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1. Arias-Santiago S, Aneiros-Fernandez J, Buendía-Eisman A, Girón-Prieto MS, Aneiros-Cachaza J: A 5-year-old boy with comedo-like lesions on the right buttock. Dermatol Online J; 2010;16(10):11
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  • [Title] A 5-year-old boy with comedo-like lesions on the right buttock.
  • Histopathological exam revealed multiple atrophic cystically dilated hair follicles containing abundant keratinous debris and small projections of epithelial cells extending from the wall of the cyst into the surrounding dermis, compatible with nevus comedonicus.
  • [MeSH-major] Buttocks / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 21062605.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. Melnik BC, Schmitz G, Zouboulis CC: Anti-acne agents attenuate FGFR2 signal transduction in acne. J Invest Dermatol; 2009 Aug;129(8):1868-77
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  • [Title] Anti-acne agents attenuate FGFR2 signal transduction in acne.
  • Increased fibroblast growth factor receptor-2 (FGFR2) signaling has been proposed to be involved in acne pathogenesis and explains acne lesions in Apert syndrome and unilateral acneiform nevus associated with gain-of-function point mutations of FGFR2.
  • If, indeed, increased FGFR2 signaling plays a major pathogenic role in follicular hyperkeratinization and sebaceous gland hypertrophy in acne, effective anti-acne drugs may attenuate increased FGFR2 signaling.
  • The purpose of this article is to elucidate the hypothesis that known anti-acne agents may operate by downregulation of increased FGFR2 signaling.
  • The gain-of-function mutations of FGFR2 in Apert syndrome and unilateral acneiform nevus, and the proposed synergistic inhibitory interactions of anti-acne agents at various levels of the FGFR2-signaling cascade underline the role of FGFR2 signaling in the pathogenesis of acne.
  • [MeSH-major] Acne Vulgaris / drug therapy. Receptor, ErbB-2 / antagonists & inhibitors. Signal Transduction / drug effects


3. Melnik BC: Role of FGFR2-signaling in the pathogenesis of acne. Dermatoendocrinol; 2009 May;1(3):141-56
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  • [Title] Role of FGFR2-signaling in the pathogenesis of acne.
  • It is the purpose of this review to extend our understanding of the fibroblast growth factor (FGF) receptor-2b-signaling network in the pathogenesis of acne.
  • A new concept of the role of FGFR2b-signaling in dermal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis, sebaceous gland proliferation and lipogenesis is presented.
  • The FGFR2-gain-of-function mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases pointing the way to androgen-dependent dermalepithelial FGFR2-signaling in acne.
  • Androgen-mediated upregulation of FGFR2b-signaling in acne-prone skin appears to be involved in the pathogenesis of acne vulgaris.
  • Postnatal deletion of FGFR2b in mice resulted in severe sebaceous gland atrophy.
  • The importance of FGFR2b in sebaceous gland physiology is further supported by the mode of action of anti-acne agents which have been proposed to attenuate FGFR2b-signaling.
  • Downregulation of FGFR2b-signaling by isotretinoin explains its therapeutic effect in acne.
  • Insulin-like growth factor-1 (IGF-1), the mediator of growth hormone during puberty, intracts with androgen-dependent FGFR2b-signaling and links androgen- and FGF-mediated signal transduction important in sebaceous gland homeostasis.
  • The search for a follicular defect in the dermalepithelial regulation of growth factor-signaling in acne-prone skin appears to be a most promising approach to clarify the pathogenesis of acne.

