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Items 1 to 64 of about 64
1. Diegel CR, Cho KR, El-Naggar AK, Williams BO, Lindvall C: Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma. Cancer Res; 2010 Nov 15;70(22):9143-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.
  • Cross-talk between the canonical Wnt and mammalian target of rapamycin (mTOR) signaling pathways occurs at multiple levels in the cell and likely contributes to the oncogenic effects of these pathways in human cancer.
  • To gain more insight into the interplay between Wnt and mTOR signaling in salivary gland tumorigenesis, we developed a mouse model in which both pathways are constitutively activated by the conditional inactivation of the Apc and Pten tumor suppressor genes.
  • Loss of either Apc or Pten alone did not cause tumor development.
  • However, deletion of both genes resulted in the formation of salivary gland tumors with 100% penetrance and short latency that showed a remarkable morphologic similarity to human acinic cell carcinoma.
  • Treatment of tumor-bearing mice using the mTOR inhibitor rapamycin led to complete regression of tumors, indicating that tumor growth was dependent on continued mTOR signaling.
  • Importantly, we found that human salivary gland acinic cell carcinomas also express markers of activated mTOR signaling.
  • Together, these results suggest that aberrant activation of mTOR signaling plays a pivotal role in acinar cell neoplasia of the salivary gland.
  • Because rapamycin analogues are approved for treating other types of human malignancies, our findings suggest that rapamycin therapy should be evaluated for treating patients with salivary gland acinic cell carcinoma.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / deficiency. Carcinoma, Acinar Cell / metabolism. PTEN Phosphohydrolase / deficiency. Salivary Glands / metabolism. TOR Serine-Threonine Kinases / metabolism
  • [MeSH-minor] Animals. Antibiotics, Antineoplastic / pharmacology. Apoptosis / drug effects. Female. Flow Cytometry. Humans. Immunohistochemistry. Male. Mice. Mice, 129 Strain. Mice, Knockout. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / metabolism. Salivary Gland Neoplasms / pathology. Signal Transduction / drug effects. Sirolimus / pharmacology. Tumor Burden / drug effects


2. Prieto-Rodríguez M, Artés-Martínez MJ, Navarro-Hervás M, Camañas-Sanz A, Vera-Sempere FJ: Cytological characteristics of acinic cell carcinoma (ACC) diagnosed by fine-needle aspiration biopsy (FNAB). A study of four cases. Med Oral Patol Oral Cir Bucal; 2005 Mar-Apr;10(2):103-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytological characteristics of acinic cell carcinoma (ACC) diagnosed by fine-needle aspiration biopsy (FNAB). A study of four cases.
  • OBJECTIVE: To present the cytopathological characteristics of acinic cell carcinoma (ACC) as well as its cyto-histological correlation, commenting on the differential diagnostic problems of this entity based on four observations studied using fine-needle aspiration biopsy (FNAB).
  • DISCUSSION: FNAB provides essential information on the diagnostic-therapeutic management of salivary gland tumors; this methodology is highly sensitive in its diagnostic efficacy.
  • The diagnosis of ACCs frequently presents difficulties, owing to the great cytologic similarity of the tumor cells with the normal acinar component of the salivary gland.
  • The differential diagnosis is considered, fundamentally, with clear cell carcinomas, mucoepidermoid carcinomas, Warthin s tumor, and oncocytomas.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands / pathology

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  • (PMID = 15735541.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng; spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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3. Roy S, Dhingra KK, Gupta P, Khurana N, Gupta B, Meher R: Acinic cell carcinoma with extensive neuroendocrine differentiation: a diagnostic challenge. Head Neck Pathol; 2009 Jun;3(2):163-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acinic cell carcinoma with extensive neuroendocrine differentiation: a diagnostic challenge.
  • Primary salivary gland carcinoma with neuroendocrine differentiation is of rare occurrence, especially so in the parotid gland.
  • Amongst the various reported primary tumors with neuroendocrine differentiation, acinic cell carcinoma (ACC) one such tumor.
  • Fine Needle Aspiration Cytology (FANC) yielded a cystic fluid suggesting a possibility of Warthin's tumor or Oncocytic lesion.
  • Intraoperative findings were suggestive of a Warthin's tumor.
  • Initial histopathological examination of the tumor was suggestive of neuroendocrine carcinoma.
  • The possibility of neuroendocrine differentiation in a primary salivary gland tumor should be kept in mind whenever a salivary gland tumor shows only neuroendocrine histology.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19644544.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; Acinic cell / Carcinoma / Chromogranin / Neuroendocrine / Parotid / Warthin’s
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4. Chen AM, Garcia J, Granchi PJ, Johnson J, Eisele DW: Late recurrence from salivary gland cancer: when does "cure" mean cure? Cancer; 2008 Jan 15;112(2):340-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Late recurrence from salivary gland cancer: when does "cure" mean cure?
  • BACKGROUND: The purpose of the current study was to determine the incidence of late recurrences, which were defined as those occurring >or=5 years after initial therapy, among patients treated for salivary gland cancer.
  • METHODS: Between 1960 and 2000, 145 patients underwent definitive therapy for localized carcinomas of the salivary glands and were clinically without evidence of disease at 5 years of follow-up.
  • The crude rates of late recurrence by histologic subtype were adenoid cystic carcinoma (26%), mixed malignant tumor (25%), mucoepidermoid carcinoma (17%), adenocarcinoma (10%), and acinic cell carcinoma (8%).
  • CONCLUSIONS: A significant proportion of patients who are presumed to be cured of their disease at 5 years after initial treatment for salivary gland cancer will be found to develop late disease recurrence with additional follow-up.
  • [MeSH-major] Neoplasm Recurrence, Local / epidemiology. Salivary Gland Neoplasms / mortality

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  • (PMID = 18008358.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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5. Williams MD, Chakravarti N, Kies MS, Maruya S, Myers JN, Haviland JC, Weber RS, Lotan R, El-Naggar AK: Implications of methylation patterns of cancer genes in salivary gland tumors. Clin Cancer Res; 2006 Dec 15;12(24):7353-8
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  • [Title] Implications of methylation patterns of cancer genes in salivary gland tumors.
  • PURPOSE: We investigated the methylation status and protein expression of four tumor suppressor genes to determine their role in salivary gland tumorigenesis.
  • EXPERIMENTAL DESIGN: We performed methylation-specific PCR and protein analyses of 29 normal salivary glands, 23 benign, and 79 malignant salivary gland neoplasms to determine the pattern and potential diagnostic and/or biological role of the RASSF1, RARbeta2, DAPK, and MGMT tumor suppressor gene methylation in these tumors.
  • Methylation occurred in 33 of 79 (41.8%) malignant tumors; 8 (30.8%) adenoid cystic carcinomas, 6 (33.3%) mucoepidermoid carcinomas, 6 (42.9%) acinic cell carcinomas, and 13 (62.0%) salivary duct carcinomas.
  • RASSF1 and RARbeta2 represented 75.8% of methylation events occurring most frequently in salivary duct and acinic cell carcinomas.
  • CONCLUSIONS: (a) Benign and malignant salivary tumors differed in the frequency and pattern of gene methylation;.
  • [MeSH-major] Carcinoma / metabolism. DNA Methylation. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Apoptosis Regulatory Proteins / metabolism. Calcium-Calmodulin-Dependent Protein Kinases / metabolism. Carcinoma, Acinar Cell / metabolism. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Child. DNA Modification Methylases. DNA Repair Enzymes. Death-Associated Protein Kinases. Female. Gene Expression Regulation, Neoplastic. Genes, Neoplasm. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism. Receptors, Retinoic Acid / metabolism. Tumor Suppressor Protein p14ARF / metabolism. Tumor Suppressor Proteins / metabolism

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  • (PMID = 17189407.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / Neoplasm Proteins; 0 / RASSF1 protein, human; 0 / Receptors, Retinoic Acid; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Proteins; 0 / retinoic acid receptor beta; EC 2.1.1.- / DNA Modification Methylases; EC 2.1.1.63 / MGMT protein, human; EC 2.7.11.1 / Death-Associated Protein Kinases; EC 2.7.11.17 / Calcium-Calmodulin-Dependent Protein Kinases; EC 6.5.1.- / DNA Repair Enzymes
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6. Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 8 expression in salivary gland tumors. Head Neck Pathol; 2008 Sep;2(3):169-74
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  • [Title] Human kallikrein 8 expression in salivary gland tumors.
  • The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum.
  • The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Kallikreins / metabolism. Salivary Gland Neoplasms / metabolism. Salivary Glands, Minor / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Humans. Immunoenzyme Techniques

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  • (PMID = 20614312.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK8 protein, human; EC 3.4.21.- / Kallikreins
  • [Other-IDs] NLM/ PMC2807567
  • [Keywords] NOTNLM ; Human kallikrein 8 / Immunohistochemistry / Kallikreins / Prognostic markers / Salivary gland tumors
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7. Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP: [Human kallikrein 13 expression in salivary gland tumors]. Int J Biol Markers; 2006 Apr-Jun;21(2):106-110

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Human kallikrein 13 expression in salivary gland tumors].
  • Petraki et al have previously described presence of hK13 in salivary gland tissue, localized to duct epithelia and some acinar cells.
  • The aim of this study was to determine whether hK13 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid carcinomas (MEC) and adenocarcinomas not otherwise specified (ANOS) of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of hK13.
  • Overall, staining in PA was significantly less than that seen in normal salivary gland tissue.
  • PLGA, ACC and ANOS each stained significantly more than normal salivary gland tissue while MEC and ACI did not.
  • In conclusion, we demonstrate the high expression of hK13 in several common salivary gland tumors.

