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1. Jung SH, Paik CN, Jung JH, Lee KM, Chung WC, Yang JM: Simultaneous Colonic Obstruction and Hydroureteronephrosis due to Mesenteric Fibromatosis. Gut Liver; 2009 Sep;3(3):215-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous Colonic Obstruction and Hydroureteronephrosis due to Mesenteric Fibromatosis.
  • Mesenteric fibromatosis (MF) is a rare benign mesenchymal lesion that can occur throughout the gastrointestinal tract, especially small bowel.
  • We described a patient that presented with colonic obstruction and hydroureteronephrosis due to MF at sigmoid colon which mimicked submucosal tumor such as gastrointestinal tumor.
  • This case resulted in a positive positron emission tomography scan suggesting malignant neoplasm, but beta-catenin positivity on immunohistochemical staining separated MF from gastrointestinal stromal tumor and sclerosing mesenteritis.

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  • (PMID = 20431749.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852704
  • [Keywords] NOTNLM ; Colonic obstruction / Hydroureteronephrosis / Mesenteric fibromatosis
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2. Hatzimarkou A, Filippou D, Papadopoulos V, Filippou G, Rizos S, Skandalakis P: Desmoid tumor in Gardner's Syndrome presented as acute abdomen. World J Surg Oncol; 2006;4:18
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  • [Title] Desmoid tumor in Gardner's Syndrome presented as acute abdomen.
  • BACKGROUND: Gardner's syndrome can occasionally be complicated with intra-abdominal desmoid tumor.
  • CASE PRESENTATION: A rare case of a 41-year-old male patient with Gardner's syndrome complicated with intra-abdominal desmoid tumor, which first presented as acute abdomen, is presented.
  • CONCLUSION: Extra-abdominal manifestations of Gardner's syndrome along with a palpable abdominal mass would raise suspicion for the presence of a desmoid tumor in the majority of cases.

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  • (PMID = 16569244.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1479346
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3. Rajesh A, Sandrasegaran K: Mesenteric desmoid mimicking recurrent testicular cancer. Abdom Imaging; 2005 Nov-Dec;30(6):777-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric desmoid mimicking recurrent testicular cancer.
  • The detection of a solid abdominal mass after surgery for testicular cancer most frequently represents metastatic disease.
  • We report an unusual case of mesenteric desmoid tumor presenting after retroperitoneal lymph node dissection for metastatic testicular cancer.
  • [MeSH-major] Fibromatosis, Aggressive / radiography. Mesentery. Neoplasm Recurrence, Local / radiography. Peritoneal Neoplasms / radiography. Testicular Neoplasms / radiography

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  • (PMID = 16096867.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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4. Komatsu S, Ichikawa D, Kurioka H, Koide K, Ueshima Y, Shioaki Y, Lee CJ, Mutoh F, Hosokawa Y, Oka T, Yamagishi H: Intra-abdominal desmoid tumor mimicking lymph node recurrence after gastrectomy for gastric cancer. J Gastroenterol Hepatol; 2006 Jul;21(7):1224-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intra-abdominal desmoid tumor mimicking lymph node recurrence after gastrectomy for gastric cancer.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adenocarcinoma / surgery. Fibromatosis, Aggressive / diagnosis. Gastrectomy. Neoplasm Recurrence, Local / diagnosis. Stomach Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16824087.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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5. Lahat G, Nachmany I, Itzkowitz E, Abu-Abeid S, Barazovsky E, Merimsky O, Klauzner J: Surgery for sporadic abdominal desmoid tumor: is low/no recurrence an achievable goal? Isr Med Assoc J; 2009 Jul;11(7):398-402
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  • [Title] Surgery for sporadic abdominal desmoid tumor: is low/no recurrence an achievable goal?
  • BACKGROUND: Sporadic abdominal desmoid tumors are rare and data on these tumors as a distinct disease entity are lacking.
  • Previous abdominal surgery, trauma, pregnancy and estrogen intake are considered risk factors.
  • OBJECTIVES: To evaluate outcomes of surgery for this rare disease.
  • METHODS: Since 1995, 16 patients with pathologically confirmed desmoid tumor were operated on in our center.
  • All patients presented with an isolated mass; 7 (50%) originated in the abdominal wall, 6 (37.5%) were retroperitoneal and 3 were (18.8%) mesenteric.
  • CONCLUSIONS: The perception of sporadic abdominal desmoids as tumors with a high recurrence rate (20-70%) is probably incorrect.
  • [MeSH-major] Abdominal Neoplasms / surgery. Fibromatosis, Aggressive / surgery

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  • (PMID = 19911489.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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6. Bertani E, Chiappa A, Testori A, Mazzarol G, Biffi R, Martella S, Pace U, Soteldo J, Vigna PD, Lembo R, Andreoni B: Desmoid tumors of the anterior abdominal wall: results from a monocentric surgical experience and review of the literature. Ann Surg Oncol; 2009 Jun;16(6):1642-9
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  • [Title] Desmoid tumors of the anterior abdominal wall: results from a monocentric surgical experience and review of the literature.
  • BACKGROUND: Desmoid tumor, also known as aggressive fibromatosis, is a rare soft tissue tumor.
  • For those cases localized in the anterior abdominal wall, radical resection and reconstruction with a mesh is indicated.
  • Because the rarity of the disease, randomized trials are lacking, but in reported retrospective series, it is clear that although it is considered a benign lesion, local recurrence is not uncommon.
  • METHODS: We analyzed the records of 14 consecutive patients (3 men, 11 women, mean age 36 years, range 25-51 years) with desmoid tumor of the anterior abdominal wall treated at the European Institute of Oncology.
  • The surgical strategy was the same in all cases: wide surgical excision and immediate plastic reconstruction with mesh after intraoperative confirmation by frozen sections of disease-free margins of >1 cm.
  • CONCLUSIONS: Radical resection aided by intraoperative margin evaluation via frozen sections followed by immediate mesh reconstruction is a safe procedure and can provide definitive cure without functional limitations for patients with desmoid tumors of the anterior abdominal wall.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Abdominal Wall. Adult. Female. Humans. Male. Middle Aged. Surgical Mesh

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  • (PMID = 19296178.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Polat C, Aktepe F, Turel S, Yazicioglu B, Ozkececi T, Arikan Y: A giant mesenteric fibromatosis case presenting with mechanical intestinal obstruction and successfully resected with partial duodeno-jejunectomy and right hemicolectomy. Clinics (Sao Paulo); 2010;65(1):110-3
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  • [Title] A giant mesenteric fibromatosis case presenting with mechanical intestinal obstruction and successfully resected with partial duodeno-jejunectomy and right hemicolectomy.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Intestinal Obstruction / etiology. Mesentery / pathology. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Colectomy / methods. Diagnosis, Differential. Duodenum / surgery. Humans. Jejunum / surgery. Male. Middle Aged

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  • (PMID = 20126354.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC2815273
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8. Maseelall P, Robins JC, Williams DB, Thomas MA: Stabilization and regression of a recurrent desmoid tumor with the antiestrogen toremifene. Fertil Steril; 2005 Aug;84(2):509
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stabilization and regression of a recurrent desmoid tumor with the antiestrogen toremifene.
  • OBJECTIVE: To report a case of a pelvic desmoid tumor that was treated with the antiestrogen toremifene after a failed attempt at surgical excision.
  • PATIENT(S): A reproductive-aged woman with a recurrent desmoid tumor.
  • INTERVENTION(S): After surgical excision of a desmoid tumor that presented during childbirth, subsequent recurrence resulted in the use of toremifene for tumor stabilization.
  • MAIN OUTCOME MEASURE(S): Magnetic resonance imaging was used to monitor desmoid tumor size.
  • RESULT(S): One year after postsurgical recurrence of the desmoid tumor, the patient began treatment with the antiestrogen toremifene.
  • Tumor stabilization and regression with symptomatic relief was observed.
  • Nine years of antiestrogen use revealed no progression in tumor size or patient symptoms.
  • After the patient demonstrated perimenopausal symptoms, toremifene administration was discontinued without a return of symptoms or tumor growth after 3 years.
  • CONCLUSION(S): Our case demonstrates that toremifene is a safe and effective therapy that can be used for the stabilization and regression of desmoid tumors.
  • An antiestrogen should be considered as adjuvant therapy after surgery and as a first-line treatment with disease recurrence.
  • [MeSH-major] Estrogen Antagonists / therapeutic use. Fibromatosis, Abdominal / drug therapy. Fibromatosis, Aggressive / drug therapy. Neoplasm Recurrence, Local / prevention & control. Toremifene / therapeutic use

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  • (PMID = 16086575.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 7NFE54O27T / Toremifene
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9. Doi J, Morita S: A case of mesenteric desmoid tumor of the jejunum. Jpn J Clin Oncol; 2009 Dec;39(12):859
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of mesenteric desmoid tumor of the jejunum.
  • [MeSH-major] Fibromatosis, Abdominal / epidemiology. Peritoneal Neoplasms / epidemiology

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  • (PMID = 19942588.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Achach T, Rammeh S, Trabelsi A, Ltaief R, Ben Abdelkrim S, Mokni M, Korbi S: Clear cell adenocarcinoma arising from abdominal wall endometriosis. J Oncol; 2008;2008:478325
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clear cell adenocarcinoma arising from abdominal wall endometriosis.
  • Endometriosis is a frequent benign disorder.
  • A 49-year-old woman is presented with a large painful abdominal wall mass.
  • Computed tomography suggested that this was a desmoid tumor and she underwent surgery.
  • Six months later, she returned with a recurrence of the abdominal wall mass.

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  • (PMID = 19266089.001).
  • [ISSN] 1687-8450
  • [Journal-full-title] Journal of oncology
  • [ISO-abbreviation] J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2648644
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11. Holubar S, Dwivedi AJ, O'Connor J: Giant mesenteric fibromatosis presenting as small bowel obstruction. Am Surg; 2006 May;72(5):427-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mesenteric fibromatosis presenting as small bowel obstruction.
  • Mesenteric fibromatosis is a proliferative fibroblastic neoplasia of the small intestine mesentery that may occur as a unique or multiple formation.
  • Mesenteric fibromatosis is a rare, locally aggressive neoplasm and may present with abdominal discomfort, abdominal pain, weight loss, or symptoms of ureteral obstruction, mesenteric ischemia, or intestinal obstruction.
  • It is of the utmost importance to distinguish mesenteric fibromatosis from gastrointestinal stromal tumors.
  • The involvement of important structures like the superior mesenteric artery and the superior mesenteric vein may pose a challenge during resection, but these tumors can be excised and the vessels repaired primarily.
  • [MeSH-major] Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / diagnosis. Intestinal Obstruction / etiology
  • [MeSH-minor] Diagnosis, Differential. Gastrointestinal Stromal Tumors / pathology. Humans. Male. Mesentery. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16719198.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Giuliani A, Demoro M, Ciardi A, Scimó M, Galati F, Lonardo MT, Galati G: Mesenteric fibromatosis. Case report. J Exp Clin Cancer Res; 2007 Sep;26(3):425-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric fibromatosis. Case report.
  • Deep fibromatosis is a rare locally aggressive but not metastasizing proliferation.
  • Intra-abdominal fibromatosis (IAF) occurs either in association with Gardner's syndrome or as a sporadic event and presents in most cases differential diagnostic problems with myofibroblastic or fibroblastic tumors, characterized by a more aggressive biological behaviour such as gastrointestinal stromal tumors (GISTs).
  • In absence of loco-regional and/or distant metastasis differential diagnosis may be difficult and represents a topical issue, since it influences treatment choice.
  • We describe the case of a patient with sporadic IAF in which the tumor locally involved the mesentery and presented no loco-regional and distant spread.
  • Definitive diagnosis was made, postoperatively, on the basis of immunohistochemical findings.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibroma / diagnosis. Mesentery
  • [MeSH-minor] Diagnosis, Differential. Gardner Syndrome / pathology. Humans. Male. Middle Aged

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  • (PMID = 17987807.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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13. Picariello L, Carbonell Sala S, Martineti V, Gozzini A, Aragona P, Tognarini I, Paglierani M, Nesi G, Brandi ML, Tonelli F: A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells. Anal Biochem; 2006 Jul 15;354(2):205-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells.
  • These tumors may be sporadic or associated with a genetic disease such as familial adenomatous polyposis (FAP).
  • Although surgery is widely accepted as the first-line treatment for extra-abdominal and abdominal wall desmoids, a proportion of cases are successfully palliated with either estrogen antagonists (tamoxifen, toremifene, and raloxifene) or nonsteroidal anti-inflammatory drugs.
  • We describe and compare four methods for evaluating the expression of estrogen receptors alpha/beta and COX-1 and COX-2 in desmoid tumor-derived cells and tissues: immunocytochemistry, immunohistochemistry, RT-PCR, and two-color Western blot detection with the Odyssey infrared imaging system.
  • Through this comparative analysis, Western blot with Odyssey was recognized as the best method to analyze the expression particularly of low expressed proteins in desmoid-derived cells.
  • [MeSH-major] Fibromatosis, Aggressive / metabolism. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism
  • [MeSH-minor] Base Sequence. Blotting, Western. Cyclooxygenase 1 / analysis. Cyclooxygenase 1 / genetics. Cyclooxygenase 1 / metabolism. Cyclooxygenase 2 / analysis. Cyclooxygenase 2 / genetics. Cyclooxygenase 2 / metabolism. Estrogen Receptor alpha / analysis. Estrogen Receptor alpha / genetics. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / analysis. Estrogen Receptor beta / genetics. Estrogen Receptor beta / metabolism. Gene Expression. Humans. Immunohistochemistry. Membrane Proteins / analysis. Membrane Proteins / genetics. Membrane Proteins / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 16729958.001).
  • [ISSN] 0003-2697
  • [Journal-full-title] Analytical biochemistry
  • [ISO-abbreviation] Anal. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS1 protein, human; EC 1.14.99.1 / PTGS2 protein, human
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14. Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, Bousdras K, Diss TC, O'Donnell P, Flanagan AM: Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. Am J Surg Pathol; 2007 Sep;31(9):1299-309
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  • [Title] Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool.
  • Desmoid-type fibromatosis is a locally aggressive deep soft tissue tumor.
  • The aim of this study was to determine the specificity and sensitivity of these 3 most common beta-catenin mutations in the diagnosis of desmoid-type fibromatosis using paraffin-embedded material.
  • One hundred and thirty-three cases were analyzed, including 76 desmoid-type, and 18 superficial fibromatosis, in addition to a further 39 fibromatosis mimics.
  • Mutations were detected in 66 cases (87%) of 76 desmoid-type fibromatosis (71 extra-abdominal).
  • All desmoid-type fibromatosis cases and 72% of the mimics tested showed nuclear positivity for beta-catenin indicating immunohistochemistry is a sensitive but not a specific test for desmoid-type fibromatosis.
  • In contrast, to date, beta-catenin mutations have not been detected in any lesions which mimic desmoid-type fibromatosis.
  • Mutation-specific restriction enzyme digestion, a simple and efficient means of detecting the common beta-catenin mutations in desmoid-type fibromatosis, complements light microscopy in reaching a diagnosis.
  • [MeSH-major] DNA Mutational Analysis / methods. Fibromatosis, Aggressive / diagnosis. Gene Expression Regulation, Neoplastic. Mutation. Restriction Mapping. beta Catenin / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Base Sequence. Cell Nucleus / chemistry. Child. Codon. Diagnosis, Differential. Female. Humans. Immunohistochemistry / methods. Magnetic Resonance Imaging. Male. Middle Aged. Molecular Sequence Data. Paraffin Embedding. Predictive Value of Tests. Sensitivity and Specificity. Tissue Array Analysis

