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Items 1 to 68 of about 68
1. Ortigara L, Rosemberg N, Siqueira R, Neto F: Resection of a mediastinal schwannoma using video-assisted thoracoscopy. J Bras Pneumol; 2006 Mar-Apr;32(2):172-5
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  • Schwannomas are tumors that are typically benign.
  • They are derived from Schwann cells (glial cells of the peripheral nervous system that serve to separate and isolate nerve cells from adjacent structures).
  • The most common type of schwannoma is a benign tumor of cranial nerve VIII and is referred to as an acoustic neuroma.
  • When extradural, such tumors usually present as masses that can invade adjacent structures, thereby becoming symptomatic, as in the case of intrathoracic schwannomas (typically found in the posterior mediastinum).
  • [MeSH-major] Mediastinal Neoplasms / surgery. Neurilemmoma / surgery. Thoracic Surgery, Video-Assisted

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  • (PMID = 17273587.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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2. Schoemaker MJ, Swerdlow AJ, Auvinen A, Christensen HC, Feychting M, Johansen C, Klaeboe L, Lönn S, Salminen T, Tynes T: Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study. Int J Cancer; 2007 Jan 1;120(1):103-10
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  • [Title] Medical history, cigarette smoking and risk of acoustic neuroma: an international case-control study.
  • Acoustic neuroma (vestibular schwannoma) is a benign tumor of the vestibulocochlear nerve.
  • Its recorded incidence is increasing but risk factors for this tumor have scarcely been investigated.
  • We conducted a population-based case-control study of risk factors for acoustic neuroma in the UK and Nordic countries, including 563 cases and 2,703 controls.
  • Tumor risk was analyzed in relation to medical history and cigarette smoking.
  • Risk of acoustic neuroma was significantly raised in parous compared with nulliparous women (OR = 1.7, 95% CI: 1.1-2.6), but was not related to age at first birth or number of children.
  • Risk was not associated with a history of allergic disease, past head injury, past diagnosis of a neoplasm or birth characteristics, but was significantly raised for past diagnosis of epilepsy (OR = 2.5, 95% CI: 1.3-4.9).
  • Tumor risk was significantly reduced in subjects who had ever regularly smoked cigarettes (OR = 0.7, 95% CI: 0.6-0.9), but the reduction applied only to current smokers (OR = 0.5, 95% CI: 0.4-0.6), not ex-smokers (OR = 1.0, 95% CI: 0.8-1.3).
  • The reduced risk of acoustic neuroma in smokers and raised risk in parous women might relate to sex hormone levels, or smoking might suppress tumor growth, but effects of parity and smoking on timing of diagnosis of the tumor are also a potential explanation.
  • The raised risk in relation to past diagnosis of epilepsy might be a surveillance artefact or imply that epilepsy and/or antiepileptic medication use predispose to acoustic neuroma.
  • [MeSH-major] Neuroma, Acoustic / etiology. Smoking / adverse effects


3. Seol HJ, Kim CH, Park CK, Kim CH, Kim DG, Chung YS, Jung HW: Optimal extent of resection in vestibular schwannoma surgery: relationship to recurrence and facial nerve preservation. Neurol Med Chir (Tokyo); 2006 Apr;46(4):176-80; discussion 180-1
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  • [Title] Optimal extent of resection in vestibular schwannoma surgery: relationship to recurrence and facial nerve preservation.
  • Surgical treatment of vestibular schwannoma is targeted at complete removal with preserved neurological function.
  • Complete removal may cause significant deficits, whereas subtotal tumor removal is associated with a high recurrence rate.
  • The present study assessed the risk of tumor recurrence and postoperative facial nerve function in relation to the extent of surgical resection by reviewing the clinical records and radiological findings of 116 patients with vestibular schwannoma treated between 1990 and 1999.
  • Facial nerve function was graded using the modified House-Brackmann grade, and patients grouped into good (grades 1-2) and intermediate or poor (grades 3-6).
  • Immediately postoperative facial nerve function was good in 15.4% of patients after GTR, 40.6% after NTR, and 46.6% after STR.
  • The STR and NTR carried a lower risk of facial nerve palsy than GTR in the immediately postoperative stage (p=0.006 and 0.036, respectively).
  • Nevertheless, no statistical significance was observed in extent of resection and postoperative facial nerve outcome between the groups at last follow up (p=0.227).
  • GTR is the ideal surgical treatment for vestibular schwannoma, but NTR is a good option, with better facial nerve function preservation than GTR without significantly increasing the risk of recurrence.
  • [MeSH-major] Facial Nerve Injuries / etiology. Facial Paralysis / etiology. Neoplasm Recurrence, Local / etiology. Neoplasm, Residual / etiology. Neuroma, Acoustic / surgery. Postoperative Complications / etiology

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  • [CommentIn] Neurol Med Chir (Tokyo). 2006 Jun;46(6):318 [16794356.001]
  • (PMID = 16636507.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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4. Iwai Y, Yamanaka K, Kubo T, Aiba T: Gamma knife radiosurgery for intracanalicular acoustic neuromas. J Clin Neurosci; 2008 Sep;15(9):993-7
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  • [Title] Gamma knife radiosurgery for intracanalicular acoustic neuromas.
  • In the present study we reviewed our long-term experience with radiosurgery for intracanalicular acoustic neuromas.
  • The study involved 25 patients with unilateral intracanalicular acoustic neuromas.
  • The actuarial rate of tumour growth control at 5 and 10 years after radiosurgery was 96%.
  • No patients experienced post-radiosurgery facial palsy or other cranial nerve deficits.
  • Based on our study and long-term follow-up, radiosurgery can produce high rates of tumour growth control and hearing preservation for intracanalicular acoustic neuromas, and is an alternative to surgical resection given its low level of invasiveness.
  • When determining treatment for intracanalicular acoustic neuromas, the condition's benign natural course and the likelihood of hearing preservation must be taken into account.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Radiosurgery / methods. Radiosurgery / standards. Vestibulocochlear Nerve / surgery. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Disease Progression. Ear, Inner / pathology. Ear, Inner / surgery. Female. Hearing Loss, Sensorineural / etiology. Hearing Loss, Sensorineural / prevention & control. Hearing Loss, Sensorineural / surgery. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / prevention & control. Radiation Dosage. Treatment Outcome

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  • (PMID = 18617402.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Scotland
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5. Ottinger T, Lindberg R, Ekman S: Malignant acoustic schwannoma in a dog. J Vet Diagn Invest; 2009 Jan;21(1):129-32
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  • [Title] Malignant acoustic schwannoma in a dog.
  • A malignant schwannoma of the right acoustic nerve of a dog is described.
  • The neoplasm was found during necropsy of a 12-year-old, spayed, female Labrador Retriever that experienced a sudden onset of severe pain in the neck and upon opening the mouth.
  • The tumor had infiltrative growth, and the spindle-shaped neoplastic cells were arranged in sheets and concentric whorls.
  • [MeSH-major] Dog Diseases / pathology. Neuroma, Acoustic / veterinary
  • [MeSH-minor] Animals. Cochlear Nerve / pathology. Dogs. Female

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  • (PMID = 19139514.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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6. Zouari IB, Chtourou I, Ghariani M, Makni S, Khabir A, Gouiaa N, Boudawara Z, Sallemi Boudawara T: [Epithelioid schwannoma of the acoustic nerve: a case report]. Ann Pathol; 2006 Dec;26(6):450-3
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  • [Title] [Epithelioid schwannoma of the acoustic nerve: a case report].
  • Only five cases involving the eight nerve have been reported in the literature.
  • We report the sixth case of epithelioid schwannoma of the acoustic nerve diagnosed in a 57 year-old woman operated for neurinoma of the right cerebellopontine angle.
  • Histologically, the tumour was composed of round or polygonal atypic cells associated with spindle cell areas.
  • [MeSH-major] Carcinoma / pathology. Neuroma, Acoustic / pathology
  • [MeSH-minor] Humans. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 17255905.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Ki-67 Antigen
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7. Veronezi RJ, Fernandes YB, Borges G, Ramina R: Long-term facial nerve clinical evaluation following vestibular schwannoma surgery. Arq Neuropsiquiatr; 2008 Jun;66(2A):194-8
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  • [Title] Long-term facial nerve clinical evaluation following vestibular schwannoma surgery.
  • BACKGROUND: Facial function is important in accompaniment of patients operated on vestibular schwannoma (VS).
  • OBJECTIVE: To evaluate long term facial nerve function in patients undergoing VS resection and to correlate tumor size and facial function in a long-term follow-up.
  • Improvement of facial nerve function (at least of one grade) occurred in 53% in the long-term follow-up.
  • There was statistically significant difference in facial nerve outcome in long-term follow-up when tumor size was considered (p<0.05).
  • CONCLUSION: The majority of patients had improvement of FP in a long-term follow-up and tumor size was detected to be a factor associated with the postoperative prognostic.
  • [MeSH-major] Facial Paralysis / etiology. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cross-Sectional Studies. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Neurosurgical Procedures / adverse effects. Neurosurgical Procedures / methods. Postoperative Complications / prevention & control. Prognosis. Treatment Outcome

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  • (PMID = 18545781.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
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8. Penido Nde O, Tangerina RP, Kosugi EM, Abreu CE, Vasco MB: Vestibular Schwannoma: spontaneous tumor involution. Braz J Otorhinolaryngol; 2007 Nov-Dec;73(6):867-71
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  • [Title] Vestibular Schwannoma: spontaneous tumor involution.
  • The natural history of Vestibular Schwannomas (VS) is yet not totally known, but most of them have the tendency to slow growth, sometimes without any kind of symptoms during the individuals entire time.
  • Considering tumors that grow, about 70% have grown less than 2mm an year.
  • Advanced radiological diagnosis, especially magnetic resonance imaging with gadolinium helps us diagnose small and less symptomatic tumors.
  • Treatment of choice still is complete tumor resection.
  • Surgical approaches have improved considerably and have helped preserve facial nerve function and hearing.
  • Considering VSs natural history, there is a possibility for conservative treatment for these tumors, because their growth in the first year after diagnosis predicts tumor growth behavior in the next years.
  • Surgery should be done in cases of tumor growth, patients desire or symptoms worsening.
  • Moreover, in terms of postoperative sequelae, there is no difference between patients who underwent surgery immediately after diagnosis and those who underwent initial conservative treatment for these tumors.
  • [MeSH-major] Neoplasm Regression, Spontaneous / pathology. Neuroma, Acoustic / pathology

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  • (PMID = 18278239.001).
  • [ISSN] 1808-8694
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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9. Abram S, Rosenblatt P, Holcomb S: Stereotactic radiation techniques in the treatment of acoustic schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):571-88, ix
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  • [Title] Stereotactic radiation techniques in the treatment of acoustic schwannomas.
  • The goals of the treatment of acoustic schwannomas are prohibiting tumor growth and alleviation of symptoms caused by damage to local structures.
  • These symptoms-tinnitus, ataxia, and hearing loss--secondary to eighth nerve dysfunction, as well as symptoms arising from damage to adjacent structures such as the facial nerve, trigeminal nerve, or pons, can be caused by tumor growth or treatment.
  • Determination of optimal therapy must also take into account an understanding of the natural history of the disease, because acoustic schwannomas are slow-growing benign tumors that when left untreated, usually enlarge over time and cause problems.
  • [MeSH-major] Ear Neoplasms / pathology. Ear Neoplasms / radiotherapy. Neuroma, Acoustic / pathology. Neuroma, Acoustic / radiotherapy. Radiosurgery / instrumentation. Stereotaxic Techniques
  • [MeSH-minor] Algorithms. Dose Fractionation. Follow-Up Studies. Humans. Hydrocephalus / epidemiology. Magnetic Resonance Imaging. Neoplasm Invasiveness. Neurofibromatosis 2 / epidemiology. Tinnitus / epidemiology. Vertigo / epidemiology

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  • (PMID = 17544696.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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10. Iwai Y, Yamanaka K, Yamagata K, Yasui T: Surgery after radiosurgery for acoustic neuromas: surgical strategy and histological findings. Neurosurgery; 2007 Feb;60(2 Suppl 1):ONS75-82; discussion ONS82
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  • [Title] Surgery after radiosurgery for acoustic neuromas: surgical strategy and histological findings.
  • OBJECTIVE: To retrospectively review the authors' experience with surgical resections after failed radiosurgery for acoustic neuromas.
  • METHODS: The study group consisted of six patients with acoustic neuromas.
  • RESULTS: The tumors were subtotally removed (> or = 80%) in four patients and partially removed (< 80%) in the other two patients.
  • Preexisting facial nerve palsy improved in two patients and deteriorated in one patient, and one patient experienced new facial palsy.
  • Histological features were typical of acoustic schwannoma, and some tumors were associated with foamy macrophages, myxoid degeneration, and necrosis attributed to radiation effects.
  • At follow-up, the residual tumor was decreased in five patients and increased in one patient with an expanding intratumoral hematoma.
  • It must be carefully considered because of the natural regression of transient tumor swelling over time.
  • In patients with tumor enlargement several years after radiosurgery, the possibility of chronic intratumoral bleeding resulting from delayed radiation injury must be considered.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 17297369.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Limb CJ, Long DM, Niparko JK: Acoustic neuromas after failed radiation therapy: challenges of surgical salvage. Laryngoscope; 2005 Jan;115(1):93-8
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  • [Title] Acoustic neuromas after failed radiation therapy: challenges of surgical salvage.
  • OBJECTIVES: As stereotactic radiation has emerged as a treatment option for acoustic neuromas, cases that require surgical salvage after unsuccessful radiation have emerged.
  • We present a comparison of the technical challenges faced by the surgeons in the treatment of irradiated versus nonirradiated acoustic neuromas.
  • METHODS: We identified nine patients with acoustic neuromas that required surgical resection after radiation therapy.
  • Nine nonirradiated case-control subjects matched for age, sex, tumor size, and surgical approach were identified for purposes of general comparison.
  • Excessive scarring hindered identification of the facial nerve and added uncertainty as to the completeness of tumor removal.
  • Decompression of the internal auditory canal (IAC) dura and resection of neoplasm in the IAC before cerebellopontine angle dissection was required for facial nerve identification.
  • Operative time was significantly longer for irradiated cases, and facial nerve outcomes tended to be poorer, particularly when facial nerve dysfunction prompted the salvage procedure.
  • CONCLUSIONS: Surgical salvage of acoustic neuromas after radiation therapy is feasible, but it presents technical challenges beyond that associated with primary surgical therapy.
  • Poorer outcomes of postoperative cranial nerve status were caused primarily by anatomic changes at the nerve/tumor interface.
  • As surgical experience with the irradiated acoustic neuroma grows, operative observations should be incorporated into the counsel provided to patients with acoustic neuromas as they weigh different management options.
  • [MeSH-major] Neuroma, Acoustic / surgery

