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Items 1 to 32 of about 32
1. Driemel O, Müller-Richter UD, Hakim SG, Bauer R, Berndt A, Kleinheinz J, Reichert TE, Kosmehl H: Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. Head Face Med; 2008;4:17
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma.
  • BACKGROUND: acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features.
  • METHODS: Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features.
  • Loss of cell-cell-adhesion, monitored by loss of E-cadherin and beta-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Hemangiosarcoma / pathology. Mouth / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Acantholysis. Aged. Biopsy, Needle. Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged


2. Zidar N, Gale N, Zupevc A, Dovsak D: Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases. J Clin Pathol; 2006 Nov;59(11):1206-8
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  • [Title] Pseudovascular adenoid squamous-cell carcinoma of the oral cavity--a report of two cases.
  • Two cases of pseudovascular adenoid squamous-cell carcinoma (SCC) in the oral cavity are described, which were characterised by acantholysis of the tumour cells, with formation of anastomosing spaces and channels mimicking an angiosarcoma.
  • Both tumours contained foci of SCC suggesting the correct diagnosis: in one patient conventional SCC, and in the other, a spindle-cell carcinoma.
  • The pathogenesis of pseudovascular adenoid SCC is unknown.
  • Pseudovascular adenoid SCC is suggested to be pathogenetically related to the loss of E-cadherin expression, leading to the loss of tumour cell-cell adhesion.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Aged. Cadherins / metabolism. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Male. Middle Aged. Neoplasm Proteins / metabolism


3. Massuet A, Fernández S, Rimola J, Andreu FJ, Tortajada L, Sentís M: [Metaplastic carcinoma of the breast: magnetic resonance and radiophatologic correlation]. Radiologia; 2006 May-Jun;48(3):155-63
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  • [Title] [Metaplastic carcinoma of the breast: magnetic resonance and radiophatologic correlation].
  • [Transliterated title] Carcinoma metaplásico de mama: resonancia magnética y correlación radiopatológica.
  • OBJECTIVES: To review our radiological experience in metaplastic carcinoma together with the clinical and histopathologic findings.
  • METHODS AND MATERIALS: Eight cases of histologically confirmed metaplastic carcinoma of breast were reviewed.
  • Metaplastic carcinoma presented as a palpable nodule in five cases, as a nipple retraction in ones case, and was discovered as an incidental mammographic finding in two.
  • In the dynamic study, all showed contrast uptake, with signal-time intensity curves similar to those of infiltrating carcinoma of the breast.
  • Histopathologic study found one squamous-cell, one sarcomatous, three chondroid, one giant-cell, one spindle-cell, and one acantholytic carcinoma, all of which were of high histologic grade.
  • CONCLUSIONS: Metaplastic carcinoma should be included in the differential diagnosis of a nodule presenting with high density and variable margins on mammography, low heterogeneous echogenicity and ill defined margins on sonography, and hyperintense at T2 with malignant enhancement at MR.
  • Immunohistochemical assessment is mandatory for the final diagnosis.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / radiography. Carcinoma / pathology. Carcinoma / radiography. Magnetic Resonance Imaging

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  • (PMID = 17058637.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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4. Kuraoka K, Takehara K, Oshita S, Saito A, Taniyama K: Acantholytic squamous cell carcinoma of the uterine cervix. Pathol Int; 2010 Mar;60(3):245-6
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  • [Title] Acantholytic squamous cell carcinoma of the uterine cervix.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 20403053.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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5. Kerawala CJ: Acantholytic squamous cell carcinoma of the oral cavity: a more aggressive entity? Br J Oral Maxillofac Surg; 2009 Mar;47(2):123-5
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  • [Title] Acantholytic squamous cell carcinoma of the oral cavity: a more aggressive entity?
  • Acantholytic squamous cell carcinoma is a histologically distinct variant of squamous cell carcinoma that arises most commonly in areas of the skin exposed to the sun.
  • It is rare on mucosal surfaces of the upper aerodigestive tract, where there is some suggestion that it might behave more aggressively than conventional squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Acantholysis. Fatal Outcome. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging

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  • (PMID = 18565630.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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6. Du X, Yin X, Zhou N, Zhang G, Shi H, Cao S: Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report. J Cutan Pathol; 2010 Jun;37(6):683-6
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  • [Title] Extramammary Paget's disease mimicking acantholytic squamous cell carcinoma in situ: a case report.
  • BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon skin neoplasm characterized by Paget's cells with pale-staining cytoplasm in the epidermis, and cases with distinguished acantholysis but lacking characteristic Paget's cells were rarely reported in the literature.
  • METHODS: An 80-year-old male with lesion on scrotum was screened histologically and immunohistologically for the diagnosis of his tumor.
  • RESULTS: Histological examination showed acanthosis with cellular atypia and focal acantholysis, consistent with acantholytic squamous cell carcinoma in situ (SCCIS).
  • CONCLUSIONS: These findings strongly indicated the diagnosis of EMPD mimicking acantholytic SCCIS.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Genital Neoplasms, Male / pathology. Paget Disease, Extramammary / pathology. Scrotum / pathology
  • [MeSH-minor] Aged, 80 and over. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 19615013.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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7. Papadopoulou E, Tosios KI, Nikitakis N, Papadogeorgakis N, Sklavounou-Andrikopoulou A: Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Jun;109(6):e67-71
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  • [Title] Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature.
  • Adenoid squamous cell carcinoma differs from common squamous cell carcinoma in histologic features and its aggressive nature.
  • Microscopically, the tumor shows cystic degeneration of the neoplastic epithelium, producing a prominent alveolar pattern and pseudoglandular structures with acantholytic cells.
  • An incisional biopsy rendered the diagnosis of adenoid squamous cell carcinoma.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Gingival Neoplasms / pathology. Neoplasm Recurrence, Local / pathology

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  • [Copyright] Copyright 2010 Mosby, Inc. All rights reserved.
  • (PMID = 20451835.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 20
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8. Aulmann S, Schnabel PA, Helmchen B, Dienemann H, Drings P, Otto HF, Sinn HP: Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast. Virchows Arch; 2005 Mar;446(3):305-9
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  • [Title] Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast.
  • Primary acantholytic squamous cell carcinoma (ASCC) of the breast is a rare and aggressive variant of invasive breast cancer.
  • The results of our analyses suggest that genetic alterations observed in ASCC of the breast include imbalances commonly observed in both mammary adenocarcinoma and squamous cell carcinoma of other locations.
  • [MeSH-major] Bone Neoplasms / secondary. Breast Neoplasms / genetics. Breast Neoplasms / pathology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. DNA, Neoplasm / genetics


9. Prasad KK, Kaur S: Acantholytic squamous cell carcinoma of the oral cavity: an uncommon histological variant of squamous cell carcinoma. Minerva Stomatol; 2010 Jun;59(6):377-80
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  • [Title] Acantholytic squamous cell carcinoma of the oral cavity: an uncommon histological variant of squamous cell carcinoma.
  • Acantholytic squamous cell carcinoma is a rare and aggressive histological variant of squamous cell carcinoma, characterized by tubular and alveolar patterns as a consequence of the acantholysis.
  • We report a case of acantholytic squamous cell carcinoma in a 70-year-old woman, who was admitted to our institution for the progressively enlarging exophytic and ulcerated lesion.
  • We report this interesting lesion due to the rarity of acantholytic variant of squamous cell carcinoma and the literature is briefly reviewed.
  • [MeSH-major] Carcinoma, Squamous Cell / prevention & control. Mouth Neoplasms / pathology


