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1. Moreno Gijón M, Granero Castro P, Fernández García MS, Vázquez Velasco L, González González JJ: [Granular cell tumor of the appendix]. Rev Esp Enferm Dig; 2009 Jul;101(7):512-3
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  • [Title] [Granular cell tumor of the appendix].
  • [Transliterated title] Tumor de células granulares apendicular.
  • [MeSH-major] Appendiceal Neoplasms. Granular Cell Tumor

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  • (PMID = 19642848.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter; Review
  • [Publication-country] Spain
  • [Number-of-references] 7
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2. Takei H, Goodman JC, Tanaka S, Bhattacharjee MB, Bahrami A, Powell SZ: Pituicytoma incidentally found at autopsy. Pathol Int; 2005 Nov;55(11):745-9
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  • Pituicytoma is a rare benign neoplasm, occurring in the sellar and suprasellar regions.
  • The tumor was composed primarily of bipolar, occasionally unipolar, cells with syncytial fibrillary cytoplasm, arranged in short curvilinear fascicles and/or storiform patterns.
  • Unusual histological features were seen, which included a few groups of large pleomorphic tumor cells with abundant, glassy, eosinophilic cytoplasm, occasionally associated with multinucleated giant tumor cells, and scattered Herring bodies within the tumor.
  • Immunohistochemically, the tumor showed diffuse strong expression of glial fibrillary acidic protein, S-100 protein, and vimentin.
  • Epithelial membrane antigen immunoreactivity was focally observed, mainly in the large tumor cells.
  • Distinction from other intrasellar tumors (granular cell tumor and pilocytic astrocytoma) is important.
  • Because the immunohistochemical profiles of these tumors are similar, histological findings are crucial for distinction.

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  • (PMID = 16271088.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 0 / S100 Proteins; 0 / Vimentin
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3. Brower A, Herold LV, Kirby BM: Canine cardiac mesothelioma with granular cell morphology. Vet Pathol; 2006 May;43(3):384-7
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  • [Title] Canine cardiac mesothelioma with granular cell morphology.
  • Cardiac mesothelioma with granular cell features was diagnosed in a 10-year-old Golden Retriever presenting with pericardial and abdominal effusions.
  • The diagnosis was based on gross, morphologic, and immunohistochemical features.
  • The immunohistochemical profile of the neoplasm was pancytokeratin positive, vimentin positive, and S-100 negative; most gross and morphologic features were consistent with both mesothelioma and granular cell tumor.
  • To the authors' knowledge, the prognosis for either primary cardiac mesothelioma or granular cell tumor in the dog is unknown.
  • We describe a granular morphologic variant of cardiac mesothelioma in a dog.

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  • (PMID = 16672591.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Weinstein BJ, Arora T, Thompson LD: Intradural, extramedullary spinal cord granular cell tumor: a case report and clinicopathologic review of the literature. Neuropathology; 2010 Dec;30(6):621-6
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  • [Title] Intradural, extramedullary spinal cord granular cell tumor: a case report and clinicopathologic review of the literature.
  • Granular cell tumor (GCT) of the spine is uncommon, with intradural extramedullary location being exceptionally rare.
  • The non-specific clinical presentation and variable histologic patterns can make recognition of this tumor challenging.
  • The tumors were found at T10 or L1-L2 space.
  • Radiographically, all tumors enhanced homogenously on T1 post-gadolinium imaging with a mean tumor size of approximately 1.6 cm.
  • Histologically, the tumors were composed of large, polygonal granular cells.
  • The abundant cytoplasm was fine or coarsely granular, surrounding small, pale-staining nuclei, which were eccentrically located in the cell.
  • The tumor cells were periodic acid Schiff positive, diastase resistant, and were positive with S-100 protein, CD68, inhibin, and neuron-specific enolase immunohistochemistry.
  • The clinical and histologic differential diagnosis includes schwannoma, neurofibroma, meningioma, astrocytoma, melanocytoma, and metastatic tumors.
  • One patient had symptomatic and radiographic local recurrence that was subsequently treated with radiation, resulting in stabilization of disease and symptoms.
  • Intradural GCTs of the spine are rare and radiographically indistinguishable from tumors that more commonly arise in this location.
  • Histologic recognition of this rare tumor is important because the subsequent clinical course of the disease differs from other similar lesions.
  • [MeSH-major] Granular Cell Tumor / pathology. Spinal Cord Neoplasms / pathology

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  • [Copyright] © 2010 Japanese Society of Neuropathology.
  • (PMID = 20113407.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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5. Sargenti-Neto S, Brazão-Silva MT, do Nascimento Souza KC, de Faria PR, Durighetto-Júnior AF, Loyola AM, Cardoso SV: Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions. Br J Oral Maxillofac Surg; 2009 Jan;47(1):62-4
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  • [Title] Multicentric granular cell tumor: report of a patient with oral and cutaneous lesions.
  • Granular cell tumor (GCT) is an uncommon benign neoplasm of soft tissue that characteristically affects the oral cavity, with increased frequency in the tongue.
  • In view of the present findings, aspects related to clinical presentation, multiplicity, malignant potential, and treatment of GCT are discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Lip Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Skin Neoplasms / pathology. Tongue Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Genital Neoplasms, Female / surgery. Humans. Neoplasm Recurrence, Local. Perineum / pathology. Perineum / surgery

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  • (PMID = 18976838.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Scotland
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6. Qu J, Ma J, Luo L, Ai L, Li S, Dai J: Subdural granular cell tumor in thoracic vertebral canal. Neurol India; 2009 Sep-Oct;57(5):679-81
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  • [Title] Subdural granular cell tumor in thoracic vertebral canal.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Spinal Canal / pathology. Spinal Neoplasms / diagnosis

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  • (PMID = 19934580.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] India
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7. Poyraz CE, Kiratli H, Söylemezoğlu F: Granular cell tumor of the inferior rectus muscle. Korean J Ophthalmol; 2009 Mar;23(1):43-5
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  • [Title] Granular cell tumor of the inferior rectus muscle.
  • Excisional biopsy of the mass revealed granular cell tumor composed of S-100 positive cells with acidophilic granular cytoplasm and a peripheral lymphocytic infiltration.
  • Granular cell tumor, which is very rare in the orbit, should be considered in the differential diagnosis of tumors adjacent to or within the extraocular muscles, particularly in the inferior orbit.
  • [MeSH-major] Eye Neoplasms / pathology. Granular Cell Tumor / pathology. Muscle Neoplasms / pathology. Oculomotor Muscles / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged

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  • [Cites] Plast Reconstr Surg. 1969 Mar;43(3):315-7 [4305121.001]
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  • (PMID = 19337479.001).
  • [ISSN] 2092-9382
  • [Journal-full-title] Korean journal of ophthalmology : KJO
  • [ISO-abbreviation] Korean J Ophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2655740
  • [Keywords] NOTNLM ; Extraocular muscle / Granular cell tumor / Inferior rectus / Magnetic resonance imaging / Orbit
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8. Kanotra S, Kanotra SP, Paul J: Congenital epulis. J Laryngol Otol; 2006 Feb;120(2):148-50
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  • Congenital epulis or gingival granular cell tumour is a rare lesion occurring in the newborn, affecting females eight times more than males and arising more commonly from the maxillary than the mandibular alveolar ridge.

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  • (PMID = 16359158.001).
  • [ISSN] 0022-2151
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Bean SM, Eloubeidi MA, Eltoum IA, Cerfolio RJ, Jhala DN: Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA: a case report and review of the literature. Cytojournal; 2005 Jun 8;2(1):8
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  • [Title] Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA: a case report and review of the literature.
  • We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer.
  • Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei.
  • An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules.
  • Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes.
  • This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.

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  • [Cites] Acta Cytol. 1999 Jul-Aug;43(4):552-7 [10432874.001]
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  • (PMID = 15943858.001).
  • [ISSN] 1742-6413
  • [Journal-full-title] CytoJournal
  • [ISO-abbreviation] Cytojournal
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1184093
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10. Ignaczuk J, Dziuba-Zyła D, Zawiślak J, Polberg K, Wróblewska-Boniek B, Obszańska B, Stepulak A: [Granular cell tumour of the larynx--report of two cases]. Pol Merkur Lekarski; 2005 Sep;19(111):442-3
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  • [Title] [Granular cell tumour of the larynx--report of two cases].
  • [Transliterated title] Guz abrikosowa krtani--analiza dwóch przypadków.
  • Granular cell tumour (Abrikosov tumour) of the larynx is an uncommon laryngeal tumour.
  • We report two cases of this rare type of tumor, which were diagnosed and treated at the Department of Otolaryngology of District Hospital in Zamość in the period 1999-2005.
  • The tumours were detected in two adult men.
  • In the first case (29 years old patient) the tumour was located next to the right arytenoid.
  • The tumour was removed by microlaryngoscopy.
  • In the second case (55 years old patient) the tumour involved half right vocal fold from the posterior commissure.
  • Both tumours have not recurred after a 5 years follow-up and are still under observation.
  • [MeSH-major] Granular Cell Tumor. Laryngeal Neoplasms

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  • (PMID = 16358903.001).
  • [ISSN] 1426-9686
  • [Journal-full-title] Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
  • [ISO-abbreviation] Pol. Merkur. Lekarski
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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11. Aquilina K, Kamel M, Kalimuthu SG, Marks JC, Keohane C: Granular cell tumour of the neurohypophysis: a rare sellar tumour with specific radiological and operative features. Br J Neurosurg; 2006 Feb;20(1):51-4
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  • [Title] Granular cell tumour of the neurohypophysis: a rare sellar tumour with specific radiological and operative features.
  • Symptomatic granular cell tumours of the neurohypophysis are rare sellar lesions.
  • Preoperative prediction of the diagnosis on the basis of radiological appearance is useful as these tumours carry specific surgical difficulties.
  • This is possible when the tumour arises from the pituitary stalk, rostral to a normal pituitary gland.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Pituitary Gland, Posterior. Pituitary Neoplasms / diagnosis

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  • (PMID = 16698612.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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12. Dogramaci Y, Kalaci A, Sevinc TT, Hakverdi S, Canda S, Yanat AN: Granular cell tumor of the posterior tibial nerve as a rare cause of heel pain: a case report. J Am Podiatr Med Assoc; 2009 May-Jun;99(3):254-7
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  • [Title] Granular cell tumor of the posterior tibial nerve as a rare cause of heel pain: a case report.
  • Granular cell tumor of peripheral nerves is extremely rare.
  • We present the case of a patient with a well-capsulated intraneural granular cell tumor involving the posterior tibial nerve, who presented with chronic heel pain mimicking plantar fasciitis.
  • Histopathologic examination showed a granular cell tumor, which is extremely rare in the peripheral nerves.
  • Posterior tibial nerve lesions at the leg should be kept in mind in the differential diagnosis of patients with persistent heel and foot pain.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Heel. Pain / etiology. Peripheral Nervous System Neoplasms / diagnosis. Tibial Nerve
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 19448179.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. You XL, Yin RT, Li KM, Wang DQ, Li L, Yang KX: [Clinical and pathological analysis on ovarian granulosa cell tumors]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2010 May;41(3):467-70
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  • [Title] [Clinical and pathological analysis on ovarian granulosa cell tumors].
  • OBJECTIVE: To identify different clinical and pathological features for adult and juvenile granulosa cell tumors.
  • METHODS: The clinical records of 42 patients with granulosa cell tumors of ovary, including pathological features, treatments and follow up results between April 2001 and September 2009 were reviewed. RESULTS:.
  • Inhibin, calretinin, and vimentin were demonstrated to be useful for the diagnosis of granulose cell tumors.
  • CONCLUSION: With low incidence rate, ovarian granulosa cell tumor is a low-grade malignant and functional tumor.
  • Most Adult-type granulosa cell tumors occur in middle aged and elderly people, while most juvenile granulosa cell tumors occur in adolescents and children.
  • Acute abdomen symptom may occur but ascites are less likely to occur in patients with granular cell tumors than those with epithelial ovarian cancers.
  • Ovarian granulosa cell tumors are usually detected early, but easily relapse.
  • [MeSH-major] Granulosa Cell Tumor / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 20629323.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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14. Chaudhry A, Griffiths EA, Shah N, Ravi S: Surgical excision of an abdominal wall granular cell tumour with Permacol(R) mesh reconstruction: a case report. Int Semin Surg Oncol; 2008;5:4
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  • [Title] Surgical excision of an abdominal wall granular cell tumour with Permacol(R) mesh reconstruction: a case report.
  • INTRODUCTION: Granular cell tumours of the abdominal wall are extremely rare: less than 10 have been reported in the worldwide medical literature.
  • We report this interesting case, review the relevant literature on this tumour and discuss surgical abdominal wall reconstruction options.
  • Histopathological examination of the surgical specimen showed it to be a granular cell tumour.
  • CONCLUSION: Although rare, granular cell tumours can present as an abdominal wall mass.
  • The closure of large defects, after surgical resection of abdominal wall tumours, is a surgical challenge.