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 20436882.001).
  • [ISSN] 1938-1980
  • [Journal-full-title] Dermato-endocrinology
  • [ISO-abbreviation] Dermatoendocrinol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2835907
  • [Keywords] NOTNLM ; Apert syndrome / acne / comedogenesis / fibroblast growth factor receptor-2 / fibroblast growth factors / insulin / insulin-like growth factor-1 / interleukin-1α / nevus comedonicus / sebogenesis / unilateral acneiform nevus
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4. Asokan N, Sridevi PK: Inflammatory nevus comedonicus in an infant. Indian J Dermatol Venereol Leprol; 2008 Nov-Dec;74(6):658-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inflammatory nevus comedonicus in an infant.
  • [MeSH-major] Nevus / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19172001.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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5. El Ghelbazouri N, Ismaili N, Ahrich N, Benarafa A, Senouci K, Mansouri F, Hassam B: [Nevus comedonicus syndrome]. Ann Dermatol Venereol; 2007 Aug-Sep;134(8-9):663-6
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  • [Title] [Nevus comedonicus syndrome].
  • BACKGROUND: Nevus comedonicus is a rare disease and diagnosis is made chiefly on clinical grounds.
  • It may occur in isolation, or in rare cases, it may be combined with other congenital malformations to constitute nevus comedonicus syndrome.
  • Clinical diagnosis of nevus comedonicus was confirmed by histological examination of the skin.
  • DISCUSSION: Nevus comedonicus is one of the rarest forms of cutaneous nevus.
  • This case is original as regards the extent and topography of the nevus covering the left side of the patient's body and its association with congenital cataract potentially indicating nevus comedonicus syndrome.
  • This syndrome is extremely rare and belongs to a large group of epidermal nevus syndromes characterised by association of nevus and extracutaneous malformations, particularly ocular, skeletal and neurological.
  • [MeSH-major] Nevus / congenital. Skin Neoplasms / congenital

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  • (PMID = 17925691.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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6. Kurokawa I, Nakai Y, Nishimura K, Hakamada A, Isoda K, Yamanaka K, Mizutani H, Tsubura A: Cytokeratin and filaggrin expression in nevus comedonicus. J Cutan Pathol; 2007 Apr;34(4):338-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytokeratin and filaggrin expression in nevus comedonicus.
  • To elucidate the pathogenesis of abnormal keratinization in nevus comedonicus, we performed an immunohistochemical study using antikeratin and antifilaggrin (filament-aggregating protein) antibodies.
  • There were no significant differences between nevus comedonicus and normal skin in cytokeratin expression.
  • The disorder of terminal differentiation related to filaggrin may play a role in the pathogenesis of abnormal keratinization in nevus comedonicus.
  • [MeSH-major] Hair Follicle / pathology. Intermediate Filament Proteins / biosynthesis. Keratins / biosynthesis. Sebaceous Gland Diseases / pathology

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  • (PMID = 17381805.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Intermediate Filament Proteins; 0 / filaggrin; 68238-35-7 / Keratins
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7. Ghaninezhad H, Ehsani AH, Mansoori P, Taheri A: Naevus comedonicus of the scalp. J Eur Acad Dermatol Venereol; 2006 Feb;20(2):184-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Naevus comedonicus of the scalp.
  • We report the case of a 3-year-old boy with naevus comedonicus, characterized by confluent clusters of dilated follicular orifices plugged with keratinous material that resemble open comedones, located on the scalp.
  • [MeSH-major] Folliculitis / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 16441628.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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8. Sardana K, Garg VK: Successful treatment of nevus comedonicus with ultrapulse CO2 laser. Indian J Dermatol Venereol Leprol; 2009 Sep-Oct;75(5):534-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of nevus comedonicus with ultrapulse CO2 laser.
  • [MeSH-major] Lasers, Gas / therapeutic use. Nevus / surgery. Skin Neoplasms / surgery

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  • (PMID = 19736453.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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9. Guldbakke KK, Khachemoune A, Deng A, Sina B: Naevus comedonicus: a spectrum of body involvement. Clin Exp Dermatol; 2007 Sep;32(5):488-92
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Naevus comedonicus: a spectrum of body involvement.
  • Naevus comedonicus (NC) is a rare developmental anomaly, with < 200 cases reported in the literature.
  • It usually occurs on the face, neck or chest, appearing as groups of closely arranged dilated follicular openings with keratin plugs.
  • [MeSH-major] Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 17509056.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents; 0 / Dermatologic Agents
  • [Number-of-references] 34
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10. Dufour DN, Bryld LE, Jemec GB: Hidradenitis suppurativa complicating naevus comedonicus: the possible influence of mechanical stress on the development of hidradenitis suppurativa. Dermatology; 2010;220(4):323-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hidradenitis suppurativa complicating naevus comedonicus: the possible influence of mechanical stress on the development of hidradenitis suppurativa.
  • Naevus comedonicus is a rare, benign hamartoma consisting of grouped abnormal hair follicles and, occasionally, associated with other diseases.
  • We describe an infant who developed hidradenitis-like lesions in an inguinal naevus comedonicus following increased mechanical stress on the region.