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  • (PMID = 15630374.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Tsutsumi T, Nakajima N, Hirose T, Watanabe K: Total-length invasion of the facial nerve by parotid carcinoma ex pleomorphic adenoma. Auris Nasus Larynx; 2009 Oct;36(5):618-22
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  • [Title] Total-length invasion of the facial nerve by parotid carcinoma ex pleomorphic adenoma.
  • A case of parotid carcinoma extending along the facial nerve up to the internal auditory canal is presented.
  • Total parotid resection with neck dissection was performed, as well as resection of the ear canal, eardrum, ossicles, and transmastoid and translabyrinthine facial nerve, and obliteration using the fascia lata and fatty tissue.
  • The facial nerve showed continuous swelling along its length with lump formation at the site of the geniculate ganglion and the internal acoustic canal.
  • Within the facial nerve, the epineurium, perineurium and endoneurium were affected throughout its length.
  • Preoperative MRI with a contrast medium revealed the site of lump formation on the facial nerve, though it did not reveal the consecutive spread of the tumor along the nerve trunk.
  • CT of the temporal bone is strongly recommended for detection of swelling of the temporal bone segment of the nerve trunk, which could provide confirming evidence of invasion by a parotid carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Adenoma, Pleomorphic / diagnosis. Facial Nerve / pathology. Parotid Gland. Salivary Gland Neoplasms / diagnosis
  • [MeSH-minor] Facial Bones / radiography. Facial Paralysis / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 19261405.001).
  • [ISSN] 1879-1476
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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13. Bouetel V, Lescanne E, François P, Jan M, Morinière S, Robier A: [Evolution of facial nerve prognosis in vestibular schwannoma surgery by translabyrinthine approach]. Rev Laryngol Otol Rhinol (Bord); 2008;129(1):27-33
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  • [Title] [Evolution of facial nerve prognosis in vestibular schwannoma surgery by translabyrinthine approach].
  • [Transliterated title] Evolution du pronostic du nerf facial dans la chirurgie du neurinome de l'acoustique par voie translabyrinthique.
  • PATIENTS AND METHODS: A series of 248 patients operated of an unilateral vestibular schwannoma has been reviewed.
  • The other factors are the hearing level, deafness duration, trigeminal nerve involved, vestibular status and ABR desynchronization.
  • CONCLUSION: The positive predictive factors are usually correlated with the size of the tumour This implies the necessity of an early diagnosis of the schwannomas.
  • [MeSH-major] Ear Neoplasms / surgery. Ear, Inner / surgery. Facial Nerve / physiology. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Evoked Potentials, Auditory, Brain Stem / physiology. Facial Nerve Diseases / diagnosis. Facial Nerve Diseases / physiopathology. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Prospective Studies. Severity of Illness Index

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  • (PMID = 18777766.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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14. Gerganov VM, Klinge PM, Nouri M, Stieglitz L, Samii M, Samii A: Prognostic clinical and radiological parameters for immediate facial nerve function following vestibular schwannoma surgery. Acta Neurochir (Wien); 2009 Jun;151(6):581-7; discussion 587
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  • [Title] Prognostic clinical and radiological parameters for immediate facial nerve function following vestibular schwannoma surgery.
  • OBJECTIVE: The paper aims to define the parameters available before surgery which could predict immediate facial nerve function after excision of a vestibular schwannoma (VS).
  • The main radiological parameters included in the study were tumour extension pattern, diameters, shape, and volume, as well as extent of bony changes of the internal auditory canal.
  • RESULTS: As the tumour stage and volume increase, facial nerve function is worse after surgery (p < 0.001 and p < 0.05, respectively).
  • Concomitantly, larger extra-meatal tumour diameters in three dimensions (sagittal, coronal and axial) led to worse function (p < 0.01).
  • Anterior and/or caudal tumour extension (p = 0.001 and p = 0.004, respectively) had more significant correlation than posterior and/or cranial extension (p = 0.022 and p = 0.353, respectively).
  • Polycyclic VS had the worst prognosis, followed by the tumours with oval shape.
  • The extent of intra-meatal tumour growth does not correlate with immediate facial nerve outcome.
  • The different angles, lengths and diameters of the internal auditory channel showed no significant correlation with facial nerve outcome.
  • Patients with headache as an initial symptom and those with gait instability and/or pre-operative poor facial nerve function had significantly worse immediate facial nerve outcome.
  • CONCLUSION: Our data suggests that the analysis of the radiological and neurological patient data prior to surgery could give reliable clues regarding the immediate post-operative facial nerve function.
  • [MeSH-major] Facial Nerve / surgery. Facial Nerve Injuries / diagnosis. Neuroma, Acoustic / surgery. Neurosurgical Procedures / methods. Postoperative Complications / diagnosis. Preoperative Care / methods
  • [MeSH-minor] Adult. Brain Stem / pathology. Brain Stem / surgery. Dissection / adverse effects. Dissection / methods. Dissection / standards. Female. Humans. Magnetic Resonance Imaging / methods. Male. Middle Aged. Neoplasm Invasiveness / diagnosis. Neoplasm Invasiveness / pathology. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / surgery. Predictive Value of Tests. Prognosis. Retrospective Studies. Severity of Illness Index

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  • (PMID = 19337682.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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15. Darwish BS, Bird PA, Goodisson DW, Bonkowski JA, MacFarlane MR: Facial nerve function and hearing preservation after retrosigmoid excision of vestibular schwannoma: Christchurch Hospital experience with 97 patients. ANZ J Surg; 2005 Oct;75(10):893-6
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  • [Title] Facial nerve function and hearing preservation after retrosigmoid excision of vestibular schwannoma: Christchurch Hospital experience with 97 patients.
  • BACKGROUND: Between January 1988 and December 2002, 97 patients underwent surgery for excision of vestibular schwannoma via the retrosigmoid approach at Christchurch Hospital.
  • METHODS: A retrospective review was undertaken of the clinical notes with emphasis on facial nerve function and hearing preservation postoperatively.
  • RESULTS: Of patients with small and medium-sized tumours, 81% had good facial nerve function at 1 year (House-Brackmann grade 1 and grade 2), 16% had moderate function (grade 3 and grade 4) and 3% had poor function (grade 5).
  • Of patients with large tumours, 22% had good facial function (grade 1 and grade 2), 37% had moderate function (grade 3 and grade 4) and 41% had poor function (grade 5 and grade 6).
  • Useful postoperative hearing was preserved in 21% of the 47 patients with tumours <3 cm and useful preoperative hearing.
  • Over this period, useful hearing was preserved in 32% of patients with small and medium-sized tumours and useful preoperative hearing.
  • CONCLUSIONS: Tumour size was an important predictor of the postoperative facial and cochlear nerve function.
  • The multidisciplinary approach to these tumours offers better results.
  • [MeSH-major] Facial Nerve / physiology. Hearing / physiology. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Adult. Auditory Threshold. Female. Hearing Loss / etiology. Humans. Male. Neoplasm Recurrence, Local. Neurofibromatosis 2 / surgery. Postoperative Complications. Retrospective Studies. Time Factors. Tinnitus / etiology. Treatment Outcome. Vertigo / etiology

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  • (PMID = 16176235.001).
  • [ISSN] 1445-1433
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
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16. Kiratli H, Yildiz S, Soylemezoğlu F: Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other. Orbit; 2008;27(6):451-4
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  • [Title] Neurofibromatosis type 2: optic nerve sheath meningioma in one orbit, intramuscular schwannoma in the other.
  • A highly unusual patient with neurofibromatosis type 2 (NF2) presenting with simultaneous bilateral orbital tumors is described.
  • Magnetic resonance imaging studies showed bilateral cerebellopontine angle tumors, a tumor surrounding the right intraorbital optic nerve, and a large left lateral orbital mass mixed with the lateral rectus muscle.
  • The histopathological diagnoses following incisional biopsies were right optic nerve sheath meningioma and left intramuscular schwannoma.
  • The left-sided orbital schwannoma and the right-sided vestibular schwannoma were treated with fractionated stereotactic radiotherapy.
  • [MeSH-major] Meningeal Neoplasms / pathology. Meningioma / pathology. Muscle Neoplasms / pathology. Neoplasms, Second Primary / pathology. Neurilemmoma / pathology. Neurofibromatosis 2 / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child. Female. Functional Laterality. Hamartoma / pathology. Humans. Magnetic Resonance Imaging. Neoplasm Proteins / analysis. Neuroma, Acoustic / chemistry. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Oculomotor Muscles / pathology. Radiosurgery. Radiotherapy, Conformal. Retinal Diseases / pathology

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  • (PMID = 19085302.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins
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17. Hours M, Bernard M, Montestrucq L, Arslan M, Bergeret A, Deltour I, Cardis E: [Cell Phones and Risk of brain and acoustic nerve tumours: the French INTERPHONE case-control study]. Rev Epidemiol Sante Publique; 2007 Oct;55(5):321-32
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  • [Title] [Cell Phones and Risk of brain and acoustic nerve tumours: the French INTERPHONE case-control study].
  • To evaluate the relationship between the use of cell phones and the development of tumors of the head, a multicentric international study (INTERPHONE), coordinated by the International Agency for Research on Cancer, was carried out in 13 countries.
  • METHODS: INTERPHONE is a case-control study focused on tumors of the brain and central nervous system: gliomas, meningiomas and neuromas of cranial nerves.
  • Eligible cases were men and women, residents of Paris or Lyon, aged 30-59, newly diagnosed with a first primary tumor between February 2001 and August 2003.
  • [MeSH-major] Brain Neoplasms / etiology. Cell Phones. Neuroma, Acoustic / etiology
  • [MeSH-minor] Adult. Case-Control Studies. Central Nervous System Neoplasms / etiology. Cranial Nerve Neoplasms / etiology. Female. Glioblastoma / etiology. Glioma / etiology. Humans. Male. Meningioma / etiology. Middle Aged. Neuroma / etiology. Risk Factors. Time Factors

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  • (PMID = 17851009.001).
  • [ISSN] 0398-7620
  • [Journal-full-title] Revue d'épidémiologie et de santé publique
  • [ISO-abbreviation] Rev Epidemiol Sante Publique
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Multicenter Study
  • [Publication-country] France
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18. Lü JR, Zou J, Wu H: [Expression and localization of merlin in vestibular schwannoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2006 Jul;41(7):501-5
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  • [Title] [Expression and localization of merlin in vestibular schwannoma].
  • OBJECTIVE: To clarify the expression and subcellular localization of merlin in vestibular schwannoma.
  • METHODS: Fifty four paraffin embedded vestibular schwannoma samples confirmed by pathology after resection were included in the study.
  • The expression of merlin in vestibular schwannoma was analyzed by immunohistochemistry.
  • Nerve tissues that were resected during surgical treatment for trigeminal neuralgia and Meniere's disease were used as control.
  • Western blotting was used to analyze the electrophoresis migration of merlin in the acoustic neuroma.
  • The expression percentage of merlin in the tumor tissue was compared with age and gender of the patients, clinical course of the tumor, tumor growth index, tumor diameter and clinical stage.
  • RESULTS: Merlin was expressed in 0 to 87.5% of the cells in vestibular schwannoma tissue with a mean of (46.66 +/- 5.75)%.
  • There was a negative correlation between merlin expression percentage and tumor growth index.
  • There were no correlations between merlin expression percentage and the age, gender, tumor diameter and clinical stage.
  • Merlin in the tumor tissue was shown by western blot to be in 65000 and 125000 positions.
  • CONCLUSIONS: Merlin was expressed in vestibular schwannoma tissue, with a different intra-cellular location.
  • Merlin might also exist as a complex with other proteins in the tumor tissue.
  • [MeSH-major] Neurofibromin 2 / metabolism. Neuroma, Acoustic / metabolism. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Young Adult

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  • (PMID = 17007372.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neurofibromin 2
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19. van Eck AT, Horstmann GA: Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma. J Neurosurg; 2005 Jan;102 Suppl:204-6
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  • [Title] Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma.
  • OBJECT: Gamma knife surgery (GKS) for vestibular schwannoma is still associated with an additional hearing loss of approximately 30%.
  • METHODS: Seventy-eight of 95 patients who entered a prospective protocol with a follow up of at least 12 months (mean 22 months) were evaluated.
  • The mean tumor volume was 2.28 cm3.
  • After a mean follow-up duration of 22 months, the magnetic resonance imaging-based tumor control rate was 87%.
  • One patient suffered transient facial nerve impairment.
  • CONCLUSIONS: Reducing the maximum dose to 20 Gy seems to be an effective treatment, which probably increases preservation of functional hearing without sacrificing the high tumor control rates achieved in radiosurgery.
  • Postradiosurgery tumor swelling occurred in 25% of the cases and was not correlated with hearing deterioration.
  • [MeSH-major] Hearing Disorders / diagnosis. Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Audiometry, Pure-Tone. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Prospective Studies. Severity of Illness Index. Time Factors. Tinnitus / etiology. Trigeminal Nerve Diseases / etiology. Trigeminal Nerve Diseases / physiopathology. Tumor Burden / radiation effects. Vertigo / etiology

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  • (PMID = 15662811.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Zhang R, Liu JP, Dai C: [Misdiagnosis of facial never tumor]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Nov;42(11):817-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Misdiagnosis of facial never tumor].
  • OBJECTIVE: To analyze the misdiagnosis of facial nerve tumor and better understand facial nerve tumor.
  • METHODS: Twenty-eight patients with facial nerve tumor were undergone surgical treatment during January 1993 to September 2006.
  • Facial nerve function was evaluated with House-Brackmann grading system.
  • Two cases were misdiagnosed as parotid tumor preoperatively.
  • They were identified as facial never tumor because the masses originated from facial nerve during the surgery and confirmed by pathological examination.
  • Four cases with unilateral facial nerve paralysis lasting from one year to eight years had been misdiagnosed as Bell palsy.
  • Two cases with recurrent facial nerve palsy were misdiagnosed as Bell palsy.
  • Finally MRI and CT demonstrated a mass at the genicular segment of facial nerve.
  • One case with hearing loss and mass in external acoustic meatus was misdiagnoses as external acoustic meatus neoplasm.
  • One case with ear discharge, tympanic membrane perforation, soft tissue mass at epitympanum was misdiagnosed as chronic suppurative otitis media, lump was found close to the horizontal segment of facial nerve intraoperatively, and then it was confirmed as facial schwannomas by pathology.
  • After admission, MRI study revealed the mass was involved in the facial nerve and parotid gland, and facial nerve tumor was suspected.
  • All the 11 cases were undergone surgery, and the diagnosis was confirmed pathologically.
  • CONCLUSIONS: Facial nerve tumor was rare and unfamiliar with most of Otologists.
  • The present study showed that the three symptoms or signs should be alert: patient presents with facial paralysis does not partially recovered within six months or patient presents with recurrent facial paralysis, CT scan and MRI should be ordered for these patients to rule out space-occupation along facial nerve.
  • Soft tissue mass associates with the horizontal or vertical segment of facial nerve should be distinguished with Cholesteatoma and otitis media while patient complains of facial paralysis.
  • Parotid neoplasm close to facial nerve should be considered it originates from facial nerve.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Diagnostic Errors. Facial Nerve Diseases / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 18300442.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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21. Koerbel A, Gharabaghi A, Safavi-Abbasi S, Tatagiba M, Samii M: Evolution of vestibular schwannoma surgery: the long journey to current success. Neurosurg Focus; 2005 Apr 15;18(4):e10
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  • [Title] Evolution of vestibular schwannoma surgery: the long journey to current success.
  • The extraordinary improvement of patient outcome after surgical treatment for vestibular schwannomas is relatively recent and has occurred mainly over the last 30 years.
  • Whereas in the past the primary goal of vestibular schwannoma management was to preserve the patient's life, the objective in vestibular schwannoma treatment today is to preserve neurological function.
  • Long-term follow-up examinations show negligible recurrence rates, indicating that the aim of preservation of nerve function does not limit the completeness of tumor removal with modern neurosurgical techniques.
  • Despite these advances in preserving the anatomical integrity of, for example, the cochlear nerve, losses of function and even deafness may occur postoperatively in some cases.
  • In this article, the authors report in detail the developments achieved in vestibular schwannoma surgery and the great clinicians to whom these results can be credited.
  • [MeSH-major] Microsurgery / history. Neuroma, Acoustic / history. Neuroma, Acoustic / surgery. Neurosurgery / history. Neurosurgical Procedures / history. Vestibulocochlear Nerve / surgery
  • [MeSH-minor] Deafness / etiology. Deafness / prevention & control. Facial Nerve Injuries / etiology. Facial Nerve Injuries / prevention & control. History, 18th Century. History, 19th Century. History, 20th Century. Humans. Neoplasm Recurrence, Local / prevention & control. Postoperative Complications / etiology. Postoperative Complications / pathology. Postoperative Complications / prevention & control. Vestibulocochlear Nerve Injuries

