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Items 1 to 43 of about 43
1. Tsuda H, Ishikawa H, Asayama K, Saito T, Endo S, Mizutani T: Abducens nerve palsy and Horner syndrome due to metastatic tumor in the cavernous sinus. Intern Med; 2005 Jun;44(6):644-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abducens nerve palsy and Horner syndrome due to metastatic tumor in the cavernous sinus.
  • Two years later, right abducens nerve palsy and Horner syndrome appeared.
  • This is the first case of combination of abducens nerve palsy and ipsilateral Horner syndrome due to metastasis from parotid carcinoma to the cavernous sinus.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Carcinoma / secondary. Cavernous Sinus / pathology. Horner Syndrome / etiology. Neoplasms, Vascular Tissue / secondary. Parotid Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Diagnosis, Differential. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 16020898.001).
  • [ISSN] 0918-2918
  • [Journal-full-title] Internal medicine (Tokyo, Japan)
  • [ISO-abbreviation] Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Ayberk G, Ozveren MF, Yildirim T, Ercan K, Cay EK, Koçak A: Review of a series with abducens nerve palsy. Turk Neurosurg; 2008 Oct;18(4):366-73
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Review of a series with abducens nerve palsy.
  • OBJECTIVE: In this report, we aimed to investigate the patients that presented at our clinic complaint with diplopia due to the abducens nerve palsy and neurosurgical disease.
  • METHODS: The study design was a retrospective review of ten cases with the abducens nerve palsy.
  • The causes of the abducens nerve paralysis of our patients were as follows: two cases with head trauma, three cases with pituitary tumors, one case with sphenoid sinus mucocele, one case with greater superficial petrosal nerve cellular schwannoma at the petrous apex, one case with hypertensive intraventricular hemmorhage, one case with hydrocephalus, and one case with parotid tumor and skull base/brain stem invasion.
  • The lesions sited at the subarachnoid portion of the abducens nerve or in the cavernous sinus, the abducens nerve palsy improved or botilinum injection was performed during recovery period.
  • CONCLUSION: We presented abducens nerve palsy cases due to neruosurgical disorders.
  • A botilinum injection was performed in three patients with the abducens palsy.
  • Botilinum injection can help patients with sixth nerve palsy during the recovery period.
  • [MeSH-major] Abducens Nerve Diseases / pathology. Abducens Nerve Diseases / surgery
  • [MeSH-minor] Adolescent. Adult. Botulinum Toxins, Type A / therapeutic use. Brain Neoplasms / complications. Brain Neoplasms / pathology. Child. Craniocerebral Trauma / complications. Craniocerebral Trauma / pathology. Diplopia / etiology. Humans. Intracranial Pressure / physiology. Magnetic Resonance Imaging. Male. Middle Aged. Mucocele / complications. Mucocele / pathology. Neuromuscular Agents / therapeutic use. Paralysis / pathology. Paralysis / surgery. Retrospective Studies. Tomography, X-Ray Computed. Young Adult

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  • (PMID = 19107682.001).
  • [ISSN] 1019-5149
  • [Journal-full-title] Turkish neurosurgery
  • [ISO-abbreviation] Turk Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Neuromuscular Agents; EC 3.4.24.69 / Botulinum Toxins, Type A
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3. Ziyal IM, Bozkurt G, Bilginer B, Gülsen S, Ozcan OE: Abducens nerve palsy in a patient with a parasagittal meningioma--case report. Neurol Med Chir (Tokyo); 2006 Feb;46(2):98-100
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  • [Title] Abducens nerve palsy in a patient with a parasagittal meningioma--case report.
  • A 67-year-old female presented with isolated unilateral abducens nerve palsy progressing in 10 days.
  • The tumor was grossly totally removed and the patient's nerve palsy gradually improved within 3 weeks.
  • The mechanism of the isolated abducens nerve palsy in this case is attributed to compression of the abducens nerve by entrapment of the cerebrospinal fluid just before entering Dorello's canal under the petrolingual ligament.
  • Linear forces in the midsagittal plane due to the mass effect of the tumor may have temporarily increased the local cerebrospinal fluid pressure and caused 'pseudoentrapment' of the abducens nerve.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Abducens Nerve Diseases / physiopathology. Meningeal Neoplasms / complications. Meningeal Neoplasms / pathology. Meningioma / complications. Meningioma / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Staging. Treatment Outcome

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  • (PMID = 16498221.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Vachata P, Sames M: Abducens nerve schwannoma mimicking intrinsic brainstem tumor. Acta Neurochir (Wien); 2009 Oct;151(10):1281-7
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  • [Title] Abducens nerve schwannoma mimicking intrinsic brainstem tumor.
  • Schwannomas of the abducens nerve are extremely rare tumors affecting cavernous, cisternal or both segments of sixth cranial nerve.
  • Clinical features and neuroradiological imagery are frequently insufficient to reach an accurate pre-operative diagnosis.
  • We report a patient with a cystic tumor with ring-like contrast enhancement at the right anterior pontomesencephalic junction.
  • Radical excision was performed via anterior transpetrosal approach and showed an extrinsic tumor originating from the sixth nerve.
  • A postoperative sixth nerve palsy had disappeared completely 9 months after the surgery.
  • The correct diagnosis of an abducens nerve schwannoma is established by the intraoperative finding of a tumor attachment to the sixth nerve and by histopathological analysis.
  • The various differential diagnoses, the clinical and radiological features of this diagnosis and management are issues discussed in this illustrated review.
  • [MeSH-major] Abducens Nerve / pathology. Abducens Nerve Diseases / pathology. Brain Stem Neoplasms / diagnosis. Cranial Nerve Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Brain Stem / pathology. Brain Stem / radiography. Brain Stem / surgery. Craniotomy. Diagnosis, Differential. Diagnostic Errors / prevention & control. Facial Nerve Diseases / etiology. Hearing Loss / etiology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19357806.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 41
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5. Ishikawa E, Tsuboi K, Takano S, Kimura H, Aoki T, Mashiko R, Nagata M: Primary cerebral angiitis containing marked xanthoma cells with massive intraparenchymal involvement--case report--. Neurol Med Chir (Tokyo); 2005 Mar;45(3):156-60

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • A 27-year-old woman was referred to our hospital with mild disorientation, bilateral abducens nerve palsy, and mild left hemiparesis.
  • The diagnosis was primary cerebral angiitis containing marked xanthoma cells.
  • No neurological symptoms or recurrence of the tumor has been observed during the 6-year period since the operation.
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Abducens Nerve Diseases / pathology. Abducens Nerve Diseases / physiopathology. Adult. Confusion / etiology. Confusion / pathology. Confusion / physiopathology. Female. Histiocytes / pathology. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures. Paresis / etiology. Paresis / pathology. Paresis / physiopathology. Rare Diseases. Steroids / therapeutic use. Treatment Outcome

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  • (PMID = 15782008.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Steroids
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6. Kano T, Ikota H, Kobayashi S, Iwasa S, Kurosaki S, Wada H: Malignant transformation of an intracranial large epidermoid cyst with leptomeningeal carcinomatosis: case report. Neurol Med Chir (Tokyo); 2010;50(4):349-53
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  • A 64-year-old female presented with rapid onset of left ophthalmoplegia and truncal ataxia, after experiencing diplopia due to left abducens nerve palsy for a year.
  • The tumor was partially removed and the histological diagnosis was squamous cell carcinoma (SCC).
  • [MeSH-major] Brain Neoplasms / pathology. Carcinoma, Squamous Cell / pathology. Epidermal Cyst / pathology. Meningeal Carcinomatosis / pathology. Spinal Cord Neoplasms / secondary