10. Horn LC, Liebert UG, Edelmann J, Höckel M, Einenkel J: Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature. Int J Gynecol Pathol; 2008 Apr;27(2):288-91
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  • [Title] Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature.
  • Pseudoangiosarcomatous squamous cell carcinoma is an unusual but aggressive variant of acantholytic squamous cell carcinoma of the vulva that mimics angiosarcoma on histology.
  • We present a case of a 57-year-old woman with bilateral inguinal metastatic disease at the time of diagnosis, who died 4 months later because of distant metastatic disease to the lungs.
  • Because of the positive p53 immunostaining and the association to lichen sclerosus and simple type of high-grade vulvar intraepithelial neoplasia, alteration of p53 tumor suppressor gene might be involved in the pathogenesis of vulvar pseudoangiosarcomatous squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Vulvar Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Hemangiosarcoma / diagnosis. Hemangiosarcoma / metabolism. Hemangiosarcoma / pathology. Humans. Middle Aged. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 18317210.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53
  • [Number-of-references] 16
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11. González-Vela MC, Val-Bernal JF, Mayorga M, Zaldumbide L, Báscones M: Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma. APMIS; 2006 Jun;114(6):470-3
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  • [Title] Adenoid squamous cell carcinoma of the larynx: an uncommon histological variant of squamous cell carcinoma.
  • Adenoid squamous cell carcinoma (ASCC) or acantholytic squamous cell carcinoma is a well-recognized variant of squamous cell carcinoma.
  • Biopsy was performed and the histological diagnosis was squamous cell carcinoma.
  • Microscopically, the tumor showed a prominent alveolar pattern with cystic degeneration of the neoplastic epithelium and formation of pseudoglandular structures.
  • In the lumina there were acantholytic cells.
  • Transition areas from conventional squamous cell carcinoma to adenoid pattern were found.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Laryngeal Neoplasms / pathology

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  • (PMID = 16856971.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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12. Qi XP, Lin GB, Zhu YL, Wang JQ, Dai XW, Ma JM, Yan L: [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses]. Zhonghua Nan Ke Xue; 2009 Feb;15(2):134-9
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  • [Title] [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses].
  • OBJECTIVE: To further understand the clinicopathological, ultrastructural and molecular features of penile pseudoangiosarcomatous squamous cell carcinoma (PASCC), and improve its diagnosis and treatment.
  • CT scanning showed no enlarged lymph nodes in the abdomen and pelvis, and X-ray examination revealed no abnormality in the chest.
  • RESULTS: The diagnosis was established by biopsy.
  • Under the light microsope, the tumor was mainly composed of vessel-like lacunar reticularis spindle cells and a few local squamous cancer cells.
  • Careful examination revealed some focal areas with evident transition from squamous nests to the more acantholytic areas extending towards the pseudoangiosarcomatous spaces.
  • Pathogenetically, it appeared to be the variant of acantholytic squamous cell carcinoma.
  • Immunohistochemically, most tumor cells were strongly positive for keratin (AE1/AE3) and focally positive for EMA, with the typical squamous cells focally positive for 34betaE12 and vimentin.
  • CONCLUSION: PASCC is a specific and extremely rare subtype of penile SCC with dramatic similarity to angiosarcoma under the microscope, with poor prognosis.
  • Its diagnosis depends on histopathological, immunohistochemical and ultrastructural studies.
  • Such a presentation underscores the importance of timely consultation, early diagnosis and prompt treatment.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Papillomaviridae / isolation & purification. Penile Neoplasms / pathology. Penile Neoplasms / virology

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  • (PMID = 19323373.001).
  • [ISSN] 1009-3591
  • [Journal-full-title] Zhonghua nan ke xue = National journal of andrology
  • [ISO-abbreviation] Zhonghua Nan Ke Xue
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
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13. Conde-Taboada A, Flórez A, De la Torre C, Feal C, García-Doval I, Cruces M: Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers. Am J Dermatopathol; 2005 Apr;27(2):142-4
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  • [Title] Pseudoangiosarcomatous squamous cell carcinoma of skin arising adjacent to decubitus ulcers.
  • Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma.
  • We report a case of pseudoangiosarcomatous squamous cell carcinoma arising adjacent to decubitus ulcers.
  • To our knowledge, our patient is the first with pseudoangiosarcomatous squamous cell carcinoma of skin developing within decubitus ulcer.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Pressure Ulcer / complications. Skin Neoplasms / complications
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Hemangiosarcoma / pathology. Humans. Immunohistochemistry