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  • (PMID = 18298854.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2267469
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15. Elmberger PG, Sköld CM, Collins BT: Fine needle aspiration biopsy of intrabronchial granular cell tumor. Acta Cytol; 2005 Mar-Apr;49(2):223-4
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  • [Title] Fine needle aspiration biopsy of intrabronchial granular cell tumor.
  • [MeSH-major] Bronchi / pathology. Bronchial Neoplasms / pathology. Granular Cell Tumor / pathology
  • [MeSH-minor] Biopsy, Fine-Needle. Cell Nucleus / pathology. Cytoplasm / pathology. Cytoplasmic Granules / pathology. Diagnosis, Differential. Humans. Middle Aged. Neoplasm Metastasis / pathology. Neoplasm Metastasis / physiopathology

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  • (PMID = 15839633.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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16. Toprak M, Oz F, Oktem F, Acioğlu E, Yilmaz S: Granular cell tumour of the larynx. J Otolaryngol; 2005 Oct;34(5):363-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Granular cell tumour of the larynx.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Laryngeal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Immunohistochemistry. Laryngoscopy. Male. Middle Aged. Sex Factors

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  • (PMID = 16181602.001).
  • [ISSN] 0381-6605
  • [Journal-full-title] The Journal of otolaryngology
  • [ISO-abbreviation] J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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17. Adeyemi BF, Oluwasola AO, Adisa AO: Congenital epulis. Indian J Dent Res; 2010 Apr-Jun;21(2):292-4
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  • Congenital epulis of the newborn is a very rare and unique tumor first described in 1871 by Neuman.
  • It is a tumor with no tendency to recur after excision.
  • We report a 2-day-old female with tumor mass on the anterior mandibular alveolar ridge, which demonstrated immunoreactivity for vimentin, S-100 and neuron-specific enolase; thus, suggesting a similar histogenesis with granular cell tumor.
  • [MeSH-minor] Diagnosis, Differential. Female. Granular Cell Tumor / diagnosis. Humans. Immunohistochemistry. Infant, Newborn. Mandible. Phosphopyruvate Hydratase / analysis. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 20657103.001).
  • [ISSN] 1998-3603
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
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18. Angeles RM, Papari M, Malecki Z: Pathologic quiz case: a 43-year-old woman with an incidentally detected posterior mediastinal mass. Granular cell tumor of the posterior mediastinum. Arch Pathol Lab Med; 2005 Jan;129(1):e27-8
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  • [Title] Pathologic quiz case: a 43-year-old woman with an incidentally detected posterior mediastinal mass. Granular cell tumor of the posterior mediastinum.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Mediastinal Neoplasms / diagnosis

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  • (PMID = 15628925.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Kurtovic S, Vikis EA, Edelstein M, Wang HL, Capiendo LM: Granular cell tumor of the transverse colon and esophagus. Am Surg; 2010 Dec;76(12):E220-1
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  • [Title] Granular cell tumor of the transverse colon and esophagus.
  • [MeSH-major] Colon, Transverse. Colonic Neoplasms / surgery. Esophageal Neoplasms / surgery. Granular Cell Tumor / pathology. Granular Cell Tumor / surgery

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  • (PMID = 21352672.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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20. Kasai K, Goto H, Osanai T: [A case of orbital granular cell tumor originating from the inferior oblique muscle]. Nippon Ganka Gakkai Zasshi; 2008 Aug;112(8):679-83
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  • [Title] [A case of orbital granular cell tumor originating from the inferior oblique muscle].
  • PURPOSE: We treated a case of orbital granular cell tumor originating from the inferior oblique muscle.
  • Imaging study results including MRI were compatible with orbital tumor.
  • The tumor was removed by an anterior approach under local anesthesia.
  • Because the tumor was continuous with the inferior oblique muscle, the inferior oblique muscle was unavoidably resected.
  • A histopathological examination showed acidophilic granulation in the cytoplasm of the tumor cells.
  • Striae of the muscle were present at the part of the tumor connecting with the inferior oblique muscle.
  • The S-100 protein test was positive for tumor cells in immunochemical staining.
  • According to these histopathological findings, a diagnosis of orbital granular cell tumor originating from the inferior oblique muscle was made.
  • CONCLUSION: Orbital granular cell tumor is known to arise from extraocular muscles, and to progress in an invasive manner.
  • When the orbital granular cell tumor is removed, pain control, vagovagal reflexes such as bradycardia, and the possibility of resection of extraocular muscles should be considered.
  • [MeSH-major] Eye Neoplasms / pathology. Granular Cell Tumor / pathology. Muscle Neoplasms / pathology. Oculomotor Muscles / pathology. Orbital Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 18767493.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 15
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21. Espinosa-de-Los-Monteros-Franco VA, Martínez-Madrigal F, Ortiz-Hidalgo C: Granular cell tumor (Abrikossoff tumor) of the thyroid gland. Ann Diagn Pathol; 2009 Aug;13(4):269-71
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  • [Title] Granular cell tumor (Abrikossoff tumor) of the thyroid gland.
  • Only 4 cases of granular cell tumor of the thyroid have been previously reported in the English literature.
  • We report herein the fifth case of this uncommon neoplasm and the first one affecting a male patient.
  • The tumor was well circumscribed and located to the left thyroid lobe, near the isthmus.
  • Histologically, the tumor was composed of large, rounded, granular eosinophilic cells that were immunohistochemically positive for S-100, calretinin, and PGP9.5 and negative for cytokeratin AE1-3, TTF-1, and thyroglobulin.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 19608086.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; EC 3.1.2.15 / UCHL1 protein, human; EC 3.1.2.15 / Ubiquitin Thiolesterase
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22. Maki DD, Horne D, Damore LJ 2nd, Jones C: Magnetic resonance appearance of granular cell tumor of the breast. Clin Imaging; 2009 Sep-Oct;33(5):395-7
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  • [Title] Magnetic resonance appearance of granular cell tumor of the breast.
  • Granular cell tumors (GCT) of the breast are rare lesions which can resemble primary breast carcinoma on clinical exam, as well as on mammographic and ultrasound imaging.
  • We describe a GCT of the breast in a 53-year-old female, with gross and microscopic pathologic correlation to the tumor's MR imaging appearance.
  • [MeSH-major] Adenocarcinoma / diagnosis. Breast Neoplasms / diagnosis. Magnetic Resonance Imaging / methods

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  • (PMID = 19712822.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Williams RW, Grave B, Stewart M, Heggie AA: Prenatal and postnatal management of congenital granular cell tumours: a case report. Br J Oral Maxillofac Surg; 2009 Jan;47(1):56-8
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  • [Title] Prenatal and postnatal management of congenital granular cell tumours: a case report.
  • Congenital granular cell tumour is a rare, benign, soft tissue lesion of the oral cavity.
  • Large or multiple lesions can cause mechanical obstruction of the oral cavity and may result in prenatal polyhydramnios, and postnatal feeding and respiratory problems.We present a case in which prenatal diagnostic imaging was used in the successful management of an infant with a large congenital granular cell tumour.
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / congenital. Granular Cell Tumor / diagnosis. Ultrasonography, Prenatal

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  • (PMID = 18556098.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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24. Rao D, Rylander H, Drees R, Schwarz T, Steinberg H: Granular cell tumor in a lumbar spinal nerve of a dog. J Vet Diagn Invest; 2010 Jul;22(4):638-42
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  • [Title] Granular cell tumor in a lumbar spinal nerve of a dog.
  • Histopathological evaluation with immunohistochemistry revealed sheets of round to polygonal cells with diffuse granular cytoplasm demonstrating diastase-resistant periodic acid-Schiff reactivity and positive immunoexpression of S100 and neuron-specific enolase.
  • Based on gross, histological, and immunohistochemical evidence, the masses were diagnosed as granular cell tumor.
  • [MeSH-major] Dog Diseases / diagnostic imaging. Granular Cell Tumor / veterinary. Spinal Cord Neoplasms / veterinary. Spinal Nerves / pathology

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  • (PMID = 20622241.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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25. Miyake M, Tateishi U, Maeda T, Arai Y, Hasegawa T, Sugimura K: Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT. Radiat Med; 2006 Feb;24(2):154-7
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  • [Title] Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT.
  • Bronchial granular cell tumor is an uncommon benign tumor that causes pulmonary complications due to obstruction of the airways.
  • [MeSH-major] Bronchial Neoplasms / complications. Granular Cell Tumor / complications. Lung Diseases, Obstructive / etiology

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  • (PMID = 16715680.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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26. Spinzi G, Fante MD, Masci E, Buffoli F, Colombo E, Fiori G, Ravelli P, Ceretti E, Minoli G, SIED Lombardia Working Group, Italy: Lack of colonic neoplastic lesions in patients under 50 yr of age with hematochezia: a multicenter prospective study. Am J Gastroenterol; 2007 Sep;102(9):2011-5
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  • RESULTS: Malignant polyps were found in two patients (0.6%), aged 30-40 yr, one in the rectum and one in the sigmoid.
  • A malignant polyp of the cecum was found in a 41-yr-old patient.
  • Another, aged 47, had a malignant granular-cell tumor of the rectum.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Gastrointestinal Hemorrhage / etiology. Rectal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Colonoscopy. Female. Humans. Intestinal Diseases / complications. Intestinal Diseases / diagnosis. Male. Middle Aged. Sigmoid Neoplasms / complications. Sigmoid Neoplasms / diagnosis

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  • (PMID = 17521401.001).
  • [ISSN] 0002-9270
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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27. Veit AC, Painter JT, Miller RA, Hardisty JF, Dixon D: Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study. Vet Pathol; 2008 Sep;45(5):654-62
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  • [Title] Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study.
  • The granular cell tumor is most often a benign neoplasm of uncertain origin.
  • Four uterine granular cell tumors in control and treated female B6C3F1 mice were identified in chronic studies at the National Toxicology Program.
  • Two tumors occurred in untreated control animals and 2 in treated animals receiving different compounds.
  • The main histomorphologic feature of tumor cells was the presence of abundant cytoplasmic eosinophilic granules that stained positive for periodic acid-Schiff with diastase resistance.
  • Tumors varied in appearance and were comprised of sheets and nests of round to polygonal cells with distinct borders.
  • Occasional multinucleated giant cells were observed.
  • Tumors were pale pink and homogeneous with trichrome stain and negative with toluidine blue.
  • Three tumors had positive to weakly positive immunoreactivity for desmin, and 1 was positive for alpha smooth muscle actin.
  • Expression of S-100, wide-spectrum cytokeratin, and neuron-specific enolase was negative for all tumors.
  • The characteristics of these uterine granular cell tumors were suggestive of a myogenic origin.
  • [MeSH-major] Granular Cell Tumor / veterinary. Uterine Neoplasms / veterinary