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  • (PMID = 15844862.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Historical Article; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 70
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22. Sciubba DM, Burdette EC, Cheng JJ, Pennant WA, Noggle JC, Petteys RJ, Alix C, Diederich CJ, Fichtinger G, Gokaslan ZL, Murphy KP: Percutaneous computed tomography fluoroscopy-guided conformal ultrasonic ablation of vertebral tumors in a rabbit tumor model. Laboratory investigation. J Neurosurg Spine; 2010 Dec;13(6):773-9
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  • [Title] Percutaneous computed tomography fluoroscopy-guided conformal ultrasonic ablation of vertebral tumors in a rabbit tumor model. Laboratory investigation.
  • OBJECT: Radiofrequency ablation (RFA) has proven to be effective for treatment of malignant and benign tumors in numerous anatomical sites outside the spine.
  • The major challenge of using RFA for spinal tumors is difficulty protecting the spinal cord and nerves from damage.
  • However, conforming ultrasound energy to match the exact anatomy of the tumor may provide successful ablation in such sensitive locations.
  • In a rabbit model of vertebral body tumor, the authors have successfully ablated tumors using an acoustic ablator placed percutaneously via computed tomography fluoroscopic (CTF) guidance.
  • At 21 days, a bone biopsy needle was placed into the geographical center of the lesion, down which an acoustic ablator was inserted.
  • Three multisensor thermocouple arrays were placed around the lesion to provide measurement of tissue temperature during ablation, at thermal doses ranging from 100 to 1,000,000 TEM (thermal equivalent minutes at 43°C), and tumor volumes were given a tumoricidal dose of acoustic energy.
  • Pathological specimens were obtained to determine the extent of tumor death and surrounding tissue damage.
  • Measured temperature distributions were used to reconstruct volumetric doses of energy delivered to tumor tissue, and such data were correlated with pathological findings.
  • The CTF guidance provided accurate placement of the acoustic ablator in all tumors, as corroborated through gross and microscopic histology.
  • Significant tumor death was noted in all specimens without collateral damage to nearby nerve tissue.
  • Tissue destruction just beyond the margin of the tumor was noted in some but not all specimens.
  • CONCLUSIONS: Using a rabbit intravertebral tumor model, the authors have successfully delivered tumoricidal doses of acoustic energy via a therapeutic ultrasound ablation probe placed percutaneously with CTF guidance.
  • The authors have thus established the first technical and preclinical feasibility study of controlled ultrasound ablation of spinal tumors in vivo.

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  • (PMID = 21121752.001).
  • [ISSN] 1547-5646
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA112852-03; United States / NCI NIH HHS / CA / R44 CA112852; United States / NCI NIH HHS / CA / R44 CA112852-03
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Sweeney P, Yajnik S, Hartsell W, Bovis G, Venkatesan J: Stereotactic radiotherapy for vestibular schwannoma. Otolaryngol Clin North Am; 2009 Aug;42(4):655-63
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  • [Title] Stereotactic radiotherapy for vestibular schwannoma.
  • Vestibular schwannomas are benign tumors of the Schwann cells of the eighth (VIII) cranial nerve.
  • Precision radiotherapy techniques used to manage these tumors include stereotactic radiotherapy (SRT), which can be delivered with either a conventional or hypofractionated regimen.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Neuroma, Acoustic / radiotherapy. Radiation Injuries / prevention & control. Radiotherapy Planning, Computer-Assisted. Stereotaxic Techniques
  • [MeSH-minor] Animals. Biopsy, Needle. Dose Fractionation. Dose-Response Relationship, Radiation. Female. Humans. Immunohistochemistry. Male. Mice. Neoplasm Staging. Prognosis. Radiobiology. Radiosurgery / adverse effects. Radiosurgery / methods. Radiotherapy Dosage. Radiotherapy, Conformal / adverse effects. Radiotherapy, Conformal / methods. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751870.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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24. Yomo S, Arkha Y, Delsanti C, Roche PH, Thomassin JM, Régis J: Repeat gamma knife surgery for regrowth of vestibular schwannomas. Neurosurgery; 2009 Jan;64(1):48-54; discussion 54-5
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  • [Title] Repeat gamma knife surgery for regrowth of vestibular schwannomas.
  • OBJECTIVE: Gamma knife surgery (GKS) has become established as a minimally invasive treatment modality for patients with vestibular schwannomas.
  • Treatment failure and/or tumor regrowth, however, is occasionally encountered, and microsurgical resection is usually warranted in such cases.
  • The goal of this study was to investigate whether repeat GKS is an effective treatment for recurrent vestibular schwannomas and to assess the conservation of residual neurological function.
  • METHODS: Between July 1992 and December 2007, 1951 patients harboring a unilateral vestibular schwannoma were treated with GKS.
  • Of these, 48 patients (2.5%) had to undergo a subsequent intervention because of progression or regrowth of the tumor.
  • The median tumor volume was 0.51 and 1.28 mL at the initial and second GKS treatments, respectively.
  • Six patients demonstrated a significant reduction in tumor volume.
  • In 1 patient, the final tumor volume was less than the initial volume.
  • The other 2 patients showed stabilization of tumor growth.
  • Neither aggravation of facial nerve dysfunction nor other neurological deficits secondary to GKS were observed.
  • CONCLUSION: This is the first report to address repeat GKS for vestibular schwannomas.
  • After long-term follow-up, repeat GKS with a low marginal dose seems to be a safe and effective treatment in selected patients harboring regrowth of small vestibular schwannomas that have previously been treated with GKS.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Radiosurgery

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  • (PMID = 19050660.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Sauvaget E, Kici S, Kania R, Herman P, Tran Ba Huy P: Sudden sensorineural hearing loss as a revealing symptom of vestibular schwannoma. Acta Otolaryngol; 2005 Jun;125(6):592-5
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  • [Title] Sudden sensorineural hearing loss as a revealing symptom of vestibular schwannoma.
  • CONCLUSIONS: Sudden sensorineural hearing loss (SSHL) is a frequent symptom of vestibular schwannoma (VS), often reveals small VSs and does not exhibit specific features.
  • Therefore, every case of SSHL should be evaluated using systematic MRI to rule out VS in order to improve hearing and preservation facial nerve function.
  • MATERIAL AND METHODS: A total of 139 consecutive unilateral VSs operated on between 2000 and 2002 were reviewed and analyzed regarding the prevalence, clinical and audiological features of SSHL and their relation to the size of the tumor.
  • Tumor size was significantly smaller in SSHL-associated VSs compared to other VSs.
  • [MeSH-major] Hearing Loss, Sudden / etiology. Neuroma, Acoustic / complications
  • [MeSH-minor] Adult. Aged. Audiometry / classification. Cohort Studies. Dizziness / etiology. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Hearing / physiology. Humans. Male. Middle Aged. Neoplasm Staging. Petrous Bone / pathology. Recovery of Function / physiology. Retrospective Studies. Tinnitus / etiology. Vertigo / etiology

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  • (PMID = 16076707.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Norway
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26. Inoue HK: Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation. J Neurosurg; 2005 Jan;102 Suppl:111-3
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  • [Title] Low-dose radiosurgery for large vestibular schwannomas: long-term results of functional preservation.
  • OBJECT: The author conducted a study to assess the long-term results obtained in patients who underwent GKS for large vestibular schwannomas (> 3 cm in diameter).
  • Facial and cochlear nerve functions were evaluated.
  • METHODS: Twenty consecutive large tumors in 18 patients (including two cases of neurofibromatosus Type 2 [NF2]) were followed for more than 6 years.
  • There were eight tumors that were more than 4 cm in maximum diameter.
  • Microsurgery had already been performed prior to GKS in 11 patients (nine recurrent and two residual tumors).
  • Fourteen of 15 tumors were stable or decreased in size.
  • Facial nerve function was preserved in all patients and hearing preserved in four of five patients with cochlear nerve function prior to radiosurgery.
  • CONCLUSIONS: Gamma knife surgery seems to have a place in the low-dose treatment of selected large vestibular schwannoma in patients with a reasonable chance of retaining facial function and pretreatment hearing level.
  • [MeSH-major] Facial Nerve / physiology. Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cochlear Nerve / physiopathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Microsurgery / instrumentation. Middle Aged. Neoplasm Recurrence, Local. Neurofibromatosis 2 / pathology. Neurofibromatosis 2 / surgery. Radiation Dosage. Time Factors

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  • (PMID = 15662791.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Charpiot A, Tringali S, Zaouche S, Ferber-Viart C, Dubreuil C: Perioperative complications after translabyrinthine removal of large or giant vestibular schwannoma: Outcomes for 123 patients. Acta Otolaryngol; 2010 Nov;130(11):1249-55
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  • [Title] Perioperative complications after translabyrinthine removal of large or giant vestibular schwannoma: Outcomes for 123 patients.
  • CONCLUSION: Large vestibular schwannomas are benign but dangerous tumors.
  • OBJECTIVE: Morbi-mortality study focused on large vestibular schwannoma surgically treated by translabyrinthine removal.
  • METHODS: This was a retrospective review of prospectively collected data in a series of 123 patients who underwent translabyrinthine removal of a large vestibular schwannoma (>4 cm in the cerebellopontine angle, stage IV).
  • In all, 4.9% of patients underwent a second surgery (for delayed hemorrhage or cerebrospinal fluid leak) during the first months after removal of a large vestibular schwannoma; 3.2% of patients experienced definitive neurologic complications (one death, one cerebellar disturbance, and two cases of 10th cranial nerve palsy).
  • [MeSH-major] Ear, Inner / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / adverse effects. Otologic Surgical Procedures / mortality
  • [MeSH-minor] Adult. Aged. Aphasia / etiology. Brain Stem / pathology. Cerebrospinal Fluid Leak. Cerebrospinal Fluid Rhinorrhea / etiology. Edema / etiology. Electromyography. Epilepsy / etiology. Facial Nerve / physiopathology. Female. Follow-Up Studies. Hematoma, Subdural / etiology. Hematoma, Subdural / surgery. Humans. Magnetic Resonance Imaging. Male. Meningitis / etiology. Middle Aged. Neoplasm Staging. Nervous System Diseases / etiology. Retrospective Studies. Survival Rate. Treatment Outcome

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  • [CommentIn] Acta Otolaryngol. 2011 Nov;131(11):1237-8 [21728749.001]
  • (PMID = 20443757.001).
  • [ISSN] 1651-2251
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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28. Lobato-Polo J, Kondziolka D, Zorro O, Kano H, Flickinger JC, Lunsford LD: Gamma knife radiosurgery in younger patients with vestibular schwannomas. Neurosurgery; 2009 Aug;65(2):294-300; discussion 300-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gamma knife radiosurgery in younger patients with vestibular schwannomas.
  • OBJECTIVE: Management options for patients with vestibular schwannoma include observation, surgical resection, stereotactic radiosurgery (SRS), and stereotactic radiation therapy.
  • We studied tumor response and clinical outcomes after SRS in such patients.
  • METHODS: We reviewed long-term outcomes in 55 patients with vestibular schwannomas.
  • The median tumor volume was 1.7 mm.
  • The median tumor margin dose was 13.0 Gy (range, 11-20 Gy).
  • At the last assessment, facial and trigeminal nerve function was preserved in 98.2% and 96.4% of patients, respectively; the only facial deficit (House-Brackmann grade III) occurred in a patient who received a tumor dose of 20 Gy early in our experience (1988).
  • No patient developed a secondary radiation-related tumor.
  • CONCLUSION: Our experience indicates that GK SRS is an effective management strategy for younger patients with vestibular schwannoma, most of whom have no additional cranial nerve dysfunction.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / statistics & numerical data. Vestibular Nerve / surgery
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Cochlear Nerve / physiopathology. Cochlear Nerve / radiation effects. Facial Nerve / physiopathology. Facial Nerve / radiation effects. Facial Nerve Injuries / epidemiology. Facial Nerve Injuries / prevention & control. Female. Hearing Loss, Sensorineural / epidemiology. Hearing Loss, Sensorineural / prevention & control. Humans. Male. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / surgery. Outcome Assessment (Health Care). Radiation Dosage. Retrospective Studies. Treatment Outcome. Trigeminal Nerve / physiopathology. Trigeminal Nerve / radiation effects. Trigeminal Nerve Diseases / epidemiology. Trigeminal Nerve Diseases / prevention & control. Young Adult

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  • (PMID = 19625908.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. De la Cruz A, Teufert KB: Transcochlear approach to cerebellopontine angle and clivus lesions: indications, results, and complications. Otol Neurotol; 2009 Apr;30(3):373-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients were grouped by whether the facial nerve was mobilized (TC, n = 15) or not (TO, n = 25).
  • MAIN OUTCOME MEASURES: Indications, postoperative outcomes, and complications including tumor removal and facial nerve status (House-Brackmann grade).
  • The remainder included tumors associated with NF2, acoustic tumors, malignancies, and other lesions.
  • Complete removal was achieved in 92.5% of tumors.
  • Of all patients, 42% and 55% had normal facial nerve function at the time of hospital discharge and follow up, respectively.
  • Moreover, 22% underwent a facial nerve reanastomosis procedure.
  • CONCLUSION: The TC and TO approaches provide access to midline intradural lesions, intradural petroclival tumors, and cerebellopontine angle tumors and cholesteatomas arising anterior to the internal auditory canal, without using brain retractors.
  • Total tumor removal, including its base and blood supply, is possible.
  • Facial weakness is frequent when the facial nerve is rerouted, but excellent facial nerve results are accomplished with the TO approach.
  • With these approaches, recurrence israre when all tumor has been removed.
  • [MeSH-major] Cerebellar Neoplasms / surgery. Cerebellopontine Angle / surgery. Cochlea / surgery. Cranial Fossa, Posterior / surgery. Neurosurgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Carotid Arteries / anatomy & histology. Child, Preschool. Data Interpretation, Statistical. Ear Canal / anatomy & histology. Ear Canal / surgery. Facial Nerve / physiology. Facial Nerve / surgery. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / surgery. Middle Aged. Neoplasm Recurrence, Local. Treatment Outcome. Young Adult

