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11. Scheinfeld N: A glistening brown nodule. Pigmented clear cell acanthoma. Arch Dermatol; 2007 Feb;143(2):255-60
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  • [Title] A glistening brown nodule. Pigmented clear cell acanthoma.
  • [MeSH-major] Acanthoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17310007.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Zedek DC, Murphy BA, Shea CR, Hitchcock MG, Reutter JC, White WL: Cutaneous clear-cell granular cell tumors: the histologic description of an unusual variant. J Cutan Pathol; 2007 May;34(5):397-404
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  • [Title] Cutaneous clear-cell granular cell tumors: the histologic description of an unusual variant.
  • BACKGROUND: Granular cell tumors (GCTs) are neoplasms showing nerve sheath differentiation that can arise in the skin but, to our knowledge, have not been associated with significant clear-cell morphology.
  • METHODS: Two patients developed four separate GCTs with distinctive, diffuse clear-cell change, which completely camouflaged the primary differentiation.
  • The morphology, histochemistry and immunohistochemistry of the lesions are described and are compared with the presence and extent of clear-cell change in 14 other cases of GCTs.
  • RESULTS: The index cases were relatively broad proliferations with uniform diffuse clear-cell change and only minimal overlying epidermal hyperplasia.
  • These clear-cell granular tumors were positive for S-100 protein, p75, CD68, NKI/C3 and neuron-specific enolase and were negative for epithelial mucin, periodic acid-Schiff, carcinoembryonic antigen, HMB-45, Melan-A, smooth muscle actin, Leu7, synaptophysin, CD34, factor XIIIa, epithelial membrane antigen and cytokeratin.
  • Three of the fourteen comparison cases were found to have no clear-cell change, eight showed focal clear-cell change and three showed moderate clear-cell change.
  • CONCLUSIONS: The distinctive morphology and the immunohistochemical results are discussed in the context of the differential diagnosis of clear-cell cutaneous tumors.
  • [MeSH-major] Granular Cell Tumor / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Acanthoma / pathology. Aged. Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged

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  • (PMID = 17448195.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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15. Akin FY, Ertam I, Ceylan C, Kazandi A, Ozdemir F: Clear cell acanthoma: new observations on dermatoscopy. Indian J Dermatol Venereol Leprol; 2008 May-Jun;74(3):285-7
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  • [Title] Clear cell acanthoma: new observations on dermatoscopy.
  • [MeSH-major] Acanthoma / pathology. Dermoscopy. Skin / pathology. Skin Neoplasms / pathology

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  • (PMID = 18583817.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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16. Arida M, English JC 3rd, Mully TW: Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report. Dermatol Online J; 2006;12(4):11
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  • [Title] Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report.
  • Clear cell acanthoma is a benign epidermal lesion with a variable clinical appearance and distinct histopathology features.
  • Although, it is considered an entirely benign entity, few case reports describe unusual or atypical variants of clear cell acanthoma.
  • We observed a case of a large clear cell acanthoma that also has features of a keratoacanthoma.
  • [MeSH-major] Acanthoma / pathology. Keratoacanthoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17083866.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 9005-79-2 / Glycogen
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17. Kovacs D, Cota C, Cardinali G, Aspite N, Bolasco G, Amantea A, Torrisi MR, Picardo M: Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. Exp Dermatol; 2006 Oct;15(10):762-8
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  • [Title] Expression of keratinocyte growth factor and its receptor in clear cell acanthoma.
  • The aetiopathogenic mechanism underlying clear cell acanthoma (CCA) is not completely clear and it has been postulated that CCA and psoriasis may have a similar pathogenesis because of the common features shared by the two diseases.
  • [MeSH-major] Acanthoma / metabolism. Fibroblast Growth Factor 7 / metabolism. Receptor, Fibroblast Growth Factor, Type 2 / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Aged. Cell Proliferation. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Middle Aged. Receptor, Epidermal Growth Factor / genetics. Receptor, Epidermal Growth Factor / metabolism

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  • (PMID = 16984257.001).
  • [ISSN] 0906-6705
  • [Journal-full-title] Experimental dermatology
  • [ISO-abbreviation] Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 126469-10-1 / Fibroblast Growth Factor 7; EC 2.7.1.- / keratinocyte growth factor receptor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Fibroblast Growth Factor, Type 2
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18. Shuweiter M, Böer A: Spectrum of follicular and sebaceous differentiation induced by dermatofibroma. Am J Dermatopathol; 2009 Dec;31(8):778-85
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  • RESULTS: The epidermis above dermatofibromas was acanthotic, simulating seborrheic keratosis in 62.9% of the cases, and areas of clear and pale cells similar to those of clear cell acanthoma were seen in 18.6%.
  • In 4%, formation of a complete hair follicle was encountered.
  • Not uncommonly, sebaceous structures were arranged in a reticulate pattern similar to that seen in reticulated acanthoma with sebaceous differentiation (12%).
  • [MeSH-minor] Cell Differentiation. Humans

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  • (PMID = 19955877.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Morrison LK, Duffey M, Janik M, Shamma HN: Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. Int J Dermatol; 2010 Sep;49(9):1008-11
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  • [Title] Clear cell acanthoma: a rare clinical diagnosis prior to biopsy.
  • BACKGROUND: Clear cell acanthoma is a rare, benign epidermal tumor with a clinical hybrid appearance and a distinct histological one.
  • OBJECTIVE: To evaluate the frequency that clear cell acanthoma was listed in the clinical differential diagnosis of histologically confirmed specimens.
  • METHODS: A regional dermatopathology lab database was evaluated from January 1998 through March 2008 for histologically diagnosed cases of clear cell acanthoma.
  • RESULTS: During this time period of review, 411 histologically confirmed cases of clear cell acanthoma were identified.
  • CONCLUSION: Clear cell acanthoma was rarely listed amongst the differential diagnosis of biopsy proven specimens.
  • [MeSH-major] Acanthoma / diagnosis. Skin Neoplasms / diagnosis