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  • (PMID = 28207129.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] ita
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Italy
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8. Drut R, Giménez PO: Acinic cell carcinoma of salivary gland with massive deposits of globular amyloid. Int J Surg Pathol; 2008 Apr;16(2):202-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acinic cell carcinoma of salivary gland with massive deposits of globular amyloid.
  • We present the case of a 23-year-old woman with a parotid gland tumor, the fine-needle aspiration biopsy smears of which showed epithelial cells with wide cytoplasm, isolated or arranged in micropapillary groups together with psammoma bodies.
  • The surgical specimen contained a 5-cm tumor with the histologic features of an acinic cell carcinoma (ACC) with papillary areas.
  • Notably, the cells of the tumor seemed to follow a sequence from large cells with rounded nuclei with open chromatin and prominent nucleoli to vacuolated cells with granular material, and finally to cells undergoing apoptosis.
  • Huge globular amyloid deposits, the suggested name for this material irrespective of the type of amyloid, have not been previously reported in ACC of salivary gland.
  • [MeSH-major] Amyloid / metabolism. Carcinoma, Acinar Cell / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Birefringence. Cellular Structures / pathology. Coloring Agents. Congo Red. Female. Humans

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  • (PMID = 18417682.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid; 0 / Biomarkers, Tumor; 0 / Coloring Agents; 3U05FHG59S / Congo Red
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9. Shet T, Ghodke R, Kane S, Chinoy RN: Cytomorphologic patterns in papillary cystic variant of acinic cell carcinoma of the salivary gland. Acta Cytol; 2006 Jul-Aug;50(4):388-92
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  • [Title] Cytomorphologic patterns in papillary cystic variant of acinic cell carcinoma of the salivary gland.
  • OBJECTIVE: To study the cytomorphologic profile of the papillary and cystic variant of acinic cell carcinoma (ACC-PCV) of the salivary glands.
  • However, common to all was a papillary pattern and a cystic fluid background with or without mucin blobs; that led to misdiagnosing the tumor as mucoepidermoid carcinoma on 2 occasions.
  • The granular cells were similar to those seen in the usual acinic cell carcinoma but were smaller.
  • The tumor did not show any acinar pattern and lacked naked nuclei in the background.
  • CONCLUSION: ACC-PCV is papillary and cystic and hence is often not recognized as acinic cell carcinoma.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Cysts / pathology. Salivary Glands / pathology

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  • (PMID = 16901000.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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10. Liu T, Zhu E, Wang L, Okada T, Yamaguchi A, Okada N: Abnormal expression of Rb pathway-related proteins in salivary gland acinic cell carcinoma. Hum Pathol; 2005 Sep;36(9):962-70
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  • [Title] Abnormal expression of Rb pathway-related proteins in salivary gland acinic cell carcinoma.
  • Salivary gland acinic cell carcinoma (ACC) is a relatively rare neoplasm, and limited information is available regarding its molecular pathogenesis.
  • The expression of topoisomerase II-alpha and Ki-67 was also examined to evaluate cell proliferation.
  • The numbers of positive cells for pRb-S795 and cyclin D1 significantly increased in ACCs as compared with normal salivary glands.
  • Double immunofluorescent staining demonstrated that pRb-S795 was colocalized with cyclin D1 in most tumor cells.
  • [MeSH-major] Carcinoma, Acinar Cell / metabolism. Retinoblastoma Protein / metabolism. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Antigens, Neoplasm / metabolism. Cyclin D1 / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. DNA Topoisomerases, Type II / metabolism. DNA-Binding Proteins / metabolism. Female. Humans. Immunohistochemistry. Ki-67 Antigen / metabolism. Male. Middle Aged

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  • (PMID = 16153458.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / Ki-67 Antigen; 0 / Retinoblastoma Protein; 136601-57-5 / Cyclin D1; EC 5.99.1.3 / DNA Topoisomerases, Type II; EC 5.99.1.3 / DNA topoisomerase II alpha
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11. Tanahashi C, Yabuki S, Akamine N, Yatabe Y, Ichihara S: Pure acinic cell carcinoma of the breast in an 80-year-old Japanese woman. Pathol Int; 2007 Jan;57(1):43-6
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  • [Title] Pure acinic cell carcinoma of the breast in an 80-year-old Japanese woman.
  • Acinic cell carcinoma of the breast is an uncommon neoplasm.
  • Since the first case of this rare variant of breast carcinoma was reported in 1996, only 10 cases have been reported in the English-language literature.
  • Reported herein is the first case of primary acinic cell carcinoma of the breast in a Japanese woman.
  • To the naked eye, the tumor appeared well circumscribed and the cut surface was grayish-pink and hemorrhaging.
  • Microscopically, the tumor was predominantly made up of a monotonous proliferation of cells with a finely granular cytoplasm, resembling acinic cells of the parotid gland.
  • In spite of extensive sampling, no common histological patterns of breast carcinoma such as in situ and invasive ductal carcinoma were recognized in the present case, indicating that the present case was pure acinic cell carcinoma.
  • In addition, the immunohistochemical profile of this tumor was identical to that of the acinic cell carcinoma of the salivary gland: estrogen receptor, progesterone receptor, HER2 and cytokeratin (CK)20 were negative and amylase and CK7 were positive.
  • The patient has been well for 22 months since the wide local excision of the tumor and no signs of salivary neoplasm are evident to date.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / pathology


12. Luukkaa H, Laitakari J, Vahlberg T, Klemi P, Grénman R: Morphometric analysis using automated image analysis of CD34-positive vessels in salivary gland acinic cell carcinoma. Acta Otolaryngol; 2007 Aug;127(8):869-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Morphometric analysis using automated image analysis of CD34-positive vessels in salivary gland acinic cell carcinoma.
  • CONCLUSIONS: In computer-assisted analysis of acinic cell cancer (ACC) morphological characteristics of CD34 immunoreactivity were detected.
  • OBJECTIVES: Salivary gland cancer (SGC) is a morphologically diverse group of malignancies, the most common histological types being mucoepidermoid, adenoid cystic and ACC, which has the most favorable prognosis of the three.
  • [MeSH-major] Antigens, CD34 / immunology. Carcinoma, Acinar Cell / pathology. Epithelial Cells / immunology. Image Processing, Computer-Assisted / methods. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Densitometry / methods. Female. Finland / epidemiology. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging / methods. Prevalence. Prognosis

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  • (PMID = 17763000.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Antigens, CD34
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13. Weiler C, Reu S, Zengel P, Kirchner T, Ihrler S: Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma. Pathol Res Pract; 2009;205(12):838-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma.
  • The differential diagnosis between benign salivary oncocytoma (ONC) and low-grade malignant acinic cell carcinoma (ACC) can be difficult due to a significant histomorphological overlap of the structural and cytological presentation of both tumor types.
  • The statistically significant stronger expression of CK7 in ONC and stronger expression of PAS and alpha-amylase in ACC in routine practice each is hampered by a pronounced overlap between both tumor groups.
  • The obligate presence of an additional small basal cell component in all cases of ONC, demonstrable with p63 and CK5/6, enables a straightforward distinction from ACC, being constantly devoid of a basal cell component.
  • The detection of this basal cell component in ONC in routine Hematoxylin-eosin stain is difficult and in some cases not possible; therefore, immunohistochemistry with p63 or CK5/6 is recommended for selected cases.
  • [MeSH-major] Adenoma, Oxyphilic / pathology. Biomarkers, Tumor / analysis. Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-5 / analysis. Keratin-6 / analysis. Male. Middle Aged. Predictive Value of Tests. Trans-Activators / analysis. Transcription Factors. Tumor Suppressor Proteins / analysis

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  • (PMID = 19646823.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / KRT5 protein, human; 0 / Keratin-5; 0 / Keratin-6; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
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14. Tavora F, Rassaei N, Shilo K, Foss RD, Galvin JR, Travis WD, Franks TJ: Occult primary parotid gland acinic cell adenocarcinoma presenting with extensive lung metastasis. Arch Pathol Lab Med; 2007 Jun;131(6):970-3
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  • [Title] Occult primary parotid gland acinic cell adenocarcinoma presenting with extensive lung metastasis.
  • Acinic cell adenocarcinoma is a malignant salivary gland neoplasm with a relatively low rate of lymphangitic spread to regional lymph nodes.
  • We encountered an unusual example of acinic cell adenocarcinoma that initially presented in the lung, whereas the primary parotid carcinoma, despite extensive clinical evaluation, only became apparent 1 year after initial diagnosis.
  • The histologic, immunohistochemical, and ultrastructural features of the tumor in the parotid gland and lung were similar.
  • The tumor displayed an aggressive behavior resulting in death within 2 years of the initial presentation.
  • This presentation is unique, showing that peripheral lung tumors of salivary gland type are likely to be metastatic, and careful clinical evaluation is warranted in establishing their primary site of origin.
  • [MeSH-major] Carcinoma, Acinar Cell / secondary. Lung Neoplasms / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Fatal Outcome. Female. Humans. Palliative Care

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  • (PMID = 17550329.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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15. Kinkor Z, Skálová A: [Acinic cell-like differentiation in invasive ductal carcinoma and in ductal hyperplasia of the breast--report of two cases]. Cesk Patol; 2005 Jan;41(1):29-33
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  • [Title] [Acinic cell-like differentiation in invasive ductal carcinoma and in ductal hyperplasia of the breast--report of two cases].
  • [Transliterated title] "Acinic cell-like" diferenciace v invazivním duktálním karcinomu a duktální hyperlazii mlécné zlázy--popis dvou prípadů.
  • Described are two epithelial lesions of the breast displaying extremely rare, widespread acinic cell-like differentiation (metaplasia).
  • Two women, 70 and 40-year-old, one with invasive ductal papillocarcinoma, the other one with conventional intraductal hyperplasia without atypia, both demonstrated massive diffuse, PAS positive, granular eosinophilic transformation of the cell cytoplasm.
  • This unusual cell appearance closely simulated acinar cells in normal serous salivary gland/acinic cell carcinoma or Paneth cells.
  • Both extensive expression of lysozyme and finding of numerous zymogen granules ultrastructurally confirmed the acinic cell-like fenotype.
  • Discussed is differential diagnosis of the breast neoplasm containing overt eosinophilic and granular cytoplasm.
  • Reviewing literature and comparing our unique finding of unusual salivary-type differentiation in conventional ductal hyperplasia of the breast, biologic implications are considered.
  • [MeSH-major] Breast Neoplasms / pathology. Carcinoma, Acinar Cell / pathology. Carcinoma, Ductal, Breast / pathology


16. Triantafillidou K, Iordanidis F, Psomaderis K, Kalimeras E: Acinic cell carcinoma of minor salivary glands: a clinical and immunohistochemical study. J Oral Maxillofac Surg; 2010 Oct;68(10):2489-96
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  • [Title] Acinic cell carcinoma of minor salivary glands: a clinical and immunohistochemical study.
  • PURPOSE: Acinic cell carcinoma is a rare malignant tumor of salivary glands.
  • The purpose of this study is to evaluate the clinical outcome of acinic cell carcinoma in a group of 11 patients, who were treated in our clinic, and to discuss the management as well as the immunohistochemical features and prognosis of this carcinoma.
  • MATERIALS AND METHODS: The study included 11 patients with acinic cell carcinoma of the minor salivary glands who were treated in our clinic.
  • CONCLUSIONS: Acinic cell carcinoma is a rare malignant tumor of the salivary glands, characterized by an indolent clinical course with the potential for both local recurrence and distant metastases.
  • The immunohistochemical analysis of proliferation markers provides additional prognostic information for this tumor.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease-Free Survival. Female. Follow-Up Studies. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Staging. Prognosis. Receptor, Epidermal Growth Factor / analysis. Receptor, ErbB-2 / analysis. Treatment Outcome. Tumor Suppressor Protein p53 / analysis

