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1. González MA, Menéndez R, Ayala JM, Herrero M, Cuesta J, Domínguez A, Martínez M, Graña JL, Pozo F: [Intra-abdominal desmoid tumor]. Cir Esp; 2005 Jun;77(6):362-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intra-abdominal desmoid tumor].
  • [Transliterated title] Tumor desmoide intraabdominal.
  • Aggressive fibromatosis (desmoid tumor) are rare connective tissue tumors that occur sporadically or in association with familial adenomatous polyposis.
  • Biopsy is required to establish the diagnosis.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16420952.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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2. Lawatsch EJ, Datta MW, Van Tuinen P, Sudakoff GS, Davis NB, Langenstroer P: Intra-abdominal desmoid tumor following retroperitoneal lymph node dissection for testicular germ cell tumor. Int J Urol; 2006 Jan;13(1):84-6
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  • [Title] Intra-abdominal desmoid tumor following retroperitoneal lymph node dissection for testicular germ cell tumor.
  • In the testicular cancer post-treatment setting a rapidly growing retroperitoneal mass leads to a differential diagnosis including recurrent germ cell tumor, residual mature teratoma, or sarcomatoid degeneration.
  • We report the case of a 27-year-old man with a large abdominal mass occurring in the setting of a mixed germ cell tumor after radical orchiectomy with primary chemotherapy followed by retroperitoneal lymph node dissection.
  • Surgical excision of this mass followed by pathological review revealed an intra-abdominal desmoid tumor.
  • Fluorescence in situ hybridization (FISH) for isochromosome 12p failed to demonstrate a germ cell tumor origin.
  • This is the fourth such case of an intra-abdominal desmoid tumor after retroperitoneal lymph node dissection for testicular cancer in the urologic literature.
  • This case highlights the need for careful consideration of a desmoid tumor when a rapidly growing spindle cell tumor is encountered in a post-treatment testis cancer patient.
  • [MeSH-major] Abdominal Neoplasms / complications. Fibromatosis, Aggressive / complications. Lymph Node Excision. Neoplasms, Germ Cell and Embryonal / surgery. Testicular Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Humans. Laparotomy. Male. Orchiectomy / adverse effects. Retroperitoneal Space. Tomography, X-Ray Computed

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  • (PMID = 16448440.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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3. Hatzimarkou A, Filippou D, Papadopoulos V, Filippou G, Rizos S, Skandalakis P: Desmoid tumor in Gardner's Syndrome presented as acute abdomen. World J Surg Oncol; 2006;4:18

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor in Gardner's Syndrome presented as acute abdomen.
  • BACKGROUND: Gardner's syndrome can occasionally be complicated with intra-abdominal desmoid tumor.
  • CASE PRESENTATION: A rare case of a 41-year-old male patient with Gardner's syndrome complicated with intra-abdominal desmoid tumor, which first presented as acute abdomen, is presented.
  • CONCLUSION: Extra-abdominal manifestations of Gardner's syndrome along with a palpable abdominal mass would raise suspicion for the presence of a desmoid tumor in the majority of cases.

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  • (PMID = 16569244.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1479346
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4. Viriyaroj V, Yingsakmongkol N, Pasukdee P, Rermluk N: A large abdominal desmoid tumor associated with pregnancy. J Med Assoc Thai; 2009 Jun;92 Suppl 3:S72-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A large abdominal desmoid tumor associated with pregnancy.
  • Desmoid tumors are rare, benign tumors with locally aggressive behavior which originate from fascial or musculoaponeurotic structure.
  • The etiology of desmoid tumors are uncertain but may be related to operation, trauma or hormonal factors.
  • The authors report a 17-year old woman, gravida 1, para 1 with a mass at her lower abdominal wall during the fifth month of gestation.
  • She was biopsied during delivery in another hospital but was not given a definite diagnosis.
  • The tumor measured 28 x 21 x 18 centimeters in size and 4,900 g in weight.
  • Complete surgical excision was performed The pathological report was desmoid tumor (aggressive fibromatosis).
  • She had no post-operative complication and no recurrent tumor in the 8 months after operation.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibromatosis, Aggressive / diagnosis. Pregnancy Complications

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  • (PMID = 19702071.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Thailand
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5. Venkat D, Levine E, Wise WE: Abdominal pain and colonic obstruction from an intra-abdominal desmoid tumor. Gastroenterol Hepatol (N Y); 2010 Oct;6(10):662-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abdominal pain and colonic obstruction from an intra-abdominal desmoid tumor.

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  • (PMID = 21103447.001).
  • [ISSN] 1554-7914
  • [Journal-full-title] Gastroenterology & hepatology
  • [ISO-abbreviation] Gastroenterol Hepatol (N Y)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2978418
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6. Valejo FA, Tiezzi DG, Nai GA: [Abdominopelvic desmoid tumor]. Rev Bras Ginecol Obstet; 2009 Jan;31(1):35-40
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  • [Title] [Abdominopelvic desmoid tumor].
  • [Transliterated title] Tumor desmoide abdômino-pélvico.
  • Desmoid tumor is a noncapsulated neoplasia, locally aggressive, originated from the fibroblasts of the musculo-aponeurotic tissues.
  • Even though with no malignant behavior, such as the ability of generating metastasis or of invasion, the desmoid tumor has a high tendency for local growth, causing deformities in the adjacent organs, pain and sometimes organ dysfunction, depending on the area involved.
  • We report the case of a large intra-abdominal desmoid tumor, invading pelvic organs in a 53 year-old patient.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Pelvic Neoplasms / pathology

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  • (PMID = 19347227.001).
  • [ISSN] 1806-9339
  • [Journal-full-title] Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
  • [ISO-abbreviation] Rev Bras Ginecol Obstet
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Brazil
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7. Bhama PK, Chugh R, Baker LH, Doherty GM: Gardner's syndrome in a 40-year-old woman: successful treatment of locally aggressive desmoid tumors with cytotoxic chemotherapy. World J Surg Oncol; 2006;4:96
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gardner's syndrome in a 40-year-old woman: successful treatment of locally aggressive desmoid tumors with cytotoxic chemotherapy.
  • BACKGROUND: Desmoid tumors that present as a part of Gardener's syndrome can present very difficult management problems.
  • CASE PRESENTATION: We report a case of intra-abdominal desmoid tumor causing distal small bowel obstruction that complicated the management of a more proximal enterocutaneous fistula from the jejunum.
  • After failure of more conventional management options including imatinib, the patient's disease responded to doxorubicin and ifosfamide.
  • CONCLUSION: Systemic cytotoxic therapy with doxorubicin and ifosfamide can be useful for patients with complications from intra-abdominal desmoid tumor.

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  • (PMID = 17173703.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1716167
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8. Al-Otaibi ML, Turcotte RE, Hings I, Beaudet J, Isler M, Nahal A, Wong C: Low-dose chemotherapy for extra-abdominal desmoid tumor. Saudi Med J; 2008 Dec;29(12):1730-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Low-dose chemotherapy for extra-abdominal desmoid tumor.
  • OBJECTIVE: To assess the outcome of patients with extra-abdominal desmoid tumor treated with low dose chemotherapy (methotrexate and vinblastine) both for tumor response and treatment related toxicity.
  • METHODS: We retrospectively reviewed the outcome of 12 patients who underwent low dose chemotherapy for extra abdominal desmoid of different locations.
  • We evaluated the patients for their compliance, tumor response, complications of treatment, and impact of treatment on symptoms.
  • RESULTS: Disease related morbidity included pain in 7 patients, functional limitation in 7 and cosmetic defects in 3.
  • The mean tumor size was 11 cm (3-20 cm).

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  • (PMID = 19082222.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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9. Rosoff PM, Larrier N, Rice HE: Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease. Pediatr Blood Cancer; 2005 Oct 15;45(5):728-31
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  • [Title] Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease.
  • The risk of second malignancies after successful treatment for Hodgkin disease can be considerable.
  • We describe a young woman who developed an intra-abdominal desmoid tumor more than 4 years after completing therapy for Stage IIB Hodgkin disease, treated with combination chemotherapy (ABVD) and mantle irradiation.
  • The tumor did not occur at either a surgical site or within a radiation field.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibromatosis, Aggressive / diagnosis. Hodgkin Disease / therapy. Neoplasms, Second Primary / diagnosis

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  • (PMID = 16035093.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Durkin AJ, Korkolis DP, Al-Saif O, Zervos EE: Full-term gestation and transvaginal delivery after wide resection of an abdominal desmoid tumor during pregnancy. J Surg Oncol; 2005 Feb 1;89(2):86-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Full-term gestation and transvaginal delivery after wide resection of an abdominal desmoid tumor during pregnancy.
  • A 29-year-old female was diagnosed with a symptomatic, extra-abdominal desmoid tumor during the first trimester of pregnancy.
  • Preoperative diagnosis was confirmed by core-needle biopsy of the lesion.
  • At 20-weeks gestation, wide local resection of the tumor with disease-free margins, as well as abdominal wall reconstruction with polytetrafluoroethylene (PTFE) mesh was successfully undertaken.
  • Histological examination of the tumor ex vivo confirmed that the lesion was a desmoid tumor consisting of spindle cells with dense infiltrating collagenous fibers.
  • This case illustrates the probable contribution of estrogens towards desmoid tumor development, the durability of abdominal wall reconstruction when subjected to the extraordinary strain of both a gravid uterus and labor, as well as the safety and efficacy of aggressive surgical therapy during pregnancy.
  • [MeSH-major] Abdominal Wall / surgery. Delivery, Obstetric. Fibromatosis, Abdominal / surgery. Pregnancy Complications, Neoplastic / surgery


11. Kourda N, Ben Slama S, Mrabet N, Sayari S, Zouache A, Ben Jilani SB, Zermani R: [Abdominal desmoid tumor: pathologic and therapeutic concepts]. Tunis Med; 2008 Oct;86(10):916-20
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  • [Title] [Abdominal desmoid tumor: pathologic and therapeutic concepts].
  • [Transliterated title] Tumeur desmoide abdominale: concepts histopathologiques et therapeutiques.
  • BACKGROUND: Abdominal desmoid tumors arise in young adults between 20 and 40 years.
  • METHODS: From 1990 to 2004, three cases of abdominal desmoid tumors were diagnosed in the Pathologic laboratory of the Charles Nicole Hospital of Tunis.
  • CONCLUSION: Abdominal desmoid tumors are locally aggressive but never give metastasis.
  • [MeSH-major] Abdominal Neoplasms / pathology. Abdominal Neoplasms / therapy. Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / therapy

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  • (PMID = 19472812.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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12. de Ferro SM, Suspiro A, Fidalgo P, Lage P, Rodrigues P, Fragoso S, Vitoriano I, Baltazar C, Albuquerque C, Bettencourt A, Leitão CN: Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case. Dis Colon Rectum; 2009 Apr;52(4):742-5
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  • [Title] Aggressive phenotype of MYH-associated polyposis with jejunal cancer and intra-abdominal desmoid tumor: report of a case.
  • MYH-associated polyposis is an inherited autosomal recessive disease, linked to biallelic germline MYH mutations, which predisposes to the development of multiple colorectal adenomas and cancer.
  • When he was 39 years old, he developed three synchronous jejunal adenocarcinomas and a mesenteric desmoid tumor.
  • Similar to patients with familial adenomatous polyposis, desmoid tumors also may be part of the clinical spectrum of MYH-associated polyposis and may prove to be a significant clinical problem in patients submitted to prophylactic colectomy.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms / genetics. Fibromatosis, Aggressive / genetics. Jejunal Neoplasms / genetics. Neoplasms, Multiple Primary / genetics. Peritoneal Neoplasms / genetics
  • [MeSH-minor] Adenocarcinoma / genetics. Adenoma / genetics. Adult. DNA Glycosylases / genetics. Duodenal Neoplasms / genetics. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Intestinal Neoplasms / genetics. Intestinal Obstruction / etiology. Liver Neoplasms / secondary. Male. Mesentery. Mutation. Phenotype. Syndrome

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  • (PMID = 19404084.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 3.2.2.- / DNA Glycosylases
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13. Mátrai Z, Papp J, Polgár C, Hitre E, Köves I, Oláh E, Andi J, Kiss A, Vámosi Nagy I, Tóth L, Orosz Z: [Long-term experience with therapy of a female patient with Gardner's syndrome, first presenting with extra-abdominal desmoid tumor, and review of the literature]. Magy Seb; 2009 Apr;62(2):75-82
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  • [Title] [Long-term experience with therapy of a female patient with Gardner's syndrome, first presenting with extra-abdominal desmoid tumor, and review of the literature].
  • [Transliterated title] Extraabdominalis desmoid tumorral megjeleno Gardner-syndromás beteg kezelésével szerzett hosszú távú tapasztalataink és irodalmi áttekintés.
  • Gardner's syndrome is a clinical subgroup of familial adenomatous polyposis, an autosomal dominant disease.
  • Aggressive desmoid tumours can be very difficult to manage in patients with Gardner's syndrome.
  • We present a case of a 17-year-old female who presented with an aggressive desmoid tumor arising of the lumbar area as part of her Gardner's syndrome.
  • We conclude that desmoid tumors can precede gastrointestinal manifestations of familial adenomatous polyposis or Gardner's syndrome.
  • Desmoid tumours should be managed in a multidisciplinary setting, as well.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / genetics. Gardner Syndrome / diagnosis. Gardner Syndrome / genetics. Genes, APC

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  • (PMID = 19386568.001).
  • [ISSN] 0025-0295
  • [Journal-full-title] Magyar sebészet
  • [ISO-abbreviation] Magy Seb
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Hungary
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Hormonal
  • [Number-of-references] 30
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14. Paradol PO, Toussoun G, Delbaere M, Delaporte T, Delay E: [Extra-abdominal desmoid tumor in a scar of donor-site of a latissimus dorsi flap: case report]. Ann Chir Plast Esthet; 2008 Feb;53(1):63-9
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  • [Title] [Extra-abdominal desmoid tumor in a scar of donor-site of a latissimus dorsi flap: case report].
  • [Transliterated title] Tumeur desmoïde extra-abdominale survenue sur cicatrice de prélèvement de lambeau de grand dorsal: à propos d'un cas.
  • We will discuss one case of desmoid tumor arising from a latissimus dorsi flap donor-site scar.
  • The biopsy showed an extra-abdominal desmoid tumor.
  • [MeSH-major] Cicatrix / complications. Fibromatosis, Aggressive / etiology. Mammaplasty / adverse effects. Skin Neoplasms / etiology. Surgical Flaps / adverse effects

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  • (PMID = 17418929.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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15. Komatsu S, Ichikawa D, Kurioka H, Koide K, Ueshima Y, Shioaki Y, Lee CJ, Mutoh F, Hosokawa Y, Oka T, Yamagishi H: Intra-abdominal desmoid tumor mimicking lymph node recurrence after gastrectomy for gastric cancer. J Gastroenterol Hepatol; 2006 Jul;21(7):1224-6
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  • [Title] Intra-abdominal desmoid tumor mimicking lymph node recurrence after gastrectomy for gastric cancer.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adenocarcinoma / surgery. Fibromatosis, Aggressive / diagnosis. Gastrectomy. Neoplasm Recurrence, Local / diagnosis. Stomach Neoplasms / surgery
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16824087.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Australia
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16. Prat A, Peralta S, Cuéllar H, Ocaña A: Hepatic pneumatosis as a complication of an abdominal desmoid tumor. J Clin Oncol; 2007 Mar 1;25(7):897-8
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  • [Title] Hepatic pneumatosis as a complication of an abdominal desmoid tumor.
  • [MeSH-major] Fibromatosis, Abdominal / complications. Liver Diseases / etiology
  • [MeSH-minor] Adult. Gases. Humans. Male. Radiography, Abdominal. Tomography, X-Ray Computed

