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1. Sahu RN, Mehrotra N, Tyagi I, Banerji D, Jain VK, Behari S: Management strategies for bilateral vestibular schwannomas. J Clin Neurosci; 2007 Aug;14(8):715-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management strategies for bilateral vestibular schwannomas.
  • BACKGROUND: Bilateral vestibular schwannomas (VS) are rare.
  • Most patients in India present late in the course of illness with large tumors and disabling deafness.
  • AIMS: To highlight the differences in clinical presentations and surgical results of bilateral VS compared to unilateral VS; and, to propose a management strategy for these tumors with reference to tumor size, extent of growth and the presence or absence of hearing impairment.
  • Assessment of VIIth and VIIIth cranial nerve function, tumor size, volume and extent of growth was performed in all patients.
  • The management strategy was based on Samii's classification of tumor extent.
  • Headache with features of raised intracranial pressure were present in 10 (62.5%) patients.
  • Giant tumors were present in seven (43.7%) patients; large tumors in eight (50%) and a medium-sized tumor in one (6.3%).
  • Total tumor resection was achieved in 13 patients and subtotal resection in two.
  • On the contralateral side, one large tumor required total excision.
  • One medium sized tumor underwent sub-capsular excision in an attempt to preserve hearing.
  • The facial nerve was anatomically preserved in seven (46.7%) patients and in one, the cochlear nerve was anatomically preserved.
  • CONCLUSIONS: Patients with bilateral schwannomas are younger, have larger lesions, poorer preoperative hearing and are more likely to lose either auditory and/or facial nerve function during attempted total resection of the tumor.
  • Classifying the tumors into two groups by extent, that is, tumors extending to the cerebellopontine angle cistern (T1-T3a) and, tumors extending to or compressing the brainstem (T3b to T4b), allows the surgical strategy to be defined.
  • [MeSH-major] Cranial Nerve Neoplasms / therapy. Functional Laterality. Neuroma, Acoustic / therapy
  • [MeSH-minor] Adult. Cranial Nerves / physiopathology. Female. Hearing Disorders / etiology. Humans. Intracranial Pressure / physiology. Longitudinal Studies. Magnetic Resonance Imaging / methods. Male. Retrospective Studies. Tomography, X-Ray Computed / methods

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  • (PMID = 17577524.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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2. Yomo S, Tamura M, Carron R, Porcheron D, Régis J: A quantitative comparison of radiosurgical treatment parameters in vestibular schwannomas: the Leksell Gamma Knife Perfexion versus Model 4C. Acta Neurochir (Wien); 2010 Jan;152(1):47-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A quantitative comparison of radiosurgical treatment parameters in vestibular schwannomas: the Leksell Gamma Knife Perfexion versus Model 4C.
  • The aim of this study was to investigate the impact of the PFX technology on the quality of dose planning for vestibular schwannomas (VS).
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / instrumentation

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  • (PMID = 19809786.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial
  • [Publication-country] Austria
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3. Mahrous AK, Kalepu R: Positive findings on MRI in patients with asymmetrical SNHL. Eur Arch Otorhinolaryngol; 2008 Dec;265(12):1471-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The pickup rate was 1% for CPA lesion which was vestibular schwannoma.

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  • (PMID = 18478244.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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4. McClelland S 3rd, Gerbi BJ, Higgins PD, Orner JB, Hall WA: Safety and efficacy of fractionated stereotactic radiotherapy for acoustic neuromas. J Neurooncol; 2008 Jan;86(2):191-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Safety and efficacy of fractionated stereotactic radiotherapy for acoustic neuromas.
  • BACKGROUND: The treatment of acoustic neuromas (AN) has historically involved surgical excision or stereotactic radiosurgery, with a relatively limited number of reports available describing the use of fractionated stereotactic radiotherapy (FSRT).
  • Median tumor size (maximum diameter) was 2.1 cm (range, 1.1-3.4 cm).
  • RESULTS: Following FSRT, local tumor control was achieved in every patient, with the treatment well-tolerated by all patients.
  • No patient experienced acute complications or facial nerve weakness.
  • Two patients experienced permanent trigeminal nerve morbidity manifesting as facial numbness.
  • CONCLUSION: In our series of 20 patients with AN, all had local tumor control following FSRT, with minimal morbidity.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Stereotaxic Techniques
  • [MeSH-minor] Adult. Aged. Dose Fractionation. Female. Follow-Up Studies. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiography. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / surgery

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  • (PMID = 17622486.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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5. Rajaraman P, Schwartz BS, Rothman N, Yeager M, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD: Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults. Environ Health Perspect; 2005 Sep;113(9):1209-11
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  • [Title] Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults.
  • The enzyme delta-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis, can be inhibited by several chemicals, including lead, a potential risk factor for brain tumors, particularly meningioma.
  • In this study we examined whether the ALAD G177C polymorphism in the gene coding for ALAD is associated with risk of intracranial tumors of the brain and nervous system.
  • We use data from a case-control study with 782 incident brain tumor cases and 799 controls frequency matched on hospital, age, sex, race/ethnicity, and residential proximity to the hospital.
  • ALAD genotype was determined for 94% of these samples (355 glioma, 151 meningioma, 67 acoustic neuroma, and 505 controls).
  • No increased risk associated with the ALAD2 variant was observed for glioma or acoustic neuroma.
  • [MeSH-major] Brain Neoplasms / genetics. Genetic Predisposition to Disease. Meningioma / genetics. Porphobilinogen Synthase / genetics

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  • (PMID = 16140629.001).
  • [ISSN] 0091-6765
  • [Journal-full-title] Environmental health perspectives
  • [ISO-abbreviation] Environ. Health Perspect.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 4.2.1.24 / Porphobilinogen Synthase
  • [Other-IDs] NLM/ PMC1280403
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6. Schwarz C, Dang Burgener NP, Dosso AA: [OCT Visante observation of the progression of a perforated neurotrophic cornea ulcer treated with amniotic membrane grafts]. J Fr Ophtalmol; 2008 Apr;31(4):419-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Observation à l'OCT Visante de l'évolution d'un ulcère cornéen neurotrophique perforant traité par greffes de membranes amniotiques.
  • METHODS: A 71-year-old patient with facial nerve paresis secondary to vestibular schwannoma surgery presented with a neurotrophic perforated corneal ulcer.
  • [MeSH-minor] Aged. Disease Progression. Humans. Male

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  • (PMID = 18563043.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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7. Cauley KA, Ratkovits B, Braff SP, Linnell G: Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study. AJNR Am J Neuroradiol; 2009 May;30(5):992-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Communicating hydrocephalus after gamma knife radiosurgery for vestibular schwannoma: an MR imaging study.
  • Vestibular schwannomas are common, and gamma knife radiosurgery is a treatment option of symptomatic tumors.
  • Hydrocephalus may be a complication of gamma knife treatment of vestibular schwannoma, though the cause-and-effect relationship can be debated because tumors can cause hydrocephalus without treatment.
  • We present an MR imaging study of an unusual case of communicating hydrocephalus after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of hydrocephalus.
  • [MeSH-major] Hydrocephalus / etiology. Hydrocephalus / pathology. Magnetic Resonance Imaging / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


8. Godefroy WP, van der Mey AG, de Bruine FT, Hoekstra ER, Malessy MJ: Surgery for large vestibular schwannoma: residual tumor and outcome. Otol Neurotol; 2009 Aug;30(5):629-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery for large vestibular schwannoma: residual tumor and outcome.
  • OBJECTIVE: To evaluate clinical outcome with regard to the amount of residual tumor after surgery for large vestibular schwannoma.
  • PATIENTS: Between January 2000 and December 2005, 51 large vestibular schwannoma tumors with extrameatal diameter of 2.6 cm or greater (mean, 32 mm; median, 30 mm; range, 26-50 mm) were operated using the translabyrinthine approach.
  • The amount of residual tumor was measured, and the shape and localization was scored on gadolinium-enhanced magnetic resonance imaging (MRI).
  • Potential growth of residual tumor was documented with frequent MRI follow-up.
  • Postoperative facial nerve function was classified according to the House-Brackmann classification.
  • Magnetic resonance imaging showed residual tumor in 46% of patients (mean, 16.7 mm; SD, +/-8, range, 5-36 mm).
  • Postoperative facial nerve function was House-Brackmann Grades I to II in 78% of the patients.
  • Postoperative MRI showed either no residual tumor or residue that should actually have been classified as a subtotal resection.
  • CONCLUSION: Tumor control with good facial nerve function could be obtained in most patients.
  • Intraoperative assessment did not correlate with the amount of residual tumor on postoperative MRI.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures
  • [MeSH-minor] Adult. Aged. Facial Nerve / pathology. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Postoperative Complications / epidemiology. Treatment Outcome. Young Adult

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  • (PMID = 19471168.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Fortnum H, O'Neill C, Taylor R, Lenthall R, Nikolopoulos T, Lightfoot G, O'Donoghue G, Mason S, Baguley D, Jones H, Mulvaney C: The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history. Health Technol Assess; 2009 Mar;13(18):iii-iv, ix-xi, 1-154
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history.
  • OBJECTIVE(S): To evaluate the clinical effectiveness and cost-effectiveness of a range of diagnostic strategies for investigating patients with unilateral hearing loss and/or tinnitus, with a view to confirming or eliminating a diagnosis of acoustic neuroma, and to describe the natural history of acoustic neuroma.
  • ABR has high sensitivity compared with MR imaging for acoustic neuromas greater than 1 cm in size but not for smaller neuromas.
  • Non-contrast-enhanced MR imaging was found to be a more cost-effective test for acoustic neuroma than GdT1W MR imaging.
  • The incidence of acoustic neuroma has increased over the last 30 years, with the median age at diagnosis remaining at 55 years.
  • The pattern and rate of growth of acoustic neuroma are highly variable and currently unpredictable.
  • Given the recent improvement in resolution and reduction in cost of MR imaging, ABR can no longer be considered appropriate as the primary test used to screen for acoustic neuroma.
  • Based on a cost-effectiveness model developed to reflect UK practice it was concluded that a diagnostic algorithm that deploys non-contrast MR imaging as an initial imaging screen in the investigation of acoustic neuroma is less costly than and likely to be as effective as available contrast MR imaging.
  • [MeSH-major] Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / economics
  • [MeSH-minor] Age Distribution. Cost-Benefit Analysis. Evoked Potentials, Auditory, Brain Stem. Hearing Tests. Humans. Incidence. Magnetic Resonance Imaging. Prevalence. Reproducibility of Results. Technology Assessment, Biomedical

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  • (PMID = 19358774.001).
  • [ISSN] 2046-4924
  • [Journal-full-title] Health technology assessment (Winchester, England)
  • [ISO-abbreviation] Health Technol Assess
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 244
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10. Demetriades AK, Saunders N, Rose P, Fisher C, Rowe J, Tranter R, Hardwidge C: Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery. Skull Base; 2010 Sep;20(5):381-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of acoustic neuroma/vestibular schwannoma 10 years after gamma knife stereotactic radiosurgery.
  • Only a handful of cases of de-novo malignancies of the vestibulocochlear nerve have been reported.
  • Even rarer is the malignant transformation of a previously histologically diagnosed benign vestibular schwannoma.
  • We present the case of a young adult who had combined operative/Gamma knife treatment for a benign vestibular schwannoma, followed by further surgery 2 years later.
  • He represented 10 years after original diagnosis with facial numbness and ataxia, MRI showing gross tumor recurrence.
  • After radical resection, histology showed malignant transformation to a malignant peripheral nerve sheath tumor.
  • Histology confirmed further de-differentiation to an anaplastic sarcoma.
  • While awaiting radiotherapy the tumor recurred again, the patient succumbing.
  • In the literature there are 13 other cases of malignant vestibular schwannomata.
  • The tumor biology of vestibular schwannomata as well as the radiobiology in the context of malignant transformation is discussed.

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  • [Cites] Nucleic Acids Res. 1983 Oct 25;11(20):7191-203 [6634412.001]
  • (PMID = 21359005.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3023338
  • [Keywords] NOTNLM ; Gamma knife radiosurgery / Vestibular schwannoma / acoustic neuroma / anaplastic sarcoma / malignant peripheral nerve sheath tumor (MPNST) / malignant transformation / radiotherapy
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11. Sakai T, Vallejo MC, Shannon KT: A parturient with neurofibromatosis type 2: anesthetic and obstetric considerations for delivery. Int J Obstet Anesth; 2005 Oct;14(4):332-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis type 2 is an extremely rare form of neurofibromatosis characterized by central nervous system involvement with bilateral vestibular schwannomas and spinal tumors.
  • Anesthetic management of a parturient with neurofibromatosis type 2 has not been fully reported, and the condition is challenging to obstetric anesthesiologists due to the presence of intracranial and intraspinal canal neurofibromas.


12. Springborg JB, Poulsgaard L, Thomsen J: Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines. Skull Base; 2008 Jul;18(4):217-27
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonvestibular schwannoma tumors in the cerebellopontine angle: a structured approach and management guidelines.
  • The most common cerebellopontine angle (CPA) tumor is a vestibular schwannoma, but one in five CPA tumors are not vestibular schwannomas.
  • These tumors may require different management strategies.
  • Compared with vestibular schwannomas, symptoms and signs from cranial nerve VIII are less frequent: other cranial nerve and cerebellar symptoms and signs predominate in patients with these less common CPA tumors.
  • This review provides a structured approach to the diagnosis of nonvestibular schwannoma CPA lesions and also management guidelines.