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  • [Copyright] Copyright © 2010. Published by Elsevier Inc.
  • (PMID = 20678839.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
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17. Hammami B, Dhouib H, Sallemi M, Ben Hmida A, Ben Mahfoudh K, Daoud J, Ghorbel A: [Acinic cell carcinoma of the nasal septum]. Rev Stomatol Chir Maxillofac; 2010 Apr;111(2):88-90
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  • [Title] [Acinic cell carcinoma of the nasal septum].
  • [Transliterated title] Carcinome à cellules acineuses du septum nasal.
  • INTRODUCTION: Nasal cavity acinic carcinoma are exceptional and often of turbinal origin.
  • We report a case of acinic carcinoma of septal origin and discuss this histological type rare in this site.
  • The surgical treatment was endonasal tumor resection.
  • The histological examination revealed a nasal fossa acinic carcinoma completely resected.
  • DISCUSSION: Acinic carcinoma is rarely located in the nasal cavity.
  • It is usually located at the salivary gland level.
  • The prognosis is related to tumor extension and quality of resection.
  • [MeSH-major] Carcinoma, Acinar Cell / surgery. Nasal Septum / pathology. Nose Neoplasms / surgery

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  • (PMID = 19942241.001).
  • [ISSN] 1776-257X
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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18. Cohn ML, Elliott DD, El-Naggar AK: Metastatic acinic cell carcinoma in a neurofibroma mistaken for carcinosarcoma. Head Neck; 2005 Jan;27(1):76-80
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  • [Title] Metastatic acinic cell carcinoma in a neurofibroma mistaken for carcinosarcoma.
  • BACKGROUND: Tumor-to-tumor metastasis is a rare, but well-recognized, entity most commonly involving metastatic carcinoma to a mesenchymal neoplasm.
  • We report a case of acinic cell carcinoma of the parotid gland metastatic to a neurofibroma.
  • METHODS AND RESULTS: A 55-year-old man with a history of a high-grade acinic cell carcinoma of the parotid was seen with a mass at the surgical site and metastatic foci in the scalp 10 months postoperatively.
  • The resection specimen revealed a spindle cell lesion with metastatic foci of high-grade adenocarcinoma, initially diagnosed as a carcinosarcoma.
  • The bland morphology and S-100-positive expression of the spindle cell lesion confirmed the diagnosis of neurofibroma.
  • The high-grade features of the carcinomatous foci and their similarity to the primary tumor confirmed the presence of a tumor-to-tumor metastasis.
  • CONCLUSION: To our knowledge, this is the first reported case of acinic cell carcinoma metastatic to a neurofibroma, an important entity in the differential diagnosis of biphasic tumors of the head and neck.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Carcinosarcoma / pathology. Neoplasms, Multiple Primary / pathology. Neurofibroma / pathology. Parotid Neoplasms / pathology. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright 2004 Wiley Periodicals, Inc.
  • (PMID = 15565563.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Varsegi MF, Ravis SM, Hattab EM, Henley JD, Billings SD: Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation. J Cutan Pathol; 2008 Jun;35(6):591-3
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  • [Title] Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation.
  • Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm.
  • We present a case of widespread cutaneous metastasis from acinic cell carcinoma arising in a 59-year-old woman with a history of acinic cell carcinoma of the parotid gland 20 years prior to her cutaneous disease.
  • To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma.
  • [MeSH-major] Carcinoma, Acinar Cell / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Biopsy. Cell Nucleus / pathology. Cytoplasmic Granules / pathology. Female. Humans. Middle Aged. Periodic Acid-Schiff Reaction

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  • (PMID = 18261112.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Omlie JE, Koutlas IG: Acinic cell carcinoma of minor salivary glands: a clinicopathologic study of 21 cases. J Oral Maxillofac Surg; 2010 Sep;68(9):2053-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acinic cell carcinoma of minor salivary glands: a clinicopathologic study of 21 cases.
  • PURPOSE: Acinic cell carcinoma (ACC) is an infrequent type of malignant salivary gland tumor.
  • After properly diagnosed and treated, this patient has been free of tumor for 4 years.
  • Of interest were the metachronous occurrence of lymphoma in 1 patient and the synchronous occurrence of renal cell carcinoma in another.
  • CONCLUSION: This study confirms the indolent behavior of ACC of minor salivary glands and previous reports on the occasional synchronous or metachronous association of malignant salivary gland tumors with other malignancies.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Neoplasms, Multiple Primary. Neoplasms, Second Primary. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Carcinoma, Renal Cell / parasitology. Female. Humans. Kidney Neoplasms / pathology. Lymph Nodes / pathology. Lymphoma / pathology. Male. Middle Aged. Young Adult

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  • [Copyright] Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
  • (PMID = 20576339.001).
  • [ISSN] 1531-5053
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Negahban S, Daneshbod Y, Khademi B, Seif I: Papillary cystic acinic cell carcinoma with many psammoma bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings. Acta Cytol; 2009 Jul-Aug;53(4):440-4
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  • [Title] Papillary cystic acinic cell carcinoma with many psammoma bodies, so-called psammoma body-rich papillary cystic acinic cell carcinoma: report of a case with fine needle aspiration findings.
  • Psammoma bodies are infrequent in salivary gland aspirates.
  • We present a case of papillary cystic acinic cell carcinoma with many psammoma bodies and discuss the diagnostic pitfalls with other salivary gland tumors.
  • A preliminary diagnosis of papillary cystic salivary gland neoplasm was made and supeficial parotidectomy performed.
  • A diagnosis of papillary cystic acinic cell carcinoma with many psammoma bodies was made.
  • Aspiration cytology of papillary cystic acinic cell carcinoma with many psammoma bodies can be confused with more common tumors, such as cystic mixed tumor and adenoid cystic carcinoma with cannonballs, low grade mucoepidermoid carcinoma or cystic papillary carcinoma of the thyroid.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Carcinoma, Papillary / pathology. Diagnosis, Differential. Female. Humans

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  • (PMID = 19697733.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. da Silva AA, Graner E, Jorge J, Vargas PA, Lopes MA: Intraoral acinic cell carcinoma: case report and review of the literature. Gen Dent; 2008 Nov-Dec;56(7):e43-5
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  • [Title] Intraoral acinic cell carcinoma: case report and review of the literature.
  • Acinic cell carcinoma (ACC) is an uncommon salivary gland tumor that primarily affects the parotid gland.
  • Involvement of minor salivary glands is rare.
  • Histologically, the tumor was characterized by cells that resembled the serous cells.
  • [MeSH-major] Carcinoma, Acinar Cell / diagnosis. Mouth Neoplasms / diagnosis

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  • (PMID = 21444272.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Psalla D, Geigy C, Konar M, Café Marçal V, Oevermann A: Nasal acinic cell carcinoma in a cat. Vet Pathol; 2008 May;45(3):365-8
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  • [Title] Nasal acinic cell carcinoma in a cat.
  • This case report describes the clinical, magnetic resonance imaging (MRI)-related, and pathologic features of a nasal acinic cell carcinoma in a cat.
  • Evaluation by MRI revealed an heterogeneous, space-occupying lesion that filled the left nasal cavity and was diagnosed by histopathologic examination as an acinic cell carcinoma arising from a minor salivary gland of the nasal cavity.
  • Acinic cell carcinoma is a rare tumor in veterinary medicine.
  • The tumor is composed mainly of cells resembling serous cells of salivary glands and originates from major or minor salivary glands.
  • Clinicians and pathologists should be aware of the occurrence of acinic cell carcinoma in the sinonasal tract and include the tumor in the differential diagnosis of feline nasal diseases.
  • [MeSH-major] Carcinoma, Acinar Cell / veterinary. Paranasal Sinus Neoplasms / veterinary
  • [MeSH-minor] Animals. Cats. Keratins / analysis. Magnetic Resonance Imaging. Male. Nasal Cavity / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 18487495.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 68238-35-7 / Keratins
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24. Delides A, Velegrakis G, Kontogeorgos G, Karagianni E, Nakas D, Helidonis E: Familial bilateral acinic cell carcinoma of the parotid synchronous with pituitary adenoma: case report. Head Neck; 2005 Sep;27(9):825-8
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  • [Title] Familial bilateral acinic cell carcinoma of the parotid synchronous with pituitary adenoma: case report.
  • BACKGROUND: Acinic cell carcinoma is a common neoplasm of the salivary glands that occurs predominately in the parotid.
  • Only one case of a familial recurrence of such a neoplasm and 16 cases of bilateral tumors have been reported.
  • METHODS: History files and histologic reports of a patient with bilateral multifocal acinic cell carcinoma of the parotid and a synchronous pituitary adenoma, and of the patient's sister and his father, also treated for parotid tumours, were retrieved.
  • RESULTS: There was one recurrence of acinic cell carcinoma in the family.
  • A pituitary tumor was a chromophobe gonotrophic adenoma.
  • CONCLUSIONS: This is the 17th case of bilateral acinic cell carcinoma of the parotid gland and the second reported case with a familial recurrence.
  • [MeSH-major] Adenoma / diagnosis. Carcinoma, Acinar Cell / diagnosis. Neoplasms, Multiple Primary / diagnosis. Parotid Neoplasms / diagnosis. Pituitary Neoplasms / diagnosis