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  • [Copyright] Copyright (c) 2010 S. Karger AG, Basel.
  • (PMID = 20389029.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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11. Kaliyadan F, Nampoothiri S, Sunitha V, Kuruvilla VE: Nevus comedonicus syndrome--nevus comedonicus associated with ipsilateral polysyndactyly and bilateral oligodontia. Pediatr Dermatol; 2010 Jul-Aug;27(4):377-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus comedonicus syndrome--nevus comedonicus associated with ipsilateral polysyndactyly and bilateral oligodontia.
  • A 7-year-old boy diagnosed as a case of nevus comedonicus syndrome is presented because of the rarity of the condition and the association of the previously unreported features oligodontia and unilateral polysyndactyly restricted to the same side as the nevus comedonicus.
  • [MeSH-major] Anodontia / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis. Syndactyly / diagnosis


12. Melnik B, Schmitz G: FGFR2 signaling and the pathogenesis of acne. J Dtsch Dermatol Ges; 2008 Sep;6(9):721-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FGFR2 signaling and the pathogenesis of acne.
  • Acne in Apert syndrome and unilateral segmental acneiform nevus are associated with mutations of fibroblast growth factor receptor 2 (FGFR2), which are likely to be involved in the pathogenesis of acne.
  • Translational animal and cellular models, developmental biology studies and clinical observations have contributed to our understanding of FGF-FGFR2 signaling in the pilosebaceous follicle.
  • The importance of FGF-FGFR2 signaling in mesenchymal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis and sebaceous gland proliferation is explored.
  • Overstimulation of FGFR2 signaling with increased expression of interleukin-1alpha explains acne in Apert syndrome und nevus comedonicus.
  • Androgen-mediated up-regulation of FGFR2 signaling could be the initiating signal in the pathogenesis of acne.
  • The gain of function FGFR2 mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases for uncovering the fundamental process of androgen-dependent mesenchymal-epithelial FGF-FGFR2 signaling in acne in Apert syndrome, nevus comedonicus and acne vulgaris.
  • [MeSH-major] Acne Vulgaris / metabolism. Acrocephalosyndactylia / metabolism. Fibroblast Growth Factors / metabolism. Receptors, Fibroblast Growth Factor / metabolism. Signal Transduction. Skin / metabolism

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  • (PMID = 19000061.001).
  • [ISSN] 1610-0387
  • [Journal-full-title] Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • [ISO-abbreviation] J Dtsch Dermatol Ges
  • [Language] eng; ger
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Receptors, Fibroblast Growth Factor; 62031-54-3 / Fibroblast Growth Factors
  • [Number-of-references] 50
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13. Tantcheva-Poor I, Reinhold K, Krieg T, Happle R: Trichilemmal cyst nevus: a new complex organoid epidermal nevus. J Am Acad Dermatol; 2007 Nov;57(5 Suppl):S72-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trichilemmal cyst nevus: a new complex organoid epidermal nevus.
  • A 31-year-old woman had an organoid nevus characterized by multiple trichilemmal cysts arranged in a bandlike pattern.
  • The involved streaks followed Blaschko's lines and were covered, in addition, by multiple filiform hyperkeratoses and comedo-like plugs.
  • Some histopathologic features of this complex nevus were reminiscent of those of well-established organoid nevi such as nevus comedonicus, porokeratotic eccrine nevus, or hair follicle nevus, but the presence of multiple large trichilemmal cysts was a conspicuously distinctive abnormality.
  • Consequently, we propose for this new organoid nevus the names "trichilemmal cyst nevus" or "nevus trichilemmocysticus. "
  • [MeSH-major] Epidermal Cyst / pathology. Epidermis. Facial Neoplasms / pathology. Nevus / pathology. Shoulder. Skin Neoplasms / pathology. Thigh