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  • (PMID = 18725470.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z99 ES999999
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS103826; NLM/ PMC2691646
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28. Rokunohe D, Nakano H, Oshima H, Nakajima K, Aizu T, Kaneko T, Sawamura D: Giant cutaneous granular cell tumour with papillomatous appearance. Clin Exp Dermatol; 2010 Apr;35(3):e7-9
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  • [Title] Giant cutaneous granular cell tumour with papillomatous appearance.
  • [MeSH-major] Granular Cell Tumor / pathology. Papilloma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Clavicle. Diagnosis, Differential. Humans. Male

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  • (PMID = 20500187.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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29. Iglesias A, Arias M, Santiago P, Rodríguez M, Mañas J, Saborido C: Benign breast lesions that simulate malignancy: magnetic resonance imaging with radiologic-pathologic correlation. Curr Probl Diagn Radiol; 2007 Mar-Apr;36(2):66-82
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  • The typical appearance of benign breast conditions on magnetic resonance imaging (MRI) is well established and diagnosis is usually easy.
  • However, cases of benign breast lesions that are extremely difficult to differentiate from malignant breast tumors are occasionally encountered in MRI of the breast because overlap between benign and malignant lesions characteristics is found.
  • We evaluated both enhancement kinetics and lesion morphological information to differentiate malignant from benign lesions.
  • Lesions evaluated included benign proliferative breast disease, fibroadenoma, intraductal papilloma, granular cell tumor, pseudoangiomatous stromal hyperplasia, fat necrosis, mastitis, inflammatory granuloma, epidermal inclusion cyst, and benign intramammary lymph node.
  • [MeSH-major] Breast Diseases / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Breast Cyst / diagnosis. Breast Neoplasms / diagnosis. Diagnosis, Differential. Female. Fibroadenoma / diagnosis. Granular Cell Tumor / diagnosis. Humans. Mastitis / diagnosis. Papilloma / diagnosis

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  • (PMID = 17331838.001).
  • [ISSN] 0363-0188
  • [Journal-full-title] Current problems in diagnostic radiology
  • [ISO-abbreviation] Curr Probl Diagn Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Lochan R, Balupuri S, Bennett MK, Manas DM: Granular cell tumor as an unusual cause of obstruction at the hepatic hilum: report of a case. Surg Today; 2006;36(10):934-6
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  • [Title] Granular cell tumor as an unusual cause of obstruction at the hepatic hilum: report of a case.
  • A diagnosis of malignancy is reasonably assumed when a lesion is found at the hilum or bile ducts in a patient with jaundice who has never undergone biliary surgery.
  • Although benign tumors occasionally develop in this location, preoperative recognition is difficult and most are treated as malignant lesions.
  • We illustrate this clinical scenario in this case report of a granular cell tumor (GCT) that developed at the biliary bifurcation, necessitating right hemi-hepatectomy with extrahepatic biliary tree excision.
  • We describe the clinical presentation, imaging findings, treatment, and histological findings of this tumor.
  • Although rare, a GCT can develop at the hilum and mimic a malignant lesion such as cholangiocarcinoma (CC) radiologically.
  • However, the possibility of this tumor should be considered in the differential diagnosis of a lesion in this location.
  • [MeSH-major] Bile Duct Neoplasms / complications. Cholestasis, Extrahepatic / etiology. Granular Cell Tumor / complications. Hepatic Duct, Common
  • [MeSH-minor] Cholangiography. Diagnosis, Differential. Female. Hepatectomy. Humans. Laparoscopy. Magnetic Resonance Imaging. Middle Aged

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  • (PMID = 16998691.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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31. Ensari A: Granular cell tumor: What's new in diagnosis and treatment? Turk J Gastroenterol; 2007 Sep;18(3):135-8
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  • [Title] Granular cell tumor: What's new in diagnosis and treatment?
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / surgery. Granular Cell Tumor / diagnosis. Granular Cell Tumor / surgery
  • [MeSH-minor] Diagnosis, Differential. Endoscopy, Gastrointestinal / methods. Endosonography. Humans

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  • [CommentOn] Turk J Gastroenterol. 2007 Sep;18(3):208-9 [17891699.001]
  • [CommentOn] Turk J Gastroenterol. 2007 Sep;18(3):188-91 [17891693.001]
  • (PMID = 17891685.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Comment; Editorial
  • [Publication-country] Turkey
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32. Qureshi NA, Tahir M, Carmichael AR: Granular cell tumour of the soft tissues: a case report and literature review. Int Semin Surg Oncol; 2006;3:21
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  • [Title] Granular cell tumour of the soft tissues: a case report and literature review.
  • Granular cell tumours (GCT) of the soft tissues are rare benign tumours but some time may be difficult to distinguish from malignant neoplasms.

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  • [Cites] Otolaryngol Clin North Am. 1986 Nov;19(4):659-83 [3540796.001]
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  • (PMID = 16930486.001).
  • [ISSN] 1477-7800
  • [Journal-full-title] International seminars in surgical oncology : ISSO
  • [ISO-abbreviation] Int Semin Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1560141
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33. Ayadi L, Khabir A, Fakhfakh I, Abdelmoula MH, Makni S, Sellami Boudawara T: [Granular cell tumor]. Rev Stomatol Chir Maxillofac; 2008 Jun;109(3):158-62
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  • [Title] [Granular cell tumor].
  • [Transliterated title] Tumeur à cellules granuleuses.
  • The granular cell tumor (GCT) or Abrikossoff tumor is a neurogenic tumor often benign with a predominant cervicofacial localization.
  • It is a rare tumor (0.019 to 0.03% of all tumors).
  • Nevertheless, the tumor may be mistaken for a malignant one, especially in case of shallow biopsy.
  • The neurogenic markers and staining by periodic acid Schiff (PAS) help to make the diagnosis.
  • The malignant forms with typical recurrence and metastases are extremely rare and require a wide excision.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Head and Neck Neoplasms / diagnosis
  • [MeSH-minor] Age Factors. Diagnosis, Differential. Female. Humans. Male. Prognosis. Sex Factors

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  • (PMID = 18533209.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 24
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34. Godoy G, Mufarrij PW, Tsou HC, Torre P, Taneja SS: Granular cell tumor of scrotum: a rare tumor of the male external genitalia. Urology; 2008 Sep;72(3):716.e7-9
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  • [Title] Granular cell tumor of scrotum: a rare tumor of the male external genitalia.
  • We report a rare case of granular cell tumor in the scrotum.
  • Granular cell tumors are soft-tissue neoplasms originating from Schwann cells that rarely affect male external genitalia.
  • Although never previously reported in the male external genitalia, malignant variants exist in 2% of cases.
  • Because the clinical presentation is not specific, the diagnosis of malignant granular cell tumors can be made only by the pathologist.
  • [MeSH-major] Genital Neoplasms, Male / diagnosis. Genital Neoplasms, Male / pathology. Granular Cell Tumor / diagnosis. Granular Cell Tumor / pathology. Scrotum / pathology
  • [MeSH-minor] Adolescent. Adult. Child. Humans. Male. Medical Oncology / methods. Middle Aged. Schwann Cells / pathology

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  • (PMID = 18384852.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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35. Shinohara H, Tsuchida M, Hashimoto T, Satoh S, Takeshige M, Hayashi J: Large bronchial granular cell tumor. Gen Thorac Cardiovasc Surg; 2009 Sep;57(9):484-7
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  • [Title] Large bronchial granular cell tumor.
  • We report a 20-year-old woman who underwent complete resection of a granular cell tumor (GCT).
  • Microscopically, the tumor was composed of polygonal cells with oxyphilic granular cytoplasm and small ovoid nuclei.
  • The cytoplasm of the neoplastic cells was positive for S-100 protein and neuron-specific enolase.
  • [MeSH-major] Bronchial Neoplasms / surgery. Granular Cell Tumor / surgery. Pneumonectomy

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  • [Cites] Pneumonol Alergol Pol. 2004;72(5-6):187-91 [15757256.001]
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  • (PMID = 19756937.001).
  • [ISSN] 1863-6713
  • [Journal-full-title] General thoracic and cardiovascular surgery
  • [ISO-abbreviation] Gen Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / S100 Proteins; EC 4.2.1.11 / Phosphopyruvate Hydratase
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36. De Rezende L, Lucendo AJ, Alvarez-Argüelles H: Granular cell tumors of the esophagus: report of five cases and review of diagnostic and therapeutic techniques. Dis Esophagus; 2007;20(5):436-43
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  • [Title] Granular cell tumors of the esophagus: report of five cases and review of diagnostic and therapeutic techniques.
  • Granular cell tumors (GCT) of the esophagus are stromal lesions originating from the Schwann cells of the submucosal neuronal plexus.
  • Although they are very infrequent, they constitute the second largest cause of non-epithelial tumors in the esophagus after leiomyomas.
  • These tumors are generally benign, although a certain number of malignant, aggressive cases have been reported.
  • Diagnosis requires that this possibility be ruled out before deciding on which course of therapeutic action to take as well as familiarization with the relevant indicators.
  • GCT linked synchronically or metachronically to other malignant neoplasias of the esophagus have also been described, but the actual extent of this association is uncertain.
  • The article discusses new aspects relating to the diagnosis of these lesions and the role carried out by endoscopic ultrasonography in their characterization, both at preliminary diagnosis and monitoring levels.

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  • (PMID = 17760659.001).
  • [ISSN] 1120-8694
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 30
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37. Reynders AL, Goyal P, Mortelliti AJ: Pathology quiz case. Gingival granular cell tumor of the newborn (GGCTN) (congenital epulis). Arch Otolaryngol Head Neck Surg; 2006 Jul;132(7):807-8
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  • [Title] Pathology quiz case. Gingival granular cell tumor of the newborn (GGCTN) (congenital epulis).
  • [MeSH-major] Gingival Diseases / pathology. Granuloma, Giant Cell / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant, Newborn

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  • (PMID = 16847196.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Vaos G, Zavras N, Priftis K, Pierrakos P: Bronchial granular cell tumor in a child: impact of diagnostic delay on the type of surgical resection. J Pediatr Surg; 2006 Jul;41(7):1326-8
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  • [Title] Bronchial granular cell tumor in a child: impact of diagnostic delay on the type of surgical resection.
  • Bronchial granular cell tumor is an uncommon tumor in young children.
  • Recurrent pneumonia in the same site should raise suspicion of an obstructing granular cell tumor of the bronchus.
  • We present a 10-year-old girl with an 18-month history of recurrent pneumonia caused by obstruction of the main lingular bronchus by this type of tumor.
  • In our patient, an upper left lobectomy was only technically feasible instead of a lingulectomy alone because of the spread pulmonary inflammation and the depth of bronchial wall invasion by the tumor.
  • Delayed diagnosis resulted in a more extensive pulmonary resection.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Granular Cell Tumor / diagnosis

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  • (PMID = 16818074.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Marangi GF, Toto V, Poccia I, Gigliofiorito P, Brunetti B, Persichetti P: Multiple localization of granular cell tumour: a case report. Cases J; 2009;2:8751
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  • [Title] Multiple localization of granular cell tumour: a case report.
  • INTRODUCTION: Granular cell tumour, also known as Abrikossoff's tumour, is a rare entity occurring in the skin as well as in internal organs, more common among the third to fifth decade of life.
  • It has often been described as a peripheral neuroectodermal tumour and its clinical behaviour is usually benign although malignant and multifocal forms are also known to occur.
  • CASE PRESENTATION: We report a case of multiple granular cell tumour in a 17-year-old Caucasian woman who presented with a nodular lesion in the popliteal cave, diagnosed as an Abrikossoff's Tumour, followed 2 years later by another soft tissue mass in the neck.
  • CONCLUSION: This case is quite rare: only a few cases were presented in literature with an extended period of time before the clinical presentation of subsequent disease.