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 15920750.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Cho JH, Yoon SY, Bae EY, Lee CN, Lee JD, Cho SH: Acinic cell carcinoma on the lower lip resembling a mucocele. Clin Exp Dermatol; 2005 Sep;30(5):490-3
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  • [Title] Acinic cell carcinoma on the lower lip resembling a mucocele.
  • Positive staining was observed with Periodic acid-Shiff, and immunohistochemistry for cytokeratin, alpha-1 antitrypsin, and S-100 protein resulting in a final diagnosis of acinic cell carcinoma.
  • Acinic cell carcinoma represents a well-established, although uncommon, entity in the classification of neoplasms of salivary gland origin.
  • The parotid salivary gland is the most frequent site of acinic cell carcinoma, whereas the lip is a particularly unusual site.
  • Given these findings, we suggest that acinic cell carcinoma should be considered in the differential diagnosis of any mucocele-like mass on the lower lip.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Lip Neoplasms / pathology. Mucocele / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 16045674.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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26. Shigeishi H, Ohta K, Hiraoka M, Fujimoto S, Minami M, Higashikawa K, Kamata N: Expression of TPX2 in salivary gland carcinomas. Oncol Rep; 2009 Feb;21(2):341-4
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  • [Title] Expression of TPX2 in salivary gland carcinomas.
  • The purpose of this study was to clarify the expression of TPX2 mRNA and correlation between TPX2 and clinicopathological factors in salivary gland carcinomas.
  • The expression of TPX2 mRNA was investigated in 20 human salivary gland carcinomas (8 mucoepidermoid carcinomas, 7 adenoid cystic carcinomas, 5 acinic cell carcinomas) and 6 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
  • The mean expression levels of TPX2 were also higher in acinic cell carcinomas (0.45+/-0.49) and adenoid cystic carcinomas (0.28+/-0.22) than in normal submandibular glands.
  • These results indicate that human TPX2 mRNA is closely linked to increased or abnormal cell proliferation in malignant salivary gland tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma / metabolism. Cell Cycle Proteins / biosynthesis. Microtubule-Associated Proteins / biosynthesis. Nuclear Proteins / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 19148505.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antigens, CD44; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Extracellular Matrix Proteins; 0 / Microtubule-Associated Proteins; 0 / Nuclear Proteins; 0 / RNA, Messenger; 0 / TPX2 protein, human; 0 / hyaluronan-mediated motility receptor
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27. Andreadis D, Epivatianos A, Poulopoulos A, Nomikos A, Papazoglou G, Antoniades D, Barbatis C: Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours. Oral Oncol; 2006 Jan;42(1):57-65
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  • [Title] Detection of C-KIT (CD117) molecule in benign and malignant salivary gland tumours.
  • In the present study we analysed the expression of this molecule in salivary gland tumours.
  • Archival formalin-fixed, paraffin-embedded sections of 40 benign and 57 malignant salivary gland tumours were retrieved and retrospectively studied immunohistochemically using a polyclonal C-KIT antibody in an Envision/HRP technique.
  • In addition five samples of chronic submandibular sialadenitis, five normal minor salivary glands and parotid or submandibular gland tissue adjacent to benign tumour were also studied.
  • C-KIT expression was observed in cases of adenoid cystic, acinic cell polymorphous low grade, epithelial-myoepithelial, carcinosarcoma and basal cell adenocarcinomas, as in luminal cells of pleomorphic adenomas, in serous acinar and only in intercalated and a small number of striated ductal cells of inflammatory salivary gland tissue, whereas normal salivary lobules were generally negative except a weak positivity of intercalated cells.
  • Contrary to other reports, this study suggests that, C-KIT protein does not appear to be an exclusively specific marker for benign or malignant salivary gland neoplasms, but may be useful in differential diagnosis of adenoid cystic carcinoma from polymorphous low grade adenocarcinoma.
  • Furthermore its expression in serous acinar cells in sialadenitis and intercalated ductal cells in normal and inflammatory lesions may indicate a possible participation in pathogenesis of both neoplastic and non-neoplastic salivary gland diseases.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Adenoid Cystic / chemistry. Proto-Oncogene Proteins c-kit / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 16140564.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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28. Lee JH, Lee JH, Kim A, Kim I, Chae YS: Unique expression of MUC3, MUC5AC and cytokeratins in salivary gland carcinomas. Pathol Int; 2005 Jul;55(7):386-90
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  • [Title] Unique expression of MUC3, MUC5AC and cytokeratins in salivary gland carcinomas.
  • The differential diagnosis of salivary gland carcinoma is often difficult because of the confusing histopathological features of the different types of salivary gland carcinomas.
  • The expression of MUC3, MUC5AC, MUC6, cytokeratin (CK)7 and CK20 was studied in 20 mucoepidermoid carcinomas (MEC), 20 adenoid cystic carcinomas (AdCC), and 11 acinic cell carcinomas (ACC).
  • These findings will be very useful for the differential diagnosis of the salivary gland carcinomas.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Immunohistochemistry. Intermediate Filament Proteins / biosynthesis. Keratin-20. Keratin-7. Keratins / biosynthesis. Male. Middle Aged. Mucin 5AC. Mucin-3. Mucins / biosynthesis

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  • (PMID = 15982212.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 0 / MUC5AC protein, human; 0 / Mucin 5AC; 0 / Mucin-3; 0 / Mucins; 68238-35-7 / Keratins
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29. Andreadis D, Epivatianos A, Mireas G, Nomikos A, Poulopoulos A, Yiotakis J, Barbatis C: Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours. J Laryngol Otol; 2006 Apr;120(4):298-304
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  • [Title] Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours.
  • OBJECTIVES: To investigate the topography of E-cadherin and its possible correlation with the histological phenotype of salivary gland tumours.
  • MATERIAL AND METHODS: Archival formalin-fixed, paraffin-embedded sections of 54 benign and 56 malignant tumours and 24 samples of normal and inflamed salivary gland tissue were studied immunohistochemically using an Envision/horseraddish peroxidase (HRP) technique.
  • RESULTS: In normal and inflamed salivary gland samples, E-cadherin was expressed at the membrane of acinar, myoepithelial and ductal cells located at cell-cell contact points.
  • Furthermore, a weak to moderate loss of expression which was related to tissue tumour subtype was seen in malignant tumours such as: adenoid cystic carcinomas; polymorphous low-grade adenocarcinomas; acinic cell carcinomas; and mucoepidermoid low-grade, epithelial-myoepithelial, lymphoepithelial and squamous low-grade carcinomas.
  • Moderate to extreme loss or alternative cytoplasmic non-functional expression were observed in cases of salivary ductal carcinoma, carcinosarcoma, myoepithelial carcinoma, oncocytic adenocarcinoma, unspecified adenocarcinoma and squamous high-grade carcinomas.
  • CONCLUSION: This study suggests a direct association of E-cadherin expression with neoplastic histologic phenotype, which is lost in the more undifferentiated and invasive epithelial salivary gland tumours.
  • [MeSH-major] Adenocarcinoma / chemistry. Biomarkers, Tumor / analysis. Cadherins / analysis. Carcinoma, Adenoid Cystic / chemistry. Carcinoma, Ductal / chemistry. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenolymphoma / chemistry. Adenoma / chemistry. Adenoma, Pleomorphic / chemistry. Humans. Immunohistochemistry / methods. Salivary Gland Diseases / metabolism. Salivary Glands / chemistry

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  • (PMID = 16623973.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins
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30. Shapiro NL, Bhattacharyya N: Clinical characteristics and survival for major salivary gland malignancies in children. Otolaryngol Head Neck Surg; 2006 Apr;134(4):631-4
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  • [Title] Clinical characteristics and survival for major salivary gland malignancies in children.
  • OBJECTIVE: Determine presentation and survival rates for malignant pediatric salivary gland neoplasms.
  • METHODS: All cases of malignant neoplasms involving the parotid or submandibular gland in patients ages birth to 18 years were extracted from the Surveillance, Epidemiology, and End Results database (1988-2001).
  • Variables included age, gender, tumor histology, size, follow-up time, and vital status.
  • RESULTS: 113 primary salivary gland malignancies (103 parotid, 10 submandibular) were identified.
  • Mean tumor size was 2.5 cm.
  • Among parotid tumors, there were 44 (43%) mucoepidermoid carcinomas and 35 (34%) acinic cell carcinomas.
  • Mean Kaplan-Meier survival for parotid gland lesions was 153 months, with rhabdomyosarcomas exhibiting significantly worse survivals as compared to other malignancies (P < 0.001, log-rank test).
  • CONCLUSIONS: Both epithelial and mesenchymal tumors present in the pediatric salivary gland.
  • Survival for both parotid and submandibular gland malignancies is good in children.
  • [MeSH-major] Carcinoma, Acinar Cell / mortality. Carcinoma, Mucoepidermoid / mortality. Salivary Gland Neoplasms / mortality

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  • (PMID = 16564387.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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31. Shigeishi H, Yoneda S, Taki M, Nobumori T, Ohta K, Higashikawa K, Yasui W, Kamata N: Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors. Oncol Rep; 2006 Apr;15(4):933-8
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  • [Title] Correlation of human Bub1 expression with tumor-proliferating activity in salivary gland tumors.
  • Human Bub1 plays an important role at the spindle assembly check-point to prevent cell cycle progression following spindle damage.
  • We examined the expression of Bub1 mRNA and protein in 21 human salivary gland tumors (7 pleomorphic adenomas, 2 warthin tumors, 5 mucoepidermoid carcinomas, 3 adenoid cystic carcinomas and 4 acinic cell carcinomas) and 3 normal submandibular glands using real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) or western blotting.
  • We analyzed its relation with the proliferative activity monitored by the Ki-67 labeling index by immunohistochemistry as well as the expression of proliferating cell nuclear antigen (PCNA) by Western blotting.
  • A significant correlation was found between Bub1 mRNA/protein expression and the Ki-67 labeling index in salivary gland tumors (Spearman's correlation coefficient by rank test, p=0.026/p=0.002).
  • These results indicate that increased expression of the human Bub1 gene is closely linked to abnormal cell proliferation in malignant conditions.
  • [MeSH-major] Cell Proliferation. Protein Kinases / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenolymphoma / genetics. Adenolymphoma / metabolism. Adenolymphoma / pathology. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Blotting, Western. Carcinoma, Acinar Cell / genetics. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / genetics. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Ki-67 Antigen / analysis. Neoplasm Staging. Proliferating Cell Nuclear Antigen / analysis. Protein-Serine-Threonine Kinases. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 16525682.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / RNA, Messenger; EC 2.7.- / Protein Kinases; EC 2.7.11.1 / BUB1 protein, human; EC 2.7.11.1 / Bub1 spindle checkpoint protein; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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32. Röser K, Jäkel KT, Herbst H, Löning T: [Immunohistochemical characterization of salivary gland tumors with tissue micro-arrays]. Pathologe; 2005 Sep;26(5):345-52
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  • [Title] [Immunohistochemical characterization of salivary gland tumors with tissue micro-arrays].
  • Systematic analysis of gene expression in salivary gland tumors is necessary to identify genes associated with specific tumor types.
  • From the salivary gland register of the University Hospital Hamburg-Eppendorf sufficient samples of various tumors were available to generate Tissue Micro-Arrays (TMA).
  • In light of the considerable heterogeneity of salivary gland tumors, this study was aimed at evaluating the suitability of TMA in salivary gland diagnostics and research.
  • Epithelial antigens are not sufficient for a tumor-type-specific characterization.
  • Myoepithelial markers are suitable for distinguishing biphasic tumor types from purely epithelial tumors.
  • The detection of amylase in acinic cell carcinomas, and the detection of steroid hormone receptors in these and other malignant salivary gland tumors particularly in combination with the expression of transcription factors, oncogenes and proliferation associated antigens result in characteristic expression profiles.
  • [MeSH-major] Myoepithelioma / genetics. Oligonucleotide Array Sequence Analysis. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Biomarkers, Tumor / analysis. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Receptors, Steroid / genetics. Transcription Factors / genetics