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  • (PMID = 17721184.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CTNNB1 protein, human; 0 / Codon; 0 / beta Catenin
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15. Tiwari A, Topno M, Karim T, Sharma V: A rare case of desmoid tumor of thigh. Indian J Surg; 2010 Oct;72(5):409-11
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  • [Title] A rare case of desmoid tumor of thigh.
  • Extraabdominal desmoid tumor is a locally aggressive tumor despite being histologically benign.
  • To avoid local recurrence, it is important to preoperatively detect the exact localization and extension of the infiltrating or disseminating lesion in this tumor.
  • We report a case of recurrent extraabdominal desmoid tumor, which arose in the posterior thigh region.
  • On investigation he was found to be case of desmoid tumor of thigh.

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  • [Cites] J Radiol. 2002 Jun;83(6 Pt 1):711-6 [12149587.001]
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  • (PMID = 21966144.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3077143
  • [Keywords] NOTNLM ; Extra abdominal desmoid / Surgical excision / Thigh swelling
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16. Sun L, Wu H, Zhuang YZ, Guan YS: A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us? World J Gastroenterol; 2007 Mar 14;13(10):1632-5
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  • [Title] A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us?
  • Mesenteric fibromatosis is a rare benign nonmetastatic neoplasm that appears as a sporadic lesion or occurs in patients with familial polyposis, while chylous ascites associated with aggressive mesenteric fibromatosis during pregnancy has never been reported thus far.
  • Here we present the case of a 28-year old pregnant woman, in whom an aggressive mesenteric fibromatosis with chylous ascites was detected, involving the jejunum, superior mesenteric artery (SMA) and superior mesenteric vein (SMV) and pancreas.
  • The authors report the case for its rarity and emphasize on combining clinicopathological, radiological and immunohistochemistry analysis for management of the disease.
  • [MeSH-major] Chylous Ascites / etiology. Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / diagnosis. Pregnancy Complications / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Mesentery / pathology. Mesentery / radiography. Peritoneal Neoplasms / complications. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology. Pregnancy. Tomography, Spiral Computed

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  • [Cites] Histopathology. 2001 May;38(5):387-402 [11422475.001]
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  • (PMID = 17461463.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4146913
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17. Joyner DE, Trang SH, Damron TA, Aboulafia AJ, Cummings JE, Randall RL: Desmoid cell motility is induced in vitro by rhEGF. J Orthop Res; 2009 Sep;27(9):1258-62
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  • [Title] Desmoid cell motility is induced in vitro by rhEGF.
  • Desmoid tumors are benign but locally invasive myofibroblastic lesions that arise predominantly in the abdominal wall or shoulder and are prone to aggressive local recurrences.
  • A perceived association between desmoid activity and the expression of growth factors during pregnancy or following trauma suggests a cause-and-effect relationship between growth factor stimulation and desmoid invasiveness.
  • We used Boyden Chambers to quantify cell motility in order to determine the effect of growth factor stimulation on desmoid cell migration.
  • Desmoid cell cultures were treated under serum-free conditions with epidermal growth factor (rhEGF) or transforming growth factor alpha (rhTGFalpha).
  • The experiments demonstrated a direct dose-dependent relationship between rhEGF stimulation and desmoid motility.
  • [MeSH-major] Cell Movement / drug effects. Epidermal Growth Factor / pharmacology. Fibromatosis, Aggressive / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Antigens, CD29 / genetics. Benzamides / pharmacology. Cell Division / drug effects. Cell Line, Tumor. Culture Media, Serum-Free / pharmacology. Dioxoles / pharmacology. Enzyme Inhibitors / pharmacology. Gene Expression Regulation, Neoplastic. Humans. In Vitro Techniques. Matrix Metalloproteinase 1 / genetics. Matrix Metalloproteinase 3 / genetics. Quinazolines. RNA, Messenger / metabolism. RNA, Small Interfering. Receptor, Epidermal Growth Factor / genetics. Receptors, Transforming Growth Factor beta / antagonists & inhibitors. Recombinant Proteins / pharmacology. STAT3 Transcription Factor / genetics. Transforming Growth Factor alpha / genetics. Transforming Growth Factor alpha / pharmacology. Tyrphostins / pharmacology

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  • [Copyright] (c) 2009 Orthopaedic Research Society.
  • (PMID = 19242968.001).
  • [ISSN] 1554-527X
  • [Journal-full-title] Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • [ISO-abbreviation] J. Orthop. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide; 0 / Antigens, CD29; 0 / Benzamides; 0 / Culture Media, Serum-Free; 0 / Dioxoles; 0 / Enzyme Inhibitors; 0 / Quinazolines; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Receptors, Transforming Growth Factor beta; 0 / Recombinant Proteins; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / Transforming Growth Factor alpha; 0 / Tyrphostins; 170449-18-0 / tyrphostin AG 1478; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.7 / Matrix Metalloproteinase 1
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18. Soravia C, DeLozier CD, Dobbie Z, Berthod CR, Arrigoni E, Bründler MA, Blouin JL, Foulkes WD, Hutter P: Double frameshift mutations in APC and MSH2 in the same individual. Int J Colorectal Dis; 2006 Jan;21(1):79-83
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  • The number of polyps (less than ten) was not typical of polyposis; therefore, the diagnosis of HNPCC was entertained.
  • The tumor tissue showed high-grade instability, and a subsequent, immunohistochemistry showed that neither MSH2 nor MSH6 proteins were expressed in tumor cells.
  • The patient later developed an intra-abdominal desmoid tumor.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Frameshift Mutation. Genes, APC. Genetic Predisposition to Disease. MutS Homolog 2 Protein / genetics
  • [MeSH-minor] Adult. Colectomy. Diagnosis, Differential. Germ-Line Mutation. Humans. Male. Pedigree

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  • [RepublishedFrom] Int J Colorectal Dis. 2005 Sep;20(5):466-470 [15834612.001]
  • (PMID = 16676398.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Corrected and Republished Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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19. Dalal AK, Singal R, Dalal U, Attri AK, Sahu P, Gupta A: An unusual case of chest wall desmoid tumor. Indian J Surg; 2010 Jul;72(Suppl 1):336-8
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  • [Title] An unusual case of chest wall desmoid tumor.
  • Desmoid tumor of the chest wall are uncommon fibromatous tumors characterized by their local invasion and frequent recurrences.
  • Extra-abdominal sites are mainly the shoulder girdle, the pelvic girdle and distal ends of the lower limbs.
  • The chest wall represents 8-10% of cases and the tumor is exceptionally intrathoracic.
  • We present here a rare case of a large desmoid tumor of left antero-lateral chest wall.
  • In the presented case, wide excision of the tumor and chest wall reconstruction was done.

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  • [Cites] Plast Reconstr Surg. 1991 May;87(5):956-60 [2017508.001]
  • [Cites] Ann Surg. 1999 Jun;229(6):866-72; discussion 872-3 [10363901.001]
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  • (PMID = 23133290.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451859
  • [Keywords] NOTNLM ; Chest wall / Extra abdominal tumor / Surgery
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20. Barbier O, Anract P, Pluot E, Larouserie F, Sailhan F, Babinet A, Tomeno B: Primary or recurring extra-abdominal desmoid fibromatosis: assessment of treatment by observation only. Orthop Traumatol Surg Res; 2010 Dec;96(8):884-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary or recurring extra-abdominal desmoid fibromatosis: assessment of treatment by observation only.
  • INTRODUCTION: Extra-abdominal desmoid fibromatosis (EADF) is a benign tumoral condition, classically managed by more or less radical and sometimes mutilating excision.
  • One primary tumor showed spontaneous regression, and one recurrence still showed evolution at end of follow-up (23 months).
  • [MeSH-major] Fibroma / therapy. Fibromatosis, Aggressive / therapy. Neoplasm Recurrence, Local / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Observation. Retrospective Studies. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21075698.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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21. Kouchi M, Okimoto K, Matsumoto I, Michimae Y, Yamada T, Inoue T, Kimura T, Seki T, Yasuba M, Hino O: Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat. Exp Toxicol Pathol; 2008 Mar;59(5):273-9
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  • [Title] Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat.
  • Fibromatosis-type fibromas were found to develop at abdominal surgical sites in 4 heterozygous Nihon rats, a model for the human Birt-Hogg-Dubé syndrome.
  • In all 4 rats, solitary and firm nodules were located within the lateral abdominal musculature involving the full thickness of the abdominal wall at the sites of laparotomy.
  • These cells were surrounded by large amounts of collagen fibers, and appeared to infiltrate within the abdominal musculature.
  • These characteristics are consistent with desmoid tumors in human.
  • Although the etiology of desmoid tumors in human remains unclear, they are known to occur in association with hormonal factors, surgical trauma, and familial adenomatous polyposis.
  • Genetic factor should be involved in the occurrence of the tumor, since it was found only in the Nihon rats among many rats.
  • [MeSH-minor] Animals. Disease Models, Animal. Mutation. Rats. Rats, Mutant Strains

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  • (PMID = 18036795.001).
  • [ISSN] 0940-2993
  • [Journal-full-title] Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie
  • [ISO-abbreviation] Exp. Toxicol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Flcn protein, rat; 0 / Proteins
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22. Rosoff PM, Larrier N, Rice HE: Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease. Pediatr Blood Cancer; 2005 Oct 15;45(5):728-31
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  • [Title] Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease.
  • The risk of second malignancies after successful treatment for Hodgkin disease can be considerable.
  • We describe a young woman who developed an intra-abdominal desmoid tumor more than 4 years after completing therapy for Stage IIB Hodgkin disease, treated with combination chemotherapy (ABVD) and mantle irradiation.
  • The tumor did not occur at either a surgical site or within a radiation field.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibromatosis, Aggressive / diagnosis. Hodgkin Disease / therapy. Neoplasms, Second Primary / diagnosis

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  • (PMID = 16035093.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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23. Ferenc T, Sygut J, Tosik D, Kopczyński J, Sidor M, Góźdź S, Kulig A, Dziki A, Turant M, Stalińska L: Analysis of p27KIP1 protein and Ki-67 expression in aggressive fibromatosis (desmoid tumor). Pol J Pathol; 2006;57(4):187-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of p27KIP1 protein and Ki-67 expression in aggressive fibromatosis (desmoid tumor).
  • Aggressive fibromatosis (desmoid tumor) is an uncommon locally invasive non-metastasizing neoplasm lesion.
  • Desmoid tumor consists of fibroblasts, miofibroblasts and a significant amount of extracellular matrix. p27KIP1 (p27) protein is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family that regulates progression through the cell cycle.
  • There were analysed 42 specimens of aggressive fibromatosis, in which there were 24 abdominal and 18 extra-abdominal cases.
  • There was no statistically significant difference between Ki-67 or p27 expression in abdominal and extra-abdominal location.
  • Analysis of p27 and Ki-67 expression levels might indicate that low proliferating activity of desmoid fibroblasts is connected with another mechanism than the one, in which p27 takes part.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Fibromatosis, Abdominal / metabolism. Ki-67 Antigen / metabolism

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  • (PMID = 17285761.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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24. Schlager A, Altchek A, Kalir T, Deligdisch L, Weber KJ: Mesenteric fibromatosis masquerading as an ovarian neoplasm twenty years after Chernobyl radiation exposure. Gynecol Oncol; 2006 Sep;102(3):587-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric fibromatosis masquerading as an ovarian neoplasm twenty years after Chernobyl radiation exposure.
  • BACKGROUND: Since their initial description in 1832, desmoid tumors have been reported to occur in virtually every part of the body.
  • Intra-abdominal desmoid tumors, or mesenteric fibromatosis, are often associated with Familial Adenomatous Polyposis mutation in a syndrome known as Gardner's Syndrome.
  • Although sporadic cases of desmoid tumors do occur, unlike Gardner's Syndrome, they predominantly occur extra-abdominally.
  • CASE: Case report of a 61-year-old female who presented with two months of abdominal pain, progressive lower abdominal distension and a 10-15 pound weight gain accompanied by one week of urinary hesitancy and frequency.
  • Patient underwent a diagnostic workup for an ovarian neoplasm, but was found at surgery to have mesentric fibromatosis.
  • CONCLUSION: Although uncommon, mesentric fibromatosis must be considered in the differential diagnosis when evaluating a patient with an abdominal mass of unknown origin.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Aggressive / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Power Plants. Radioactive Hazard Release. Ukraine