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  • (PMID = 19318889.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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30. Hori T, Okada Y, Maruyama T, Chernov M, Attia W: Endoscope-controlled removal of intrameatal vestibular schwannomas. Minim Invasive Neurosurg; 2006 Feb;49(1):25-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscope-controlled removal of intrameatal vestibular schwannomas.
  • The use of endoscopes for surgery of the cerebellopontine angle tumors is steadily obtaining widespread acceptance.
  • The objective of the present study was a laboratory and clinical evaluation of the safety of the endoscope-controlled microneurosurgical removal of the intrameatal vestibular schwannomas through a retrosigmoid approach.
  • Use of the endoscope permitted removal of the neoplasm from the most lateral part of the internal auditory canal and identification of the nerve of tumor origin.
  • In total, 28 tumors underwent total removal, and anatomical preservation of the facial nerve was attained in 31 cases.
  • Damage of the facial nerve by the endoscope was met once.
  • In 8 out of 16 patients, who showed serviceable hearing before surgery, this was preserved after tumor removal.
  • In conclusion, endoscope-controlled removal of the intrameatal vestibular schwannomas seems to be a technically feasible, effective and safe procedure.
  • [MeSH-major] Microsurgery / instrumentation. Neoplasm Recurrence, Local / surgery. Neuroendoscopes. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Cadaver. Cerebellopontine Angle. Facial Nerve / physiopathology. Feasibility Studies. Female. Hearing / physiology. Humans. Male. Middle Aged. Treatment Outcome

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  • (PMID = 16547878.001).
  • [ISSN] 0946-7211
  • [Journal-full-title] Minimally invasive neurosurgery : MIN
  • [ISO-abbreviation] Minim Invasive Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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31. Moffat D, De R, Hardy D, Moumoulidis I: Surgical management of trigeminal neuromas: a report of eight cases. J Laryngol Otol; 2006 Aug;120(8):631-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical management of trigeminal neuromas: a report of eight cases.
  • OBJECTIVE: Trigeminal neuromas are rare tumours that may involve any part of the Vth nerve complex, including extracranial peripheral divisions of the nerve.
  • A series of eight patients with intracranial trigeminal neuromas who underwent surgical management are presented.
  • METHODS: The hospital records and radiological images were reviewed with regard to clinical presentation, surgical approach, operative findings, peri-operative morbidity and neurological outcome, and percentage of tumour recurrence.
  • RESULTS: The principal presenting symptoms were those of involvement of the trigeminal nerve with sensory impairment in one or more of the three divisions.
  • Tumour location was the prime determinant of surgical approach.
  • Lateral skull base approaches were used as they are considered to be superior for identifying tumour origin, extension, and relationship to surrounding structures.
  • Total excision of the tumour was carried out in three of the eight patients.
  • In the remaining five patients some tumour was left purposely in order to minimize neurological deficit and optimize post-operative quality of life.
  • Five patients experienced symptomatic tumour recurrence and revision surgery was performed.
  • Pre-operative surgical planning allows tumour removal with preservation of important neural structures in the majority of cases.
  • For large tumours occupying both the middle and posterior cranial fossae, the retrosigmoid/retrolabyrinthine/middle cranial fossa approach provides good exposure and results in minimal brain retraction.
  • A Fisch type C approach is necessary for the largest tumours.
  • Long-term follow up with interval imaging is mandatory to exclude long-term tumour recurrence.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Trigeminal Nerve Diseases / surgery
  • [MeSH-minor] Adult. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Reoperation. Treatment Outcome. Trigeminal Nerve / pathology

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  • (PMID = 16707037.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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32. Park CK, Jung HW, Kim JE, Son YJ, Paek SH, Kim DG: Therapeutic strategy for large vestibular schwannomas. J Neurooncol; 2006 Apr;77(2):167-71
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  • [Title] Therapeutic strategy for large vestibular schwannomas.
  • Management of large vestibular schwannoma (VS) remains a difficult problem for which the extent of tumor resection and the role of radiosurgery continue to be the subject of debate.
  • The authors carefully reviewed the clinical data of 50 surgical cases of large VS, defined as tumors with an average diameter over 3 cm in magnetic resonance imaging (MRI).
  • Among the 33 patients with R-STR and STR, eight had undergone adjuvant radiosurgery for the residual mass.
  • Average tumor volume and diameter were 26.8 cm(3) (13.5-55.1) and 36.4 mm (30.0-47.2), respectively.
  • The tumor control rate and facial nerve function according to the extent of removal were analyzed.
  • The overall tumor control rate was 82%.
  • Perfect tumor control was achieved after NTR and R-STR with adjuvant radiosurgery.
  • Overall favorable outcome of facial nerve function (H-B grade 1 or 2) was achieved in 78% of the patients.
  • The facial nerve preservation rate was inversely proportional to the extent of tumor removal.
  • NTR or R-STR with adjuvant radiosurgery might be acceptable therapeutic options for large VS in terms of achieving good tumor control and functional preservation of facial nerve.
  • [MeSH-major] Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery
  • [MeSH-minor] Facial Nerve Injuries / etiology. Facial Paralysis / etiology. Humans. Neoplasm Recurrence, Local / epidemiology. Neoplasm, Residual. Treatment Outcome

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  • [Cites] Acta Otolaryngol. 2003 May;123(4):499-505 [12797585.001]
  • [Cites] Acta Neurochir (Wien). 2002 Jul;144(7):671-6; discussion 676-7 [12181700.001]
  • [Cites] Acta Neurochir (Wien). 1996;138(2):206-9 [8686546.001]
  • [Cites] Am J Otol. 1996 Jul;17(4):643-7 [8841715.001]
  • [Cites] Neurosurgery. 1997 Apr;40(4):684-94; discussion 694-5 [9092841.001]
  • [Cites] J Neurosurg. 1992 Jun;76(6):901-9 [1588422.001]
  • [Cites] Laryngoscope. 1996 Nov;106(11):1406-11 [8914910.001]
  • [Cites] J Neurosurg. 2000 May;92(5):745-59 [10794287.001]
  • [Cites] Otolaryngol Head Neck Surg. 2004 Jan;130(1):104-12 [14726918.001]
  • [Cites] Neurosurgery. 1997 Jan;40(1):11-21; discussion 21-3 [8971819.001]
  • [Cites] Neurosurgery. 2003 Oct;53(4):815-21; discussion 821-2 [14519213.001]
  • [Cites] Med J Osaka Univ. 1991 Mar;40(1-4):59-66 [1369658.001]
  • [Cites] Surg Neurol. 2003 Apr;59(4):283-9; discussion 289-91 [12748011.001]
  • [Cites] Otolaryngol Head Neck Surg. 1988 Oct;99(4):396-400 [3148889.001]
  • [Cites] J Neurosurg. 1991 Mar;74(3):422-5 [1993907.001]
  • [Cites] J Neurosurg. 1999 Apr;90(4):617-23 [10193604.001]
  • [Cites] Laryngoscope. 1987 Nov;97(11):1287-94 [3499554.001]
  • [Cites] Br J Neurosurg. 2002 Oct;16(5):448-55 [12498487.001]
  • (PMID = 16397752.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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33. Holland CT, Holland JT, Rozmanec M: Unilateral facial myokymia in a dog with an intracranial meningioma. Aust Vet J; 2010 Sep;88(9):357-61

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  • Postmortem examination identified a malignant (WHO grade III) meningioma in the right cerebellopontomedullary angle that compressed the ventrolateral cranial medulla, effaced the jugular foramen and internal acoustic meatus and extended into the facial canal of the petrous temporal bone.
  • Novel findings were the unique observation of isolated unilateral facial myokymia preceding diagnosis of a meningioma affecting facial nerve function within the caudal cranial fossa and the remarkably long duration of neurological signs (75 months) attributable to the neoplasm.
  • [MeSH-major] Dog Diseases / pathology. Facial Nerve Diseases / veterinary. Facial Paralysis / veterinary. Meningeal Neoplasms / veterinary. Meningioma / veterinary

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  • (PMID = 20726972.001).
  • [ISSN] 1751-0813
  • [Journal-full-title] Australian veterinary journal
  • [ISO-abbreviation] Aust. Vet. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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34. Cai LH, Wu H, Lü JR, Wang ZY: [Expression of S518 phosphorylated Merlin and its interaction with CD44 in vestibular schwannoma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2008 Dec;43(12):910-4
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  • [Title] [Expression of S518 phosphorylated Merlin and its interaction with CD44 in vestibular schwannoma].
  • OBJECTIVE: To investigate the impact of S518 phosphorylation in Merlin on the interaction with CD44 in vestibular schwannoma and the tumor growth.
  • METHODS: Thirty-five samples of vestibular schwannoma were identified by pathology.
  • Immunohistopathology and western blot were employed to analyze the expression and localization of S518 phosphorylated Merlin in the tumor tissues.
  • Nerve tissues that were collected during other surgical operation were used as control.
  • The expression level of S518 phosphorylated Merlin was compared with clinical stages, tumor size, clinical course and cystic degeneration.
  • RESULTS: In vestibular schwannoma, Merlin was phosphorylated at S518 and demonstrated perinuclear localization.
  • The S518 phosphorylation level was much lower in the normal control nerve tissues than that in vestibular schwannoma tissues.
  • There was no correlation between the phosphorylation level on Merlin and clinical stages, tumor size, clinical course and cystic degeneration.
  • The S518 phosphorylated Merlin bound CD44 was higher than wild-type Merlin bound CD44 in vestibular schwannoma tissues.
  • [MeSH-major] Antigens, CD44 / metabolism. Neurofibromin 2 / metabolism. Neuroma, Acoustic / metabolism
  • [MeSH-minor] Adult. Aged. Female. Genes, Neurofibromatosis 2. Humans. Male. Middle Aged. Neoplasm Staging. Phosphorylation

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  • (PMID = 19141242.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Neurofibromin 2
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35. Vachhani JA, Friedman WA: Radiosurgery in patients with bilateral vestibular schwannomas. Stereotact Funct Neurosurg; 2007;85(6):273-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery in patients with bilateral vestibular schwannomas.
  • BACKGROUND: Patients with bilateral vestibular schwannomas offer a unique opportunity to determine the effectiveness of radiosurgery.
  • By using the untreated tumor as an internal control, one can determine whether radiosurgery was able to interrupt the natural history of the treated tumor.
  • METHODS: From September 1998 to November 2004, 13 patients with neurofibromatosis type 2 had 14 tumors treated with radiosurgery at the University of Florida.
  • Actuarial statistics were used to analyze local control in both the treated and untreated tumor.
  • Actuarial local control in the treated tumors was 100% at 1 year and 92% at 2 and 5 years.
  • Only 1 of the treated tumors continued to grow.
  • In the untreated tumors, actuarial local control was 100% at 1 year, 78% at 2 years and 21% at 5 years.
  • None of the untreated tumors decreased in size.
  • CONCLUSION: In all but 1 patient with follow-up data, radiosurgery successfully prevented or reversed tumor growth.
  • Additionally, half of the untreated tumors continued to grow.
  • This study shows that radiosurgery alters the natural history of vestibular schwannomas.
  • [MeSH-major] Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery. Radiosurgery. Vestibular Nerve / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Functional Laterality. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Retrospective Studies

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  • [Copyright] (c) 2007 S. Karger AG, Basel.
  • (PMID = 17709979.001).
  • [ISSN] 1423-0372
  • [Journal-full-title] Stereotactic and functional neurosurgery
  • [ISO-abbreviation] Stereotact Funct Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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36. Kollert M, Minovi A, Mangold R, Hendus J, Draf W, Bockmühl U: [Paraganglioma of the head and neck--tumor control, functional results and quality of life]. Laryngorhinootologie; 2006 Sep;85(9):649-56
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  • [Title] [Paraganglioma of the head and neck--tumor control, functional results and quality of life].
  • These patients had follow-up examination within a clinical trial considering tumor control, functional results and for the first time neuropsychologically evaluated postoperative quality of life.
  • RESULTS: Among the 94 PG there were 19 carotid body (GCP), 12 vagal nerve (GVP) and 63 jugular-tympanal paragangliomas (JTP).
  • Of these, 87 tumors underwent surgery.
  • In 68 patients (78.1 %), the tumor could be removed completely.
  • During the follow-up period, residual or recurrent tumors were diagnosed in 17 patients (19.5 %).
  • One recurrent tumor was radiated and 3 others are under observation without showing growth tendencies.
  • Two patients died postoperatively due to borderline operations of extended tumors.
  • The quality of life after PG surgery showed a SIP of 4.8, which is comparably much better than after acoustic neuroma surgery (SIP 10.3).
  • CONCLUSION: Whereas complete tumor resection of GCP and JTP types A and B is almost ever possible without cranial nerve palsies, surgery of GVP and advanced JTP causes often severe functional deficits.
  • Nevertheless, advanced PG require an individualized therapeutic regime also including radiation and observation of tumor growth.
  • [MeSH-major] Head and Neck Neoplasms / surgery. Paraganglioma / surgery. Quality of Life
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carotid Body Tumor / surgery. Combined Modality Therapy. Cranial Nerve Neoplasms / surgery. Female. Follow-Up Studies. Glomus Jugulare Tumor / surgery. Glomus Tympanicum Tumor / surgery. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / surgery. Retrospective Studies. Time Factors. Treatment Outcome. Vagus Nerve Diseases / surgery

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  • (PMID = 16612748.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Clinical Trial; Comparative Study; English Abstract; Journal Article
  • [Publication-country] Germany
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37. Freeman SR, Ramsden RT, Saeed SR, Alzoubi FQ, Simo R, Rutherford SA, King AT: Revision surgery for residual or recurrent vestibular schwannoma. Otol Neurotol; 2007 Dec;28(8):1076-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Revision surgery for residual or recurrent vestibular schwannoma.
  • OBJECTIVE: Assess the requirement for and describe the complication rates of revision surgery for vestibular schwannoma.
  • PATIENTS: Patients undergoing surgery for vestibular schwannoma by the Manchester Neurotology Service between 1978 and 2004.
  • MAIN OUTCOME MEASURE(S): The presence of recurrent or residual tumor; necessity for further treatment; complications from revision surgery.
  • RESULTS: Primary surgery was undertaken on 1,037 tumors, with 866 total (19 recurred), 128 near-total, and 43 subtotal removals.
  • Further treatment was performed for 4 recurrent, 2 near-total, and 11 subtotal excised tumors.
  • Other complications of revision surgery included 3 patients with cerebrospinal fluid leaks, a postoperative hematoma requiring evacuation, 2 cerebrovascular accidents, and 2 patients with new cranial nerve deficits.
  • CONCLUSION: Most residual tumors after primary surgery are successfully managed with watch and rescan.
  • Tumor fragment size is the greatest determinant of revision treatment.
  • After revision surgery, tumor regrowth is much less predictable.
  • Revision surgery is usually considerably more difficult than primary surgery, with a higher complication rate, particularly with regard to the facial nerve.
  • Changing the approach for revision surgery may confer an advantage to facial nerve function.
  • [MeSH-major] Ear Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures
  • [MeSH-minor] Adolescent. Adult. Aged. Databases, Factual. Facial Nerve / pathology. Facial Nerve / physiopathology. Female. Humans. Male. Middle Aged. Postoperative Complications / epidemiology. Reoperation / adverse effects. Sex Ratio