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  • [Cites] Hum Pathol. 1994 Nov;25(11):1172-8 [7959661.001]
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  • (PMID = 20184692.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2827134
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40. Eghbalian F, Monsef A: Congenital epulis in the newborn, review of the literature and a case report. J Pediatr Hematol Oncol; 2009 Mar;31(3):198-9
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  • Congenital epulis (CE) is a rare tumor of the newborn, also known as granular cell tumor or congenital gingival granular cell tumor because of its histologic features.
  • Epulis is seen only in the newborn and is a different entity from other granular cell tumors.
  • Recurrences of the tumor and damage to future dentition have not been reported.
  • We report a female neonate with congenital multiple tumors in the anterior maxillary alveolar ridge and review the relevant literature.
  • The tumors were resected by surgical excision.
  • [MeSH-minor] Female. Granular Cell Tumor / congenital. Granular Cell Tumor / surgery. Humans. Infant, Newborn. Oral Surgical Procedures

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  • (PMID = 19262247.001).
  • [ISSN] 1536-3678
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Yang WT, Edeiken-Monroe B, Sneige N, Fornage BD: Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlation. J Clin Ultrasound; 2006 May;34(4):153-60
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  • [Title] Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlation.
  • PURPOSE: To describe the sonographic and mammographic appearance of granular cell tumors (GCTs) of the breast in 6 patients with pathological correlation.
  • METHODS: A search was conducted of the cyto-histopathological database in a single institution from 1990 to 2004 for breast lesions given the diagnosis of GCT of the breast.
  • The cytomorphological features of GCT included sheets of large granular cells intersected by arborizing thin-walled blood vessels.
  • The cells had round to oval nuclei, inconspicuous nucleoli, and abundant, ill-defined granular cytoplasm.
  • [MeSH-major] Breast Neoplasms / radiography. Breast Neoplasms / ultrasonography. Carcinoma / diagnosis. Granular Cell Tumor / radiography. Granular Cell Tumor / ultrasonography. Mammography. Ultrasonography, Doppler
  • [MeSH-minor] Adolescent. Adult. Age of Onset. Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] Copyright 2006 Wiley Periodicals, Inc.
  • (PMID = 16615051.001).
  • [ISSN] 0091-2751
  • [Journal-full-title] Journal of clinical ultrasound : JCU
  • [ISO-abbreviation] J Clin Ultrasound
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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42. Stranahan D, Cherpelis BS, Glass LF, Ladd S, Fenske NA: Immunohistochemical stains in Mohs surgery: a review. Dermatol Surg; 2009 Jul;35(7):1023-34
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  • BACKGROUND: During Mohs surgery, there are instances in which residual tumor cells may be difficult to detect, thereby increasing the risk of incomplete excision and tumor recurrence.
  • RESULTS: Various immunostains have proved useful in detecting tumor cells in various malignancies, including melanoma, basal cell carcinoma, squamous cell carcinoma, dermatofibrosarcoma protuberans, extramammary Paget's disease, primary cutaneous mucinous carcinoma, granular cell tumor, and trichilemmal carcinoma.
  • CONCLUSIONS: In this article, we review immunohistochemical stains that have been employed in Mohs micrographic surgery and evaluate their utility in enhancing detection of residual tumors with respect to tumor type, particularly in situations in which detection of residual tumor may be difficult.
  • [MeSH-major] Coloring Agents. Immunohistochemistry / methods. Mohs Surgery. Neoplasm, Residual / pathology. Skin Neoplasms / pathology

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  • (PMID = 19397647.001).
  • [ISSN] 1524-4725
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies; 0 / Coloring Agents
  • [Number-of-references] 45
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43. Fryssira H, Leventopoulos G, Psoni S, Kitsiou-Tzeli S, Stavrianeas N, Kanavakis E: Tumor development in three patients with Noonan syndrome. Eur J Pediatr; 2008 Sep;167(9):1025-31
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  • [Title] Tumor development in three patients with Noonan syndrome.
  • The diagnosis of Noonan syndrome is essentially clinical, based upon the distinct phenotype and the involvement of the cardiovascular system.
  • Tumor development is a rare manifestation of Noonan syndrome but can be explained by the molecular pathophysiology involved in the disorder.
  • We present three Noonan patients who developed solid tumors.
  • The first patient, a 4-year-old girl, developed granular cell tumors as did her mother in childhood.
  • The third patient, a 7-year-old boy was found to have Sertoli tumors in his right cryptorchid testis.
  • The diagnosis of Noonan syndrome was made based on distinct phenotypic findings in three patients who had different types of tumors.
  • [MeSH-major] Astrocytoma / complications. Brain Neoplasms / complications. Granular Cell Tumor / complications. Noonan Syndrome / complications. Seminoma / complications. Testicular Neoplasms / complications


44. Angiero F, Crippa R, Stefani M: Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery. Minerva Stomatol; 2006 Jul-Aug;55(7-8):423-30
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  • [Title] Granular cells tumour in the oral cavity: report of eleven cases treated with laser surgery.
  • AIM: The aim of this paper is to examine the clinical and histological feature of oral tumours of neural derivation and discuss their treatment.
  • METHODS: Between 1999 and 2004, 11 patients (6 females, 5 males; age range 28-66 years) were treated for tumours classified as being of neural origin; they were all myoblastomas or granular cells tumours (ex Abrikossoff tumour).
  • RESULTS: During follow-up, which ranged from 5 months to 5 years, there was no indication of tumour recurrence.
  • Histopathological analysis of haematoxylin and eosinstained sections showed all specimens to exhibit features typical of GCT; 6 tumours were well circumscribed, whereas 5 infiltrated adjacent connective tissue, muscle fibres and nerve bundles.
  • CONCLUSIONS: Granular cell tumour is a benign neoplasm with a tendency to relapse if not completely removed.
  • The usefulness of laser in the surgical treatment of these tumours particularly if small in size, is underlined.
  • [MeSH-major] Granular Cell Tumor / surgery. Laser Therapy. Mouth Neoplasms / surgery

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  • (PMID = 17041542.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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45. Eisenberg D, Bell R: Intraoperative endoscopy: a requisite tool for laparoscopic resection of unusual gastrointestinal lesions--a case series. J Surg Res; 2009 Aug;155(2):318-20
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  • Proper localization of small benign tumors is essential for precise non-anatomical excisions and remains difficult with the laparoscopic approach due to the greatly diminished tactile feedback.
  • Gastric lesions included pancreatic heterotopia, a gastrointestinal stromal tumor, and a Dieulafoy's lesion.
  • The cecal lesion was a granular cell tumor.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Cecal Neoplasms / pathology. Cecal Neoplasms / surgery. Female. Gastrointestinal Neoplasms / pathology. Gastrointestinal Neoplasms / surgery. Gastrointestinal Stromal Tumors / pathology. Gastrointestinal Stromal Tumors / surgery. Granular Cell Tumor / pathology. Granular Cell Tumor / surgery. Humans. Male

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  • (PMID = 19482295.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Hagert-Winkler A, Gradistanac T, Sterker I: [Abrikossoff's - granular cell tumor: intraorbital a rarity]. Rofo; 2007 Feb;179(2):171-3
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  • [Title] [Abrikossoff's - granular cell tumor: intraorbital a rarity].
  • [Transliterated title] Abrikossoff-Granularzelltumor: intraorbital eine Rarität.
  • [MeSH-major] Granular Cell Tumor. Orbital Neoplasms
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Intraocular Pressure. Magnetic Resonance Imaging. Male. Oculomotor Muscles. Time Factors

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  • (PMID = 17318993.001).
  • [ISSN] 1438-9029
  • [Journal-full-title] RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
  • [ISO-abbreviation] Rofo
  • [Language] ger
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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47. Elakkumanan LB, Chhabra A, Bose S, Sharma K: Granular cell myoblastoma of tongue: a rare cause of unanticipated difficult intubation. Middle East J Anaesthesiol; 2010 Feb;20(4):573-6
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  • [Title] Granular cell myoblastoma of tongue: a rare cause of unanticipated difficult intubation.
  • We report a case of granular cell myoblastoma of the tongue, as a cause of an unanticipated impossible intubation.
  • [MeSH-major] Granular Cell Tumor / pathology. Intubation, Intratracheal / methods. Neoplasms, Muscle Tissue / pathology. Tongue Neoplasms / pathology

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  • (PMID = 20394257.001).
  • [ISSN] 0544-0440
  • [Journal-full-title] Middle East journal of anaesthesiology
  • [ISO-abbreviation] Middle East J Anaesthesiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Lebanon
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48. Halum SL, Yates C: Granular cell tumor of the esophagus presenting as a duplication cyst. Ear Nose Throat J; 2008 Mar;87(3):135
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  • [Title] Granular cell tumor of the esophagus presenting as a duplication cyst.
  • [MeSH-major] Deglutition Disorders / etiology. Esophageal Cyst / pathology. Esophageal Neoplasms / pathology. Esophagus / pathology. Granular Cell Tumor / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 18404906.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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49. Sasaki T, Yamamoto K, Akashi T: Granular cell tumour arising from the Kiesselbach's area of the nasal septum. J Laryngol Otol; 2007 Feb;121(2):170-3
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  • [Title] Granular cell tumour arising from the Kiesselbach's area of the nasal septum.
  • An extremely rare case of a granular cell tumour arising from the right Kiesselbach's area (Little's area) of the nasal septum is reported.
  • During surgery, the tumour shrank markedly following local application of adrenaline, suggestive of hypervascularity.
  • The tumour was successfully excised by careful dissection after cauterisation of the mucosa surrounding the tumour.
  • Histopathological examination revealed morphological features of granular cell tumour immunopositive for S-100 protein.
  • This is the first report of granular cell tumour arising from the Kiesselbach's area in the English literature.
  • The eccentric behaviour of the tumour and the management of a granular cell tumour arising from this area are discussed, together with a literature review.
  • [MeSH-major] Granular Cell Tumor / pathology. Nasal Septum / pathology. Nose Neoplasms / pathology

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  • (PMID = 17059623.001).
  • [ISSN] 1748-5460
  • [Journal-full-title] The Journal of laryngology and otology
  • [ISO-abbreviation] J Laryngol Otol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 12
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50. Torre M, Yankovic F, Herrera O, Borel C, Latorre JJ, Aguilar P, Varela P: Granular cell tumor mimicking a subglottic hemangioma. J Pediatr Surg; 2010 Dec;45(12):e9-11
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  • [Title] Granular cell tumor mimicking a subglottic hemangioma.
  • Pediatric airway tumors are uncommon.
  • Complete tumor resection by open approach was undertaken.
  • Histopathologic and immunohistochemical studies revealed granular cells tumor.
  • The similarity of the clinical and endoscopic presentation of this tumor to the much more frequent subglottic hemangioma that usually requires a different therapeutic approach was of interest.
  • Granular cell tumor must be considered in the differential diagnosis of upper airway obstructive symptoms in infancy and childhood.
  • [MeSH-major] Airway Obstruction / etiology. Granular Cell Tumor / diagnosis. Hemangioma / diagnosis. Laryngeal Neoplasms / diagnosis. Laryngitis / etiology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Child, Preschool. Cricoid Cartilage / pathology. Diagnosis, Differential. Female. Humans. Laryngoscopy. Laryngostenosis / etiology. Laryngostenosis / surgery. Neoplasm Proteins / analysis. Respiratory Sounds / etiology. S100 Proteins / analysis