14. Happle R: The group of epidermal nevus syndromes Part II. Less well defined phenotypes. J Am Acad Dermatol; 2010 Jul;63(1):25-30; quiz 31-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The group of epidermal nevus syndromes Part II. Less well defined phenotypes.
  • In addition to the well established epidermal nevus syndromes, such as Schimmelpenning, Becker, Proteus, CHILD, or nevus comedonicus syndromes, the group of less well defined phenotypes associated with epidermal nevi presently includes nevus trichilemmocysticus syndrome, didymosis aplasticosebacea, SCALP syndrome (sebaceous nevus, central nervous system malformations, aplasia cutis congenita, limbal dermoid,and pigmented nevus), Gobello syndrome, Bäfverstedt syndrome, NEVADA syndrome (nevus epidermicus verrucosus with angio-dysplasia and aneurysms), and CLOVE syndrome (congenital lipomatous overgrowth, vascular malformations, and epidermal nevus).
  • Future clinical and molecular research may show which of these disorders can be added to the list of well defined nosologic entities.
  • LEARNING OBJECTIVES: After completing this learning activity, participants should be able to understand why the list of distinct epidermal nevus syndromes can thus far not be regarded as being complete; why clinicians, when seeing a patient with an epidermal nevus syndrome that is difficult to categorize, should bear in mind the group of less well defined epidermal nevus syndromes; and how practical dermatologists can help recognize rare forms of epidermal nevus syndromes and categorize them appropriately.
  • [MeSH-major] Nevus. Skin Neoplasms

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  • [Copyright] Copyright (c) 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20542175.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Ambay AR, Stratman EJ: Paintball: dermatologic injuries. Cutis; 2007 Jul;80(1):49-50
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We report distinctive follicular stippling and annular scars resulting from paintball injuries in 2 males.
  • Dermatologists may encounter paintball-related injuries during routinely scheduled visits for acne or nevi surveillance.

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  • (PMID = 17725065.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Sugarman JL: Epidermal nevus syndromes. Semin Cutan Med Surg; 2007 Dec;26(4):221-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal nevus syndromes.
  • The term "epidermal nevus syndrome" (ENS) has been used to describe the association of epidermal hamartomas and extra-cutaneous abnormalities.
  • Epidermal nevi follow the lines of Blaschko.
  • Several subsets with characteristic features have been delineated including the nevus sebaceous syndrome, Proteus syndrome, CHILD syndrome, Becker nevus syndrome, nevus comedonicus syndrome, and phakomatosis pigmentokeratotica.
  • Epidermal nevi have been associated with benign and malignant neoplasms.
  • [MeSH-major] Hamartoma. Nevus
  • [MeSH-minor] Humans. Keratinocytes / pathology. Mosaicism. Mutation. Nevus, Pigmented / diagnosis. Nevus, Sebaceous of Jadassohn / classification. Nevus, Sebaceous of Jadassohn / diagnosis. Nevus, Sebaceous of Jadassohn / epidemiology. Proteus Syndrome. Skin Neoplasms / epidemiology. Syndrome. Terminology as Topic

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  • (PMID = 18395670.001).
  • [ISSN] 1085-5629
  • [Journal-full-title] Seminars in cutaneous medicine and surgery
  • [ISO-abbreviation] Semin Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 87
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17. Happle R: The group of epidermal nevus syndromes Part I. Well defined phenotypes. J Am Acad Dermatol; 2010 Jul;63(1):1-22; quiz 23-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The group of epidermal nevus syndromes Part I. Well defined phenotypes.
  • The epidermal nevus syndromes represent a group of distinct disorders that can be distinguished by the type of associated epidermal nevus and by the criterion of presence or absence of heritability.
  • Well defined syndromes characterized by organoid epidermal nevi include Schimmelpenning syndrome, phacomatosis pigmentokeratotica, nevus comedonicus syndrome, angora hair nevus syndrome, and Becker nevus syndrome.
  • The molecular basis of these disorders has so far not been identified.
  • By contrast, the group of syndromes characterized by keratinocytic nevi comprises three phenotypes with a known molecular etiology in the form of CHILD (congenital hemidysplasia with ichthyosiform nevus and limb defects) syndrome, type 2 segmental Cowden disease, and fibroblast growth factor receptor 3 epidermal nevus syndrome (García-Hafner-Happle syndrome), whereas Proteus syndrome is still of unknown origin.
  • From this overview, it is clear that a specific type of these disorders cannot be classified by the name "epidermal nevus syndrome" nor by the terms "organoid nevus syndrome" or "keratinocytic nevus syndrome."
  • LEARNING OBJECTIVES: After completing this learning activity, participants should be able to distinguish nine different epidermal nevus syndromes by their characteristic features, understand the practical significance of avoiding terms like "epidermal nevus syndrome" or "keratinocytic nevus syndrome" to define any specific entity within this group of disorders, and differentiate between nonhereditary traits and those bearing a genetic risk because of either Mendelian or non-Mendelian inheritance.
  • [MeSH-major] Nevus. Skin Neoplasms
  • [MeSH-minor] Child. Child, Preschool. Female. Hamartoma Syndrome, Multiple. Humans. Infant. Infant, Newborn. Male. Neurocutaneous Syndromes. Nevus, Sebaceous of Jadassohn. Phenotype. Proteus Syndrome. Syndrome