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  • (PMID = 15798440.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Kusafuka K, Ebihara M, Ishiki H, Takizawa Y, Iida Y, Onitsuka T, Takakuwa R, Kasami M, Ito I, Kameya T: Primary adenoid squamous cell carcinoma of the oral cavity. Pathol Int; 2006 Feb;56(2):78-83
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  • [Title] Primary adenoid squamous cell carcinoma of the oral cavity.
  • Adenoid squamous cell carcinoma (ASCC) is an uncommon but well-recognized variant of squamous cell carcinoma that was first described by Lever in 1947.
  • The biopsy material was diagnosed as squamous cell carcinoma.
  • Histologically, most parts of the lesion were conventional squamous cell carcinoma in situ, but the invasive part consisted of ASCC with gland-like or reticular appearance.
  • The Ki-67 labeling index was 50.3% in the ASCC part and 34.5% in the carcinoma in situ part.
  • These findings and a review of the literature indicate that a gland-like feature of ASCC is associated with the loss of cell adhesion in the center of the cancer nests, and it can be confirmed simply by mucin staining to be neither an adenosquamous carcinoma nor ductal involvement of conventional squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Cadherins / analysis. Carcinoma, Adenosquamous / chemistry. Carcinoma, Adenosquamous / diagnosis. Carcinoma, Adenosquamous / pathology. Carcinoma, Mucoepidermoid / chemistry. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / pathology. Cell Adhesion. Cell Proliferation. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratins / analysis. Middle Aged. Mucins / analysis. Tumor Suppressor Protein p53 / analysis


15. Zhang JP, Li CY: [The effect of transforming growth factor-beta1 on EDA region of fibronectin in oral squamous cell carcinoma and adenoid cystic carcinoma cells]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 Jan;42(1):47-51
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  • [Title] [The effect of transforming growth factor-beta1 on EDA region of fibronectin in oral squamous cell carcinoma and adenoid cystic carcinoma cells].
  • OBJECTIVE: To investigate the effect of transforming growth factor-beta1 (TGF-beta1) on EDA region of fibronectin in oral squamous cell carcinoma and adenoid cystic carcinoma cells.
  • In the three oral carcinoma cells, the expression of EDA(+) mRNAs in the group with TGF-beta1 was higher than that in the group without TGF-beta1 (P < 0.05).
  • CONCLUSIONS: TGF-beta1 could influence EDA region splicings and upregulate the expression of EDA region in Tca83, SACC-83 and SACC-LM cells, and might play an important role in accelerating oral carcinoma cells adhesion and tumor invasion and metastasis.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Squamous Cell / pathology. Fibronectins / metabolism. Mouth Neoplasms / pathology. Transforming Growth Factor beta1 / pharmacology
  • [MeSH-minor] Cell Line, Tumor. Humans. RNA, Messenger / metabolism

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  • (PMID = 17331445.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Fibronectins; 0 / RNA, Messenger; 0 / Transforming Growth Factor beta1
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16. Omulecki A, Lesiak A, Narbutt J, Woźniacka A, Piekarski J, Biernat W: Plaque form of warty dyskeratoma - acantholytic dyskeratotic acanthoma. J Cutan Pathol; 2007 Jun;34(6):494-6
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  • [Title] Plaque form of warty dyskeratoma - acantholytic dyskeratotic acanthoma.
  • Clinically, squamous cell carcinoma was suspected, but the histological features resembled those of isolated Darier's disease or pemphigus vegetans.
  • The lesion was removed with the final diagnosis of acantholytic dyskeratotic acanthoma.
  • We discuss this case with special regard to the differential diagnosis of other isolated acantholytic acanthomas.
  • [MeSH-minor] Diagnosis, Differential. Epidermis / pathology. Humans. Keratinocytes / pathology. Male. Middle Aged. Treatment Outcome