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  • (PMID = 18043433.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Slattery WH 3rd: Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas. Otolaryngol Clin North Am; 2009 Aug;42(4):707-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microsurgery after radiosurgery or radiotherapy for vestibular schwannomas.
  • Radiosurgery or radiotherapy for vestibular schwannomas has become a common practice with a high chance for tumor control.
  • Despite the high rate of tumor control, there are some tumors that cannot be controlled with radiation therapy.
  • Surgical treatment after radiosurgery or radiotherapy may be necessary for tumors that continue to grow, or for patients who develop brainstem compressive symptoms, disabling hemifacial spasm, or hydrocephalus.
  • The House Ear Clinic (Los Angeles, California) experience with microsurgery after irradiation has demonstrated that the facial nerve is different once it has been radiated.
  • An irradiated facial nerve's regeneration potential is diminished, and the recovery from microsurgical trauma is not as robust.
  • [MeSH-major] Microsurgery / methods. Neoplasm Invasiveness / pathology. Neuroma, Acoustic / radiotherapy. Neuroma, Acoustic / surgery. Radiosurgery / methods
  • [MeSH-minor] Combined Modality Therapy. Cranial Irradiation / methods. Dose-Response Relationship, Radiation. Female. Humans. Male. Neoadjuvant Therapy. Neoplasm Staging. Postoperative Complications / mortality. Postoperative Complications / physiopathology. Prognosis. Radiotherapy Dosage. Radiotherapy, Conformal / methods. Risk Assessment. Survival Analysis. Treatment Outcome

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  • (PMID = 19751874.001).
  • [ISSN] 1557-8259
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 12
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39. Chu SM, Young YH: Ipsilateral and contralateral vestibular schwannomas in unilateral long-term deaf ears. Eur Arch Otorhinolaryngol; 2007 Jun;264(6):693-6
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  • [Title] Ipsilateral and contralateral vestibular schwannomas in unilateral long-term deaf ears.
  • In the past decade, we have encountered two patients with unilateral long-term deaf ear having vestibular schwannoma.
  • Although similar physiological findings were disclosed on the deaf ears, MRI scan demonstrated vestibular schwannoma on the different side, that is, one in deaf ear and the other in hearing ear.
  • For the former, absent ABR and caloric results indicate that the tumor originates from the superior vestibular nerve.
  • In contrast with the latter, normal ABR and caloric responses, but absent vestibular-evoked myogenic potentials on the hearing ear imply that the tumor originates from the inferior vestibular nerve.
  • The ipsilateral tumor on the deaf ear underwent intracranial surgical excision, followed by radiosurgery due to tumor recurrence 10 years later, while the contralateral one on the only hearing ear received radiosurgery only.
  • [MeSH-major] Deafness. Neuroma, Acoustic / diagnosis
  • [MeSH-minor] Audiometry, Pure-Tone. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Recurrence, Local. Radiosurgery / methods. Stereotaxic Techniques

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  • [Cites] Otolaryngol Head Neck Surg. 1987 Jan;96(1):39-42 [3118295.001]
  • [Cites] Otolaryngol Head Neck Surg. 2001 Nov;125(5):544-51 [11700458.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 2001 Jan;127(1):19-22 [11177009.001]
  • [Cites] Otolaryngol Head Neck Surg. 1995 Jul;113(1):23-31 [7603717.001]
  • [Cites] J Otolaryngol. 1980 Oct;9(5):375-80 [7452764.001]
  • [Cites] Laryngoscope. 1975 Oct;85(10):1762-6 [1186406.001]
  • [Cites] Laryngoscope. 2002 Sep;112(9):1623-6 [12352676.001]
  • [Cites] Ann Otol Rhinol Laryngol. 1978 Nov-Dec;87(6 Pt 1):743-8 [736418.001]
  • [Cites] Ann Otol Rhinol Laryngol. 1990 Nov;99(11):843-53 [2241008.001]
  • [Cites] Ann Otol Rhinol Laryngol. 1975 Nov-Dec;84(6):841-6 [1053456.001]
  • [Cites] Acta Otolaryngol Suppl. 2000;543:17-9 [10908964.001]
  • [Cites] Laryngoscope. 2002 Feb;112(2):267-71 [11889382.001]
  • (PMID = 17476518.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
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40. Wang CP, Hsu WC, Young YH: Vestibular evoked myogenic potentials in neurofibromatosis 2. Ann Otol Rhinol Laryngol; 2005 Jan;114(1 Pt 1):69-73
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  • [Title] Vestibular evoked myogenic potentials in neurofibromatosis 2.
  • Neurofibromatosis 2 (NF2) is characterized by bilateral vestibular neurofibromas.
  • Although the facial nerve, the cochlear nerve, and the superior division of the vestibular nerve can be evaluated before surgery, whether the inferior division of the vestibular nerve is affected remains undetermined without an operation.
  • A total of 7 patients with NF2 (2 men and 5 women) underwent pure tone audiometry, caloric testing, vestibular evoked myogenic potential (VEMP) testing, and magnetic resonance imaging.
  • Magnetic resonance imaging depicted space-occupying lesions in all 14 auditory canals: small tumors in 3 ears, medium tumors in 7 ears, and large tumors in 4 ears.
  • The tumor size of NF2 is related to the caloric response, but is unrelated to the mean hearing level or VEMPs.
  • In conclusion, NF2 originates from the superior vestibular nerve more often than the inferior vestibular nerve.
  • It more often infiltrates the cochlear nerve than the inferior vestibular nerve.
  • [MeSH-major] Evoked Potentials, Auditory / physiology. Neurofibromatosis 2 / physiopathology. Neuroma, Acoustic / physiopathology. Vestibular Function Tests
  • [MeSH-minor] Adolescent. Adult. Aged. Audiometry, Pure-Tone. Caloric Tests. Facial Paralysis / etiology. Female. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Nystagmus, Pathologic. Radiosurgery. Tinnitus / etiology

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  • (PMID = 15697166.001).
  • [ISSN] 0003-4894
  • [Journal-full-title] The Annals of otology, rhinology, and laryngology
  • [ISO-abbreviation] Ann. Otol. Rhinol. Laryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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41. Shuto T, Inomori S, Matsunaga S, Fujino H: Microsurgery for vestibular schwannoma after gamma knife radiosurgery. Acta Neurochir (Wien); 2008 Mar;150(3):229-34; discussion 234
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  • [Title] Microsurgery for vestibular schwannoma after gamma knife radiosurgery.
  • BACKGROUND: We evaluated the clinical characteristics of microsurgery for vestibular schwannoma (VS) after failed gamma knife radiosurgery (GKS).
  • The mean volume of tumour at GKS was 6.9 cm(3) (range, 0.5-19.7 cm(3)) and the mean prescription dose to the tumour margin was 12.3 Gy.
  • Tumour expansion involved solid enlargement in 7 patients, cystic enlargement in 3, and central necrosis in 2.
  • Identification of the facial nerve was easy in 5 operations and difficult in 7.
  • Dissection of the tumour from the facial nerve was difficult in most interventions because of severe adhesions or colour change.
  • Severe adhesions between the trigeminal nerve and the tumour was observed in 2 patients.
  • The tumour was subtotally removed except around the internal auditory canal in most patients.
  • Only one residual tumour increased in size and needed second GKS.
  • The function of the facial nerve deteriorated in 3 patients, was unchanged in 7, and improved in 2.
  • Dissection of the tumour from the facial nerve or brain stem is likely to be difficult.
  • We recommend subtotal resection without dissection of the facial nerve and tumour, because growth of the residual tumour was rare in our series.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery. Radiosurgery / methods. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Dissection / methods. Dissection / standards. Ear, Inner / anatomy & histology. Ear, Inner / pathology. Ear, Inner / surgery. Facial Nerve / pathology. Facial Nerve / physiopathology. Facial Nerve / surgery. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / prevention & control. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Neurosurgical Procedures / statistics & numerical data. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Retrospective Studies. Treatment Failure. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / physiopathology. Trigeminal Nerve / surgery

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  • (PMID = 18253695.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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42. Strauss C, Bischoff B, Romstöck J, Rachinger J, Rampp S, Prell J: Hearing preservation in medial vestibular schwannomas. J Neurosurg; 2008 Jul;109(1):70-6
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  • [Title] Hearing preservation in medial vestibular schwannomas.
  • OBJECT: Vestibular schwannomas (VSs) with no or little extension into the internal auditory canal have been addressed as a clinical subentity carrying a poor prognosis regarding hearing preservation, which is attributed to the initially asymptomatic intracisternal growth pattern.
  • METHODS: A consecutive series of 31 cases in 30 patients with medial VSs (mean size 31 mm) who underwent surgery between 1997 and 2005 via a suboccipitolateral route was evaluated with respect to pre- and postoperative cochlear nerve function, extent of tumor removal, and radiological findings.
  • Tumor removal was complete in all patients with hearing preservation, except for 2 patients with neurofibromatosis.
  • In 1 patient a recurrent tumor was completely removed 3 years after the initial procedure.
  • CONCLUSIONS: The cochlear nerve in medial VSs requires special attention due to the atypical intracisternal growth pattern.
  • Even in large tumors, hearing could be preserved in 37% of cases, since the cochlear nerve in medial schwannomas may not exhibit the adherence to the tumor capsule seen in tumors with comparable size involving the internal auditory canal.
  • [MeSH-major] Hearing / physiology. Neuroma, Acoustic / physiopathology. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Cochlear Nerve / physiopathology. Cohort Studies. Facial Nerve / physiopathology. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Recovery of Function / physiology. Treatment Outcome

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  • (PMID = 18590434.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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43. Seol HJ, Jung HW, Park SH, Hwang SK, Kim DG, Paek SH, Chung YS, Sub Lee C: Aggressive vestibular schwannomas showing postoperative rapid growth - their association with decreased p27 expression. J Neurooncol; 2005 Nov;75(2):203-7
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  • [Title] Aggressive vestibular schwannomas showing postoperative rapid growth - their association with decreased p27 expression.
  • Vestibular schwannomas (VSs) are relatively slow growing tumors.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Cranial Nerve Neoplasms / surgery. Cyclin-Dependent Kinase Inhibitor p27 / analysis. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Vestibulocochlear Nerve Diseases / pathology. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Cell Proliferation. Chi-Square Distribution. Down-Regulation. Follow-Up Studies. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Korea. Magnetic Resonance Imaging. Neoplasm Recurrence, Local. Postoperative Period. Reoperation. Retrospective Studies. Time Factors

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  • [Cites] Lancet. 1990 Mar 24;335(8691):675-9 [1969059.001]
  • [Cites] Cancer Res. 1996 Jun 1;56(11):2493-6 [8653683.001]
  • [Cites] Pathol Res Pract. 2002;198(12):813-9 [12608658.001]
  • [Cites] Laryngoscope. 1985 Jul;95(7 Pt 1):766-70 [4010413.001]
  • [Cites] Laryngoscope. 2002 Sep;112(9):1555-61 [12352662.001]
  • [Cites] Otol Neurotol. 2002 Sep;23(5):736-48 [12218628.001]
  • [Cites] Oncogene. 2000 Feb 3;19(5):661-9 [10698511.001]
  • [Cites] Neurosurgery. 2002 Dec;51(6):1381-90; discussion 1390-1 [12445343.001]
  • [Cites] Acta Neurochir (Wien). 1996;138(2):206-9 [8686546.001]
  • [Cites] Am J Pathol. 1997 Feb;150(2):401-7 [9033255.001]
  • [Cites] Cell. 1997 Feb 7;88(3):355-65 [9039262.001]
  • [Cites] Lung Cancer. 2001 Feb-Mar;31(2-3):149-55 [11165393.001]
  • [Cites] Laryngoscope. 2000 Apr;110(4):497-508 [10763994.001]
  • [Cites] Laryngoscope. 1986 Aug;96(8):825-9 [3736295.001]
  • [Cites] Endocr Pathol. 1995 Autumn;6(3):189-196 [12114739.001]
  • [Cites] Otolaryngol Head Neck Surg. 1997 Apr;116(4):426-30 [9141389.001]
  • [Cites] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8961-6 [10908665.001]
  • [Cites] Leukemia. 2000 Aug;14(8):1509-13 [10942251.001]
  • [Cites] Otolaryngol Head Neck Surg. 1985 Apr;93(2):151-5 [3921903.001]
  • [Cites] Am J Pathol. 1995 Sep;147(3):545-60 [7677168.001]
  • [Cites] Pathol Res Pract. 2002;198(7):461-7 [12234065.001]
  • [Cites] Genes Dev. 1998 Sep 15;12(18):2899-911 [9744866.001]
  • [Cites] J Neuropathol Exp Neurol. 1993 Jan;52(1):31-8 [8381161.001]
  • [Cites] Acta Otolaryngol Suppl. 1991;487:157-63 [1843579.001]
  • [Cites] Endocr Pathol. 2001 Summer;12(2):181-8 [11579684.001]
  • [Cites] Cell. 1996 May 31;85(5):733-44 [8646781.001]
  • [Cites] Acta Neurochir (Wien). 1995;134(1-2):35-9 [7668123.001]
  • [Cites] Nature. 1992 Sep 24;359(6393):295-300 [1406933.001]
  • [Cites] Br J Cancer. 1997;76(9):1119-23 [9365157.001]
  • [Cites] Oncogene. 1997 May 15;14(19):2283-9 [9178904.001]
  • [Cites] Clin Neuropathol. 2002 Mar-Apr;21(2):52-65 [12005253.001]
  • [Cites] Ai Zheng. 2002 Oct;21(10):1100-5 [12508652.001]
  • (PMID = 16283443.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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44. MacNally SP, Rutherford SA, King AT, Freeman S, Thorne J, Mawman D, O'Driscoll MP, Evans DG, Ramsden RT: Outcome from surgery for vestibular schwannomas in children. Br J Neurosurg; 2009 Jun;23(3):226-31
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  • [Title] Outcome from surgery for vestibular schwannomas in children.
  • OBJECT: A review of sporadic and NF2-related vestibular schwannoma surgery in children (under 18 years of age) with a specific interest in resection rates, recurrence, facial nerve outcomes, hearing preservation, hearing rehabilitation and genetic analysis.
  • METHODS: A retrospective analysis of prospectively collected data of 35 consecutively operated vestibular schwannomas in 29 paediatric patients that underwent 38 operations between 1992 and 2007.
  • Pre- and post-operative radiology, facial nerve function, pure tone audiogram and speech discrimination tests were performed with a mean follow-up of 4.5 years.
  • Tumour and blood mutations were analysed in 86% of patients.
  • Near total resection led to tumour recurrence in 5 out of 10 cases.
  • The facial nerve was anatomically preserved in 92%.
  • Facial nerve function was excellent to good (Grades 1-3) in 88% with outcome related to tumour size.
  • CONCLUSIONS: Surgery with complete resection results in excellent tumour control, but it is more difficult to attain total resection in NF2 with a relatively high recurrence rate of persistently growing tumours.
  • A better facial outcome is associated with smaller tumours, near-total resection and first time surgery.
  • [MeSH-major] Facial Nerve. Neurofibromatosis 2 / surgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adolescent. Auditory Brain Stem Implants. Auditory Threshold / physiology. Child. Cochlear Implants. Codon, Nonsense / genetics. Cranial Nerve Neoplasms / surgery. Facial Nerve Diseases / surgery. Female. Hearing Disorders / prevention & control. Humans. Male. Neoplasm Recurrence, Local / pathology. Outcome Assessment (Health Care). Postoperative Complications / prevention & control. Postoperative Complications / rehabilitation. Prognosis. Retrospective Studies. Speech Discrimination Tests