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  • (PMID = 19119337.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2467479
  • [Keywords] NOTNLM ; Cerebellopontine angle / epidermoids / management guidelines / meningiomas / tumors
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13. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):589-609, ix-x
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  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / etiology. Headache / epidemiology. Headache / etiology. Humans. Meningitis / epidemiology. Meningitis / etiology. Neoplasm Recurrence, Local. Postoperative Complications. Postural Balance / physiology. Tinnitus / epidemiology. Tinnitus / etiology

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  • (PMID = 17544697.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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14. Karampelas I, Alberico RA, Plunkett RJ, Fenstermaker RA: Intratumoral hemorrhage after remote subtotal microsurgical resection and gamma knife radiosurgery for vestibular schwannoma. Acta Neurochir (Wien); 2007 Mar;149(3):313-6; discussion 316-7
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  • [Title] Intratumoral hemorrhage after remote subtotal microsurgical resection and gamma knife radiosurgery for vestibular schwannoma.
  • Our report describes the occurrence of intratumoral hemorrhage in a vestibular schwannoma, which was treated with microsurgical resection thirteen years and gamma knife surgery (GKS) more than two years prior to the event.
  • Although rare, it is apparent that bleeding into a vestibular schwannoma remains a possibility, even after the tumor has responded favorably to GKS.
  • Long-term followup of patients with vestibular schwannoma who have been treated with GKS is advisable to assess treatment response and to detect adverse events (e.g. hemorrhage) suspected on clinical grounds.
  • [MeSH-major] Cerebral Hemorrhage / diagnosis. Microsurgery. Neuroma, Acoustic / surgery. Postoperative Hemorrhage / diagnosis. Radiosurgery
  • [MeSH-minor] Cerebellopontine Angle / pathology. Follow-Up Studies. Hemosiderin / metabolism. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm, Residual / diagnosis

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  • (PMID = 17273886.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
  • [Chemical-registry-number] 9011-92-1 / Hemosiderin
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15. Kiratli H, Yildiz S, Soylemezoğlu F: Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. Orbit; 2008;27(6):451-4
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  • [Title] Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other.
  • A highly unusual patient with neurofibromatosis type 2 (NF2) presenting with simultaneous bilateral orbital tumors is described.
  • Magnetic resonance imaging studies showed bilateral cerebellopontine angle tumors, a tumor surrounding the right intraorbital optic nerve, and a large left lateral orbital mass mixed with the lateral rectus muscle.
  • The histopathological diagnoses following incisional biopsies were right optic nerve sheath meningioma and left intramuscular schwannoma.
  • The left-sided orbital schwannoma and the right-sided vestibular schwannoma were treated with fractionated stereotactic radiotherapy.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Muscle Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neurilemmoma / pathology. Neurofibromatosis 2 / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Functional Laterality. Hamartoma / pathology. Humans. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Neuroma, Acoustic / chemistry. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Oculomotor Muscles / pathology. Radiosurgery. Radiotherapy, Conformal. Retinal Diseases / pathology


16. Chen S, Xu Y, Ou Y, Zheng Y, Deng Y, Chen B: [Endoscope-assisted surgical resection of acoustic neuroma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Aug;22(16):729-31
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  • [Title] [Endoscope-assisted surgical resection of acoustic neuroma].
  • OBJECTIVE: To explore the therapeutic efficacy and complications of endoscope-assisted surgical resection of acoustic neuroma.
  • METHOD: Assisted by hard-tube ear endoscope, 11 patients with acoustic neuroma were operated via labyrinthine approach and retrosigmoid approach.
  • CONCLUSION: The application of ear endoscope in acoustic neuroma surgery can improve the total removal rate of tumors and the salvage rate of vessels and nerves.
  • [MeSH-major] Endoscopy. Neuroma, Acoustic / surgery

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  • (PMID = 18975773.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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17. Menon G, Nair S, Sudhir J, Rao BR, Mathew A, Bahuleyan B: Childhood and adolescent meningiomas: a report of 38 cases and review of literature. Acta Neurochir (Wien); 2009 Mar;151(3):239-44; discussion 244
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  • Eleven children (28.9%) had evidence of NF of whom three had NF2 with bilateral vestibular schwannomas.
  • The common presenting symptoms were seizures (76.3%), raised intracranial tension (71%), and focal neurological deficits (39.4%).
  • The location of the operated tumours were as follows: ten skull base (24.4%), ten falx/parasagittal (24.4%), eight spinal (19.5%), five convexity (12.2%), three posterior fossa (7.3%), three intraventricular (7.3%) and two optic nerve sheath (4.9%).
  • [MeSH-minor] Adolescent. Age Factors. Child. Comorbidity. Dura Mater / pathology. Dura Mater / surgery. Female. Humans. Intracranial Hypertension / etiology. Male. Neoplasm Recurrence, Local / epidemiology. Neuroma, Acoustic / epidemiology. Neurosurgical Procedures. Optic Nerve / pathology. Retrospective Studies. Seizures / etiology. Skull Base Neoplasms / epidemiology. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Spinal Neoplasms / epidemiology. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19238320.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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18. Arriaga MA, Chen DA, Burke EL: Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update. Otol Neurotol; 2007 Jun;28(4):538-40
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  • [Title] Hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma surgery-update.
  • OBJECTIVE: To update the outcome of hydroxyapatite cement cranioplasty in translabyrinthine acoustic neuroma (TLAN) surgery.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, Inner / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures

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  • (PMID = 17414174.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biocompatible Materials; 0 / Bone Cements; 91D9GV0Z28 / Durapatite
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19. Khrais T, Sanna M: Hearing preservation surgery in vestibular schwannoma. J Laryngol Otol; 2006 May;120(5):366-70
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  • [Title] Hearing preservation surgery in vestibular schwannoma.
  • OBJECTIVES: To study the effect of pre-operative hearing level and tumour size on the hearing outcome of hearing preservation surgery for vestibular schwannoma.
  • RESULTS: A total of 1993 patients in 16 publications addressing the topic of hearing preservation surgery in vestibular schwannoma were analysed.
  • [MeSH-major] Hearing. Neuroma, Acoustic / surgery

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  • (PMID = 16556349.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 27
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20. Hadfield KD, Smith MJ, Urquhart JE, Wallace AJ, Bowers NL, King AT, Rutherford SA, Trump D, Newman WG, Evans DG: Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas. Oncogene; 2010 Nov 25;29(47):6216-21
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  • [Title] Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas.
  • Biallelic inactivation of the NF2 gene occurs in the majority of schwannomas.
  • We have performed DNA sequence and dosage analysis of the NF2 gene in a panel of 239 schwannoma tumours: 97 neurofibromatosis type 2 (NF2)-related schwannomas, 104 sporadic vestibular schwannomas (VS) and 38 schwannomatosis-related schwannomas.
  • LOH was present in 28 out of 34 (82%) schwannomatosis-related schwannomas.
  • This study shows that MR is a mechanism of LOH in NF2 and SMARCB1-negative schwannomatosis-related schwannomas, occurring less frequently in sporadic vs. We found no evidence of MR in SMARCB1-positive schwannomatosis, suggesting that susceptibility to MR varies according to the disease context.
  • [MeSH-minor] Adolescent. Adult. Child. Chromosome Breakpoints. Gene Dosage / genetics. Genes, Neurofibromatosis 2. Homozygote. Humans. Neurilemmoma / genetics. Neurofibromatoses / genetics. Polymorphism, Single Nucleotide / genetics. Skin Neoplasms / genetics. Young Adult

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  • (PMID = 20729918.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] Schwannomatosis
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21. Koerbel A, Gharabaghi A, Samii A, Gerganov V, von Gösseln H, Tatagiba M, Samii M: Trigeminocardiac reflex during skull base surgery: mechanism and management. Acta Neurochir (Wien); 2005 Jul;147(7):727-32; discussion 732-3
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  • This phenomenon was defined as the onset of bradycardia lower than 60 beats/minute and hypotension with a drop in mean arterial blood pressure of 20% or more due to intra-operative manipulation or traction on the trigeminal nerve.
  • FINDINGS: Sixteen patients (8%) had a TCR intra-operatively (7 vestibular schwannomas, 5 sphenoid wing meningiomas, 3 petroclival meningiomas, 1 intracavernous epidermoid cyst).
  • CONCLUSIONS: Due to the intracranial course of the trigeminal nerve several surgical procedures at the anterior, middle and posterior skull base may elicit the trigeminocardiac reflex.
  • [MeSH-major] Bradycardia / physiopathology. Electrocardiography. Heart / innervation. Hypotension / physiopathology. Intraoperative Complications / physiopathology. Reflex, Oculocardiac / physiology. Skull Base / surgery. Skull Base Neoplasms / surgery. Trigeminal Nerve / physiopathology
  • [MeSH-minor] Adult. Aged. Cavernous Sinus / surgery. Craniotomy. Epidermal Cyst / surgery. Female. Heart Rate / physiology. Humans. Male. Meningeal Neoplasms / surgery. Meningioma / surgery. Middle Aged. Monitoring, Intraoperative. Neuroma, Acoustic / surgery

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  • (PMID = 15889318.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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22. Ozgen B, Oguz B, Dolgun A: Diagnostic accuracy of the constructive interference in steady state sequence alone for follow-up imaging of vestibular schwannomas. AJNR Am J Neuroradiol; 2009 May;30(5):985-91
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  • [Title] Diagnostic accuracy of the constructive interference in steady state sequence alone for follow-up imaging of vestibular schwannomas.
  • BACKGROUND AND PURPOSE: Vestibular schwannoma (VS) is a benign, slow-growing tumor, and radiologic monitoring is an acceptable alternative to surgery in small lesions and in elderly patients.
  • CONCLUSIONS: Noncontrast CISS-only technique may be a viable alternative to routine contrast-enhanced sequences for the follow-up of overall lesion size in patients with VS; however, treatment-related changes internal to the tumor are less noticeable using the CISS sequence.
  • [MeSH-major] Algorithms. Image Interpretation, Computer-Assisted / methods. Magnetic Resonance Imaging / methods. Neuroma, Acoustic / diagnosis

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  • (PMID = 19193761.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Chung SJ, Im JH, Lee JH, Cho AH, Kwon M, Lee MC: Isolated tongue tremor after gamma knife radiosurgery for acoustic schwannoma. Mov Disord; 2005 Jan;20(1):108-11
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  • [Title] Isolated tongue tremor after gamma knife radiosurgery for acoustic schwannoma.
  • We describe a patient who had an isolated tongue tremor with an audible click after gamma knife radiosurgery for acoustic schwannoma.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / adverse effects. Tongue Diseases / etiology. Tremor / etiology

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  • [Copyright] (c) 2004 Movement Disorder Society.
  • (PMID = 15390040.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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24. Slattery WH 3rd, Fisher LM, Hitselberger W, Friedman RA, Brackmann DE: Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients. J Neurosurg; 2007 Apr;106(4 Suppl):255-60
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  • [Title] Hearing preservation surgery for neurofibromatosis Type 2-related vestibular schwannoma in pediatric patients.
  • OBJECT: The authors reviewed the proportion of pediatric patients with neurofibromatosis Type 2 (NF2) in whom hearing was preserved after middle fossa resection of vestibular schwannoma (VS).
  • Speech discrimination scores (SDSs) and pre- and postfacial nerve grades were also recorded.
  • Facial nerve function was good (House-Brackmann Grades I or II) in 81% of the patients.
  • [MeSH-major] Facial Nerve / physiopathology. Hearing / physiology. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery


25. Stojicic MT, Slavik EE, Acimovic GT, Jovanovic MD, Stojmirovic DM, Vujotic LD: Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report. J Plast Reconstr Aesthet Surg; 2008 Nov;61(11):e9-11
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  • [Title] Simultaneous surgical treatment of ulcer terebrans with intracranial propagation and acoustic neurinoma on the same side: a case report.
  • This article presents a successful surgical treatment of the patient with aggressive basal cell carcinoma with intracranial propagation (ulcer terebrans) and simultaneous acoustic neurinoma on the same side.
  • [MeSH-major] Carcinoma, Basal Cell / surgery. Neoplasms, Multiple Primary / surgery. Neuroma, Acoustic / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Brain / pathology. Female. Humans. Magnetic Resonance Imaging. Meninges / pathology. Middle Aged. Neoplasm Invasiveness. Reconstructive Surgical Procedures / methods. Scalp / pathology

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  • (PMID = 18718834.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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26. Varughese JK, Wentzel-Larsen T, Vassbotn F, Moen G, Lund-Johansen M: Analysis of vestibular schwannoma size in multiple dimensions: a comparative cohort study of different measurement techniques. Clin Otolaryngol; 2010 Apr;35(2):97-103
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  • [Title] Analysis of vestibular schwannoma size in multiple dimensions: a comparative cohort study of different measurement techniques.
  • OBJECTIVES: In this volumetric study of the vestibular schwannoma, we evaluated the accuracy and reliability of several approximation methods that are in use, and determined the minimum volume difference that needs to be measured for it to be attributable to an actual difference rather than a retest error.
  • [MeSH-major] Ear Neoplasms / pathology. Magnetic Resonance Imaging / methods. Neoplasm Invasiveness. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Gadolinium. Humans. Incidence. Isotopes. Male. Middle Aged. Neoplasm Staging. Observer Variation. Radiosurgery / instrumentation. Reproducibility of Results. Research Design

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  • (PMID = 20500578.001).
  • [ISSN] 1749-4486
  • [Journal-full-title] Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
  • [ISO-abbreviation] Clin Otolaryngol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Isotopes; AU0V1LM3JT / Gadolinium
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27. Bennett ML, Jackson CG, Kaufmann R, Warren F: Postoperative imaging of vestibular schwannomas. Otolaryngol Head Neck Surg; 2008 May;138(5):667-71
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  • [Title] Postoperative imaging of vestibular schwannomas.
  • OBJECTIVES: Assess the need for serial magnetic resonance imaging after vestibular schwannoma surgery.
  • SUBJECTS AND METHODS: Study included all patients who underwent vestibular neuromas surgery over a five-year period from 1996 to 2000 at a single tertiary referral center.
  • Analysis of tumor recurrence and correlation with enhancement types on postoperative imaging was performed.
  • RESULTS: During the five-year period, 359 cerebellopontine angle tumors were removed.
  • Two patients with nodular enhancement had tumor recurrence.
  • CONCLUSIONS: Complete vestibular schwannoma resection has a low recurrence rate.
  • [MeSH-major] Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / surgery. Postoperative Care

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  • (PMID = 18439476.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Gimsing S: Vestibular schwannoma: when to look for it? J Laryngol Otol; 2010 Mar;124(3):258-64
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  • [Title] Vestibular schwannoma: when to look for it?
  • OBJECTIVES:. (1) To compare audiometric parameters in patients with vestibular schwannoma and in those with asymmetric hearing loss from other causes; and (2) to assess proposed screening criteria by comparing published protocols.
  • METHODS: Audiometric data from 199 vestibular schwannoma patients and 225 non-tumour patients were compared.
  • RESULTS: Vestibular schwannoma and non-tumour patients with little or no hearing loss in the unaffected ear were inseparable; however, vestibular schwannoma patients with hearing loss in the unaffected ear had greater audiometric asymmetry, compared with non-tumour patients with the same pattern of hearing loss.
  • CONCLUSION: As regards vestibular schwannoma screening protocols, the best compromise between sensitivity and screening rate was offered by a criterion comprising either:.
  • [MeSH-major] Audiometry. Hearing Loss, Unilateral / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 19922702.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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29. Brackmann DE, Green JD Jr: Translabyrinthine approach for acoustic tumor removal. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):251-64, vi
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  • [Title] Translabyrinthine approach for acoustic tumor removal. 1992.
  • It is the preferred approach for removal of all tumors in patients with poor hearing and for large tumors when the likelihood of hearing preservation is slight.
  • This approach offers the advantages of minimum cerebellar retraction, identification of the facial nerve proximally and medially, and the ability to repair immediately the facial nerve if it is severed during acoustic tumor removal.
  • [MeSH-major] Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534338.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Brackmann DE; Green JD Jr
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30. Thamburaj K, Radhakrishnan VV, Thomas B, Nair S, Menon G: Intratumoral microhemorrhages on T2*-weighted gradient-echo imaging helps differentiate vestibular schwannoma from meningioma. AJNR Am J Neuroradiol; 2008 Mar;29(3):552-7
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  • [Title] Intratumoral microhemorrhages on T2*-weighted gradient-echo imaging helps differentiate vestibular schwannoma from meningioma.
  • BACKGROUND AND PURPOSE: Vestibular schwannomas (VS) may be difficult to differentiate from cerebellopontine angle (CPA) meningiomas.
  • This finding is useful to differentiate VS from CPA meningiomas.
  • T2*-weighted GRE should be used as a basic sequence to evaluate CPA tumors.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebral Hemorrhage / diagnosis. Echo-Planar Imaging / methods. Meningioma / diagnosis. Microcirculation / pathology. Neuroma, Acoustic / diagnosis