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  • (PMID = 20448435.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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7. Abdul-Hussein A, Morris PA, Markova T: An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study. BMC Cancer; 2007;7:157
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual presentation of adenoid cystic carcinoma of the minor salivary glands with cranial nerve palsy: a case study.
  • BACKGROUND: Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region.
  • We report the first case of the 5th and 6th nerve palsy due to cavernous sinus invasion by adenoid cystic carcinoma.
  • There was numbness in all three divisions of the right trigeminal nerve.
  • Motor and sensory examination of extremities was normal.
  • Biopsy showed an ACC tumor with a cribriform pattern of the minor salivary glands.
  • The patient had long history of headaches which changed in character during the past year, and symptoms of acute 5th and 6th cranial nerve involvement.
  • Our unique case demonstrates direct invasion of cavernous sinus and could explain the 5th and 6th cranial nerve involvement as histopathology revealed no perineural invasion.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Carcinoma, Adenoid Cystic / complications. Salivary Gland Neoplasms / complications. Trigeminal Nerve Diseases / etiology

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  • (PMID = 17697321.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1994955
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8. Hirao M, Oku H, Sugasawa J, Utsumi T, Ikeda T: [Three cases of abducens nerve palsy accompanied by Horner syndrome]. Nippon Ganka Gakkai Zasshi; 2006 Jul;110(7):520-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Three cases of abducens nerve palsy accompanied by Horner syndrome].
  • PURPOSE: To report three cases of nasopharyngeal carcinoma, exhibiting abducens nerve palsy and Horner syndrome during the medical treatment of the tumor, whose invasive cavernous sinus lesions could be detected.
  • RESULTS: Right abducens nerve palsy, Horner syndrome, and impairment of the 1st division of the trigeminal nerve were recognized in all patients.
  • CONCLUSIONS: The abducens and sympathetic nerves run closely together in the cavernous sinus.
  • Nasopharyngeal carcinoma is apt to invade the cavernous sinus and often impairs the abducens nerve.
  • Therefore the presence of Horner syndrome and trigeminal palsy in combination with abducens nerve palsy should be cautiously investigated to confirm the existence of the cavernous sinus lesions.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Horner Syndrome / etiology. Nasopharyngeal Neoplasms / complications

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  • (PMID = 16884072.001).
  • [ISSN] 0029-0203
  • [Journal-full-title] Nippon Ganka Gakkai zasshi
  • [ISO-abbreviation] Nippon Ganka Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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9. Horinaka N, Ito Y, Miyajima M, Hishii M, Suzuki K, Saito M, Arai H: Intracranial peripheral primitive neuroectodermal tumor manifesting as abducens nerve palsy. Childs Nerv Syst; 2005 Apr;21(4):327-30
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  • [Title] Intracranial peripheral primitive neuroectodermal tumor manifesting as abducens nerve palsy.
  • INTRODUCTION: Peripheral primitive neuroectodermal tumor (PNET) occurring as an extra-axial lesion within the intracranial space and extending to the subarachnoid space is extremely rare.
  • CASE REPORT: An 18-month-old girl presented with an intracranial peripheral PNET manifesting as abducens nerve palsy.
  • Magnetic resonance imaging on admission revealed a lesion affecting the trigeminal and abducens nerves.
  • The tumor was partially removed via the subtemporal approach.
  • Histological examination showed a high-grade, undifferentiated neoplasm of small cell type with positive immunostaining for MIC2.
  • The histological diagnosis was peripheral PNET.
  • OUTCOME: Craniospinal radiotherapy reduced the tumor size, but adjuvant chemotherapy designed for Ewing's sarcomas and PNETs was not effective.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Brain Neoplasms / complications. Neuroectodermal Tumors, Primitive / complications
  • [MeSH-minor] Abducens Nerve / pathology. Female. Humans. Immunohistochemistry / methods. Infant. Magnetic Resonance Imaging / methods. Protozoan Proteins / metabolism

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  • (PMID = 15657787.001).
  • [ISSN] 0256-7040
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Protozoan Proteins; 120300-02-9 / thrombospondin-related adhesive protein, protozoan
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10. Park JH, Cho YH, Kim JH, Lee JK, Kim CJ: Abducens nerve schwannoma: case report and review of the literature. Neurosurg Rev; 2009 Jul;32(3):375-8; discussion 378
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  • [Title] Abducens nerve schwannoma: case report and review of the literature.
  • Schwannomas of the abducens nerve are extremely rare.
  • The authors report a case with this tumor and discuss its clinical and radiographic characteristics.
  • Right abducens nerve paresis was noted on neurologic examination.
  • Instead, the facial and vestibulocochlear nerve complex was found to be displaced posteriorly by the tumor on MR three-dimensional T2-weighted driven equilibrium sequence.
  • Resection of the tumor was carried out via retrosigmoid approach.
  • As the encapsulated partially suckable yellowish tumor was debulked and dissected, the abducens nerve was found to fan along and be attached to the medial surface of the tumor, which was cut at this point.
  • Complete excision of the tumor was accomplished, and reanimation of the nerve was done by end-to-end anastomosis.
  • Abducens schwannoma, although rare, should be taken into account for differential diagnosis of the cerebellopontine angle tumors.
  • Appreciation of the characteristic clinical and radiographic features may provide an accurate preoperative diagnosis.
  • [MeSH-major] Abducens Nerve Diseases / surgery. Neurilemmoma / surgery

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  • (PMID = 19418078.001).
  • [ISSN] 1437-2320
  • [Journal-full-title] Neurosurgical review
  • [ISO-abbreviation] Neurosurg Rev
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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11. Erlich SA, Tymianski M, Kiehl TR: Cellular schwannoma of the abducens nerve: case report and review of the literature. Clin Neurol Neurosurg; 2009 Jun;111(5):467-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cellular schwannoma of the abducens nerve: case report and review of the literature.
  • Schwannomas of the abducens nerve are extremely uncommon tumors.
  • Here, we report the case of a 26-year-old woman who presented with a 6th nerve palsy and was found to have a large tumor at the right side of her pons.
  • The case is presented in its clinical, neurosurgical and neuropathologic aspects and the literature on 6th nerve schwannomas is reviewed.
  • [MeSH-major] Abducens Nerve Diseases / pathology. Abducens Nerve Diseases / surgery. Cranial Nerve Neoplasms / pathology. Cranial Nerve Neoplasms / surgery. Neurilemmoma / pathology. Neurilemmoma / surgery
  • [MeSH-minor] Adult. Brain Stem Neoplasms / pathology. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Neurosurgical Procedures. Paralysis. Pons / pathology. Tomography, X-Ray Computed