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  • (PMID = 16049672.001).
  • [ISSN] 0172-8113
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Steroid; 0 / Transcription Factors
  • [Number-of-references] 23
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33. Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 13 expression in salivary gland tumors. Int J Biol Markers; 2006 Apr-Jun;21(2):106-10
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  • [Title] Human kallikrein 13 expression in salivary gland tumors.
  • Petraki et al have previously described presence of hK13 in salivary gland tissue, localized to duct epithelia and some acinar cells.
  • The aim of this study was to determine whether hK13 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas (PA), adenoid cystic carcinomas (ACC), polymorphous low grade adenocarcinomas (PLGA), acinic cell carcinomas (ACI), mucoepidermoid carcinomas (MEC) and adenocarcinomas not otherwise specified (ANOS) of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors show high levels of expression of hK13.
  • Overall, staining in PA was significantly less than that seen in normal salivary gland tissue.
  • PLGA, ACC and ANOS each stained significantly more than normal salivary gland tissue while MEC and ACI did not.
  • In conclusion, we demonstrate the high expression of hK13 in several common salivary gland tumors.
  • [MeSH-major] Biomarkers, Tumor. Carcinoma, Adenoid Cystic / metabolism. Gene Expression Regulation, Neoplastic. Kallikreins / biosynthesis. Mouth Mucosa / metabolism. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenoma, Pleomorphic / metabolism. Carcinoma, Mucoepidermoid / metabolism. Humans. Immunohistochemistry. Prognosis. Salivary Glands / metabolism

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  • (PMID = 16847813.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / KLK13 protein, human; EC 3.4.21.- / Kallikreins
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34. Fehr A, Stenman G, Bullerdiek J, Löning T: [Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup]. Pathologe; 2009 Nov;30(6):466-71
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  • [Title] [Molecular markers in salivary gland tumors: their use in diagnostic and prognostic workup].
  • The molecular genetic background of salivary gland neoplasms has not been characterized in detail to date.
  • CRTC1-MAML2 in mucoepidermoid carcinoma, or PLAG1 and HMGA2 in pleomorphic adenoma.
  • One of the major advantages of molecular tumor markers is that valid results are obtained on minute cell and/or tissue samples.
  • This is also true for the most frequent malignant salivary gland tumors after the mucoepidermoid carcinoma, i.e. adenoid cystic carcinomas and acinic cell carcinomas.
  • [MeSH-major] Biomarkers, Tumor / genetics. Neoplasm Proteins / genetics. Salivary Gland Neoplasms / diagnosis. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / pathology. Carcinoma, Acinar Cell. Carcinoma, Adenoid Cystic. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / genetics. Carcinoma, Mucoepidermoid / pathology. Chromosome Aberrations. Comparative Genomic Hybridization. DNA Mutational Analysis. DNA-Binding Proteins. Gene Fusion. HMGA2 Protein. Humans. Nuclear Proteins. Prognosis. Protein Array Analysis. Salivary Glands / pathology. Transcription Factors

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  • (PMID = 19784654.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / HMGA2 Protein; 0 / MAML2 protein, human; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / PLAG1 protein, human; 0 / Transcription Factors
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35. Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, Starek I, Geierova M, Simpson RH, Passador-Santos F, Ryska A, Leivo I, Kinkor Z, Michal M: Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol; 2010 May;34(5):599-608
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  • [Title] Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.
  • We present a series of 16 salivary gland tumors with histomorphologic and immunohistochemical features reminiscent of secretory carcinoma of the breast.
  • This is a hitherto undescribed and distinctive salivary gland neoplasm, with features resembling both salivary acinic cell carcinoma (AciCC) and low-grade cystadenocarcinoma, and displaying strong similarities to breast secretory carcinoma.
  • For this tumor, we propose a designation mammary analogue secretory carcinoma of salivary glands (MASC).
  • Thirteen cases occurred in the parotid gland, and one each in the minor salivary glands of the buccal mucosa, upper lip, and palate.
  • This translocation was not found in any conventional salivary AciCC (12 cases), nor in other tumor types including pleomorphic adenoma (1 case) and low-grade cribriform cystadenocarcinoma (1 case), whereas ETV6-NTRK3 gene rearrangements were proven in all 3 tested cases of mammary secretory carcinoma.
  • [MeSH-major] Cystadenocarcinoma / genetics. Oncogene Proteins, Fusion / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 15. Combined Modality Therapy. Female. Gene Rearrangement. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasms, Multiple Primary. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction. Salivary Glands / surgery. Translocation, Genetic. Treatment Outcome. Young Adult

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  • [CommentIn] Am J Surg Pathol. 2011 Oct;35(10):1600-2 [21934478.001]
  • (PMID = 20410810.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / ETV6-NTRK3 fusion protein, human; 0 / Oncogene Proteins, Fusion; 0 / RNA, Neoplasm
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36. Luukkaa H, Klemi P, Leivo I, Koivunen P, Laranne J, Mäkitie A, Virtaniemi J, Hinkka S, Grénman R: Salivary gland cancer in Finland 1991--96: an evaluation of 237 cases. Acta Otolaryngol; 2005 Feb;125(2):207-14
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  • [Title] Salivary gland cancer in Finland 1991--96: an evaluation of 237 cases.
  • CONCLUSION: In this material consisting of various salivary gland carcinomas, stage I, male gender and age were the most powerful predictors of patient outcome.
  • OBJECTIVES: To retrieve the records of all salivary gland cancer (SGC) patients diagnosed in Finland between 1991 and 1996 and to evaluate the incidence, histological type and location of SGC, the treatment given and the outcome.
  • The commonest tumor location was the parotid gland (n = 152; 64%), followed by the minor salivary glands (n =46; 19%), the submandibular gland (n =38; 16%) and the sublingual gland (n = 1; 0.4%).
  • The most frequent histological types of SGC were adenoid cystic carcinoma (n =65; 27%), mucoepidermoid carcinoma (n =45; 19%) and acinic cell carcinoma (n =41; 17%).
  • Of the commonest tumor types, the best 5-year relative survival rate was for patients with acinic cell carcinoma (96%), followed by those with mucoepidermoid (79%) and adenoid cystic carcinoma (74%).
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / epidemiology. Carcinoma / mortality. Carcinoma / surgery. Female. Finland / epidemiology. Humans. Incidence. Male. Middle Aged. Neoplasm Staging. Parotid Neoplasms / epidemiology. Parotid Neoplasms / mortality. Parotid Neoplasms / surgery. Population Surveillance / methods. Survival Rate

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  • (PMID = 15880955.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
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37. Foschini MP, Krausz T: Salivary gland-type tumors of the breast: a spectrum of benign and malignant tumors including "triple negative carcinomas" of low malignant potential. Semin Diagn Pathol; 2010 Feb;27(1):77-90
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  • [Title] Salivary gland-type tumors of the breast: a spectrum of benign and malignant tumors including "triple negative carcinomas" of low malignant potential.
  • Salivary gland-type neoplasms of the breast are uncommon and comprise numerous entities analogous to that more commonly seen in salivary glands.
  • The clinicopathologic spectrum ranges from benign to malignant but there are important differences as compared with those of their salivary counterpart.
  • In the breast, benign adenomyoepithelioma is recognized in addition to malignant one, whereas in the salivary gland a histologically similar tumor is designated as epithelial-myoepithelial carcinoma without a separate benign subgroup.
  • Mammary adenoid cystic carcinoma is a low-grade neoplasm compared with its salivary equivalent.
  • It is also important to appreciate that in contrast to "triple negative" conventional breast carcinomas with aggressive course, most salivary-type malignant breast neoplasms behave in a low-grade manner.
  • Well established examples of this group include pleomorphic adenoma, adenomyoepithelioma, and adenoid cystic carcinoma.
  • Another family of salivary gland-type mammary epithelial neoplasms is devoid of myoepithelial cells.
  • Key examples include mucoepidermoid carcinoma and acinic cell carcinoma.
  • The number of cases of salivary gland-type mammary neoplasms in the published data is constantly increasing but some of the rarest subtypes like polymorphous low-grade adenocarcinoma and oncocytic carcinoma are "struggling" to become clinically relevant entities in line with those occurring more frequently in salivary glands.
  • [MeSH-major] Adenocarcinoma / pathology. Biomarkers, Tumor / metabolism. Breast Neoplasms / pathology. Neoplasms, Complex and Mixed / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / pathology. Adenomyoepithelioma / metabolism. Adenomyoepithelioma / pathology. Breast Neoplasms, Male / metabolism. Breast Neoplasms, Male / pathology. Carcinoma, Acinar Cell / metabolism. Carcinoma, Acinar Cell / pathology. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / metabolism. Carcinoma, Mucoepidermoid / pathology. Female. Humans. Male. Receptor, ErbB-2 / metabolism. Receptors, Estrogen / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 20306833.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
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38. Leivo I, Jee KJ, Heikinheimo K, Laine M, Ollila J, Nagy B, Knuutila S: Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation. Cancer Genet Cytogenet; 2005 Jan 15;156(2):104-13
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  • [Title] Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation.
  • Gene expression profiles were studied in 13 cases of salivary gland carcinoma including mucoepidermoid carcinoma (MEC), acinic cell carcinoma (ACC), and salivary duct carcinoma (SDC) using a cDNA array.
  • The small number of similarly deregulated genes in these carcinoma entities suggests an extensive genetic variation between them.
  • This result agrees with the great histopathological diversity of different entities of salivary gland carcinoma.
  • Furthermore, diversity in gene expression between the carcinoma types was identified also by hierarchical clustering.
  • Each carcinoma entity was clustered together but MEC, SDC, and ACC were separated from each other.
  • In MEC, overexpressed genes included those of cell proliferation (IL-6 and SFN) and cell adhesion (SEMA3F and COL6A3), whereas many underexpressed genes were related to DNA modification (NTHL1 and RBBP4).
  • Apoptosis-related genes CASP10 and MMP11 were overexpressed in SDC, in accordance with the typical tumor necrosis seen in this entity.
  • An intermediate filament protein of basal epithelial cells, cytokeratin 14 (KRT14) was clearly differently expressed between the 3 types of carcinoma, and can be used as an aid in their differential diagnosis.
  • [MeSH-major] Epithelial Cells / pathology. Gene Expression Regulation, Neoplastic. Parotid Neoplasms / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. DNA Primers. Female. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction