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  • (PMID = 16678243.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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25. Kreuzberg B, Koudelova J, Ferda J, Treska V, Spidlen V, Mukensnabl P: Diagnostic problems of abdominal desmoid tumors in various locations. Eur J Radiol; 2007 May;62(2):180-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic problems of abdominal desmoid tumors in various locations.
  • BACKGROUND: Abdominal desmoid tumor is one of the forms of deep (musculoaponeurotic) fibromatosis.
  • It occurs more often as a desmoid tumor in the abdominal wall, less often in various intra-abdominal locations.
  • In this work, we performed retrospective study concerning diagnostic problems of this disease with the use of imaging techniques.
  • RESULTS: The findings were typical only in the case with the lesion located in the abdominal wall, three described cases of the intra-abdominal desmoid provided a broad range of differentially diagnostic possibilities (metastases, GIT tumors, lymphomas, etc.).
  • In particular, the findings in infiltrative processes in intra-abdominal location and retroperitoneal involvement were less typical.
  • CONCLUSION: The possibility of the occurrence of intra-abdominal desmoid tumor must be considered particularly in younger individuals with rapidly growing tumorous process, which does not immediately arise from the surrounding organs (digestive tract, internal genitalia, etc.
  • ), and is located in the abdominal wall or in the abdominal cavity.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Aggressive / diagnosis
  • [MeSH-minor] Abdominal Cavity / pathology. Abdominal Wall / pathology. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17321093.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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26. Bölke E, Krasniqi H, Lammering G, Engers R, Matuschek C, Gripp S, Gerber PA, Fischer G, Peiper M, Shaikh S, Budach W, Orth K: Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature. Eur J Med Res; 2009 Jun 18;14(6):240-3
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  • [Title] Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature.
  • Desmoid tumors are fibroblastic/myofibroblastic neoplasms, which originate from musculo-aponeurotic structures and are classified as deep fibromatoses.
  • Despite their benign histologic appearance and lack of metastatic potential, desmoid tumors may cause aggres?sive local infiltrations and compression of surrounding structures.
  • Radical tumor resection with free margins remains the first therapy of choice.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Thoracic Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 19541583.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC3352015
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27. Viriyaroj V, Yingsakmongkol N, Pasukdee P, Rermluk N: A large abdominal desmoid tumor associated with pregnancy. J Med Assoc Thai; 2009 Jun;92 Suppl 3:S72-5
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  • [Title] A large abdominal desmoid tumor associated with pregnancy.
  • Desmoid tumors are rare, benign tumors with locally aggressive behavior which originate from fascial or musculoaponeurotic structure.
  • The etiology of desmoid tumors are uncertain but may be related to operation, trauma or hormonal factors.
  • The authors report a 17-year old woman, gravida 1, para 1 with a mass at her lower abdominal wall during the fifth month of gestation.
  • She was biopsied during delivery in another hospital but was not given a definite diagnosis.
  • The tumor measured 28 x 21 x 18 centimeters in size and 4,900 g in weight.
  • Complete surgical excision was performed The pathological report was desmoid tumor (aggressive fibromatosis).
  • She had no post-operative complication and no recurrent tumor in the 8 months after operation.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibromatosis, Aggressive / diagnosis. Pregnancy Complications

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  • (PMID = 19702071.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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28. Janitzky A, Porsch M, Daher M, Küster D, Liehr UB: [Aggressive fibromatosis (desmoid tumor) : A rare differential diagnosis of metastasis of renal cell carcinoma]. Urologe A; 2010 Jan;49(1):81-3
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  • [Title] [Aggressive fibromatosis (desmoid tumor) : A rare differential diagnosis of metastasis of renal cell carcinoma].
  • [Transliterated title] Aggressive Fibromatose (Desmoidfibromatose) : Seltene Differentialdiagnose einer Nierenzellkarzinommetastase.
  • We report the case of a 65-year-old woman with an aggressive fibromatosis of the rectus abdominis muscle suspicious for a metastasis of renal cell carcinoma after tumor nephrectomy 3 years previously.
  • Aggressive fibromatoses (desmoid tumors) are rare semimalignant tumors of the connective tissue with local infiltration and destruction of tissue.
  • Complete resection is essential to avoid tumor relapse.
  • Aggressive fibromatosis must be considered in the differential diagnosis of renal cell carcinoma metastasis.
  • [MeSH-major] Abdominal Muscles / pathology. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Fibromatosis, Abdominal / diagnosis. Kidney Neoplasms / diagnosis. Muscle Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans


29. Leal RF, Silva PV, Ayrizono Mde L, Fagundes JJ, Amstalden EM, Coy CS: Desmoid tumor in patients with familial adenomatous polyposis. Arq Gastroenterol; 2010 Oct-Dec;47(4):373-8
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  • [Title] Desmoid tumor in patients with familial adenomatous polyposis.
  • CONTEXT: Desmoid tumors constitute one of the most important extraintestinal manifestations of familial adenomatous polyposis.
  • OBJECTIVES: To evaluate the occurrence of desmoid tumors in familial adenomatous polyposis cases following prophylactic colectomy and to present patient outcome.
  • Desmoid tumors were found in nine (13.2%) of these patients, who were studied retrospectively by consulting their medical charts with respect to clinical and surgical data.
  • RESULTS: Of nine patients, seven (77.8%) were submitted to laparotomy for tumor resection.
  • Desmoid tumors were found in the abdominal wall in 3/9 cases (33.3%) and in an intra-abdominal site in the remaining six cases (66.7%).
  • Median time elapsed between ileal pouch-anal anastomosis and diagnosis of desmoid tumor was 37.5 months (range 14-60 months), while the median time between colectomy with ileorectal anastomosis and diagnosis was 63.7 months (range 25-116 months).
  • In 6/9 (66.7%) patients with desmoid tumors, the disease was either under control or there was no evidence of tumor recurrence at a follow-up visit made a mean of 63.1 months later (range 12-240 months).
  • CONCLUSIONS: Desmoid tumors were found in 13.2% of cases of familial adenomatous polyposis following colectomy; therefore, familial adenomatous polyposis patients should be followed-up and surveillance should include abdominal examination to detect signs and symptoms.
  • [MeSH-major] Abdominal Neoplasms / surgery. Colectomy. Fibromatosis, Abdominal / surgery. Fibromatosis, Aggressive / surgery
  • [MeSH-minor] Abdominal Wall / surgery. Adult. Anastomosis, Surgical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome. Young Adult


30. Iwasa T, Sadamoto Y, Itaba S, Nasu T, Ihara Y, Misawa T, Nakamura K: [A case of mesenteric desmoid tumor]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jun;104(6):804-8
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  • [Title] [A case of mesenteric desmoid tumor].
  • Abdominal computed tomography showed a tumor, about 5 cm in diameter at the duodeno-jejunal junction.
  • The preoperative diagnosis was submucosal or mesenteric tumor.
  • The tumor derived from the mesenterium and involved the anal side of the small intestine.
  • The tumor was removed with partial excision of the upper jejunum.
  • The diagnosis of mesenteric desmoid tumor was confirmed, histologically.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Ileus / etiology. Mesentery. Peritoneal Neoplasms / diagnosis

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  • (PMID = 17548947.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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31. Grouwels P, Verswijvel G, Vandevenne J, Palmers Y: Abdominal wall desmoid tumor. JBR-BTR; 2007 May-Jun;90(3):190-1
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  • [Title] Abdominal wall desmoid tumor.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibroma / diagnosis

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  • (PMID = 17696091.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Contrast Media
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32. Liegl B, Leithner A, Bauernhofer T, Windhager R, Guelly C, Regauer S, Beham A: Immunohistochemical and mutational analysis of PDGF and PDGFR in desmoid tumours: is there a role for tyrosine kinase inhibitors in c-kit-negative desmoid tumours? Histopathology; 2006 Dec;49(6):576-81
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  • [Title] Immunohistochemical and mutational analysis of PDGF and PDGFR in desmoid tumours: is there a role for tyrosine kinase inhibitors in c-kit-negative desmoid tumours?
  • AIM: To determine the platelet-derived growth factor (PDGF) alpha and beta status of desmoid tumours.
  • Desmoid tumours are rare monoclonal neoplasms that appear to have no metastatic potential.
  • Therapy with Imatinib has been proposed as a therapeutic option, although in most reports desmoid tumours are reported to be c-kit-.
  • METHODS AND RESULTS: We performed immunohistochemical analysis on 124 archived samples (85 patients) of desmoid tumours using antibodies to PDGFalpha, PDGFbeta, PDGFRalpha and PDGFRbeta.
  • All desmoid tumours showed immunoreactivity with antibodies to PDGFalpha and PDGFRalpha, whereas with antibodies to PDGFbeta and PDGFRbeta no specific reaction could be detected.
  • CONCLUSION: The absence of an activating mutation in a protooncogene does not exclude the efficacy of tyrosine kinase inhibitors through other possible mechanisms, and these might be a therapeutic option for patients with desmoid tumours in whom established local and systemic approaches fail to control the disease.
  • [MeSH-major] Enzyme Inhibitors / metabolism. Fibromatosis, Abdominal / metabolism. Platelet-Derived Growth Factor / metabolism. Protein-Tyrosine Kinases / antagonists & inhibitors. Proto-Oncogene Proteins c-kit / metabolism. Receptors, Platelet-Derived Growth Factor / metabolism
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. DNA Mutational Analysis. DNA, Neoplasm / analysis. Female. Humans. Immunohistochemistry / methods. Male. Proto-Oncogene Proteins c-sis / genetics. Proto-Oncogene Proteins c-sis / metabolism. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Receptor, Platelet-Derived Growth Factor beta / metabolism

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  • (PMID = 17163842.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Enzyme Inhibitors; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / platelet-derived growth factor A; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta; EC 2.7.10.1 / Receptors, Platelet-Derived Growth Factor
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33. Bhattacharya B, Dilworth HP, Iacobuzio-Donahue C, Ricci F, Weber K, Furlong MA, Fisher C, Montgomery E: Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions. Am J Surg Pathol; 2005 May;29(5):653-9
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  • [Title] Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions.
  • Deep fibromatoses (desmoid tumors) are clonal myofibroblastic proliferations that are prone to aggressive local recurrences but that do not metastasize.
  • Virtually all deep fibromatoses have somatic beta-catenin or adenomatous polyposis coli (APC) gene mutations leading to intranuclear accumulation of beta-catenin.
  • Since low-grade sarcomas in general lack beta-catenin and since reactive proliferations would not be expected to have it, we predicted that nuclear beta-catenin expression would be detected in deep fibromatoses but absent in other entities in the differential diagnosis.
  • We evaluated the role of beta-catenin to help differentiate distinguish deep fibromatoses from congeners.
  • Formalin-fixed, paraffin-embedded sections from 21 lesions from 20 patients with deep fibromatoses were stained with monoclonal beta-catenin antibody (Transduction Laboratories) and compared with low-grade fibromyxoid sarcoma (n=12), leiomyosarcoma (n=10), various other fibrosarcoma variants (n=13, including 3 myofibrosarcomas, 3 sclerosing epithelioid fibrosarcomas, 5 low-grade fibrosarcomas, 1 classic fibrosarcoma arising in dermatofibrosarcoma protuberans, 1 inflammatory myxohyaline tumor/myxoinflammatory fibroblastic sarcoma), myofibroma/myofibromatosis (n=12), nodular fasciitis (n=11), and scars (n=9).
  • All 21 examples of deep fibromatosis displayed nuclear beta-catenin (focal nuclear staining in one case to 90% staining).
  • All other lesions tested (n=67) lacked nuclear labeling for beta-catenin, showing only cytoplasmic accumulation. beta-Catenin immunohistochemistry separates deep fibromatosis from entities in the differential diagnosis, a finding that can be exploited for diagnosis.
  • Most fibromatoses have diffuse nuclear staining although occasional examples only focally label.
  • [MeSH-major] Cell Nucleus / pathology. Cytoskeletal Proteins / metabolism. Fibroblasts / pathology. Fibromatosis, Abdominal / pathology. Sarcoma / pathology. Trans-Activators / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Child. Cicatrix / metabolism. Cicatrix / pathology. Cytoplasm / metabolism. Cytoplasm / pathology. Diagnosis, Differential. Fasciitis / metabolism. Fasciitis / pathology. Female. Humans. Male. Middle Aged. beta Catenin

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  • (PMID = 15832090.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Cytoskeletal Proteins; 0 / Trans-Activators; 0 / beta Catenin
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34. Michopoulou A, Germanos S, Kanakopoulos D, Milonas A, Orfanos N, Spyratou C, Markidis P: Management of a large abdominal wall desmoid tumor during pregnancy. Case report. Ann Ital Chir; 2010 Mar-Apr;81(2):153-6
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  • [Title] Management of a large abdominal wall desmoid tumor during pregnancy. Case report.
  • Desmoid tumors, characterized by aggressive local infiltration of surrounding tissues, are uncommon benign neoplasms with no metastatic potential, that occasionally may attain large size.
  • We report a case of a 37-year-old woman with an abdominal wall desmoid tumor that appeared and grew rapidly during her pregnancy, diagnosed by trucut core biopsy.
  • Complete surgical excision of a 20 x 16 cm in size tumor and immediate reconstruction with mesh was performed in the postpartum period.
  • Optimal management of large abdominal wall desmoids during pregnancy has to be individualized, with wide surgical excision remaining the treatment of choice.
  • [MeSH-major] Abdominal Wall. Fibromatosis, Aggressive / surgery. Pregnancy Complications, Neoplastic / surgery


35. Stoidis CN, Spyropoulos BG, Misiakos EP, Fountzilas CK, Paraskeva PP, Fotiadis CI: Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report. J Med Case Rep; 2010;4:314
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  • [Title] Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report.
  • INTRODUCTION: Intra-abdominal fibromatosis, usually located at the mesenteric level, is a locally invasive tumor of fibrous origin, with no ability to metastasize, but a tendency to recur.
  • Certain non-typical cases of intra-abdominal fibromatosis with involvement of the bowel wall can be misdiagnosed because of their different biological behavior.
  • CASE PRESENTATION: We describe the case of a 64-year-old Caucasian man presenting with mesenteric fibromatosis and involvement of the bowel wall, who was treated surgically.
  • The macroscopic and microscopic appearance of the lesion mimicked a gastrointestinal stromal tumor, a tumor with potential malignant behavior.
  • CONCLUSION: It is essential to make an early and correct diagnosis in such equivocal cases, so that the appropriate treatment can be chosen and suitable patients admitted to clinical trials if appropriate.
  • New and reliable criteria for discriminating between intra-abdominal fibromatosis and gastrointestinal stromal tumor should be proposed and established because novel sophisticated therapeutic strategies have been introduced in the international literature.