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  • [CommentIn] Br J Neurosurg. 2009 Jun;23(3):232-3 [19533455.001]
  • (PMID = 19533454.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Codon, Nonsense
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45. Roche PH, Khalil M, Thomassin JM: Microsurgical removal of vestibular schwannomas after failed previous microsurgery. Prog Neurol Surg; 2008;21:158-62
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  • [Title] Microsurgical removal of vestibular schwannomas after failed previous microsurgery.
  • Recurrent and regrowing large vestibular schwannomas (VSs) may require another microsurgical procedure.
  • Eight of them were supposed to have a radical surgery at the initial step, while 2 had experienced a subtotal resection.
  • Additional surgery was justified by a large-sized growing tumor in main cases and/or occurrence of new symptoms.
  • Preservation of a good facial nerve motion (H-B gd I or II) was obtained in 3 out of the 6 cases who displayed this preoperative status.
  • Excluding the facial nerve injury, no major complication was observed in these cases.
  • Assuming that radiosurgery is an effective tool to control small- to middle-sized VSs, priority was recently given to the facial nerve preservation during the surgical removal of recurrent and regrowing VSs.
  • [MeSH-major] Microsurgery. Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Neoplasm, Residual. Reoperation. Retrospective Studies. Treatment Failure. Tumor Burden

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  • (PMID = 18810214.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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46. Roche PH, Ribeiro T, Khalil M, Soumare O, Thomassin JM, Pellet W: Recurrence of vestibular schwannomas after surgery. Prog Neurol Surg; 2008;21:89-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrence of vestibular schwannomas after surgery.
  • The issue of recurrence of vestibular schwannomas is poorly studied by the surgical literature and is probably underestimated.
  • This long-term event is mainly due to regrowth of microfragments that have been left in the operative field along the course of the facial nerve or at the surface of the pons.
  • Management of recurrence depends on the tumor size and patient's condition.
  • Prospective long-term follow-up studies using serial MR imaging after radical removal should bring reliable data about the incidence of vestibular schwannoma recurrence.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Neuroma, Acoustic / surgery

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  • (PMID = 18810204.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 7
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47. Neff BA, Oberstien E, Lorenz M, Chaudhury AR, Welling DB, Chang LS: Cyclin D(1) and D(3) expression in vestibular schwannomas. Laryngoscope; 2006 Mar;116(3):423-6
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  • [Title] Cyclin D(1) and D(3) expression in vestibular schwannomas.
  • The purpose of this study is to evaluate cyclin D(1) and D(3) protein expression and the corresponding clinical characteristics of vestibular schwannomas.
  • STUDY DESIGN AND METHODS: Tissue sections of 15 sporadic vestibular schwannomas were prepared.
  • Immunohistochemical analysis of the vestibular schwannomas was performed with anticyclin D(1) and anticyclin D(3) antibodies.
  • The immunoreactivity was evaluated in comparison with adjacent vestibular nerves.
  • Patient demographics, tumor characteristics, and cyclin D expression were reviewed, and statistical analysis was performed.
  • RESULTS: While the breast carcinoma control expressed abundant cyclin D(1) protein, none of the 15 vestibular schwannomas showed detectable cyclin D(1) staining.
  • In contrast, seven of 15 vestibular schwannomas stained positive for the cyclin D(3) protein.
  • Cyclin D(3) staining was taken up in the nucleus of schwannoma tumor cells in greater proportion than Schwann cells of adjacent vestibular nerve.
  • Although sample size was small, no significant difference in the average age of presentation, tumor size, and male to female ratios for the cyclin D(3)(+) or cyclin D(3)(-) groups was found.
  • CONCLUSION: The Cyclin D(1) protein does not appear to play a prominent role in promoting cell cycle progression in vestibular schwannomas.
  • In contrast, cyclin D(3) expression was seen in nearly half of the tumors examined, suggesting that it may have a growth-promoting role in some schwannomas.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Cyclin D1 / biosynthesis. Cyclins / biosynthesis. Neuroma, Acoustic / metabolism
  • [MeSH-minor] Antibodies, Neoplasm / immunology. Breast Neoplasms / immunology. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Carcinoma / immunology. Carcinoma / metabolism. Carcinoma / pathology. Cyclin D3. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Prostatic Neoplasms / immunology. Prostatic Neoplasms / metabolism. Prostatic Neoplasms / pathology

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  • (PMID = 16540902.001).
  • [ISSN] 0023-852X
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Biomarkers, Tumor; 0 / CCND3 protein, human; 0 / Cyclin D3; 0 / Cyclins; 136601-57-5 / Cyclin D1
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48. Bennett M, Haynes DS: Surgical approaches and complications in the removal of vestibular schwannomas. Otolaryngol Clin North Am; 2007 Jun;40(3):589-609, ix-x
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical approaches and complications in the removal of vestibular schwannomas.
  • Vestibular schwannomas are benign tumors that usually originate from the balance portion of cranial nerve VIII.
  • The treatment options currently available for vestibular schwannomas include observation with serial imaging, stereotactic radiation, and microsurgical removal.
  • Although the ultimate goal in treatment of vestibular schwannomas is preservation of life, the best option for each patient depends on symptoms, tumor size, tumor location, and the patient's general health and age.
  • Surgical exposure of the cerebellopontine angle for removal of vestibular schwannomas can be performed safely via a translabyrinthine, retrosigmoid, and middle fossa approach.
  • The goal of surgery is complete eradication of tumor with preservation of hearing and facial nerve function when possible.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Otologic Surgical Procedures / methods
  • [MeSH-minor] Cerebrospinal Fluid Otorrhea / epidemiology. Cerebrospinal Fluid Otorrhea / etiology. Facial Nerve Diseases / epidemiology. Facial Nerve Diseases / etiology. Headache / epidemiology. Headache / etiology. Humans. Meningitis / epidemiology. Meningitis / etiology. Neoplasm Recurrence, Local. Postoperative Complications. Postural Balance / physiology. Tinnitus / epidemiology. Tinnitus / etiology

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  • (PMID = 17544697.001).
  • [ISSN] 0030-6665
  • [Journal-full-title] Otolaryngologic clinics of North America
  • [ISO-abbreviation] Otolaryngol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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49. Diensthuber M, Lenarz T, Stöver T: [Neurotrophic factor expression in vestibular schwannoma. An overview]. Laryngorhinootologie; 2006 Oct;85(10):731-7
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  • [Title] [Neurotrophic factor expression in vestibular schwannoma. An overview].
  • The vestibular schwannoma is a benign, slow-growing neoplasm that originates from the neurolemmal sheath of the vestibular branch of the VIIIth cranial nerve.
  • This tumor entity accounts for 6 % of all intracranial tumors and the annual incidence of newly diagnosed vestibular schwannoma is reported as 13 per million.
  • The molecular pathogenesis of both sporadic vestibular schwannoma and those occurring in neurofibromatosis type II appears to be associated with an aberration of a tumor suppressor gene on chromosome 22q12.
  • The biological background for the various growth patterns of vestibular schwannoma is, however, largely unknown.
  • This differing clinical and biological behaviour of vestibular schwannoma may be explained by the presence of neurotrophic factors.
  • The results of recent immunohistochemical studies demonstrate the co-expression of transforming growth factor (TGF)-beta 1 and glial cell line-derived neurotrophic factor (GDNF) in vestibular schwannoma and suggest a trophic synergism of both neurotrophic factors in this tumor.
  • Moreover, expression of numerous different neurotrophic factors has been shown in studies of nerve growth factor (NGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), neuregulin (NRG) and erythropoietin (EPO) indicating a biological role in development, maintainance or growth of vestibular schwannoma.
  • In this article, we summarize the findings on neurotrophic factor expression and discuss their characteristics and biological role in vestibular schwannoma.
  • [MeSH-major] Nerve Growth Factors / metabolism. Neuroma, Acoustic / metabolism. Neuroma, Acoustic / pathology
  • [MeSH-minor] Adult. Animals. Chromosomes, Human, Pair 22 / genetics. Epidermal Growth Factor / metabolism. Epidermal Growth Factor / physiology. Fibroblast Growth Factors / metabolism. Fibroblast Growth Factors / physiology. Genes, Tumor Suppressor. Glial Cell Line-Derived Neurotrophic Factor / metabolism. Glial Cell Line-Derived Neurotrophic Factor / physiology. Humans. Immunohistochemistry. Incidence. Mice. Mice, Hairless. Neurofibromatosis 2 / genetics. Neurofibromatosis 2 / metabolism. Neurofibromatosis 2 / pathology. Schwann Cells / metabolism. Schwann Cells / pathology. Signal Transduction. Transforming Growth Factors / metabolism. Transforming Growth Factors / physiology. Tumor Cells, Cultured. Vascular Endothelial Growth Factor A / metabolism. Vascular Endothelial Growth Factor A / physiology

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  • (PMID = 16612755.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Glial Cell Line-Derived Neurotrophic Factor; 0 / Nerve Growth Factors; 0 / Vascular Endothelial Growth Factor A; 62031-54-3 / Fibroblast Growth Factors; 62229-50-9 / Epidermal Growth Factor; 76057-06-2 / Transforming Growth Factors
  • [Number-of-references] 78
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50. Sone M, Katayama N, Otake N, Sato E, Fujimoto Y, Ito M, Nakashima T: Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals. J Clin Neurosci; 2007 May;14(5):470-3

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  • [Title] Characterizing the auditory changes in tumor metastasis to the bilateral internal auditory canals.
  • We report the changes in auditory function in a patient with tumor metastasis to the bilateral internal auditory canals (IAC).
  • However, distortion product otoacoustic emissions (DPOAE) were present at low frequencies, which suggests that the organ of Corti in its upper turn remained unaffected by tumor invasion.
  • Metastatic tumors in the bilateral IAC have been reported to mimic neurofibromatosis type 2, and radiological differentiation from acoustic schwannoma is difficult.
  • We characterize the hearing deterioration caused by metastasis of malignant tumors in the IAC.
  • [MeSH-major] Cranial Nerve Neoplasms / physiopathology. Evoked Potentials, Auditory, Brain Stem / physiology. Neoplasm Metastasis / physiopathology. Otoacoustic Emissions, Spontaneous / physiology
  • [MeSH-minor] Acoustic Stimulation / methods. Adenocarcinoma / pathology. Gastrointestinal Neoplasms / pathology. Humans. Male. Middle Aged

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  • (PMID = 17386369.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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51. Jacob A, Lee TX, Neff BA, Miller S, Welling B, Chang LS: Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma. Otol Neurotol; 2008 Jan;29(1):58-68
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Phosphatidylinositol 3-kinase/AKT pathway activation in human vestibular schwannoma.
  • HYPOTHESIS: The neurofibromatosis 2 gene, which encodes the tumor suppressor protein merlin, is frequently mutated in vestibular schwannomas (VS).
  • BACKGROUND: Despite advances in diagnosis and treatment, VS continue to cause patient morbidity.
  • METHODS: Complementary deoxyribonucleic acid microarrays were performed using cultured Schwann cells, 4 VS specimens, and 2 paired normal vestibular nerves.
  • RESULTS: Microarray analysis demonstrated that total AKT gene expression was upregulated in VS, compared with normal vestibular nerves.
  • Immunohistochemical analysis of 14 VS tissue sections detected positive staining for activated AKT phosphorylated at both serine-473 and threonine-308 in all tumors.
  • Western blots comparing VS specimens with normal vestibular nerves showed that the AKT pathway was activated in VS but not in normal nerve.
  • [MeSH-major] Neuroma, Acoustic / genetics. Oncogene Protein v-akt / genetics. Peripheral Nervous System Neoplasms / genetics. Phosphatidylinositol 3-Kinases / genetics. Signal Transduction / physiology
  • [MeSH-minor] Blotting, Western. Colforsin / pharmacology. DNA, Neoplasm / genetics. Humans. Immunohistochemistry. Oligonucleotide Array Sequence Analysis. Paraffin Embedding. Tubulin / genetics. Tumor Cells, Cultured. Xenograft Model Antitumor Assays

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  • (PMID = 18199958.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Tubulin; 1F7A44V6OU / Colforsin; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Oncogene Protein v-akt
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52. Freye E: Cerebral monitoring in the operating room and the intensive care unit - an introductory for the clinician and a guide for the novice wanting to open a window to the brain. Part II: Sensory-evoked potentials (SSEP, AEP, VEP). J Clin Monit Comput; 2005 Apr;19(1-2):77-168
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  • An evoked potential is the brain's response to a repetitive stimulus along a specific nerve pathway.
  • 7. Operation on peripheral nerves and nerve roots to identify early trauma.
  • The generation of potential changes at various sites along the pathway is an index for the integrity of the nerve.
  • Thus, the evoked potential can be considered a neurophysiological response (usually of the cortex) to impulses originating from some externally stimulated sensory nerve.
  • They provide a physiological measure of the functional integrity of the sensory nerve pathway, which can be used as a clinical diagnostic tool as well as for intraoperative monitoring.
  • If the auditory nerve is stimulated by "clicks" from headphones, it is called the auditory evoked potential (AEP).
  • If a nerve on the arm or the leg is stimulated by a small electrical current applied to the overlying skin, it is called the Somatosensory Evoked Potential (SSEP).
  • As diagnostic tests, evoked potentials are useful to evaluate neurologic disorders such as: a) multiple sclerosis, b) acoustic nerve tumors, and c) optic neuritis.