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  • (PMID = 17327611.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Gases
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17. Kreuzberg B, Koudelova J, Ferda J, Treska V, Spidlen V, Mukensnabl P: Diagnostic problems of abdominal desmoid tumors in various locations. Eur J Radiol; 2007 May;62(2):180-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic problems of abdominal desmoid tumors in various locations.
  • BACKGROUND: Abdominal desmoid tumor is one of the forms of deep (musculoaponeurotic) fibromatosis.
  • It occurs more often as a desmoid tumor in the abdominal wall, less often in various intra-abdominal locations.
  • In this work, we performed retrospective study concerning diagnostic problems of this disease with the use of imaging techniques.
  • RESULTS: The findings were typical only in the case with the lesion located in the abdominal wall, three described cases of the intra-abdominal desmoid provided a broad range of differentially diagnostic possibilities (metastases, GIT tumors, lymphomas, etc.).
  • In particular, the findings in infiltrative processes in intra-abdominal location and retroperitoneal involvement were less typical.
  • CONCLUSION: The possibility of the occurrence of intra-abdominal desmoid tumor must be considered particularly in younger individuals with rapidly growing tumorous process, which does not immediately arise from the surrounding organs (digestive tract, internal genitalia, etc.
  • ), and is located in the abdominal wall or in the abdominal cavity.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Aggressive / diagnosis
  • [MeSH-minor] Abdominal Cavity / pathology. Abdominal Wall / pathology. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17321093.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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18. Dumont AG, Lev D, Lazar A, Joensuu H, Trent J: Simultaneous gastrointestinal stromal tumor (GIST) and desmoid fibromatosis (DF). J Clin Oncol; 2009 May 20;27(15_suppl):10568

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous gastrointestinal stromal tumor (GIST) and desmoid fibromatosis (DF).
  • : 10568 Background: Desmoid Fibromatosis (DF) is one of a group of rare fibrous tissue proliferations (2-4 cases per year per million) which tend to be locally aggressive but have no propensity for metastasis.
  • Gastrointestinal Stromal Tumor (GIST) is the most common mesenchymal tumors of the gastrointestinal tract and also rare (15-20 cases per year per million).
  • The primary site of the GIST was gastric in 4 cases and the others were jejunal and mesenteric.
  • The 3 others were intra-abdominal DF.

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  • (PMID = 27963790.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Collins D, Myers E, Kavanagh D, Lennon G, McDermott E: Mesenteric desmoid tumor causing ureteric obstruction. Int J Urol; 2008 Mar;15(3):261-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric desmoid tumor causing ureteric obstruction.
  • Desmoid tumors are rare, accounting for just 0.03% of all neoplasms and less than 3% of all soft tissue tumors.
  • We describe the case of a 16-year-old female who presented with hydronephroureter secondary to an intra-abdominal desmoid tumor.
  • This case report draws the attention of urologists to the diagnostic dilemma and therapeutic challenges associated with an intra-abdominal mass causing ureteral obstruction especially in young patients.
  • [MeSH-major] Fibromatosis, Aggressive / complications. Mesentery. Peritoneal Neoplasms / complications. Ureteral Obstruction / etiology

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  • (PMID = 18304225.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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20. Lee BD, Lee W, Oh SH, Min SK, Kim EC: A case report of Gardner syndrome with hereditary widespread osteomatous jaw lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Mar;107(3):e68-72
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Gardner syndrome (GS) is an abnormality of familial adenomatous polyposis accompanied by characteristic jaw lesions.
  • Gardner syndrome intestinal polyps have a 100% risk of undergoing malignant transformation; consequently, early identification and surgical intervention of the disease are important to prolong the life of the patient.
  • Familial adenomatous polyposis, osteomatous jaw and ocular lesions, several dental abnormalities, and an abdominal desmoid tumor are the characteristic features of this case.
  • [MeSH-minor] Cementoma / diagnosis. Diagnosis, Differential. Ethmoid Sinus. Female. Genetic Diseases, Inborn. Humans. Middle Aged. Odontoma / etiology. Orbital Neoplasms / etiology. Paranasal Sinus Neoplasms / etiology

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  • (PMID = 19157925.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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21. Mazzocchi M, Onesti MG, Di Ronza S, Scuderi N: Breast desmoid tumor after augmentation mammoplasty: two case reports. Acta Chir Plast; 2009;51(3-4):73-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Breast desmoid tumor after augmentation mammoplasty: two case reports.
  • Desmoid tumor of the breast is a rare fibroblastic disease, a slow-growing and histologically benign lesion that accounts for 0.2% of all breast tumors.
  • We describe two cases of breast desmoid tumor after breast augmentation.
  • The results of this histological examination suggested an extra-abdominal desmoid tumor.
  • [MeSH-major] Breast Implantation. Breast Neoplasms / surgery. Fibromatosis, Aggressive / surgery. Postoperative Complications / surgery

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  • (PMID = 20514891.001).
  • [ISSN] 0001-5423
  • [Journal-full-title] Acta chirurgiae plasticae
  • [ISO-abbreviation] Acta Chir Plast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Czech Republic
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22. Yu YH, Son BK, Jun DW, Kim SH, Jo YJ, Park YS, Hong BW, Joo JE: [A case of desmoid tumor presenting as intra-abdominal abscess]. Korean J Gastroenterol; 2009 May;53(5):315-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of desmoid tumor presenting as intra-abdominal abscess].
  • Desmoid tumor is a rare benign tumor derived from fibrous sheath or musculoaponeurotic structure.
  • The tumor is benign histologically but considered as malignant clinically because it has high propensity on infiltrative growth with local invasion and tendency to recurrence after local excision.
  • Especially, when this tumor happens to be in the intra-abdomen, the prognosis is worse because it can cause intestinal obstruction, ureter obstruction and, fistula formation.
  • It also can invade major vessels in abdomen.
  • This tumor occurs more frequently in patients with familial adenomatous polyposis (FAP), in post-partume women, and at old surgical incision site.
  • We report a rare case of the young male patient who presented with an acute abdomen and underwent laparotomy and was found to have an intra-abdominal desmoid tumor with abscess formation.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Abscess / diagnosis. Adult. Diagnosis, Differential. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19458469.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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23. Chen CB, Chiou YY, Chen CH, Chou YH, Chiang JH, Chang CY: Sonographic and computed tomography findings of intra-abdominal desmoid tumor. J Chin Med Assoc; 2010 Jul;73(7):393-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sonographic and computed tomography findings of intra-abdominal desmoid tumor.
  • Intra-abdominal desmoid tumor is rare and seldom reported in the literature.
  • Here, we present a 29-year-old male who suffered from intra-abdominal desmoid tumor, and describe its imaging findings on ultrasound and abdominal computed tomography.
  • This tumor usually presents as a large homogeneous hypodense solid mass on computed tomography, and demonstrates mild enhancement after contrast medium administration.
  • Although rare, it should be included in the differential diagnosis when a patient presents with a large abdominal mass.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibromatosis, Aggressive / diagnosis. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male

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  • [Copyright] 2010 Elsevier. Published by Elsevier B.V. All rights reserved.
  • (PMID = 20688307.001).
  • [ISSN] 1728-7731
  • [Journal-full-title] Journal of the Chinese Medical Association : JCMA
  • [ISO-abbreviation] J Chin Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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24. Ferenc T, Wroński JW, Kopczyński J, Kulig A, Sidor M, Stalińska L, Dziki A, Sygut J: Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor). Pathol Res Pract; 2009;205(5):311-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor).
  • The aims of this study were to analyze the cadherin/catenin adhesion complex in cells from abdominal and extra-abdominal aggressive fibromatosis tumors, and to estimate the correlation between the expression of the tested proteins and the clinical data of the desmoid patients.
  • Immunohistochemistry was used to examine the expression of the cadherin/catenin adhesion complex: APC protein, alpha-, beta-catenin, and N-cadherin in archival material derived from 15 cases of extra-abdominal desmoid tumor (E-AD) and 20 cases of abdominal (AD) desmoid tumor.
  • In the groups investigated, no statistically significant correlation was found between alpha-catenin, beta-catenin (c), (n) and (c+n) expression, and tumor size (p>0.1).
  • The results regarding beta-catenin expression obtained in our study confirm the previous findings that nuclear accumulation of this protein plays a crucial role in the pathogenesis of aggressive fibromatosis.
  • [MeSH-major] Adenomatous Polyposis Coli Protein / biosynthesis. Cadherins / biosynthesis. Fibromatosis, Aggressive / metabolism. alpha Catenin / biosynthesis. beta Catenin / biosynthesis
  • [MeSH-minor] Adult. Age Factors. Aged. Biomarkers, Tumor / analysis. Female. Gene Expression. Humans. Immunohistochemistry. Male. Young Adult

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  • (PMID = 19124205.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Adenomatous Polyposis Coli Protein; 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / alpha Catenin; 0 / beta Catenin
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25. Soravia C, DeLozier CD, Dobbie Z, Berthod CR, Arrigoni E, Bründler MA, Blouin JL, Foulkes WD, Hutter P: Double frameshift mutations in APC and MSH2 in the same individual. Int J Colorectal Dis; 2006 Jan;21(1):79-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The number of polyps (less than ten) was not typical of polyposis; therefore, the diagnosis of HNPCC was entertained.
  • The tumor tissue showed high-grade instability, and a subsequent, immunohistochemistry showed that neither MSH2 nor MSH6 proteins were expressed in tumor cells.
  • The patient later developed an intra-abdominal desmoid tumor.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Frameshift Mutation. Genes, APC. Genetic Predisposition to Disease. MutS Homolog 2 Protein / genetics
  • [MeSH-minor] Adult. Colectomy. Diagnosis, Differential. Germ-Line Mutation. Humans. Male. Pedigree

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  • [RepublishedFrom] Int J Colorectal Dis. 2005 Sep;20(5):466-470 [15834612.001]
  • (PMID = 16676398.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Corrected and Republished Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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26. Lahat G, Nachmany I, Itzkowitz E, Abu-Abeid S, Barazovsky E, Merimsky O, Klauzner J: Surgery for sporadic abdominal desmoid tumor: is low/no recurrence an achievable goal? Isr Med Assoc J; 2009 Jul;11(7):398-402
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgery for sporadic abdominal desmoid tumor: is low/no recurrence an achievable goal?
  • BACKGROUND: Sporadic abdominal desmoid tumors are rare and data on these tumors as a distinct disease entity are lacking.
  • Previous abdominal surgery, trauma, pregnancy and estrogen intake are considered risk factors.
  • OBJECTIVES: To evaluate outcomes of surgery for this rare disease.
  • METHODS: Since 1995, 16 patients with pathologically confirmed desmoid tumor were operated on in our center.
  • All patients presented with an isolated mass; 7 (50%) originated in the abdominal wall, 6 (37.5%) were retroperitoneal and 3 were (18.8%) mesenteric.
  • CONCLUSIONS: The perception of sporadic abdominal desmoids as tumors with a high recurrence rate (20-70%) is probably incorrect.
  • [MeSH-major] Abdominal Neoplasms / surgery. Fibromatosis, Aggressive / surgery

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  • (PMID = 19911489.001).
  • [ISSN] 1565-1088
  • [Journal-full-title] The Israel Medical Association journal : IMAJ
  • [ISO-abbreviation] Isr. Med. Assoc. J.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Israel
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27. Shindholimath VV, Kumar V, Chumber S, Bhuvnesh, Srivastava A: Mesenteric fibromatosis with involvement of the gastrointestinal tract. Trop Gastroenterol; 2006 Oct-Dec;27(4):177-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric fibromatosis with involvement of the gastrointestinal tract.
  • Primary mesenteric fibromatosis is a rare condition.
  • The aggressive nature of these tumors and the potential for major morbidity secondary to resection makes it a challenging disease for the surgeon.
  • We report a case of mesenteric fibromatosis with involvement of small bowel.
  • [MeSH-major] Duodenal Diseases / etiology. Fibromatosis, Abdominal / complications. Intestinal Fistula / etiology. Mesentery. Peritoneal Neoplasms / complications

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  • (PMID = 17542298.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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28. Tamura K, Tani M, Kinoshita H, Yamaue H: Mesenteric desmoid tumor of the interposed jejunal pouch after total gastrectomy. World J Surg Oncol; 2006;4:27

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric desmoid tumor of the interposed jejunal pouch after total gastrectomy.
  • BACKGROUND: Desmoid tumor is a rare entity, and most desmoid tumors are located in abdominal wall or extra-abdominal tissues.
  • Occurrence of desmoid tumor in mesentry is extremely rare.
  • CASE PRESENTATION: we report a mesenteric desmoid tumor in a 73-years-old woman who had undergone total gastrectomy reconstructed with jejunal pouch interposition for gastric carcinoma.
  • After 1 year, a tumor was originating from mesentery of the interposed jejunal pouch was identified, and the patient underwent resection of the large mass which was found to invade pancreas.
  • Histological examination revealed desmoid tumor.
  • CONCLUSION: Desmoid tumor is rare, and it was difficult for the differential diagnosis of desmoid tumor or recurrent tumor.