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  • (PMID = 18079187.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Darwish BS, Bird PA, Goodisson DW, Bonkowski JA, MacFarlane MR: Facial nerve function and hearing preservation after retrosigmoid excision of vestibular schwannoma: Christchurch Hospital experience with 97 patients. ANZ J Surg; 2005 Oct;75(10):893-6
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  • [Title] Facial nerve function and hearing preservation after retrosigmoid excision of vestibular schwannoma: Christchurch Hospital experience with 97 patients.
  • BACKGROUND: Between January 1988 and December 2002, 97 patients underwent surgery for excision of vestibular schwannoma via the retrosigmoid approach at Christchurch Hospital.
  • METHODS: A retrospective review was undertaken of the clinical notes with emphasis on facial nerve function and hearing preservation postoperatively.
  • RESULTS: Of patients with small and medium-sized tumours, 81% had good facial nerve function at 1 year (House-Brackmann grade 1 and grade 2), 16% had moderate function (grade 3 and grade 4) and 3% had poor function (grade 5).
  • CONCLUSIONS: Tumour size was an important predictor of the postoperative facial and cochlear nerve function.
  • [MeSH-major] Facial Nerve / physiology. Hearing / physiology. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Auditory Threshold. Female. Hearing Loss / etiology. Humans. Male. Neoplasm Recurrence, Local. Neurofibromatosis 2 / surgery. Postoperative Complications. Retrospective Studies. Time Factors. Tinnitus / etiology. Treatment Outcome. Vertigo / etiology

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  • (PMID = 16176235.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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32. Astner ST, Nieder C, Stock K, Gaa J, Grosu AL: Carcinomatous meningitis appearing as acoustic neuromas: two cases. Strahlenther Onkol; 2007 May;183(5):279-83
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  • [Title] Carcinomatous meningitis appearing as acoustic neuromas: two cases.
  • BACKGROUND: For acoustic neuromas, stereotactic radiotherapy (radiosurgery or stereotactic fractionated radiotherapy) has been established as an important alternative to microsurgery.
  • MRI scan shows a contrast-enhancing tumor within the inner auditory channel.
  • If medical history does not match with acoustic neuroma, further diagnostics are necessary to rule out infectious disease or carcinomatous meningitis.
  • CASE REPORT: Two patients with hearing loss, vertigo and the diagnosis of acoustic neuromas by MRI scan were referred for radiotherapy.
  • In both cases the symptoms progressed very rapidly, not typical of acoustic neuromas, and in both patients repeated liquor puncture finally revealed carcinomatous meningitis.
  • This is especially true for bilateral lesions suspicious for acoustic neuromas and rapid progression and persistence of clinical symptoms where carcinomatous meningitis has to be taken into account.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Meningeal Neoplasms / secondary. Neoplasms, Multiple Primary / diagnosis. Neuroma, Acoustic / diagnosis

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  • (PMID = 17497100.001).
  • [ISSN] 0179-7158
  • [Journal-full-title] Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
  • [ISO-abbreviation] Strahlenther Onkol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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33. Bonneville F, Savatovsky J, Chiras J: Imaging of cerebellopontine angle lesions: an update. Part 2: intra-axial lesions, skull base lesions that may invade the CPA region, and non-enhancing extra-axial lesions. Eur Radiol; 2007 Nov;17(11):2908-20
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  • Computed tomography (CT) and magnetic resonance (MR) imaging reliably demonstrate typical features of vestibular schwannomas or meningiomas in the vast majority of mass lesions responsible for cerebellopontine angle (CPA) syndrome.
  • Finally, brain stem or ventricular tumours can present with a significant exophytic component in the CPA that may be difficult to differentiate from an extra-axial lesion (lymphoma, hemangioblastoma, choroid plexus papilloma, ependymoma, glioma, medulloblastoma, dysembryoplastic neuroepithelial tumour).
  • [MeSH-minor] Adult. Aged. Algorithms. Diagnosis, Differential. Diffusion Magnetic Resonance Imaging / methods. Female. Gadolinium / pharmacology. Humans. Male. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Middle Aged. Neoplasm Invasiveness. Neuroma, Acoustic / diagnosis

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  • (PMID = 17569053.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
  • [Number-of-references] 75
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34. Muscat JE, Hinsvark M, Malkin M: Mobile telephones and rates of brain cancer. Neuroepidemiology; 2006;27(1):55-6
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  • [Title] Mobile telephones and rates of brain cancer.
  • The risk of most primary brain cancers including gliomas and acoustic neuromas is unrelated to the use of mobile telephones in several studies.
  • An increased risk caused by short-term mobile phone use was reported for neuroepithelial tumors, a rare histologic subgroup of brain cancers that are characterized by neuronal features.
  • [MeSH-major] Brain Neoplasms / epidemiology. Cell Phones / utilization. Ganglioglioma / epidemiology

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  • (PMID = 16825795.001).
  • [ISSN] 0251-5350
  • [Journal-full-title] Neuroepidemiology
  • [ISO-abbreviation] Neuroepidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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35. Ahlbom A, Feychting M, Green A, Kheifets L, Savitz DA, Swerdlow AJ, ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology: Epidemiologic evidence on mobile phones and tumor risk: a review. Epidemiology; 2009 Sep;20(5):639-52
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  • [Title] Epidemiologic evidence on mobile phones and tumor risk: a review.
  • This review summarizes and interprets epidemiologic evidence bearing on a possible causal relation between radiofrequency field exposure from mobile phone use and tumor risk.
  • In the last few years, epidemiologic evidence on mobile phone use and the risk of brain and other tumors of the head in adults has grown in volume, geographic diversity of study settings, and the amount of data on longer-term users.
  • Overall the studies published to date do not demonstrate an increased risk within approximately 10 years of use for any tumor of the brain or any other head tumor.
  • Despite the methodologic shortcomings and the limited data on long latency and long-term use, the available data do not suggest a causal association between mobile phone use and fast-growing tumors such as malignant glioma in adults (at least for tumors with short induction periods).
  • For slow-growing tumors such as meningioma and acoustic neuroma, as well as for glioma among long-term users, the absence of association reported thus far is less conclusive because the observation period has been too short.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Glioma / etiology. Neoplasms, Radiation-Induced / etiology. Risk Assessment
  • [MeSH-minor] Brain / radiation effects. Humans. Research Design

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  • [CommentIn] Epidemiology. 2009 Sep;20(5):653-5 [19620872.001]
  • (PMID = 19593153.001).
  • [ISSN] 1531-5487
  • [Journal-full-title] Epidemiology (Cambridge, Mass.)
  • [ISO-abbreviation] Epidemiology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 48
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36. Raptis HA, Dannenbaum E, Paquet N, Feldman AG: Vestibular system may provide equivalent motor actions regardless of the number of body segments involved in the task. J Neurophysiol; 2007 Jun;97(6):4069-78
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  • [Title] Vestibular system may provide equivalent motor actions regardless of the number of body segments involved in the task.
  • To test this hypothesis, we compared the ability of healthy subjects and patients with unilateral vestibular lesions (surgical acoustic neuroma resection 0.6 to 6.7 yr before the study) to maintain either the same hand position or the same trajectory of within arm reach movements while flexing the trunk, in the absence of vision.
  • Results suggest that vestibular influences evoked by the head motion during trunk flexion play a major role in maintaining the consistency of arm motor actions in external space despite changes in the number of body segments involved.
  • Our findings also suggest that despite long-term plasticity in the vestibular system and related neural structures, unilateral vestibular lesion may reduce the capacity of the nervous system to achieve motor equivalence.
  • [MeSH-minor] Adult. Analysis of Variance. Electromyography. Female. Functional Laterality. Humans. Male. Middle Aged. Task Performance and Analysis. Upper Extremity / innervation. Vestibular Diseases / physiopathology

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  • (PMID = 17428903.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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37. Browne JD, Fisch U: Transotic approach to the cerebellopontine angle. 1992. Neurosurg Clin N Am; 2008 Apr;19(2):265-78, vi
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  • The transotic approach to the cerebellopontine angle has been developed at the University of Zurich for the removal of acoustic tumors in an effort to increase operative exposure and enhance facial nerve preservation and reconstruction.
  • Key steps involve the total removal of all pneumatic cell tracts with middle ear and eustachian tube obliteration, followed by complete otic capsule removal for tumor exposure.
  • [MeSH-major] Cerebellar Neoplasms / history. Cerebellopontine Angle. Neuroma, Acoustic / history. Neurosurgical Procedures / history. Otologic Surgical Procedures / history

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  • (PMID = 18534339.001).
  • [ISSN] 1558-1349
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Biography; Classical Article; Historical Article; Journal Article
  • [Publication-country] United States
  • [Personal-name-as-subject] Browne JD; Fisch U
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38. Freeman SR, Ramsden RT, Saeed SR, Alzoubi FQ, Simo R, Rutherford SA, King AT: Revision surgery for residual or recurrent vestibular schwannoma. Otol Neurotol; 2007 Dec;28(8):1076-82
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  • [Title] Revision surgery for residual or recurrent vestibular schwannoma.
  • OBJECTIVE: Assess the requirement for and describe the complication rates of revision surgery for vestibular schwannoma.
  • PATIENTS: Patients undergoing surgery for vestibular schwannoma by the Manchester Neurotology Service between 1978 and 2004.
  • MAIN OUTCOME MEASURE(S): The presence of recurrent or residual tumor; necessity for further treatment; complications from revision surgery.
  • RESULTS: Primary surgery was undertaken on 1,037 tumors, with 866 total (19 recurred), 128 near-total, and 43 subtotal removals.
  • Further treatment was performed for 4 recurrent, 2 near-total, and 11 subtotal excised tumors.
  • Other complications of revision surgery included 3 patients with cerebrospinal fluid leaks, a postoperative hematoma requiring evacuation, 2 cerebrovascular accidents, and 2 patients with new cranial nerve deficits.
  • CONCLUSION: Most residual tumors after primary surgery are successfully managed with watch and rescan.
  • Tumor fragment size is the greatest determinant of revision treatment.
  • After revision surgery, tumor regrowth is much less predictable.
  • Revision surgery is usually considerably more difficult than primary surgery, with a higher complication rate, particularly with regard to the facial nerve.
  • Changing the approach for revision surgery may confer an advantage to facial nerve function.
  • [MeSH-major] Ear Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures
  • [MeSH-minor] Adolescent. Adult. Aged. Databases, Factual. Facial Nerve / pathology. Facial Nerve / physiopathology. Female. Humans. Male. Middle Aged. Postoperative Complications / epidemiology. Reoperation / adverse effects. Sex Ratio

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  • (PMID = 18043433.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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39. Smouha EE, Yoo M, Mohr K, Davis RP: Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm. Laryngoscope; 2005 Mar;115(3):450-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm.
  • OBJECTIVES/HYPOTHESES: Conservative management is a viable treatment alternative for acoustic neuroma.
  • METHODS: Published studies on conservative management of acoustic neuroma were found using a key word search through PubMed in addition to the bibliographies of these selected studies.
  • A spreadsheet was made to tabulate the selection criteria for conservative management, duration and frequency of follow-up, patient demographics, initial tumor size and rate of growth, change in hearing status, and the need for definitive treatment.
  • The average initial tumor size was 11.8 mm (n = 900); 43% of 1,244 acoustic neuromas showed growth, whereas 57% showed either no growth or tumor regression.
  • CONCLUSIONS: Our meta-analysis supports the role of conservative management of acoustic neuromas in properly selected patients on the basis of a slow overall rate of growth and a substantial incidence of no growth.
  • An algorithm for acoustic neuroma management is proposed based on initial tumor size, patient age, and hearing status.
  • [MeSH-major] Algorithms. Neuroma, Acoustic / therapy

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  • [CommentIn] Laryngoscope. 2005 Sep;115(9):1704; author reply 1704 [16148723.001]
  • (PMID = 15744156.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] United States
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40. Shuto T, Inomori S, Matsunaga S, Fujino H: Microsurgery for vestibular schwannoma after gamma knife radiosurgery. Acta Neurochir (Wien); 2008 Mar;150(3):229-34; discussion 234
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  • [Title] Microsurgery for vestibular schwannoma after gamma knife radiosurgery.
  • BACKGROUND: We evaluated the clinical characteristics of microsurgery for vestibular schwannoma (VS) after failed gamma knife radiosurgery (GKS).
  • Adhesion to the brain stem was severe in 7 patients.
  • Identification of the facial nerve was easy in 5 operations and difficult in 7.
  • Dissection of the tumour from the facial nerve was difficult in most interventions because of severe adhesions or colour change.
  • Severe adhesions between the trigeminal nerve and the tumour was observed in 2 patients.
  • The function of the facial nerve deteriorated in 3 patients, was unchanged in 7, and improved in 2.
  • Dissection of the tumour from the facial nerve or brain stem is likely to be difficult.
  • We recommend subtotal resection without dissection of the facial nerve and tumour, because growth of the residual tumour was rare in our series.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery. Radiosurgery / methods. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Dissection / methods. Dissection / standards. Ear, Inner / anatomy & histology. Ear, Inner / pathology. Ear, Inner / surgery. Facial Nerve / pathology. Facial Nerve / physiopathology. Facial Nerve / surgery. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / prevention & control. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Neurosurgical Procedures / statistics & numerical data. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Retrospective Studies. Treatment Failure. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / physiopathology. Trigeminal Nerve / surgery