18. Pelivani N, Houriet C, Haneke E: Trichilemmal cyst nevus with a sebaceous nevus component. Dermatology; 2010;221(4):289-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Trichilemmal cyst nevus with a sebaceous nevus component.
  • A 23-year-old man with a typical trichilemmal cyst nevus is reported.
  • This recently described disorder is sufficiently characteristic to differentiate it from sebaceous nevus, nevus comedonicus, porokeratotic eccrine nevus, nevus corniculatus, follicular basaloid hamartoma, Munro's nevus and Gardner's syndrome.
  • [MeSH-major] Epidermal Cyst / diagnosis. Facial Neoplasms / diagnosis. Nevus / diagnosis. Skin Neoplasms / diagnosis. Sweat Gland Neoplasms / diagnosis

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  • [Copyright] Copyright © 2010 S. Karger AG, Basel.
  • (PMID = 20720396.001).
  • [ISSN] 1421-9832
  • [Journal-full-title] Dermatology (Basel, Switzerland)
  • [ISO-abbreviation] Dermatology (Basel)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Dermatologic Agents; EH28UP18IF / Isotretinoin
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19. Demerdjieva Z, Kavaklieva S, Tsankov N: Epidermal nevus syndrome and didymosis aplasticosebacea. Pediatr Dermatol; 2007 Sep-Oct;24(5):514-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal nevus syndrome and didymosis aplasticosebacea.
  • The epidermal nevus syndrome is a disease complex consisting of the association of an epidermal nevus with various developmental abnormalities of the skin, eyes, nervous, skeletal, cardiovascular, and urogenital systems.
  • The epidermal nevi are classified according to their predominant component; nevus sebaceus (sebaceous glands), nevus comedonicus (hair follicles), and nevus verrucosus (keratinocytes).
  • We report a neonate who presented with a nevus sebaceus on the scalp and face as well as a coloboma and dermoid on his left eye.
  • Within the sebaceous nevus on the scalp, circumscribed lesions of aplasia cutis congenita were detected, which is consistent with the recently proposed term in the literature didymosis aplasticosebacea.
  • [MeSH-major] Ectodermal Dysplasia / pathology. Hamartoma / pathology. Nevus / pathology


20. Brandling-Bennett HA, Morel KD: Epidermal nevi. Pediatr Clin North Am; 2010 Oct;57(5):1177-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal nevi.
  • Nevi or nests of cells may be made up of a variety of cell types.
  • The cell types that live in the epidermis include epidermal cells or keratinocytes, sebaceous glands, hair follicles, apocrine and eccrine glands, and smooth muscle cells.
  • This article discusses epidermal or keratinocyte nevi, nevus sebaceous, nevus comedonicus, smooth muscle hamartomas, and inflammatory linear verrucous epidermal nevi.
  • Syndromes associated with epidermal nevi are also reviewed.
  • [MeSH-major] Nevus, Pigmented / classification. Nevus, Pigmented / diagnosis. Skin Neoplasms / classification. Skin Neoplasms / diagnosis
  • [MeSH-minor] Abnormalities, Multiple / classification. Abnormalities, Multiple / diagnosis. Ectodermal Dysplasia / classification. Ectodermal Dysplasia / diagnosis. Hamartoma / classification. Hamartoma / diagnosis. Humans. Infant Welfare. Infant, Newborn. Neurocutaneous Syndromes / classification. Neurocutaneous Syndromes / diagnosis. Nevus / classification. Nevus / diagnosis. Nevus, Sebaceous of Jadassohn / classification. Nevus, Sebaceous of Jadassohn / diagnosis