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  • (PMID = 16740152.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1481628
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29. Iwasa T, Sadamoto Y, Itaba S, Nasu T, Ihara Y, Misawa T, Nakamura K: [A case of mesenteric desmoid tumor]. Nihon Shokakibyo Gakkai Zasshi; 2007 Jun;104(6):804-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of mesenteric desmoid tumor].
  • Abdominal computed tomography showed a tumor, about 5 cm in diameter at the duodeno-jejunal junction.
  • The preoperative diagnosis was submucosal or mesenteric tumor.
  • The tumor derived from the mesenterium and involved the anal side of the small intestine.
  • The tumor was removed with partial excision of the upper jejunum.
  • The diagnosis of mesenteric desmoid tumor was confirmed, histologically.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Ileus / etiology. Mesentery. Peritoneal Neoplasms / diagnosis

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  • (PMID = 17548947.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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30. Ng TY, Yang MD, Chen YF, Chang CH: Resolution of hydronephrosis due to massive mesenteric fibromatosis using cyclo-oxygenase 2 inhibitors. Urology; 2007 Sep;70(3):591.e3-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resolution of hydronephrosis due to massive mesenteric fibromatosis using cyclo-oxygenase 2 inhibitors.
  • Mesenteric fibromatosis is currently a diagnostic and therapeutic challenge.
  • We report a case of mesenteric fibromatosis in a 29-year-old man with a 2-month history of periumbilical fullness who was discovered to have an abdominal mass with hydronephrosis.
  • To the best of our knowledge, we report the first case of hydronephrosis in a mesenteric fibromatosis with Gardner's syndrome, which was successfully treated with a cyclo-oxygenase 2 inhibitor without surgical removal of the mesenteric fibromatosis.
  • The hydronephrosis and mesenteric fibromatosis improved modestly with long-term celecoxib (200 mg twice daily).
  • [MeSH-minor] Adult. Celecoxib. Gardner Syndrome / diagnosis. Gardner Syndrome / genetics. Humans. Laparotomy. Lithotripsy. Male. Nephrostomy, Percutaneous. Ureteral Calculi / etiology. Ureteral Calculi / therapy

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  • (PMID = 17905129.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors; 0 / Pyrazoles; 0 / Sulfonamides; JCX84Q7J1L / Celecoxib
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31. Bertagnolli MM, Morgan JA, Fletcher CD, Raut CP, Dileo P, Gill RR, Demetri GD, George S: Multimodality treatment of mesenteric desmoid tumours. Eur J Cancer; 2008 Nov;44(16):2404-10
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodality treatment of mesenteric desmoid tumours.
  • BACKGROUND: Desmoid tumours are rare neoplasms characterised by clonal proliferation of myofibroblasts that do not metastasise, but often exhibit an infiltrative pattern and functional impairment.
  • A multidisciplinary treatment plan was developed based on primary disease extent, tumour behaviour and resectability.
  • Patients with stable but unresectable disease were observed without treatment.
  • Patients with resectable disease underwent surgery, and patients with unresectable progressing disease received chemotherapy, most commonly liposomal doxorubicin, followed by surgery if chemotherapy rendered the disease resectable.
  • RESULTS: At a median follow-up of 50.0 months (range 4.6-212), 50 patients (96%) have either no recurrence or radiographically stable disease.
  • CONCLUSION: These data indicate that the extent of disease; tumour behaviour and resectability are the important factors when defining a treatment plan for mesenteric desmoid tumours.
  • A multidisciplinary approach of surgery combined with chemotherapy is an effective and function-sparing strategy for managing this disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fibromatosis, Aggressive / drug therapy. Fibromatosis, Aggressive / surgery. Mesentery. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Fibromatosis, Abdominal / drug therapy. Fibromatosis, Abdominal / surgery. Humans. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome. Vinblastine / administration & dosage. Vinblastine / analogs & derivatives. Young Adult

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  • (PMID = 18706807.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; Q6C979R91Y / vinorelbine
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32. Lath C, Khanna PC, Gadewar SB, Agrawal D: Inoperable aggressive mesenteric fibromatosis with ureteric fistula. Case report and literature review. Eur J Radiol; 2006 Jul;59(1):117-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Inoperable aggressive mesenteric fibromatosis with ureteric fistula. Case report and literature review.
  • The purpose of our report is to illustrate an aggressive case of mesenteric fibromatosis in a 17-year-old girl with a ureteric fistula and to review imaging and pathological features, natural history and treatment options of this disease.
  • Our patient underwent computed tomography that revealed a widespread intra-abdominal mass.
  • Fibromatoses represent a spectrum of uncommon benign conditions characterised by proliferating fibrous tissue.
  • The deep intra-abdominal form of mesenteric fibromatosis (MF), one of the rare subtypes of the 'fibromatoses' or 'desmoid tumours', grows rapidly and may become extensive.
  • Surgery provides good results in limited disease and non-surgical modalities in cases of unresectable and residual disease.
  • [MeSH-major] Fibromatosis, Abdominal / radiography. Fibromatosis, Aggressive / radiography. Mesentery / pathology. Tomography, X-Ray Computed. Ureteral Diseases / radiography. Urinary Fistula / radiography

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  • [ErratumIn] Eur J Radiol. 2006 Dec;60(3):480
  • (PMID = 16464556.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Ireland
  • [Number-of-references] 16
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33. Rajesh A, Sandrasegaran K: Mesenteric desmoid mimicking recurrent testicular cancer. Abdom Imaging; 2005 Nov-Dec;30(6):777-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric desmoid mimicking recurrent testicular cancer.
  • The detection of a solid abdominal mass after surgery for testicular cancer most frequently represents metastatic disease.
  • We report an unusual case of mesenteric desmoid tumor presenting after retroperitoneal lymph node dissection for metastatic testicular cancer.
  • [MeSH-major] Fibromatosis, Aggressive / radiography. Mesentery. Neoplasm Recurrence, Local / radiography. Peritoneal Neoplasms / radiography. Testicular Neoplasms / radiography

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  • (PMID = 16096867.001).
  • [ISSN] 0942-8925
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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34. Ballardini P, Gulmini L, Margutti G, Lelli G: Mesenteric fibromatosis in a patient with Camurati-Engelmann disease. A case report and literature review. Tumori; 2005 Nov-Dec;91(6):552-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric fibromatosis in a patient with Camurati-Engelmann disease. A case report and literature review.
  • Mesenteric fibromatosis is a rare type of desmoid tumor characterized by local aggressiveness and a tendency to relapse.
  • Camurati-Engelmann disease is a very rare form of bone dysplasia characterized by osteosclerosis of the diaphyses of the long bones.
  • Here we describe the case of a male patient affected by these two rare diseases in association with chronic inflammatory intestinal disease.

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  • (PMID = 16457156.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 21
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35. Spiridakis K, Panagiotakis G, Grigoraki M, Kokkinos I, Papadakis T, Kokkinakis T, Kandylakis S: Isolated giant mesenteric fibromatosis (intra-abdominal desmoid tumors). Case report. G Chir; 2008 Oct;29(10):413-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated giant mesenteric fibromatosis (intra-abdominal desmoid tumors). Case report.
  • A rare case of isolated giant mesenteric fibromatosis is presented.
  • The tumor originated from the fibrous mesenteric tissue.
  • The patient underwent laparotomy because of abdominal discomfort and sub-occlusive symptoms due to the giant mass.
  • Differential diagnosis of mesenteric masses is discussed and the Authors also review the literature concerning this rare disease.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Abdominal / surgery. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / surgery. Humans. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18947463.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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36. Ezumi K, Yamamoto H, Takemasa I, Nomura M, Ikeda M, Sekimoto M, Monden M: Dacarbazine-Doxorubicin therapy ameliorated an extremely aggressive mesenteric desmoid tumor associated with familial adenomatous polyposis: report of a case. Jpn J Clin Oncol; 2008 Mar;38(3):222-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Dacarbazine-Doxorubicin therapy ameliorated an extremely aggressive mesenteric desmoid tumor associated with familial adenomatous polyposis: report of a case.
  • After 10 months, we found an intra-abdominal tumor, which grew rapidly to 25 cm in diameter.
  • We performed an emergency operation, which revealed that it was a desmoid tumor derived mainly from colorectal mesenterium.
  • The tumor was removed with three short segments of intestine and the left ureter.
  • A computed tomography (CT) scan done 3 months later showed a 10 cm mesenteric desmoid tumor at the beginning of jejunum, approaching the root of the superior mesenteric artery (SMA).
  • Fortunately, we were able to remove the tumor without injuring the SMA.
  • To our distress, however, another recurrent mesenteric desmoid tumor was discovered in the pelvis one month later, which grew rapidly from 5 cm to 16 cm within 4 months.
  • Finally, when the desmoid occupied the pelvic space, we gave the patient dacarbazine (DTIC) and doxorubicin (DOX).
  • After seven courses, the mesenteric tumor showed an almost complete response (CR).
  • No evidence of further recurrence of mesenteric desmoid has been seen for 4 years.
  • This combination chemotherapy is a promising strategy, even against an extremely aggressive, life-threatening mesenteric desmoid associated with FAP.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dacarbazine / administration & dosage. Doxorubicin / administration & dosage. Fibromatosis, Aggressive / drug therapy. Mesentery. Peritoneal Neoplasms / drug therapy

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  • (PMID = 18304951.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 094ZI81Y45 / Tamoxifen; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; 8A1O1M485B / Imatinib Mesylate
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37. Jung SH, Paik CN, Jung JH, Lee KM, Chung WC, Yang JM: Simultaneous Colonic Obstruction and Hydroureteronephrosis due to Mesenteric Fibromatosis. Gut Liver; 2009 Sep;3(3):215-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Simultaneous Colonic Obstruction and Hydroureteronephrosis due to Mesenteric Fibromatosis.
  • Mesenteric fibromatosis (MF) is a rare benign mesenchymal lesion that can occur throughout the gastrointestinal tract, especially small bowel.
  • We described a patient that presented with colonic obstruction and hydroureteronephrosis due to MF at sigmoid colon which mimicked submucosal tumor such as gastrointestinal tumor.
  • This case resulted in a positive positron emission tomography scan suggesting malignant neoplasm, but beta-catenin positivity on immunohistochemical staining separated MF from gastrointestinal stromal tumor and sclerosing mesenteritis.

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  • [Cites] World J Gastroenterol. 2007 Dec 7;13(45):5985-8 [18023087.001]
  • [Cites] Dis Colon Rectum. 2007 Jun;50(6):924-6 [17205200.001]
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  • [Cites] AJR Am J Roentgenol. 1991 Mar;156(3):539-42 [1899752.001]
  • (PMID = 20431749.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852704
  • [Keywords] NOTNLM ; Colonic obstruction / Hydroureteronephrosis / Mesenteric fibromatosis
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38. Pérez García FJ, Pinto Blazquez J, Rodríguez Martínez JJ, Gutiérrez García R, Jorge Barreiro JI, Velasco Alonso J: [Mesenteric desmoid tumor mimicking a testicular cancer recurrence]. Arch Esp Urol; 2007 Jul-Aug;60(6):703-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mesenteric desmoid tumor mimicking a testicular cancer recurrence].
  • [Transliterated title] Tumor desmoide mesentérico simulando una recidiva de cáncer testicular.
  • OBJECTIVE: Report of one case of desmoid tumor in a patient who had been treated of a testicular seminoma 26 months before, with excision of a retroperitoneal mass and chemotherapy.
  • On followup he presented with a mesenteric abdominal mass which was clinically labeleled as a recurrence of the seminoma.
  • RESULTS: Histologically it was reported as a mesenteric desmoid tumor.
  • Differential diagnosis with gastrointestinal stromal tumor was performed with immunohistochemical studies.
  • CONCLUSIONS: Desmoid tumor is rare.
  • There are few cases reported in patients with history of previous testicular tumor.
  • It should be included in the differential diagnosis of testicular tumor recurrences.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Mesentery. Peritoneal Neoplasms / diagnosis. Seminoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Humans. Male. Neoplasm Recurrence, Local / diagnosis

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  • (PMID = 17847750.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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39. Rampone B, Pedrazzani C, Marrelli D, Pinto E, Roviello F: Updates on abdominal desmoid tumors. World J Gastroenterol; 2007 Dec 7;13(45):5985-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Updates on abdominal desmoid tumors.
  • Desmoid tumor is a monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures.
  • Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons.
  • The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations difficult.
  • [MeSH-major] Fibromatosis, Abdominal / therapy. Neoplasm Recurrence, Local

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  • (PMID = 18023087.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 50
  • [Other-IDs] NLM/ PMC4250878
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40. Huerta S, Heubner DR, Marcus DR: Mesenteric fibromatosis in a young girl without familial adenomatous polyposis. J Pediatr Surg; 2005 May;40(5):e33-6
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  • [Title] Mesenteric fibromatosis in a young girl without familial adenomatous polyposis.
  • Mesenteric fibromatosis (MF) is a rare, benign tumor commonly associated with Gardner's syndrome.
  • Patients may present with abdominal pain or discomfort when the tumors reach large sizes, which is typical at the time of diagnosis.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Omentum / surgery. Peritoneal Diseases / surgery


41. Batori M, Chatelou E, Mariotta G, Sportelli G, Straniero A, Casella G, Casella MC: Giant mesenteric fibromatosis. Eur Rev Med Pharmacol Sci; 2005 Jul-Aug;9(4):223-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mesenteric fibromatosis.
  • Mesenteric fibromatosis is a proliferative fibroblastic neoplasia of the small intestine mesentery which may occur as a unique or multiple formation.
  • Mesenteric fibromatosis represents the 8% of all desmoid neoplasm.
  • Giant mesenteric fibromatosis is uncommon by itself (2-4 case/milion/year).
  • Since the rarity of this tumor and the difficulties in diagnostic and therapeutic ambit, we believe it justified to describe a case of giant mesenteric fibromatosis which came to our observation.

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  • (PMID = 16128042.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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42. Perenze B, Potì O, Margiotta A, Rega D, Marrano N, Minni F: [Mesenteric fibromatosis]. Chir Ital; 2005 Nov-Dec;57(6):717-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mesenteric fibromatosis].
  • [Transliterated title] La fibromatosi mesenterica.
  • Mesenteric fibromatosis is a rare benign mesenteric tumour, characterised by infiltrative growth and high rates of recurrence.
  • Histological examination is the only diagnostic procedure capable of ruling out a malignant mesenteric neoplasm.
  • It is not always possible to perform a radical removal of the tumour mass because it may have infiltrated important anatomical structures.
  • In the present study the Authors report two cases of mesenteric fibromatosis and analyse the main clinical-diagnostic, therapeutic and prognostic problems posed by these tumours.

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  • (PMID = 16400766.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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43. Rosato L, Mondini G, Serbelloni M, Bertone P, Orlassino R, Cossavella D: [Intra-abdominal desmoid tumors: rare but important disease]. G Chir; 2007 Jan-Feb;28(1-2):20-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Intra-abdominal desmoid tumors: rare but important disease].
  • Desmoid tumors are rare benign neoplasms with high tendency to local recurrence, and they can be divided into extra- and intra-abdominal types (mesenteric fibromatosis).
  • Six patients (3 men and 3 women) affected by extra-abdominal desmoid tumors have been treated with radical excision.
  • In two patients desmoid was intra-abdominal:.
  • 1) a 55 years old man admitted for acute abdomen and submitted, in emergency, to a laparotomy with excision of a mesenteric abscess including a jejunal loop at about one meter from Treitz;.
  • 2) 52 years old man, submitted to an elective excision of a capsulated neoplasm of the little omentum, which had caused an oppressive abdominal pain.
  • In both cases the hystological diagnosis has been desmoid tumor.
  • Surgical treatment of desmoid tumors must aim at radical excision to avoid frequent recurrences (25-65%); these have stimulated the research of other kinds of treatments, since a new surgical operation itself can lead to a further recurrence.
  • Radiotherapy has been investigated with results in 79-96% of cases, antiestrogenic therapy has been used with success in 51% of patients, and high dose tamoxifen seemed to obtain a stable disease in non operable cases.
  • Conclusive results on the efficacy of these treatments have not been obtained yet, because of the rarity of the desmoid tumors even in greater Centres.
  • [MeSH-major] Fibromatosis, Abdominal / surgery. Mesentery. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Abdominal Neoplasms / pathology. Abdominal Neoplasms / surgery. Aged. Female. Fibromatosis, Aggressive / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17313728.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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44. Holubar S, Dwivedi AJ, O'Connor J: Giant mesenteric fibromatosis presenting as small bowel obstruction. Am Surg; 2006 May;72(5):427-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mesenteric fibromatosis presenting as small bowel obstruction.
  • Mesenteric fibromatosis is a proliferative fibroblastic neoplasia of the small intestine mesentery that may occur as a unique or multiple formation.
  • Mesenteric fibromatosis is a rare, locally aggressive neoplasm and may present with abdominal discomfort, abdominal pain, weight loss, or symptoms of ureteral obstruction, mesenteric ischemia, or intestinal obstruction.
  • It is of the utmost importance to distinguish mesenteric fibromatosis from gastrointestinal stromal tumors.
  • The involvement of important structures like the superior mesenteric artery and the superior mesenteric vein may pose a challenge during resection, but these tumors can be excised and the vessels repaired primarily.
  • [MeSH-major] Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / diagnosis. Intestinal Obstruction / etiology
  • [MeSH-minor] Diagnosis, Differential. Gastrointestinal Stromal Tumors / pathology. Humans. Male. Mesentery. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16719198.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. McCormack D, Kesha K, Tittle SL, Saldinger PF: Mesenteric fibromatosis mimicking a gastrointestinal stromal tumor. Conn Med; 2010 Apr;74(4):197-200
Genetic Alliance. consumer health - Fibromatosis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric fibromatosis mimicking a gastrointestinal stromal tumor.
  • Mesenteric fibromatosis is a locally aggressive tumor of the mesentery with a high propensity for bowel involvement.
  • Mesenteric fibromatosis often mimics gastrointestinal stromal tumors in size, location and immunohistochemical features.
  • We report the case of a 30-year-old male who underwent resection of a mesenteric tumor, initially diagnosed as gastrointestinal stromal tumor.
  • The tumor was categorized as high-risk and the patient was treated with chemotherapy.
  • The tumor did not respond to medical management.
  • The patient underwent a second en bloc resection and pathology results were conclusive for mesenteric fibromatosis.
  • This case highlights the significance of accurately differentiating mesenteric fibromatosis from gastrointestinal stromal tumor.
  • Making a concrete diagnosis is often difficult because both gastrointestinal stromal tumors and mesenteric fibromatosis share a number of morphological and immunohistochemical features including CKIT expression.
  • [MeSH-major] Diagnostic Errors. Fibromatosis, Abdominal / diagnosis. Gastrointestinal Stromal Tumors / diagnosis
  • [MeSH-minor] Adult. Antineoplastic Agents / therapeutic use. Diagnosis, Differential. Humans. Male