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  • (PMID = 18253695.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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41. Yonekawa Y: [On the occasion of my retirement as head of the Neurochirurgische Universitätsklinik Zürich--changing aspects of treatment modality in modern neurosurgery and of neuroscience research. Presentation of our experience and historical backgrounds]. Brain Nerve; 2008 May;60(5):538-46
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  • Traditionally, carotid endarterectomy belonged to vascular surgeons in our hospital, but the tendency of conversion from conventional carotid endarterectomy to endovascular PTA and/or stenting seemed to be marked, while microvascular revascularization procedure represented by extracranial intracranial EC-IC bypass remained constant (around 20/year) in various occasion (277 times on 203 cases: atherosclerosis 93, Moyamoya angiopathy (MMA) 47, aneurysm 57 and skull base tumour 6, during the last 13 years], in spite of negative results of EC-IC bypass international cooperative study for stroke prevention in 1985.
  • Acoustic neurinoma (just less than 20/year) is one of benign brain tumours whose treatment has changed remarkably.
  • Thanks to development of intaroperative neurophysiological monitoring and of surgical technique, preservation of facial nerve function has improved from 60% to more than 85% in spite of the increase of size.
  • [MeSH-minor] Brain Neoplasms / surgery. Cerebral Revascularization / methods. Cerebral Revascularization / trends. Humans. Hydrocephalus / surgery. Intracranial Aneurysm / surgery. Intracranial Arteriovenous Malformations / surgery. Switzerland. Universities

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  • (PMID = 18516976.001).
  • [ISSN] 1881-6096
  • [Journal-full-title] Brain and nerve = Shinkei kenkyū no shinpo
  • [ISO-abbreviation] Brain Nerve
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 33
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42. Marouf R, Noudel R, Roche PH: Facial nerve outcome after microsurgical resection of vestibular schwannoma. Prog Neurol Surg; 2008;21:103-7
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  • [Title] Facial nerve outcome after microsurgical resection of vestibular schwannoma.
  • The risk of facial nerve palsy after microsurgical removal of vestibular schwannoma cannot be totally eradicated.
  • Taken together, the data from our personal experience and analysis of the literature indicate that the major predictor of postoperative facial deficit is tumor size.
  • When confronted with large tumors, we personally changed our surgical goals and considered that facial nerve conservation and tumor control are interconnected priorities instead of radical removal.
  • [MeSH-major] Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Facial Paralysis / epidemiology. Facial Paralysis / prevention & control. Microsurgery / adverse effects. Neuroma, Acoustic / surgery

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  • (PMID = 18810207.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 23
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43. Fisher LM, Doherty JK, Lev MH, Slattery WH: Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium. Otol Neurotol; 2009 Sep;30(6):835-41
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  • [Title] Concordance of bilateral vestibular schwannoma growth and hearing changes in neurofibromatosis 2: neurofibromatosis 2 natural history consortium.
  • OBJECTIVE: To examine the relationship between the amount of change in size and associated hearing in bilateral vestibular schwannomas (VSs) in persons with neurofibromatosis 2 (NF2).
  • OUTCOME MEASURES: Greatest diameter change in tumor size for each of the 2 tumors from first to second evaluation was determined.
  • The amount of change in the bigger tumors was not associated with the amount of change in the smaller tumors within each patient.
  • Vestibular schwannoma size changes were not associated with the corresponding hearing changes (Kendall's tau, p = not significant [n.s.]).
  • Clinically, tumor change or hearing deterioration on one VS cannot be used to predict changes in the other vs. This suggests that, although NF2 is a Mendelian disease, the germline genotype-phenotype relationship may resemble that of complex disorders.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Hearing Loss / etiology. Neurofibromatosis 2 / complications. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry, Pure-Tone. Child. Child, Preschool. Disease Progression. Female. Genes, Neurofibromatosis 2 / physiology. Genotype. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurofibromin 2 / blood. Neurofibromin 2 / genetics. Phenotype. Prospective Studies. Retrospective Studies. Young Adult

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  • (PMID = 19704365.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2
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44. Jeblaoui Y, Neji B, Haddad S, Mnif D, Hchicha S: [Difficulties of the management of head and neck neurofibromatosis]. Ann Chir Plast Esthet; 2007 Feb;52(1):43-50
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  • [Transliterated title] Difficultés de la prise en charge des atteintes de l'extrémité céphalique dans les neurofibromatoses.
  • Neurofibromatosis type 1 (NF1) or Von Recklinghausen's neurofibromatosis is an autosomal dominantly inherited disease, whose prevalence is 1/4500.
  • Neurofibromatosis type 2 (NF2) is also an autosomal dominantly inherited disease, but is ten times less frequent than the NF1 and is characterized by bilateral vestibular schwannomas (former acoustic neurinomas).
  • Surgical resection of the tumor was carried out among 8 patients with bone reconstruction of the orbit on 3 patients and cutaneous expansion on one other.
  • However, all our patients were satisfied with the result and we noted recurrence in a patient presenting a retro-auricular tumor, which filled the external auditory canal requiring a further surgery.
  • Cancer risks and the disease's completely unpredictable evolution urge a regular and multidisciplinary patient follow-up.

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  • (PMID = 17137698.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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45. Herwadker A, Vokurka EA, Evans DG, Ramsden RT, Jackson A: Size and growth rate of sporadic vestibular schwannoma: predictive value of information available at presentation. Otol Neurotol; 2005 Jan;26(1):86-92
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  • [Title] Size and growth rate of sporadic vestibular schwannoma: predictive value of information available at presentation.
  • BACKGROUND: The current study examines the hypothesis that tumor growth rate in sporadic vestibular schwannoma could be in part predicted by data available at diagnosis, such as tumor volume, patient age, laterality, and sex.
  • METHODS: Tumor volumes and growth rates were calculated from serial magnetic resonance imaging data in a cohort of 50 patients (26 men and 24 women; mean age at presentation, 64.1 +/- 12.8 yr).
  • Tumor volumes were measured using an algorithm that corrects for partial volume averaging errors and provides accurate estimates of tumor volume with known errors.
  • RESULTS: Examination of presentation data showed no relationship between tumor size at diagnosis and patient age, sex, or tumor laterality.
  • Two measurements of tumor growth--absolute growth per annum and tumor volume doubling time--were studied, and neither showed any relationship with tumor size at presentation, patient age, tumor laterality, or sex.
  • This indicates that the clinical features available at presentation and diagnosis have no power to predict the expected behavior of sporadic vestibular schwannoma.
  • [MeSH-major] Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Neuroma, Acoustic / diagnosis. Tumor Burden / physiology
  • [MeSH-minor] Adult. Age Factors. Aged. Aged, 80 and over. Algorithms. Cohort Studies. Disease Progression. Dominance, Cerebral / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 15699725.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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46. Tufarelli D, Meli A, Alesii A, De Angelis E, Badaracco C, Falcioni M, Sanna M: Quality of life after acoustic neuroma surgery. Otol Neurotol; 2006 Apr;27(3):403-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality of life after acoustic neuroma surgery.
  • OBJECTIVE: The aim of this study is to assess patients' quality of life after acoustic neuroma surgery, and if some patients' characteristics, parameters of tumor and surgical parameters affect patients' quality of life.
  • PATIENTS: A group of 386 patients who underwent acoustic neuroma surgery.
  • INTERVENTION: Patients included were derived from a population of 459 subjects operated for acoustic neuroma by the Otologic Group of Piacenza.
  • Our data indicate that an early surgical approach for intrameatal tumor is better than waiting for an increase in the tumor size.
  • A "wait-and-scan" strategy for extrameatal neuromas which do not affect the brainstem is preferable, since these patients have a worsening of their quality of life after surgery independently of the tumor size.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / psychology. Quality of Life

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  • (PMID = 16639281.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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47. Behari S, Tyagi I, Banerji D, Kumar V, Jaiswal AK, Phadke RV, Jain VK: Postauricular, transpetrous, presigmoid approach for extensive skull base tumors in the petroclival region: the successes and the travails. Acta Neurochir (Wien); 2010 Oct;152(10):1633-45
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  • [Title] Postauricular, transpetrous, presigmoid approach for extensive skull base tumors in the petroclival region: the successes and the travails.
  • METHODS: The lesions (n = 14) included petroclival meningiomas [(n = 5), including three recurrent lesions], dumbbell lower cranial nerve schwannomas (n = 2), giant acoustic schwannomas (n = 2), recurrent giant trigeminal nerve schwannoma (n = 1), glomus jugulare (n = 3), and recurrent petrous aneurysmal bone cyst (n = 1).
  • Small tumor remnants were left attached to the brainstem (n = 3, petroclival meningioma), carotid canal and cavernous sinus (n = 1, glomus jugulare), and sigmoid sinus-jugular bulb (n = 1, recurrent trigeminal schwannoma).
  • Two patients with recurrent giant petroclival meningiomas died: one with lower cranial nerve paresis due to aspiration pneumonitis and the other with cerebrospinal fluid otorrhoea and secondary meningitis.
  • CONCLUSIONS: The approach facilitates direct tumor decompression and its retraction away from the brainstem without initially encountering the intracisternal cranial nerves and neuraxis.
  • It provides multiple corridors for excising extensive posterior fossa tumors.
  • [MeSH-minor] Glomus Jugulare Tumor / diagnosis. Glomus Jugulare Tumor / pathology. Glomus Jugulare Tumor / surgery. Humans. Meningeal Neoplasms / diagnosis. Meningeal Neoplasms / pathology. Meningeal Neoplasms / surgery. Meningioma / diagnosis. Meningioma / pathology. Meningioma / surgery. Neurilemmoma / diagnosis. Neurilemmoma / pathology. Neurilemmoma / surgery. Retrospective Studies

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  • (PMID = 20556624.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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48. Smith MC, Ryken TC, Buatti JM: Radiotoxicity after conformal radiation therapy for benign intracranial tumors. Neurosurg Clin N Am; 2006 Apr;17(2):169-80, vii
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  • [Title] Radiotoxicity after conformal radiation therapy for benign intracranial tumors.
  • Acoustic schwannomas, skull base meningiomas, and pituitary adenomas are benign intracranial tumors frequently managed with radiotherapy.
  • Control rates after treatment for each of these tumors are generally high, and toxicity from treatment is relatively low.
  • Side effect profiles depend on the tumor location, the volume treated, the dose delivered, and the presence of nearby critical structures.
  • This article reviews radiotoxicity after conformal radiation therapy for acoustic schwannomas, skull base meningiomas, and pituitary adenomas.
  • [MeSH-major] Brain Neoplasms / radiotherapy. Neuroma, Acoustic / radiotherapy. Radiotherapy, Conformal / adverse effects

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  • (PMID = 16793508.001).
  • [ISSN] 1042-3680
  • [Journal-full-title] Neurosurgery clinics of North America
  • [ISO-abbreviation] Neurosurg. Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 27
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49. Plotkin SR, Halpin C, McKenna MJ, Loeffler JS, Batchelor TT, Barker FG 2nd: Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients. Otol Neurotol; 2010 Sep;31(7):1135-43
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  • [Title] Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients.
  • We sought to determine the activity of erlotinib for progressive vestibular schwannoma (VS) associated with neurofibromatosis 2 (NF2).
  • MAIN OUTCOME MEASURES: A radiographic response was defined as >or= 20% decrease in tumor volume compared with baseline.
  • Among 10 evaluable patients, the median time-to-tumor progression was 9.2 months.
  • Three patients with stable disease experienced maximum tumor shrinkage of 4%, 13%, and 14%.
  • The median time-to-progressive hearing loss was 9.2 months and to either tumor growth or progressive hearing loss was 7.1 months.
  • CONCLUSION: Erlotinib treatment was not associated with radiographic or hearing responses in NF2 patients with progressive vs. Because a subset of patients experienced prolonged stable disease, time-to-progression may be more appropriate than radiographic or hearing response for anti-EGFR agents in NF2-associated vs.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Neurofibromatosis 2 / drug therapy. Neuroma, Acoustic / drug therapy. Quinazolines / therapeutic use
  • [MeSH-minor] Adolescent. Adult. Audiometry, Pure-Tone. Disease Progression. Erlotinib Hydrochloride. Female. Hearing Loss, Sensorineural / complications. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Speech Perception / physiology. Treatment Outcome. Young Adult

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  • (PMID = 20736812.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / P01 NS024279; United States / NINDS NIH HHS / NS / P01 NS024279-23; United States / NIDCD NIH HHS / DC / R01 DC009837
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
  • [Other-IDs] NLM/ NIHMS570073; NLM/ PMC4030413
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50. Coelho DH, Roland JT Jr, Rush SA, Narayana A, St Clair E, Chung W, Golfinos JG: Small vestibular schwannomas with no hearing: comparison of functional outcomes in stereotactic radiosurgery and microsurgery. Laryngoscope; 2008 Nov;118(11):1909-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small vestibular schwannomas with no hearing: comparison of functional outcomes in stereotactic radiosurgery and microsurgery.
  • OBJECTIVES: To date, numerous studies have compared functional outcomes between stereotactic radiosurgery (SRS) and microsurgery (MS) in the treatment of vestibular schwannomas (VS).
  • However, most of them involve tumors of difference sizes, radiation dosages, and surgical approaches.
  • By studying only patients with small tumors and no hearing, we sought to minimize confounding variables.
  • All MS patients underwent the translabyrinthine approach to their tumors.
  • Outcomes measurements included tumor control, facial nerve function, tinnitus, trigeminal function, and imbalance.
  • RESULTS: Patients undergoing SRS had comparable rates of tumor control, facial nerve function, tinnitus, and trigeminal function to MS patients.
  • CONCLUSIONS: In our study population, patients with small tumors and no serviceable hearing, these data suggest that MS results in comparable minimal morbidity with SRS, though posttreatment dysequilibrium is significantly decreased.
  • [MeSH-major] Facial Nerve / physiopathology. Hearing / physiology. Microsurgery / methods. Neuroma, Acoustic / physiopathology. Postural Balance / physiology. Radiosurgery / methods. Trigeminal Nerve / physiopathology

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  • (PMID = 18849856.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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51. Aihara N, Murakami S, Watanabe N, Takahashi M, Inagaki A, Tanikawa M, Yamada K: Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery. Skull Base; 2009 Sep;19(5):325-32
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  • [Title] Cochlear nerve action potential monitoring with the microdissector in vestibular schwannoma surgery.
  • We developed a cochlear nerve action potential (CNAP) monitoring technique using a microdissector and compared the results of CNAP and auditory brainstem response (ABR) monitoring.
  • Thirty-six patients underwent vestibular schwannoma resection via the retrosigmoid approach to preserve hearing.
  • We used the microdissector as an intracranial electrode for CNAP monitoring.
  • At the completion of the tumor resection, the triphasic waveform was observed in 11 patients and the biphasic waveform was observed in 11 patients.