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  • (PMID = 19200646.001).
  • [ISSN] 1872-6968
  • [Journal-full-title] Clinical neurology and neurosurgery
  • [ISO-abbreviation] Clin Neurol Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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12. Ayberk G, Ozveren MF, Uzum N, Tosun O, Akcay EK: Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. Neurosurgery; 2008 Oct;63(4):E813-4; discussion E814
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  • [Title] Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report.
  • OBJECTIVE: Cellular schwannomas (CS) are rare in the cranial space.
  • This report is the first of a patient with a greater superficial petrosal nerve CS presenting with abducens nerve palsy and xerophthalmia.
  • Neurological examination was normal except for the presence of right abducens nerve palsy.
  • It was thought that the schwannoma in our patient originated from the greater superficial petrosal nerve, based on the location of the tumor in addition to the absence of partial Horner's syndrome and a persistent decrease in tear secretion.
  • INTERVENTION: The tumor was exposed with the use of a right subtemporal extradural approach and removed entirely.
  • Pathological evaluation of the tumor revealed a CS.
  • CONCLUSION: The abducens nerve palsy improved completely in the follow-up period, but the decreased tear secretion did not resolve.
  • No adjuvant treatment was applied because of the tumor's benign character.
  • The greater superficial petrosal nerve schwannoma should be considered in the differential diagnosis of the abducens nerve palsy and petrous apex mass.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Facial Nerve / pathology. Facial Nerve Diseases / etiology. Neurilemmoma / complications. Neurilemmoma / surgery. Xerophthalmia / etiology

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  • (PMID = 18981849.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Tanioka D, Abe T, Kunii N, Izumiyama H: [A case of a hemorrhagic non-functioning pituitary adenoma presenting with abducens nerve palsy]. No Shinkei Geka; 2005 May;33(5):473-9
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  • [Title] [A case of a hemorrhagic non-functioning pituitary adenoma presenting with abducens nerve palsy].
  • A pituitary adenoma presenting with isolated abducens nerve palsy is an extremely rare occurrence.
  • The authors report a rare case of a hemorrhagic non-functioning pituitary adenoma presenting with isolated abducens nerve palsy.
  • The etiology of isolated abducens nerve palsy by a pituitary tumor is discussed.
  • On admission, he had right-sided isolated abducens nerve palsy.
  • The tumor was totally resected via the transnasal route.
  • The histological diagnosis was a typical non-functioning pituitary adenoma with hemorrhage.
  • The abducens nerve palsy was completely resolved 7 months after surgery.
  • It was supposed that the isolated abducens nerve palsy was caused by the direct compression of abducens nerve in the cavernous sinus by the extension of a pituitary tumor and hematoma.
  • Pituitary adenoma should be considered in the differential diagnosis of abducens nerve palsy.
  • Early diagnosis and transsphenoidal surgery is recommended to improve the abducens nerve palsy.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Adenoma / complications. Intracranial Hemorrhages / complications. Pituitary Neoplasms / complications

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  • (PMID = 15912767.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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14. Kau HC, Tsai CC: Abducens ocular neuromyotonia in a patient with nasopharyngeal carcinoma following concurrent chemoradiotherapy. J Neuroophthalmol; 2010 Sep;30(3):266-7
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  • [Title] Abducens ocular neuromyotonia in a patient with nasopharyngeal carcinoma following concurrent chemoradiotherapy.
  • We describe a case of ocular neuromyotonia (ONM) following concurrent chemoradiotherapy for nasopharyngeal carcinoma (NPC).
  • In the quiescent period, ocular motor examination revealed a partial left sixth nerve palsy.
  • While diplopic complaints in patients with NPC raise suspicion of tumor recurrence or radiation-related cranial neuropathy, ONM must also be kept in the differential diagnosis.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Drug-Related Side Effects and Adverse Reactions. Ocular Motility Disorders / etiology. Radiotherapy / adverse effects
  • [MeSH-minor] Antineoplastic Agents / adverse effects. Carcinoma / therapy. Cisplatin / adverse effects. Diplopia / etiology. Female. Fluorouracil / adverse effects. Humans. Immunosuppressive Agents / adverse effects. Middle Aged. Nasopharyngeal Neoplasms / therapy


15. Rodríguez JA, Hedges TR 3rd, Heilman CB, Strominger MB, Laver NM: Painful sixth cranial nerve palsy caused by a malignant trigeminal nerve sheath tumor. J Neuroophthalmol; 2007 Mar;27(1):29-31
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  • [Title] Painful sixth cranial nerve palsy caused by a malignant trigeminal nerve sheath tumor.
  • A 17-year-old woman developed a sixth cranial nerve palsy from a malignant peripheral nerve sheath tumor of the trigeminal nerve.
  • This case is unusual in that the principal symptom was diplopia stemming from a sixth cranial nerve palsy.
  • Treatment with gamma knife stereotactic radiosurgery produced some improvement in sixth cranial nerve function and reduction in tumor size over a follow-up period of 9 months.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Cranial Nerve Neoplasms / complications. Pain / etiology. Trigeminal Nerve Diseases / complications
  • [MeSH-minor] Adolescent. Biopsy. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Radiosurgery. Tomography, X-Ray Computed

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  • (PMID = 17414869.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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16. Leiba H, Wirth GM, Amstutz C, Landau K: Long-term results of vertical rectus muscle transposition and botulinum toxin for sixth nerve palsy. J AAPOS; 2010 Dec;14(6):498-501
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  • [Title] Long-term results of vertical rectus muscle transposition and botulinum toxin for sixth nerve palsy.
  • PURPOSE: To report the long-term outcome of full-tendon vertical rectus muscle transposition combined with chemodenervation of the ipsilateral medial rectus muscle for acquired chronic sixth (abducens) nerve palsy.
  • The etiologies for the palsy were head trauma (11), tumor (10), and idiopathic (1).
  • CONCLUSIONS: Vertical rectus muscle transposition combined with intraoperative botulinum toxin injection into the ipsilateral medial rectus muscle improved alignment in patients with complete chronic sixth nerve palsy.

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  • [Copyright] Copyright © 2010 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.
  • (PMID = 21094068.001).
  • [ISSN] 1528-3933
  • [Journal-full-title] Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
  • [ISO-abbreviation] J AAPOS
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Dyskinesia Agents; EC 3.4.24.69 / Botulinum Toxins
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17. Waldron JS, Tihan T, Parsa AT: Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma. Neurosurgery; 2006 Oct;59(4):E939-40; discussion E940
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  • [Title] Solitary fibrous tumor arising from Cranial Nerve VI in the prepontine cistern: case report and review of a tumor subpopulation mimicking schwannoma.
  • OBJECTIVE: The authors present a report of a solitary fibrous tumor (SFT) arising from the intradural component of the VIth cranial nerve as it travels through the prepontine cistern.
  • Because of their infrequency and clinical similarity to other central nervous system (CNS) lesions, diagnosis is largely dependent on pathological features.
  • In this study, the authors define a subpopulation of SFTs that seem to arise directly from nerve, rather than meninges, and clinically mimic the appearance of a schwannoma.
  • The patient was then taken to the operating room by a combined neurosurgical and ear, nose, and throat team, where the patient underwent a retrolabyrinthine/subtemporal craniotomy for tumor resection.
  • During resection of the prepontine component, the tumor was identified as originating from the left Cranial Nerve VI as it traversed through the prepontine cistern.
  • Resection of the tumor component involving the cavernous sinus and Meckel's cave was deferred for follow-up treatment with intensity-modulated radiation therapy.
  • Pathological examination revealed tissue consistent with the diagnosis of SFT.
  • This patient had an SFT masquerading as a VIth cranial nerve schwannoma.
  • Although the natural history of SFTs in the CNS is not completely understood, correct diagnosis is important, given the rate of recurrence found in the more common pleural-based SFT and examples of CNS SFTs with malignant features.
  • [MeSH-major] Abducens Nerve. Cranial Nerve Neoplasms / pathology. Fibroma / pathology. Neurilemmoma / pathology. Pons
  • [MeSH-minor] Adult. Cerebral Angiography. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Radiotherapy, Adjuvant