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  • (PMID = 20440999.001).
  • [ISSN] 0010-6178
  • [Journal-full-title] Connecticut medicine
  • [ISO-abbreviation] Conn Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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46. Basu S, Nair N, Banavali S: Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management. Br J Radiol; 2007 Sep;80(957):750-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management.
  • In this preliminary report, we explore the uptake pattern of fluorodeoxyglucose (FDG) in fibromatosis and hypothesize the potential clinical role of FDG-positron emission tomography (PET) in the management of this benign but locally aggressive heterogeneous group of soft-tissue tumours.
  • Five patients were studied (two men and three women, age range 23-35 years), among whom were three cases of deep musculoskeletal fibromatosis, one of abdominal fibromatosis (abdominal desmoid) associated with familial adenomatous polyposis (Gardner's syndrome) and one case of both deep musculoskeletal fibromatosis and abdominal desmoid.
  • The maximum standardized uptake value (SUV(max)) observed was up to 4.7; the avidity probably related to the biological aggressiveness and tendency for recurrence, characteristic of fibromatosis.
  • Hence, a baseline FDG-PET can serve a valuable role in monitoring the effect of systemic pharmacotherapy in patients with recurrent progressive disease after unsuccessful local-regional treatment.
  • The findings in this report can be extrapolated and have implications for studying the utility of FDG-PET in defining aggressiveness, guiding biopsy and defining excision site in a large tumour and in monitoring therapy in fibromatosis.
  • [MeSH-minor] Adult. Female. Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / radiography. Fibromatosis, Abdominal / radionuclide imaging. Gardner Syndrome / complications. Humans. Male. Positron-Emission Tomography. Recurrence. Retrospective Studies

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  • (PMID = 17709361.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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47. Colović R, Grubor N, Radak V, Micev M, Stojković M, Colović N: [Aggressive intraabdominal fibromatosis]. Vojnosanit Pregl; 2006 Sep;63(9):839-42
MedlinePlus Health Information. consumer health - Tumors and Pregnancy.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Aggressive intraabdominal fibromatosis].
  • BACKGROUND: Intraabdominal or mesenteric fibromatosis is a rare benign nonmetastatic neoplasm that appears as a sporadic lesion or in patients with familiar polyposis.
  • CASE REPORT: We presented a 22-year-old woman in whom an aggressive intraabdominal fibromatosis had appeared during the first pregnancy as a well circumscribed ovoid tumor, involving the terminal ileum, the caecum, the ascending colon, the right kidney, the ureter, and the right common iliac artery.
  • The tumor was excised with right colectomy, nephroureterectomy and resection of the involved artery using arterial reconstruction with graft interposition.
  • Two years after the surgery the patient developed an inoperable tumor recurrency with a fatal outcome.
  • CONCLUSION: In spite of a successful surgical excision during the original surgery intraabdominal or mesenteric fibromatosis might have an aggressive evolution leading to an inoperable tumor recurrency and a fatal outcome.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Neoplasm Recurrence, Local. Pregnancy Complications, Neoplastic / pathology

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  • (PMID = 17039898.001).
  • [ISSN] 0042-8450
  • [Journal-full-title] Vojnosanitetski pregled
  • [ISO-abbreviation] Vojnosanit Pregl
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
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48. Choi JY, Kang KM, Kim BS, Kim TH: Mesenteric fibromatosis causing ureteral stenosis. Korean J Urol; 2010 Jul;51(7):501-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric fibromatosis causing ureteral stenosis.
  • Mesenteric fibromatosis is a rare benign disease characterized by proliferating fibrous tissue in the bowel mesentery.
  • We report a case of aggressive mesenteric fibromatosis with ureteral stenosis arising in a 46-year-old woman who suffered from intermittent right abdominal pain.
  • Computed tomography revealed a right retroperitoneal mass with right ureteral stenosis at the level of the right common iliac vessel.
  • Pathological examination confirmed mesenteric fibromatosis.

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  • [Cites] Urology. 2007 Sep;70(3):591.e3-4 [17905129.001]
  • [Cites] Eur J Radiol. 2006 Jul;59(1):117-21 [16464556.001]
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  • (PMID = 20664786.001).
  • [ISSN] 2005-6745
  • [Journal-full-title] Korean journal of urology
  • [ISO-abbreviation] Korean J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2907502
  • [Keywords] NOTNLM ; Aggressive fibromatosis / Retroperitoneal neoplasms
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49. Barrera E, García A, Ferrufino J: [Desmoid tumor: report of a case]. Rev Gastroenterol Peru; 2005 Jul-Sep;25(3):288-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Desmoid tumor: report of a case].
  • [Transliterated title] Tumor desmoide: reporte de un caso.
  • The desmoid tumor is a solid tumor with soft parts and with various possible locations.
  • The diagnosis was made by pathological anatomy.
  • [MeSH-major] Fibromatosis, Abdominal
  • [MeSH-minor] Diagnosis, Differential. Duodenal Obstruction / diagnosis. Duodenal Obstruction / etiology. Duodenal Obstruction / pathology. Duodenal Obstruction / radiography. Duodenal Obstruction / surgery. Duodenum / pathology. Female. Humans. Middle Aged

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  • (PMID = 16237475.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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50. Ramos-Font C, Santiago Chinchilla A, Rebollo Aguirre AC, Rodríguez Fernández A, Medina Benítez A, Llamas Elvira JM: [Desmoid tumor of the thoraco-abdominal wall characterized with 18F-fluorodeoxyglucose PET/ CT scan. Correlation with magnetic resonance and bone scintigraphy. Review of the literature]. Rev Esp Med Nucl; 2009 Mar-Apr;28(2):70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Desmoid tumor of the thoraco-abdominal wall characterized with 18F-fluorodeoxyglucose PET/ CT scan. Correlation with magnetic resonance and bone scintigraphy. Review of the literature].
  • [Transliterated title] Tumor desmoide de la pared torácico-abdominal. Caracterización con PET-TAC con 18F-fluorodesoxiglucosa y correlación con resonancia magnética y gammagrafía ósea. Revisión de la literatura.
  • Desmoid tumours are uncommon benign tumours but with aggressive behaviour, resulting from the proliferation of well-differentiated fibroblasts.
  • When planning treatment, it is important to assess the correct tumour extent to permit curative radical surgery minimizing possible local recurrence.
  • We present the case of a patient with a desmoid tumour of the abdominal-chest wall and we review the related literature.
  • [MeSH-major] Abdominal Neoplasms / radionuclide imaging. Abdominal Wall / radionuclide imaging. Bone Neoplasms / radionuclide imaging. Fibromatosis, Aggressive / radionuclide imaging. Fluorine Radioisotopes. Fluorodeoxyglucose F18. Muscle Neoplasms / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Rectus Abdominis / radionuclide imaging. Ribs / radionuclide imaging. Tomography, X-Ray Computed

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  • (PMID = 19406052.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 22
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51. Dafford K, Kim D, Nelson A, Kline D: Extraabdominal desmoid tumors. Neurosurg Focus; 2007;22(6):E21

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extraabdominal desmoid tumors.
  • OBJECT: Desmoid tumors are fibrous, slow-growing, nonmalignant tumors with a low potential for metastasis.
  • METHODS: The authors undertook a retrospective study of 15 desmoid tumors in 11 women and four men (ranging in age from 32 to 67 years; median 48 years) treated at their institution.
  • There was tumor recurrence in two patients (13%) leading to further surgical intervention.
  • CONCLUSIONS: This case series included many recurrent desmoid tumors of the brachial plexus.
  • Currently, function-sparing excision is considered the optimal treatment for desmoid tumors arising in extraabdominal sites.
  • Adjunctive radiation or brachytherapy is reserved for a patient with further recurrence in whom resection would be disfiguring or in whom the disease is more refractory.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Abdominal / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Retrospective Studies

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  • (PMID = 17613213.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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52. Rajakannu M, Ananthakrishnan N, Madhavan M: Isolated mesenteric fibromatosis. Trop Gastroenterol; 2008 Jul-Sep;29(3):179-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated mesenteric fibromatosis.
  • Fibromatosis is a rare, locally aggressive but non-metastasising fibrous mass often associated with familial adenomatous polyposis in Gardner's Syndrome (GS).
  • Although sporadic cases occur, unlike in GS, they are predominantly extra-abdominal.
  • We report the case of a 40-year-old lady who underwent laparotomy for a large isolated abdominal mass three years after a Whipple's procedure for adenocarcinoma of the distal common bile duct.
  • A spherical, football sized tumour was found in the jejunal mesentery.
  • Resection of the tumour with jejunum was carried out.
  • This case is peculiar in that mesenteric fibromatosis occurred in a patient with prior history of periampullary carcinoma and without history of familial adenomatous polyposis.
  • [MeSH-major] Fibroma / diagnosis. Jejunal Neoplasms / diagnosis

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  • (PMID = 19115615.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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53. Whittle P C, Sánchez R L, Albarracin G J, Hepp K J: [Retroperitoneal fibromatosis: report of a case]. Rev Med Chil; 2006 Jan;134(1):85-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Retroperitoneal fibromatosis: report of a case].
  • [Transliterated title] Fibromatosis mesentérica: caso clínico-imagenológico y revisión bibliográfica.
  • We report a 42 years old female that presented with abdominal pain and no palpable mass.
  • Imaging abdominal ultrasound, CAT scan and magnetic resonance showed a solid tumor located in the retroperitoneum.
  • The patient was operated on excising the tumor.
  • Pathological examination of the surgical piece disclosed a retroperitoneal fibromatosis or desmoid tumor.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 16532167.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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54. Sun L, Wu H, Zhuang YZ, Guan YS: A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us? World J Gastroenterol; 2007 Mar 14;13(10):1632-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us?
  • Mesenteric fibromatosis is a rare benign nonmetastatic neoplasm that appears as a sporadic lesion or occurs in patients with familial polyposis, while chylous ascites associated with aggressive mesenteric fibromatosis during pregnancy has never been reported thus far.
  • Here we present the case of a 28-year old pregnant woman, in whom an aggressive mesenteric fibromatosis with chylous ascites was detected, involving the jejunum, superior mesenteric artery (SMA) and superior mesenteric vein (SMV) and pancreas.
  • The authors report the case for its rarity and emphasize on combining clinicopathological, radiological and immunohistochemistry analysis for management of the disease.
  • [MeSH-major] Chylous Ascites / etiology. Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / diagnosis. Pregnancy Complications / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Mesentery / pathology. Mesentery / radiography. Peritoneal Neoplasms / complications. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology. Pregnancy. Tomography, Spiral Computed

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  • (PMID = 17461463.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4146913
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55. Suresh CS, Ali AA: Desmoid tumor of the tongue. Med Oral Patol Oral Cir Bucal; 2008 Dec;13(12):E761-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor of the tongue.
  • Desmoid tumors are rare neoplasms accounting for 0.03% of all neoplasms and have an estimated incidence of 2 to 4 per million per year.
  • World Health Organization currently refers to all of the deep types of fibromatosis as desmoid-type of fibromatoses.
  • The term "desmoid" refers to the hard, tendon-like appearance of the tumor.
  • About fifty percent of desmoid tumors arise in the abdominal region.
  • The extra-abdominal desmoid tumors present a difficult problem in recognition and management especially because of the striking discrepancy between its deceptively harmless microscopic appearance and its potential to attain a large size, to recur, and to infiltrate neighboring tissues in the manner of a fibrosarcoma.
  • Desmoid tumors are very rare in the oral cavity with less than 5% of cases constituting oral soft tissue fibromatosis.
  • A 22-year old mentally retarded female patient with desmoid tumor occurring in the tongue is presented here.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Tongue Neoplasms / pathology

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  • (PMID = 19047962.001).
  • [ISSN] 1698-6946
  • [Journal-full-title] Medicina oral, patología oral y cirugía bucal
  • [ISO-abbreviation] Med Oral Patol Oral Cir Bucal
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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56. Leal RF, Silva PV, Ayrizono Mde L, Fagundes JJ, Amstalden EM, Coy CS: Desmoid tumor in patients with familial adenomatous polyposis. Arq Gastroenterol; 2010 Oct-Dec;47(4):373-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor in patients with familial adenomatous polyposis.
  • CONTEXT: Desmoid tumors constitute one of the most important extraintestinal manifestations of familial adenomatous polyposis.
  • OBJECTIVES: To evaluate the occurrence of desmoid tumors in familial adenomatous polyposis cases following prophylactic colectomy and to present patient outcome.
  • Desmoid tumors were found in nine (13.2%) of these patients, who were studied retrospectively by consulting their medical charts with respect to clinical and surgical data.
  • RESULTS: Of nine patients, seven (77.8%) were submitted to laparotomy for tumor resection.
  • Desmoid tumors were found in the abdominal wall in 3/9 cases (33.3%) and in an intra-abdominal site in the remaining six cases (66.7%).
  • Median time elapsed between ileal pouch-anal anastomosis and diagnosis of desmoid tumor was 37.5 months (range 14-60 months), while the median time between colectomy with ileorectal anastomosis and diagnosis was 63.7 months (range 25-116 months).
  • In 6/9 (66.7%) patients with desmoid tumors, the disease was either under control or there was no evidence of tumor recurrence at a follow-up visit made a mean of 63.1 months later (range 12-240 months).
  • CONCLUSIONS: Desmoid tumors were found in 13.2% of cases of familial adenomatous polyposis following colectomy; therefore, familial adenomatous polyposis patients should be followed-up and surveillance should include abdominal examination to detect signs and symptoms.
  • [MeSH-major] Abdominal Neoplasms / surgery. Colectomy. Fibromatosis, Abdominal / surgery. Fibromatosis, Aggressive / surgery
  • [MeSH-minor] Abdominal Wall / surgery. Adult. Anastomosis, Surgical. Female. Follow-Up Studies. Humans. Male. Middle Aged. Treatment Outcome. Young Adult