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  • (PMID = 20190942.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765700
  • [Keywords] NOTNLM ; auditory brainstem response / cochlear nerve action potential / microdissector / vestibular schwannoma
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52. Peñarrocha-Diago M, Mora-Escribano E, Bagán JV, Peñarrocha-Diago M: Neoplastic trigeminal neuropathy: presentation of 7 cases. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E106-11
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  • We present 7 cases of trigeminal neuropathy secondary to tumors: in four cases there were antecedents of systemic neoplastic disease, while in the remaining three cases neuropathy was the first manifestation of the tumor.
  • The lesion was located in the mandible in three cases, in the region of the skull base in one patient, and in the brainstem and brain in one case each.
  • Recovery was only recorded in one patient in whom the symptoms were seen to disappear after acoustic nerve neurinoma resection.
  • The lesions underlying neoplastic trigeminal neuropathy can be located at any point along the trajectory of the trigeminal nerve, and their prognosis is very poor.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / diagnosis. Trigeminal Nerve Diseases / diagnosis. Trigeminal Nerve Diseases / etiology

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  • (PMID = 16505784.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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53. Neff BA, Welling DB, Akhmametyeva E, Chang LS: The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level. Otol Neurotol; 2006 Feb;27(2):197-208
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The molecular biology of vestibular schwannomas: dissecting the pathogenic process at the molecular level.
  • OBJECTIVE: The goal of this article was to review concisely what is currently known about the tumorigenesis of vestibular schwannomas.
  • BACKGROUND: Recent advances in molecular biology have led to a better understanding of the cause of vestibular schwannomas.
  • Mutations in the neurofibromatosis type 2 tumor suppressor gene (NF2) have been identified in these tumors.
  • In addition, the interactions of merlin, the protein product of the NF2 gene, and other cellular proteins are beginning to give us a better idea of NF2 function and the pathogenesis of vestibular schwannomas.
  • RESULTS: The clinical characteristics of vestibular schwannomas and neurofibromatosis type 2 syndromes are reviewed and related to alterations in the NF2 gene.
  • Studies demonstrating our current understanding of tumor developmental pathways are highlighted.
  • In addition, methods of clinical and genetic screening for neurofibromatosis type 2 disease are outlined.
  • CONCLUSION: Great strides have been made to identify why vestibular schwannomas develop at the molecular level.
  • Continued research is needed to find targeted therapies with which to treat these tumors.
  • [MeSH-major] Chromosomes, Human, Pair 22. Genes, Neurofibromatosis 2. Mutation. Neurofibromin 2 / genetics. Neuroma, Acoustic / genetics
  • [MeSH-minor] Alternative Splicing. Animals. Disease Models, Animal. Genetic Testing. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Mice. Promoter Regions, Genetic. RNA, Messenger / genetics. Signal Transduction / genetics

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  • (PMID = 16436990.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Neurofibromin 2; 0 / RNA, Messenger
  • [Number-of-references] 114
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54. Boisson-Bertrand D, Laxenaire MC, Mertes PM: Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane. Anaesth Intensive Care; 2006 Jun;34(3):338-42
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  • [Title] Recovery after prolonged anaesthesia for acoustic neuroma surgery: desflurane versus isoflurane.
  • In this study, 33 patients were randomly assigned to receive desflurane (D) or isoflurane (I) for acoustic neuroma surgery.
  • The results indicate that desflurane is associated with similar operating conditions and faster postoperative recovery following acoustic neuroma surgery.
  • [MeSH-major] Anesthesia Recovery Period. Anesthesia, Inhalation. Anesthetics, Inhalation. Isoflurane / analogs & derivatives. Neuroma, Acoustic / surgery

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  • (PMID = 16802487.001).
  • [ISSN] 0310-057X
  • [Journal-full-title] Anaesthesia and intensive care
  • [ISO-abbreviation] Anaesth Intensive Care
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Anesthetics, Inhalation; CRS35BZ94Q / desflurane; CYS9AKD70P / Isoflurane
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55. Dublin A: Acoustic neuroma or vestibular schwannoma? Skull Base; 2009 Sep;19(5):375
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  • [Title] Acoustic neuroma or vestibular schwannoma?

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  • (PMID = 20190950.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2765706
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56. Dumas G, De Waele C, Hamann KF, Cohen B, Negrevergne M, Ulmer E, Schmerber S: [Skull vibration induced nystagmus test]. Ann Otolaryngol Chir Cervicofac; 2007 Sep;124(4):173-83
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  • [Transliterated title] Le test vibratoire osseux vestibulaire.
  • Total unilateral peripheral lesions (tUVL: operated vestibular shwannomas, vestibular neurectomies) and partial unilateral peripheral lesions (pUVL: preoperative neuromas, Meniere's disease, vestibular neuritis, chemical labyrinthectomies) were studied.
  • SVINT is positive in 6 to 10% of the normal population, 31% of brain stem lesions and negative in total bilateral vestibular peripheral lesions.
  • CONCLUSIONS: SVINT is an effective, rapid and non invasive test used to detect vestibular asymmetry between 20 to 150 Hz stimulation.
  • SVINT is useful in the diagnosis of labyrinthine hydrops or detection of acoustic neuromas.
  • This test does not precisely point out the level of the lesion on the vestibular pathway.
  • [MeSH-minor] Adult. Aged. Caloric Tests. Edema / diagnosis. Edema / epidemiology. False Positive Reactions. Female. Humans. Male. Mastoid. Meniere Disease / diagnosis. Meniere Disease / epidemiology. Middle Aged. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / epidemiology. Prevalence. Sensitivity and Specificity. Severity of Illness Index. Skull / physiology. Vestibular Diseases / diagnosis. Vestibular Diseases / epidemiology. Vestibular Neuronitis / diagnosis. Vestibular Neuronitis / epidemiology

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  • (PMID = 17678612.001).
  • [ISSN] 0003-438X
  • [Journal-full-title] Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris
  • [ISO-abbreviation] Ann Otolaryngol Chir Cervicofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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57. Cheng S, Naidoo Y, da Cruz M, Dexter M: Quality of life in postoperative vestibular schwannoma patients. Laryngoscope; 2009 Nov;119(11):2252-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Quality of life in postoperative vestibular schwannoma patients.
  • OBJECTIVES/HYPOTHESIS: To quantify the postoperative quality of life (QOL) in patients following vestibular schwannoma surgery in a new multidisciplinary skull base unit.
  • METHODS: The Australian Short Form 36 (SF-36) quality of life health questionnaire was administered to 121 consecutive patients surgically treated for vestibular schwannoma between 1999 and 2007 at Westmead Hospital, New South Wales, Australia.
  • The postoperative QOL in vestibular schwannoma patients was significantly less than the appropriate matched healthy Australian population in one health domain of role physical limitation (P < .05).
  • Analysis of preoperative patient factors (age, gender) and surgical factors such as tumor size (cutoff points of 15 mm or 25 mm) together with, surgical approach (translabyrinthine and retrosigmoid) showed no significant difference in QOL outcomes for each of these variables (P < .05).
  • CONCLUSIONS: Results indicate that patients following vestibular schwannoma surgery reported near equivalent QOL as the healthy population.
  • Advances in surgical techniques and experiences have minimized morbidities associated with vestibular schwannoma surgery.
  • Significant physical role limitation encountered postoperatively may relate to facial nerve dysfunction, vestibular dysfunction, tinnitus or hearing loss that may persist after surgery.
  • A measured approach should still be considered for patients with small, slow growing tumors with minimal symptoms.
  • [MeSH-major] Neuroma, Acoustic / surgery. Quality of Life

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  • (PMID = 19753619.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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58. Javadpour M: Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation? Br J Neurosurg; 2009 Jun;23(3):232-3
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  • [Title] Management of vestibular schwannomas in children: a role for adult surgeons in the paediatric world? and the merits of centralisation?
  • [MeSH-major] Facial Nerve / surgery. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery

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  • [CommentOn] Br J Neurosurg. 2009 Jun;23(3):226-31 [19533454.001]
  • (PMID = 19533455.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] England
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59. Scarlett A, Bird P, Macfarlane M: Conductive hearing loss after removal of acoustic neuroma. Otol Neurotol; 2008 Jun;29(4):553-6
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  • [Title] Conductive hearing loss after removal of acoustic neuroma.
  • OBJECTIVE: To report 4 patients who have developed a conductive and/or mixed hearing loss due to dehiscence of the inner ear after retrosigmoid approach for removal of acoustic neuroma.
  • PATIENTS: Four patients who presented with conductive and/or mixed hearing loss after retrosigmoid approach for removal of acoustic neuroma.
  • CONCLUSION: The occurrence of conductive hearing loss after the surgical removal of an acoustic neuroma has not previously been documented.
  • Computed tomographic scan of the temporal bones showing inner ear dehiscence may explain this finding.
  • [MeSH-major] Cranial Nerve Neoplasms / complications. Cranial Nerve Neoplasms / surgery. Hearing Loss, Conductive / etiology. Hearing Loss, Conductive / physiopathology. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Postoperative Complications / physiopathology. Vestibulocochlear Nerve Diseases / complications. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Acoustic Impedance Tests. Adult. Aged. Audiometry. Female. Hearing Aids. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Otologic Surgical Procedures. Otoscopy. Petrous Bone / pathology. Speech Perception. Tomography, X-Ray Computed


60. Browne S, Distel E, Morton RP, Petrie KJ: Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma. J Otolaryngol Head Neck Surg; 2008 Jun;37(3):417-22
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  • [Title] Patients' quality of life, reported difficulties, and benefits following surgery for acoustic neuroma.
  • OBJECTIVES: We compared the quality of life of patients with acoustic neuroma (AN) with general population controls and other chronic illness patients.
  • METHODS: A research questionnaire was sent to all 119 members of the Acoustic Neuroma Association of New Zealand.
  • However, most AN patients do report finding some benefit from their illness experience.
  • [MeSH-major] Hearing / physiology. Neuroma, Acoustic / psychology. Otologic Surgical Procedures / methods. Quality of Life

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  • (PMID = 19128648.001).
  • [ISSN] 1916-0216
  • [Journal-full-title] Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
  • [ISO-abbreviation] J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Canada
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61. Lahkola A, Tokola K, Auvinen A: Meta-analysis of mobile phone use and intracranial tumors. Scand J Work Environ Health; 2006 Jun;32(3):171-7
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  • [Title] Meta-analysis of mobile phone use and intracranial tumors.
  • OBJECTIVES: A summary of epidemiologic evidence regarding the effect of mobile phone use on intracranial tumor risk was obtained by means of a meta-analysis.
  • METHODS: Reports of published studies on mobile phone use and intracranial tumors were sought.
  • A pooled estimate was calculated for all intracranial tumors combined and also separately for different histological tumor types.
  • Separate analyses were conducted also based on the tumor location and type of mobile telephone network (NMT or GSM).
  • RESULTS: Twelve studies with 2780 cases gave a pooled odds ratio (OR) of 0.98 [95% confidence interval (95% CI) 0.83-1.16] for all intracranial tumors related to mobile phone use.
  • For gliomas, the pooled OR was 0.96 (95% CI 0.78-1.18), for meningiomas it was 0.87 (95% CI 0.72-1.05), and for acoustic neuromas it was 1.07 (95% CI 0.89-1.30).
  • Little indication was found for increased risks of analogue or digital phone use or temporal or occipital tumors.
  • CONCLUSIONS: The totality of evidence does not indicate a substantially increased risk of intracranial tumors from mobile phone use for a period of at least 5 years.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones

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  • [CommentIn] Scand J Work Environ Health. 2006 Jun;32(3):169-70 [16804617.001]
  • (PMID = 16804618.001).
  • [ISSN] 0355-3140
  • [Journal-full-title] Scandinavian journal of work, environment & health
  • [ISO-abbreviation] Scand J Work Environ Health
  • [Language] eng
  • [Publication-type] Journal Article; Meta-Analysis
  • [Publication-country] Finland
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62. Morimoto Y, Sakabe T: [Auditory evoked potentials]. Masui; 2006 Mar;55(3):314-21
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  • Auditory evoked potentials (AEPs) are an electrical manifestation of the brain response to an auditory stimulus.
  • These waves are called the brain stem auditory evoked potentials (BAEPs) or the auditory brain stem response (ABR).
  • The BAEPs are useful during the microvascular decompression of the fifth or seventh cranial nerve, resection of acoustic neuroma and posterior fossa operations.
  • [MeSH-major] Evoked Potentials, Auditory. Evoked Potentials, Auditory, Brain Stem / physiology. Monitoring, Intraoperative / methods
  • [MeSH-minor] Anesthesia. Anesthetics / pharmacology. Auditory Pathways / physiology. Body Temperature. Brain Diseases / surgery. Humans. Reaction Time

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  • (PMID = 16541780.001).
  • [ISSN] 0021-4892
  • [Journal-full-title] Masui. The Japanese journal of anesthesiology
  • [ISO-abbreviation] Masui
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anesthetics
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63. Sandooram D, Hornigold R, Grunfeld B, Thomas N, Kitchen ND, Gleeson M: The Effect of Observation versus Microsurgical Excision on Quality of Life in Unilateral Vestibular Schwannoma: A Prospective Study. Skull Base; 2010 Jan;20(1):47-54
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  • [Title] The Effect of Observation versus Microsurgical Excision on Quality of Life in Unilateral Vestibular Schwannoma: A Prospective Study.
  • With the emergence of three effective management options for vestibular schwannoma and the drastic reduction in mortality rate, the last two decades have seen increasing attention being paid to health-related quality of life.
  • We prospectively assessed quality of life of vestibular schwannoma patients before and after conservative or microsurgical management.
  • The improved quality of life of patients 6 months after microsurgery (relative to preoperatively, and in comparison with an age- and sex- matched population) is a new finding that has not been previously documented in the literature.