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  • (PMID = 17038929.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 26
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18. Dong Y, Wei SH, Pi YL, Yan RM: [Ocular manifestations of brainstem tumor]. Zhonghua Yan Ke Za Zhi; 2009 Nov;45(11):999-1003
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  • [Title] [Ocular manifestations of brainstem tumor].
  • OBJECTIVE: To investigate the ocular manifestations of brainstem tumors and to avoid misdiagnosis and missed diagnosis.
  • The clinical data of 57 brainstem tumor in-patients were collected from 1993 to 2007.
  • RESULTS: The present series included 51 cases of brainstem germinoma, 4 cases of cavernous hemangioma, 1 case of hemangioblastoma and 1 case of metastatic tumor.
  • Patients were presented with diplopia, ocular motility disturbance, nystagmus, anisocoria, and facial palsy.
  • The incidence of oculomotor nerve paralysis was 17.5% (10/57); trochlear paralysis, 1.8% (1/57); trigeminal nerve paralysis, 5.3% (3/57); abducens nerve paralysis, 35.1% (20/57); facial palsy, 14.0% (8/57); optic disc edema, 19.3% (11/57); nystagmus, 21.1% (12/57) and anisocoria, 10.5% (6/57).
  • CONCLUSIONS: Ocular manifestations occur frequently in brainstem tumor.
  • Nuclear ophthalmoplegia, nystagmus and other neuro-ophthalmic signs provide helpful clues for the diagnosis of brainstem tumor.
  • [MeSH-major] Brain Stem Neoplasms / pathology. Eye Diseases / pathology

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  • (PMID = 20137418.001).
  • [ISSN] 0412-4081
  • [Journal-full-title] [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
  • [ISO-abbreviation] Zhonghua Yan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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19. Hayashi M, Chernov M, Tamura N, Yomo S, Ochiai T, Nagai M, Tamura M, Izawa M, Muragaki Y, Iseki H, Okada Y, Takakura K: Gamma Knife surgery for abducent nerve schwannoma. Report of 4 cases. J Neurosurg; 2010 Dec;113 Suppl:136-43
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  • [Title] Gamma Knife surgery for abducent nerve schwannoma. Report of 4 cases.
  • Abducent nerve schwannomas are extremely rare.
  • The authors recently performed Gamma Knife surgery (GKS) in 4 patients with such tumors and describe their experiences with these cases.
  • Two patients had no symptoms, 1 complained of slight visual disturbances, and the other 1 had abducent nerve palsy.
  • All 4 tumors were located in the cavernous sinus: 2 of these tumors within the borders of the sinus, 1 tumor extending into the orbit, and 1 tumor extending into the prepontine cistern.
  • The volume of the neoplasms varied from 1.7 to 4.9 cm(3) (mean 3.0 cm(3)).
  • No patient underwent tumor resection.
  • The dose directed to the tumor margin was 12 Gy in all cases.
  • Imaging studies showed temporary enlargement of all tumors during the 1st posttreatment year, but thereafter, there was a trend toward reduction in volume.
  • None of the neoplasms displayed regrowth.
  • In the 3 patients who did not have abducent nerve palsy before GKS, it appeared, at least temporarily, after the procedure.
  • Purely intracavernous neoplasms in general followed uneventful posttreatment courses, but dumbbell-shaped tumors were associated with significant morbidity.
  • After GKS, the patient treated for an orbitocavernous schwannoma experienced a significant deterioration in vision, temporary blindness in 1 eye, and late development of permanent abducent nerve palsy, which were seemingly caused by compression of neurovascular structures within the anulus of Zinn during a temporary increase in the lesion's volume after irradiation.
  • Gamma Knife surgery controls the growth of abducent nerve schwannomas and may be effectively used to manage intracavernous neoplasms.
  • Caution, however, should be used in cases of dumbbell-shaped tumors, particularly those extending through the superior orbital fissure.
  • [MeSH-major] Abducens Nerve Diseases / surgery. Cavernous Sinus / surgery. Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery / instrumentation

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  • (PMID = 21121795.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Amemiya S, Aoki S, Ohtomo K: Cranial nerve assessment in cavernous sinus tumors with contrast-enhanced 3D fast-imaging employing steady-state acquisition MR imaging. Neuroradiology; 2009 Jul;51(7):467-70
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  • [Title] Cranial nerve assessment in cavernous sinus tumors with contrast-enhanced 3D fast-imaging employing steady-state acquisition MR imaging.
  • INTRODUCTION: The purpose of this study is to apply contrast-enhanced 3D fast-imaging employing steady-state acquisition (3D-FIESTA) imaging to the evaluation of cranial nerves (CN) in patients with cavernous sinus tumors.
  • METHODS: Contrast-enhanced 3D-FIESTA images were acquired from ten patients with cavernous sinus tumors with a 3-T unit.
  • RESULTS: In all cases, the trigeminal nerve with tumor involvement was easily identified in the cavernous portions.
  • Although oculomotor and abducens nerves were clearly visualized against the tumor area with intense contrast enhancement, they were hardly identifiable within the area lacking contrast enhancement.
  • The trochlear nerve was visualized in part, but not delineated as a linear structure outside of the lesion.
  • CONCLUSIONS: Contrast-enhanced 3D-FIESTA can be useful in the assessment of cranial nerves in and around the cavernous sinus with tumor involvement.
  • [MeSH-major] Brain Neoplasms / pathology. Cavernous Sinus / pathology. Cranial Nerves / pathology. Magnetic Resonance Angiography / methods
  • [MeSH-minor] Adult. Aged. Contrast Media. Female. Gadolinium. Hemangioma / pathology. Humans. Male. Meningioma / pathology. Middle Aged. Neoplasm Metastasis. Pituitary Neoplasms / pathology

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  • (PMID = 19238368.001).
  • [ISSN] 1432-1920
  • [Journal-full-title] Neuroradiology
  • [ISO-abbreviation] Neuroradiology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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21. Koop G, Gräf M: [Ocular neuromyotonia]. Klin Monbl Augenheilkd; 2006 Mar;223(3):247-51
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  • [Title] [Ocular neuromyotonia].
  • BACKGROUND: Ocular neuromyotonia is a rare ocular motility disorder characterized by involuntary contractions of one or several ocular motor muscles.
  • PATIENT AND METHODS: A 61-year-old female patient was referred with persistent diplopia despite previous surgical treatment for right 6 (th) nerve palsy.
  • The results coincide with data collected in our department from three other patients with ocular neuromyotonia (2 cranial nerve VI, 1 cranial nerve IV), over the past three years.
  • CONCLUSIONS: These typical findings permit the diagnosis of ocular neuromyotonia.
  • The characteristic symptoms of ocular neuromyotonia and the typical history of a previous intracranial tumor, treated neurosurgically with adjuvant radiotherapy, lead to the hypothesis that ephaptic transmission in the cranial nerve is the underlying pathophysiological mechanism in the development of ocular neuromyotonia.
  • [MeSH-major] Isaacs Syndrome / diagnosis. Ocular Motility Disorders / diagnosis
  • [MeSH-minor] Abducens Nerve Diseases / surgery. Carbamazepine / therapeutic use. Combined Modality Therapy. Diplopia / etiology. Female. Humans. Middle Aged. Postoperative Complications / diagnosis. Postoperative Complications / drug therapy. Strabismus / diagnosis. Strabismus / drug therapy