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21129532.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Neoplasm Proteins; 0 / S100 Proteins
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51. Hung KC, Chu YH, Lin YS: Granular cell tumor of the hypopharynx. Otolaryngol Head Neck Surg; 2008 Apr;138(4):533-4
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  • [Title] Granular cell tumor of the hypopharynx.
  • [MeSH-major] Granular Cell Tumor / surgery. Hypopharyngeal Neoplasms / surgery

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  • (PMID = 18359369.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / S100 Proteins
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52. Hsu JL, Su CY, Lin JW: Resection of a granular cell tumor of the larynx followed by medialization laryngoplasty with bipedicled sternohyoid muscle transposition. Otolaryngol Head Neck Surg; 2006 Dec;135(6):983-5
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  • [Title] Resection of a granular cell tumor of the larynx followed by medialization laryngoplasty with bipedicled sternohyoid muscle transposition.
  • [MeSH-major] Glottis / surgery. Granular Cell Tumor / surgery. Laryngeal Neoplasms / surgery

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  • (PMID = 17141103.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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53. Kapur P, Rakheja D, Balani JP, Roy LC, Amirkhan RH, Hoang MP: Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors. Arch Pathol Lab Med; 2007 Jan;131(1):57-64
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  • [Title] Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors.
  • CONTEXT: Granular cell tumors (GCTs) are classified as benign when none of the following features is present: spindling of the tumor cells, necrosis, diffuse pleomorphism, prominent nucleoli, high nuclear-cytoplasmic ratio, and mitotic rate >2 per 10 high-power fields.
  • It has been suggested that a GCT be classified as atypical when 1 or 2 of these features are seen and as malignant when 3 or more of these are present.
  • In our practice, we do not classify GCTs as malignant in the absence of metastasis.
  • The number of positive cells for Ki-67, p21, and PHH3 was calculated in 10 consecutive high-power fields in a hot spot.
  • [MeSH-major] Caspase 3 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Fatty Acid Synthases / metabolism. Granular Cell Tumor / metabolism. Histones / metabolism. Ki-67 Antigen / metabolism. Soft Tissue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy. Diagnosis, Differential. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry / methods. Male. Middle Aged. Mitosis. Necrosis / pathology. Phosphorylation. Retrospective Studies

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  • (PMID = 17227124.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Histones; 0 / Ki-67 Antigen; EC 2.3.1.85 / Fatty Acid Synthases; EC 3.4.22.- / Caspase 3
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54. Narra SL, Tombazzi C, Datta V, Ismail MK: Granular cell tumor of the esophagus: report of five cases and review of the literature. Am J Med Sci; 2008 May;335(5):338-41
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  • [Title] Granular cell tumor of the esophagus: report of five cases and review of the literature.
  • Granular cell tumor (GCT) is an uncommon esophageal neoplasm.
  • Diagnosis can be made by endoscopic biopsy in most cases.
  • [MeSH-major] Esophageal Neoplasms / pathology. Granular Cell Tumor / pathology

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  • (PMID = 18480648.001).
  • [ISSN] 0002-9629
  • [Journal-full-title] The American journal of the medical sciences
  • [ISO-abbreviation] Am. J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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55. Nagaraj PB, Ongole R, Bhujanga-Rao BR: Granular cell tumor of the tongue in a 6-year-old girl--a case report. Med Oral Patol Oral Cir Bucal; 2006 Mar;11(2):E162-4
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  • [Title] Granular cell tumor of the tongue in a 6-year-old girl--a case report.
  • Granular cell tumor is a relatively uncommon benign hamartomatous lesion occurring in almost any part of the body.
  • Granular cell lesions may be found in other diverse sites such as the jaw, skin, gastro intestinal tract and respiratory tract.
  • However, histochemical and ultra structural studies propose the origin of the lesion from schwann cells, striated muscle, mesenchymal cells, histiocytes and epithelial cells.
  • The tumor generally occurs in middle or older aged adults.
  • As most of the granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • We describe a case of granular cell tumor of the tongue in a 6 year old girl along with a brief review of literature on granular cell tumors.
  • [MeSH-major] Granular Cell Tumor. Tongue Neoplasms

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  • (PMID = 16505796.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 15
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56. Klopp LS, Ridgway M: Use of an endoscope in minimally invasive lesion biopsy and removal within the skull and cranial vault in two dogs and one cat. J Am Vet Med Assoc; 2009 Jun 15;234(12):1573-7
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  • Two dogs underwent endoscopic surgery procedures; 1 dog underwent removal of an intranasal dermoid cyst with extension to the olfactory bulb dura, and the other underwent lesion biopsy for histologic confirmation of suspected intracranial granular cell tumor.
  • CLINICAL RELEVANCE- In human and veterinary neurosurgery, minimally invasive surgical approaches for diagnosis and treatment are gaining in popularity.

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  • (PMID = 19527133.001).
  • [ISSN] 0003-1488
  • [Journal-full-title] Journal of the American Veterinary Medical Association
  • [ISO-abbreviation] J. Am. Vet. Med. Assoc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Yanagawa N, Sasou S, Sato T, Shiono S, Kato H: [Mediastinal granular cell tumor: report of a case]. Kyobu Geka; 2006 May;59(5):418-21
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  • [Title] [Mediastinal granular cell tumor: report of a case].
  • Mediastinal granular cell tumor is rare.
  • We report a case of 16-year-old woman with a granular cell tumor in the right upper-middle mediastinum.
  • Tumor resection was performed.
  • It was found that the tumor involved right vagus nerve.
  • The tumor was completely excised with combined resection of the right vagus nerve peripheral to the right recurrent nerve.
  • Histopathologically, the tumor consisted of round to polygonal cells with abundant eosinophilic granular cytoplasm, and diagnosed a granular cell tumor.
  • [MeSH-major] Granular Cell Tumor / surgery. Mediastinal Neoplasms / surgery

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  • (PMID = 16715895.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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58. Lowe DL, Chaudhary AJ, Lee JR, Chamberlain SM, Schade RR, Cuartas-Hoyos U: Four cases of patients with gastrointestinal granular cell tumors. South Med J; 2007 Mar;100(3):298-300
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  • [Title] Four cases of patients with gastrointestinal granular cell tumors.
  • We present four cases of gastrointestinal granular cell tumors (GCT) with a literature review.
  • Gastrointestinal granular cell tumors, a benign neural tumor thought to arise from Schwann cells, can occur in several areas, including the gastrointestinal tract.
  • GCTs are malignant less than 2% of the time.
  • Although most GCTs are benign and can be followed endoscopically without resection, the malignant potential warrants evaluation with endoscopic ultrasound for possible endoscopic or surgical resection.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Esophageal Neoplasms / diagnosis. Granular Cell Tumor / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 17396735.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 23
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59. Ilvan S, Ustündağ N, Calay Z, Bükey Y: Benign granular-cell tumour of the breast. Can J Surg; 2005 Apr;48(2):155-6
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  • [Title] Benign granular-cell tumour of the breast.
  • [MeSH-major] Breast Neoplasms / surgery. Granular Cell Tumor / surgery

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  • [Cites] Cytopathology. 1999 Dec;10(6):383-9 [10607009.001]
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  • (PMID = 15887799.001).
  • [ISSN] 0008-428X
  • [Journal-full-title] Canadian journal of surgery. Journal canadien de chirurgie
  • [ISO-abbreviation] Can J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Other-IDs] NLM/ PMC3211608
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60. White JB, Glade R, Rossi CT, Bielamowicz S: Granular cell tumors of the larynx: diagnosis and management. J Voice; 2009 Jul;23(4):516-7
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  • [Title] Granular cell tumors of the larynx: diagnosis and management.
  • In this case study, a retrospective review of chart and literature was done to discuss the presentation and treatment of granular cell tumors of the larynx.
  • One patient was diagnosed and treated successfully with surgical resection of a laryngeal granular cell tumor.
  • Granular cell tumors should be considered in the differential diagnosis of laryngeal masses, particularly in the posterior glottis.
  • [MeSH-major] Granular Cell Tumor / diagnosis. Granular Cell Tumor / therapy. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / therapy
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Larynx / pathology. Larynx / surgery. Recovery of Function. Treatment Outcome. Voice

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  • (PMID = 18346870.001).
  • [ISSN] 1873-4588
  • [Journal-full-title] Journal of voice : official journal of the Voice Foundation
  • [ISO-abbreviation] J Voice
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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61. Lauwers K, Bestman TJ, Bergmans G, Molderez C: Granular cell tumour of the male breast. Acta Chir Belg; 2008 Jan-Feb;108(1):112-4
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  • [Title] Granular cell tumour of the male breast.
  • Granular cell tumour (GCT) is a rare neoplasm that can be found in multiple sites throughout the body.
  • In general, it appears as a singular benign lesion, although it can be multi-focal and rare cases with malignant behaviour have been reported.
  • We report a rare case of granular cell tumour of the nipple in the male breast, treated by wide local excision.
  • [MeSH-major] Breast Neoplasms, Male / surgery. Granular Cell Tumor / surgery

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  • (PMID = 18411585.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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62. Kobayashi TK, Bamba M, Oka H, Hino A, Fujimoto M, Katsumori T, Moritani S, Kushima R, Kaneko C: Granular cell tumour of the neurohypophysis on cytological squash preparations. Cytopathology; 2006 Jun;17(3):153-4
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  • [Title] Granular cell tumour of the neurohypophysis on cytological squash preparations.
  • [MeSH-major] Granular Cell Tumor / pathology. Pituitary Gland, Posterior / pathology. Pituitary Neoplasms / pathology

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  • (PMID = 16719859.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / May-Grunwald Giemsa; T42P99266K / Methylene Blue; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
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63. Fang HY, Wu CY, Huang HJ, Lin YM: Granular cell tumor of the lung. Lung; 2010 Aug;188(4):355-7
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  • [Title] Granular cell tumor of the lung.
  • A thoracoscopic RML lobectomy was then performed and immunohistochemical study and Ki-67 proliferative index on the pathology sample demonstrated a benign granular cell tumor.
  • Thirty-six months after surgery, the patient remains symptom-free and there has been no recurrence of the tumor on follow-up CT scan.
  • [MeSH-major] Granular Cell Tumor / diagnostic imaging. Lung Neoplasms / diagnostic imaging

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  • [Cites] Pediatr Pulmonol. 2000 Nov;30(5):425-8 [11064434.001]
  • [Cites] South Med J. 2005 Oct;98(10):1034-5 [16295820.001]
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  • (PMID = 20066540.001).
  • [ISSN] 1432-1750
  • [Journal-full-title] Lung
  • [ISO-abbreviation] Lung
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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64. Ohta T, Yachi K, Ogino A, Yokoyama T, Fukushima T, Watanabe T, Yoshino A, Katayama Y, Honma T, Sugitani M: Pleomorphic granular cell astrocytoma in the pineal gland: case report. Neuropathology; 2010 Dec;30(6):615-20
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  • [Title] Pleomorphic granular cell astrocytoma in the pineal gland: case report.
  • Pleomorphic granular cell astrocytoma in the pineal region is exceedingly rare, and its clinicopathological features are distinctive.
  • Following surgery, pathological examinations demonstrated a pleomorphic granular cell astrocytoma.
  • Variability was also observed in the eosinophilic granular bodies, Rosenthal fibers and spindle-shaped tumor cells.
  • Reticulin network was absent between the tumor cells, and granular cells with ballooned cytoplasm showing positive staining for PAS.
  • Pleomorphic granular cell astrocytoma is believed to be a form of astrocytoma originating from the pineal gland.
  • However, it can be differentiated from the latter by the absence of reticulin fibers, absence of basement membrane between adjacent cells, and presence of large numbers of mitochondria.