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  • (PMID = 20863383.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2955058
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36. Barrera E, García A, Ferrufino J: [Desmoid tumor: report of a case]. Rev Gastroenterol Peru; 2005 Jul-Sep;25(3):288-90
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  • [Title] [Desmoid tumor: report of a case].
  • [Transliterated title] Tumor desmoide: reporte de un caso.
  • The desmoid tumor is a solid tumor with soft parts and with various possible locations.
  • The diagnosis was made by pathological anatomy.
  • [MeSH-major] Fibromatosis, Abdominal
  • [MeSH-minor] Diagnosis, Differential. Duodenal Obstruction / diagnosis. Duodenal Obstruction / etiology. Duodenal Obstruction / pathology. Duodenal Obstruction / radiography. Duodenal Obstruction / surgery. Duodenum / pathology. Female. Humans. Middle Aged

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  • (PMID = 16237475.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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37. Perenze B, Potì O, Margiotta A, Rega D, Marrano N, Minni F: [Mesenteric fibromatosis]. Chir Ital; 2005 Nov-Dec;57(6):717-22
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  • [Title] [Mesenteric fibromatosis].
  • [Transliterated title] La fibromatosi mesenterica.
  • Mesenteric fibromatosis is a rare benign mesenteric tumour, characterised by infiltrative growth and high rates of recurrence.
  • Histological examination is the only diagnostic procedure capable of ruling out a malignant mesenteric neoplasm.
  • It is not always possible to perform a radical removal of the tumour mass because it may have infiltrated important anatomical structures.
  • In the present study the Authors report two cases of mesenteric fibromatosis and analyse the main clinical-diagnostic, therapeutic and prognostic problems posed by these tumours.

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  • (PMID = 16400766.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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38. Santos GA, Cunha IW, Rocha RM, Mello CA, Guimarães GC, Fregnani JH, Lopes A: Evaluation of estrogen receptor alpha, estrogen receptor beta, progesterone receptor, and cKIT expression in desmoids tumors and their role in determining treatment options. Biosci Trends; 2010 Feb;4(1):25-30
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  • Fifty-nine cases classified as muscle aponeurotic fibromatosis were selected.
  • Samples were grouped by tumor location in: head and neck, extremity and abdominal/trunk; type of resection of the primary tumor (complete resection with adequate margins, marginal resection and resection with inadequate margins); type of treatment (exclusive surgery, surgery followed by radiation therapy and surgery followed by tamoxifen or cyclooxygenase inhibitor).
  • Tumor location (p = 0.006) and type of resection (p = 0.001) were predictive of local relapse in the univariate analysis.
  • Head and neck and extremities lesions showed higher recurrence rates compared to abdominal/trunk lesions.
  • In conclusion, although this is a retrospective study, the results presented can contribute to better understanding of the mechanisms under desmoid tumor development and can propose tamoxifen as a therapeutic option to be tested in prospective trials.
  • [MeSH-major] Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / metabolism. Fibromatosis, Aggressive / metabolism. Fibromatosis, Aggressive / therapy. Proto-Oncogene Proteins c-kit / metabolism. Receptors, Progesterone / metabolism

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  • (PMID = 20305341.001).
  • [ISSN] 1881-7823
  • [Journal-full-title] Bioscience trends
  • [ISO-abbreviation] Biosci Trends
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Receptors, Progesterone; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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39. Bhosale PR, Patnana M, Viswanathan C, Szklaruk J: The inguinal canal: anatomy and imaging features of common and uncommon masses. Radiographics; 2008 May-Jun;28(3):819-35; quiz 913
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  • Benign causes of masses in the IC include spermatic cord lipoma, hematoma, abscess, neurofibroma, varicocele, desmoid tumor, air, bowel contrast material, hydrocele, and prostheses.
  • Metastases to the IC can occur from alveolar rhabdomyosarcoma, monophasic sarcoma, prostate cancer, Wilms tumor, carcinoid tumor, melanoma, or pancreatic cancer.
  • In patients with a known malignancy and peritoneal carcinomatosis, the diagnosis of metastases can be suggested when a mass is detected in the IC.
  • When peritoneal disease is not evident, a mass in the IC is indicative of stage IV disease and may significantly alter clinical and surgical treatment of the patient.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Inguinal Canal / pathology. Inguinal Canal / radiography. Peritoneal Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Rare Diseases / diagnosis

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  • [Copyright] Copyright RSNA, 2008.
  • (PMID = 18480486.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 88
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40. Al-Otaibi ML, Turcotte RE, Hings I, Beaudet J, Isler M, Nahal A, Wong C: Low-dose chemotherapy for extra-abdominal desmoid tumor. Saudi Med J; 2008 Dec;29(12):1730-4
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  • [Title] Low-dose chemotherapy for extra-abdominal desmoid tumor.
  • OBJECTIVE: To assess the outcome of patients with extra-abdominal desmoid tumor treated with low dose chemotherapy (methotrexate and vinblastine) both for tumor response and treatment related toxicity.
  • METHODS: We retrospectively reviewed the outcome of 12 patients who underwent low dose chemotherapy for extra abdominal desmoid of different locations.
  • We evaluated the patients for their compliance, tumor response, complications of treatment, and impact of treatment on symptoms.
  • RESULTS: Disease related morbidity included pain in 7 patients, functional limitation in 7 and cosmetic defects in 3.
  • The mean tumor size was 11 cm (3-20 cm).

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  • (PMID = 19082222.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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41. Burnside KL, Ryan JT, Bielefeldt-Ohmann H, Gregory Bruce A, Thouless ME, Tsai CC, Rose TM: RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells. Virology; 2006 Oct 10;354(1):103-15
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  • [Title] RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells.
  • Retroperitoneal fibromatosis herpesvirus (RFHV), the macaque homolog of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV), was first identified in retroperitoneal fibromatosis (RF) tumor lesions of macaques with simian AIDS.
  • Immunohistochemical and immunofluorescence analysis revealed that RFHVMn LANA is a nuclear antigen which is highly expressed in RF spindloid tumor cells.
  • [MeSH-major] Antigens, Viral / genetics. Fibroma / virology. Nuclear Proteins / genetics. Open Reading Frames. Retroperitoneal Neoplasms / virology. Rhadinovirus / genetics
  • [MeSH-minor] Amino Acid Sequence. Animals. Antibodies, Monoclonal. Cell Nucleus / chemistry. Cloning, Molecular. DNA, Viral / chemistry. DNA, Viral / genetics. Immunohistochemistry. Macaca nemestrina. Microscopy, Fluorescence. Molecular Sequence Data. Protein Structure, Secondary. Protein Structure, Tertiary. Sequence Analysis, DNA. Sequence Homology, Amino Acid. Tumor Cells, Cultured

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  • (PMID = 16879850.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE07023; United States / NIAID NIH HHS / AI / K02 AI49275; United States / NCRR NIH HHS / RR / RR13154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Viral; 0 / DNA, Viral; 0 / Nuclear Proteins; 0 / latency-associated nuclear antigen
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42. Pérez García FJ, Pinto Blazquez J, Rodríguez Martínez JJ, Gutiérrez García R, Jorge Barreiro JI, Velasco Alonso J: [Mesenteric desmoid tumor mimicking a testicular cancer recurrence]. Arch Esp Urol; 2007 Jul-Aug;60(6):703-6
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  • [Title] [Mesenteric desmoid tumor mimicking a testicular cancer recurrence].
  • [Transliterated title] Tumor desmoide mesentérico simulando una recidiva de cáncer testicular.
  • OBJECTIVE: Report of one case of desmoid tumor in a patient who had been treated of a testicular seminoma 26 months before, with excision of a retroperitoneal mass and chemotherapy.
  • On followup he presented with a mesenteric abdominal mass which was clinically labeleled as a recurrence of the seminoma.
  • RESULTS: Histologically it was reported as a mesenteric desmoid tumor.
  • Differential diagnosis with gastrointestinal stromal tumor was performed with immunohistochemical studies.
  • CONCLUSIONS: Desmoid tumor is rare.
  • There are few cases reported in patients with history of previous testicular tumor.
  • It should be included in the differential diagnosis of testicular tumor recurrences.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Mesentery. Peritoneal Neoplasms / diagnosis. Seminoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17847750.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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43. Prat A, Peralta S, Cuéllar H, Ocaña A: Hepatic pneumatosis as a complication of an abdominal desmoid tumor. J Clin Oncol; 2007 Mar 1;25(7):897-8
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  • [Title] Hepatic pneumatosis as a complication of an abdominal desmoid tumor.
  • [MeSH-major] Fibromatosis, Abdominal / complications. Liver Diseases / etiology
  • [MeSH-minor] Adult. Gases. Humans. Male. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 17327611.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gases
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44. Matono H, Oda Y, Nakamori M, Tamiya S, Yamamoto H, Yokoyama R, Saito T, Iwamoto Y, Tsuneyoshi M: Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors. Hum Pathol; 2008 Dec;39(12):1802-8
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  • [Title] Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors.
  • Desmoid tumors (desmoid-type fibromatoses) are locally aggressive soft tissue tumors associated with the Wnt/beta-catenin signaling pathway (APC-beta-catenin-Tcf pathway).
  • Matrix metalloproteinase-7, which is one of the target genes of the Wnt/beta-catenin signaling pathway, has been reported to play an important role in tumor progression.
  • We examined the immunohistochemical expression of beta-catenin and matrix metalloproteinase-7 in 72 samples (63 primary and 9 recurrent samples, 63 patients) of sporadic desmoid tumors without familial adenomatous polyposis, and the genetic alteration of the beta-catenin gene in 33 frozen materials (22 primary and 11 recurrent samples, 22 patients).
  • Immunohistochemically, there was a statistically significant correlation between widespread nuclear expression of beta-catenin and overexpression of matrix metalloproteinase-7 (P < .01 in extra-abdominal desmoid, Fisher test).
  • Our results suggest that the matrix metalloproteinase-7 gene may be up-regulated by mutated or continuously elevated beta-catenin protein and that the matrix metalloproteinase-7 gene may also be targeted in the Wnt/beta-catenin signaling pathway in sporadic desmoid tumors.
  • [MeSH-major] Fibromatosis, Aggressive / metabolism. Gene Expression Regulation, Neoplastic. Matrix Metalloproteinase 7 / metabolism. Soft Tissue Neoplasms / metabolism. beta Catenin / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Cell Nucleus / metabolism. Child. Child, Preschool. Female. Humans. Infant. Male. Middle Aged. Mutation, Missense. RNA, Messenger / metabolism. RNA, Neoplasm / analysis. Reverse Transcriptase Polymerase Chain Reaction. Young Adult

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  • (PMID = 18715618.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / RNA, Messenger; 0 / RNA, Neoplasm; 0 / beta Catenin; EC 3.4.24.23 / MMP7 protein, human; EC 3.4.24.23 / Matrix Metalloproteinase 7
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45. Liao CM, Chang WC, Ko KH, Kao HW, Cheng MF, Huang GS, Wu CJ: Desmoid tumor arising in the site of previous surgery in the left lower quadrant of the abdomen. South Med J; 2010 Feb;103(2):162-4
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  • [Title] Desmoid tumor arising in the site of previous surgery in the left lower quadrant of the abdomen.
  • A desmoid tumor is a fibroblastic proliferation arising in musculoaponeurotic structures.
  • A 79-year-old woman who developed a desmoid tumor in the left lower abdomen after surgical resection of an abdominal lipoma seven years previously is presented.
  • Preoperative computed tomography showed a large left lower abdominal mass.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 20175252.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. de Ferro SM, Suspiro A, Fidalgo P, Lage P, Rodrigues P, Fragoso S, Vitoriano I, Baltazar C, Albuquerque C, Bettencourt A, Leitão CN: Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case. Dis Colon Rectum; 2009 Apr;52(4):742-5
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  • [Title] Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case.
  • MYH-associated polyposis is an inherited autosomal recessive disease, linked to biallelic germline MYH mutations, which predisposes to the development of multiple colorectal adenomas and cancer.
  • When he was 39 years old, he developed three synchronous jejunal adenocarcinomas and a mesenteric desmoid tumor.
  • Similar to patients with familial adenomatous polyposis, desmoid tumors also may be part of the clinical spectrum of MYH-associated polyposis and may prove to be a significant clinical problem in patients submitted to prophylactic colectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. Fibromatosis, Aggressive / genetics. Jejunal Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Peritoneal Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adult. DNA Glycosylases / genetics. Duodenal Neoplasms / genetics. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Intestinal Neoplasms / genetics. Intestinal Obstruction / etiology. Liver Neoplasms / secondary. Male. Mesentery. Mutation. Phenotype. Syndrome


47. Umbach JL, Strelow LI, Wong SW, Cullen BR: Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques. Virology; 2010 Sep 30;405(2):592-9
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  • Using deep sequencing, we analyzed the pattern of small RNA expression in vivo using latently RRV-infected B-cell lymphoma and retroperitoneal fibromatosis tissues.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • [ISSN] 1096-0341
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA132638; United States / NIAID NIH HHS / AI / R01-AI067968; United States / NIAID NIH HHS / AI / R01 AI067968; United States / NCI NIH HHS / CA / CA075922-14; United States / NCRR NIH HHS / RR / P51 RR000163; United States / NCI NIH HHS / CA / R01 CA132638-03; United States / NCI NIH HHS / CA / R01-CA075922; United States / NCI NIH HHS / CA / R01 CA075922-14; United States / NCI NIH HHS / CA / T32 CA009111; United States / NCRR NIH HHS / RR / K01 RR000163; United States / NCI NIH HHS / CA / T32-CA009111; United States / NCRR NIH HHS / RR / RR000163; United States / NCI NIH HHS / CA / R01 CA075922; United States / NCI NIH HHS / CA / CA132638-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Viral
  • [Other-IDs] NLM/ NIHMS219827; NLM/ PMC2923253
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48. Orzechowska BU, Manoharan M, Sprague J, Estep RD, Axthelm MK, Wong SW: Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD). J Med Primatol; 2009 Oct;38 Suppl 1:2-7
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  • [Title] Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD).
  • BACKGROUND: Rhesus macaques (RM) co-infected with simian immunodeficiency virus (SIV) and rhesus macaque rhadinovirus (RRV) develop abnormal cellular proliferations characterized as extra-nodal lymphoma and retroperitoneal fibromatosis (RF).
  • CONCLUSIONS: Our data support the idea that vIL-6 may be critical to the development and progression of lymphoproliferative disorder in RRV/SIV-infected RM.

