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1. Hwang SW, Kang JH, Jung SY, Choi JH, Seo JK, Lee D, Sung HS: Vitiligo Coexistent with Nevus Depigmentosus: This Was Treated with Narrow-Band UVB and These Lesions Were Followed Using the Mexameter®, a Pigment-Measuring Device. Ann Dermatol; 2010 Nov;22(4):482-5
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  • [Title] Vitiligo Coexistent with Nevus Depigmentosus: This Was Treated with Narrow-Band UVB and These Lesions Were Followed Using the Mexameter®, a Pigment-Measuring Device.
  • Nevus depigmentosus (ND) is a congenital, non-progressive, hypopigmented lesion that is usually stable throughout an affected individual's lifetime.

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  • (PMID = 21165227.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2991734
  • [Keywords] NOTNLM ; Narrow-band UVB / Nevus depigmentosus / Vitiligo
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2. Shih IH, Lin JY, Chen CH, Hong HS: A birthmark survey in 500 newborns: clinical observation in two northern Taiwan medical center nurseries. Chang Gung Med J; 2007 May-Jun;30(3):220-5
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  • RESULTS: The most common pigmentary birthmark was the Mongolian spot (61.6%), followed by congenital melanocytic nevi (0.6%), café-au-lait spots (0.4%), and nevi depigmentosus (0.4%).
  • The two nevus depigmentosus cases were isolated types and neither of these were distributed along the Blaschko lines.


3. Khandpur S, Sumanth M K: Systematized nevus depigmentosus. Indian Pediatr; 2005 Oct;42(10):1046-7
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  • [Title] Systematized nevus depigmentosus.
  • [MeSH-major] Hypopigmentation / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 16269846.001).
  • [ISSN] 0019-6061
  • [Journal-full-title] Indian pediatrics
  • [ISO-abbreviation] Indian Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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4. Bardazzi F, Balestri R, Antonucci A, Spadola G: Lentigines within nevus depigmentosus: a rare collateral effect of UVB therapy? Pediatr Dermatol; 2008 Mar-Apr;25(2):272-4
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  • [Title] Lentigines within nevus depigmentosus: a rare collateral effect of UVB therapy?
  • Nevus depigmentosus is an uncommon hypopigmented macule or patch that is congenital and stable in its relative size and distribution throughout life; it occurs sporadically and may be localized, segmental or, less often, systematized.
  • We report the case of a 17-year-old girl with a segmental achromic nevus of the left leg and a patch on the lower back with late age of onset who developed lentigines after prolonged intense ultraviolet B exposure as a consequence of an incorrect diagnosis of segmental vitiligo.
  • [MeSH-major] Diagnostic Errors. Lentigo / etiology. Nevus / diagnosis. Ultraviolet Therapy / adverse effects. Vitiligo / diagnosis. Vitiligo / radiotherapy

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  • (PMID = 18429802.001).
  • [ISSN] 1525-1470
  • [Journal-full-title] Pediatric dermatology
  • [ISO-abbreviation] Pediatr Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. van Geel N, Wallaeys E, Goh BK, De Mil M, Lambert J: Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus. Br J Dermatol; 2010 Dec;163(6):1186-93
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  • [Title] Long-term results of noncultured epidermal cellular grafting in vitiligo, halo naevi, piebaldism and naevus depigmentosus.
  • OBJECTIVES: To evaluate the long-term results of the noncultured epidermal cellular grafting technique in patients with different types of leucoderma, including segmental vitiligo (n = 33), generalized vitiligo (n = 33), mixed vitiligo (n = 6), halo naevi (n = 11), piebaldism (n = 3) and naevus depigmentosus (n = 1).
  • Best results were obtained in segmental vitiligo, halo naevi and piebaldism, whereas results in generalized or mixed vitiligo were inferior.
  • [MeSH-major] Cell Transplantation / methods. Epidermis / cytology. Nevus / surgery. Piebaldism / surgery. Skin Neoplasms / surgery. Vitiligo / surgery


6. Xu AE, Huang B, Li YW, Wang P, Shen H: Clinical, histopathological and ultrastructural characteristics of naevus depigmentosus. Clin Exp Dermatol; 2008 Jul;33(4):400-5
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  • [Title] Clinical, histopathological and ultrastructural characteristics of naevus depigmentosus.
  • BACKGROUND: Naevus depigmentosus (ND) is a congenital, nonfamilial, well-circumscribed, uniformly hypopigmented macule, the relative size and distribution of which is stable throughout life.
  • [MeSH-major] Melanocytes / pathology. Nevus, Pigmented / pathology. Skin / pathology. Skin Neoplasms / pathology. Vitiligo / pathology

