vestibular schwannoma: Relationship with clinical and radiological findings.
  • HYPOTHESIS: The purpose of this study was to examine the DNA methylation profile of several genes in a series of vestibular schwannomas, and to analyze its relationship with clinical and radiological features.
  • BACKGROUND: Aberrant methylation of promoter regions is a major mechanism for silencing of tumor suppressor genes in several tumors.
  • There is limited information about methylation status in vestibular schwannoma, with no clinical or radiological implications described to date.
  • METHODS: The methylation status of 16 tumor-related genes including RASSF1A, RAR-B, VHL, PTEN, HMLH1, RB1, TP16, CASP8, ER, TIMP3, MGMT, DAPK, TP73, GSTP1, TP14, and THBS1 was examined in a series of 22 vestibular schwannomas.The bisulfite modification of genomic DNA was performed.
  • Methylation of CASP8 was associated with the patient's age and the tumor size.
  • CONCLUSION: Aberrant methylation of tumor-related genes may play a role in the development of vestibular schwannomas.
  • Our results may provide useful clues to the development of prognostic assays for these tumors.
  • [MeSH-major] DNA Methylation. Neuroma, Acoustic / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Auditory Threshold / physiology. Female. Genes, Tumor Suppressor / physiology. Hearing Loss / genetics. Humans. Male. Middle Aged. Promoter Regions, Genetic / genetics


98. Mandl ES, Vandertop WP, Meijer OW, Peerdeman SM: Imaging-documented repeated intratumoral hemorrhage in vestibular schwannoma: a case report. Acta Neurochir (Wien); 2009 Oct;151(10):1325-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging-documented repeated intratumoral hemorrhage in vestibular schwannoma: a case report.
  • Intratumoral hemorrhage in vestibular schwannomas is rare.
  • Intratumoral hemorrhage is probably caused by vascular fragility associated with tumor characteristics and growth.
  • The present report details the case of acute neurological deterioration in a patient with repeated intratumoral hemorrhage inside a vestibular schwannoma with computed tomography and magnetic resonance imaging confirmation.
  • To our knowledge, repeated hemorrhage in vestibular schwannoma with radiological confirmation has not been reported before.
  • [MeSH-major] Cerebellopontine Angle / pathology. Intracranial Hemorrhages / diagnosis. Intracranial Hemorrhages / etiology. Neuroma, Acoustic / complications. Neuroma, Acoustic / diagnosis. Vestibular Nerve / pathology
  • [MeSH-minor] Disease Progression. Facial Nerve Injuries / etiology. Female. Humans. Hydrocephalus / etiology. Hydrocephalus / pathology. Hydrocephalus / surgery. Magnetic Resonance Imaging. Middle Aged. Neurosurgical Procedures. Postoperative Complications. Radiotherapy. Tomography, X-Ray Computed. Treatment Outcome. Ventriculoperitoneal Shunt

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  • [Cites] Neurosurgery. 2003 Aug;53(2):282-87; discussion 287-8 [12925242.001]
  • [Cites] Clin Neurol Neurosurg. 1998 Mar;100(1):68-74 [9637211.001]
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  • (PMID = 19255715.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Other-IDs] NLM/ PMC2760714
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99. Huang CF, Tu HT, Lo HK, Wang KL, Liu WS: Radiosurgery for vestibular schwannomas. J Chin Med Assoc; 2005 Jul;68(7):315-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery for vestibular schwannomas.
  • We report our experience with radiosurgery for tumor control and the complications of unilateral vestibular schwannomas.
  • METHODS: We reviewed our early experience regarding clinical presentation, management and outcomes in 45 patients with acoustic schwannomas who underwent gamma knife stereotactic radiosurgery.
  • Median tumor volume was 4.5 mL (range, 0.5-30.0), and median radiotherapy dose was 11.5 Gy (range, 10.5-14.0 Gy).
  • RESULTS: Tumor control was achieved in 43 patients (95.6%).
  • Reduction in tumor size was shown in 15 patients (33.3%).
  • No patients had delayed facial palsy or lower cranial nerve dysfunction, but one had delayed trigeminal sensory loss.
  • CONCLUSION: Radiosurgery achieved a high tumor control rate and a relatively low post-radiosurgical complication rate for acoustic neuromas.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 16038371.001).
  • [ISSN] 1726-4901
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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100. Cauley KA, Ratkovits B, Braff SP, Linnell G: Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study. AJNR Am J Neuroradiol; 2009 May;30(5):992-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study.
  • Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors.
  • Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause hydrocephalus without treatment.
  • We present an MR imaging study of an unusual case of communicating hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of hydrocephalus.
  • [MeSH-major] Hydrocephalus / etiology. Hydrocephalus / pathology. Magnetic Resonance Imaging / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects






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