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  • (PMID = 17518779.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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17. Giordano G, D'Adda T, Merisio C, Gnetti L: Vulvar acantholytic squamous carcinoma: a case report with immunohistochemical and molecular study. Int J Gynecol Pathol; 2005 Jul;24(3):303-6
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  • [Title] Vulvar acantholytic squamous carcinoma: a case report with immunohistochemical and molecular study.
  • Acantholytic carcinoma is a subtype of squamous carcinoma, characterized by tubular and alveolar formations as a consequence of the acantholysis.
  • We report a case of vulvar squamous acantholytic carcinoma (VSAC) in a 69-year-old woman, who was admitted to our institution for vulvar pruritus and the presence of a large, bilateral, exophytic, and ulcerated lesion, measuring 7 x 8 cm.
  • In conclusion, our case, which is the first case of VSAC with polymerase chain reaction analysis and immunohistochemical expression of p16 protein, suggested that this neoplasm could be related to human papillomavirus infection.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 15968209.001).
  • [ISSN] 0277-1691
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / KRT14 protein, human; 0 / Keratin-14; 0 / Vimentin; 68238-35-7 / Keratins
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18. Cunha IW, Guimaraes GC, Soares F, Velazquez E, Torres JJ, Chaux A, Ayala G, Cubilla AL: Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma: a clinicopathologic and outcome study of 7 patients. Am J Surg Pathol; 2009 Apr;33(4):551-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma: a clinicopathologic and outcome study of 7 patients.
  • Almost half of penile squamous cell carcinomas (SCCs) are of the usual type but there is a variegated spectrum of morphologically distinctive subtypes.
  • In a pathologic review of 375 uniformly diagnosed and treated patients with penile SCC, we found 7 tumors with predominant pseudoglandular or adenoid features.
  • The aim of the study was to delineate clinicopathologic features and outcome of an unusual variant of penile SCC.
  • Microscopically, tumors were SCC with acantholytic areas ranging from solid nests with early necrosis or empty pseudoluminal spaces lined by 1 layer of squamous cells or cylindrical cells strikingly simulating glands.
  • The differential diagnosis was with gland forming penile tumors (surface adenosquamous, mucoepidermoid, and urethral adenocarcinomas) and the angiosarcomatoid variant of sarcomatoid carcinomas.
  • The other 5 were either alive with no evidence of disease (12 and 21 y after diagnosis) or died from causes other than penile cancer (3, 4, and 7 y after diagnosis).
  • Comparing with usual SCCs, pseudoglandular SCCs were of higher grade (88% vs. 44%), invaded deeper into CC (71% vs. 52%), and showed a higher incidence of regional metastasis (42% vs. 25%) and higher mortality (29% vs. 19%).
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / pathology. Penile Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Treatment Outcome

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  • [CommentIn] Am J Surg Pathol. 2009 Sep;33(9):1421-2 [19609203.001]
  • (PMID = 19033863.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Satter EK: Pigmented squamous cell carcinoma. Am J Dermatopathol; 2007 Oct;29(5):486-9
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  • [Title] Pigmented squamous cell carcinoma.
  • Although dendritic, melanin-containing melanocytes can be seen in a variety of epithelial neoplasms, only 0.01% to 7% of all squamous cell carcinomas (SCC) are pigmented.
  • Herein we report a case of a 61-year-old Caucasian male who presented with a large blue-black nodule on his left cheek, clinically suspicious for a melanoma; however, histological evaluation revealed an acantholytic pigmented squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Pigmentation. Skin Neoplasms / pathology

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  • (PMID = 17890923.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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20. Chute DJ, Stelow EB: Cytology of head and neck squamous cell carcinoma variants. Diagn Cytopathol; 2010 Jan;38(1):65-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cytology of head and neck squamous cell carcinoma variants.
  • The most common diagnosis rendered with head and neck fine needle aspiration (FNA) biopsy is metastatic squamous cell carcinoma (SCC).
  • While most cases of metastatic SCC pose little diagnostic difficulty, the diagnosis of metastatic histologic variants of SCC, often coupled with less common etiologies, can be more problematic.
  • This manuscript reviews the clinicopathologic features of the histologic variants of upper aerodigestive tract SCC (verrucous, papillary, spindle cell, undifferentiated, acantholytic, and basaloid) and uncommon etiologies of head and neck SCC (human papillomavirus, Epstein-Barr Virus, and NUT midline carcinomas).
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19582815.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 122
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21. Stelow EB, Mills SE: Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol; 2005 Dec;124 Suppl:S96-109
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  • [Title] Squamous cell carcinoma variants of the upper aerodigestive tract.
  • Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract.
  • Certain variants, however, can histologically mimic benign and other malignant diseases.
  • In such cases, correct diagnosis is important for prognostic and therapeutic reasons.
  • This article discusses the clinicopathologic features of the upper aerodigestive tract variants of SCC, including verrucous carcinoma, papillary squamous cell carcinoma, basaloid squamous cell carcinoma, spindle cell carcinoma, adenosquamous carcinoma, adenoid squamous cell carcinoma, and undifferentiated carcinoma.
  • It also discusses the differential diagnoses that must be considered and the use of ancillary testing, especially immunohistochemical analysis, for determining the correct diagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Digestive System Neoplasms / pathology
  • [MeSH-minor] Carcinoma, Adenosquamous / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Papillary / pathology. Humans