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20888465.001).
  • [ISSN] 1557-8240
  • [Journal-full-title] Pediatric clinics of North America
  • [ISO-abbreviation] Pediatr. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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21. Finn LS, Argenyi ZB: Congenital panfollicular nevus: report of a new entity. J Cutan Pathol; 2005 Jan;32(1):59-62
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Congenital panfollicular nevus: report of a new entity.
  • The various forms of non-melanocytic nevi (hamartomas) are usually encountered in pediatric patients, and nevus sebaceous of Jadassohn is the most common to have undifferentiated pilosebaceous units.
  • We report a unique congenital follicular nevus that fails to meet the criteria of any previously described follicular neoplasm, despite the plethora of alternatives.
  • Clinically considered a syringocystadenoma papilliferum, the excised lesion contained multiple dermal nodules that exhibited nearly all stages of follicular differentiation.
  • The periodicity of the follicular proliferations was akin to normal terminal hair, and a prominent perifollicular sheath surrounded each.
  • [MeSH-major] Hair Diseases / congenital. Hamartoma / congenital. Nevus / congenital. Skin Neoplasms / congenital


22. Melnik BC, Vakilzadeh F, Aslanidis C, Schmitz G: Unilateral segmental acneiform naevus: a model disorder towards understanding fibroblast growth factor receptor 2 function in acne? Br J Dermatol; 2008 Jun;158(6):1397-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Unilateral segmental acneiform naevus: a model disorder towards understanding fibroblast growth factor receptor 2 function in acne?
  • [MeSH-major] Acne Vulgaris / genetics. Receptor, Fibroblast Growth Factor, Type 2 / genetics. Receptors, Interleukin-1 / metabolism. Skin Neoplasms / genetics
  • [MeSH-minor] Adolescent. Cell Proliferation. Epithelial Cells. Humans. Male. Nevus / genetics. Nevus / pathology

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  • (PMID = 18410418.001).
  • [ISSN] 1365-2133
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Interleukin-1; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 2
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23. Morillo V, Manrique P, De Miguel E, Arechalde A, Mariscal A: Nevus comedonicus with epidermolytic hyperkeratosis. Eur J Dermatol; 2007 Mar-Apr;17(2):176-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus comedonicus with epidermolytic hyperkeratosis.
  • [MeSH-major] Hyperkeratosis, Epidermolytic / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 17337416.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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24. Ahn SY, Oh Y, Bak H, Ahn SK: Co-occurrence of nevus comedonicus with accessory breast tissue. Int J Dermatol; 2008 May;47(5):530-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Co-occurrence of nevus comedonicus with accessory breast tissue.
  • [MeSH-major] Breast. Choristoma / complications. Nevus / complications. Skin / pathology. Skin Neoplasms / complications

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  • (PMID = 18412880.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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25. Caers SJ, Van der Geer S, Beverdam EG, Krekels GA, Ostertag JU: Successful treatment of nevus comedonicus with the use of the Erbium Yag laser. J Eur Acad Dermatol Venereol; 2008 Mar;22(3):375-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of nevus comedonicus with the use of the Erbium Yag laser.

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  • (PMID = 18005024.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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26. Walling HW, Swick BL: Squamous cell carcinoma arising in nevus comedonicus. Dermatol Surg; 2009 Jan;35(1):144-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Squamous cell carcinoma arising in nevus comedonicus.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Facial Neoplasms / pathology. Neoplasms, Second Primary / pathology. Nevus / pathology. Skin Neoplasms / pathology


27. Wang CY, Chen WC, Cheng YW: Bilateral circumscribed epidermal naevi or naevoid hyperkeratosis of areola superimposed with naevus comedonicus? J Eur Acad Dermatol Venereol; 2006 Oct;20(9):1152-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Bilateral circumscribed epidermal naevi or naevoid hyperkeratosis of areola superimposed with naevus comedonicus?
  • [MeSH-major] Breast Diseases / pathology. Epidermis / pathology. Keratosis / pathology. Nevus / pathology