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  • [Cites] Br J Anaesth. 1989 Sep;63(3):357-9 [2803895.001]
  • [Cites] Neurosurgery. 1982 Oct;11(4):556-75 [6755296.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1981 Jun;51(6):579-88 [6165559.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1984 Nov;58(5):400-7 [6208006.001]
  • [Cites] J Neurol. 1979 Mar 22;220(2):95-8 [87502.001]
  • [Cites] Med Eng Phys. 1998 Dec;20(10):722-8 [10223640.001]
  • [Cites] Neurology. 1981 Mar;31(3):248-56 [7193818.001]
  • [Cites] Anesth Analg. 1990 Sep;71(3):225-30 [2393105.001]
  • [Cites] Neurosurgery. 1983 May;12(5):496-502 [6866230.001]
  • [Cites] Funct Neurol. 1987 Jul-Sep;2(3):281-92 [2826307.001]
  • [Cites] J Neurol Sci. 1983 Sep;61(1):49-63 [6631452.001]
  • [Cites] Neurology. 1979 Jan;29(1):38-44 [570675.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1986 Jan;65(1):46-58 [2416546.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1992 Jul-Aug;84(4):301-14 [1377999.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1973 Sep;35(3):301-9 [4126181.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1980 Dec;50(5-6):382-403 [6160982.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1981 May;51(5):477-82 [6165547.001]
  • [Cites] Pain. 1982;14(4):327-37 [7162837.001]
  • [Cites] Anasthesiol Intensivmed Notfallmed Schmerzther. 1991 Nov;26(7):384-8 [1772937.001]
  • [Cites] J Neurol Neurosurg Psychiatry. 1986 Mar;49(3):251-7 [3958738.001]
  • [Cites] J Neurosurg. 1986 Apr;64(4):633-42 [3950746.001]
  • [Cites] J Neurosurg. 1985 Jan;62(1):25-30 [2981102.001]
  • [Cites] Ann N Y Acad Sci. 1982;388:308-26 [6953874.001]
  • [Cites] Electroencephalogr Clin Neurophysiol. 1954 Feb;6(1):65-84 [13141922.001]
  • (PMID = 16167223.001).
  • [ISSN] 1387-1307
  • [Journal-full-title] Journal of clinical monitoring and computing
  • [ISO-abbreviation] J Clin Monit Comput
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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53. Dagain A, Dutertre G, Pouit B, Dulou R, Delmas JM, Poncet JL, Desgeorges M, Pernot P: [Recurrent giant cystic vestibular schwannomas: role of cystoperitoneal shunt]. Neurochirurgie; 2010 Aug;56(4):350-5
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  • [Title] [Recurrent giant cystic vestibular schwannomas: role of cystoperitoneal shunt].
  • INTRODUCTION: Surgical removal of giant cystic vestibular schwannomas is difficult because of adherences between the cyst membrane, brainstem, and the VII-VIII nerve complex.
  • The aim of this study was to analyze the role of the palliative cystoperitoneal shunt in giant cystic vestibular schwannomas.
  • MATERIALS AND METHODS: Eighty-eight patients with a diagnosis of stage III or IV vestibular schwannoma were managed surgically from January 2000 to December 2005 in our department.
  • RESULTS: Complete tumor removal was achieved in two patients.
  • [MeSH-major] Ear Neoplasms / surgery. Neuroma, Acoustic / surgery. Neurosurgical Procedures
  • [MeSH-minor] Aged. Aged, 80 and over. Central Nervous System Cysts / pathology. Central Nervous System Cysts / surgery. Drainage. Facial Nerve / pathology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local. Nerve Compression Syndromes / etiology. Nerve Compression Syndromes / surgery. Palliative Care. Peritoneum / surgery. Treatment Failure

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20557908.001).
  • [ISSN] 1773-0619
  • [Journal-full-title] Neuro-Chirurgie
  • [ISO-abbreviation] Neurochirurgie
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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54. Linskey ME: Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters? J Neurosurg; 2008 Dec;109 Suppl:129-36
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  • [Title] Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters?
  • Stereotactic radiosurgery (SRS) for vestibular schwannomas has evolved and improved over time.
  • Although early short-term follow-up reports suggest that fractionation yields hearing preservation rates equivalent to modern single-dose SRS techniques, significant questions remain regarding long-term tumor control after the use of fractionation in a late responding tumor with a low proliferative index and alpha/beta ratio.
  • 2) careful delineation of the 3D tumor margin to exclude the cochlear nerve when visualizable with contrast-enhanced T2-weighted MR volumetric imaging techniques and exclusion the dura mater of the anterior border of the internal auditory canal;.
  • 3) a tumor margin dose prescription <or= 12 Gy;.
  • 4) optimization of the tumor treatment gradient index without sacrificing coverage and conformality; and 5) strict attention to prescription dose 3D conformality so that the modiolus and the basal turn of the cochlea receive the lowest possible dose (ideally < 4-5.33 Gy).
  • [MeSH-major] Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Ear, Inner / pathology. Humans. Neoplasm Invasiveness. Radiotherapy Dosage. Tumor Burden

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  • (PMID = 19123899.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 38
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55. Wickremesekera A, Hovens CM, Kaye AH: Expression of ErbB-1 and 2 in vestibular schwannomas. J Clin Neurosci; 2007 Dec;14(12):1199-206
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  • [Title] Expression of ErbB-1 and 2 in vestibular schwannomas.
  • ErbB-1 and 2 are receptor tyrosine kinases expressed in malignant tumours.
  • Using immunohistochemistry and Western blot techniques we have shown an increased expression of ErbB-2 and no expression of ErbB-1 in vestibular schwannomas (VS).
  • [MeSH-major] Cranial Nerve Neoplasms / metabolism. Neuroma, Acoustic / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Receptor, ErbB-2 / biosynthesis
  • [MeSH-minor] Animals. Blotting, Western. Brain Neoplasms / metabolism. Brain Neoplasms / pathology. Cells, Cultured. Glioblastoma / metabolism. Glioblastoma / pathology. Humans. Immunohistochemistry. Immunoprecipitation. Mice. Neoplasm Proteins / chemistry. Neoplasm Proteins / isolation & purification

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  • (PMID = 17964790.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Neoplasm Proteins; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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56. Menon G, Nair S, Sudhir J, Rao BR, Mathew A, Bahuleyan B: Childhood and adolescent meningiomas: a report of 38 cases and review of literature. Acta Neurochir (Wien); 2009 Mar;151(3):239-44; discussion 244
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  • Eleven children (28.9%) had evidence of NF of whom three had NF2 with bilateral vestibular schwannomas.
  • The location of the operated tumours were as follows: ten skull base (24.4%), ten falx/parasagittal (24.4%), eight spinal (19.5%), five convexity (12.2%), three posterior fossa (7.3%), three intraventricular (7.3%) and two optic nerve sheath (4.9%).
  • Grade I excision was achieved only in twenty tumours (48.8%).
  • Seven tumours recurred of which six were located at the skull base.
  • Uniform observations made in different series including ours, include a higher incidence of the skull base location and tumours with atypical histopathology.
  • [MeSH-major] Meningeal Neoplasms / epidemiology. Meningeal Neoplasms / surgery. Meningioma / epidemiology. Meningioma / surgery. Neurofibromatoses / epidemiology. Skull / surgery
  • [MeSH-minor] Adolescent. Age Factors. Child. Comorbidity. Dura Mater / pathology. Dura Mater / surgery. Female. Humans. Intracranial Hypertension / etiology. Male. Neoplasm Recurrence, Local / epidemiology. Neuroma, Acoustic / epidemiology. Neurosurgical Procedures. Optic Nerve / pathology. Retrospective Studies. Seizures / etiology. Skull Base Neoplasms / epidemiology. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery. Spinal Neoplasms / epidemiology. Spinal Neoplasms / pathology. Spinal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 19238320.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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57. Stankovic KM, Mrugala MM, Martuza RL, Silver M, Betensky RA, Nadol JB Jr, Stemmer-Rachamimov AO: Genetic determinants of hearing loss associated with vestibular schwannomas. Otol Neurotol; 2009 Aug;30(5):661-7
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  • [Title] Genetic determinants of hearing loss associated with vestibular schwannomas.
  • HYPOTHESIS: The severity of hearing loss (HL) associated with vestibular schwannomas (VSs) is influenced by genes expressed by the VSs.
  • Previous studies have suggested that VSs cause HL not only by inducing degeneration of the auditory nerve by compression but also by promoting degeneration of the inner ear.
  • Because of a small sample size, exact nonparametric tests were used to assess the association between good versus poor hearing and specific histological features of the tumors and patient demographics.
  • RESULTS: Using gene set enrichment analysis, the chromosomal region 3q27 was found to be significantly different between the 2 groups of tumors.
  • [MeSH-major] Genes, Neoplasm / genetics. Hearing Loss / etiology. Hearing Loss / genetics. Neuroma, Acoustic / complications. Neuroma, Acoustic / genetics

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  • (PMID = 19546833.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 63231-63-0 / RNA; 9007-49-2 / DNA
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58. Nguyen DQ, Boulat E, Troussier J, Reyt EI, Lavieille JP, Schmerber SI: [The jugulotympanic paragangliomas: 41 cases report]. Rev Laryngol Otol Rhinol (Bord); 2005;126(1):7-13

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  • OBJECTIVE: The jugulotympanic paragangliomas (JTP) represents the most frequent tumour of the middle ear but also of the temporal bone, after the acoustic neurinoma.
  • The management of these vascular tumours remains uncleared.
  • RESULTS: A total tumor removal without recurrence was achieved by surgery in more than 95% of the cases with 6 years follow-up but was associated with significant morbidity (major cranial nerve injury).
  • We noticed one death by laryngospasme (C2Di2 tumour operated by infratemporal A approach).
  • A stabilization of the tumour was obtained with radiotherapy in first intention in 75% of the cases (5 years follow-up) but with a risk of radionecrosis.
  • Because of the slow rate of growth, the radiotherapy is indicated for older patients, at risk for surgery or extensive tumors.
  • [MeSH-major] Ear Neoplasms / surgery. Glomus Jugulare Tumor / surgery. Glomus Tympanicum Tumor / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carotid Body Tumor / pathology. Carotid Body Tumor / surgery. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Radiotherapy, Adjuvant. Remission Induction. Retrospective Studies. Survival Rate

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  • (PMID = 16080641.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] France
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59. Cioffi JA, Yue WY, Mendolia-Loffredo S, Hansen KR, Wackym PA, Hansen MR: MicroRNA-21 overexpression contributes to vestibular schwannoma cell proliferation and survival. Otol Neurotol; 2010 Dec;31(9):1455-62
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  • [Title] MicroRNA-21 overexpression contributes to vestibular schwannoma cell proliferation and survival.
  • HYPOTHESIS: Elevated levels of hsa-microRNA-21 (miR-21) in vestibular schwannomas (VSs) may contribute to tumor growth by downregulating the tumor suppressor phosphatase and tensin homolog (PTEN) and consequent hyperactivation of protein kinase B (AKT), a key signaling protein in the cellular pathways that lead to tumor growth.
  • BACKGROUND: Vestibular schwannomas are benign tumors that arise from the vestibular nerve.
  • Left untreated, VSs can result in hearing loss, tinnitus, vestibular dysfunction, trigeminal nerve dysfunction, and can even become life threatening.
  • RESULTS: We found consistent overexpression of miR-21 when compared with normal vestibular nerve tissue.

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  • [Cites] Nat Clin Pract Oncol. 2008 Aug;5(8):487-91 [18560388.001]
  • [Cites] Cancer Res. 2008 Jul 1;68(13):5236-45 [18593924.001]
  • [Cites] Proteomics. 2009 Mar;9(5):1374-84 [19253296.001]
  • [Cites] Cardiovasc Res. 2009 Apr 1;82(1):21-9 [19147652.001]
  • [Cites] Neurobiol Dis. 2010 Jan;37(1):141-6 [19804833.001]
  • [Cites] Curr Med Chem. 2010;17(5):407-11 [20015039.001]
  • [Cites] Cell. 2000 Feb 18;100(4):387-90 [10693755.001]
  • [Cites] Neurochem Res. 2001 Jan;26(1):51-8 [11358282.001]
  • [Cites] Methods. 2001 Dec;25(4):402-8 [11846609.001]
  • [Cites] Hum Mol Genet. 2002 Dec 1;11(25):3179-89 [12444102.001]
  • [Cites] Trends Genet. 2004 Jan;20(1):23-32 [14698616.001]
  • [Cites] Cell. 2004 Jan 23;116(2):281-97 [14744438.001]
  • [Cites] Nature. 2004 Sep 16;431(7006):350-5 [15372042.001]
  • [Cites] Cell. 1993 Mar 12;72(5):791-800 [8453669.001]
  • [Cites] Nature. 1993 Jun 10;363(6429):515-21 [8379998.001]
  • [Cites] FASEB J. 1996 Dec;10(14):1578-88 [9002549.001]
  • [Cites] J Biol Chem. 1999 Jun 11;274(24):17209-18 [10358079.001]
  • [Cites] Nature. 2005 Jun 9;435(7043):834-8 [15944708.001]
  • [Cites] Cancer Res. 2005 Jul 15;65(14):6029-33 [16024602.001]
  • [Cites] Curr Opin Genet Dev. 2006 Feb;16(1):4-9 [16361094.001]
  • [Cites] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460.001]
  • [Cites] Glia. 2006 Apr 15;53(6):593-600 [16432850.001]
  • [Cites] Br J Cancer. 2006 Mar 27;94(6):776-80 [16495913.001]
  • [Cites] Life Sci. 2006 Oct 4;79(19):1773-80 [16815477.001]
  • [Cites] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945.001]
  • [Cites] Oncogene. 2007 Apr 26;26(19):2799-803 [17072344.001]
  • [Cites] J Neurosurg. 2007 May;106(5):866-71 [17542531.001]
  • [Cites] J Cell Biol. 2007 Jun 4;177(5):893-903 [17548515.001]
  • [Cites] Cell. 2007 Jun 29;129(7):1401-14 [17604727.001]
  • [Cites] Blood. 2007 Aug 15;110(4):1330-3 [17496199.001]
  • [Cites] Gastroenterology. 2007 Aug;133(2):647-58 [17681183.001]
  • [Cites] Curr Opin Otolaryngol Head Neck Surg. 2007 Oct;15(5):341-6 [17823551.001]
  • [Cites] J Biol Chem. 2008 Jan 11;283(2):1026-33 [17991735.001]
  • [Cites] Otol Neurotol. 2008 Jan;29(1):58-68 [18199958.001]
  • [Cites] Oncogene. 2008 Apr 3;27(15):2128-36 [17968323.001]
  • [Cites] Laryngoscope. 2008 Jun;118(6):1023-30 [18520822.001]
  • [Cites] J Neurochem. 2009 Feb;108(3):776-86 [19187095.001]
  • (PMID = 20856158.001).
  • [ISSN] 1537-4505
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC009801-03; United States / NIDCD NIH HHS / DC / K08DC006211; United States / NIDCD NIH HHS / DC / R01 DC002971; United States / NIDCD NIH HHS / DC / DC006211-05; United States / NIDCD NIH HHS / DC / K08 DC006211-05; United States / NIDCD NIH HHS / DC / R01DC02971; United States / NIDCD NIH HHS / DC / R01 DC009801; United States / NIDCD NIH HHS / DC / R01 DC009801-03; United States / NIDCD NIH HHS / DC / DC002971-14; United States / NIDCD NIH HHS / DC / R01 DC002971-14; United States / NIDCD NIH HHS / DC / K08 DC006211
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MIRN21 microRNA, human; 0 / MicroRNAs; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 3.1.3.48 / PTEN protein, human; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS237186; NLM/ PMC2978772
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60. Carrasco CA, Rojas-Salazar D, Chiorino R, Venega JC, Wohllk N: Melanotic nonpsammomatous trigeminal schwannoma as the first manifestation of Carney complex: case report. Neurosurgery; 2006 Dec;59(6):E1334-5; discussion E1335
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: Melanotic schwannoma is a rare neoplasm, classifiable as a peripheral nerve sheath tumor, and differentiated from a typical schwannoma by heavy pigmentation.
  • Half of patients with such "psammomatous melanotic schwannomas" have Carney complex, a dominantly transmitted autosomal disorder.
  • Most recently, the tumor suppressor gene, PRKAR1A, coding for the Type 1alpha regulatory subunit of protein kinase A was found to be mutated in approximately half of the known Carney complex families.
  • Although cranial schwannomas have been described in patients with Carney complex, their numbers are too small to be considered a definite part of the syndrome.
  • Magnetic resonance imaging scans of the brain revealed a small tumor with homogenous contrast in the right trigeminal pathway.
  • The lateral wall was opened between the cranial nerves, and a soft and black tumor was resected in a piecemeal fashion.
  • Histology and immunohistochemical analysis of the tumor were compatible with melanotic schwannoma, but no psammomatous bodies were identified.
  • We also postulate that the absence of psammoma bodies or cranial localization do not exclude this diagnosis.
  • [MeSH-major] Cranial Nerve Neoplasms / genetics. Cranial Nerve Neoplasms / pathology. Cyclic AMP-Dependent Protein Kinases / genetics. Endocrine Gland Neoplasms / genetics. Endocrine Gland Neoplasms / pathology. Neuroma, Acoustic / genetics. Neuroma, Acoustic / pathology. Trigeminal Ganglion / pathology