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  • [Copyright] © 2010 Japanese Society of Neuropathology.
  • (PMID = 20113405.001).
  • [ISSN] 1440-1789
  • [Journal-full-title] Neuropathology : official journal of the Japanese Society of Neuropathology
  • [ISO-abbreviation] Neuropathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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65. Weinreb I, Bray P, Ghazarian D: Plexiform intraneural granular cell tumour of a digital cutaneous sensory nerve. J Clin Pathol; 2007 Jun;60(6):725-6
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  • [Title] Plexiform intraneural granular cell tumour of a digital cutaneous sensory nerve.
  • [MeSH-major] Fingers / innervation. Granular Cell Tumor / pathology. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 17557873.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1955072
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66. Schittenhelm J, Ebner FH, Harter P, Bornemann A: Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol; 2009;20(1):73-7
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  • Benign epithelial tumors are rarely found at this site.
  • The excised tumor was composed of nests of large polygonal cells with eosinophilic partial granular cytoplasm.
  • The tumor showed diffuse positivity for melan-A, synaptophysin, and alpha-inhibin.
  • Ultrastructural examination showed abundant mitochondria, suggesting an oncocytic tumor.
  • The diagnosis of an oncocytic adrenal cortical adenoma was made.
  • These extraadrenal tumors are thought to arise from heterotopic adrenocortical tissue in the spinal cavity.
  • Oncocytic tumors are rare neoplasms and they comprise non-functioning variants of adrenal cortical adenomas.
  • To date, only five such intraspinal tumors have been observed.
  • Immunohistochemistry excluded oncocytic paraganglioma, oncocytic meningioma, renal cell carcinoma, alveolar soft part sarcoma, and granular cell tumor.
  • A view of the literature of these rare but probably underdiagnosed intraspinal tumors is given.

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  • (PMID = 19039533.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Chang SM, Wei CK, Tseng CE: The cytology of a thyroid granular cell tumor. Endocr Pathol; 2009;20(2):137-40
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  • [Title] The cytology of a thyroid granular cell tumor.
  • Granular cell tumor (GCT) of the thyroid is rare.
  • The tumor cells were single, in syncytial clusters, or pseudofollicles, contained small round, oval, or spindle nuclei, indistinct nucleoli, and a large amount of grayish, granular fragile cytoplasm.
  • The background contained granular debris and naked nuclei.
  • A differential diagnosis of thyroid GCT with more frequent thyroid lesions containing cytoplasmic granules, including Hurthle cells, macrophages, follicular cells, and cells of black thyroid syndrome, was also performed.
  • [MeSH-major] Granular Cell Tumor / pathology. Thyroid Neoplasms / pathology
  • [MeSH-minor] Biopsy, Fine-Needle / methods. Child. Diagnosis, Differential. Female. Humans. Macrophages / pathology. Oxyphil Cells / pathology

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  • (PMID = 19352601.001).
  • [ISSN] 1046-3976
  • [Journal-full-title] Endocrine pathology
  • [ISO-abbreviation] Endocr. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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68. Braga-Tavares H, Santos H, M-Pinto I, Ramos M, de Sousa P: [Congenital epulis]. Cir Pediatr; 2009 Jan;22(1):49-51
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  • Congenital epulis or gingival granular cell tumor is an uncommon benign tumor, usually diagnosed at birth as a pediculated maxilar gingival mass.

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  • (PMID = 19323084.001).
  • [ISSN] 0214-1221
  • [Journal-full-title] Cirugía pediátrica : organo oficial de la Sociedad Española de Cirugía Pediátrica
  • [ISO-abbreviation] Cir Pediatr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 28
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69. Bayan K, Yilmaz S, Tüzün Y, Can A, Büyükbayram H: Granular cell tumor of the esophagus and its endoscopic treatment. Turk J Gastroenterol; 2007 Sep;18(3):208-9
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  • [Title] Granular cell tumor of the esophagus and its endoscopic treatment.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Esophageal Neoplasms / surgery. Esophagoscopy. Granular Cell Tumor / diagnosis. Granular Cell Tumor / surgery
  • [MeSH-minor] Adult. Deglutition Disorders / etiology. Diagnosis, Differential. Humans. Male. Papilloma / diagnosis

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  • [CommentIn] Turk J Gastroenterol. 2007 Sep;18(3):135-8 [17891685.001]
  • (PMID = 17891699.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Turkey
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70. Rhee DY, Lee HW, Chung WK, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK: Giant dermatofibroma with granular cell changes: side-effect of bee-venom acupuncture? Clin Exp Dermatol; 2009 Jul;34(5):e18-20
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  • [Title] Giant dermatofibroma with granular cell changes: side-effect of bee-venom acupuncture?
  • Dermatofibroma (DF) is a common benign fibrohistiocytic tumour with a predilection for the legs in middle-aged women.
  • Granular cell change is typical of granular cell tumour, but can be observed in diverse cell lineages.
  • We describe a 49-year-old Korean man with a giant DF showing granular cell differentiation, which may have been caused in part by multiple treatments with bee-venom acupuncture.

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  • (PMID = 19486038.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bee Venoms
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71. Zhuang YZ, Jiang XY, Chen PQ: [Malignant granular cell tumor of the urinary bladder]. Zhonghua Bing Li Xue Za Zhi; 2006 Mar;35(3):188
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  • [Title] [Malignant granular cell tumor of the urinary bladder].
  • [MeSH-major] Granular Cell Tumor / pathology. Urinary Bladder Neoplasms / pathology

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  • (PMID = 16630515.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
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72. John BK, Dang NC, Hussain SA, Yang GC, Cham MD, Yantiss R, Joseph AS, Giashuddin SM, Lee PC, Fleming R, Somnay K: Multifocal granular cell tumor presenting as an esophageal stricture. J Gastrointest Cancer; 2008;39(1-4):107-13
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  • [Title] Multifocal granular cell tumor presenting as an esophageal stricture.
  • INTRODUCTION: Granular cell tumors are uncommonly found in the gastrointestinal tract with slow progression and are usually benign though they may have propensity for malignant transformation.
  • Initially attributed to neuronal origin through immunohistochemistry, there has been controversy with increasing reports of granular cell tumors of non-neural origin.
  • CASE REPORT: We report a case of multifocal granular cell tumor involving the esophagus and stomach in a young female with history of dysphagia for 9 years with worsening symptoms.
  • Fine-needle aspiration (FNA) showed large cells with granular cytoplasm along with spindle nuclei.
  • Cells were initially checked for CD117 stain alone and found to be negative.
  • A follow-up CT-guided core needle biopsy revealed similar granular cells that were positive for S-100.
  • She underwent a two-stage transhiatal esophagogastrectomy as the tumor circumferentially involved the cervical esophagus and was adherent to the trachea and recurrent laryngeal nerve bilaterally.
  • DISCUSSION AND CONCLUSION: As these tumors may have potential for malignant transformation and locoregional invasion, they should be considered while evaluating submucosal lesions of the esophagus even in young patients.
  • A large number of granular cell tumors may be missed in the absence of S-100 staining, which should be requested when granular cells are seen on cytology obtained by EUS FNA as this can be a minimally invasive diagnostic modality for these tumors.
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Esophageal Stenosis / etiology. Granular Cell Tumor / diagnosis. Stomach Neoplasms / diagnosis

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  • (PMID = 19340612.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Lach B, Kanaan I: Granular cell meningioma. A case report. Folia Neuropathol; 2007;45(1):19-22
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  • [Title] Granular cell meningioma. A case report.
  • We describe a granular cell tumour developing in clear cell meningioma of the falx.
  • Granular and clear cells showed immunoreactivity for vimentin, epithelial membrane antigen and progesterone receptors.
  • This is the first case documenting arachnoid origin of neoplastic granular cells in meningioma.

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  • (PMID = 17357006.001).
  • [ISSN] 1641-4640
  • [Journal-full-title] Folia neuropathologica
  • [ISO-abbreviation] Folia Neuropathol
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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74. Cuevas J, de Eusebio E, Diez E, Castiñeira I: [Mohs micrographic surgery: aplication of this technique to penile neoplasms]. Actas Urol Esp; 2007 Oct;31(9):1076-81
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  • [Transliterated title] Cirugía de Mohs: aplicación de la técnica a neoplasias del pene.
  • That is possible because Mohs surgery provides the advantage of microscopically controlled tumor-free borders in each stage guiding the surgeon in the tumor persistence until the complete surgical excision.
  • Although infrequent, other penile neoplasms that can benefit from Mohs micrographic surgery are: basal cell carcinoma, extrammamary Paget's disease, in situ melanoma and granular cell tumor.

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  • (PMID = 18257374.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 17
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75. Arican O, Ciralik H, Sasmaz S: Multiple plaques on the back: S-100 negative benign granular cell tumor. J Dermatol; 2005 Jul;32(7):585-8
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  • [Title] Multiple plaques on the back: S-100 negative benign granular cell tumor.
  • Granular cell tumor is a rarely seen disease characterized by a gradually developing nodular lesion, which is difficult to diagnose.
  • It has been thought to originate from Schwann cells.
  • The tumor usually appears in the 4th-6th decades of life, more frequently in women and blacks, and has a multifocal location in 10-25% of the cases.
  • The present paper describes an 18-year-old female patient with benign granular cell tumor.
  • This rarely seen type of tumor was S-100 negative and has been detected in biopsies taken from multiple asymptomatic plaques and maculopapular lesions.
  • [MeSH-major] Granular Cell Tumor / pathology. S100 Proteins / analysis. Skin Neoplasms / pathology

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  • (PMID = 16335876.001).
  • [ISSN] 0385-2407
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / S100 Proteins
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76. Kondi-Pafiti A, Kairi-Vassilatou E, Liapis A, Bakalianou K, Iavazzo Ch, Hasiakos D: Granular cell tumor of the female genital system. Clinical and pathologic characteristics of five cases and literature review. Eur J Gynaecol Oncol; 2010;31(2):222-4
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  • [Title] Granular cell tumor of the female genital system. Clinical and pathologic characteristics of five cases and literature review.
  • The clinical and pathological characteristics of a rare granular cell tumor that developed in the vulva (4 cases) and the breast (1 case) offive women aged 35-52 years are reported.
  • The differential diagnosis from skin carcinomas, melanoma and various soft tissue tumors is emphasized.
  • [MeSH-major] Breast Neoplasms / pathology. Granular Cell Tumor / pathology. Vulvar Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged. Prognosis. Treatment Outcome

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  • (PMID = 20527248.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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77. Yoon Y, Curry K: Concurrence of granular cell tumor and Mycobacterium tuberculosis. South Med J; 2005 Oct;98(10):1034-5
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  • [Title] Concurrence of granular cell tumor and Mycobacterium tuberculosis.
  • Granular cell tumors (GCT) are rare, usually benign neoplasms of Schwann cell origin.
  • This report reviews the literature regarding GCT and presents this unusual case of granular cell tumor co-occurring with active tuberculosis.
  • [MeSH-major] Granular Cell Tumor / complications. Tuberculosis / complications

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  • (PMID = 16295820.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antitubercular Agents; 2KNI5N06TI / Pyrazinamide; 8G167061QZ / Ethambutol; V83O1VOZ8L / Isoniazid; VJT6J7R4TR / Rifampin
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78. Kourda N, Ferchichi L, Sayari S, Ben Moussa M, Zaouche A, Ben Jilani SB, Zermani R: [Multifocal granular cell tumor of colon: a rare location]. Tunis Med; 2008 Nov;86(11):1021-2
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  • [Title] [Multifocal granular cell tumor of colon: a rare location].
  • [Transliterated title] Tumeur à cellules granuleuses multifocale du colon: une localisation inhabituelle.
  • [MeSH-major] Colonic Neoplasms / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology