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  • (PMID = 16987287.001).
  • [ISSN] 0926-9959
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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28. Köse O, Calişkan E, Kurumlu Z: Three different epidermal naevi with no organ involvement: sebaceous naevus, naevus comedonicus and Becker's naevus. Acta Derm Venereol; 2008;88(1):67-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Three different epidermal naevi with no organ involvement: sebaceous naevus, naevus comedonicus and Becker's naevus.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Nevus / pathology. Nevus, Sebaceous of Jadassohn / pathology. Skin Neoplasms / pathology

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  • (PMID = 18176758.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Sweden
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29. Monteagudo Sánchez B, Ginarte Val M, León Muiños E, Vázquez Golpe R, Varela Iglesias A: [Nevus comedonicus]. An Pediatr (Barc); 2006 Aug;65(2):171-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Nevus comedonicus].
  • [Transliterated title] Nevo comedoniano.

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  • (PMID = 16948985.001).
  • [ISSN] 1695-4033
  • [Journal-full-title] Anales de pediatría (Barcelona, Spain : 2003)
  • [ISO-abbreviation] An Pediatr (Barc)
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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30. Bhagwat PV, Tophakhane RS, Rathod RM, Tonita NM, Naidu V: Nevus comedonicus along Blaschko's lines. Indian J Dermatol Venereol Leprol; 2009 May-Jun;75(3):330
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus comedonicus along Blaschko's lines.
  • [MeSH-major] Nevus / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 19439909.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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31. Bordel MT, Miranda A: [Unilateral nevus comedonicus: efficacy after treatment with 12% ammonium lactate]. Actas Dermosifiliogr; 2006 Mar;97(2):150
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Unilateral nevus comedonicus: efficacy after treatment with 12% ammonium lactate].
  • [Transliterated title] Nevo comedoniano unilateral: eficacia tras el tratamiento con lactato amónico al 12%.
  • [MeSH-major] Dermatologic Agents / therapeutic use. Lactic Acid / therapeutic use. Nevus, Pigmented / drug therapy. Quaternary Ammonium Compounds / therapeutic use. Skin Neoplasms / drug therapy

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  • (PMID = 16595123.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Quaternary Ammonium Compounds; 33X04XA5AT / Lactic Acid
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32. Givan J, Hurley MY, Glaser DA: Nevus comedonicus: a novel approach to treatment. Dermatol Surg; 2010 May;36(5):721-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus comedonicus: a novel approach to treatment.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Lasers, Semiconductor / therapeutic use. Low-Level Light Therapy / methods. Nevus, Pigmented / therapy. Sweat Gland Neoplasms / therapy. Tretinoin / administration & dosage

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  • (PMID = 20384735.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 5688UTC01R / Tretinoin
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33. Martinez M, Levrero P, Bazzano C, Larre Borges A, De Anda G: Nevus comedonicus syndrome in a woman with Paget bone disease and breast cancer: a mere coincidence? Eur J Dermatol; 2006 Nov-Dec;16(6):697-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus comedonicus syndrome in a woman with Paget bone disease and breast cancer: a mere coincidence?
  • [MeSH-major] Breast Neoplasms / pathology. Nevus / pathology. Osteitis Deformans / pathology. Skin Neoplasms / pathology


34. Alpsoy E, Durusoy C, Ozbilim G, Karpuzoğlu G, Yilmaz E: Nevus comedonicus syndrome: a case associated with multiple basal cell carcinomas and a rudimentary toe. Int J Dermatol; 2005 Jun;44(6):499-501
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus comedonicus syndrome: a case associated with multiple basal cell carcinomas and a rudimentary toe.
  • [MeSH-major] Carcinoma, Basal Cell / diagnosis. Nevus, Pigmented / diagnosis. Skin Neoplasms / diagnosis. Toes / abnormalities

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  • (PMID = 15941441.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dermatologic Agents; 5688UTC01R / Tretinoin; 74469-00-4 / Amoxicillin-Potassium Clavulanate Combination; W9WZN9A0GM / Benzoyl Peroxide
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