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  • (PMID = 17277668.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; 0 / PRKAR1A protein, human; EC 2.7.11.11 / Cyclic AMP-Dependent Protein Kinases
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61. Liscak R, Vladyka V, Urgosik D, Simonova G, Vymazal J: Repeated treatment of vestibular schwannomas after gamma knife radiosurgery. Acta Neurochir (Wien); 2009 Apr;151(4):317-24; discussion 324
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeated treatment of vestibular schwannomas after gamma knife radiosurgery.
  • PURPOSE: When gamma knife radiosurgery (GKS) does not achieve control of the growth of a tumour, the need to repeat treatment is considered.
  • The results and risks of repeat treatment of patients with a vestibular schwannoma were reviewed to assess its efficacy and safety.
  • METHODS: Between 1992 and 2001, we treated 351 patients with a vestibular schwannoma by GKS, control of the growth of the tumour was not achieved in 32.
  • 26 patients underwntrepeat GKS and five patients had an open microsurgical operation and one stereotactic aspiration of a tumour cyst.
  • 15 tumours became smaller, seven remained unchanged and two enlarged.
  • An operation to radically resect the tumour was performed in five patients after the first GKS and for a subtotal removal in one after repeated GKS.
  • CONCLUSIONS: In the small proportion of patients (9%) in whom initial GKS does not control the growth of a vestibular schwannoma, most can be controlled by further GKS with a very low risk of a complications.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Postoperative Complications / epidemiology. Radiosurgery / adverse effects. Radiosurgery / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Facial Nerve Injuries / epidemiology. Female. Hearing Loss, Sensorineural / epidemiology. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neoplasm Recurrence, Local / surgery. Neurosurgical Procedures / statistics & numerical data. Reoperation / adverse effects. Reoperation / statistics & numerical data. Risk Assessment. Vestibular Nerve / pathology. Vestibular Nerve / surgery. Young Adult

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  • (PMID = 19277457.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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62. Pollock BE, Link MJ: Vestibular schwannoma radiosurgery after previous surgical resection or stereotactic radiosurgery. Prog Neurol Surg; 2008;21:163-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vestibular schwannoma radiosurgery after previous surgical resection or stereotactic radiosurgery.
  • OBJECTIVE: To evaluate radiosurgery outcomes in vestibular schwannoma (VS) patients who have undergone prior tumor treatment.
  • METHODS: Retrospective review of 55 consecutive VS patients having radiosurgery for recurrent (n = 22) or residual tumors (n = 33) after prior microsurgery.
  • Forty-seven patients (84%) had enlarging tumors at the time of radiosurgery.
  • The median tumor volume was 3.0 cm3 (range, 0.1-18.1).
  • The median tumor margin dose was 14 Gy (range, 12-20).
  • The tumor control rate was 94%.
  • Four of 42 patients (10%) with normal to moderate facial nerve function before radiosurgery developed facial weakness.
  • Three of these 4 patients received a tumor margin dose of 20 Gy.
  • Staged treatment involving subtotal tumor removal and radiosurgery is an option for patients with large VSs to facilitate both cranial nerve preservation and long-term tumor control.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adolescent. Adult. Aged. Cohort Studies. Female. Humans. Male. Middle Aged. Neoplasm, Residual. Radiation Dosage. Reoperation. Retrospective Studies. Treatment Failure. Tumor Burden. Young Adult

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  • (PMID = 18810215.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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63. de Ipolyi AR, Yang I, Buckley A, Barbaro NM, Cheung SW, Parsa AT: Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report. Neurosurgery; 2008 May;62(5):E1164-5; discussion E1165
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report.
  • OBJECTIVE: A vestibular schwannoma (VS) is a benign tumor of the VIIIth cranial nerve that can often be treated by microsurgery or radiosurgery and demonstrates high tumor control rates.
  • INTERVENTION: After GKS with a 12-Gy dose to the 50% isodose line, the tumor expanded transiently to 3.2 cm and then regressed to 1.0 cm over the next 2 years.
  • After microsurgical tumor excision, the patient's symptoms abated.
  • The mechanisms responsible for radiation-induced cystic tumor expansion have not been thoroughly elucidated.
  • The risk of unpredictable tumor enlargement should be discussed with patients when considering GKS for cystic tumors.
  • [MeSH-major] Neoplasm Recurrence, Local / surgery. Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Aged. Breast Neoplasms / pathology. Cysts / pathology. Cysts / surgery. Female. Hearing Loss / etiology. Humans. Hyperthyroidism / pathology. Magnetic Resonance Imaging. Microsurgery. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery

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  • (PMID = 18580785.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Tringali S, Dubreuil C, Zaouche S, Ferber-Viart C: Are stage IV vestibular schwannomas preoperatively different from other stages? Otol Neurotol; 2008 Jan;29(1):46-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Are stage IV vestibular schwannomas preoperatively different from other stages?
  • OBJECTIVE: The aim of this study was to focus on the clinical and paraclinical symptoms of patients suffering from Stage IV vestibular schwannomas (VSs).
  • MAIN OUTCOME MEASURES: Patients were classified as having Stage I, II, III, or IV tumors according to Tos criteria as evaluated by magnetic resonance imaging.
  • PREOPERATIVE CLINICAL EVALUATION: We recorded the occurrence of complaints (%) and duration (yr) of hearing loss, tinnitus, and balance disorder.
  • Preoperative paraclinical evaluation included pure-tone (PTA) and speech audiometry, auditory brainstem response (ABR) patterns, and vestibular deficit at videonystamography (VNG).
  • The durations of hearing loss, tinnitus, and balance disorders were similar whatever the tumor stage.
  • In contrast, the occurrence of balance disorder was higher in Stage IV compared with all other stages.
  • Occurrence of clinical symptoms, ABR, and VNG pattern can be explained by the fact that Stage IV develops rapidly in the vestibular, rather than the cochlear nerve and by the fact that larger tumors can be cerebellar compression.
  • [MeSH-major] Ear Neoplasms / pathology. Neuroma, Acoustic / pathology. Otologic Surgical Procedures
  • [MeSH-minor] Audiometry, Pure-Tone. Caloric Tests. Evoked Potentials, Auditory, Brain Stem / physiology. Female. Hearing Loss / diagnosis. Hearing Loss / etiology. Humans. Male. Middle Aged. Neoplasm Staging. Speech Perception / physiology. Tinnitus / diagnosis. Tinnitus / etiology. Vertigo / etiology. Vertigo / physiopathology. Vestibular Function Tests

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  • (PMID = 18046259.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Benech F, Perez R, Fontanella MM, Morra B, Albera R, Ducati A: Cystic versus solid vestibular schwannomas: a series of 80 grade III-IV patients. Neurosurg Rev; 2005 Jul;28(3):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cystic versus solid vestibular schwannomas: a series of 80 grade III-IV patients.
  • Cystic acoustic neuromas are less frequent than solid ones and present different clinical and radiological features.
  • This study was designed to compare surgical results and complications of solid and cystic vestibular schwannomas of matching size operated upon via either a retrosygmoid or a translabyrinthine approach.
  • The study included 80 patients presenting with grade III and IV acoustic vestibular schwannomas referred to the Neurosurgical and ENT team in the Department of Neuroscience of Torino, Italy.
  • Twenty-six were cystic and 54 were solid tumours.
  • In cystic tumors, rapid clinical worsening is common, due to sudden expansion of cystic elements.
  • Tighter adherences are found between cystic tumours and nervous elements (particularly brainstem and possibly facial nerve), once compared to solid ones.
  • Operative morbidity appears to be higher in cystic tumours.
  • A wait and see policy should not to be applied to patients with cystic tumours.
  • Careful technique, possibly sharp dissection, to divide the tumour adherences from the nervous tissue must be employed, in order to avoid lesions on brainstem veins and traction on a thin facial nerve.
  • [MeSH-major] Acromegaly / etiology. Acromegaly / therapy. Adenoma / surgery. Human Growth Hormone / metabolism. Neurosurgical Procedures / methods. Pituitary Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Connective Tissue / pathology. Connective Tissue / surgery. Female. Humans. Immunohistochemistry. Male. Microsurgery. Middle Aged. Neoplasm Recurrence, Local. Pituitary Hormones / deficiency

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  • [Cites] AJNR Am J Neuroradiol. 1993 Sep-Oct;14(5):1241-7 [8237710.001]
  • [Cites] J Clin Neurosci. 2002 Jul;9(4):453-5 [12217679.001]
  • [Cites] Acta Neurochir (Wien). 1991;110(3-4):120-3 [1927602.001]
  • [Cites] Neurosurgery. 1997 Mar;40(3):469-81; discussion 481-2 [9055285.001]
  • [Cites] Virchows Arch A Pathol Anat Histopathol. 1992;420(1):59-64 [1539452.001]
  • [Cites] Stereotact Funct Neurosurg. 1996;66 Suppl 1:103-11 [9032850.001]
  • [Cites] J Formos Med Assoc. 1995 Aug;94(8):487-93 [7549578.001]
  • [Cites] Acta Neurochir (Wien). 1999;141(12):1281-5; discussion 1285-6 [10672298.001]
  • [Cites] J Laryngol Otol. 2000 Dec;114(12):935-9 [11177361.001]
  • [Cites] Arch Otolaryngol Head Neck Surg. 1994 Dec;120(12):1333-8 [7980897.001]
  • [Cites] Acta Otolaryngol Suppl. 1997;530:1-27 [9288227.001]
  • [Cites] Neurosurgery. 1997 Jan;40(1):11-21; discussion 21-3 [8971819.001]
  • [Cites] Can Assoc Radiol J. 1993 Dec;44(6):453-9 [8252428.001]
  • [Cites] Acta Neurochir (Wien). 1996;138(6):695-9 [8836284.001]
  • [Cites] Laryngoscope. 1994 Nov;104(11 Pt 1):1348-52 [7968163.001]
  • [Cites] Otolaryngol Head Neck Surg. 1985 Apr;93(2):146-7 [3921901.001]
  • [Cites] J Laryngol Otol. 1994 May;108(5):375-9 [8035113.001]
  • [Cites] Neuroradiology. 1986;28(3):208-14 [3725009.001]
  • [Cites] Acta Otolaryngol. 1993 Jul;113(4):519-23 [8379308.001]
  • (PMID = 15739069.001).
  • [ISSN] 0344-5607
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Pituitary Hormones; 12629-01-5 / Human Growth Hormone
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66. Lunsford LD, Niranjan A, Flickinger JC, Maitz A, Kondziolka D: Radiosurgery of vestibular schwannomas: summary of experience in 829 cases. J Neurosurg; 2005 Jan;102 Suppl:195-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radiosurgery of vestibular schwannomas: summary of experience in 829 cases.
  • OBJECT: Management options for vestibular schwannomas (VSs) have greatly expanded since the introduction of stereotactic radiosurgery.
  • Optimal outcomes reflect long-term tumor control, preservation of cranial nerve function, and retention of quality of life.
  • The average tumor volume was 2.5 cm3.
  • The median margin dose to the tumor was 13 Gy (range 10-20 Gy).
  • Unchanged hearing preservation was possible in 50 to 77% of patients (up to 90% in those with intracanalicular tumors).
  • Trigeminal symptoms were detected in less than 3% of patients whose tumors reached the level of the trigeminal nerve.
  • Tumor control rates at 10 years were 97% (no additional treatment needed).
  • Gamma knife surgery provides a low risk, minimally invasive treatment option for patients with newly diagnosed or residual vs. Cranial nerve preservation and quality of life maintenance are possible in long-term follow up.
  • [MeSH-major] Neuroma, Acoustic / surgery. Radiosurgery / instrumentation
  • [MeSH-minor] Female. Follow-Up Studies. Hearing Disorders / diagnosis. Hearing Disorders / etiology. Humans. Magnetic Resonance Imaging. Male. Neoplasm Staging. Radiation Dosage. Severity of Illness Index. Trigeminal Neuralgia / etiology. Tumor Burden / radiation effects

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  • (PMID = 15662809.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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67. Fuentes S, Arkha Y, Pech-Gourg G, Grisoli F, Dufour H, Régis J: Management of large vestibular schwannomas by combined surgical resection and gamma knife radiosurgery. Prog Neurol Surg; 2008;21:79-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of large vestibular schwannomas by combined surgical resection and gamma knife radiosurgery.
  • In this report, we evaluated the treatment results of a combination of surgery and radiosurgery for large vestibular schwannomas.
  • The average maximum diameter of the tumor was 40 (35-45) mm.
  • The mean peripheral dose administered was 11.8 (range 11-13) Gy, and the mean dose administered in the centre of the tumor was 23.75 (22-26) Gy.
  • Excellent facial nerve function (House-Brackmann grade 1 or 2) was preserved in 7/8 patients (87.5%).
  • In the case of large vestibular schwannomas, the combined management is one option for maintaining cranial nerve function and tumor growth control.
  • [MeSH-major] Neuroma, Acoustic / pathology. Neuroma, Acoustic / surgery. Radiosurgery
  • [MeSH-minor] Adult. Aged. Cohort Studies. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm, Residual. Radiotherapy Dosage. Retrospective Studies. Treatment Outcome

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  • (PMID = 18810202.001).
  • [ISSN] 0079-6492
  • [Journal-full-title] Progress in neurological surgery
  • [ISO-abbreviation] Prog Neurol Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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68. Tew JM Jr: Supplementary comment on "optimal extent of resection in vestibular schwannoma surgery: relationship to recurrence and facial nerve preservation". Neurol Med Chir (Tokyo); 2006 Jun;46(6):318
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Supplementary comment on "optimal extent of resection in vestibular schwannoma surgery: relationship to recurrence and facial nerve preservation".
  • [MeSH-major] Neoplasm Recurrence, Local / diagnosis. Neoplasm, Residual / diagnosis. Neuroma, Acoustic / surgery. Postoperative Complications / diagnosis

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  • [CommentOn] Neurol Med Chir (Tokyo). 2006 Apr;46(4):176-80; discussion 180-1 [16636507.001]
  • (PMID = 16794356.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] Japan
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