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  • (PMID = 18355354.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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7. Afsar FS, Aktas S, Ortac R: Becker's naevus and segmental naevus depigmentosus: an example of twin spotting? Australas J Dermatol; 2007 Nov;48(4):224-6
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  • [Title] Becker's naevus and segmental naevus depigmentosus: an example of twin spotting?
  • A 12-year-old girl presented with a 1-year history of a Becker's naevus involving the right posterior thigh and gluteal area.
  • In addition, three hypopigmented macules of naevus depigmentosus distributed in a segmental pattern on the medial aspect of the right posterior thigh had been present since birth.
  • [MeSH-major] Hypopigmentation / pathology. Nevus / pathology. Skin Neoplasms / pathology

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  • (PMID = 17956480.001).
  • [ISSN] 0004-8380
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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8. Xiang W, Xu A, Xu J, Bi Z, Shang Y, Ren Q: In vivo confocal laser scanning microscopy of hypopigmented macules: a preliminary comparison of confocal images in vitiligo, nevus depigmentosus and postinflammatory hypopigmentation. Lasers Med Sci; 2010 Jul;25(4):551-8
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  • [Title] In vivo confocal laser scanning microscopy of hypopigmented macules: a preliminary comparison of confocal images in vitiligo, nevus depigmentosus and postinflammatory hypopigmentation.
  • Our purpose was to evaluate CLSM features for non-invasive imaging of vitiligo, nevus depigmentosus and postinflammatory hypopigmentation in vivo.
  • Although, in 20 of 20 patients (100%) with nevus depigmentosus, the dermal papillary rings lost their integrity and the content of melanin decreased obviously, there must have been melanin in the dermal papillary rings during its development in all patients.
  • The content of melanin and dermal papillary rings in postinflammatory hypopigmentation probably depend on the depth and site of the inflammation; moreover, melanophages were observed in postinflammatory hypopigmentation but did not exist in vitiligo and nevus depigmentosus.
  • In addition, the content of melanin and dermal papillary rings in adjacent normal appearing skin showed changes in the active phase of vitiligo but showed no changes in any of the patients in the stable phases of vitiligo, nevus depigmentosus and postinflammatory hypopigmentation.
  • CLSM may be useful to discriminate vitiligo, postinflammatory hypopigmentation and nevus depigmentosus in a non-invasive fashion.
  • [MeSH-major] Hypopigmentation / pathology. Microscopy, Confocal. Nevus / pathology. Skin Neoplasms / pathology. Vitiligo / pathology


9. Park ES, Na JI, Kim SO, Huh CH, Youn SW, Park KC: Application of a pigment measuring device--Mexameter--for the differential diagnosis of vitiligo and nevus depigmentosus. Skin Res Technol; 2006 Nov;12(4):298-302
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  • [Title] Application of a pigment measuring device--Mexameter--for the differential diagnosis of vitiligo and nevus depigmentosus.
  • BACKGROUND/PURPOSE: Vitiligo and nevus depigmentosus (ND) present similar hypopigmented macules with significantly different prognoses.
  • [MeSH-major] Dermatology / instrumentation. Diagnostic Techniques and Procedures / instrumentation. Hypopigmentation / diagnosis. Nevus / diagnosis. Skin Pigmentation. Vitiligo / diagnosis


10. Kim SK, Kang HY, Lee ES, Kim YC: Clinical and histopathologic characteristics of nevus depigmentosus. J Am Acad Dermatol; 2006 Sep;55(3):423-8
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  • [Title] Clinical and histopathologic characteristics of nevus depigmentosus.
  • BACKGROUND: Nevus depigmentosus (ND) is known to be a rare congenital, nonprogressive disorder characterized by a hypopigmented lesion that remains stable over time.
  • [MeSH-major] Hypopigmentation / metabolism. Hypopigmentation / pathology. Nevus / metabolism. Nevus / pathology

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  • (PMID = 16908347.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Melanins
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11. In SI, Yi SW, Kang HY, Lee ES, Sohn S, Kim YC: Clinical and histopathological characteristics of pityriasis alba. Clin Exp Dermatol; 2009 Jul;34(5):591-7
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  • BACKGROUND: Pityriasis alba (PA) is a skin disorder characterized by asymptomatic, variably hypopigmented, slightly scaling patches with indistinct margins.
  • It is sometimes difficult to clinically differentiate PA from other hypopigmented disorders such as naevus depigmentosus.