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  • (PMID = 19213503.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Tunisia
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79. Kim YD, Kim HJ, Lee NK, Ha WH, Lee CH, Park SE: Congenital epulis: prenatal ultrasonographic and postnatal MR features with pathologic correlation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Nov;106(5):743-8
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  • Histologic examination revealed a congenital granular cell tumor with prominent peripheral vessels.
  • [MeSH-major] Gingival Neoplasms / pathology. Gingival Neoplasms / ultrasonography. Granular Cell Tumor / pathology. Granular Cell Tumor / ultrasonography. Ultrasonography, Prenatal

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  • (PMID = 18424116.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Andrade ES, Filho JR, Rocha NS, Neto IC, Camargo IB: Isolated intra-oral granular cell tumor: report of two cases and review of the literature. Acta Odontol Latinoam; 2010;23(2):99-104
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  • [Title] Isolated intra-oral granular cell tumor: report of two cases and review of the literature.
  • Granular cell tumor (GCT) is a relatively uncommon lesion occurring in almost any part of the body, including the orofacial region.
  • Although aggressive and malignant variants of this neoplasm have been described, most GCTs are benign.
  • However, histochemical and ultra-structural studies propose the origin of the lesion from Schwann cells, striated muscle, mesenchymal cells, histiocytes and epithelial cells.
  • The tumor generally occurs in middle-aged or older adults.
  • As most granular cell tumors are benign, surgical excision of the lesion is the treatment of choice.
  • Differential diagnoses include fibrous hyperplasia, minor salivary gland tumor condyloma acuminatum and neurilemmoma.
  • The main clinical pathology and diagnostic features of this neoplasm are reviewed and discussed.
  • [MeSH-major] Granular Cell Tumor / pathology. Tongue Neoplasms / pathology

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  • (PMID = 21053681.001).
  • [ISSN] 0326-4815
  • [Journal-full-title] Acta odontológica latinoamericana : AOL
  • [ISO-abbreviation] Acta Odontol Latinoam
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Argentina
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81. Hong R, Lim SC: Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report. World J Gastroenterol; 2009 Jul 14;15(26):3315-8
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  • [Title] Granular cell tumor of the cecum with extensive hyalinization and calcification: a case report.
  • A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that is generally believed to be of nerve sheath origin.
  • In addition to the tumor, endoscopic examination revealed the presence of a 5-mm-polyp in the descending colon and multiple tiny polyps in the sigmoid colon and rectum.
  • Histological examination demonstrated a cecal tumor 1.5 cm x 1.0 cm x 0.7 cm with a hard consistency; in cut sections, mixed cells with yellowish and whitish portions were seen.
  • The tumor was located between the mucosa and subserosa, and was composed of plump histiocyte-like tumor cells with abundant granular eosinophilic cytoplasm, which were immunoreactive for S-100 protein, vimentin, neuron-specific enolase, inhibin-alpha and calretinin.
  • The tumor showed extensive hyalinization and focal dystrophic calcification.
  • Immunohistochemical profiles did not confirm any particular cell type for the histogenetic origin of the GCT, including a nerve sheath origin.
  • Extensive hyalinization and calcification showing involution of tumor cells suggest benign clinical behavior of GCT.
  • [MeSH-major] Calcinosis / pathology. Cecum / pathology. Granular Cell Tumor / pathology. Hyalin / metabolism
  • [MeSH-minor] Biomarkers, Tumor. Calbindin 2. Colorectal Neoplasms / diagnosis. Colorectal Neoplasms / pathology. Humans. Male. Middle Aged. Phosphopyruvate Hydratase. S100 Calcium Binding Protein G. S100 Proteins. Vimentin

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  • [Cites] Ugeskr Laeger. 2006 May 22;168(21):2080-1 [16768929.001]
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  • (PMID = 19598311.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CALB2 protein, human; 0 / Calbindin 2; 0 / S100 Calcium Binding Protein G; 0 / S100 Proteins; 0 / Vimentin; EC 4.2.1.11 / Phosphopyruvate Hydratase
  • [Other-IDs] NLM/ PMC2710791
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82. Woosley JT, Grimm I: Granular-cell tumor of the duodenum: a case report. Gastrointest Endosc; 2006 Feb;63(2):339-41
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  • [Title] Granular-cell tumor of the duodenum: a case report.
  • [MeSH-major] Duodenal Neoplasms / diagnosis. Granular Cell Tumor / diagnosis
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Endoscopy, Gastrointestinal. Endosonography. Female. Follow-Up Studies. Humans

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  • (PMID = 16427953.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Feller L, Wood NH, Singh AS, Raubenheimer EJ, Meyerov R, Lemmer J: Multiple congenital oral granular cell tumours in a newborn black female: a case report. Cases J; 2008;1(1):13
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  • [Title] Multiple congenital oral granular cell tumours in a newborn black female: a case report.
  • INTRODUCTION: Congenital oral granular cell tumour of the newborn is an uncommon benign tumour of uncertain origin.
  • Microscopic examination of the lesions showed densely packed round to oval cells with abundant granular eosinophilic cytoplasm and uniform nuclei.
  • The diagnosis was congenital granular cell tumour.
  • CONCLUSION: Congenital oral granular cell tumour occurs almost exclusively in Caucasian newborns but also rarely in black infants.

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  • (PMID = 18577259.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2438317
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84. Lang SM, Specht D, Hecker E, Ortmann J: [Granular cell tumour in a patient with pulmonary tuberculosis]. Pneumologie; 2008 Mar;62(3):158-61
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  • [Title] [Granular cell tumour in a patient with pulmonary tuberculosis].
  • Primary tracheal tumours are rare and often only cause symptoms at a late stage, when the tumour obstructs most of the tracheal lumen.
  • We report the case of a 45-year-old woman with pulmonary tuberculosis and a tumour in the trachea, which had been interpreted as a tuberculous lymph node perforating the tracheal wall.
  • Bronchoscopy revealed a white, glossy, papillomatous lesion in the ventral wall of the trachea, which was identified by histology as a granular cell tumour.
  • After culture conversion of the underlying tuberculosis, which led to the detection of the lesion, the tumour was surgically removed.
  • Granular cell tumours rarely appear in the trachea, they may be multifocal and sometimes follow a malignant course.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 18200457.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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85. Terada T: Benign Tumors of the Esophagus: A Histopathologic Study of 49 Cases among 931 Consecutive Esophageal Biopsies. Gastroenterology Res; 2009 Apr;2(2):100-103
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  • [Title] Benign Tumors of the Esophagus: A Histopathologic Study of 49 Cases among 931 Consecutive Esophageal Biopsies.
  • : The author reviewed 931 consecutive esophageal biopsies in the last 15 year in out pathology laboratory of our hospital in search for benign esophageal tumors.
  • As the results, 41 cases (4.4%) of squamous papilloma, 4 cases (0.4%) of granular cell tumor, 3 cases (0.3%) of leiomyoima, and 1 case (0.1%) tubular adenoma were identified.
  • It was endoscopically recognized as small polypoid tumor.
  • The 4 cases of granular cell tumor were located in the proximal esophagus in 3 cases, and in the middle esophagus in 1 case.
  • The granular cell tumor was immunohistochemically positive for vimentin, S100 protein, and neuron-specific enolase.
  • It was endoscopically recognized as a submucosal tumor.

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  • (PMID = 27956961.001).
  • [ISSN] 1918-2805
  • [Journal-full-title] Gastroenterology research
  • [ISO-abbreviation] Gastroenterology Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Benign tumor / Clinicopathology / Esophagus / Immunohistochemistry
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86. Loncar B, Marjanović K, Pauzar B, Staklenac B: Granular cell tumor--clinically presented as lymphadenopathy. Coll Antropol; 2010 Mar;34(1):261-3
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  • [Title] Granular cell tumor--clinically presented as lymphadenopathy.
  • Granular cell tumors are relatively uncommon benign lesions occurring in almost any part of the body.
  • We report the cytological diagnosis of granular cell tumor in 25-year-old male patient who presented with an inguinal mass clinically suspected to be a lymphadenopathy.
  • Fine needle aspiration revealed polygonal cells with abundant, granular cytoplasm and eccentrically located vesicular nuclei and inconspicuous nucleoli.
  • The histopathological examination of the surgical excision confirmed the diagnosis.
  • If resection is complete, local surgical excision is curative for benign granular cell tumors.
  • Granular cell tumor has a characteristic cytological appearance, and fine-needle aspiration cytology has been suggested to be diagnostic modality of choice.
  • [MeSH-major] Biopsy, Fine-Needle. Granular Cell Tumor / pathology. Lymphatic Diseases / pathology. Neoplasms / pathology

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  • (PMID = 20432759.001).
  • [ISSN] 0350-6134
  • [Journal-full-title] Collegium antropologicum
  • [ISO-abbreviation] Coll Antropol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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87. Blacksin MF, White LM, Hameed M, Kandel R, Patterson FR, Benevenia J: Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation. Skeletal Radiol; 2005 Oct;34(10):625-31
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  • [Title] Granular cell tumor of the extremity: magnetic resonance imaging characteristics with pathologic correlation.
  • OBJECTIVE: The purpose of this study is to delineate the magnetic resonance (MR) appearance of a granular cell tumor (GrCT) of the extremity and to correlate the imaging appearance with the microscopic findings.
  • DESIGN AND PATIENTS: A retrospective review of five patients with a histopathologic diagnosis of GrCT and pre-operative MR imaging of the neoplasm was done.
  • A significant stromal component in the tumor and, hypothetically, a ribbon-like arrangement of tumor cells may influence the signal intensity demonstrated on the T1 and T2-weighted sequences.
  • The malignant subtype may demonstrate signal intensity characteristics and invasion of adjacent structures often seen with other aggressive neoplasms; sizes larger than 4 cm and association with major nerve trunks can be seen.
  • CONCLUSION: Benign GrCT has imaging characteristics which may distinguish this tumor from other soft tissue neoplasms, as well as the malignant type of this tumor.
  • [MeSH-major] Foot Diseases / pathology. Granular Cell Tumor / pathology. Hand / pathology. Shoulder / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology

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  • (PMID = 16003548.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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88. Ikeda K, Tate G, Suzuki T, Mitsuya T: Cytologic comparison of a primary parathyroid cancer and its metastatic lesions: a case report. Diagn Cytopathol; 2006 Jan;34(1):50-5
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  • The presence of prognostic factors Ki-67 and proliferating cell nuclear antigen (PCNA) was compared immunohistochemically between primary parathyroid carcinoma and related metastatic and recurrent foci.
  • Flow cytometric DNA analysis was also performed to investigate any chromosomal abnormality of the parathyroid carcinoma.
  • Cytologic examination of the endocrine tumor showed that it comprised a loose cohesive cluster and tumor cells with granular cytoplasm and mild nuclear atypia, but for purposes of cytodiagnosis, it is difficult to determine whether such a neoplasm is malignant on the basis of morphology alone.
  • Immunohistochemical analysis showed that Ki-67 and PCNA labeling indices were higher in the recurrent and metastasized carcinomas than in the primary cancer, suggesting that neoplastic cells become more malignant in the recurrent and metastasized foci.