39. Akrish S, Peled M, Ben-Izhak O, Nagler RM: Malignant salivary gland tumors and cyclo-oxygenase-2: a histopathological and immunohistochemical analysis with implications on histogenesis. Oral Oncol; 2009 Dec;45(12):1044-50
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  • [Title] Malignant salivary gland tumors and cyclo-oxygenase-2: a histopathological and immunohistochemical analysis with implications on histogenesis.
  • The classification system for malignant salivary gland tumors (MST) is largely dependent on its histogenesis.
  • Fifty six primary major and minor gland MST were stained with anti-cox-2 antibody and rated with a combined score that added a scale of intensity to the percentage of tumor cells that overexpressed the cox-2 protein.
  • Tumor types were segregated by morphology, histological features and proposed histogenesis.
  • Strong cox-2 overexpression was noted in all MST of proposed excretory duct origin: salivary duct carcinoma (100%), mucoepidermoid carcinoma (MEC) (92%), and adenocarcinoma nos (AdC nos) (83%).
  • Primary squamous cell carcinoma (PSCC) was the exception.
  • Negative expression was noted in all tumors of proposed intercalated duct origin (adenoid cystic carcinoma, basal cell adenocarcinoma and acinic cell carcinoma) with the exception of one case of polymorphous low grade adenocarcinoma.
  • Strong cox-2 overexpression was noted in the epidermoid cells of MEC, abluminal duct cells surrounding the duct-like structures and ductal cells of AdC nos and salivary duct carcinoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cyclooxygenase 2 / analysis. Salivary Gland Neoplasms / enzymology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19729335.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 1.14.99.1 / Cyclooxygenase 2
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40. Craver RD, Fonseca P, Carr R: Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a children's hospital. Pediatr Dev Pathol; 2010 Sep-Oct;13(5):348-53
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  • [Title] Pediatric epithelial salivary gland tumors: spectrum of histologies and cytogenetics at a children's hospital.
  • There are conflicting reports regarding the relative frequency of benign and malignant epithelial salivary gland tumors in children.
  • A retrospective 14 year review of epithelial salivary gland tumors encountered at a children's hospital identified 13 tumors: 12 PAs and 1 acinic cell carcinoma (ACC).
  • One tumor with ins(18;8)(q21.1;q12q22.2) had no PLAG1 staining, but stained with HMGA2.
  • [MeSH-major] Adenoma, Pleomorphic / genetics. Adenoma, Pleomorphic / pathology. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 20055685.001).
  • [ISSN] 1093-5266
  • [Journal-full-title] Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • [ISO-abbreviation] Pediatr. Dev. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / HMGA2 Protein; 0 / PLAG1 protein, human
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41. Vargas PA, Speight PM, Bingle CD, Barrett AW, Bingle L: Expression of PLUNC family members in benign and malignant salivary gland tumours. Oral Dis; 2008 Oct;14(7):613-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of PLUNC family members in benign and malignant salivary gland tumours.
  • OBJECTIVES: The aim of this study was to determine the expression of PLUNC proteins in benign and malignant salivary gland tumours and thus their potential use as diagnostic and / or prognostic tools.
  • MATERIALS AND METHODS: A tissue microarray was assembled from 64 salivary gland tumours including adenoid cystic carcinoma, carcinoma ex-pleomorphic adenoma, mucoepidermoid carcinoma, polymorphous low-grade adenocarcinoma, pleomorphic adenoma, acinic cell carcinoma, myoepithelial carcinoma and papillary cystadenocarcinoma.
  • CONCLUSIONS: Intense expression of two PLUNC proteins in mucous cells and mucin plugs of mucoepidermoid carcinoma and papillary cystadenocarcinoma indicate that they could be used as additional diagnostic tools in some equivocal cases, but further studies are needed to understand the biological processes involved in PLUNC expression.
  • [MeSH-major] Biomarkers, Tumor. Carcinoma, Mucoepidermoid / metabolism. Cystadenocarcinoma, Papillary / metabolism. Glycoproteins / biosynthesis. Phosphoproteins / biosynthesis. Salivary Gland Neoplasms / metabolism

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  • (PMID = 18221458.001).
  • [ISSN] 1601-0825
  • [Journal-full-title] Oral diseases
  • [ISO-abbreviation] Oral Dis
  • [Language] eng
  • [Grant] United Kingdom / Wellcome Trust / / WT076491; United Kingdom / Wellcome Trust / /
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / BPIFA1 protein, human; 0 / Biomarkers, Tumor; 0 / Glycoproteins; 0 / Phosphoproteins
  • [Other-IDs] NLM/ PMC2853704; NLM/ UKMS29166
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42. Shigeishi H, Mizuta K, Higashikawa K, Yoneda S, Ono S, Kamata N: Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors. Oral Oncol; 2005 Aug;41(7):716-22
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  • [Title] Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors.
  • We examined the expression of Centromere protein F (CENP-F) mRNA in 26 human salivary gland tumors (seven pleomorphic adenomas, three Warthin tumors, seven mucoepidermoid carcinomas, four adenoid cystic carcinomas, four acinic cell carcinomas and one malignant myoepithelioma) and four normal submandibular glands using the real time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
  • These results indicate that human CENP-F mRNA is closely linked to the increased or abnormal cell proliferation in malignant conditions.
  • [MeSH-major] Adenoma / genetics. Chromosomal Proteins, Non-Histone / genetics. Gene Expression Regulation, Neoplastic / genetics. Salivary Gland Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cell Proliferation. Female. Humans. Male. Microfilament Proteins. Middle Aged. RNA, Messenger / metabolism. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Submandibular Gland / metabolism

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  • (PMID = 15927522.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Chromosomal Proteins, Non-Histone; 0 / Microfilament Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / centromere protein F
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43. Whitt JC, Schafer DR, Callihan MD: Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Head Neck Pathol; 2008 Mar;2(1):41-8
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  • [Title] Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth.
  • Salivary gland tumors usually occur as single lesions.
  • To have more than one tumor is unusual.
  • We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mouth at age 63 years.
  • There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature.
  • Bilateral acinic cell adenocarcinoma was the most frequent combination of multiple salivary gland malignancy, accounting for 14 cases (10 synchronous and four metachronous).
  • All involved the parotid glands bilaterally with the exception of one case that involved parotid and submandibular gland.
  • Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Mouth Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 20614341.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807610
  • [Keywords] NOTNLM ; Metachronous neoplasms / Multiple malignant salivary gland neoplasms / Salivary gland neoplasms / Salivary gland tumors / Synchronous neoplasms
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44. van der Schroeff MP, Terhaard CH, Wieringa MH, Datema FR, Baatenburg de Jong RJ: Cytology and histology have limited added value in prognostic models for salivary gland carcinomas. Oral Oncol; 2010 Sep;46(9):662-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytology and histology have limited added value in prognostic models for salivary gland carcinomas.
  • Univariate analyses on malignant salivary gland tumors report a strong relation of histological subtypes and prognosis.
  • In order to study the prognostic value of cytology and histology in salivary carcinoma we performed multivariate analyses on 666 newly diagnosed patients.
  • In multivariate analyses sex, tumor size, N- and M-staging, localization, comorbidity, skin involvement and pain were independent predictors of survival.
  • Histology was an independent prognostic factor, mainly because acinic cell carcinoma acted differently from the other histological subtypes.
  • The added prognostic value of cytology and/or histology factors in salivary carcinoma is limited, largely due to the combined prognostic value of other prognostic factors such as tumor size, N- and M-classification and comorbidity.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20637682.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
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45. Luukkaa H, Klemi P, Hirsimäki P, Vahlberg T, Kivisaari A, Kähäri VM, Grénman R: Matrix metalloproteinase (MMP)-7 in salivary gland cancer. Acta Oncol; 2010;49(1):85-90
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  • [Title] Matrix metalloproteinase (MMP)-7 in salivary gland cancer.
  • The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-year survival of the SGC patients.
  • By age-adjusted analysis lower staining intensity was associated with worse overall survival of patients with acinic cell carcinoma (p = 0.047, HR 6.5, 95% Cl 1.0-41.7) and in mucoepidermoid carcinoma (p = 0.010, HR 9.3, 95% CI 1.7-50.0).
  • Low staining intensity was also associated with worse disease-specific survival of patients with acinic cell carcinoma (0-1 vs. 2-3; p = 0.047, HR 13.7, 1.0-200.0).
  • CONCLUSIONS: MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Mucoepidermoid / metabolism. Matrix Metalloproteinase 7 / biosynthesis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Ductal / metabolism. Carcinoma, Ductal / mortality. Carcinoma, Ductal / pathology. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 19929564.001).
  • [ISSN] 1651-226X
  • [Journal-full-title] Acta oncologica (Stockholm, Sweden)
  • [ISO-abbreviation] Acta Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.23 / Matrix Metalloproteinase 7
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46. Luukkaa H, Klemi P, Hirsimäki P, Vahlberg T, Kivisaari A, Kähäri VM, Grénman R: Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer. Acta Otolaryngol; 2008 Apr;128(4):482-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer.
  • CONCLUSIONS: In the current study matrix metalloproteinases (MMPs)-9 and -13 were associated with the prognosis in salivary gland cancer (SGC), indicating that they contribute to the progression and invasion of these malignant tumours.
  • High MMP-13 intensity (2+3 vs 1; p=0.05), percentage (2 vs 1; p=0.03) and index (3 vs 1; p=0.02) were associated with poor survival in acinic cell carcinoma.
  • However, high MMP-9 index in adenoid cystic carcinoma (p=0.06) and the percentage of positively staining cells in salivary duct carcinoma patients (p=0.05) was associated with poor survival.
  • [MeSH-major] Carcinoma / enzymology. Matrix Metalloproteinase 1 / metabolism. Matrix Metalloproteinase 13 / metabolism. Matrix Metalloproteinase 9 / metabolism. Salivary Gland Neoplasms / enzymology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Female. Finland / epidemiology. Follow-Up Studies. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate / trends. Time Factors