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  • (PMID = 16552659.001).
  • [ISSN] 0023-2165
  • [Journal-full-title] Klinische Monatsblätter für Augenheilkunde
  • [ISO-abbreviation] Klin Monbl Augenheilkd
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 33CM23913M / Carbamazepine
  • [Number-of-references] 36
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22. Müri RM, Klimmeck E, Imesch P: [Intermittent diplopia after prolonged downward gaze to the right: what is the differential diagnosis?]. Rev Neurol (Paris); 2005 May;161(5):575-7
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  • [Title] [Intermittent diplopia after prolonged downward gaze to the right: what is the differential diagnosis?].
  • In general, intermittent diplopia evokes suspicion of ocular myasthenia gravis.
  • We present a case of intermittent diplopia due to a tumor in the cavernous sinus.
  • In 1992, the diagnosis of inactive macroadenoma of the pituitary gland was established and the patient underwent surgery and radiation therapy.
  • At physical examination, prolonged downward gaze to the right of about 2 minutes provoked paresis of abduction, slight ptosis, and restriction of elevation on the left side, corresponding to sixth nerve palsy and palsy of the superior branch of the third nerve on the left side.
  • [MeSH-major] Adenoma / complications. Brain Neoplasms / complications. Cavernous Sinus. Diplopia / etiology
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Diagnosis, Differential. Fixation, Ocular / physiology. Humans. Male. Middle Aged. Neurologic Examination. Radiosurgery

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  • (PMID = 16106809.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. Pan L, Wang EM, Zhang N, Zhou LF, Wang BJ, Dong YF, Dai JZ, Cai PW: Long-term results of Leksell gamma knife surgery for trigeminal schwannomas. J Neurosurg; 2005 Jan;102 Suppl:220-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The mean target volume was 8.7 cm3 (range 0.8-33 cm3); the mean maximum dose was 27 Gy (range 20-40 Gy); the mean tumor margin dose was 13.3 Gy (range 10-15 Gy); and the mean follow-up period was 68 months (range 27-114 months).
  • Disappearance of the tumor occurred in seven patients.
  • An obvious decrease in tumor volume was observed in 41 patients, four tumors remained unchanged, and four tumors progressed at 5, 26, 30, and 60 months, respectively.
  • One patient with disease progression died of tumor progression at 36 months after GKS.
  • The tumor growth control rate in this group was 93% (52 of 56 cases).
  • Trigeminal nerve dysfunction was either unchanged or slightly worse in 13 patients after GKS.
  • Four patients experienced mild symptom deterioration related to tumor progression.
  • Some larger tumors are also suitable for radiosurgery if there is no significant brainstem compression.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery / instrumentation. Trigeminal Nerve / surgery
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Adolescent. Adult. Aged. Brain Diseases / etiology. Child. Cysts / etiology. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Radiation Dosage. Radiation Injuries / complications. Time

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  • (PMID = 15662814.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Fleseriu M, Lee M, Pineyro MM, Skugor M, Reddy SK, Siraj ES, Hamrahian AH: Giant invasive pituitary prolactinoma with falsely low serum prolactin: the significance of 'hook effect'. J Neurooncol; 2006 Aug;79(1):41-3
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  • The authors report a case of a patient with giant, invasive skull base tumor extending to the parasellar area discovered incidentally during the work-up for decreased memory.
  • Given the large size of the tumor, the elevated prolactin (PRL) was interpreted to be secondary to stalk effect and patient underwent debulking surgery through a transcranial approach.
  • Immunostaining of the excised tumor tissue was strongly positive for prolactin.
  • His prolactin was found to be 13,144 ng/ml in our lab after surgery confirming the diagnosis of invasive giant prolactinoma.
  • The patient developed a complete right third, fourth and sixth nerve palsy postoperatively.
  • He was started on Cabergoline with normalization of his prolactin level and more than 50% decrease in residual tumor size over 9 months periods.
  • [MeSH-major] Diagnostic Errors. Hyperprolactinemia / etiology. Pituitary Neoplasms / diagnosis. Prolactin / blood. Prolactinoma / diagnosis
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Diagnosis, Differential. Dopamine Agonists / therapeutic use. Ergolines / therapeutic use. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neurosurgical Procedures / adverse effects. Oculomotor Nerve Diseases / etiology. Skull Base Neoplasms / pathology. Trochlear Nerve Diseases / etiology

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  • (PMID = 16598425.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dopamine Agonists; 0 / Ergolines; 9002-62-4 / Prolactin; LL60K9J05T / cabergoline
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25. Koizumi H, Oka H, Utsuki S, Sato S, Tanizaki Y, Shimizu S, Suzuki S, Iizuka T, Sakai F, Fujii K: Primary germinoma arising from the midbrain. Acta Neurochir (Wien); 2006 Nov;148(11):1197-200; discussion 1200
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  • A 29-year-old man presented with diplopia, dysarthria, anisocoria, oculomotor nerve paralysis, abducens nerve paralysis, right facial palsy, and spastic hemiparetic gait.
  • MRI-guided stereotactic biopsy was performed, and the histologic diagnosis was pure germinoma.
  • The tumor disappeared after chemotherapy and radiotherapy.
  • Germinoma should be included in the differential diagnosis of midbrain lesions in young adults.
  • [MeSH-major] Brain Stem Neoplasms / diagnosis. Brain Stem Neoplasms / therapy. Germinoma / diagnosis. Germinoma / therapy. Mesencephalon / pathology
  • [MeSH-minor] Adult. Anisocoria / etiology. Anisocoria / pathology. Anisocoria / physiopathology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy. Diplopia / etiology. Diplopia / pathology. Diplopia / physiopathology. Drug Therapy. Humans. Magnetic Resonance Imaging. Male. Neuronavigation. Oculomotor Nerve Diseases / etiology. Oculomotor Nerve Diseases / pathology. Oculomotor Nerve Diseases / physiopathology. Radiotherapy. Treatment Outcome

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  • (PMID = 17039305.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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26. Yamaguchi S, Terasaka S, Ando S, Shinohara T, Iwasaki Y: Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report. Surg Neurol; 2008 Oct;70(4):403-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CASE DESCRIPTION: We report a 65-year-old woman who presented with a large clival plasmacytoma causing right trigeminal and abducens nerve palsies and was diagnosed with MM after transsphenoidal biopsy.
  • She underwent neoadjuvant chemoradiotherapy followed by radical resection of the residual tumor.
  • [MeSH-minor] Aged. Combined Modality Therapy. Cranial Fossa, Posterior / pathology. Dexamethasone / therapeutic use. Doxorubicin / therapeutic use. Female. Humans. Magnetic Resonance Imaging. Neurosurgical Procedures. Salvage Therapy. Vincristine / therapeutic use

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  • (PMID = 18291467.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; VAD I protocol
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27. Kato K, Wanifuchi H, Watanabe A: [Cyst formation after gamma knife radiosurgery for trigeminal schwannoma: a case report]. No Shinkei Geka; 2009 Jun;37(6):573-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • An 81-year-old male presented with abducens palsy and ataxia 6 years after gamma knife radiosurgery for trigeminal schwannoma.
  • The cyst was removed and the abducens palsy and ataxia improved within a month.
  • Histological findings revealed variable tumor tissue in the cyst wall.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Cysts / etiology. Neurilemmoma / surgery. Radiosurgery / adverse effects. Trigeminal Nerve Diseases / surgery