57. Okuno S: The enigma of desmoid tumors. Curr Treat Options Oncol; 2006 Nov;7(6):438-43
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The enigma of desmoid tumors.
  • Desmoid tumors (aggressive fibromatosis) are rare neoplastic tumors that may occur sporadically or in association with familial adenomatous polyposis (FAP).
  • A distinction is often made between desmoids in patients with FAP and those in patients without FAP, but clinically these tumors are treated the same; the only difference is the preferential intra-abdominal location of FAP desmoids.
  • The goal of desmoid treatment is local control.
  • Patients with symptomatic, progressive disease who can tolerate chemotherapy should be presented with the option of low-dose or standard antisarcoma chemotherapy.
  • The treatment of desmoid tumors remains an enigma.
  • Further clinical trials are needed to help the clinician navigate his or her way through the morass of desmoid tumor therapies.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Abdominal / drug therapy

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  • (PMID = 17032556.001).
  • [ISSN] 1527-2729
  • [Journal-full-title] Current treatment options in oncology
  • [ISO-abbreviation] Curr Treat Options Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 094ZI81Y45 / Tamoxifen; 9008-11-1 / Interferons
  • [Number-of-references] 22
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58. Koh PK, Loi C, Cao X, Cheah PY, Ho KS, Ooi BS, Tang CL, Eu KW: Mesenteric desmoid tumors in Singapore familial adenomatous polyposis patients: clinical course and genetic profile in a predominantly Chinese population. Dis Colon Rectum; 2007 Jan;50(1):75-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mesenteric desmoid tumors in Singapore familial adenomatous polyposis patients: clinical course and genetic profile in a predominantly Chinese population.
  • PURPOSE: This study examined the mutational profile of the adenomatous polyposis coli gene in relation to the development of desmoid tumors in familial adenomatous polyposis patients from a predominantly Chinese population.
  • Identification of specific adenomatous polyposis coli gene mutation was performed and clinical course of associated desmoid disease obtained from case records and a computerized database.
  • The clinical course of desmoid tumors can be divided into stable (n=11), variable (n=3), progressive (n=6), and aggressive growth (n=3).
  • Only 3 (13 percent) patients with aggressive tumor growth required chemotherapy.
  • The most common complications related to the mesenteric desmoids were intestinal obstruction (21.7 percent), ureteric obstruction (17.4 percent), and encasement of superior mesenteric vessels (13 percent).
  • CONCLUSION: The clinical course of desmoids in an individual familial adenomatous polyposis patient remains unpredictable and no reliable genetic marker is available for prognostication in desmoid disease.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Fibromatosis, Abdominal / genetics

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  • (PMID = 17082890.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Codon
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59. Kujak JL, Liu PT, Johnson GB, Callstrom MR: Early experience with percutaneous cryoablation of extra-abdominal desmoid tumors. Skeletal Radiol; 2010 Feb;39(2):175-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Early experience with percutaneous cryoablation of extra-abdominal desmoid tumors.
  • OBJECTIVE: Surgical resection, radiation therapy and chemotherapy are all accepted as standard treatments for extra-abdominal desmoid (EAD) tumors, but their effectiveness has been limited by frequent local recurrence.
  • The purpose of this article is to describe our early experiences with using percutaneous cryoablation for local control of extra-abdominal desmoid tumors in five patients whose tumors had failed to respond to standard therapy.
  • Three of these patients had been referred for cryoablation for local tumor control, and two had been referred for palliation of inoperable tumors.
  • RESULTS: For the three patients referred for local control of EAD tumors, complete tumor coverage with the ablation zones was achieved.
  • The third patient, with a 6.1 cm mass, reported improved mild pain at 6 months, and imaging showed a moderate decrease of tumor size.
  • For the two patients referred for palliative therapy, initial partial pain relief was felt 2 weeks after the procedure, At long-term (58 months) follow-up of one patient with a 9.1 cm mass, the tumor was still present although reduced in size, and local pain had returned to its former moderate level.
  • [MeSH-major] Cryosurgery / methods. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / surgery
  • [MeSH-minor] Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / surgery. Adolescent. Adult. Child. Female. Humans. Male. Pilot Projects. Treatment Outcome. Young Adult

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  • (PMID = 19768644.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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60. Singh N, Sharma R, Dorman SA, Dy VC: An unusual presentation of desmoid tumor in the ileum. Am Surg; 2006 Sep;72(9):821-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual presentation of desmoid tumor in the ileum.
  • Desmoid tumors are nonencapsulated, locally invasive tumors of fibrous origin.
  • Intra-abdominal desmoids are commonly found in the mesentery.
  • We present the report of a case in which a sporadic desmoid tumor originated from the wall of the ileum.
  • Of all the options described, surgery with tumor-free margins has been defined as the best treatment modality.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Ileal Neoplasms / diagnosis

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  • (PMID = 16986393.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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61. Amiot A, Dokmak S, Sauvanet A, Vilgrain V, Bringuier PP, Scoazec JY, Sastre X, Ruszniewski P, Bedossa P, Couvelard A: Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion. JOP; 2008;9(3):339-45
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  • [Title] Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion.
  • CONTEXT: Desmoid tumors are rare, benign soft tissue tumors, characterized by the proliferation of fibroblasts in an abundant collagen extra-cellular matrix.
  • Intra-abdominal forms involve the mesentery and retroperitoneum and usually occur associated with familial adenomatous polyposis or Gardner's syndrome.
  • Although desmoid tumors do not metastasize, their evolution can be life-threatening due to aggressive local invasion, such as mesentery involvement.
  • CASE REPORT: We herein report a very rare location of sporadic desmoid tumors involving the pancreatic tail, presenting as a cystic lesion.
  • A 51-year-old woman presented with recurrent abdominal pain and weight loss.
  • The diagnosis of mucinous cystadenocarcinoma was suspected preoperatively and the patient underwent a splenopancreatectomy with en-bloc resection of the left colonic flexure, duodenojejunal junction and part of the posterior gastric wall.
  • Pathological analysis revealed fibroblastic proliferation arising in musculoaponeurotic structures consistent with a desmoid tumor.
  • The diagnosis was confirmed by immunocytochemical analysis and the assessment of the beta-catenin gene mutation.
  • No treatment was given postoperatively to prevent desmoid tumor recurrence.
  • CONCLUSION: Desmoid tumors are very rare in the pancreas and their diagnosis can be difficult, such as in our case where it presented as a cystic lesion.
  • In contrast to intra-abdominal forms, sporadic pancreatic desmoid tumors are more frequent than those associated with familial adenomatous polyposis.
  • [MeSH-major] Fibromatosis, Abdominal / etiology. Pancreatic Cyst / complications
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Female. Humans. Middle Aged

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  • (PMID = 18469451.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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62. Leithner A, Gapp M, Radl R, Pascher A, Krippl P, Leithner K, Windhager R, Beham A: Immunohistochemical analysis of desmoid tumours. J Clin Pathol; 2005 Nov;58(11):1152-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical analysis of desmoid tumours.
  • BACKGROUND/AIMS: Although the standard treatment for desmoid tumours is complete surgical resection with wide margins, the optimal adjuvant treatment for recurrent or inoperable disease is unclear, often being based on sporadic immunohistochemical reports with a low number of cases.
  • METHODS: One hundred and sixteen tissue samples from 80 patients (49 female, 31 male; mean age, 34 years; range, 0-83) with desmoid tumours (46 extra-abdominal, 21 abdominal, 13 intra-abdominal) were tested for oestrogen receptors alpha and beta, progesterone and androgen receptors, and somatostatin, in addition to HER2, cathepsin D, Ki-67, and c-KIT by immunohistochemistry.
  • Positive staining for the androgen receptor was found in six extra-abdominal cases.
  • Staining for oestrogen receptor beta was positive in four extra-abdominal, two abdominal, and one intra-abdominal case.
  • Staining for somatostatin was positive in six extra-abdominal, two abdominal, and one intra-abdominal case, and staining for cathepsin D was positive in all cases.
  • Positive staining for Ki-67 was found in 14 extra-abdominal, three abdominal, and three intra-abdominal cases.
  • C-KIT was detectable in one abdominal case only.
  • CONCLUSIONS: The data from this immunohistochemical study show that the published effects of antioestrogens and imatinib mesylate in the treatment of aggressive fibromatoses may not be attributable to oestrogen receptor alpha or c-KIT expression.
  • [MeSH-major] Biomarkers, Tumor / analysis. Fibromatosis, Aggressive / metabolism. Soft Tissue Neoplasms / chemistry
  • [MeSH-minor] Abdominal Neoplasms / chemistry. Abdominal Neoplasms / drug therapy. Abdominal Neoplasms / pathology. Adolescent. Adult. Aged. Aged, 80 and over. Cathepsin D / analysis. Chemotherapy, Adjuvant. Child. Child, Preschool. Female. Humans. Infant. Infant, Newborn. Ki-67 Antigen / analysis. Male. Middle Aged. Neoplasm Proteins / analysis. Proto-Oncogene Proteins c-kit / analysis. Receptors, Androgen / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Somatostatin / analysis

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  • [Cites] Cancer. 2002 Dec 1;95(11):2373-9 [12436445.001]
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  • (PMID = 16254103.001).
  • [ISSN] 0021-9746
  • [Journal-full-title] Journal of clinical pathology
  • [ISO-abbreviation] J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone; 51110-01-1 / Somatostatin; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 3.4.23.5 / Cathepsin D
  • [Other-IDs] NLM/ PMC1770757
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63. Bethune R, Amin A: Mesenteric fibromatosis: a rare cause of acute abdominal pain. Ann R Coll Surg Engl; 2006 Mar;88(2):1-2
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  • [Title] Mesenteric fibromatosis: a rare cause of acute abdominal pain.
  • A 45-year-old man, with a previous history of astrocytoma, presented with diffuse abdominal pain.
  • A CT scan was non-specific and the pain worsened; his abdomen became peritonitic on examination.
  • An exploratory laparotomy was performed, and a large small bowel mesenteric mass was found together with an associated haematoma.
  • Subsequent histology showed the tumour to be a benign fibromatosis, and the patient recovered uneventfully.
  • There were no reports in the literature of any association between astrocytomas and fibromatosis.
  • Mesenteric fibromatosis is a rare tumour often associated with Gardner's syndrome.
  • [MeSH-major] Abdominal Pain / etiology. Fibroma / complications. Ileal Diseases / complications. Mesentery
  • [MeSH-minor] Acute Disease. Astrocytoma / complications. Colonic Diseases / complications. Diagnosis, Differential. Gastrointestinal Hemorrhage / complications. Hematoma / complications. Humans. Male. Middle Aged

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  • (PMID = 16884606.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 5
  • [Other-IDs] NLM/ PMC1963641
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64. Church J, Lynch C, Neary P, LaGuardia L, Elayi E: A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis. Dis Colon Rectum; 2008 Jun;51(6):897-901
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis.
  • PURPOSE: Intra-abdominal desmoid tumors associated with familial adenomatous polyposis are heterogeneous.
  • Eight patients with Stage I disease received medical treatment, as did 26 with Stage II, 16 with Stage III, and 15 with Stage IV.
  • Chemotherapy was given to 1 Stage II tumor, 7 Stage III, and 5 Stage IV.
  • No patient with Stages I or II disease died.
  • Finally 89 percent with Stage I, 65 percent with Stage II, 59 percent with Stage III, and 50 percent with Stage IV disease were asymptomatic; 81 percent of Stage I desmoids, 78 percent of Stage II, 42 percent of Stage III, and 28 percent of Stage IV were stable or disappeared.
  • CONCLUSION: Desmoid staging identifies tumors by prognosis and its use for designing prospective treatment studies is reasonable.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Neoplasm Staging / methods

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  • (PMID = 18322756.001).
  • [ISSN] 1530-0358
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. Ioannou M, Demertzis N, Iakovidou I, Kottakis S: The role of imatinib mesylate in adjuvant therapy of extra-abdominal desmoid tumors. Anticancer Res; 2007 Mar-Apr;27(2):1143-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of imatinib mesylate in adjuvant therapy of extra-abdominal desmoid tumors.
  • BACKGROUND: Extra-abdominal desmoid tumors are rare neoplasms with variable biological behavior.
  • The purpose of this study was to determine the possible presence of tyrosine-kinase receptors in extra-abdominal desmoid tumors as a marker for imatinib mesylate therapy.
  • PATIENTS AND METHODS: From 1999 to 2004, immunohistochemical methods were carried-out in 14 patients with histologically confirmed extra-abdominal desmoid tumors to determine c-KIT positivity (existence of tyrosine-kinase receptors and PDGFRA and PDGFRB).
  • RESULTS: All desmoid tumors were c-KIT negative, which demonstrates absence of tyrosine-kinase receptors.
  • CONCLUSION: The histological c-KIT markup is an easy and reliable method that can detect whether a desmoid tumor is sensitive to additional treatment with a tyrosine-kinase receptor inhibitor.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Fibromatosis, Aggressive / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 17465254.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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66. Michopoulou A, Germanos S, Kanakopoulos D, Milonas A, Orfanos N, Spyratou C, Markidis P: Management of a large abdominal wall desmoid tumor during pregnancy. Case report. Ann Ital Chir; 2010 Mar-Apr;81(2):153-6
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  • [Title] Management of a large abdominal wall desmoid tumor during pregnancy. Case report.
  • Desmoid tumors, characterized by aggressive local infiltration of surrounding tissues, are uncommon benign neoplasms with no metastatic potential, that occasionally may attain large size.
  • We report a case of a 37-year-old woman with an abdominal wall desmoid tumor that appeared and grew rapidly during her pregnancy, diagnosed by trucut core biopsy.
  • Complete surgical excision of a 20 x 16 cm in size tumor and immediate reconstruction with mesh was performed in the postpartum period.
  • Optimal management of large abdominal wall desmoids during pregnancy has to be individualized, with wide surgical excision remaining the treatment of choice.
  • [MeSH-major] Abdominal Wall. Fibromatosis, Aggressive / surgery. Pregnancy Complications, Neoplastic / surgery

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  • (PMID = 20726395.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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67. Stoidis CN, Spyropoulos BG, Misiakos EP, Fountzilas CK, Paraskeva PP, Fotiadis CI: Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report. J Med Case Rep; 2010;4:314

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report.
  • INTRODUCTION: Intra-abdominal fibromatosis, usually located at the mesenteric level, is a locally invasive tumor of fibrous origin, with no ability to metastasize, but a tendency to recur.
  • Certain non-typical cases of intra-abdominal fibromatosis with involvement of the bowel wall can be misdiagnosed because of their different biological behavior.
  • CASE PRESENTATION: We describe the case of a 64-year-old Caucasian man presenting with mesenteric fibromatosis and involvement of the bowel wall, who was treated surgically.
  • The macroscopic and microscopic appearance of the lesion mimicked a gastrointestinal stromal tumor, a tumor with potential malignant behavior.
  • CONCLUSION: It is essential to make an early and correct diagnosis in such equivocal cases, so that the appropriate treatment can be chosen and suitable patients admitted to clinical trials if appropriate.
  • New and reliable criteria for discriminating between intra-abdominal fibromatosis and gastrointestinal stromal tumor should be proposed and established because novel sophisticated therapeutic strategies have been introduced in the international literature.