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  • (PMID = 16468420.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 109
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22. Cassarino DS, Derienzo DP, Barr RJ: Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two. J Cutan Pathol; 2006 Apr;33(4):261-79
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two.
  • Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential.
  • However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC.
  • Therefore, we have proposed the following based upon the malignant potential of SCC variants, separating them into categories of low (< or = 2% metastatic rate), intermediate (3-10%), high (greater than 10%), and indeterminate behavior.
  • Low-risk SCCs include SCC arising in actinic keratosis, HPV-associated SCC, tricholemmal carcinoma, and spindle cell SCC (unassociated with radiation).
  • Intermediate-risk SCCs include adenoid (acantholytic) SCC, intraepidermal epithelioma with invasion, and lymphoepithelioma-like carcinoma of the skin.
  • High-risk subtypes include de novo SCC, SCC arising in association with predisposing factors (radiation, burn scars, and immunosuppression), invasive Bowen's disease, adenosquamous carcinoma, and malignant proliferating pilar tumors.
  • The indeterminate category includes signet ring cell SCC, follicular SCC, papillary SCC, SCC arising in adnexal cysts, squamoid eccrine ductal carcinoma, and clear-cell SCC.
  • Subclassification of SCC into these risk-based categories, along with enumeration of other factors including tumor size, differentiation, depth of invasion, and perineural invasion will provide prognostically relevant information and facilitate the most optimal treatment for patients.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Dermatology / methods. Diagnosis, Differential. Humans. Neoplastic Processes. Pathology, Surgical / methods. Risk Factors


23. Cassarino DS, Derienzo DP, Barr RJ: Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. J Cutan Pathol; 2006 Mar;33(3):191-206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one.
  • Cutaneous squamous cell carcinoma (SCC) includes many subtypes with widely varying clinical behaviors, ranging from indolent to aggressive tumors with significant metastatic potential.
  • However, the tendency for pathologists and clinicians alike is to refer to all squamoid neoplasms as generic SCC.
  • Therefore, we have proposed the following based upon the malignant potential of SCC variants, separating them into categories of low (< or = 2% metastatic rate), intermediate (3-10%), high (greater than 10%), and indeterminate behavior.
  • Low-risk SCCs include SCC arising in actinic keratosis, HPV-associated SCC, tricholemmal carcinoma, and spindle cell SCC (unassociated with radiation).
  • Intermediate-risk SCCs include adenoid (acantholytic) SCC, intraepidermal epithelioma with invasion, and lymphoepithelioma-like carcinoma of the skin.
  • High-risk subtypes include de novo SCC, SCC arising in association with predisposing factors (radiation, burn scars, and immunosuppression), invasive Bowen's disease, adenosquamous carcinoma, and malignant proliferating pilar tumors.
  • The indeterminate category includes signet ring cell SCC, follicular SCC, papillary SCC, SCC arising in adnexal cysts, squamoid eccrine ductal carcinoma, and clear-cell SCC.
  • Subclassification of SCC into these risk-based categories, along with enumeration of other factors including tumor size, differentiation, depth of invasion, and perineural invasion will provide prognostically relevant information and facilitate the most optimal treatment for patients.
  • [MeSH-major] Carcinoma, Squamous Cell / classification. Carcinoma, Squamous Cell / pathology. Skin Neoplasms / classification. Skin Neoplasms / pathology
  • [MeSH-minor] Dermatology / methods. Diagnosis, Differential. Humans. Neoplastic Processes. Pathology, Surgical / methods. Risk Factors