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  • (PMID = 18368586.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.24.- / Matrix Metalloproteinase 13; EC 3.4.24.35 / Matrix Metalloproteinase 9; EC 3.4.24.7 / Matrix Metalloproteinase 1
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47. Schwarz S, Ettl T, Kleinsasser N, Hartmann A, Reichert TE, Driemel O: Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors. Oral Oncol; 2008 Jun;44(6):563-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Loss of Maspin expression is a negative prognostic factor in common salivary gland tumors.
  • Maspin, a 42kDa protein, belongs to the serine protease inhibitor (serpin) family and is suggested to have inhibitory effects on tumor-induced angiogenesis, tumor cell motility, invasion and metastasis and influences prognosis of tumor patients.
  • The aim of the study was to analyze Maspin expression in salivary gland cancer as well as its prognostic impact on survival in comparison to clinical parameters.
  • Immunohistochemical staining was carried out in 73 cases of salivary gland malignancies.
  • High proportions of Maspin expression were observed in adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas ex pleomorphic adenoma, low proportions were seen in salivary duct carcinomas.
  • Acinic cell carcinomas did not show any Maspin expression.
  • Analysis of the prognostic impact of Maspin expression was restricted to salivary gland carcinoma types of intermediate malignancy grade (adenoid cystic carcinoma, mucoepidermoid carcinoma and carcinoma ex pleomorphic adenoma).
  • For these tumors, univariate analyses revealed that T-stage (p=0.025), age70 (p=0.0065), loss of Maspin (p=0.0016) and presence of residual tumor (p<0.001) correlated with poor prognosis.
  • Moreover, negative Maspin staining was associated with lymph node metastasis and residual tumor.
  • According to these findings, Maspin might be useful as a new prognostic marker in adenoid cystic carcinoma and in salivary gland carcinomas with intermediate grade of malignancy where grading systems are still under debate.
  • [MeSH-major] Carcinoma, Mucoepidermoid / metabolism. Salivary Gland Neoplasms / metabolism. Serpins / metabolism. Tumor Suppressor Proteins / metabolism
  • [MeSH-minor] Adenoma, Pleomorphic / metabolism. Adenoma, Pleomorphic / mortality. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Adenoid Cystic / mortality. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Prognosis. Serine Proteinase Inhibitors / pharmacology. Survival Rate. Young Adult

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  • (PMID = 17936671.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / SERPIN-B5; 0 / Serine Proteinase Inhibitors; 0 / Serpins; 0 / Tumor Suppressor Proteins
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48. Daniel E, McGuirt WF Sr: Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience. Am J Otolaryngol; 2005 Mar-Apr;26(2):96-100
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  • [Title] Neck masses secondary to heterotopic salivary gland tissue: a 25-year experience.
  • OBJECTIVES: The aim of this study is to review salivary tumors arising from heterotopic salivary inclusions in the periparotid and cervical lymph nodal tissues over a 25-year span.
  • METHODS: A retrospective chart review revealed 24 patients with asymptomatic neck masses treated between 1976 and 2001, whose pathology demonstrated heterotopic salivary tissue or neoplasms arising from heterotopic salivary tissue.
  • RESULTS: Nine cases were benign periparotid lymph nodes with heterotopic salivary inclusions, 3 of which had multimodal involvement.
  • Fifteen cases of heterotopic salivary tumors were identified.
  • The benign tumors were predominantly Warthin's tumor (8) with 1 pleomorphic adenoma.
  • Malignant tumors included mucoepidermoid (3), acinic cell (2), and adenocarcinoma (1).
  • Among the 15 tumor patients, follow-up ranged from 1 month to 17 years.
  • CONCLUSIONS: Heterotopic salivary tissue in periparotid and upper cervical nodes is a more common occurrence than historically recognized.
  • Tumorigenic changes arise from heterotopic nodal inclusions, and although infrequent, should be considered in the differential diagnosis for isolated neck/periparotid masses and parotid Warthin's tumor.
  • Suggested management, after a thorough clinical exam/needle aspiration biopsy, includes an imaging survey of the parotid gland and neck lymphatics with an appropriate resection to include a simple excision, parotidectomy, neck dissection, and/or irradiation as indicated.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma, Pleomorphic / pathology. Choristoma / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands

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  • (PMID = 15742261.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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49. Darling MR, Tsai S, Jackson-Boeters L, Daley TD, Diamandis EP: Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors. Int J Biol Markers; 2006 Oct-Dec;21(4):201-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors.
  • The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus.
  • Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland.
  • The aim of this study was to determine whether hK3 and hK5 are expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues.
  • Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas and adenocarcinomas not otherwise specified of both minor and major salivary glands were examined.
  • The results of this study indicate that most salivary gland tumors do not show high levels of expression of hK5.
  • Staining was most prominent in keratinizing epithelia in pleomorphic adenomas. hK3 is not expressed in salivary gland tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Kallikreins / analysis. Prostate-Specific Antigen / analysis. Salivary Gland Neoplasms / chemistry

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  • (PMID = 17177156.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 3.4.21.- / Kallikreins; EC 3.4.21.- / kallikrein 5, human; EC 3.4.21.77 / Prostate-Specific Antigen
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50. Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM: Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours. J Oral Pathol Med; 2008 May;37(5):309-18
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  • [Title] Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours.
  • The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour.
  • There were 13 adenoid cystic carcinomas (ACC), 10 carcinoma ex pleomorphic adenomas (CEPA), 10 mucoepidermoid carcinomas (MEC), 10 polymorphous low-grade adenocarcinomas (PLGA), 10 pleomorphic adenomas (PA) and nine acinic cell carcinomas (AcCC).
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Cell Cycle Proteins / biosynthesis. Ki-67 Antigen / biosynthesis. Nuclear Proteins / biosynthesis. Salivary Gland Neoplasms / metabolism
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / metabolism. Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / metabolism. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Acinar Cell / diagnosis. Carcinoma, Acinar Cell / metabolism. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / metabolism. Cell Proliferation. Diagnosis, Differential. Female. Geminin. Humans. Immunoenzyme Techniques. Male. Microarray Analysis. Middle Aged. Minichromosome Maintenance Complex Component 2. Neoplasm Proteins / biosynthesis

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  • (PMID = 18248354.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / GMNN protein, human; 0 / Geminin; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
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51. Daneshbod Y, Daneshbod K, Khademi B: Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited. Acta Cytol; 2009 Jan-Feb;53(1):53-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic difficulties in the interpretation of fine needle aspirate samples in salivary lesions: diagnostic pitfalls revisited.
  • OBJECTIVE: To present our experience in diagnostic errors and pitfalls on aspiration cytology of salivary region in a high volume of cases.
  • STUDY DESIGN: In a retrospective review of cytology files of a head and neck referral center from 1990 to 2005, the false positive and false negative interpretations on fine needle aspiration (FNA) of salivary lesions were retrieved.
  • RESULTS: Of a total of 1,040 salivary FNA samples, 376 cases had a final histologic diagnosis with interpretations of benign or malignant.
  • The most common false negative cases were acinic cell carcinoma, epithelial myoepithelial carcinoma, adenoid cystic carcinoma and basal cell adenocarcinoma.
  • Benign cases with false positive diagnosis were Warthin tumor and pleomorphic adenoma.
  • CONCLUSION: Knowledge of cytologic overlaps and pitfalls on salivary gland FNA, as well as clinical and radiologic features, may help clinicians arrive at the appropriate diagnosis and reduce false interpretations.
  • [MeSH-major] Salivary Gland Neoplasms / diagnosis. Salivary Glands / pathology

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  • (PMID = 19248555.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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52. Chen AM, Granchi PJ, Garcia J, Bucci MK, Fu KK, Eisele DW: Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy. Int J Radiat Oncol Biol Phys; 2007 Mar 15;67(4):982-7
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  • [Title] Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy.
  • PURPOSE: To determine factors predictive of local-regional recurrence (LRR) after surgery alone for carcinomas of the major salivary glands in an attempt to evaluate the potential role of postoperative radiation therapy.
  • METHODS AND MATERIALS: Between 1960 and 2004, 207 patients with carcinomas of the major salivary glands were treated with definitive surgery without postoperative radiation therapy.
  • Histology was: 67 mucoepidermoid (32%), 50 adenoid cystic (24%), 34 acinic cell (16%), 23 malignant mixed (11%), 16 adenocarcinoma (8%), 6 oncocytic (3%), 6 myoepithelial (3%), and 5 other (2%).
  • CONCLUSION: Lymph node metastasis, high tumor grade, positive margins, and T3-4 stage predict for significant rates of LRR after surgery for carcinomas of the major salivary glands.
  • [MeSH-major] Carcinoma / secondary. Carcinoma / surgery. Neoplasm Recurrence, Local. Salivary Gland Neoplasms / pathology. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Analysis of Variance. Female. Humans. Male. Middle Aged. Neoplasm Staging. Proportional Hazards Models. Radiotherapy, Adjuvant. Survival Analysis

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  • (PMID = 17241753.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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53. Habermann CR, Arndt C, Graessner J, Diestel L, Petersen KU, Reitmeier F, Ussmueller JO, Adam G, Jaehne M: Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible? AJNR Am J Neuroradiol; 2009 Mar;30(3):591-6
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  • [Title] Diffusion-weighted echo-planar MR imaging of primary parotid gland tumors: is a prediction of different histologic subtypes possible?
  • BACKGROUND AND PURPOSE: Our aim was to determine the value of echo-planar diffusion-weighted MR imaging (epiDWI) in differentiating various types of primary parotid gland tumors.
  • MATERIALS AND METHODS: One hundred forty-nine consecutive patients with suspected tumors of the parotid gland were examined with an epiDWI sequence by using a 1.5T unit.
  • RESULTS: In 136 patients, a primary parotid gland tumor was confirmed by histology.
  • ADC values of Warthin tumors were different from those of myoepithelial adenomas, lipomas, and salivary duct carcinomas (P < .001, 0.013, and .037, respectively).
  • Mucoepidermoid carcinomas, acinic cell carcinomas, and basal cell adenocarcinomas were not differentiable from Warthin tumors (P = .094, .396, and .604, respectively).
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Echo-Planar Imaging. Myoepithelioma / pathology. Parotid Gland / pathology
  • [MeSH-minor] Adenolymphoma / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Mucoepidermoid / pathology. Diagnosis, Differential. Female. Humans. Lipoma / pathology. Male. Middle Aged. Prospective Studies. Salivary Gland Neoplasms / pathology. Young Adult

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  • (PMID = 19131405.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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54. Miliauskas JR, Hunt JL: Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review. Head Neck Pathol; 2008 Dec;2(4):339-42
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  • [Title] Primary unilateral multifocal pleomorphic adenoma of the parotid gland: molecular assessment and literature review.
  • Multiple separate tumors developing in a single salivary gland is rare in previously untreated patients.
  • Tumors that can be multicentric include Warthin tumor, oncocytoma, basal cell adenoma and acinic cell carcinoma.
  • [MeSH-minor] Aged. Clone Cells. DNA, Neoplasm / analysis. Female. Humans

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  • [Cites] Laryngorhinootologie. 2007 Jun;86(6):448-50 [17219338.001]
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  • (PMID = 20614306.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2807582
  • [Keywords] NOTNLM ; Multifocal / Parotid gland / Pleomorphic adenoma
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55. Chahwala Q, Siddaraju N, Singh N, Goneppanavar M, Basu D: Fine needle aspiration cytology of oncocytic lipoadenoma of the parotid gland: report of a rare case. Acta Cytol; 2009 Jul-Aug;53(4):437-9

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  • [Title] Fine needle aspiration cytology of oncocytic lipoadenoma of the parotid gland: report of a rare case.
  • BACKGROUND: Oncocytic lipoadenoma is an uncommon benign salivary gland tumor.
  • CASE: A 50-year-old woman presented with a slow-growing swelling in the left parotid region that was clinically interpreted as a soft tissue tumor, with a differential of neurofibroma/lipoma.
  • A remote possibility of acinic cell carcinoma with oncocytic features was also suggested.
  • However, histopathologic examination showed it to be an oncocytic lipoadenoma, a tumor we were unaware of at the time of cytodiagnosis.
  • CONCLUSION: Both cytopathologists and histopathologists need to be aware of oncocytic lipoadenoma of the salivary gland in order to diagnose it precisely.