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  • (PMID = 20592858.001).
  • [ISSN] 1532-0065
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2853062
  • [Keywords] NOTNLM ; Glasgow Benefit Inventory / SF-36 / Vestibular schwannoma / acoustic neuroma / quality of life
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64. Coez A, Zilbovicius M, Ferrary E, Bouccara D, Mosnier I, Ambert-Dahan E, Kalamarides M, Bizaguet E, Syrota A, Samson Y, Sterkers O: Processing of voices in deafness rehabilitation by auditory brainstem implant. Neuroimage; 2009 Oct 1;47(4):1792-6
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  • Profound acquired deafness by post-meningitis ossified cochlea and by bilateral vestibular schwannoma in neurofibromatosis type 2 patients are two indications for auditory brainstem implantation (ABI).
  • ABI allowed the transmission of sound stimuli to temporal brain regions but lacked transmitting the specific cues of the human voice to the TVA.
  • Moreover, among groups, during silent condition, brain visual regions showed higher rCBF in ABI group, although temporal brain regions had higher rCBF in the controls group.
  • [MeSH-major] Auditory Brain Stem Implantation / instrumentation. Auditory Cortex / physiology. Auditory Perception. Brain Mapping / methods. Deafness / physiopathology. Deafness / rehabilitation. Evoked Potentials, Auditory


65. Gerganov VM, Giordano M, Herold C, Samii A, Samii M: An electrophysiological study on the safety of the endoscope-assisted microsurgical removal of vestibular schwannomas. Eur J Surg Oncol; 2010 Apr;36(4):422-7
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  • [Title] An electrophysiological study on the safety of the endoscope-assisted microsurgical removal of vestibular schwannomas.
  • METHODS: We evaluated the risk of thermal or mechanical iatrogenic nerve injury related to endoscope application during microsurgical removal of vestibular schwannomas (VS) in a prospective group of 30 patients (Group A).
  • [MeSH-major] Endoscopy / methods. Microsurgery / methods. Neuroma, Acoustic / surgery

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  • [Copyright] Copyright (c) 2009 Elsevier Ltd. All rights reserved.
  • (PMID = 19942394.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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66. Otto M, von Mühlendahl KE: Electromagnetic fields (EMF): do they play a role in children's environmental health (CEH)? Int J Hyg Environ Health; 2007 Oct;210(5):635-44
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  • Final results of the INTERPHONE study on the risk of brain tumours, acoustic neurinoma and parotid gland tumours associated with the use of mobile phones will be soon available.
  • [MeSH-minor] Cell Phones. Child. Humans. Leukemia, Radiation-Induced / etiology. Microwaves


67. Roche PH, Bouvier C, Chinot O, Figarella-Branger D: Genesis and biology of vestibular schwannomas. Prog Neurol Surg; 2008;21:24-31
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  • [Title] Genesis and biology of vestibular schwannomas.
  • This review chapter is a synthesis of the recent literature about pathogenesis of schwannomas with emphasis on vestibular schwannomas (VSs).
  • The cornerstone of cellular transformation and proliferation of Schwann cells toward schwannomas has been attributed to the nonexpression of normal schwannomin/merlin (S/M) by these cells.
  • The understanding of this mechanism has been gained from molecular genetic studies of neurofibromatosis type 2 (NF2) patients, in whom mutations of a tumor suppressor gene (NF2 gene) was clearly identified.
  • Lack of normal S/M protein in the schwannoma cell is due to gene mutation in 50% of sporadic VSs.
  • The exact interactions of S/M with extracellular matrix, membranous glycoprotein and cytoskeleton are not fully understood.
  • However, it is recognized that these interactions activate several pathways that might regulate cell-cycle process, apoptosis and intercellular interaction.
  • Apart from the involvement of the S/M pathway, the authors review the potential role of other genetic abnormalities and growing factors that are supposed to be involved in the pathogenesis of vs. Understanding the pathways of action and regulation of S/M may provide the basics for identifying potential therapeutic targets, which is of paramount importance for a better management of NF2 patients.
  • [MeSH-major] Genes, Neurofibromatosis 2 / physiology. Neurofibromin 2 / physiology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology

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  • (PMID = 18810196.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Neurofibromin 2
  • [Number-of-references] 43
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68. Hours M, Bernard M, Arslan M, Montestrucq L, Richardson L, Deltour I, Cardis E: Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France. Occup Environ Med; 2009 Jul;66(7):480-6
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  • [Title] Can loud noise cause acoustic neuroma? Analysis of the INTERPHONE study in France.
  • OBJECTIVES: To investigate possible associations between risk of acoustic neuroma and exposure to loud noise in leisure and occupational settings.
  • The cases were the 108 subjects diagnosed with acoustic neuroma between 1 June 2000 and 31 August 2003.
  • RESULTS: Acoustic neuroma was found to be associated with loud noise exposure (odds ratio (OR) = 2.55; 95% CI 1.35 to 4.82), both in leisure settings, particularly when listening to loud music (OR = 3.88; 95% CI 1.48 to 10.17) and at work (OR = 2.26; 95% CI 1.08 to 4.72).
  • CONCLUSION: The present results agree with other recent reports implicating loud noise in the risk of acoustic neuroma.
  • [MeSH-major] Environmental Exposure / adverse effects. Neuroma, Acoustic / etiology. Noise / adverse effects


69. Goodwin L: Acoustic neuroma and radiosurgery. J Insur Med; 2007;39(1):44-6
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  • [Title] Acoustic neuroma and radiosurgery.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / methods. Treatment Outcome

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  • (PMID = 17500357.001).
  • [ISSN] 0743-6661
  • [Journal-full-title] Journal of insurance medicine (New York, N.Y.)
  • [ISO-abbreviation] J Insur Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Plaut J, Galloway M, Childerhouse A, Bradford R: Schwannoma with monoclonal plasma cell infiltration. J Neurosurg; 2009 Sep;111(3):509-11
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  • [Title] Schwannoma with monoclonal plasma cell infiltration.
  • The authors report a very rare case of a vestibular schwannoma with an infiltrate of monoclonal plasma cells.
  • A 45-year-old woman underwent routine excision of a presumed vestibular schwannoma.
  • Histological analysis revealed the presence of a distinct lambda light chain restricted plasma cell population within the schwannoma.
  • The light chain restriction and polymerase chain reaction-demonstrated monoclonality of the plasma cell population suggested the co-occurrence of a plasma cell neoplasm within a schwannoma.
  • A search for systemic disease of plasma cell origin was unremarkable.
  • [MeSH-major] Neuroma, Acoustic / pathology. Plasma Cells / pathology

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  • (PMID = 19374503.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Mathai KI, Sengupta SK, Shashivadhanan, Khanna V, Sudumbrekar SM, Sahoo PK: Hearing Preservation in a Case of Acoustic Schwannoma. Med J Armed Forces India; 2009 Jul;65(3):290-1
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  • [Title] Hearing Preservation in a Case of Acoustic Schwannoma.

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  • (PMID = 27408274.001).
  • [ISSN] 0377-1237
  • [Journal-full-title] Medical journal, Armed Forces India
  • [ISO-abbreviation] Med J Armed Forces India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC4921402
  • [Keywords] NOTNLM ; Acoustic schwannoma / Hearing conservation
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72. Park KY, Ahn JY, Lee JW, Chang JH, Huh SK: De novo intracranial aneurysm formation after Gamma Knife radiosurgery for vestibular schwannoma. J Neurosurg; 2009 Mar;110(3):540-2
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  • [Title] De novo intracranial aneurysm formation after Gamma Knife radiosurgery for vestibular schwannoma.
  • Vascular complications, including vessel occlusion and hemorrhage, can arise after radiosurgery; however, hemorrhage due to a ruptured de novo aneurysm after Gamma Knife radiosurgery (GKS) for tumor is extremely rare.
  • To the authors' knowledge, only a single case of de novo aneurysm formation after GKS for vestibular schwannoma has been previously reported.
  • In this study, they describe their experience with the treatment of a 74-year-old woman with subarachnoid hemorrhage limited to the cerebellopontine cistern, who had undergone GKS for vestibular schwannoma 5 years earlier.
  • [MeSH-major] Cerebellar Diseases / etiology. Intracranial Aneurysm / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects


73. Djalilian HR, Benson AG, Ziai K, Safai Y, Thakkar KH, Mafee MF: Radiation necrosis of the brain after radiosurgery for vestibular schwannoma. Am J Otolaryngol; 2007 Sep-Oct;28(5):338-41
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  • [Title] Radiation necrosis of the brain after radiosurgery for vestibular schwannoma.
  • OBJECTIVE: The objective of this study was to obtain a better understanding of radiation-induced brain necrosis after stereotactic radiation therapy for vestibular schwannomas.
  • MAIN OUTCOME MEASURE: The outcome measure that we evaluated was radiation-induced necrosis of the brain after stereotactic radiation therapy for a vestibular schwannoma.
  • RESULTS: Patients who undergo stereotactic radiation therapy for vestibular schwannomas are at risk for radiation-induced brain necrosis.
  • CONCLUSION: We support the development of a national database that would track the long-term complications of stereotactic radiation therapy to help patients make a more informed decision for the treatment of their vestibular schwannomas.
  • [MeSH-major] Brain Injuries / etiology. Neuroma, Acoustic / surgery. Radiation Injuries / etiology. Radiosurgery / adverse effects

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  • (PMID = 17826537.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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74. Niranjan A, Mathieu D, Flickinger JC, Kondziolka D, Lunsford LD: Hearing preservation after intracanalicular vestibular schwannoma radiosurgery. Neurosurgery; 2008 Dec;63(6):1054-62; discussion 1062-3
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  • [Title] Hearing preservation after intracanalicular vestibular schwannoma radiosurgery.
  • OBJECTIVE: Tumor control, facial function preservation, and hearing preservation are important criteria for successful management of intracanalicular vestibular schwannomas, whether observation, microsurgery, or radiosurgery is chosen.
  • We collected data prospectively to assess hearing preservation after intracanalicular vestibular schwannoma radiosurgery.
  • METHODS: Between 1987 and 2003, 96 patients (65 men and 31 women) underwent gamma knife stereotactic radiosurgery (SRS) for intracanalicular tumors.
  • The median tumor volume was 0.112 mm3 (range, 0.05-0.447 mm3), and the median margin dose was 13 Gy (range, 10-18 Gy).
  • Facial and trigeminal nerve function was preserved in all patients.
  • The tumor control rate (freedom from additional intervention) was 99.0% (95 of 96) at a median follow-up of 28 months (range, 12-144 months).
  • One patient underwent tumor resection 18 months after radiosurgery.
  • CONCLUSION: SRS is a minimally invasive first-line management option for patients with intracanalicular tumors and provides high rates of hearing preservation with minimal morbidity.
  • [MeSH-major] Hearing Loss / etiology. Hearing Loss / prevention & control. Neuroma, Acoustic / complications. Neuroma, Acoustic / surgery. Radiosurgery / methods

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  • (PMID = 19057318.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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75. Evans DG, Watson C, King A, Wallace AJ, Baser ME: Multiple meningiomas: differential involvement of the NF2 gene in children and adults. J Med Genet; 2005 Jan;42(1):45-8
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  • METHODS: Lymphocyte or tumour DNA was analysed from 46 individuals from 36 families who presented with a meningioma at age < or =15 years without vestibular schwannoma (VS), or who had multiple meningiomas in adulthood before the diagnosis of vs.
  • [MeSH-major] Genes, Neurofibromatosis 2. Meningioma / genetics. Mutation. Neuroma, Acoustic / genetics. Point Mutation

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  • (PMID = 15635074.001).
  • [ISSN] 1468-6244
  • [Journal-full-title] Journal of medical genetics
  • [ISO-abbreviation] J. Med. Genet.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1735900
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76. Thomas C, Di Maio S, Ma R, Vollans E, Chu C, Clark B, Lee R, McKenzie M, Martin M, Toyota B: Hearing preservation following fractionated stereotactic radiotherapy for vestibular schwannomas: prognostic implications of cochlear dose. J Neurosurg; 2007 Nov;107(5):917-26
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  • [Title] Hearing preservation following fractionated stereotactic radiotherapy for vestibular schwannomas: prognostic implications of cochlear dose.
  • OBJECT: The goal in this study was to evaluate hearing preservation rates and to determine prognostic factors for this outcome following fractionated stereotactic radiotherapy (FSRT) of vestibular schwannoma.
  • Permanent trigeminal and facial nerve complications were 0 and 6%, respectively.
  • Radiotherapy dose to the cochlear nucleus, patient age, sex, pre-FSRT hearing grade, tumor volume, and intracanalicular tumor volume failed to show any significance as prognostic factors.
  • [MeSH-major] Cochlea / radiation effects. Hearing. Neuroma, Acoustic / radiotherapy. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Facial Nerve / physiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prognosis. Prospective Studies. Radiation Dosage. Trigeminal Nerve / physiology

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  • (PMID = 17977261.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Lustgarten L: Use of Bioglue in translabyrinthine vestibular schwannoma surgery. Otol Neurotol; 2007 Oct;28(7):992
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of Bioglue in translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Bone Cements. Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures. Vestibulocochlear Nerve Diseases / surgery

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  • [CommentOn] Otol Neurotol. 2006 Jan;27(1):102-5 [16371855.001]
  • (PMID = 17909439.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bone Cements
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78. Swartz JD: Pathology of the vestibulocochlear nerve. Neuroimaging Clin N Am; 2008 May;18(2):321-46, x-xi
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  • [Title] Pathology of the vestibulocochlear nerve.
  • Imaging of the vestibulocochlear nerve has evolved dramatically over the past few decades.
  • This article is organized in a conventional way and covers congenital deformity of the internal auditory canal, neoplastic and pseudoneoplastic lesions, with special detailed emphasis on schwannoma of the eight cranial nerves (acoustic neuroma), nonneoplastic IAC/CPA pathology, including vascular loops, and numerous additional differential diagnostic entities, with particular emphasis on non-neoplastic meningeal disease.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Magnetic Resonance Imaging. Vestibulocochlear Nerve Diseases / pathology

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  • (PMID = 18466835.001).
  • [ISSN] 1052-5149
  • [Journal-full-title] Neuroimaging clinics of North America
  • [ISO-abbreviation] Neuroimaging Clin. N. Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 84
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79. Plotkin SR, Halpin C, Blakeley JO, Slattery WH 3rd, Welling DB, Chang SM, Loeffler JS, Harris GJ, Sorensen AG, McKenna MJ, Barker FG 2nd: Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma. J Neurooncol; 2009 May;93(1):61-77
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  • [Title] Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma.
  • Neurofibromatosis type 2 (NF2) is a tumor suppressor gene syndrome characterized by multiple schwannomas, especially vestibular schwannomas (VS), and meningiomas.
  • We also identify research goals in NF2 to facilitate future trial conduct, such as identifying the expectations for time to tumor progression and time to measurable hearing loss in untreated NF2-related VS, and the relation of both endpoints to patient prognostic factors (such as age, baseline tumor volume, and measures of disease severity).
  • These data would facilitate future use of endpoints based on stability of tumor size and hearing, which might be more appropriate for testing certain drugs.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Clinical Trials, Phase II as Topic / standards. Neurofibromatosis 2 / complications. Neurofibromatosis 2 / drug therapy. Neuroma, Acoustic / drug therapy

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  • (PMID = 19430883.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30 CA006973
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 154
  • [Other-IDs] NLM/ NIHMS573252; NLM/ PMC4036446
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80. Chen CC, Cheng PW, Tseng HM, Young YH: Posterior cranial fossa tumors in young adults. Laryngoscope; 2006 Sep;116(9):1678-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Posterior cranial fossa tumors in young adults.
  • OBJECTIVE/HYPOTHESIS: This retrospective study presents our experience on the posterior cranial fossa tumors in young adults during the past 15 years.
  • METHODS: From 1991 to 2005, 16 (0.8%) of 2,091 young adults (range, 16-29 years) with dizziness/vertigo, hearing loss, or tinnitus were diagnosed with posterior fossa tumor.
  • Diagnoses consisted of vestibular schwannoma and neurofibromatosis II in eight patients (50%), glial neoplasm (including astrocytoma, ependymoma, glioma) in four patients (25%), epidermoid cyst in three patients, and glomus jugulare tumor in one patient.
  • At study close, excluding one lost patient, three patients died as a result of recurrent or residual tumor at the primary site.
  • CONCLUSIONS: Unlike predominant medulloblastoma in children, the most frequent posterior fossa tumor in young adults is vestibular schwannoma and neurofibroma.
  • However, the second most frequent one in young adults is glial neoplasm as opposed to meningioma in adults.