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  • (PMID = 16466506.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 234
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24. Chaux A, Velazquez EF, Algaba F, Ayala G, Cubilla AL: Developments in the pathology of penile squamous cell carcinomas. Urology; 2010 Aug;76(2 Suppl 1):S7-S14
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Developments in the pathology of penile squamous cell carcinomas.
  • Most penile cancers are squamous cell carcinoma (SCC) originating in the epithelium covering glans, coronal sulcus, and foreskin.
  • The most common subtype is the usual SCC, representing one half to two thirds of penile carcinomas.
  • Other SCC variants, such as carcinoma cuniculatum and pseudohyperplastic, adenosquamous and acantholytic carcinomas, are rare.
  • The most relevant clinicopathologic and outcome features are outlined for each of these SCC subtypes, and an algorithm that might aid the pathologist in the histologic classification is presented.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Consensus. Penile Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20691888.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 52
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25. Moreno-Maldonado R, Ramírez A, Navarro M, Fernández-Aceñero MJ, Villanueva C, Page A, Jorcano JL, Bravo A, Llanos Casanova M: IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. Cell Cycle; 2008 Jul 1;7(13):2021-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas.
  • Squamous cell carcinomas (SCCs) of the skin display different clinical features according to their epithelial differentiation grade and histological variant.
  • Increased expression of IKKalpha in mouse tumorigenic epidermal cells leads to changes in the differentiation pattern of the resulting SCCs, originating a distinct histological variant that resembles the human acantholytic SCC (ASCC) variant.
  • The tight correlation between the properties of both murine and human ASCC variants strongly suggests that IKKalpha is responsible for the development of this human SCC variant.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. I-kappa B Kinase / metabolism. Keratinocytes / cytology. Keratinocytes / metabolism. Protein-Serine-Threonine Kinases / metabolism
  • [MeSH-minor] Animals. Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism. Cadherins / metabolism. Cell Differentiation. Cell Line. Epidermis / metabolism. Humans. Mice. Skin Neoplasms / metabolism. Skin Neoplasms / pathology. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 18604171.001).
  • [ISSN] 1551-4005
  • [Journal-full-title] Cell cycle (Georgetown, Tex.)
  • [ISO-abbreviation] Cell Cycle
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; 0 / Cadherins; 0 / Vascular Endothelial Growth Factor A; EC 2.7.1.- / Chuk protein, mouse; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 2.7.11.10 / I-kappa B Kinase; EC 2.7.11.25 / NF-kappa B kinase
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26. Ly V, Gupta S, Desoto F, Cutaia M: Tracheal squamous cell carcinoma treated endoscopically. J Bronchology Interv Pulmonol; 2010 Oct;17(4):353-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tracheal squamous cell carcinoma treated endoscopically.
  • Malignant primary tracheal tumors are extremely rare.
  • The most common malignant primary tracheal tumors are squamous cell carcinoma and adenoid cystic carcinomas.
  • In this brief report, we describe a patient who presented with a primary papillary squamous cell carcinoma in-situ at multiple areas in the trachea with a significant airway obstruction.

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  • (PMID = 23168962.001).
  • [ISSN] 1944-6586
  • [Journal-full-title] Journal of bronchology & interventional pulmonology
  • [ISO-abbreviation] J Bronchology Interv Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Takahashi O, Okushiba S, Kondo S, Morikawa T, Hirano S, Miyamoto M, Shichinohe T, Hara T, Kawarada Y, Saito K, Takeuchi M: Esophageal pemphigus vulgaris with carcinoma: postoperative steroid therapy based on pemphigus-related antibodies. Dis Esophagus; 2005;18(6):413-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Esophageal pemphigus vulgaris with carcinoma: postoperative steroid therapy based on pemphigus-related antibodies.
  • A biopsy specimen was diagnosed pathologically as squamous cell carcinoma.
  • Histopathologic examination of the resected specimen additionally showed blisters and acantholytic cells throughout the esophageal mucosa, so esophageal pemphigus was diagnosed in addition to carcinoma.
  • We initiated steroid therapy, making adjustments according to changes in titers of anti-intercellular bridge antibody and antibodies to the cell adhesion molecules (desmoglein 1 and 3).