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  • (PMID = 20863383.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2955058
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68. Schlager A, Altchek A, Kalir T, Deligdisch L, Weber KJ: Mesenteric fibromatosis masquerading as an ovarian neoplasm twenty years after Chernobyl radiation exposure. Gynecol Oncol; 2006 Sep;102(3):587-9
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  • [Title] Mesenteric fibromatosis masquerading as an ovarian neoplasm twenty years after Chernobyl radiation exposure.
  • BACKGROUND: Since their initial description in 1832, desmoid tumors have been reported to occur in virtually every part of the body.
  • Intra-abdominal desmoid tumors, or mesenteric fibromatosis, are often associated with Familial Adenomatous Polyposis mutation in a syndrome known as Gardner's Syndrome.
  • Although sporadic cases of desmoid tumors do occur, unlike Gardner's Syndrome, they predominantly occur extra-abdominally.
  • CASE: Case report of a 61-year-old female who presented with two months of abdominal pain, progressive lower abdominal distension and a 10-15 pound weight gain accompanied by one week of urinary hesitancy and frequency.
  • Patient underwent a diagnostic workup for an ovarian neoplasm, but was found at surgery to have mesentric fibromatosis.
  • CONCLUSION: Although uncommon, mesentric fibromatosis must be considered in the differential diagnosis when evaluating a patient with an abdominal mass of unknown origin.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Aggressive / diagnosis. Ovarian Neoplasms / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Power Plants. Radioactive Hazard Release. Ukraine

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  • (PMID = 16678243.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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69. Dalal AK, Singal R, Dalal U, Attri AK, Sahu P, Gupta A: An unusual case of chest wall desmoid tumor. Indian J Surg; 2010 Jul;72(Suppl 1):336-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual case of chest wall desmoid tumor.
  • Desmoid tumor of the chest wall are uncommon fibromatous tumors characterized by their local invasion and frequent recurrences.
  • Extra-abdominal sites are mainly the shoulder girdle, the pelvic girdle and distal ends of the lower limbs.
  • The chest wall represents 8-10% of cases and the tumor is exceptionally intrathoracic.
  • We present here a rare case of a large desmoid tumor of left antero-lateral chest wall.
  • In the presented case, wide excision of the tumor and chest wall reconstruction was done.

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  • (PMID = 23133290.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451859
  • [Keywords] NOTNLM ; Chest wall / Extra abdominal tumor / Surgery
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70. de Bree E, Keus R, Melissas J, Tsiftsis D, van Coevorden F: Desmoid tumors: need for an individualized approach. Expert Rev Anticancer Ther; 2009 Apr;9(4):525-35
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  • [Title] Desmoid tumors: need for an individualized approach.
  • Desmoid tumor, also known as aggressive fibromatosis or desmoid-type fibromatosis, is a rare monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures.
  • Since it is a heterogeneous disease, in particular regarding clinical presentation, anatomic location and biological behavior, treatment should be individualized to reduce local tumor control failure with concurrently acceptable morbidity and preservation of quality of life.
  • Radiotherapy for gross disease is considerably effective, but is associated with a relatively high rate of complications, which are usually mild or moderate and radiation dose dependent.
  • Risk factors for local tumor control failure include young age, large size, presentation as recurrent disease, limb/girdle or intra-abdominal location, involved surgical margins, omission of radiotherapy, radiation dose less than 50 Gy and insufficient radiation field size.
  • Considering the significant morbidity of surgery and/or radiotherapy for certain locations, especially mutilation and loss of function, and the tumor's natural history, which is often characterized by prolonged periods of stability or even regression, a period of watchful waiting may compose the most appropriate management in selected asymptomatic patients.
  • Attempts to complete eradication of the disease may be worse than the disease itself.
  • [MeSH-major] Fibromatosis, Aggressive / therapy

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  • (PMID = 19374605.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors
  • [Number-of-references] 89
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71. Ridders J, Ernst A, Todt I, Seidl RO: [Extra-abdominal desmoid tumors. Case report and literature review]. HNO; 2005 Jul;53(7):639-44
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  • [Title] [Extra-abdominal desmoid tumors. Case report and literature review].
  • [Transliterated title] Extraabdominelle Fibromatose. Fallbericht und Literaturübersicht.
  • Musculoaponeurotic fibromatosis or desmoid tumors are rare.
  • We report the case of a 57 year old woman with a slowly growing tumor behind the sternocleidomastoid muscle, which was completely removed.
  • Histological examination confirmed the clinical suspicion of a desmoid tumor.
  • Desmoid tumors are aggressive, locally infiltrating, non-metastasizing tumors with a high local recurrence.
  • The diagnosis is made histologically, reactive fibromatosis and fibrosarcoma must be eliminated in differential diagnosis.
  • Adjuvant therapy, such as x-ray treatment, chemo- and hormone therapy, are indicated when the tumor is inoperable or too extensive for surgery.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Head and Neck Neoplasms / diagnosis
  • [MeSH-minor] Abdominal Neoplasms / diagnosis. Abdominal Neoplasms / pathology. Abdominal Neoplasms / surgery. Adult. Calcinosis / diagnosis. Calcinosis / pathology. Calcinosis / surgery. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Neck Muscles / pathology. Neck Muscles / surgery. Tomography, X-Ray Computed. Ultrasonography

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  • (PMID = 15257395.001).
  • [ISSN] 0017-6192
  • [Journal-full-title] HNO
  • [ISO-abbreviation] HNO
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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72. Privette A, Fenton SJ, Mone MC, Kennedy AM, Nelson EW: Desmoid tumor: a case of mistaken identity. Breast J; 2005 Jan-Feb;11(1):60-4
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  • [Title] Desmoid tumor: a case of mistaken identity.
  • Desmoid tumors are rare tumors accounting for only 0.03% of all neoplasms.
  • Mainly occurring in the fourth and fifth decades of life, these tumors originate in musculoaponeurotic tissues of the limbs, neck, trunk, abdominal wall, and mesentery.
  • We present a rare case of a chest wall desmoid tumor that was mistaken for breast cancer on both physical examination and mammography, which highlights the unique risk these tumors present for confusion with other malignant processes.
  • Although past literature contains numerous reports of other misdiagnoses, this case is unique in reporting the potential for misdiagnosis between chest wall desmoid tumors and breast cancer.
  • In cases where suspicious breast findings do not correlate to usual diagnostic measures, such as fine-needle aspiration or core needle biopsy, the possibility of another pathology such as a chest wall desmoid tumor mimicking breast cancer should be considered in the differential diagnosis.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Thoracic Neoplasms / diagnosis. Thoracic Wall
  • [MeSH-minor] Aged. Biopsy, Needle. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms / surgery. Breast Neoplasms / ultrasonography. Diagnosis, Differential. Female. Humans. Mammography. Mastectomy. Tomography, X-Ray Computed

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  • (PMID = 15647081.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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73. Yang JL, Wang J, Zhou XY, Li XQ, Hou YY, Zhu XZ: [Clinicopathologic and genetic studies of desmoid-type fibromatosis]. Zhonghua Bing Li Xue Za Zhi; 2006 Mar;35(3):145-50
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  • [Title] [Clinicopathologic and genetic studies of desmoid-type fibromatosis].
  • OBJECTIVE: To study the clinicopathological and genetic features of desmoid-type fibromatosis, and to investigate the feasibility of detecting trisomy 8 in formalin fixed, paraffin embedded (FFPE) tissue by fluorescence in-situ hybridization (FISH).
  • Histopathologic and immunohistochemical evaluations were available in 69 cases, and ultrastructural evaluation was done in 2 cases of desmoid-type fibromatosis.
  • Clinically, there were 44 extra-abdominal tumors, 28 abdominal wall tumors and 23 intra-abdominal lesions mostly involving the mesentery.
  • Histologically, desmoid-type fibromatoses showed longitudinal fascicles of spindle fibroblasts and myofibroblasts in a predominantly collagenous background.
  • The tumor cells stained positive for vimentin, alpha-smooth muscle actin, desmin, and beta-catenin (47.8%, 33/69).
  • Ultrastructurally, most tumor cells had features of fibroblasts, including rich endoplasmic reticulum and Golgi apparatus.
  • Some tumor cells were myofibroblast-like cells exhibiting intercellular junctions, fibronexous junctions and stress fibers.
  • Trisomy 8 was detected in 6 of 20 cases of desmoid-type fibromatosis including 5 of the 8 recurrent tumors but only one of the 12 primary tumors.
  • The latter tumor also recurred three years later.
  • CONCLUSIONS: Desmoid-type fibromatosis is an intermediate (locally aggressive) tumor that occurs predominantly in young females.
  • Trisomy 8 can be detected in FFPE tissue by FISH, and its presence serves as a useful predictor of tumor recurrence and may define a subtype of desmoid-type fibromatosis with high recurrence rate.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Peritoneal Neoplasms / pathology. Trisomy

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  • (PMID = 16630502.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / Vimentin; 0 / beta Catenin
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74. Fimmanò A, Coppola Bottazzi E, Cirillo C, Tammaro P, Casazza D: [Desmoid tumor of the chest wall foiling surgery]. Ann Ital Chir; 2006 Mar-Apr;77(2):169-72; discussion 172
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  • [Title] [Desmoid tumor of the chest wall foiling surgery].
  • [Transliterated title] Desmoide della parete toracica, ad insorgenza postchirurgica.
  • The anatomo-pathological test showed a desmoid fibromatosis (desmoid tumor) extra-abdominal (12.5 x 9 x 5 cm).
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Thoracic Wall

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  • (PMID = 17147093.001).
  • [ISSN] 0003-469X
  • [Journal-full-title] Annali italiani di chirurgia
  • [ISO-abbreviation] Ann Ital Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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75. Johner A, Tiwari P, Zetler P, Wiseman SM: Abdominal wall desmoid tumors associated with pregnancy: current concepts. Expert Rev Anticancer Ther; 2009 Nov;9(11):1675-82
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  • [Title] Abdominal wall desmoid tumors associated with pregnancy: current concepts.
  • The desmoid tumors (DTs) are unusual soft-tissue tumors that have a propensity for aggressive local growth and may develop during, or soon after pregnancy.
  • Pregnancy-associated DTs are uncommon and optimal management of this tumor has yet to be defined.
  • Currently, controversy centers on the timing of surgical resection and is influenced by the potential for tumor growth and the effects of a gravid uterus.
  • [MeSH-major] Abdominal Wall / surgery. Fibromatosis, Aggressive / surgery. Pregnancy Complications, Neoplastic / surgery

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  • (PMID = 19895250.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 78
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76. Seinfeld J, Kleinschmidt-DeMasters BK, Tayal S, Lillehei KO: Desmoid-type fibromatosis involving the brachial plexus. Neurosurg Focus; 2007;22(6):E22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid-type fibromatosis involving the brachial plexus.
  • Desmoid-type fibromatosis involving the brachial plexus is a rare and challenging disease.
  • The authors describe their experience in four surgically treated patients with desmoid-type fibromatosis involving the brachial plexus and review the relevant neurosurgical literature.
  • Three patients experienced tumor recurrence requiring reoperation.
  • Fractionated radiotherapy achieved local control in three patients, and the disease in one patient progressed beyond the treatment field.
  • One tumor with this mutation did not respond to treatment with imatimib mesylate.
  • Analysis of these cases emphasizes the need for careful resection in patients with desmoid-type fibromatosis and supports the conclusion that without adjuvant radiotherapy a high local recurrence rate can be anticipated.
  • For optimal local disease control, the authors recommend postsurgical radiation therapy regardless of the extent of resection achieved.
  • [MeSH-major] Brachial Plexus / pathology. Brachial Plexus / surgery. Fibromatosis, Abdominal / radiotherapy. Fibromatosis, Abdominal / surgery
  • [MeSH-minor] Adult. Aged. Female. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / radiotherapy. Fibromatosis, Aggressive / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17613214.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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77. Ferenc T, Stalińska L, Turant M, Sygut J, Tosik D, Dziki A, Kulig A: Analysis of TGF-beta protein expression in aggressive fibromatosis (desmoid tumor). Pol J Pathol; 2006;57(2):77-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of TGF-beta protein expression in aggressive fibromatosis (desmoid tumor).
  • Aggressive fibromatosis, usually termed desmoid tumor, develops from muscle connective tissue, fasciae and aponeuroses.
  • Aggressive fibromatosis located in various parts of the body demonstrates differentiated biological behavior.
  • Abnormalities in TGF-beta expression are very common in many disease processes, including neoplasms.
  • Immunohistochemical analysis employing a monoclonal antibody against TGF-beta was performed on archival material, consisting of 38 cases of aggressive fibromatosis, among which 23 represented abdominal, 11 extra-abdominal and 4 intra-abdominal localizations.
  • The average percentage of cells positively stained for TGF-beta protein was 40.2% in the group of extra-abdominal, 58.5% in the group of abdominal and 72.8% in the group of intra-abdominal localizations.
  • There were significant differences observed between the analyzed groups of desmoid tumor (p<0.05).
  • A positive cytoplasmic reaction for TGF-beta was noted in 65.8% (25/38) of the aggressive fibromatoses.
  • Overexpression of TGF-beta protein was noted in 39.5% (15/38) of the aggressive fibromatoses.
  • High expression noticed in desmoid fibroblasts might indicate that this protein plays a crucial role in the development of aggressive fibromatosis.
  • [MeSH-major] Abdominal Neoplasms / metabolism. Fibromatosis, Aggressive / metabolism. Transforming Growth Factor beta / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Count. Cytoplasm / metabolism. Cytoplasm / pathology. Fibroblasts / metabolism. Fibroblasts / pathology. Humans. Image Processing, Computer-Assisted. Immunoenzyme Techniques

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  • (PMID = 17019969.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transforming Growth Factor beta
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78. de Camargo VP, Keohan ML, D'Adamo DR, Antonescu CR, Brennan MF, Singer S, Ahn LS, Maki RG: Clinical outcomes of systemic therapy for patients with deep fibromatosis (desmoid tumor). Cancer; 2010 May 1;116(9):2258-65
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical outcomes of systemic therapy for patients with deep fibromatosis (desmoid tumor).
  • BACKGROUND: In the current study, the authors examined the outcomes of patients with desmoid tumors who received systemic therapy at a single institution to provide a basis for the examination of newer agents.
  • METHODS: Records of patients with desmoid tumors who were treated with chemotherapy at the study institution were reviewed.
  • Patients without measurable disease and those receiving therapy could not be documented, and those receiving prophylactic therapy were excluded.
  • At the time of last follow-up, 9 patients had died, 7 of progressive disease.
  • An intra-abdominal primary tumor location was the most common (44%).
  • On multivariate analysis, macroscopic nodular morphology and the presence of Gardner syndrome were the only tumor factors found to be associated with a greater time to disease progression.
  • CONCLUSIONS: Compared with other agents, antiestrogens and anthracycline-containing regimens appear to be associated with a higher radiological response rate against desmoid tumors.
  • Systemic therapy can be successful in patients with desmoid tumors, and is a viable option in lieu of morbid or disabling surgery.