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  • (PMID = 19522285.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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28. Grau S, Schueller U, Weiss C, Tonn JC: Primary meningeal T-cell lymphoma at the clivus mimicking a meningioma. World Neurosurg; 2010 Oct-Nov;74(4-5):513-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Most primary lymphomas of the central nervous system (CNS) are of B-cell origin and are found intra-axially, with a few reported cases of skull base tumors involving the upper clivus or sellar region or both.
  • In this case, a tumor resembling a clivus meningioma without osseous involvement was surgically removed and turned out to be a primary T-cell lymphoma.
  • CASE REPORT: A 60-year-old woman presented with slight right-sided abducens nerve palsy.
  • Cranial imaging revealed an extra-axial mass at the caudal clivus resembling a meningioma.
  • The tumor was removed surgically; smear preparations obtained intraoperatively were inconclusive presumably because of preoperative steroid treatment.
  • The final diagnosis was peripheral T-cell lymphoma, not otherwise unspecified.
  • CONCLUSIONS: Although a very rare entity among primary T-cell lymphomas of the CNS, these tumors also can occur as skull base lesions without involvement of the bone.
  • Preoperative steroid medication may complicate intraoperative histologic assessment and lead to inadequate treatment of these tumors.
  • [MeSH-major] Cranial Fossa, Posterior / surgery. Infratentorial Neoplasms / diagnosis. Lymphoma, T-Cell / diagnosis. Meningeal Neoplasms / diagnosis. Meningioma / diagnosis. Skull Base Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21492604.001).
  • [ISSN] 1878-8769
  • [Journal-full-title] World neurosurgery
  • [ISO-abbreviation] World Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Yamada S, Fukuhara N, Oyama K, Takeshita A, Takeuchi Y: Repeat transsphenoidal surgery for the treatment of remaining or recurring pituitary tumors in acromegaly. Neurosurgery; 2010 Oct;67(4):949-56
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Repeat transsphenoidal surgery for the treatment of remaining or recurring pituitary tumors in acromegaly.
  • BACKGROUND: Acromegaly is a disorder characterized by hypersecretion of growth hormone caused by a growth hormone-secreting pituitary adenoma.
  • Only 1 patient was undergoing additional hormonal replacement after surgery, although transient cerebrospinal fluid leak, transient abducens nerve palsy, severe nasal bleeding, and pituitary abscess occurred in each patient, respectively.
  • Multivariate analysis clarified that a favorable surgical outcome was achieved in patients without cavernous sinus invasion (hazard ratio 12.56), tumor segmentation (hazard ratio 5.82), or in those older than 40 years old (hazard ratio 3.21).
  • [MeSH-major] Acromegaly / etiology. Acromegaly / surgery. Growth Hormone / secretion. Hypophysectomy / adverse effects. Pituitary Neoplasms / complications

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  • (PMID = 20881560.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9002-72-6 / Growth Hormone
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30. Cherekaev VA, Shchekut'ev GA, Ogurtsova AA, Gol'binh DA, Smirnov RA: [Intraoperative identification of oculomotor, trochlear and abducent nerves in surgery of invasive cranioorbital tumors (new technique)]. Zh Vopr Neirokhir Im N N Burdenko; 2010 Jul-Sep;(3):31-6; discussion 36-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intraoperative identification of oculomotor, trochlear and abducent nerves in surgery of invasive cranioorbital tumors (new technique)].
  • BACKGROUND: Aim of the study was to evaluate effectiveness of intraoperative identification of oculomotor nerves (OMN) in resection of skull base tumors invading superior orbital fissure and cavernous sinus.
  • MATERIALS AND METHODS: 69 patients with cranioorbital tumors operated in Burdenko Neurosurgical Institute (Moscow, Russia) since 2000 until 2005 were included in the study.
  • Intraoperative identification of OMN was performed using coaxial electrode while muscular response was registered through electrodes inserted in m. levator palpebrae superioris, m. obliquus superior and m. rectus lateralis (for III, IV and VI cranial nerves, respectively).
  • Identification of IMN trunci was repeated throughout the whole stage of tumor resection for their preservation.
  • The rates in main and control groups were: for III and IV nerves--37% and 68% (p < 0.05), for VI nerve--47% and 54% (p > 0.05), respectively.
  • CONCLUSION: application of intraoperative identification of OMN allows to decrease the risk of oculomotor deterioration due to III and IV nerve dysfunction by 1.8 times.
  • [MeSH-major] Abducens Nerve. Eye Movement Measurements / instrumentation. Eye Movements. Meningioma. Orbital Neoplasms. Trochlear Nerve
  • [MeSH-minor] Adult. Aged. Electrodes. Female. Humans. Intraoperative Care / instrumentation. Intraoperative Care / methods. Male. Middle Aged. Neoplasm Invasiveness. Ocular Motility Disorders / pathology. Ocular Motility Disorders / physiopathology. Ocular Motility Disorders / surgery

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  • (PMID = 21254574.001).
  • [ISSN] 0042-8817
  • [Journal-full-title] Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko
  • [ISO-abbreviation] Zh Vopr Neirokhir Im N N Burdenko
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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31. Inui T, Morimoto T, Koshimae N, Nagata K, Aketa S, Hironaka Y, Tei R: Dura-based giant intracranial schwannoma in the middle fossa. Neurol Med Chir (Tokyo); 2007 Aug;47(8):367-70
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  • Surgery via the transsylvian approach confirmed the origin of the tumor between the left internal carotid artery and the trigeminal nerve in the lateral wall of the cavernous sinus.
  • Elongated abducens nerve was confirmed, but no tumor adhesion to the abducens nerve was found.
  • The tumor was closely attached to the dura mater of the middle fossa and the lateral wall of the cavernous sinus.
  • The histological diagnosis was schwannoma.
  • Both left oculomotor and abducens nerve pareses occurred immediately after the operation but gradually resolved over 3 months.
  • The operative findings indicated that this schwannoma may have arisen from the meningeal branch of the trigeminal nerve in the dura mater of the middle fossa.
  • [MeSH-major] Cavernous Sinus / pathology. Cranial Fossa, Middle / pathology. Cranial Nerve Neoplasms / pathology. Dura Mater / pathology. Meningeal Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Medical Illustration. Middle Aged. Neurosurgical Procedures. Postoperative Complications. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve Diseases / pathology. Trigeminal Nerve Diseases / physiopathology. Trigeminal Nerve Diseases / surgery