89. Schrader KA, Nelson TN, De Luca A, Huntsman DG, McGillivray BC: Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11. Clin Genet; 2009 Feb;75(2):185-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple granular cell tumors are an associated feature of LEOPARD syndrome caused by mutation in PTPN11.
  • We report a patient with a clinical and molecular diagnosis of LEOPARD syndrome (LS) associated with multiple granular cell tumors (MGCT).
  • To our knowledge, this is the first report of MGCT associated with molecularly characterized LS and provides the first molecular evidence linking granular cell tumors (GCT) to the Ras/mitogen-activated protein (MAP) kinase pathway.
  • [MeSH-major] Granular Cell Tumor / genetics. LEOPARD Syndrome / genetics. Mutation, Missense. Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics


90. Pertile D, Scabini S, Romairone E, Scordamaglia R, Rimini E, Ferrando V: Gastric Abrikosoff tumor (granular cell tumor): case report. G Chir; 2010 Oct;31(10):433-4
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  • [Title] Gastric Abrikosoff tumor (granular cell tumor): case report.
  • Granular Cells Tumor (GCT), also called Abrikosoff tumor, is very uncommon lesion of neural derivation.
  • It is characterized by the presence of granular cell; benign and malignamt counterparts are known, even if the second ones are rare.
  • Surgical en-block excision is curative for both benign an malignant forms.
  • We report the case of a 45 year old man who had a cytologic diagnosis of fusocellular stromal tumor of the gastric fundus during examination for gastritis.
  • He underwent a wedge resection of the gastric wall: at the histological examination neoplastic cells had a granular cytoplasm and immunoassay was positive for S100 protein, PGP 9.5 and NSE.
  • [MeSH-major] Granular Cell Tumor. Stomach Neoplasms

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  • (PMID = 20939949.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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91. Pérez Valcárcel J, Sánchez Arca ME, Sousa Escandón A, Uribarri González CV: [Granular cell tumour of prostate diagnosed by transrectal biopsy. Which therapeutic attitude?]. Actas Urol Esp; 2006 Nov-Dec;30(10):1031-3
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  • [Title] [Granular cell tumour of prostate diagnosed by transrectal biopsy. Which therapeutic attitude?].
  • [Transliterated title] Tumor de células granulares de próstata diagnosticado en biopsia transrectal. Qué actitud tomar?
  • Granular cell tumour (GCT) is not an uncommon tumour of neural origin usually located on subcutaneous tissues and oral cavity.
  • The clinicpathological dilemma originated after this diagnosis is discused and the most suitable follow-up is proposed.
  • [MeSH-major] Granular Cell Tumor / pathology. Prostatic Neoplasms / pathology

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  • (PMID = 17253072.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 11
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92. Di Cicilia R, Castellucci P, Nannini M, Balbi T, Zannetti G, Fanti S, Biasco G, Pantaleo MA: Unusual finding of benign Abrikossoff tumor by F-18 FDG-PET mimicking melanoma recurrence. Clin Nucl Med; 2009 Oct;34(10):696-7
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  • [Title] Unusual finding of benign Abrikossoff tumor by F-18 FDG-PET mimicking melanoma recurrence.
  • Granular cell tumor of Abrikossoff is a rare neoplasm that may occur in a wide variety of cutaneous and visceral sites.
  • Granular cell tumor generally shows benign behavior.
  • However, malignant outcome with metastatic spread has also been reported.
  • Until now, no data were available on the most useful imaging approach for diagnosis and staging.
  • We present a case of F-18 fluorodeoxyglucose positron emission tomography in Abrikossoff tumor, suggesting that F-18 fluorodeoxyglucose positron emission tomography may have a potential role in the management of this neoplasm.
  • [MeSH-major] Fluorodeoxyglucose F18. Granular Cell Tumor / radionuclide imaging. Melanoma / radionuclide imaging. Positron-Emission Tomography
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Recurrence

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  • (PMID = 19893405.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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93. Pojchamarnwiputh S, Muttarak M, Na-Chiangmai W, Chaiwun B: Benign breast lesions mimicking carcinoma at mammography. Singapore Med J; 2007 Oct;48(10):958-68
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  • These lesions include abscess, haematoma, radial scar, post surgical scar, diabetic mastopathy, focal fibrosis, sclerosing adenosis, granular cell tumour, extra-abdominal desmoid tumour, medial insertion of pectoralis muscle and sternalis muscle, and axillary lymphadenopathy (due to HIV infection, collagen vascular lesions, tuberculous and bacterial lymphadenitis).
  • Radiologists should be familiar with the characteristic imaging features of these benign lesions, and should include these benign lesions in the differential diagnosis whenever malignant-appearing findings are encountered.
  • Correlation of the patient's clinical features with the mammographical findings and additional use of ultrasonography, fine-needle aspiration biopsy or core biopsy are helpful in establishing the final diagnosis and obviating unnecessary surgical intervention.
  • [MeSH-minor] Adult. Biopsy, Needle. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms / ultrasonography. Carcinoma / pathology. Carcinoma / radiography. Carcinoma / ultrasonography. Diagnosis, Differential. Female. Histocytochemistry. Humans. Middle Aged

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  • (PMID = 17909685.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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94. Marin VP, Yu P, Weber RS: Isolated cervical esophageal reconstruction for rare esophageal tumors. Head Neck; 2006 Sep;28(9):856-60
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  • [Title] Isolated cervical esophageal reconstruction for rare esophageal tumors.
  • We report 2 cases of rare esophageal tumors requiring reconstruction of the cervical esophagus after tumor resection.
  • METHODS AND RESULTS: The patients were a 51-year-old woman with an esophageal granular cell tumor and a 54-year-old woman with an esophageal schwannoma.
  • [MeSH-major] Cervicoplasty / methods. Esophageal Neoplasms / surgery. Granular Cell Tumor / surgery. Neurilemmoma / surgery. Surgical Flaps

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  • [Copyright] (c) 2006 Wiley Periodicals, Inc.
  • (PMID = 16835909.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Martelli-Júnior H, Mesquita RA, de Paula AM, Pêgo SP, Souza LN: Peripheral odontogenic fibroma (WHO type) of the newborn: a case report. Int J Paediatr Dent; 2006 Sep;16(5):376-9
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  • The differential diagnosis and treatment were discussed.
  • The clinical diagnosis of congenital granular cell tumour (congenital epulis) or dental lamina cyst of the newborn was made.
  • CONCLUSION: Despite the rarity of POF in a newborn, this lesion should be included as a possible diagnosis to focal gingival growth.

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  • (PMID = 16879337.001).
  • [ISSN] 0960-7439
  • [Journal-full-title] International journal of paediatric dentistry
  • [ISO-abbreviation] Int J Paediatr Dent
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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96. Saito K, Kato H, Fukai Y, Kimura H, Miyazaki T, Kashiwabara K, Nakajima T, Kuwano H: Esophageal granular cell tumor covered by intramucosal squamous cell carcinoma: report of a case. Surg Today; 2008;38(7):651-5
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  • [Title] Esophageal granular cell tumor covered by intramucosal squamous cell carcinoma: report of a case.
  • We report a case of a granular cell tumor (GCT) covered by squamous cell carcinoma (SCC) in the esophagus.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Esophageal Neoplasms / pathology. Granular Cell Tumor / pathology. Neoplasms, Multiple Primary / pathology

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  • [Cites] Ann Thorac Surg. 1996 Sep;62(3):860-5 [8784020.001]
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  • (PMID = 18612793.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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97. Núñez Hospital D, Sánchez Muñoz D, Schmidt Baumler A, Pinto Morales W, Ramírez Martín del Campo M, García Romero D, Pérez Pastor A, Guerrero Jiménez P, Grande Santamaría L, Miralles Sanchis EJ, Romero Gómez M: [Caecal granular cell tumours and Crohn's disease]. Gastroenterol Hepatol; 2007 May;30(5):315-6
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  • [Title] [Caecal granular cell tumours and Crohn's disease].
  • [Transliterated title] Tumor de células granulares cecal y enfermedad de Crohn.
  • [MeSH-major] Cecal Neoplasms / complications. Crohn Disease / complications. Granular Cell Tumor / complications
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Incidental Findings. Intestinal Perforation / etiology. Male. Middle Aged

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  • (PMID = 17493442.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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98. Tamborini F, Cherubino M, Scamoni S, Valdatta LA: Granular cell tumor of the toe: a case report. Dermatol Res Pract; 2010;2010
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  • [Title] Granular cell tumor of the toe: a case report.
  • Granular cell tumor is a rare tumor of unknown etiology that more commonly affects the oral cavity but can also occur at other sites.
  • The majorities of granular cell tumors are benign and present as a singular dermal nodule.
  • We discuss a case of granular cell tumor of the fourth toe in a 54-year-old patient that was treated with conservative surgery, instead of amputation, and reconstruction with a dermal regeneration template.

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  • (PMID = 20862204.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2938433
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99. Barbuţa OI, Aprodu GS, Gavrilescu S, Mihaila D, Iliev G, Olaru V, Munteanu V, Savu A: [Congenital oropharyngeal tumors in the newborn: problems in team diagnosis and treatment]. Rev Med Chir Soc Med Nat Iasi; 2006 Oct-Dec;110(4):883-6
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  • [Title] [Congenital oropharyngeal tumors in the newborn: problems in team diagnosis and treatment].
  • [Transliterated title] Tumori congenitale cu localizare orofaringiana la nou nascut: probleme de diagnostic şi tratament în echipa.
  • The differential diagnoses include tumors (malignant, teratoma, cystic hygroma, lymphangioma, hemangioma), congenital epulis, dermoid cysts, ranula.
  • Congenital epulis of the newborn is a rare tumour which is usually benign.
  • Epulis is also known as a congenital gingival granular cell tumour because of its histological features.
  • Epulis is located on the maxillary ridge twice as often as on the mandible, mostly as single tumours but rarely as multiple tumours.
  • The histogenesis of the tumour is unknown.
  • Recurrence of the tumour after surgery has not been reported yet.
  • In one case it was an antenatal diagnosis by ultrasonography, in the other it was associated a genital anomalies (hypospadias).
  • [MeSH-major] Gingival Neoplasms / diagnosis. Gingival Neoplasms / surgery. Granular Cell Tumor / diagnosis. Granular Cell Tumor / surgery
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Infant, Newborn. Male. Treatment Outcome

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  • (PMID = 17438893.001).
  • [ISSN] 0048-7848
  • [Journal-full-title] Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
  • [ISO-abbreviation] Rev Med Chir Soc Med Nat Iasi
  • [Language] rum
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Romania
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100. Novakov-Mikić A, Ivanović L, Lucić M, Kiralj A, Koprivsek K, Vucković N: [Prenatal diagnosis of granular cell myoblastoma--a case report]. Med Pregl; 2006 Nov-Dec;59(11-12):573-6
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  • [Title] [Prenatal diagnosis of granular cell myoblastoma--a case report].
  • INTRODUCTION: The aim of this paper is to present a case of prenatal diagnosis of a congenital tumor of the oral cavity diagnosed at 28 weeks of gestation.
  • CASE REPORT: After the diagnosis of oral cavity tumor was made by 21) ultrasound, a 3D scan was performed, which confirmed the diagnosis revealing a peduncle at the upper border of maxilla.
  • Magnetic resonance imaging was performed, confirming the diagnosis and the site of the tumor.
  • Regular three-week follow-up scans were performed to follow the growth of the tumor, as well as the state of the amniotic fluid.
  • No tumor growth was detected, and the amniotic fluid volume was normal until 39 weeks of gestation.
  • Cesarean section was scheduled, due to the risk of tumor disruption during a vaginal delivery.
  • The histopathological diagnosis was: granular cell myoblastoma.
  • The female newborn was developing normally, and at 5 months of age there were no traces of scarring at the place of the tumor.
  • CONCLUSION: In cases of prenatal diagnosis of tumors of the oral cavity, where development of polyhydramnios can be expected, as well as difficulties with feeding and breathing after birth, it is important to make a plan for adequate follow-up and prompt surgical treatment immediately after birth.
  • [MeSH-major] Granular Cell Tumor / congenital. Mouth Neoplasms / congenital. Mouth Neoplasms / diagnosis
  • [MeSH-minor] Female. Fetal Diseases / diagnosis. Humans. Infant, Newborn. Magnetic Resonance Imaging. Pregnancy. Ultrasonography, Prenatal

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  • (PMID = 17633900.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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