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  • (PMID = 19863672.001).
  • [ISSN] 1600-0684
  • [Journal-full-title] Journal of medical primatology
  • [ISO-abbreviation] J. Med. Primatol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA132638; United States / NCI NIH HHS / CA / R01 CA075922-13; United States / NCRR NIH HHS / RR / P51 RR000163; United States / NCI NIH HHS / CA / CA075922-13; United States / NCI NIH HHS / CA / R01 CA132638-03; United States / NCRR NIH HHS / RR / RR00163; United States / NCI NIH HHS / CA / CA 75922; United States / NCRR NIH HHS / RR / K01 RR000163; United States / NCI NIH HHS / CA / R01 CA075922; United States / NCI NIH HHS / CA / CA132638-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Interleukin-6
  • [Other-IDs] NLM/ NIHMS262273; NLM/ PMC3022225
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49. González MA, Menéndez R, Ayala JM, Herrero M, Cuesta J, Domínguez A, Martínez M, Graña JL, Pozo F: [Intra-abdominal desmoid tumor]. Cir Esp; 2005 Jun;77(6):362-4
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  • [Title] [Intra-abdominal desmoid tumor].
  • [Transliterated title] Tumor desmoide intraabdominal.
  • Aggressive fibromatosis (desmoid tumor) are rare connective tissue tumors that occur sporadically or in association with familial adenomatous polyposis.
  • Biopsy is required to establish the diagnosis.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16420952.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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50. Mazzocchi M, Onesti MG, Di Ronza S, Scuderi N: Breast desmoid tumor after augmentation mammoplasty: two case reports. Acta Chir Plast; 2009;51(3-4):73-8
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  • [Title] Breast desmoid tumor after augmentation mammoplasty: two case reports.
  • Desmoid tumor of the breast is a rare fibroblastic disease, a slow-growing and histologically benign lesion that accounts for 0.2% of all breast tumors.
  • We describe two cases of breast desmoid tumor after breast augmentation.
  • The results of this histological examination suggested an extra-abdominal desmoid tumor.
  • [MeSH-major] Breast Implantation. Breast Neoplasms / surgery. Fibromatosis, Aggressive / surgery. Postoperative Complications / surgery

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  • (PMID = 20514891.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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51. Kadoch V, Bodin F, Himy S, Bollecker V, Wilk A, Bruant-Rodier C: Latissimus dorsi free flap for reconstruction of extensive full-thickness abdominal wall defect. A case of desmoid tumor. J Visc Surg; 2010 Apr;147(2):e45-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Latissimus dorsi free flap for reconstruction of extensive full-thickness abdominal wall defect. A case of desmoid tumor.
  • Desmoid tumor is a rare, benign fibroblastic tumor that is characterized by highly aggressive local invasiveness.
  • The authors report the case of a 35-year-old male who presented with a 20 cm para-umbilical tumor invading the right rectus abdominis muscle.
  • This required a wide excision of the abdominal wall.

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
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  • (PMID = 20692637.001).
  • [ISSN] 1878-7886
  • [Journal-full-title] Journal of visceral surgery
  • [ISO-abbreviation] J Visc Surg
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY015928-01; United States / NCRR NIH HHS / RR / RR001315-255511; United States / NEI NIH HHS / EY / F31 EY015928-01; United States / NCRR NIH HHS / RR / P41 RR001315-255511
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Other-IDs] NLM/ NIHMS218152; NLM/ PMC2924994
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52. Fakhar S, Qazi MP, Saeed G, Ashraf M, Tariq N: Successful surgical removal of a huge pelvic desmoid tumor. Taiwan J Obstet Gynecol; 2010 Sep;49(3):361-3
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  • [Title] Successful surgical removal of a huge pelvic desmoid tumor.
  • [MeSH-major] Fibromatosis, Abdominal / surgery. Fibromatosis, Aggressive / surgery. Radiography, Abdominal. Severity of Illness Index. Tomography, X-Ray Computed
  • [MeSH-minor] Abdomen. Adult. Female. Humans

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  • (PMID = 21056325.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] China
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53. Stalinska L, Turant M, Tosik D, Sygut J, Kulig A, Kopczynski J, Dziki A, Ferenc T: Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor). Histol Histopathol; 2009 03;24(3):299-308
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  • [Title] Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor).
  • Aggressive fibromatosis (desmoid tumor) is a mesenchymal lesion originating from fascial, aponeurotic and muscular connective tissue.
  • In this study we analyzed the cell cycle regulation proteins: pRb, p16, and proliferating antigens: Ki-67, PCNA, MCM5 with immunohistochemical method in archival material derived from 27 extra-abdominal (E-AD), 18 abdominal (AD) and 5 intra-abdominal (I-AD) cases of desmoid tumor.
  • None of the examined cases (n=50) of aggressive fibromatosis was pRb-immunonegative.
  • The noted levels of pRb and p16 expression in desmoid cells reflect their function in cell cycle regulation.
  • Probably the unsettled cell cycle progression, especially in G1 phase, is not the cause of aggressive fibromatosis pathogenesis.
  • [MeSH-major] Cell Cycle Proteins / analysis. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Fibromatosis, Abdominal / metabolism. Ki-67 Antigen / analysis. Proliferating Cell Nuclear Antigen / analysis. Retinoblastoma Protein / analysis


54. Toiyama Y, Konishi N, Inoue Y, Yoshiyama S, Araki T, Miki C, Kusunoki M: Successful treatment of ileal pouch desmoids using multimodal chemotherapy with low-dose vinblastine and methotrexate in a patient with familial adenomatous polyposis. Clin J Gastroenterol; 2009 Jun;2(3):170-174
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a case of multiple desmoid tumors (DT) that developed in an ileal J pouch, which were successfully treated by low-dose combination chemotherapy using vinblastine (VBL) and methotrexate (MTX).
  • DT involving both the abdominal wall and the ileal pouch developed after total proctocolectomy with ileoanal anastomosis for familial adenomatous polyposis in a 26-year-old female who was treated in an outpatient unit with low-dose VBL and MTX biweekly for 12 months.
  • The treatment response was assessed at routine intervals by physical examination and abdominal computer tomography (CT) imaging.
  • Abdominal CT imaging revealed a decrease in tumor size, and the plasma D-dimer levels decreased in association with tumor regression.
  • This case report shows the efficacy of a low-dose combination chemotherapeutic regimen of VBL and MTX for the treatment of ileoanal pouch mesenteric DT in an outpatient setting.
  • In addition, plasma D-dimers may be a marker for desmoid tumor treatment efficacy.

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  • (PMID = 26192289.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Chemotherapy / D-dimer / Desmoid / FAP / Ileal pouch
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55. Okuno S: The enigma of desmoid tumors. Curr Treat Options Oncol; 2006 Nov;7(6):438-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The enigma of desmoid tumors.
  • Desmoid tumors (aggressive fibromatosis) are rare neoplastic tumors that may occur sporadically or in association with familial adenomatous polyposis (FAP).
  • A distinction is often made between desmoids in patients with FAP and those in patients without FAP, but clinically these tumors are treated the same; the only difference is the preferential intra-abdominal location of FAP desmoids.
  • The goal of desmoid treatment is local control.
  • Patients with symptomatic, progressive disease who can tolerate chemotherapy should be presented with the option of low-dose or standard antisarcoma chemotherapy.
  • The treatment of desmoid tumors remains an enigma.
  • Further clinical trials are needed to help the clinician navigate his or her way through the morass of desmoid tumor therapies.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Abdominal / drug therapy

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  • (PMID = 17032556.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 094ZI81Y45 / Tamoxifen; 9008-11-1 / Interferons
  • [Number-of-references] 22
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56. Singh N, Sharma R, Dorman SA, Dy VC: An unusual presentation of desmoid tumor in the ileum. Am Surg; 2006 Sep;72(9):821-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual presentation of desmoid tumor in the ileum.
  • Desmoid tumors are nonencapsulated, locally invasive tumors of fibrous origin.
  • Intra-abdominal desmoids are commonly found in the mesentery.
  • We present the report of a case in which a sporadic desmoid tumor originated from the wall of the ileum.
  • Of all the options described, surgery with tumor-free margins has been defined as the best treatment modality.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Ileal Neoplasms / diagnosis

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  • (PMID = 16986393.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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57. Batori M, Chatelou E, Mariotta G, Sportelli G, Straniero A, Casella G, Casella MC: Giant mesenteric fibromatosis. Eur Rev Med Pharmacol Sci; 2005 Jul-Aug;9(4):223-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mesenteric fibromatosis.
  • Mesenteric fibromatosis is a proliferative fibroblastic neoplasia of the small intestine mesentery which may occur as a unique or multiple formation.
  • Mesenteric fibromatosis represents the 8% of all desmoid neoplasm.
  • Giant mesenteric fibromatosis is uncommon by itself (2-4 case/milion/year).
  • Since the rarity of this tumor and the difficulties in diagnostic and therapeutic ambit, we believe it justified to describe a case of giant mesenteric fibromatosis which came to our observation.

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  • (PMID = 16128042.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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58. Bielefeldt-Ohmann H, Barouch DH, Bakke AM, Bruce AG, Durning M, Grant R, Letvin NL, Ryan JT, Schmidt A, Thouless ME, Rose TM: Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta). Vet Pathol; 2005 May;42(3):391-6
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  • Polymerase chain reaction analysis of DNA from tumor and spleen tissue revealed abundant, preferential presence of retroperitoneal fibromatosis herpesvirus, the macaque homologue of the Kaposi sarcoma-associated herpesvirus (human herpesvirus-8), in the tumors.
  • This was corroborated by demonstration of viral latent nuclear antigen-1 in the nuclei of a majority of the spindeloid tumor cells.
  • Low levels of an additional macaque herpesvirus, rhesus rhadinovirus, were also detected in the spleen and tumor tissues.

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  • (PMID = 15872392.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / K02-AI49275; United States / NIAID NIH HHS / AI / N01-AI-15431; United States / NCRR NIH HHS / RR / P51RR00166; United States / NCRR NIH HHS / RR / R01-RR13154
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / DNA Primers; 0 / Vimentin
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59. Levy AD, Rimola J, Mehrotra AK, Sobin LH: From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation. Radiographics; 2006 Jan-Feb;26(1):245-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mesenteric fibromatosis, sclerosing mesenteritis, inflammatory pseudotumor, and extrapleural solitary fibrous tumor constitute a loosely associated group of benign fibrous tumors and tumorlike lesions of the mesentery.
  • Mesenteric fibromatosis is a locally aggressive, benign proliferative process that may occur sporadically or in association with familial adenomatous polyposis.
  • It most frequently manifests as a focal mesenteric mass and may simulate lymphoma, metastatic disease, or a soft-tissue sarcoma.
  • Sclerosing mesenteritis is a rare idiopathic disorder that most commonly produces a stellate mass within the mesentery and should be differentiated from metastatic disease, specifically metastatic carcinoid, because it frequently responds to conservative or medical management.
  • Inflammatory pseudotumor (inflammatory myofibroblastic tumor) is a benign, chronic inflammatory disorder of unknown cause that manifests as a solid mesenteric mass, indistinguishable from malignancy.
  • Extrapleural solitary fibrous tumor is a tumor of submesothelial origin that is identical to the solitary fibrous tumor of the pleura.
  • When located in the mesentery or peritoneal cavity, extrapleural solitary fibrous tumor has an imaging pattern that must be differentiated from metastatic disease, soft-tissue sarcomas, and other benign and malignant neoplasms of the mesentery and peritoneum.
  • Knowledge of this group of benign fibrous tumors and tumorlike lesions of the mesentery is important in the preoperative evaluation of a mesenteric mass.
  • [MeSH-major] Mesentery. Peritoneal Diseases / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Female. Fibroma / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Panniculitis, Peritoneal / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16418255.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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60. Ishizuka M, Hatori M, Dohi O, Suzuki T, Miki Y, Tazawa C, Sasano H, Kokubun S: Expression profiles of sex steroid receptors in desmoid tumors. Tohoku J Exp Med; 2006 Nov;210(3):189-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression profiles of sex steroid receptors in desmoid tumors.
  • Desmoid tumors are benign fibrous neoplasms which arise from the fibrous tissue of intra- and extra- abdominal sites, but their clinical management is sometimes difficult because of extensive infiltration into the surrounding tissues.
  • Desmoid tumors commonly occur in women, especially after childbirth.
  • Recently, both clinical and experimental findings indicate the possible roles of sex steroids in the development and progression of desmoid tumors but detailed information is still ambiguous.
  • In this study, we first examined immunoreactivity of sex steroid receptors in desmoid tumors (27 cases) by immunohistochemistry and compared the findings with those in reactive self-limiting lesions associated with fibrosis (8 cases).
  • Estrogen receptor (ER) alpha and ERbeta immunoreactivities were detected in 7.4% (2/27) and 7.4% (2/27) of desmoid tumors, respectively.
  • One desmoid tumor expressed both ERalpha and ERbeta.
  • Sex steroid receptor mRNAs was further examined by reverse transcription and polymerase chain reaction (RT-PCR) analysis using fresh frozen tissues, demonstrating the expression of PR (PR-A and/or PR-B) and AR mRNAs in eight desmoid tumors examined and all cases of reactive fibrosis.
  • These results indicate that sex steroid hormones might play an important role in the pathogenesis of desmoid tumors and could lead to the introduction of novel hormone therapeutic approaches in managing patients with recurrent desmoid tumors.
  • [MeSH-major] Fibromatosis, Aggressive / metabolism. Gene Expression Regulation, Neoplastic. Neoplasms / metabolism. Receptors, Steroid / metabolism