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  • [Copyright] (c) 2010 American Cancer Society.
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  • (PMID = 20187095.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / RC2 CA148260-01; United States / NCI NIH HHS / CA / P01 CA47179; United States / NCI NIH HHS / CA / P01 CA047179-15A2; United States / CCR NIH HHS / RC / CA148260-01; United States / NCI NIH HHS / CA / P01 CA047179
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ NIHMS219553; NLM/ PMC2925106
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79. Maseelall P, Robins JC, Williams DB, Thomas MA: Stabilization and regression of a recurrent desmoid tumor with the antiestrogen toremifene. Fertil Steril; 2005 Aug;84(2):509
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stabilization and regression of a recurrent desmoid tumor with the antiestrogen toremifene.
  • OBJECTIVE: To report a case of a pelvic desmoid tumor that was treated with the antiestrogen toremifene after a failed attempt at surgical excision.
  • PATIENT(S): A reproductive-aged woman with a recurrent desmoid tumor.
  • INTERVENTION(S): After surgical excision of a desmoid tumor that presented during childbirth, subsequent recurrence resulted in the use of toremifene for tumor stabilization.
  • MAIN OUTCOME MEASURE(S): Magnetic resonance imaging was used to monitor desmoid tumor size.
  • RESULT(S): One year after postsurgical recurrence of the desmoid tumor, the patient began treatment with the antiestrogen toremifene.
  • Tumor stabilization and regression with symptomatic relief was observed.
  • Nine years of antiestrogen use revealed no progression in tumor size or patient symptoms.
  • After the patient demonstrated perimenopausal symptoms, toremifene administration was discontinued without a return of symptoms or tumor growth after 3 years.
  • CONCLUSION(S): Our case demonstrates that toremifene is a safe and effective therapy that can be used for the stabilization and regression of desmoid tumors.
  • An antiestrogen should be considered as adjuvant therapy after surgery and as a first-line treatment with disease recurrence.
  • [MeSH-major] Estrogen Antagonists / therapeutic use. Fibromatosis, Abdominal / drug therapy. Fibromatosis, Aggressive / drug therapy. Neoplasm Recurrence, Local / prevention & control. Toremifene / therapeutic use

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  • (PMID = 16086575.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Antagonists; 7NFE54O27T / Toremifene
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80. Ferenc T, Sygut J, Tosik D, Kopczyński J, Sidor M, Góźdź S, Kulig A, Dziki A, Turant M, Stalińska L: Analysis of p27KIP1 protein and Ki-67 expression in aggressive fibromatosis (desmoid tumor). Pol J Pathol; 2006;57(4):187-91
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  • [Title] Analysis of p27KIP1 protein and Ki-67 expression in aggressive fibromatosis (desmoid tumor).
  • Aggressive fibromatosis (desmoid tumor) is an uncommon locally invasive non-metastasizing neoplasm lesion.
  • Desmoid tumor consists of fibroblasts, miofibroblasts and a significant amount of extracellular matrix. p27KIP1 (p27) protein is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family that regulates progression through the cell cycle.
  • There were analysed 42 specimens of aggressive fibromatosis, in which there were 24 abdominal and 18 extra-abdominal cases.
  • There was no statistically significant difference between Ki-67 or p27 expression in abdominal and extra-abdominal location.
  • Analysis of p27 and Ki-67 expression levels might indicate that low proliferating activity of desmoid fibroblasts is connected with another mechanism than the one, in which p27 takes part.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Fibromatosis, Abdominal / metabolism. Ki-67 Antigen / metabolism

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  • (PMID = 17285761.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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81. Tiwari A, Topno M, Karim T, Sharma V: A rare case of desmoid tumor of thigh. Indian J Surg; 2010 Oct;72(5):409-11
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  • [Title] A rare case of desmoid tumor of thigh.
  • Extraabdominal desmoid tumor is a locally aggressive tumor despite being histologically benign.
  • To avoid local recurrence, it is important to preoperatively detect the exact localization and extension of the infiltrating or disseminating lesion in this tumor.
  • We report a case of recurrent extraabdominal desmoid tumor, which arose in the posterior thigh region.
  • On investigation he was found to be case of desmoid tumor of thigh.

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  • [Cites] J Radiol. 2002 Jun;83(6 Pt 1):711-6 [12149587.001]
  • [Cites] Cancer. 1954 Sep;7(5):953-78 [13199773.001]
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  • [Cites] J Bone Joint Surg Am. 1996 Jun;78(6):848-54 [8666602.001]
  • (PMID = 21966144.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3077143
  • [Keywords] NOTNLM ; Extra abdominal desmoid / Surgical excision / Thigh swelling
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82. Liao CM, Chang WC, Ko KH, Kao HW, Cheng MF, Huang GS, Wu CJ: Desmoid tumor arising in the site of previous surgery in the left lower quadrant of the abdomen. South Med J; 2010 Feb;103(2):162-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor arising in the site of previous surgery in the left lower quadrant of the abdomen.
  • A desmoid tumor is a fibroblastic proliferation arising in musculoaponeurotic structures.
  • A 79-year-old woman who developed a desmoid tumor in the left lower abdomen after surgical resection of an abdominal lipoma seven years previously is presented.
  • Preoperative computed tomography showed a large left lower abdominal mass.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Neoplasms, Second Primary / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans

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  • (PMID = 20175252.001).
  • [ISSN] 1541-8243
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Basdanis G, Papadopoulos VN, Panidis S, Tzeveleki I, Karamanlis E, Mekras A, Apostolidis S, Michalopoulos A: Desmoid tumor of mesentery in familial adenomatous polyposis: a case report. Tech Coloproctol; 2010 Nov;14 Suppl 1:S61-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor of mesentery in familial adenomatous polyposis: a case report.
  • While a mass in the left lateral abdominal region was palpated.
  • Pathological examination revealed a desmoid tumor of the mesentery.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Fibromatosis, Aggressive / surgery. Neoplasms, Second Primary / surgery. Peritoneal Neoplasms / surgery

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  • [Cites] Ann Surg Oncol. 2008 Sep;15(9):2439-50 [18612695.001]
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  • (PMID = 20683751.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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84. Stalinska L, Turant M, Tosik D, Sygut J, Kulig A, Kopczynski J, Dziki A, Ferenc T: Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor). Histol Histopathol; 2009 03;24(3):299-308
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor).
  • Aggressive fibromatosis (desmoid tumor) is a mesenchymal lesion originating from fascial, aponeurotic and muscular connective tissue.
  • In this study we analyzed the cell cycle regulation proteins: pRb, p16, and proliferating antigens: Ki-67, PCNA, MCM5 with immunohistochemical method in archival material derived from 27 extra-abdominal (E-AD), 18 abdominal (AD) and 5 intra-abdominal (I-AD) cases of desmoid tumor.
  • None of the examined cases (n=50) of aggressive fibromatosis was pRb-immunonegative.
  • The noted levels of pRb and p16 expression in desmoid cells reflect their function in cell cycle regulation.
  • Probably the unsettled cell cycle progression, especially in G1 phase, is not the cause of aggressive fibromatosis pathogenesis.
  • [MeSH-major] Cell Cycle Proteins / analysis. Cyclin-Dependent Kinase Inhibitor p16 / analysis. Fibromatosis, Abdominal / metabolism. Ki-67 Antigen / analysis. Proliferating Cell Nuclear Antigen / analysis. Retinoblastoma Protein / analysis

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  • (PMID = 19130399.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Ki-67 Antigen; 0 / MCM5 protein, human; 0 / Proliferating Cell Nuclear Antigen; 0 / Retinoblastoma Protein
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85. Rifaat MA, Abdel Gawad WS: The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation. J Egypt Natl Canc Inst; 2005 Sep;17(3):139-48
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  • [Title] The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation.
  • As a pedicled flap its reach to the lower abdomen and groin made it an attractive option for reconstructing soft tissue defects after tumor ablation.
  • Also, the adequacy of the fascia lata as a sole substitute for abdominal wall muscles has been disputable.
  • PATIENTS AND METHODS: From April 2001 to April 2004, 12 pedicled TFL flaps were used to reconstruct 5 central abdominal wall full thickness defects and 6 groin soft tissue defects following tumor resection.
  • In one case, bilateral flaps were used to reconstruct a large central abdominal wall defect.
  • From the abdominal wall defects group, all repairs were enforced primarily with a prolene mesh except for one patient who was the first in this study.
  • Patients presenting with groin defects required coverage of exposed vessels following tumor resection.
  • RESULTS: The resulting soft tissue defects in this study were due to resection of 4 abdominal wall desmoid tumors, a colonic carcinoma infiltrating the abdominal wall, 4 primary groin soft tissue sarcomas, a metastatic SCC of the leg to groin nodes, and a primary SCC of the groin.
  • Three of those cases developed in flaps reconstructing abdominal wall defects, and one case developed in a flap used to cover a groin defect.
  • Out of the 5 cases that underwent abdominal wall reconstruction, one case developed ventral hernia, in which bilateral TFL flaps were used without mesh enforcement.
  • Only one patient died of distant metastasis of a SCC of the groin skin, 8 months postoperatively and another 2 patients with abdominal desmoid tumors developed local recurrence.
  • A pedicled flap would be appropriate for lower abdominal wall defects, and is better islanded to achieve extra mobilization and allow a tension free closure, while for groin defects, simple flap transposition should be enough.
  • Nevertheless, reconstruction for full thickness abdominal wall defects by this flap is a static reconstruction.
  • [MeSH-major] Abdominal Wall / surgery. Groin / surgery. Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Abdominal Neoplasms / surgery. Adult. Fascia Lata. Female. Humans. Male. Middle Aged. Reconstructive Surgical Procedures

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  • (PMID = 16799651.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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86. Bertani E, Chiappa A, Testori A, Mazzarol G, Biffi R, Martella S, Pace U, Soteldo J, Vigna PD, Lembo R, Andreoni B: Desmoid tumors of the anterior abdominal wall: results from a monocentric surgical experience and review of the literature. Ann Surg Oncol; 2009 Jun;16(6):1642-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumors of the anterior abdominal wall: results from a monocentric surgical experience and review of the literature.
  • BACKGROUND: Desmoid tumor, also known as aggressive fibromatosis, is a rare soft tissue tumor.
  • For those cases localized in the anterior abdominal wall, radical resection and reconstruction with a mesh is indicated.
  • Because the rarity of the disease, randomized trials are lacking, but in reported retrospective series, it is clear that although it is considered a benign lesion, local recurrence is not uncommon.
  • METHODS: We analyzed the records of 14 consecutive patients (3 men, 11 women, mean age 36 years, range 25-51 years) with desmoid tumor of the anterior abdominal wall treated at the European Institute of Oncology.
  • The surgical strategy was the same in all cases: wide surgical excision and immediate plastic reconstruction with mesh after intraoperative confirmation by frozen sections of disease-free margins of >1 cm.
  • CONCLUSIONS: Radical resection aided by intraoperative margin evaluation via frozen sections followed by immediate mesh reconstruction is a safe procedure and can provide definitive cure without functional limitations for patients with desmoid tumors of the anterior abdominal wall.
  • [MeSH-major] Fibromatosis, Aggressive / surgery. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Abdominal Wall. Adult. Female. Humans. Male. Middle Aged. Surgical Mesh

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  • (PMID = 19296178.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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87. Kadoch V, Bodin F, Himy S, Bollecker V, Wilk A, Bruant-Rodier C: Latissimus dorsi free flap for reconstruction of extensive full-thickness abdominal wall defect. A case of desmoid tumor. J Visc Surg; 2010 Apr;147(2):e45-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Latissimus dorsi free flap for reconstruction of extensive full-thickness abdominal wall defect. A case of desmoid tumor.
  • Desmoid tumor is a rare, benign fibroblastic tumor that is characterized by highly aggressive local invasiveness.
  • The authors report the case of a 35-year-old male who presented with a 20 cm para-umbilical tumor invading the right rectus abdominis muscle.
  • This required a wide excision of the abdominal wall.

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • [Cites] Ann Chir Plast Esthet. 1999 Aug;44(4):373-83 [10550916.001]
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  • [Cites] Ann Plast Surg. 1990 Sep;25(3):193-6 [2146916.001]
  • (PMID = 20692637.001).
  • [ISSN] 1878-7886
  • [Journal-full-title] Journal of visceral surgery
  • [ISO-abbreviation] J Visc Surg
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY015928-01; United States / NCRR NIH HHS / RR / RR001315-255511; United States / NEI NIH HHS / EY / F31 EY015928-01; United States / NCRR NIH HHS / RR / P41 RR001315-255511
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Other-IDs] NLM/ NIHMS218152; NLM/ PMC2924994
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88. Ishizuka M, Hatori M, Dohi O, Suzuki T, Miki Y, Tazawa C, Sasano H, Kokubun S: Expression profiles of sex steroid receptors in desmoid tumors. Tohoku J Exp Med; 2006 Nov;210(3):189-98
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression profiles of sex steroid receptors in desmoid tumors.
  • Desmoid tumors are benign fibrous neoplasms which arise from the fibrous tissue of intra- and extra- abdominal sites, but their clinical management is sometimes difficult because of extensive infiltration into the surrounding tissues.
  • Desmoid tumors commonly occur in women, especially after childbirth.
  • Recently, both clinical and experimental findings indicate the possible roles of sex steroids in the development and progression of desmoid tumors but detailed information is still ambiguous.
  • In this study, we first examined immunoreactivity of sex steroid receptors in desmoid tumors (27 cases) by immunohistochemistry and compared the findings with those in reactive self-limiting lesions associated with fibrosis (8 cases).
  • Estrogen receptor (ER) alpha and ERbeta immunoreactivities were detected in 7.4% (2/27) and 7.4% (2/27) of desmoid tumors, respectively.
  • One desmoid tumor expressed both ERalpha and ERbeta.
  • Sex steroid receptor mRNAs was further examined by reverse transcription and polymerase chain reaction (RT-PCR) analysis using fresh frozen tissues, demonstrating the expression of PR (PR-A and/or PR-B) and AR mRNAs in eight desmoid tumors examined and all cases of reactive fibrosis.
  • These results indicate that sex steroid hormones might play an important role in the pathogenesis of desmoid tumors and could lead to the introduction of novel hormone therapeutic approaches in managing patients with recurrent desmoid tumors.
  • [MeSH-major] Fibromatosis, Aggressive / metabolism. Gene Expression Regulation, Neoplastic. Neoplasms / metabolism. Receptors, Steroid / metabolism

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  • (PMID = 17077595.001).
  • [ISSN] 0040-8727
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Receptors, Progesterone; 0 / Receptors, Steroid
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89. Shah M, Azam B: Case report of an intra-abdominal desmoid tumour presenting with bowel perforation. Mcgill J Med; 2007 Jul;10(2):90-2

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Case report of an intra-abdominal desmoid tumour presenting with bowel perforation.
  • Desmoid tumours are benign tumours originating from the musculoaponeurotic structures of the body.
  • Here we present a case report of a young gentleman who presented with an acute surgical abdomen and subsequently underwent a laparotomy and was found to have an inflammatory mass.
  • Histological analysis of this mass revealed mesenteric fibromatosis (desmoid tumour).
  • It is rare for mesenteric fibromatosis to present with intestinal perforation and only one case been reported in the literature thus far (1).