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  • (PMID = 19697732.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Kawahara A, Harada H, Mihashi H, Akiba J, Kage M: Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review. Diagn Cytopathol; 2010 May;38(5):377-81

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review.
  • Cystadenocarcinoma is a rare malignant tumor, with an estimated incidence of 2% of malignant salivary gland tumors.
  • A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years.
  • Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid.
  • Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm.
  • The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these findings on FNAC.
  • Histologically, the tumor was not encapsulated, but formed large cystic spaces against a background of fibrous connective tissue.
  • The tumor cells in the cystic dilated duct showed papillary structures, which were continuous with the lining cuboidal cells.
  • As tumor cells with a small vacuolated, soap-bubble appearance of the cytoplasm are common findings of both cystadenocarcinoma and ACC-PCV, they are of little use for differentiation; however, they are so characteristic that the majority of benign salivary gland lesions with cystic structures can be excluded, if enough attention is paid.
  • [MeSH-major] Cyst Fluid / cytology. Cystadenocarcinoma / diagnosis. Cystadenocarcinoma / pathology. Diagnostic Errors. Parotid Gland / pathology. Parotid Neoplasms / diagnosis. Parotid Neoplasms / pathology

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  • (PMID = 19927358.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 110
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57. Lima RA, Tavares MR, Dias FL, Kligerman J, Nascimento MF, Barbosa MM, Cernea CR, Soares JR, Santos IC, Salviano S: Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg; 2005 Nov;133(5):702-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical prognostic factors in malignant parotid gland tumors.
  • RESULTS: Forty patients had mucoepidermoid carcinoma, 18 patients adenocarcinoma NOS, 18 patients acinic cell carcinoma, 15 patients adenoid cystic carcinoma, 11 patients malignant mixed tumor, 11 patients salivary duct carcinoma, and 13 patients other pathology.
  • CONCLUSION: The grade of the tumor and stage were the most important prognostic factor.
  • [MeSH-major] Adenocarcinoma / mortality. Adenocarcinoma / therapy. Neoplasm Invasiveness / pathology. Parotid Neoplasms / mortality. Parotid Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Child. Child, Preschool. Cohort Studies. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Middle Aged. Multivariate Analysis. Neck Dissection / methods. Neoplasm Staging. Parotid Gland / radiation effects. Parotid Gland / surgery. Probability. Proportional Hazards Models. Radiotherapy, Adjuvant. Retrospective Studies. Risk Assessment. Sex Factors. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 16274796.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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58. Cheuk DK, Shek TW, Chan GC, Lau YL, Ha SY, Chiang AK: Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; 2008 Mar;50(3):636-9
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  • [Title] Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia.
  • Salivary gland tumors account for about 6% of the second cancers.
  • The majority of these are mucoepidermoid carcinomas (MEC) of the parotid gland.
  • We report the clinical and pathological features of a rarer histological type, acinic cell carcinoma (ACC), in a childhood acute lymphoblastic leukemia (ALL) survivor.
  • The behavior of secondary ACC appears similar to primary tumor and similar treatment may be adopted.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Carcinoma, Acinar Cell / etiology. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology. Parotid Neoplasms / etiology. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy. Whole-Body Irradiation / adverse effects
  • [MeSH-minor] 6-Mercaptopurine / administration & dosage. 6-Mercaptopurine / adverse effects. Adenoma, Sweat Gland / etiology. Adenoma, Sweat Gland / surgery. Asparaginase / administration & dosage. Asparaginase / adverse effects. Child, Preschool. Combined Modality Therapy / adverse effects. Cyclophosphamide / administration & dosage. Cyclophosphamide / adverse effects. Cytarabine / administration & dosage. Cytarabine / adverse effects. Daunorubicin / administration & dosage. Daunorubicin / adverse effects. Epirubicin / administration & dosage. Epirubicin / adverse effects. Etoposide / administration & dosage. Etoposide / adverse effects. Follow-Up Studies. Humans. Male. Methotrexate / administration & dosage. Methotrexate / adverse effects. Prednisolone / administration & dosage. Prednisolone / adverse effects. Recurrence. Remission Induction. Survivors. Sweat Gland Neoplasms / etiology. Sweat Gland Neoplasms / surgery. Vincristine / administration & dosage. Vincristine / adverse effects

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 16865683.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 04079A1RDZ / Cytarabine; 3Z8479ZZ5X / Epirubicin; 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 8N3DW7272P / Cyclophosphamide; 9PHQ9Y1OLM / Prednisolone; E7WED276I5 / 6-Mercaptopurine; EC 3.5.1.1 / Asparaginase; YL5FZ2Y5U1 / Methotrexate; ZS7284E0ZP / Daunorubicin; UKALL X protocol
  • [Number-of-references] 17
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59. Vageli D, Sourvinos G, Ioannou M, Koukoulis GK, Spandidos DA: High-risk human papillomavirus (HPV) in parotid lesions. Int J Biol Markers; 2007 Oct-Dec;22(4):239-44
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  • Although several studies have reported that oropharyngeal infection with HPV may predispose to tumorigenesis, little is known about the etiological factors of salivary gland tumors and the presence of HPV.
  • We studied 9 parotid lesions for HPV infection including an oncocytoma, an acinic cell carcinoma, a high-grade adenocarcinoma, a low-grade polymorphous adenocarcinoma, a Warthin's tumor and 2 pleomorphic adenomas, a lymphoepithelial cyst and a lipoma of the parotid gland.
  • High viral load of highrisk genotypes of HPV was found in the oncocytoma, in one of the pleomorphic adenomas, and in the Warthin's tumor.
  • Finally, in situ PCR indicated that HPV16 amplification occurred in the salivary gland tumors.
  • [MeSH-major] Papillomaviridae / metabolism. Papillomavirus Infections / virology. Parotid Gland / pathology. Parotid Neoplasms / virology. Salivary Gland Neoplasms / virology

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  • [CommentIn] Int J Biol Markers. 2011 Oct-Dec;26(4):278-80 [22180174.001]
  • (PMID = 18161653.001).
  • [ISSN] 0393-6155
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / DNA Probes, HPV
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60. Zhang S, Bao R, Abreo F: Papillary oncocytic cystadenoma of the parotid glands: a report of 2 cases with varied cytologic features. Acta Cytol; 2009 Jul-Aug;53(4):445-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Papillary cystadenoma is a rare salivary gland neoplasm, and oncocytic change can be focal or marked.
  • Papillary oncocytic cystadenoma has been reported mainly in the minor salivary glands and occasionally in the parotid glands.
  • CASES: A 26-year-old female presented with a 2.4-cm, cystic right parotid gland mass present for 4 months.
  • The diagnosis ofa neoplasm was rendered and excisional biopsy recommended.
  • Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular, cystic, oncocytic neoplasm with variable papillary projections.
  • Oncocytic neoplasm was diagnosed during intraoperative consultation, and final surgical histology showed a unilocular cystic lesion with multiple papillary fronds lined with oncocytic cells and focal metaplastic squamous cells.
  • Warthin's tumor, oncocytoma, intraductal papilloma and acinic cell carcinoma may arise in the differential diagnosis.
  • In cases with extensive necrotic debris and metaplastic squamous cells, branchial cyst and cystic metastatic squamous carcinoma may also need to be considered.

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  • (PMID = 19697734.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Luna MA: Sinonasal tubulopapillary low-grade adenocarcinoma: a specific diagnosis or just another seromucous adenocarcinoma? Adv Anat Pathol; 2005 May;12(3):109-15
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histopathologically, sinonasal adenocarcinomas fall into four categories: the intestinal type, the conventional salivary gland type (eg, adenoid cystic carcinoma, acinic cell carcinoma), the seromucous type, and the low-grade not otherwise specified type.
  • In this commentary, the histologic features of this type of tumor are compared with those of the other types of sinonasal adenocarcinoma.
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Nasal Cavity / pathology. Neoplasm Recurrence, Local

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  • [CommentOn] Virchows Arch. 2003 Aug;443(2):152-8 [12827515.001]
  • (PMID = 15900111.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Comment; Journal Article
  • [Publication-country] United States
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62. Daneshbod Y, Negahban S, Khademi B: Re: acinic cell carcinoma of salivary gland with massive deposits of globular amyloid. Int J Surg Pathol; 2009 Jun;17(3):276-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Re: acinic cell carcinoma of salivary gland with massive deposits of globular amyloid.
  • [MeSH-major] Amyloid / metabolism. Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 19321535.001).
  • [ISSN] 1066-8969
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Amyloid
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63. Thompson LD: Salivary gland acinic cell carcinoma. Ear Nose Throat J; 2010 Nov;89(11):530-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland acinic cell carcinoma.
  • [MeSH-major] Carcinoma, Acinar Cell / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 21086276.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Hall DA, Pu RT: Acinic cell carcinoma of the salivary gland: a continuing medical education case. Diagn Cytopathol; 2008 Jun;36(6):379-85; quiz 386-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Acinic cell carcinoma of the salivary gland: a continuing medical education case.
  • [MeSH-major] Carcinoma, Acinar Cell. Salivary Gland Neoplasms
  • [MeSH-minor] Aged. Diagnosis, Differential. Education, Medical, Continuing. Female. Humans. Prognosis. Salivary Glands / pathology

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  • (PMID = 18478605.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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