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  • (PMID = 17077595.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Receptors, Progesterone; 0 / Receptors, Steroid
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61. Durkin AJ, Korkolis DP, Al-Saif O, Zervos EE: Full-term gestation and transvaginal delivery after wide resection of an abdominal desmoid tumor during pregnancy. J Surg Oncol; 2005 Feb 1;89(2):86-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Full-term gestation and transvaginal delivery after wide resection of an abdominal desmoid tumor during pregnancy.
  • A 29-year-old female was diagnosed with a symptomatic, extra-abdominal desmoid tumor during the first trimester of pregnancy.
  • Preoperative diagnosis was confirmed by core-needle biopsy of the lesion.
  • At 20-weeks gestation, wide local resection of the tumor with disease-free margins, as well as abdominal wall reconstruction with polytetrafluoroethylene (PTFE) mesh was successfully undertaken.
  • Histological examination of the tumor ex vivo confirmed that the lesion was a desmoid tumor consisting of spindle cells with dense infiltrating collagenous fibers.
  • This case illustrates the probable contribution of estrogens towards desmoid tumor development, the durability of abdominal wall reconstruction when subjected to the extraordinary strain of both a gravid uterus and labor, as well as the safety and efficacy of aggressive surgical therapy during pregnancy.
  • [MeSH-major] Abdominal Wall / surgery. Delivery, Obstetric. Fibromatosis, Abdominal / surgery. Pregnancy Complications, Neoplastic / surgery


62. Yu YH, Son BK, Jun DW, Kim SH, Jo YJ, Park YS, Hong BW, Joo JE: [A case of desmoid tumor presenting as intra-abdominal abscess]. Korean J Gastroenterol; 2009 May;53(5):315-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of desmoid tumor presenting as intra-abdominal abscess].
  • Desmoid tumor is a rare benign tumor derived from fibrous sheath or musculoaponeurotic structure.
  • The tumor is benign histologically but considered as malignant clinically because it has high propensity on infiltrative growth with local invasion and tendency to recurrence after local excision.
  • Especially, when this tumor happens to be in the intra-abdomen, the prognosis is worse because it can cause intestinal obstruction, ureter obstruction and, fistula formation.
  • It also can invade major vessels in abdomen.
  • This tumor occurs more frequently in patients with familial adenomatous polyposis (FAP), in post-partume women, and at old surgical incision site.
  • We report a rare case of the young male patient who presented with an acute abdomen and underwent laparotomy and was found to have an intra-abdominal desmoid tumor with abscess formation.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Abscess / diagnosis. Adult. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19458469.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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63. Cholongitas E, Koulenti D, Panetsos G, Kafiri G, Tzirakis E, Thalasinou P, Papatheodoridis GV: Desmoid tumor presenting as intra-abdominal abscess. Dig Dis Sci; 2006 Jan;51(1):68-9
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  • [Title] Desmoid tumor presenting as intra-abdominal abscess.
  • [MeSH-major] Abdominal Abscess / diagnosis. Abdominal Neoplasms / diagnostic imaging. Fibromatosis, Aggressive / diagnostic imaging
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Laparotomy. Tomography, X-Ray Computed

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64. Westmoreland SV, Mansfield KG: Comparative pathobiology of Kaposi sarcoma-associated herpesvirus and related primate rhadinoviruses. Comp Med; 2008 Feb;58(1):31-42
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  • Recently several new species-specific rhadinoviruses of Old World primates have been described, including retroperitoneal fibromatosis herpesvirus and rhesus rhadinovirus (Cercopithecine herpesvirus 17).
  • This review examines the comparative pathobiology of KSHV, discusses the role of macaque rhadinoviruses as models of human disease, and outlines the derivation of specific pathogen-free animals.

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  • (PMID = 19793454.001).
  • [ISSN] 1532-0820
  • [Journal-full-title] Comparative medicine
  • [ISO-abbreviation] Comp. Med.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / RR16020; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / U42 RR016020
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon Regulatory Factor-1; 0 / Interferon Regulatory Factors; 0 / MicroRNAs; 0 / RNA, Viral; 0 / Viral Proteins; 0 / interferon regulatory factor-4
  • [Number-of-references] 93
  • [Other-IDs] NLM/ PMC2703163
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65. Ioannou M, Demertzis N, Iakovidou I, Kottakis S: The role of imatinib mesylate in adjuvant therapy of extra-abdominal desmoid tumors. Anticancer Res; 2007 Mar-Apr;27(2):1143-7
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  • [Title] The role of imatinib mesylate in adjuvant therapy of extra-abdominal desmoid tumors.
  • BACKGROUND: Extra-abdominal desmoid tumors are rare neoplasms with variable biological behavior.
  • The purpose of this study was to determine the possible presence of tyrosine-kinase receptors in extra-abdominal desmoid tumors as a marker for imatinib mesylate therapy.
  • PATIENTS AND METHODS: From 1999 to 2004, immunohistochemical methods were carried-out in 14 patients with histologically confirmed extra-abdominal desmoid tumors to determine c-KIT positivity (existence of tyrosine-kinase receptors and PDGFRA and PDGFRB).
  • RESULTS: All desmoid tumors were c-KIT negative, which demonstrates absence of tyrosine-kinase receptors.
  • CONCLUSION: The histological c-KIT markup is an easy and reliable method that can detect whether a desmoid tumor is sensitive to additional treatment with a tyrosine-kinase receptor inhibitor.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Fibromatosis, Aggressive / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 17465254.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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66. Bruce AG, Bakke AM, Bielefeldt-Ohmann H, Ryan JT, Thouless ME, Tsai CC, Rose TM: High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells. J Gen Virol; 2006 Dec;87(Pt 12):3529-38
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  • [Title] High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells.
  • In macaques, the RV1 lineage is represented by retroperitoneal fibromatosis (RF) herpesvirus (RFHV), the homologue of KSHV, whilst the RV2 lineage is represented by rhesus rhadinovirus (RRV), a more distantly related virus.
  • The RV1 loads were 220- to 4300-fold higher in RF tumours than in spleen, showing a strong tumour association (mean loads of 1 800 000 vs 2900 copies per 10(6) cells in tumours and spleen, respectively).
  • Immunostaining with antibodies reactive against RFHV ORF73 latency-associated nuclear antigen (LANA) showed intense nuclear staining of the spindleoid RF tumour cells.
  • Correlation of viral load and the number of LANA-positive cells indicated that RF tumour cells contained multiple copies of the RFHV genome per cell.
  • [MeSH-major] Antigens, Viral / biosynthesis. DNA, Viral / analysis. Herpesviridae Infections / virology. Nuclear Proteins / biosynthesis. Retroperitoneal Neoplasms / virology. Rhadinovirus / physiology. Simian Acquired Immunodeficiency Syndrome / complications. Tumor Virus Infections / virology
  • [MeSH-minor] Animals. Disease Models, Animal. Immunohistochemistry. Macaca mulatta. Macaca nemestrina. Polymerase Chain Reaction / methods. Spleen / virology. Statistics as Topic

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  • (PMID = 17098967.001).
  • [ISSN] 0022-1317
  • [Journal-full-title] The Journal of general virology
  • [ISO-abbreviation] J. Gen. Virol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / K02 AI49275; United States / NCRR NIH HHS / RR / RR00166; United States / NCRR NIH HHS / RR / RR13154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / DNA, Viral; 0 / Nuclear Proteins; 0 / latency-associated nuclear antigen
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67. Bhama PK, Chugh R, Baker LH, Doherty GM: Gardner's syndrome in a 40-year-old woman: successful treatment of locally aggressive desmoid tumors with cytotoxic chemotherapy. World J Surg Oncol; 2006;4:96
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  • [Title] Gardner's syndrome in a 40-year-old woman: successful treatment of locally aggressive desmoid tumors with cytotoxic chemotherapy.
  • BACKGROUND: Desmoid tumors that present as a part of Gardener's syndrome can present very difficult management problems.
  • CASE PRESENTATION: We report a case of intra-abdominal desmoid tumor causing distal small bowel obstruction that complicated the management of a more proximal enterocutaneous fistula from the jejunum.
  • After failure of more conventional management options including imatinib, the patient's disease responded to doxorubicin and ifosfamide.
  • CONCLUSION: Systemic cytotoxic therapy with doxorubicin and ifosfamide can be useful for patients with complications from intra-abdominal desmoid tumor.

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  • (PMID = 17173703.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1716167
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68. Lund H, Ekvall BF: [Mesenteric fibromatosis]. Ugeskr Laeger; 2009 Nov 23;171(48):3539-40
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  • [Title] [Mesenteric fibromatosis].
  • [Transliterated title] Mesenteriel fibromatose.
  • Mesenterial fibromatosis is a benign proliferating neoplasia that originates from the mesenterium or retroperitoneum.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Intestine, Small / pathology. Mesentery. Neoplasm Recurrence, Local

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  • (PMID = 19944057.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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69. Privette A, Fenton SJ, Mone MC, Kennedy AM, Nelson EW: Desmoid tumor: a case of mistaken identity. Breast J; 2005 Jan-Feb;11(1):60-4
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  • [Title] Desmoid tumor: a case of mistaken identity.
  • Desmoid tumors are rare tumors accounting for only 0.03% of all neoplasms.
  • Mainly occurring in the fourth and fifth decades of life, these tumors originate in musculoaponeurotic tissues of the limbs, neck, trunk, abdominal wall, and mesentery.
  • We present a rare case of a chest wall desmoid tumor that was mistaken for breast cancer on both physical examination and mammography, which highlights the unique risk these tumors present for confusion with other malignant processes.
  • Although past literature contains numerous reports of other misdiagnoses, this case is unique in reporting the potential for misdiagnosis between chest wall desmoid tumors and breast cancer.
  • In cases where suspicious breast findings do not correlate to usual diagnostic measures, such as fine-needle aspiration or core needle biopsy, the possibility of another pathology such as a chest wall desmoid tumor mimicking breast cancer should be considered in the differential diagnosis.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Thoracic Neoplasms / diagnosis. Thoracic Wall
  • [MeSH-minor] Aged. Biopsy, Needle. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms / surgery. Breast Neoplasms / ultrasonography. Diagnosis, Differential. Female. Humans. Mammography. Mastectomy. Tomography, X-Ray Computed

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  • (PMID = 15647081.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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70. Ayhan S, Temız P, Kurt K: Mesenteric fibromatosis: a case report. Turk J Gastroenterol; 2010 Jun;21(2):193-5
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  • [Title] Mesenteric fibromatosis: a case report.

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  • (PMID = 20872340.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Turkey
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71. Jalini L, Hemming D, Bhattacharya V: Intraabdominal desmoid tumour presenting with perforation. Surgeon; 2006 Apr;4(2):114-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraabdominal desmoid tumour presenting with perforation.
  • We present a rare case of a desmoid tumour presenting with perforation of the small bowel.
  • Although desmoid is classified pathologically as a benign tumour, its infiltrative nature leads to a locally aggressive mass, which can invade surrounding structures and organs making surgical resection difficult.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Intestinal Perforation / etiology. Intestine, Small. Mesentery. Peritoneal Neoplasms / pathology

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  • (PMID = 16623170.001).
  • [ISSN] 1479-666X
  • [Journal-full-title] The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
  • [ISO-abbreviation] Surgeon
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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72. Coco DP, Hirsch MS, Hornick JL: Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol; 2009 Dec;33(12):1795-801
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  • The purpose of this study was to determine whether immunostaining for smoothelin could help distinguish smooth muscle neoplasms from their morphologic mimics, particularly KIT-negative gastrointestinal stromal tumors (GISTs), desmin-positive GISTs, and desmoid fibromatosis.
  • A total of 150 mesenchymal neoplasms of the GI tract, abdominal cavity, and retroperitoneum were retrieved from consult and surgical pathology archives, including 54 GISTs (8 KIT-negative; 13 desmin-positive), 17 GI leiomyosarcomas (LMS), 11 GI mural leiomyomas, 13 leiomyomas of the muscularis mucosae, 12 gastric schwannomas, 15 inflammatory myofibroblastic tumors, 9 cases of mesenteric desmoid fibromatosis, 10 dedifferentiated liposarcomas, and 9 malignant peripheral nerve sheath tumors.
  • None of the GISTs, desmoid tumors, inflammatory myofibroblastic tumors, schwannomas, dedifferentiated liposarcomas, or malignant peripheral nerve sheath tumors showed cytoplasmic reactivity for smoothelin.
  • Nuclear expression of smoothelin was not detected in any of the other tumor types examined.
  • [MeSH-major] Biomarkers, Tumor / analysis. Cytoskeletal Proteins / analysis. Gastrointestinal Neoplasms / chemistry. Muscle Proteins / analysis. Smooth Muscle Tumor / chemistry
  • [MeSH-minor] Cell Differentiation. Cell Nucleus / chemistry. Cytoplasm / chemistry. Desmin / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Neoplasm Staging. Predictive Value of Tests. Proto-Oncogene Proteins c-kit / analysis. Sensitivity and Specificity

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  • (PMID = 19950405.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cytoskeletal Proteins; 0 / Desmin; 0 / Muscle Proteins; 0 / SMTN protein, human; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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73. Shah M, Azam B: Case report of an intra-abdominal desmoid tumour presenting with bowel perforation. Mcgill J Med; 2007 Jul;10(2):90-2
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  • [Title] Case report of an intra-abdominal desmoid tumour presenting with bowel perforation.
  • Desmoid tumours are benign tumours originating from the musculoaponeurotic structures of the body.
  • Here we present a case report of a young gentleman who presented with an acute surgical abdomen and subsequently underwent a laparotomy and was found to have an inflammatory mass.
  • Histological analysis of this mass revealed mesenteric fibromatosis (desmoid tumour).
  • It is rare for mesenteric fibromatosis to present with intestinal perforation and only one case been reported in the literature thus far (1).