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  • (PMID = 16955003.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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81. Plotkin SR, Singh MA, O'Donnell CC, Harris GJ, McClatchey AI, Halpin C: Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy. Nat Clin Pract Oncol; 2008 Aug;5(8):487-91
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  • [Title] Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy.
  • INVESTIGATIONS: Medical and neurological examination, MRI scan of the brain and spinal cord, pure-tone audiometry, NU-6 monosyllabic word test with phoneme scoring, City University of New York topic-related sentences test, noise/voice test of minimal auditory capability battery.
  • DIAGNOSIS: Progressive neurofibromatosis-type-2-related vestibular schwannomas.
  • MANAGEMENT: Annual cranial MRI and audiology, surgical resection of right vestibular schwannoma, high-power behind-the-ear hearing aid, erlotinib therapy for progressive left vestibular schwannoma.
  • [MeSH-minor] Audiometry, Pure-Tone. Auditory Threshold. Combined Modality Therapy. Erlotinib Hydrochloride. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Protein Kinase Inhibitors / administration & dosage. Treatment Outcome. Vestibular Diseases / complications. Vestibular Diseases / drug therapy. Vestibular Diseases / surgery

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  • (PMID = 18560388.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride
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82. Magliulo G, Parrotto D, Gagliardi M: Vestibular evoked myogenic and periocular potentials after vestibular schwannoma surgery. Ann Otol Rhinol Laryngol; 2008 Jan;117(1):11-4
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  • [Title] Vestibular evoked myogenic and periocular potentials after vestibular schwannoma surgery.
  • OBJECTIVES: We analyzed the behavior of preoperative and postoperative vestibular evoked myogenic potentials (VEMPs) and vestibular evoked periocular potentials (VEPPs) in 3 patients who had vestibular schwannoma and underwent modified translabyrinthine surgery.
  • METHODS: We compared VEMPs and VEPPs, measured with both air-conducted (AC) and bone-conducted (BC) stimulations.
  • Vestibular evoked potentials were measured both in the immediate postoperative period and some months later.
  • RESULTS: At the immediate postoperative examination, VEPPs were preserved in all 3 patients with both AC and BC stimulations.
  • In contrast, VEPPs were absent in 2 of our patients with AC stimulation and in 1 patient with BC stimulation.
  • In 1 patient, who had a schwannoma of the inferior vestibular nerve, the preservation of VEPPs and the absence of VEMPs in the immediate postoperative period confirm that the saccule represents the origin of VEMPs.
  • [MeSH-major] Evoked Potentials, Somatosensory / physiology. Muscle, Skeletal / physiopathology. Neuroma, Acoustic / physiopathology. Vestibule, Labyrinth / physiopathology

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  • (PMID = 18254364.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Roche PH, Ribeiro T, Fournier HD, Thomassin JM: Vestibular schwannomas: complications of microsurgery. Prog Neurol Surg; 2008;21:214-21
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  • [Title] Vestibular schwannomas: complications of microsurgery.
  • Current microsurgical treatment of vestibular schwannomas usually brings satisfactory results for the patients.
  • However, transient or permanent complications may occur, especially when treating large tumors.
  • Based on their personal experience of large operated vestibular schwannomas and analyzing a review of the international literature, the authors detail these complications and the way to prevent and manage them.
  • Lower cranial nerve deficits are unusual but may expose to early and delayed aspiration pneumonias.
  • [MeSH-major] Microsurgery / adverse effects. Neuroma, Acoustic / surgery
  • [MeSH-minor] Cerebrovascular Disorders / etiology. Cranial Nerve Diseases / etiology. Craniotomy / adverse effects. Humans. Meningitis / etiology

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  • (PMID = 18810222.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 18
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84. Cadoni G, Cianfoni A, Agostino S, Scipione S, Tartaglione T, Galli J, Colosimo C: Magnetic resonance imaging findings in sudden sensorineural hearing loss. J Otolaryngol; 2006 Oct;35(5):310-6
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  • METHODS: Fifty-four consecutive patients affected by SSNHL were investigated using brain MRI.
  • MRI was performed with an eight-channel phased-array head coil to study the entire audiovestibular pathway and the whole brain.
  • The rest of the brain was studied with a 4 mm axial T(2)-weighted FLAIR sequence.
  • In 6 of 54 cases, the detected abnormality was directly correlated to the clinical picture (2 labyrinthine hemorrhage, 1 cochlear inflammation, 1 acoustic neuroma, 1 arachnoid cyst of the CPA, and 1 case of white matter lesions in the pons, compatible with demyelinating plaques along the central audiovestibular nervous pathway, as the first expression of multiple sclerosis).
  • CONCLUSIONS: An extensive MRI study of the audiovestibular nervous pathway and of the whole brain, pre- and postparamagnetic contrast administration, is recommended to rule out the wide spectrum of abnormalities that can cause SSNHL.
  • [MeSH-minor] Adult. Aged. Arachnoid Cysts / pathology. Audiometry, Pure-Tone. Brain / pathology. Cerebellum / blood supply. Cochlea / pathology. Female. Gadolinium. Humans. Male. Middle Aged. Multiple Sclerosis / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 17049147.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] AU0V1LM3JT / Gadolinium
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85. Bozorg Grayeli A, Kalamarides M, Fraysse B, Deguine O, Favre G, Martin C, Mom T, Sterkers O: Comparison between intraoperative observations and electromyographic monitoring data for facial nerve outcome after vestibular schwannoma surgery. Acta Otolaryngol; 2005 Oct;125(10):1069-74
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  • [Title] Comparison between intraoperative observations and electromyographic monitoring data for facial nerve outcome after vestibular schwannoma surgery.
  • Determination of stimulation thresholds (STs) below 0.05 mA improves facial prognostic information after vestibular schwannoma (VS) surgery.
  • Intraoperative observations were made concerning adhesion and nerve stretch, and facial function was graded (House-Brackmann classification) at postoperative Days 1 and 8.Facial function at postoperative Days 1 and 8 was related to the intraoperative nerve STs at the brainstem and in the adhesion zone (range 0.01-3 mA for a response > 100 microV).
  • These STs were related to the degree of tumor adhesion and not to the nerve stretch.
  • [MeSH-major] Electromyography / instrumentation. Facial Nerve / pathology. Facial Nerve / physiopathology. Monitoring, Intraoperative / instrumentation. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 16298788.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Norway
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86. Goutagny S, Bouccara D, Bozorg-Grayeli A, Sterkers O, Kalamarides M: [Neurofibromatosis type 2]. Rev Neurol (Paris); 2007 Sep;163(8-9):765-77
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  • [Transliterated title] La neurofibromatose de type 2.
  • INTRODUCTION: Neurofibromatosis 2 (NF2) is a rare autosomal dominant disease whose hallmark is the development of bilateral vestibular schwannomas.
  • STATE OF THE ART: Other features of NF2 include schwannomas, meningiomas, ependymomas, localized along the central nervous system, schwannomas of the peripheral nerves, cutaneous and ophthalmological manifestations.
  • NF2 can be diagnosed in patients without bilateral vestibular schwannoma with sets of diagnostic criteria.
  • Disease phenotype is variable among patients.
  • Main negative prognostic factors are a young age at onset of symptoms and a high number of tumors at diagnosis.
  • NF2 tumor suppressor gene encodes Merlin/Schwannomin, and is also involved in most sporadic schwannomas and meningiomas.
  • Some authors advocate an early proactive strategy against vestibular schwannoma in order to preserve hearing.
  • When a treatment is advisable, surgery remains the treatment of choice for tumors.
  • [MeSH-minor] Adolescent. Adult. Brain Neoplasms / genetics. Brain Neoplasms / pathology. Child. Child, Preschool. Diagnosis, Differential. Ependymoma / epidemiology. Ependymoma / genetics. Ependymoma / pathology. Female. Genes, Tumor Suppressor. Humans. Male. Middle Aged. Neurilemmoma / genetics. Neurilemmoma / pathology. Prognosis

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  • (PMID = 17878803.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 65
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87. Tong MC, Lam JM, Hu BH, Sanna M: [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2005 Sep;40(9):705-7
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  • [Title] [Clinical experience in 36 cases of using of the extended translabyrinthine technique for the treatment of large acoustic neuromas].
  • [MeSH-major] Fenestration, Labyrinth / methods. Neuroma, Acoustic / surgery

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  • (PMID = 16335411.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] Journal Article
  • [Publication-country] China
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88. Xu J, Huang W, Liu G, Zhou J, Gao B: [Patterns of hearing disorders in normal otoacoustic emissions]. Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2005 Nov;19(22):1023-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHOD: Tests of pure tone audiometry, acoustic impedance test, auditory brainstem response (ABR), 40 Hz AERP,spontaneous otoacoustic emissions (SOAE), transient evoked otoacoustic emissions (TEOAE), distortion evoked otoacoustic emissions (DPEOAE)and imaging examinations of CT/MRI scan were performed on all 83 patients with hearing disorders.
  • (2) 2 patients with unilateral acoustic neuroma;.

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  • (PMID = 16468152.001).
  • [Journal-full-title] Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
  • [ISO-abbreviation] Lin Chuang Er Bi Yan Hou Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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89. Engh JA, Kostov D, St Martin MB, Yeaney G, Rothfus W, Hirsch B, Kassam AB: Cavernous malformation tumors: a case study and review of the literature. Otol Neurotol; 2010 Feb;31(2):294-8
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  • [Title] Cavernous malformation tumors: a case study and review of the literature.
  • METHODS: A systematic literature review on cavernous malformations of the cerebellopontine angle yielded 14 case reports relevant to the disease.
  • RESULTS: The most common clinical signs associated with this tumor are hearing loss (86.7%), followed by facial paresis (53.8%).
  • Cavernous malformations range from isointense to hyperintense to brain on noncontrasted T1 magnetic resonance imaging.
  • In general, outcomes for patients with this tumor are favorable, with most patients cured by surgical resection.
  • An understanding of the clinical and radiographic differences between this lesion and a vestibular schwannoma helps to minimize perioperative morbidity.
  • Surgical resection should be performed with special attention to preserving facial nerve function.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / pathology. Cerebellopontine Angle / surgery. Intracranial Arteriovenous Malformations / pathology. Intracranial Arteriovenous Malformations / surgery. Otologic Surgical Procedures
  • [MeSH-minor] Adolescent. Facial Paralysis / etiology. Female. Hearing Loss, Sensorineural / etiology. Humans. Magnetic Resonance Imaging. Neuroma, Acoustic / pathology. Postoperative Complications / epidemiology. Treatment Outcome

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  • (PMID = 19887972.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Gönül E, Izci Y, Onguru O: Arachnoid cyst of the cerebellopontine angle associated with gliosis of the eighth cranial nerve. J Clin Neurosci; 2007 Jul;14(7):700-2
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  • [Title] Arachnoid cyst of the cerebellopontine angle associated with gliosis of the eighth cranial nerve.
  • The clinical syndrome produced by a cyst in the cerebellopontine angle (CPA) may closely mimic that of an acoustic neuroma, with sensorineural hearing loss, impaired corneal reflex, and cerebellar signs with increased intracranial pressure.
  • Gliosis of the eighth nerve is common but its association with CPA arachnoid cyst is very rare and not previously reported.
  • We report a patient with a CPA arachnoid cyst associated with gliosis of the eighth cranial nerve.
  • He presented with right peripheral facial palsy, and gliosis of the eighth nerve was diagnosed intraoperatively.
  • CPA arachnoid cysts should be included in the differential diagnosis of peripheral facial palsy and the eighth cranial nerve should be examined during the resection and fenestration of the arachnoid cyst.
  • [MeSH-major] Arachnoid Cysts / complications. Cerebellar Neoplasms / complications. Cerebellopontine Angle / pathology. Cranial Nerve Neoplasms / complications. Gliosis / complications. Vestibulocochlear Nerve / pathology

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  • (PMID = 17475499.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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91. Vogel JJ, Godefroy WP, van der Mey AG, le Cessie S, Kaptein AA: Illness perceptions, coping, and quality of life in vestibular schwannoma patients at diagnosis. Otol Neurotol; 2008 Sep;29(6):839-45
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  • [Title] Illness perceptions, coping, and quality of life in vestibular schwannoma patients at diagnosis.
  • OBJECTIVE: To evaluate illness perceptions, coping behavior, and quality of life (QOL) in patients with vestibular schwannoma (VS) at diagnosis.
  • RESULTS: The 36-Item Short Form Health Survey scores of VS patients at diagnosis were significantly decreased when compared with healthy controls, patients with head and neck cancer, benign prostate hypertrophy, chronic obstructive pulmonary disease, and deaf patients.
  • CONCLUSION: Vestibular schwannoma patients experience impaired QOL compared with healthy controls and reference groups.
  • [MeSH-major] Adaptation, Psychological. Attitude to Health. Ear Neoplasms / diagnosis. Ear Neoplasms / pathology. Neuroma, Acoustic / diagnosis. Neuroma, Acoustic / psychology. Quality of Life / psychology