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  • (PMID = 17721054.001).
  • [ISSN] 0470-8105
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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32. Li MH, Hong T, Li YY, Zhou DW, Zeng EM, Xu GS: [Surgical management of petroclival meningiomas invading into cavernous sinus]. Zhonghua Yi Xue Za Zhi; 2010 Feb 2;90(5):295-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The presigmoidal approach was selected to remove tumors.
  • The surgical strategy for tumor in cavernous sinus was partial resection combined with radiosurgery.
  • Postoperative cranial nerve function and patient survival status were analyzed.
  • RESULTS: The main symptoms of subtype of petroclival meningiomas were headache, abducens nerve palsy and trigeminal neuropathy.
  • Gross total tumor removal was achieved in 13 cases and more than 90% resection in 2 cases.
  • Nine cases suffered from new postoperative cranial nerve deficits.
  • After a follow-up of 6 - 59 months, complete improvement was achieved in oculomotor nerve deficits, much improvement in VII nerve deficit, but V and VI nerve function deficits improved slightly.
  • The tumor progression-free survival rate was 86.7%.
  • [MeSH-major] Cavernous Sinus / pathology. Meningioma / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 20368047.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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33. Mathiesen T, Gerlich A, Kihlström L, Svensson M, Bagger-Sjöbäck D: Effects of using combined transpetrosal surgical approaches to treat petroclival meningiomas. Neurosurgery; 2007 Jun;60(6):982-91; discussion 991-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We analyzed our series of transpetrosally operated petroclival meningiomas to obtain detailed information regarding the surgery outcomes with respect to facial nerve effects, hearing changes, general neurological and psychosocial differences, and recurrence rates to identify opportunities for improvement.
  • Facial nerve function was found to be of House-Brackmann Grade 3 or worse in six patients (including three individuals with transcochlear surgery and facial nerve rerouting).
  • Outcomes can be improved, however by improving patients' psychosocial support; striving to decompress, preserve, and minimize dissection of ill-defined planes of cranial nerves; and using Simpson Grade 4 gamma knife approaches when radicality is precluded.
  • Currently, the performance of transpetrosal surgery for petroclival meningiomas is a major undertaking that significantly affects a patient's health for several years; however, the approaches that we used allowed a high degree of tumor control with relatively little neurological morbidity.
  • [MeSH-major] Meningioma / surgery. Neurosurgical Procedures / methods. Skull Base Neoplasms / surgery
  • [MeSH-minor] Abducens Nerve / physiopathology. Adolescent. Adult. Aged. Cranial Sinuses. Facial Nerve / physiopathology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Recovery of Function. Retrospective Studies. Treatment Outcome

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  • [ReprintIn] Neurosurgery. 2008 Jun;62(6 Suppl 3):1213-23 [18695542.001]
  • (PMID = 17538371.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Seiz M, Radek M, Buslei R, Kreutzer J, Hofmann B, Kottler U, Doerfler A, Nimsky C, Fahlbusch R: Alveolar rhabdomyosarcoma of the clivus with intrasellar expansion: Case report. Zentralbl Neurochir; 2006 Nov;67(4):219-22
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  • Rhabdomyosarcomas are common tumors of the head and neck region in children.
  • However, a primarily intracranial localization of this tumor entity is rare.
  • We report on a 3-year-old boy presenting with double vision due to left VI (th) nerve palsy.
  • Transsphenoidal biopsy was performed and histopathological examination as well as molecular diagnostics confirmed the diagnosis of an alveolar rhabdomyosarcoma (ARMS).
  • Staging identified a metastatic lesion in the fourth thoracic vertebra resulting in the diagnosis of stage IV disease.
  • [MeSH-major] Pituitary Neoplasms / surgery. Rhabdomyosarcoma / surgery
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Abducens Nerve Diseases / pathology. Adrenocorticotropic Hormone / deficiency. Angiography. Antineoplastic Agents / administration & dosage. Antineoplastic Agents, Phytogenic / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Brain / pathology. Carboplatin / administration & dosage. Child, Preschool. Etoposide / administration & dosage. Human Growth Hormone / deficiency. Humans. Magnetic Resonance Imaging. Male. Radiosurgery. Sella Turcica / pathology. Sella Turcica / surgery. Spine / pathology

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  • (PMID = 17139605.001).
  • [ISSN] 0044-4251
  • [Journal-full-title] Zentralblatt für Neurochirurgie
  • [ISO-abbreviation] Zentralbl. Neurochir.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 12629-01-5 / Human Growth Hormone; 6PLQ3CP4P3 / Etoposide; 9002-60-2 / Adrenocorticotropic Hormone; BG3F62OND5 / Carboplatin
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35. Bohner G, Masuhr F, Distl R, Katchanov J, Klingebiel R, Zschenderlein R, von Deimling A, van Landeghem FK: Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. Acta Neuropathol; 2005 Sep;110(3):306-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a 25-year-old male patient with primary diffuse leptomeningeal gliomatosis (PDLG) presenting with gait ataxia, positive Lhermitte's sign, double vision, and right abducens nerve palsy.
  • A thorough autopsy showed no evidence for primary neoplasms in brain, spine and optic nerve.
  • Sequence analysis of tumor protein 53 gene (TP53) revealed a missense mutation in exon 5, and expression of phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN) protein was not detected, which may have contributed to astrocytoma development.
  • [MeSH-major] Astrocytoma / pathology. Meningeal Neoplasms / pathology. Meninges / pathology. Neoplasms, Neuroepithelial / pathology. Neoplasms, Unknown Primary / pathology. Subarachnoid Space / pathology
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / genetics. Brain / pathology. Brain / physiopathology. Diagnosis, Differential. Fatal Outcome. Humans. Magnetic Resonance Imaging. Male. Mutation / genetics. Spinal Cord / pathology. Spinal Cord / physiopathology. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Spinal Cord Compression / physiopathology. Tumor Suppressor Protein p53 / genetics

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  • (PMID = 16003541.001).
  • [ISSN] 0001-6322
  • [Journal-full-title] Acta neuropathologica
  • [ISO-abbreviation] Acta Neuropathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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36. Shah GB, Bhaduri AS, Misra BK: Ectopic craniopharyngioma of the fourth ventricle: case report. Surg Neurol; 2007 Jul;68(1):96-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The patient underwent midline posterior fossa craniotomy and tumor excision, with prompt relief of gaze palsy.
  • We found no evidence to correlate this tumor to the suprasellar region.
  • CONCLUSION: Craniopharyngioma may not always be in primary communication with suprasellar tumor.
  • [MeSH-major] Cerebral Ventricle Neoplasms / diagnosis. Craniopharyngioma / diagnosis. Fourth Ventricle / pathology. Magnetic Resonance Imaging
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Child. Female. Humans. Hydrocephalus / etiology. Intracranial Pressure. Neurosurgical Procedures

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  • (PMID = 17586238.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Muto J, Kawase T, Yoshida K: Meckel's cave tumors: relation to the meninges and minimally invasive approaches for surgery: anatomic and clinical studies. Neurosurgery; 2010 Sep;67(3 Suppl Operative):ons291-8; discussion ons298-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Meckel's cave tumors: relation to the meninges and minimally invasive approaches for surgery: anatomic and clinical studies.
  • BACKGROUND: Literature on tumors originating from Meckel's cave (MC) and their surgical treatment are scarce.
  • OBJECTIVE: We present 37 cases of tumors originating from MC, the largest single-institution series reported thus far, and discuss the ideal surgical methods for each tumor type in relation to the normal and pathological anatomy of MC.
  • METHODS: We studied 37 cases of surgery for tumors in MC (26 schwannomas, 7 meningiomas, 2 epidermoids, 1 hemangiopericytoma, and 1 dermoid) performed at our institution between 1986 and 2008.
  • We excluded cases of large tumors of unknown origin, especially meningiomas.
  • Surgery for tumors in MC was performed via 2 approaches: anterolateral interdural access (Dolenc's) approach and posterior access via the anterior petrosal approach (APA).
  • RESULTS: The Dolenc approach was useful for parasellar tumors, especially schwannomas, because it resulted in minimal damage to the temporal lobe and adjacent cranial nerves.
  • The APA was useful for dumbbell-shaped tumors extending into the posterior fossa.
  • Tumors of nonmeningeal origin (schwannomas, epidermoids, and dermoids) were safely resected, with no postoperative complications except facial hypesthesia.
  • However, incidence of postsurgical paresthesia and abducens palsy were higher in meningioma and hemangiopericytoma, because of invasion into the Gasserian ganglion, the cavernous sinus (CS), or Dorello's canal.
  • CONCLUSION: An understanding of meningeal structure around MC enhances the radicality of tumor resection and helps minimize damage to adjacent structures.
  • [MeSH-major] Meningeal Neoplasms / surgery. Meningioma / surgery. Neurilemmoma / surgery. Neurosurgical Procedures / methods. Skull Base Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Trigeminal Nerve / pathology. Trigeminal Nerve / surgery. Young Adult