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  • [ErratumIn] Clin Exp Dermatol. 2009 Aug;34(6):751
  • (PMID = 19094127.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Melanins
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12. Kim YC, Kim YJ, Kang HY, Sohn S, Lee ES: Histopathologic features in vitiligo. Am J Dermatopathol; 2008 Apr;30(2):112-6
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  • Nevus depigmentosus is a congenital disorder characterized by a nonprogressive hypopigmented lesion, which may not be apparent at birth.
  • Thus, it is sometimes difficult to differentiate vitiligo from nevus depigmentosus only by clinical features.
  • We compared them with 30 cases of nevus depigmentosus.
  • The ratio of pigmented area to epidermal area was 0.06% in vitiligo, whereas 17% in perilesional normal skin and 8.9% in nevus depigmentosus.
  • The number of melanocytes was also decreased in nevus depigmentosus but not as much as in vitiligo.

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  • (PMID = 18360112.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Melanins
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13. Shields CL, Furuta M, Mashayekhi A, Berman EL, Zahler JD, Hoberman DM, Dinh DH, Shields JA: Clinical spectrum of choroidal nevi based on age at presentation in 3422 consecutive eyes. Ophthalmology; 2008 Mar;115(3):546-552.e2
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  • [Title] Clinical spectrum of choroidal nevi based on age at presentation in 3422 consecutive eyes.
  • PURPOSE: To evaluate the clinical features of choroidal nevi based on patient age at presentation and to investigate features of the nevi that are predictive of patient symptoms.
  • MAIN OUTCOME MEASURES: Nevus features as related to patient age group at diagnosis (young [< or =20 years], mid-adult [21-50 years], older adult [>50 years]) and factors predictive of patient symptoms secondary to the nevus.
  • RESULTS: Of the 3422 eyes with choroidal nevus, 63 (2%) were in young patients, 795 (23%) in mid-adults, and 2564 (75%) in older adults.
  • The following factors showed no substantial increase or decrease by age category (young, mid-adult, older adult) at presentation: symptoms (14%, 12%, 13%), mean nevus base (5.6, 4.7, 5.2 mm), intrinsic nevus pigmentation (89%, 74%, 77%), related subretinal fluid (SRF) (11%, 15%, 9%), overlying orange pigment (6%, 10%, 6%), retinal pigment epithelial hyperplasia (0%, 9%, 7%), and retinal pigment epithelial atrophy (2%, 13%, 10%).
  • The following factors statistically increased with age category: multiple nevi per eye (2%, 8%, 10%) (P = 0.0001), mean nevus thickness (1.2, 1.5, 1.6 mm) (P<0.0001), and overlying drusen (11%, 40%, 58%) (P<0.0001).
  • Using multivariate analysis of the entire group, factors predictive of any symptom included nonpigmented nevus (P<0.001), location < or = 3 mm to foveola (P = 0.001), subfoveolar fluid (P = 0.002), any SRF (P = 0.02), and subfoveolar nevus (P = 0.027).
  • CONCLUSIONS: Choroidal nevi show similar clinical features regardless of age of presentation, with the exception of increasing number of nevi per eye, slightly increasing thickness, and increasing drusen in adults versus younger patients.
  • Symptomatic nevi are more likely to be nonpigmented, beneath the foveola, and with subfoveolar fluid.
  • [MeSH-major] Choroid Neoplasms / pathology. Nevus, Pigmented / pathology

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  • (PMID = 18067966.001).
  • [ISSN] 1549-4713
  • [Journal-full-title] Ophthalmology
  • [ISO-abbreviation] Ophthalmology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Shields CL, Mashayekhi A, Materin MA, Luo CK, Marr BP, Demirci H, Shields JA: Optical coherence tomography of choroidal nevus in 120 patients. Retina; 2005 Apr-May;25(3):243-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optical coherence tomography of choroidal nevus in 120 patients.
  • OBJECTIVE: To describe the optical coherence tomography (OCT) findings of choroidal nevi.
  • METHODS: Retrospective, single-center case series of 120 eyes of 120 consecutive patients with choroidal nevi who were evaluated by OCT.
  • Diagnostic imaging was performed with a Zeiss StratusOCT Model 3000 (Carl Zeiss Ophthalmic Systems, Dublin, CA) using scan acquisition protocols of 6 radial lines and retinal thickness analysis overlying the nevus.
  • The choroidal nevus was a mean of 5.2 mm in basal dimension and 1.7 mm in thickness and was located a mean of 2.7 mm from the optic disk and 2.5 mm from the foveola.
  • In comparison, related retinal findings at the site of the nevus by OCT included overlying retina edema (15%), subretinal fluid (26%), retinal thinning (22%), drusen (41%), and RPE detachment (12%).
  • Specific OCT findings of the choroidal nevus were limited to its anterior surface with minimal penetration into the mass.
  • These findings included increased thickness of the RPE/choriocapillaris layer (68%) and optical qualities within the anterior portion of the nevus of hyporeflectivity (62%), isoreflectivity (29%), and hyperreflectivity (9%).
  • Hyporeflectivity was observed in 68% of pigmented nevi and 18% of nonpigmented nevi.
  • CONCLUSIONS: OCT is a useful diagnostic modality for imaging the retina overlying a choroidal nevus.
  • [MeSH-major] Choroid Neoplasms / pathology. Diagnostic Techniques, Ophthalmological. Nevus, Pigmented / pathology. Tomography, Optical Coherence / methods