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  • (PMID = 18636026.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Otto SR, Shannon RV, Wilkinson EP, Hitselberger WE, McCreery DB, Moore JK, Brackmann DE: Audiologic outcomes with the penetrating electrode auditory brainstem implant. Otol Neurotol; 2008 Dec;29(8):1147-54
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  • PATIENTS AND PROTOCOL: In a prospective clinical trial, 10 individuals, all with neurofibromatosis type 2, received a PABI after vestibular schwannoma removal via a translabyrinthine approach.
  • [MeSH-major] Auditory Brain Stem Implants. Deafness / surgery. Hearing Aids. Hearing Tests. Neurofibromatosis 2 / complications. Prostheses and Implants
  • [MeSH-minor] Adult. Cochlear Nerve / physiopathology. Electric Stimulation. Electrodes. Equipment Design. Female. Humans. Male. Middle Aged. Pitch Perception. Treatment Outcome. Young Adult

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  • (PMID = 18931643.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / N01-DC-1-2105; United States / NIDCD NIH HHS / DC / N01-DC-4-0005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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93. Archibald DJ, Neff BA, Voss SG, Splinter PL, Driscoll CL, Link MJ, Dong H, Kwon ED: B7-H1 expression in vestibular schwannomas. Otol Neurotol; 2010 Aug;31(6):991-7
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  • [Title] B7-H1 expression in vestibular schwannomas.
  • HYPOTHESIS: B7-H1 is expressed in vestibular schwannomas.
  • BACKGROUND: Little is known about how benign human vestibular schwannomas interact with antibody-mediated or cell-mediated immunity.
  • We report on the aberrant expression of a novel T-cell coregulatory molecule, B7 homolog 1 (B7-H1), in vestibular schwannomas and discuss the implications of B7-H1 expression and tumor aggressiveness and a potential regulator of B7-H1 expression.
  • METHODS: Immunohistochemical staining for B7-H1, CD8+, CD3+, and CD4+ lymphocytes were performed on 48 fresh-frozen vestibular schwannoma tissue specimens.
  • A clinical review of patient presenting symptoms and tumor characteristics was performed.
  • Real-time polymerase chain reaction was used to determine if there was differential expression of B7-H1 messenger RNA and microRNA-513, a known regulator of B7-H1, in several strongly positive and negative B7-H1 vestibular schwannomas.
  • RESULTS: Nine (19%) of 48 tumors were negative, 23 (48%) tumors were 1+ mildly positive (<20% section area), and 16 (33%) stained 2+ strongly positive (>or=20% section area) for B7-H1.
  • The average number of CD8 cells per high-power field was 2.1 for positive-staining tumors and 1.0 for negative tumors (p = 0.16).
  • Failure of tumor control with stereotactic radiation (p = 0.029) was significantly greater in the strongly positive B7-H1 tumors.
  • Real-time polymerase chain reaction did not show significant differential expression of microRNA-513 (p = 0.62) or B7-H1 messenger RNA (p = 0.35) between the tumors showing strong and negative immunohistochemical staining for B7-H1 protein.
  • CONCLUSION: Vestibular schwannoma tumors express B7-H1, which has been associated with immune tolerance and adverse disease characteristics in several malignancies.
  • Growing tumors that were surgically removed after failed stereotactic radiation therapy were significantly more likely to strongly express B7-H1 protein, which lends some credibility to the hypothesis that immuno-evasion may play some role in their continued growth.
  • Although clinical trends were seen, greater statistical power is required to evaluate whether B7-H1 expression correlates with more aggressive tumor growth or poorer hearing class.
  • B7-H1 seems to be expressed in equal amounts at the RNA level in all vestibular schwannoma tumors that suggests that differential protein expression is occurring at the posttranscriptional level.
  • However, microRNA-513 does not regulate B7-H1 protein expression in these tumors.

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  • (PMID = 20601920.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA134345-03; United States / NCI NIH HHS / CA / R01 CA134345; United States / NCI NIH HHS / CA / R01 CA134345-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD274; 0 / CD274 protein, human; 0 / RNA, Messenger
  • [Other-IDs] NLM/ NIHMS242934; NLM/ PMC4810681
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94. Kakigi A, Nakatani H, Takeda T: Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma. ORL J Otorhinolaryngol Relat Spec; 2010;71 Suppl 1:78-84
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  • [Title] Electrocochleographic and pure-tone audiometric findings in contralateral ear of unilateral acoustic neurinoma.
  • OBJECTIVE: Auditory disorders of the contralateral ear in patients with unilateral acoustic neurinoma have previously been reported using the auditory brainstem response.
  • From our survey of the literature, there is no reported result about electrocochleography (ECoG) in the contralateral ear of acoustic neurinoma cases.
  • In the present study, we reported ECoG and pure-tone audiometric results of the contralateral ears in cases of unilateral acoustic neurinoma and the relationship between ECoG findings and tumor size was discussed.
  • METHODS: ECoG and pure-tone audiometry were performed for the contralateral ears in 27 cases of unilateral acoustic neurinoma, and the relationships between tumor size and contralateral ECoG findings and between pure-tone threshold and ECoG findings were investigated.
  • The tumor size was assessed by magnetic resonance imaging.
  • Incidences of abnormal -SP/AP ratio were 30.0% in large tumors (n = 10), 33.3% in mid-size tumors (n = 6) and 18.2% in small tumors (n = 11).
  • There was no correlation between the incidences of abnormal -SP/AP ratio and tumor size.
  • CONCLUSION: These results suggest that any size of acoustic neurinoma may affect contralateral electrocochleographic findings.
  • [MeSH-major] Audiometry, Evoked Response / methods. Audiometry, Pure-Tone. Neuroma, Acoustic / physiopathology

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  • (PMID = 20185954.001).
  • [ISSN] 1423-0275
  • [Journal-full-title] ORL; journal for oto-rhino-laryngology and its related specialties
  • [ISO-abbreviation] ORL J. Otorhinolaryngol. Relat. Spec.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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95. Neff BA, Oberstien E, Lorenz M, Chaudhury AR, Welling DB, Chang LS: Cyclin D(1) and D(3) expression in vestibular schwannomas. Laryngoscope; 2006 Mar;116(3):423-6
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  • [Title] Cyclin D(1) and D(3) expression in vestibular schwannomas.
  • OBJECTIVES: The G1 regulators of the cell cycle, cyclin D(1) and D(3), have been implicated in the regulation of Schwann cell proliferation and differentiation.
  • The purpose of this study is to evaluate cyclin D(1) and D(3) protein expression and the corresponding clinical characteristics of vestibular schwannomas.
  • STUDY DESIGN AND METHODS: Tissue sections of 15 sporadic vestibular schwannomas were prepared.
  • Immunohistochemical analysis of the vestibular schwannomas was performed with anticyclin D(1) and anticyclin D(3) antibodies.
  • The immunoreactivity was evaluated in comparison with adjacent vestibular nerves.
  • Patient demographics, tumor characteristics, and cyclin D expression were reviewed, and statistical analysis was performed.
  • RESULTS: While the breast carcinoma control expressed abundant cyclin D(1) protein, none of the 15 vestibular schwannomas showed detectable cyclin D(1) staining.
  • In contrast, seven of 15 vestibular schwannomas stained positive for the cyclin D(3) protein.
  • Cyclin D(3) staining was taken up in the nucleus of schwannoma tumor cells in greater proportion than Schwann cells of adjacent vestibular nerve.
  • Although sample size was small, no significant difference in the average age of presentation, tumor size, and male to female ratios for the cyclin D(3)(+) or cyclin D(3)(-) groups was found.
  • CONCLUSION: The Cyclin D(1) protein does not appear to play a prominent role in promoting cell cycle progression in vestibular schwannomas.
  • In contrast, cyclin D(3) expression was seen in nearly half of the tumors examined, suggesting that it may have a growth-promoting role in some schwannomas.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin D1 / biosynthesis. Cyclins / biosynthesis. Neuroma, Acoustic / metabolism
  • [MeSH-minor] Antibodies, Neoplasm / immunology. Breast Neoplasms / immunology. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Carcinoma / immunology. Carcinoma / metabolism. Carcinoma / pathology. Cyclin D3. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Prostatic Neoplasms / immunology. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology

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  • (PMID = 16540902.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Biomarkers, Tumor; 0 / CCND3 protein, human; 0 / Cyclin D3; 0 / Cyclins; 136601-57-5 / Cyclin D1
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96. Liu D, Xu D, Zhang Z, Zhang Y, Zheng L: Long-term outcomes after Gamma Knife surgery for vestibular schwannomas: a 10-year experience. J Neurosurg; 2006 Dec;105 Suppl:149-53
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  • [Title] Long-term outcomes after Gamma Knife surgery for vestibular schwannomas: a 10-year experience.
  • OBJECT: The authors sought to assess the results of Gamma Knife surgery (GKS) in patients with vestibular schwannomas (VSs).
  • Nineteen patients had undergone resection of their vs. Facial nerve function was normal in 63 patients (85.1%) before GKS, and 63.5% of them had useful hearing.
  • The mean volume of the tumor at GKS was 10.79 +/- 5.52 ml (range 0.11-27.8 ml).
  • At a median follow-up period of 68.3 months (range 30-122 months), tumor shrinkage was observed in 60 patients (81.1%), and the tumor size was stable in 11 (14.8%).
  • CONCLUSIONS: Gamma Knife surgery prevents tumor growth; it achieves excellent neurological function preservation and produces few treatment-related complications.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery. Vestibular Nerve. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Survival Analysis. Time Factors. Treatment Outcome. Tumor Burden. Young Adult

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  • (PMID = 18503349.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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97. Bozorg Grayeli A, Kalamarides M, Ferrary E, Bouccara D, El Gharem H, Rey A, Sterkers O: Conservative management versus surgery for small vestibular schwannomas. Acta Otolaryngol; 2005 Oct;125(10):1063-8
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  • [Title] Conservative management versus surgery for small vestibular schwannomas.
  • A high rate of deterioration in hearing function and the loss of patient compliance during conservative management should be taken into account when considering hearing preservation strategies for patients with vestibular schwannoma (VS).
  • [MeSH-major] Cerebellar Neoplasms / pathology. Cerebellar Neoplasms / surgery. Cerebellopontine Angle. Hearing Loss / etiology. Hearing Loss / prevention & control. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery

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  • (PMID = 16298787.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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98. Noudel R, Gomis P, Duntze J, Marnet D, Bazin A, Roche PH: Hearing preservation and facial nerve function after microsurgery for intracanalicular vestibular schwannomas: comparison of middle fossa and retrosigmoid approaches. Acta Neurochir (Wien); 2009 Aug;151(8):935-44; discussion 944-5
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  • [Title] Hearing preservation and facial nerve function after microsurgery for intracanalicular vestibular schwannomas: comparison of middle fossa and retrosigmoid approaches.
  • PURPOSE: Therapeutic options for vestibular schwannomas (VS) include microsurgery, stereotactic radiosurgery and conservative management.
  • Early treatment of intracanalicular vestibular schwannomas (IVS) may be advisable because their spontaneous course will show hearing loss in most cases.
  • Advanced microsurgical techniques and continuous intraoperative monitoring of cranial nerves may allow hearing preservation (HP) without facial nerve damage.
  • There was a trend to show that the MF approach offered a better quality of postoperative hearing (not statistically significant), whereas the RS approach offered a better facial nerve preservation and fewer complications (not statistically significant).
  • CONCLUSIONS: We believe that the timing of treatment in the course of the disease and selection between radiosurgical versus microsurgical procedure are key issues in the management of Ivs. Preservation of hearing and good facial nerve function in surgery for VS is a reasonable goal for many patients with intracanalicular tumors and serviceable hearing.
  • [MeSH-major] Craniotomy / methods. Microsurgery / methods. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Postoperative Complications / prevention & control
  • [MeSH-minor] Cranial Fossa, Middle / anatomy & histology. Cranial Fossa, Middle / surgery. Cranial Fossa, Posterior / anatomy & histology. Cranial Fossa, Posterior / surgery. Facial Nerve / anatomy & histology. Facial Nerve / surgery. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / prevention & control. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / physiopathology. Hearing Loss, Sensorineural / prevention & control. Humans. Occipital Bone / anatomy & histology. Occipital Bone / surgery. Petrous Bone / anatomy & histology. Petrous Bone / surgery. Vestibulocochlear Nerve / anatomy & histology. Vestibulocochlear Nerve / pathology. Vestibulocochlear Nerve / surgery


99. Takahashi H, Nakao M, Kaga K: Accessing ampli-tonotopic organization of rat auditory cortex by microstimulation of cochlear nucleus. IEEE Trans Biomed Eng; 2005 Jul;52(7):1333-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Auditory brainstem implants (ABI) that electrically stimulate the surface of cochlear nucleus have been clinically used for the rehabilitation of deaf patients with bilateral vestibular schwannomas.
  • Our experimental results demonstrated that microstimulation of both the dorsal and ventral cochlear nucleus (DCN and VCN) could access the cortical ampli-tonotopic organization as acoustic stimuli did.
  • [MeSH-major] Action Potentials / physiology. Auditory Cortex / physiology. Auditory Perception / physiology. Cochlear Nucleus / physiology. Deep Brain Stimulation / methods. Evoked Potentials, Auditory / physiology. Nerve Net / physiology
  • [MeSH-minor] Animals. Brain Mapping / methods. Electrodes, Implanted. Feasibility Studies. Microelectrodes. Models, Animal. Rats. Rats, Wistar

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  • (PMID = 16041997.001).
  • [ISSN] 0018-9294
  • [Journal-full-title] IEEE transactions on bio-medical engineering
  • [ISO-abbreviation] IEEE Trans Biomed Eng
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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100. Chu SM, Young YH: Ipsilateral and contralateral vestibular schwannomas in unilateral long-term deaf ears. Eur Arch Otorhinolaryngol; 2007 Jun;264(6):693-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ipsilateral and contralateral vestibular schwannomas in unilateral long-term deaf ears.
  • In the past decade, we have encountered two patients with unilateral long-term deaf ear having vestibular schwannoma.
  • Although similar physiological findings were disclosed on the deaf ears, MRI scan demonstrated vestibular schwannoma on the different side, that is, one in deaf ear and the other in hearing ear.
  • For the former, absent ABR and caloric results indicate that the tumor originates from the superior vestibular nerve.
  • In contrast with the latter, normal ABR and caloric responses, but absent vestibular-evoked myogenic potentials on the hearing ear imply that the tumor originates from the inferior vestibular nerve.
  • The ipsilateral tumor on the deaf ear underwent intracranial surgical excision, followed by radiosurgery due to tumor recurrence 10 years later, while the contralateral one on the only hearing ear received radiosurgery only.
  • [MeSH-major] Deafness. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Audiometry, Pure-Tone. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Radiosurgery / methods. Stereotaxic Techniques

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  • (PMID = 17476518.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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