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  • (PMID = 20679921.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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38. Ohshima T, Ogura K, Nakayashiki N, Tachibana E: Intravascular papillary endothelial hyperplasia at the superior orbital fissure: report of a case successfully treated with gamma knife radiosurgery. Surg Neurol; 2005 Sep;64(3):266-9; discussion 269
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  • CASE DESCRIPTION: A 41-year-old woman presented with progressive left abducens nerve paresis and left facial sensory disturbance over a 1-year period.
  • Radiological examination demonstrated a left middle fossa tumor involved in the cavernous sinus.
  • About a half removal of the tumor was performed.
  • The pathological diagnosis was IPEH.
  • The residual tumor was treated with gamma knife radiosurgery.
  • CONCLUSION: Gamma knife radiosurgery was effective to reduce the residual tumor in the present case.

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  • (PMID = 16099263.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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39. Endo H, Fujimura M, Kumabe T, Kanamori M, Watanabe M, Tominaga T: Application of high-definition flexible neuroendoscopic system to the treatment of primary pineal malignant B-cell lymphoma. Surg Neurol; 2009 Mar;71(3):344-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Endoscopic procedure for pineal region tumors and associated hydrocephalus has been getting more standard.
  • Efficacy of this new technology as an initial treatment of pineal region tumors is discussed.
  • CASE DESCRIPTION: A 31-year-old man presented with progressive left abducens nerve palsy with headache and nausea.
  • Magnetic resonance imaging showed multiple enhanced lesions in several cranial nerves and obstructive hydrocephalus due to a pineal cystic lesion with nodular enhancement on its roof.
  • Diagnostic endoscopic biopsy of the pineal region tumor and ETV were performed using new flexible endoscopic system, in which a small CCD camera is implanted at the tip of the flexible scope, without complications.
  • Histopathologic diagnosis of the pineal region tumor was malignant B-cell lymphoma.
  • CONCLUSION: Endoscopic biopsy and ETV for pineal region tumors can be safely achieved using a high-definition flexible neuroendoscopic system.
  • Moreover, this system allowed us to observe disseminated lesions that are not revealed by preoperative neuroradiologic studies, which might enable us to make staging diagnosis of the disease.

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  • (PMID = 18207502.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Esposito F, Kelly DF, Vinters HV, DeSalles AA, Sercarz J, Gorgulhos AA: Primary sphenoid sinus neoplasms: a report of four cases with common clinical presentation treated with transsphenoidal surgery and adjuvant therapies. J Neurooncol; 2006 Feb;76(3):299-306
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary sphenoid sinus neoplasms: a report of four cases with common clinical presentation treated with transsphenoidal surgery and adjuvant therapies.
  • BACKGROUND: Primary neoplasms of the sphenoid sinus are a rare occurrence, accounting for approximately 1-2% of all paranasal sinus tumors.
  • METHODS: Four patients with sphenoid sinus neoplasms were identified (1%), all treated during the year 2003.
  • Two patients presented with unilateral abducens cranial nerve (CN) palsies; one had trigeminal facial numbness and dizziness; another had headache, epistaxis, and partial third and fourth CN palsies.
  • Cavernous sinus invasion was present in all four cases, including one patient with tumor in the ethmoid sinus and intra-tumoral hemorrhage.
  • All patients underwent subtotal tumor removal via an endonasal transsphenoidal route.
  • Tumor histology included neuroendocrine carcinoma, sinonasal undifferentiated carcinoma, mucoepidermoid carcinoma, and giant cell tumor.
  • One patient required a second endonasal tumor debulking 15 months after the first for new visual loss that then resolved.
  • CONCLUSIONS: Intra-sphenoidal tumors are locally invasive tumors that include a wide pathological spectrum.
  • Recognizing their distinctive clinical presentation and MRI features is helpful in differentiating them from primary sellar tumors.
  • [MeSH-major] Neurosurgical Procedures. Paranasal Sinus Neoplasms / pathology. Paranasal Sinus Neoplasms / therapy. Sphenoid Sinus / pathology

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  • (PMID = 16163447.001).
  • [ISSN] 0167-594X
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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41. Kramer CK, Ferreira N, Silveiro SP, Gross JL, Dora JM, Azevedo MJ: Pituitary gland metastasis from renal cell carcinoma presented as a non-functioning macroadenoma. Arq Bras Endocrinol Metabol; 2010;54(5):498-501
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  • Metastatic tumors involving the pituitary gland are an uncommon finding and occur in up to 1% of all pituitary tumor resections.
  • On ophthalmologic examination, there was a left abducens nerve palsy and bitemporal hemianopia.
  • The patient underwent a transsphenoidal tumor resection that revealed renal cell carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Pituitary Neoplasms / secondary
  • [MeSH-minor] Adenoma / diagnosis. Aged. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 20694412.001).
  • [ISSN] 1677-9487
  • [Journal-full-title] Arquivos brasileiros de endocrinologia e metabologia
  • [ISO-abbreviation] Arq Bras Endocrinol Metabol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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42. Pérez Marín JC, Apolinario Hidalgo RM, Mohamad Tubío AM, Santos Moyano Z, Peña Quintana P, Gómez Díaz J: [A 25-year-old man with pancreatic tumor, double vision and bone lesions]. Gastroenterol Hepatol; 2008 Nov;31(9):626-8
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  • [Title] [A 25-year-old man with pancreatic tumor, double vision and bone lesions].
  • [Transliterated title] Varón de 25 años de edad con un tumor pancreático, diplopía y lesiones óseas.
  • [MeSH-major] Bone Neoplasms / secondary. Diplopia / etiology. Pancreatic Neoplasms / complications. Sarcoma, Ewing / secondary
  • [MeSH-minor] Abducens Nerve Diseases / etiology. Adult. Humans. Magnetic Resonance Imaging. Male. Osteolysis / etiology. Osteolysis / radiography. Skull Neoplasms / complications. Skull Neoplasms / radiography. Skull Neoplasms / secondary. Spinal Neoplasms / complications. Spinal Neoplasms / radiography. Spinal Neoplasms / secondary. Tomography, X-Ray Computed

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  • (PMID = 19091260.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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43. Yoong HS, Kiaang TK: Gradenigo's syndrome presenting as a tumor. Otolaryngol Head Neck Surg; 2006 Nov;135(5):821-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gradenigo's syndrome presenting as a tumor.
  • [MeSH-major] Abducens Nerve. Brain Neoplasms / diagnosis. Diplopia / complications. Otitis Media / diagnosis
  • [MeSH-minor] Child. Diagnosis, Differential. Headache / complications. Humans. Male. Syndrome

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  • (PMID = 17071324.001).
  • [ISSN] 0194-5998
  • [Journal-full-title] Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • [ISO-abbreviation] Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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