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  • (PMID = 20931670.001).
  • [ISSN] 1365-4632
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Monari P, Farisoglio C, Gualdi G, Botali G, Ungari M, Calzavara-Pinton P: Multiple eruptive clear cell acanthoma. J Dermatol Case Rep; 2010 Nov 19;4(2):25-7
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  • [Title] Multiple eruptive clear cell acanthoma.
  • BACKGROUND: Clear cell acanthoma is a rare solitary benign epidermal tumor of unknown etiology.
  • Although solitary lesions are the rule, less than 30 cases of multiple Clear cell acanthoma have been described in the literature to date.
  • MAIN OBSERVATIONS: We report an unusual case of a healthy 74-year-old male with multiple clear cell acanthoma on the lower extremities treated successfully with cryotherapy.
  • CONCLUSIONS: Despite significant progress in treatment of clear cell acanthoma, cryotherapy, based on liquid nitrogen, remains an important alternative in treating multiple clear cell acanthomas.

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  • (PMID = 21886743.001).
  • [ISSN] 1898-7249
  • [Journal-full-title] Journal of dermatological case reports
  • [ISO-abbreviation] J Dermatol Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Other-IDs] NLM/ PMC3157811
  • [Keywords] NOTNLM ; clear cell acanthoma / cryotherapy / multiple / tumor
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21. Hsu HC, Yang CH, Kuo TT, Shih IH, Hong HS: Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice. Int J Dermatol; 2007 Jun;46(6):615-8
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  • [Title] Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice.
  • Clear cell acanthoma (CCA) has never been described as an oozing umbilical nodule on infants.
  • [MeSH-major] Acanthoma / pathology. Skin Neoplasms / pathology. Umbilicus / pathology

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  • (PMID = 17550563.001).
  • [ISSN] 0011-9059
  • [Journal-full-title] International journal of dermatology
  • [ISO-abbreviation] Int. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Tanaka T, Arai T, Ishikawa T, Ohnishi T, Watanabe S: Pedunculated clear cell acanthoma. Report of a case with dermoscopic observation. Eur J Dermatol; 2010 Jan-Feb;20(1):132-3
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  • [Title] Pedunculated clear cell acanthoma. Report of a case with dermoscopic observation.
  • [MeSH-major] Acanthoma / pathology. Dermoscopy. Skin Neoplasms / pathology

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  • (PMID = 19889591.001).
  • [ISSN] 1167-1122
  • [Journal-full-title] European journal of dermatology : EJD
  • [ISO-abbreviation] Eur J Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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23. Morillo V, Manrique P, Zabalza I, Artola JL: [Eruptive clear cell acanthoma]. Actas Dermosifiliogr; 2009 Apr;100(3):244-6
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  • [Title] [Eruptive clear cell acanthoma].
  • [Transliterated title] Acantoma de células claras eruptivo.
  • [MeSH-major] Acanthoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 19457317.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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24. Al-Arashi MY, Byers HR: Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization. J Cutan Pathol; 2007 Mar;34(3):226-33
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  • [Title] Cutaneous clear cell squamous cell carcinoma in situ : clinical, histological and immunohistochemical characterization.
  • BACKGROUND: Clear cell squamous cell carcinoma in situ (SCCIS) has not been defined in the literature with respect to its clinical, histological, and immunohistochemical features.
  • METHODS: Nearly 1500 consecutive cases of SCCIS were assessed for percent clear cell change.
  • The clinical features of all SCCIS with >or=10% clear cell change, including age, sex and site distribution, were compared with classical SCCIS using chi-square analysis.
  • PAS special staining and immunohistochemical analysis with 11 cell markers were performed to characterize the clear cell of origin.
  • RESULTS: Eighty SCCIS cases with a spectrum of clear cell change of >or=10% were identified.
  • Six cases with >or=80% clear cells were defined as clear cell SCCIS.
  • Antibodies labeling outer root sheath (ORS) cells also labeled clear cells in the cases and included K8.12 (labeling CK13 and CK16), cellular retinoic acid binding protein II, CAM 5.2 and CK15.
  • CONCLUSION: Clear cell change in SCCIS is part of a spectrum which displays ORS differentiation.
  • [MeSH-major] Acanthoma / pathology. Carcinoma in Situ / pathology. Precancerous Conditions / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Count. Female. Humans. Immunoenzyme Techniques. Male. Periodic Acid-Schiff Reaction

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  • [CommentIn] J Cutan Pathol. 2008 May;35(5):513-4 [18261115.001]
  • (PMID = 17302606.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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25. Park SY, Jung JY, Na JI, Byun HJ, Cho KH: A case of polypoid clear cell acanthoma on the nipple. Ann Dermatol; 2010 Aug;22(3):337-40
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  • [Title] A case of polypoid clear cell acanthoma on the nipple.
  • Clear cell acanthoma (CCA) is a rare benign epidermal tumor.
  • We observed an unusual case of polypoid CCA on the nipple of a 14-year-old girl.

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  • (PMID = 20711275.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2917692
  • [Keywords] NOTNLM ; Clear cell acanthoma / Nipple
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