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  • (PMID = 15805899.001).
  • [ISSN] 0275-004X
  • [Journal-full-title] Retina (Philadelphia, Pa.)
  • [ISO-abbreviation] Retina (Philadelphia, Pa.)
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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15. Oiso N, Kawara S, Kawada A: Acquired melanocytic naevus in naevus depigmentosus. Clin Exp Dermatol; 2009 Oct;34(7):e311-2
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  • [Title] Acquired melanocytic naevus in naevus depigmentosus.
  • [MeSH-major] Hypopigmentation / complications. Nevus, Pigmented / etiology. Skin Neoplasms / etiology

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  • (PMID = 19456784.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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16. In SI, Kang HY: Partial unilateral lentiginosis colocalized with naevus depigmentosus. Clin Exp Dermatol; 2008 May;33(3):337-9
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  • [Title] Partial unilateral lentiginosis colocalized with naevus depigmentosus.
  • [MeSH-major] Lentigo / pathology. Nevus, Pigmented / pathology. Skin Neoplasms / pathology

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  • (PMID = 18419609.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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17. Kim DY, Park YK, Hann SK: Recurrence of nevus depigmentosus after an autologous epidermal graft. J Am Acad Dermatol; 2008 Mar;58(3):527-9
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  • [Title] Recurrence of nevus depigmentosus after an autologous epidermal graft.
  • [MeSH-major] Epidermis / transplantation. Hypopigmentation / surgery. Neoplasm Recurrence, Local. Nevus / surgery. Skin Neoplasms / surgery


18. Kim DY, Lee KY, Park YK: Use of the 308-nm excimer laser for nevus depigmentosus: a promising treatment for either nevus depigmentosus or vitiligo. J Dermatol; 2007 Mar;34(3):217-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of the 308-nm excimer laser for nevus depigmentosus: a promising treatment for either nevus depigmentosus or vitiligo.

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  • (PMID = 17291307.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Japan
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19. Gupta S, Goel A: Letter to the editor: nevus depigmentosus needs transplant of epidermal sheets. Dermatol Surg; 2005 Dec;31(12):1746-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Letter to the editor: nevus depigmentosus needs transplant of epidermal sheets.
  • [MeSH-major] Epidermis / transplantation. Hypopigmentation / surgery. Nevus / surgery. Skin Transplantation / methods

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  • (PMID = 16336906.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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20. Raskovic D, Bondanza S, Gobello T, Luci A, Zambruno G, Happle R, Guerra L: Autologous in vitro reconstituted epidermis in the treatment of a large nevus depigmentosus. J Am Acad Dermatol; 2006 May;54(5 Suppl):S238-40
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  • [Title] Autologous in vitro reconstituted epidermis in the treatment of a large nevus depigmentosus.
  • [MeSH-major] Epidermis / transplantation. Hypopigmentation / surgery. Melanocytes / transplantation. Nevus / surgery

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  • (PMID = 16631953.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Babilas P, Schreml S, Landthaler M, Vogt T: A 12-month-old boy with impaired pigmentation. Diagnosis: nevus depigmentosus. Pediatr Ann; 2009 Nov;38(11):617-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A 12-month-old boy with impaired pigmentation. Diagnosis: nevus depigmentosus.
  • [MeSH-major] Hypopigmentation / congenital. Nevus / congenital. Nevus / diagnosis

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  • (PMID = 19968206.001).
  • [ISSN] 0090-4481
  • [Journal-full-title] Pediatric annals
  • [ISO-abbreviation] Pediatr Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Sharma P, Pai HS, Kamath MM: Nevus depigmentosus affecting the iris and skin: a case report. J Eur Acad Dermatol Venereol; 2008 May;22(5):634-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nevus depigmentosus affecting the iris and skin: a case report.

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  • (PMID = 18410630.001).
  • [ISSN] 1468-3083
  • [Journal-full-title] Journal of the European Academy of Dermatology and Venereology : JEADV
  • [ISO-abbreviation] J Eur Acad Dermatol Venereol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Netherlands
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