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  • [Cites] Front Radiat Ther Oncol. 2001;35:107-19 [11351941.001]
  • [Cites] Arch Pathol. 1961 Feb;71:214-21 [13706852.001]
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  • (PMID = 18523540.001).
  • [ISSN] 1201-026X
  • [Journal-full-title] McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students
  • [ISO-abbreviation] Mcgill J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2323473
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74. Koh PK, Loi C, Cao X, Cheah PY, Ho KS, Ooi BS, Tang CL, Eu KW: Mesenteric desmoid tumors in Singapore familial adenomatous polyposis patients: clinical course and genetic profile in a predominantly Chinese population. Dis Colon Rectum; 2007 Jan;50(1):75-82
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  • [Title] Mesenteric desmoid tumors in Singapore familial adenomatous polyposis patients: clinical course and genetic profile in a predominantly Chinese population.
  • PURPOSE: This study examined the mutational profile of the adenomatous polyposis coli gene in relation to the development of desmoid tumors in familial adenomatous polyposis patients from a predominantly Chinese population.
  • Identification of specific adenomatous polyposis coli gene mutation was performed and clinical course of associated desmoid disease obtained from case records and a computerized database.
  • The clinical course of desmoid tumors can be divided into stable (n=11), variable (n=3), progressive (n=6), and aggressive growth (n=3).
  • Only 3 (13 percent) patients with aggressive tumor growth required chemotherapy.
  • The most common complications related to the mesenteric desmoids were intestinal obstruction (21.7 percent), ureteric obstruction (17.4 percent), and encasement of superior mesenteric vessels (13 percent).
  • CONCLUSION: The clinical course of desmoids in an individual familial adenomatous polyposis patient remains unpredictable and no reliable genetic marker is available for prognostication in desmoid disease.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Fibromatosis, Abdominal / genetics

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  • (PMID = 17082890.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon
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75. Collins D, Myers E, Kavanagh D, Lennon G, McDermott E: Mesenteric desmoid tumor causing ureteric obstruction. Int J Urol; 2008 Mar;15(3):261-2
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  • [Title] Mesenteric desmoid tumor causing ureteric obstruction.
  • Desmoid tumors are rare, accounting for just 0.03% of all neoplasms and less than 3% of all soft tissue tumors.
  • We describe the case of a 16-year-old female who presented with hydronephroureter secondary to an intra-abdominal desmoid tumor.
  • This case report draws the attention of urologists to the diagnostic dilemma and therapeutic challenges associated with an intra-abdominal mass causing ureteral obstruction especially in young patients.
  • [MeSH-major] Fibromatosis, Aggressive / complications. Mesentery. Peritoneal Neoplasms / complications. Ureteral Obstruction / etiology

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  • (PMID = 18304225.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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76. Gouin F, Tesson A, Bertrand-Vasseur A, Cassagnau E, Rolland F: [Rating of tumoral growth in non-operated primary or recurrent extra-abdominal aggressive fibromatosis]. Rev Chir Orthop Reparatrice Appar Mot; 2007 Oct;93(6):546-54
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  • [Title] [Rating of tumoral growth in non-operated primary or recurrent extra-abdominal aggressive fibromatosis].
  • [Transliterated title] Etude de la croissance tumorale des tumeurs desmoïdes extra-abdominales (FDEA) primitives ou récidivées non opérées.
  • PURPOSE OF THE STUDY: Extra-abdominal aggressive fibromatosis (EAAF) is a benign desmoid tumor with a potentially aggressive behavior.
  • For eight, the tumor was a recurrence after surgical removal.
  • MRI showed progression for two tumors (12%) but with a short follow-up since diagnosis (9 and 14 months), in one case despite medical treatment.
  • On average the tumor growth lasted ten months.
  • DISCUSSION: Tumor growth was never noted beyond 36 months.
  • This notion of an interruption in tumor growth is mentioned sporadically in reports on EAAF, which have generally included recurrent tumors.
  • The high rate of spontaneous interruption of tumor growth must be counterbalanced with the difficult task of local treatment: the risk of recurrence is particularly high after surgery and functional sequelae can be significant when wide resection is proposed in an anatomically difficult localization.
  • [MeSH-major] Fibromatosis, Aggressive / physiopathology. Neoplasm Recurrence, Local / physiopathology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Biopsy. Chemotherapy, Adjuvant. Cohort Studies. Disease Progression. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Invasiveness. Palliative Care. Prospective Studies. Radiotherapy, Adjuvant. Remission Induction. Treatment Outcome

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  • (PMID = 18065863.001).
  • [ISSN] 0035-1040
  • [Journal-full-title] Revue de chirurgie orthopédique et réparatrice de l'appareil moteur
  • [ISO-abbreviation] Rev Chir Orthop Reparatrice Appar Mot
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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77. Yang CH, Sheen-Chen SM, Lu CC, Ko SF, Eng HL: Computed tomographic presentation of mesenteric fibromatosis. Dig Dis Sci; 2005 Feb;50(2):348-50
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  • [Title] Computed tomographic presentation of mesenteric fibromatosis.

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  • [Cites] Arch Surg. 1978 Aug;113(8):998-1000 [687099.001]
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  • (PMID = 15745099.001).
  • [ISSN] 0163-2116
  • [Journal-full-title] Digestive diseases and sciences
  • [ISO-abbreviation] Dig. Dis. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Rajakannu M, Ananthakrishnan N, Madhavan M: Isolated mesenteric fibromatosis. Trop Gastroenterol; 2008 Jul-Sep;29(3):179-80
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  • [Title] Isolated mesenteric fibromatosis.
  • Fibromatosis is a rare, locally aggressive but non-metastasising fibrous mass often associated with familial adenomatous polyposis in Gardner's Syndrome (GS).
  • Although sporadic cases occur, unlike in GS, they are predominantly extra-abdominal.
  • We report the case of a 40-year-old lady who underwent laparotomy for a large isolated abdominal mass three years after a Whipple's procedure for adenocarcinoma of the distal common bile duct.
  • A spherical, football sized tumour was found in the jejunal mesentery.
  • Resection of the tumour with jejunum was carried out.
  • This case is peculiar in that mesenteric fibromatosis occurred in a patient with prior history of periampullary carcinoma and without history of familial adenomatous polyposis.
  • [MeSH-major] Fibroma / diagnosis. Jejunal Neoplasms / diagnosis

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  • (PMID = 19115615.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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79. Rifaat MA, Abdel Gawad WS: The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation. J Egypt Natl Canc Inst; 2005 Sep;17(3):139-48
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  • [Title] The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation.
  • As a pedicled flap its reach to the lower abdomen and groin made it an attractive option for reconstructing soft tissue defects after tumor ablation.
  • Also, the adequacy of the fascia lata as a sole substitute for abdominal wall muscles has been disputable.
  • PATIENTS AND METHODS: From April 2001 to April 2004, 12 pedicled TFL flaps were used to reconstruct 5 central abdominal wall full thickness defects and 6 groin soft tissue defects following tumor resection.
  • In one case, bilateral flaps were used to reconstruct a large central abdominal wall defect.
  • From the abdominal wall defects group, all repairs were enforced primarily with a prolene mesh except for one patient who was the first in this study.
  • Patients presenting with groin defects required coverage of exposed vessels following tumor resection.
  • RESULTS: The resulting soft tissue defects in this study were due to resection of 4 abdominal wall desmoid tumors, a colonic carcinoma infiltrating the abdominal wall, 4 primary groin soft tissue sarcomas, a metastatic SCC of the leg to groin nodes, and a primary SCC of the groin.
  • Three of those cases developed in flaps reconstructing abdominal wall defects, and one case developed in a flap used to cover a groin defect.
  • Out of the 5 cases that underwent abdominal wall reconstruction, one case developed ventral hernia, in which bilateral TFL flaps were used without mesh enforcement.
  • Only one patient died of distant metastasis of a SCC of the groin skin, 8 months postoperatively and another 2 patients with abdominal desmoid tumors developed local recurrence.
  • A pedicled flap would be appropriate for lower abdominal wall defects, and is better islanded to achieve extra mobilization and allow a tension free closure, while for groin defects, simple flap transposition should be enough.
  • Nevertheless, reconstruction for full thickness abdominal wall defects by this flap is a static reconstruction.
  • [MeSH-major] Abdominal Wall / surgery. Groin / surgery. Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Abdominal Neoplasms / surgery. Adult. Fascia Lata. Female. Humans. Male. Middle Aged. Reconstructive Surgical Procedures

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  • (PMID = 16799651.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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80. Solazzo M, Marcianò P, Benzi F, Puccio F: Ileal resection and small bowel transplantation for large mesenteric desmoid tumor. Tech Coloproctol; 2005 Apr;9(1):72-3
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  • [Title] Ileal resection and small bowel transplantation for large mesenteric desmoid tumor.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Ileum / surgery. Intestine, Small / transplantation. Mesentery. Peritoneal Neoplasms / surgery

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  • (PMID = 15884154.001).
  • [ISSN] 1123-6337
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Italy
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81. Frade Mera MJ, Jacue Izquierdo S, Fontan Vinagre G, Montejo González JC: [Course and cares of intestinal transplant in immediate post-operative period]. Enferm Intensiva; 2007 Apr-Jun;18(2):61-9
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  • Reason for intestinal transplant: 75% familial adenomatous polyposis with desmoid tumor and 25% mesenteric artery obstruction.
  • All the patients were carrier of central and arterial venous catheters, and Jackson Pratt abdominal drains (50% two, 50% three).

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  • (PMID = 17570192.001).
  • [ISSN] 1130-2399
  • [Journal-full-title] Enfermeria intensiva
  • [ISO-abbreviation] Enferm Intensiva
  • [Language] SPA
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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82. Ballardini P, Gulmini L, Margutti G, Lelli G: Mesenteric fibromatosis in a patient with Camurati-Engelmann disease. A case report and literature review. Tumori; 2005 Nov-Dec;91(6):552-4
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  • [Title] Mesenteric fibromatosis in a patient with Camurati-Engelmann disease. A case report and literature review.
  • Mesenteric fibromatosis is a rare type of desmoid tumor characterized by local aggressiveness and a tendency to relapse.
  • Camurati-Engelmann disease is a very rare form of bone dysplasia characterized by osteosclerosis of the diaphyses of the long bones.
  • Here we describe the case of a male patient affected by these two rare diseases in association with chronic inflammatory intestinal disease.


83. Suresh CS, Ali AA: Desmoid tumor of the tongue. Med Oral Patol Oral Cir Bucal; 2008 Dec;13(12):E761-4
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  • [Title] Desmoid tumor of the tongue.
  • Desmoid tumors are rare neoplasms accounting for 0.03% of all neoplasms and have an estimated incidence of 2 to 4 per million per year.
  • World Health Organization currently refers to all of the deep types of fibromatosis as desmoid-type of fibromatoses.
  • The term "desmoid" refers to the hard, tendon-like appearance of the tumor.
  • About fifty percent of desmoid tumors arise in the abdominal region.
  • The extra-abdominal desmoid tumors present a difficult problem in recognition and management especially because of the striking discrepancy between its deceptively harmless microscopic appearance and its potential to attain a large size, to recur, and to infiltrate neighboring tissues in the manner of a fibrosarcoma.
  • Desmoid tumors are very rare in the oral cavity with less than 5% of cases constituting oral soft tissue fibromatosis.
  • A 22-year old mentally retarded female patient with desmoid tumor occurring in the tongue is presented here.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Tongue Neoplasms / pathology

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  • (PMID = 19047962.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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84. Bruce AG, Bakke AM, Thouless ME, Rose TM: Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons. Virol J; 2005 Jan 05;2:2
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  • These primers showed little similarity to the corresponding sequences of the macaque RV1 rhadinoviruses, retroperitoneal fibromatosis herpesvirus Macaca nemestrina (RFHVMn) and Macaca mulatta (RFHVMm).

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  • (PMID = 15634356.001).
  • [ISSN] 1743-422X
  • [Journal-full-title] Virology journal
  • [ISO-abbreviation] Virol. J.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / RR13154; United States / NCRR NIH HHS / RR / P51 RR000166; United States / NCRR NIH HHS / RR / R24 RR023343; United States / NIAID NIH HHS / AI / K02 AI49275; United States / NCRR NIH HHS / RR / R01 RR013154; United States / NIAID NIH HHS / AI / K02 AI049275; United States / NCRR NIH HHS / RR / RR00166
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC544863
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85. Amiot A, Dokmak S, Sauvanet A, Vilgrain V, Bringuier PP, Scoazec JY, Sastre X, Ruszniewski P, Bedossa P, Couvelard A: Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion. JOP; 2008;9(3):339-45
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  • [Title] Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion.
  • CONTEXT: Desmoid tumors are rare, benign soft tissue tumors, characterized by the proliferation of fibroblasts in an abundant collagen extra-cellular matrix.
  • Intra-abdominal forms involve the mesentery and retroperitoneum and usually occur associated with familial adenomatous polyposis or Gardner's syndrome.
  • Although desmoid tumors do not metastasize, their evolution can be life-threatening due to aggressive local invasion, such as mesentery involvement.
  • CASE REPORT: We herein report a very rare location of sporadic desmoid tumors involving the pancreatic tail, presenting as a cystic lesion.
  • A 51-year-old woman presented with recurrent abdominal pain and weight loss.
  • The diagnosis of mucinous cystadenocarcinoma was suspected preoperatively and the patient underwent a splenopancreatectomy with en-bloc resection of the left colonic flexure, duodenojejunal junction and part of the posterior gastric wall.
  • Pathological analysis revealed fibroblastic proliferation arising in musculoaponeurotic structures consistent with a desmoid tumor.
  • The diagnosis was confirmed by immunocytochemical analysis and the assessment of the beta-catenin gene mutation.
  • No treatment was given postoperatively to prevent desmoid tumor recurrence.
  • CONCLUSION: Desmoid tumors are very rare in the pancreas and their diagnosis can be difficult, such as in our case where it presented as a cystic lesion.
  • In contrast to intra-abdominal forms, sporadic pancreatic desmoid tumors are more frequent than those associated with familial adenomatous polyposis.
  • [MeSH-major] Fibromatosis, Abdominal / etiology. Pancreatic Cyst / complications
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Female. Humans. Middle Aged

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  • (PMID = 18469451.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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86. Azizi L, Balu M, Belkacem A, Lewin M, Tubiana JM, Arrivé L: MRI features of mesenteric desmoid tumors in familial adenomatous polyposis. AJR Am J Roentgenol; 2005 Apr;184(4):1128-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] MRI features of mesenteric desmoid tumors in familial adenomatous polyposis.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Fibromatosis, Abdominal / pathology. Magnetic Resonance Imaging. Mesentery / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans