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  • (PMID = 16336615.001).
  • [ISSN] 1120-8694
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / Desmogleins; 9PHQ9Y1OLM / Prednisolone
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28. Ojiri H: Perineural spread in head and neck malignancies. Radiat Med; 2006 Jan;24(1):1-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although representative histologies are squamous cell carcinoma and adenoid cystic carcinoma, other malignancies such as malignant lymphoma and sarcoma also can show such a specific pattern of extent.
  • PNS can be insidious, often delaying diagnosis.
  • Knowledge of anatomy of the nerves is crucial in the imaging diagnosis of PNS, to detect early curable disease.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Cranial Nerve Neoplasms / secondary. Head and Neck Neoplasms / pathology

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  • (PMID = 16715655.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Contrast Media
  • [Number-of-references] 12
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29. Aksu K, Aktaş Z, Aksu F, Orsel O, Demirağ F, Sipit T, Firat Güven S: Spindle cell sarcomatoid carcinoma: first case reported in the trachea. Tuberk Toraks; 2009;57(3):337-41

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  • [Title] Spindle cell sarcomatoid carcinoma: first case reported in the trachea.
  • Microscopically, the tumor was composed of fascicular pattern of spindle cells with atypical mitotic figures and nuclear pleomorphism, positively reactive to epithelial membrane antigen supporting a diagnosis of tumour with epithelial differentiation.
  • These findings supported the diagnosis of a spindle cell sarcomatoid carcinoma of trachea.
  • Spindle cell carcinoma cases are reported in many sites, such as head and neck region, larynx, digestive tract, breast, kidney, genital tract, skin and lung, but to our knowledge, not in trachea.
  • Primary malignant tracheal tumours consist mainly of squamous cell carcinoma and adenoid cystic carcinoma and generally have an aggressive course with poor prognosis.
  • We report the first presentation of a spindle cell sarcomatoid carcinoma of trachea together with the clinical course of the patient.
  • [MeSH-major] Carcinoma / pathology. Tracheal Neoplasms / pathology

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  • (PMID = 19787474.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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30. Liu FY, Liu XY, Wang Z, Liu Y: [The long-term outcome and prognostic analysis of surgically treated patients with trachea tumors]. Zhonghua Wai Ke Za Zhi; 2009 Jul 15;47(14):1055-7

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  • RESULTS: The histological examination of resected lesions revealed squamous cell carcinoma in 19 cases, adenoid cystic carcinoma in 8 cases, adenocarcinoma in 2 cases, carcinoid in 2 cases, leiomyosarcoma in 1 case and adenoma in 1 case.
  • CONCLUSIONS: Squamous cell carcinoma adenoid cystic carcinoma are the most common in trachea tumors.

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  • (PMID = 19781267.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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31. Resnik KS, DiLeonardo M: Incidental granular parakeratotic cornification in carcinomas. Am J Dermatopathol; 2007 Jun;29(3):264-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Similar to acantholytic dyskeratosis and epidermolytic hyperkeratosis, it may histopathologically represent a diagnostic finding in a specific dermatosis, one of the diagnostic features in a solitary keratosis or an incidental finding.
  • [MeSH-major] Carcinoma / pathology. Keratinocytes / pathology. Keratoacanthoma / pathology. Neoplasms, Radiation-Induced / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Carcinoma in Situ / pathology. Carcinoma, Basal Cell / pathology. Carcinoma, Squamous Cell / pathology. Cytoplasmic Granules / pathology. Female. Humans. Male. Middle Aged. Ultraviolet Rays / adverse effects

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  • (PMID = 17519624.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Colecchia M, Insabato L: Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma. Am J Surg Pathol; 2009 Sep;33(9):1421-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pseudoglandular (adenoid, acantholytic) penile squamous cell carcinoma.
  • [MeSH-major] Acantholysis / pathology. Carcinoma, Squamous Cell / secondary. Penile Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Fatal Outcome. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Middle Aged. Treatment Outcome

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  • [CommentOn] Am J Surg Pathol. 2009 Apr;33(4):551-5 [19033863.001]
  • (PMID = 19609203.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] United States
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