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  • [Cites] Front Radiat Ther Oncol. 2001;35:107-19 [11351941.001]
  • [Cites] Arch Pathol. 1961 Feb;71:214-21 [13706852.001]
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  • (PMID = 18523540.001).
  • [ISSN] 1201-026X
  • [Journal-full-title] McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students
  • [ISO-abbreviation] Mcgill J Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2323473
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90. Speake D, Evans DG, Lalloo F, Scott NA, Hill J: Desmoid tumours in patients with familial adenomatous polyposis and desmoid region adenomatous polyposis coli mutations. Br J Surg; 2007 Aug;94(8):1009-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumours in patients with familial adenomatous polyposis and desmoid region adenomatous polyposis coli mutations.
  • BACKGROUND: :The aim of this study was to determine the proportion of patients with familial adenomatous polyposis (FAP) who had mutations in the desmoid region of the adenomatous polyposis coli (APC) gene that phenotypically expresses desmoid disease, and to determine the role for surgery in these patients.
  • RESULTS: Of 363 patients with FAP, 47 from ten families had APC mutations in the desmoid region 3' to codon 1399.
  • Of 22 patients undergoing surgery, 16 developed desmoids, and of these 12 had mesenteric desmoid disease.
  • Complications from mesenteric desmoids were death (two patients), enterectomy (three), local resection (three), fistula (one), cholangitis and local resection (one), bowel obstruction (one) and bowel and ureteric obstruction (one).
  • CONCLUSION: In individuals with 3' APC mutations, abdominal surgery is associated with a 65 per cent risk of developing mesenteric desmoids.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Fibromatosis, Aggressive / genetics. Genes, APC. Mesentery. Mutation / genetics. Peritoneal Neoplasms / genetics

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  • [Copyright] Copyright (c) 2007 British Journal of Surgery Society Ltd.
  • (PMID = 17410559.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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91. Oguz M, Bedirli A, Gultekin A, Dursun A, Mentes BB: Desmoid tumor arising at the colostomy site after abdominoperineal resection for rectal carcinoma: report of a case. Dis Colon Rectum; 2006 Sep;49(9):1445-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor arising at the colostomy site after abdominoperineal resection for rectal carcinoma: report of a case.
  • A 69-year-old male who developed a desmoid tumor at the site of his end colostomy after abdominoperineal resection for rectal carcinoma is reported.
  • The tumor was resected with wide margins.
  • Histopathology revealed desmoid tumor of the anterior abdominal wall with no malignant features.
  • To our knowledge, this is the first case of solitary desmoid tumor of anterior abdominal wall at the colostomy site reported in the literature.
  • [MeSH-major] Abdominal Wall. Colostomy. Fibromatosis, Aggressive / pathology. Muscle Neoplasms / pathology. Neoplasms, Second Primary / pathology. Rectal Neoplasms / surgery

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  • (PMID = 16897327.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Joyner DE, Trang SH, Damron TA, Aboulafia AJ, Cummings JE, Randall RL: Desmoid cell motility is induced in vitro by rhEGF. J Orthop Res; 2009 Sep;27(9):1258-62
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid cell motility is induced in vitro by rhEGF.
  • Desmoid tumors are benign but locally invasive myofibroblastic lesions that arise predominantly in the abdominal wall or shoulder and are prone to aggressive local recurrences.
  • A perceived association between desmoid activity and the expression of growth factors during pregnancy or following trauma suggests a cause-and-effect relationship between growth factor stimulation and desmoid invasiveness.
  • We used Boyden Chambers to quantify cell motility in order to determine the effect of growth factor stimulation on desmoid cell migration.
  • Desmoid cell cultures were treated under serum-free conditions with epidermal growth factor (rhEGF) or transforming growth factor alpha (rhTGFalpha).
  • The experiments demonstrated a direct dose-dependent relationship between rhEGF stimulation and desmoid motility.
  • [MeSH-major] Cell Movement / drug effects. Epidermal Growth Factor / pharmacology. Fibromatosis, Aggressive / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Antigens, CD29 / genetics. Benzamides / pharmacology. Cell Division / drug effects. Cell Line, Tumor. Culture Media, Serum-Free / pharmacology. Dioxoles / pharmacology. Enzyme Inhibitors / pharmacology. Gene Expression Regulation, Neoplastic. Humans. In Vitro Techniques. Matrix Metalloproteinase 1 / genetics. Matrix Metalloproteinase 3 / genetics. Quinazolines. RNA, Messenger / metabolism. RNA, Small Interfering. Receptor, Epidermal Growth Factor / genetics. Receptors, Transforming Growth Factor beta / antagonists & inhibitors. Recombinant Proteins / pharmacology. STAT3 Transcription Factor / genetics. Transforming Growth Factor alpha / genetics. Transforming Growth Factor alpha / pharmacology. Tyrphostins / pharmacology

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  • [Copyright] (c) 2009 Orthopaedic Research Society.
  • (PMID = 19242968.001).
  • [ISSN] 1554-527X
  • [Journal-full-title] Journal of orthopaedic research : official publication of the Orthopaedic Research Society
  • [ISO-abbreviation] J. Orthop. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide; 0 / Antigens, CD29; 0 / Benzamides; 0 / Culture Media, Serum-Free; 0 / Dioxoles; 0 / Enzyme Inhibitors; 0 / Quinazolines; 0 / RNA, Messenger; 0 / RNA, Small Interfering; 0 / Receptors, Transforming Growth Factor beta; 0 / Recombinant Proteins; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human; 0 / Transforming Growth Factor alpha; 0 / Tyrphostins; 170449-18-0 / tyrphostin AG 1478; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.7 / Matrix Metalloproteinase 1
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93. Tkachev SI, Aliev MD, Glebovskaia VV, Ivanov SM, Trofimova OP, Karapetian RM, Gutnik RA, Bokhian AIu: [Thermoradiotherapy as a component of desmoid tumor management: 10-year experience]. Vopr Onkol; 2005;51(3):347-9
Genetic Alliance. consumer health - Desmoid Tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Thermoradiotherapy as a component of desmoid tumor management: 10-year experience].
  • Data on radio- and thermoradiotherapy of 83 patients with extra-abdominal desmoid tumors are discussed.
  • Monitoring tumor temperature during local hyperthermia is a factor of relapse-free survival of vital importance.
  • [MeSH-major] Fibromatosis, Aggressive / radiotherapy. Hyperthermia, Induced
  • [MeSH-minor] Disease-Free Survival. Follow-Up Studies. Humans. Radiotherapy / methods. Treatment Outcome

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  • (PMID = 16279100.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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94. Barbier O, Anract P, Pluot E, Larouserie F, Sailhan F, Babinet A, Tomeno B: Primary or recurring extra-abdominal desmoid fibromatosis: assessment of treatment by observation only. Orthop Traumatol Surg Res; 2010 Dec;96(8):884-9
Genetic Alliance. consumer health - Fibromatosis.

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  • [Title] Primary or recurring extra-abdominal desmoid fibromatosis: assessment of treatment by observation only.
  • INTRODUCTION: Extra-abdominal desmoid fibromatosis (EADF) is a benign tumoral condition, classically managed by more or less radical and sometimes mutilating excision.
  • One primary tumor showed spontaneous regression, and one recurrence still showed evolution at end of follow-up (23 months).
  • [MeSH-major] Fibroma / therapy. Fibromatosis, Aggressive / therapy. Neoplasm Recurrence, Local / therapy. Soft Tissue Neoplasms / therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Disease Progression. Female. Humans. Kaplan-Meier Estimate. Magnetic Resonance Imaging. Male. Middle Aged. Observation. Retrospective Studies. Young Adult

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  • [Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 21075698.001).
  • [ISSN] 1877-0568
  • [Journal-full-title] Orthopaedics & traumatology, surgery & research : OTSR
  • [ISO-abbreviation] Orthop Traumatol Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
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95. Joyner DE, Trang SH, Aboulafia AJ, Damron TA, Randall RL: FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin. Fam Cancer; 2009;8(4):569-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin.
  • Desmoid tumors are locally invasive myofibroblastic lesions that arise predominantly in the abdominal wall or shoulder girdle and are prone to aggressive local recurrences without metastases.
  • We hypothesized the intrinsic invasiveness and drug resistance displayed by cells derived from a familial adenomatous polyposis (FAP)-associated desmoid tumor would surpass the response shown by cells derived from sporadic desmoid tumors.
  • FAP-associated tumor cells were significantly more invasive and refractory to doxorubicin than were cells extracted from sporadic tumors.
  • Pro-MMP1 protein predominated over MMP3 in FAP-associated cell culture supernatants, while MMP3 was the dominant antigen in sporadic tumor cell supernatants.
  • Three genes associated with apoptosis were identified by microarray, two prosurvival genes overexpressed in FAP-associated cell cultures (NTN1, TNFRSF10C) and one proapoptosis gene overexpressed in sporadic tumor cell cultures (FOXL2).
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Antineoplastic Agents / pharmacology. Doxorubicin / pharmacology. Drug Resistance, Neoplasm / genetics. Fibromatosis, Aggressive / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Adolescent. Adult. Apoptosis / genetics. Cell Line, Tumor. Enzyme-Linked Immunosorbent Assay. Female. Gene Expression / drug effects. Humans. Male. Matrix Metalloproteinase 1 / metabolism. Matrix Metalloproteinase 3 / metabolism. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • [ErratumIn] Fam Cancer. 2010 Jun;9(2):261. Randall, R Lor [corrected to Randall, R L]
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  • (PMID = 19728161.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30CA042014
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.7 / Matrix Metalloproteinase 1
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96. Picariello L, Carbonell Sala S, Martineti V, Gozzini A, Aragona P, Tognarini I, Paglierani M, Nesi G, Brandi ML, Tonelli F: A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells. Anal Biochem; 2006 Jul 15;354(2):205-12
Genetic Alliance. consumer health - Desmoid Tumor.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells.
  • These tumors may be sporadic or associated with a genetic disease such as familial adenomatous polyposis (FAP).
  • Although surgery is widely accepted as the first-line treatment for extra-abdominal and abdominal wall desmoids, a proportion of cases are successfully palliated with either estrogen antagonists (tamoxifen, toremifene, and raloxifene) or nonsteroidal anti-inflammatory drugs.
  • We describe and compare four methods for evaluating the expression of estrogen receptors alpha/beta and COX-1 and COX-2 in desmoid tumor-derived cells and tissues: immunocytochemistry, immunohistochemistry, RT-PCR, and two-color Western blot detection with the Odyssey infrared imaging system.
  • Through this comparative analysis, Western blot with Odyssey was recognized as the best method to analyze the expression particularly of low expressed proteins in desmoid-derived cells.
  • [MeSH-major] Fibromatosis, Aggressive / metabolism. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism
  • [MeSH-minor] Base Sequence. Blotting, Western. Cyclooxygenase 1 / analysis. Cyclooxygenase 1 / genetics. Cyclooxygenase 1 / metabolism. Cyclooxygenase 2 / analysis. Cyclooxygenase 2 / genetics. Cyclooxygenase 2 / metabolism. Estrogen Receptor alpha / analysis. Estrogen Receptor alpha / genetics. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / analysis. Estrogen Receptor beta / genetics. Estrogen Receptor beta / metabolism. Gene Expression. Humans. Immunohistochemistry. Membrane Proteins / analysis. Membrane Proteins / genetics. Membrane Proteins / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 16729958.001).
  • [ISSN] 0003-2697
  • [Journal-full-title] Analytical biochemistry
  • [ISO-abbreviation] Anal. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS1 protein, human; EC 1.14.99.1 / PTGS2 protein, human
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97. Dalén BP, Geijer M, Kvist H, Bergh PM, Gunterberg BU: Clinical and imaging observations of desmoid tumors left without treatment. Acta Orthop; 2006 Dec;77(6):932-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Clinical and imaging observations of desmoid tumors left without treatment.
  • BACKGROUND: Until now, surgical treatment has been the mainstay in the treatment of desmoid tumors, even though it is associated with a high recurrence rate.
  • There have, however, been occasional case reports showing that desmoid tumors may spontaneously decrease in size or even disappear.
  • PATIENTS AND METHODS: This is a retrospective review of 8 patients with abdominal (5) or extra-abdominal (3) desmoid tumors who were followed both clinically and with imaging techniques (sonography, CT or MRI).
  • Tumor volume was assessed in each investigation and followed over time.
  • INTERPRETATION: Desmoid tumors have probably been overtreated in the past.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Aggressive / diagnosis. Neoplasm Regression, Spontaneous. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17260204.001).
  • [ISSN] 1745-3674
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
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98. Levy AD, Rimola J, Mehrotra AK, Sobin LH: From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation. Radiographics; 2006 Jan-Feb;26(1):245-64
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Mesenteric fibromatosis, sclerosing mesenteritis, inflammatory pseudotumor, and extrapleural solitary fibrous tumor constitute a loosely associated group of benign fibrous tumors and tumorlike lesions of the mesentery.
  • Mesenteric fibromatosis is a locally aggressive, benign proliferative process that may occur sporadically or in association with familial adenomatous polyposis.
  • It most frequently manifests as a focal mesenteric mass and may simulate lymphoma, metastatic disease, or a soft-tissue sarcoma.
  • Sclerosing mesenteritis is a rare idiopathic disorder that most commonly produces a stellate mass within the mesentery and should be differentiated from metastatic disease, specifically metastatic carcinoid, because it frequently responds to conservative or medical management.
  • Inflammatory pseudotumor (inflammatory myofibroblastic tumor) is a benign, chronic inflammatory disorder of unknown cause that manifests as a solid mesenteric mass, indistinguishable from malignancy.
  • Extrapleural solitary fibrous tumor is a tumor of submesothelial origin that is identical to the solitary fibrous tumor of the pleura.
  • When located in the mesentery or peritoneal cavity, extrapleural solitary fibrous tumor has an imaging pattern that must be differentiated from metastatic disease, soft-tissue sarcomas, and other benign and malignant neoplasms of the mesentery and peritoneum.
  • Knowledge of this group of benign fibrous tumors and tumorlike lesions of the mesentery is important in the preoperative evaluation of a mesenteric mass.
  • [MeSH-major] Mesentery. Peritoneal Diseases / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Female. Fibroma / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Panniculitis, Peritoneal / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16418255.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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99. Fallen T, Wilson M, Morlan B, Lindor NM: Desmoid tumors -- a characterization of patients seen at Mayo Clinic 1976-1999. Fam Cancer; 2006;5(2):191-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumors -- a characterization of patients seen at Mayo Clinic 1976-1999.
  • Desmoid tumors occur with high frequency in individuals with Familial Adenomatous Polyposis (FAP).
  • Because of this, individuals developing desmoid tumors may be referred for genetic risk assessment.
  • Determining whether a person has a FAP-related desmoid tumor or a sporadic desmoid can be challenging.
  • We sought to characterize the patients who were seen at our institution to determine if there were clinical differences in presentation between FAP-associated and sporadic desmoid tumors.
  • We searched the Mayo Clinic-modified H-ICDA (Hospital adaptation of the International Classification of Diseases) diagnostic codes for all diagnoses of desmoid tumors in patients seen between 1976 and 1999.
  • Charts were reviewed to determine accuracy of diagnosis, age when seen, gender, site of tumor, and presence of polyposis.
  • Location of development of desmoid tumors was correlated with but not specific for distinguishing FAP from non-FAP desmoids.
  • Abdominal desmoids comprised the majority of FAP desmoids and extra-abdominal desmoids comprised the majority of non-FAP desmoids (P<0.001) but age was not a discriminating factor.
  • Using Bayesian analysis, we demonstrate how these findings can assist genetic professionals in their evaluation of patients with desmoid tumors by providing prior probabilities of FAP based upon clinical presentation.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Fibromatosis, Aggressive / genetics

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  • (PMID = 16736290.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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100. Bölke E, Krasniqi H, Lammering G, Engers R, Matuschek C, Gripp S, Gerber PA, Fischer G, Peiper M, Shaikh S, Budach W, Orth K: Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature. Eur J Med Res; 2009 Jun 18;14(6):240-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature.
  • Desmoid tumors are fibroblastic/myofibroblastic neoplasms, which originate from musculo-aponeurotic structures and are classified as deep fibromatoses.
  • Despite their benign histologic appearance and lack of metastatic potential, desmoid tumors may cause aggres?sive local infiltrations and compression of surrounding structures.
  • Radical tumor resection with free margins remains the first therapy of choice.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Thoracic Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 19541583.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 31
  • [Other-IDs] NLM/ PMC3352015
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