87. Stengel G, Metze D, Dörflinger B, Luger TA, Böhm M: Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon. J Am Acad Dermatol; 2008 Aug;59(2 Suppl 1):S7-9
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  • [Title] Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon.
  • Aggressive fibromatosis (desmoid tumor) is a very rare neoplasm arising from the musculoaponeurotic structures.
  • We report on a young woman with a large desmoid tumor of the left foot.
  • Long-term immunointervention with pegylated interferon alfa-2b, however, led to marked clinical improvement of the patient's condition and a radiologically proven stabilization of the disease.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Fibromatosis, Aggressive / drug therapy. Foot. Interferon-alpha / administration & dosage. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 18625396.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 99210-65-8 / interferon alfa-2b
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88. Rosato L, Mondini G, Serbelloni M, Bertone P, Orlassino R, Cossavella D: [Intra-abdominal desmoid tumors: rare but important disease]. G Chir; 2007 Jan-Feb;28(1-2):20-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intra-abdominal desmoid tumors: rare but important disease].
  • Desmoid tumors are rare benign neoplasms with high tendency to local recurrence, and they can be divided into extra- and intra-abdominal types (mesenteric fibromatosis).
  • Six patients (3 men and 3 women) affected by extra-abdominal desmoid tumors have been treated with radical excision.
  • In two patients desmoid was intra-abdominal:.
  • 1) a 55 years old man admitted for acute abdomen and submitted, in emergency, to a laparotomy with excision of a mesenteric abscess including a jejunal loop at about one meter from Treitz;.
  • 2) 52 years old man, submitted to an elective excision of a capsulated neoplasm of the little omentum, which had caused an oppressive abdominal pain.
  • In both cases the hystological diagnosis has been desmoid tumor.
  • Surgical treatment of desmoid tumors must aim at radical excision to avoid frequent recurrences (25-65%); these have stimulated the research of other kinds of treatments, since a new surgical operation itself can lead to a further recurrence.
  • Radiotherapy has been investigated with results in 79-96% of cases, antiestrogenic therapy has been used with success in 51% of patients, and high dose tamoxifen seemed to obtain a stable disease in non operable cases.
  • Conclusive results on the efficacy of these treatments have not been obtained yet, because of the rarity of the desmoid tumors even in greater Centres.
  • [MeSH-major] Fibromatosis, Abdominal / surgery. Mesentery. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Abdominal Neoplasms / pathology. Abdominal Neoplasms / surgery. Aged. Female. Fibromatosis, Aggressive / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17313728.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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89. Basu S, Nair N, Banavali S: Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management. Br J Radiol; 2007 Sep;80(957):750-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management.
  • In this preliminary report, we explore the uptake pattern of fluorodeoxyglucose (FDG) in fibromatosis and hypothesize the potential clinical role of FDG-positron emission tomography (PET) in the management of this benign but locally aggressive heterogeneous group of soft-tissue tumours.
  • Five patients were studied (two men and three women, age range 23-35 years), among whom were three cases of deep musculoskeletal fibromatosis, one of abdominal fibromatosis (abdominal desmoid) associated with familial adenomatous polyposis (Gardner's syndrome) and one case of both deep musculoskeletal fibromatosis and abdominal desmoid.
  • The maximum standardized uptake value (SUV(max)) observed was up to 4.7; the avidity probably related to the biological aggressiveness and tendency for recurrence, characteristic of fibromatosis.
  • Hence, a baseline FDG-PET can serve a valuable role in monitoring the effect of systemic pharmacotherapy in patients with recurrent progressive disease after unsuccessful local-regional treatment.
  • The findings in this report can be extrapolated and have implications for studying the utility of FDG-PET in defining aggressiveness, guiding biopsy and defining excision site in a large tumour and in monitoring therapy in fibromatosis.
  • [MeSH-minor] Adult. Female. Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / radiography. Fibromatosis, Abdominal / radionuclide imaging. Gardner Syndrome / complications. Humans. Male. Positron-Emission Tomography. Recurrence. Retrospective Studies

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  • (PMID = 17709361.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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90. Sakorafas GH, Nissotakis C, Peros G: Abdominal desmoid tumors. Surg Oncol; 2007 Aug;16(2):131-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abdominal desmoid tumors.
  • Desmoid tumors are rare, benign, fibromatous lesions that are the result of abnormal proliferation of myofibroblasts.
  • Desmoid tumors can be classified as extra-abdominal and abdominal.
  • Abdominal desmoid tumors are either superficial or intraabdominal.
  • These tumors are associated with a high recurrence rates, even if their microscopic characters indicate a benign disease; their biologic behavior often indicates rather a "malignant" disease, which can cause even the death.
  • Intraabdominal desmoid tumors can engulf surrounding viscera and vessels, thereby greatly complicating their surgical treatment.
  • [MeSH-major] Abdominal Neoplasms / pathology. Abdominal Neoplasms / therapy. Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / therapy
  • [MeSH-minor] Algorithms. Diagnosis, Differential. Diagnostic Imaging. Genetic Testing. Humans. Medical History Taking

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  • (PMID = 17719772.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 86
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91. McCormack D, Kesha K, Tittle SL, Saldinger PF: Mesenteric fibromatosis mimicking a gastrointestinal stromal tumor. Conn Med; 2010 Apr;74(4):197-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric fibromatosis mimicking a gastrointestinal stromal tumor.
  • Mesenteric fibromatosis is a locally aggressive tumor of the mesentery with a high propensity for bowel involvement.
  • Mesenteric fibromatosis often mimics gastrointestinal stromal tumors in size, location and immunohistochemical features.
  • We report the case of a 30-year-old male who underwent resection of a mesenteric tumor, initially diagnosed as gastrointestinal stromal tumor.
  • The tumor was categorized as high-risk and the patient was treated with chemotherapy.
  • The tumor did not respond to medical management.
  • The patient underwent a second en bloc resection and pathology results were conclusive for mesenteric fibromatosis.
  • This case highlights the significance of accurately differentiating mesenteric fibromatosis from gastrointestinal stromal tumor.
  • Making a concrete diagnosis is often difficult because both gastrointestinal stromal tumors and mesenteric fibromatosis share a number of morphological and immunohistochemical features including CKIT expression.
  • [MeSH-major] Diagnostic Errors. Fibromatosis, Abdominal / diagnosis. Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Humans. Male

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  • (PMID = 20440999.001).
  • [ISSN] 0010-6178
  • [Journal-full-title] Connecticut medicine
  • [ISO-abbreviation] Conn Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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92. Domínguez Menéndez JA, Aguirrezábal Arredondo A, del Cura Rodríguez JL, Zabala Landa RM: [Management of a desmoid tumor using percutaneous injection of 50% acetic acid]. Farm Hosp; 2006 Sep-Oct;30(5):320-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Management of a desmoid tumor using percutaneous injection of 50% acetic acid].
  • [Transliterated title] Tratamiento de un tumor desmoide mediante inyección percutánea de ácido acético 50%
  • [MeSH-major] Abdominal Neoplasms / drug therapy. Acetic Acid / administration & dosage. Fibromatosis, Aggressive / drug therapy. Indicators and Reagents / administration & dosage

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  • (PMID = 17166071.001).
  • [ISSN] 1130-6343
  • [Journal-full-title] Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria
  • [ISO-abbreviation] Farm Hosp
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Indicators and Reagents; Q40Q9N063P / Acetic Acid
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93. Johner A, Tiwari P, Zetler P, Wiseman SM: Abdominal wall desmoid tumors associated with pregnancy: current concepts. Expert Rev Anticancer Ther; 2009 Nov;9(11):1675-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abdominal wall desmoid tumors associated with pregnancy: current concepts.
  • The desmoid tumors (DTs) are unusual soft-tissue tumors that have a propensity for aggressive local growth and may develop during, or soon after pregnancy.
  • Pregnancy-associated DTs are uncommon and optimal management of this tumor has yet to be defined.
  • Currently, controversy centers on the timing of surgical resection and is influenced by the potential for tumor growth and the effects of a gravid uterus.
  • [MeSH-major] Abdominal Wall / surgery. Fibromatosis, Aggressive / surgery. Pregnancy Complications, Neoplastic / surgery

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  • (PMID = 19895250.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 78
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94. Rampone B, Pedrazzani C, Marrelli D, Pinto E, Roviello F: Updates on abdominal desmoid tumors. World J Gastroenterol; 2007 Dec 7;13(45):5985-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Updates on abdominal desmoid tumors.
  • Desmoid tumor is a monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures.
  • Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons.
  • The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations difficult.
  • [MeSH-major] Fibromatosis, Abdominal / therapy. Neoplasm Recurrence, Local

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  • (PMID = 18023087.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 50
  • [Other-IDs] NLM/ PMC4250878
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95. Bethune R, Amin A: Mesenteric fibromatosis: a rare cause of acute abdominal pain. Ann R Coll Surg Engl; 2006 Mar;88(2):1-2
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  • [Title] Mesenteric fibromatosis: a rare cause of acute abdominal pain.
  • A 45-year-old man, with a previous history of astrocytoma, presented with diffuse abdominal pain.
  • A CT scan was non-specific and the pain worsened; his abdomen became peritonitic on examination.
  • An exploratory laparotomy was performed, and a large small bowel mesenteric mass was found together with an associated haematoma.
  • Subsequent histology showed the tumour to be a benign fibromatosis, and the patient recovered uneventfully.
  • There were no reports in the literature of any association between astrocytomas and fibromatosis.
  • Mesenteric fibromatosis is a rare tumour often associated with Gardner's syndrome.
  • [MeSH-major] Abdominal Pain / etiology. Fibroma / complications. Ileal Diseases / complications. Mesentery
  • [MeSH-minor] Acute Disease. Astrocytoma / complications. Colonic Diseases / complications. Diagnosis, Differential. Gastrointestinal Hemorrhage / complications. Hematoma / complications. Humans. Male. Middle Aged

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  • (PMID = 16884606.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 5
  • [Other-IDs] NLM/ PMC1963641
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96. Colović R, Grubor N, Radak V, Micev M, Stojković M, Colović N: [Aggressive intraabdominal fibromatosis]. Vojnosanit Pregl; 2006 Sep;63(9):839-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Aggressive intraabdominal fibromatosis].
  • BACKGROUND: Intraabdominal or mesenteric fibromatosis is a rare benign nonmetastatic neoplasm that appears as a sporadic lesion or in patients with familiar polyposis.
  • CASE REPORT: We presented a 22-year-old woman in whom an aggressive intraabdominal fibromatosis had appeared during the first pregnancy as a well circumscribed ovoid tumor, involving the terminal ileum, the caecum, the ascending colon, the right kidney, the ureter, and the right common iliac artery.
  • The tumor was excised with right colectomy, nephroureterectomy and resection of the involved artery using arterial reconstruction with graft interposition.
  • Two years after the surgery the patient developed an inoperable tumor recurrency with a fatal outcome.
  • CONCLUSION: In spite of a successful surgical excision during the original surgery intraabdominal or mesenteric fibromatosis might have an aggressive evolution leading to an inoperable tumor recurrency and a fatal outcome.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Neoplasm Recurrence, Local. Pregnancy Complications, Neoplastic / pathology


97. Basdanis G, Papadopoulos VN, Panidis S, Tzeveleki I, Karamanlis E, Mekras A, Apostolidis S, Michalopoulos A: Desmoid tumor of mesentery in familial adenomatous polyposis: a case report. Tech Coloproctol; 2010 Nov;14 Suppl 1:S61-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor of mesentery in familial adenomatous polyposis: a case report.
  • While a mass in the left lateral abdominal region was palpated.
  • Pathological examination revealed a desmoid tumor of the mesentery.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Fibromatosis, Aggressive / surgery. Neoplasms, Second Primary / surgery. Peritoneal Neoplasms / surgery


98. Rakha EA, Kandil MA, El-Santawe MG: Gigantic recurrent abdominal desmoid tumour: a case report. Hernia; 2007 Apr;11(2):193-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gigantic recurrent abdominal desmoid tumour: a case report.
  • Deeply seated fibromatosis or desmoid tumour (DT) is a rare entity characterized by benign proliferation of fibroblasts.
  • Although non-malignant, this tumour can be life-threatening due to its invasive property and high recurrence rate.
  • We report a unique case of a huge recurrent abdominal DT (36 cm in diameter, 25 kg in weight) that caused pressure necrosis and sloughing of the overlying anterior abdominal wall, and produced a large fungating mass protruding outside the abdomen.
  • Although preoperative neoadjuvant therapies were all ineffective, radical surgical removal of the tumour was successful.
  • The procedure was followed by an excellent clinical recovery and the patient is still alive with no evidence of recurrent disease after a 6-year follow-up.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Neoplasm Recurrence, Local / pathology

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  • (PMID = 17149531.001).
  • [ISSN] 1265-4906
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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99. Eren S: A sporadic abdominal desmoid tumour case presenting with intermittent intestinal obstruction. Eur J Pediatr Surg; 2005 Jun;15(3):196-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A sporadic abdominal desmoid tumour case presenting with intermittent intestinal obstruction.
  • Desmoid tumours, also known as aggressive fibromatoses, are rare lesions having intermediate biological behaviour between benign fibrous lesions and fibrosarcomas.
  • Although abdominal desmoids have an increased incidence in Gardner's syndrome, they are rarely found in isolated form.
  • Although intraabdominal desmoids are usually detected as a solitary lesion in sporadic cases, the case presented here had two mesenteric lesions in the left upper quadrant.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Intestinal Obstruction / complications. Mesentery. Peritoneal Neoplasms / diagnosis

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  • (PMID = 15999314.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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100. Fimmanò A, Coppola Bottazzi E, Cirillo C, Tammaro P, Casazza D: [Desmoid tumor of the chest wall foiling surgery]. Ann Ital Chir; 2006 Mar-Apr;77(2):169-72; discussion 172
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Desmoid tumor of the chest wall foiling surgery].
  • [Transliterated title] Desmoide della parete toracica, ad insorgenza postchirurgica.
  • The anatomo-pathological test showed a desmoid fibromatosis (desmoid tumor) extra-abdominal (12.5 x 9 x 5 cm).
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Thoracic Wall

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  • (PMID = 17147093.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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