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1. Basu S, Nair N, Banavali S: Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management. Br J Radiol; 2007 Sep;80(957):750-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management.
  • In this preliminary report, we explore the uptake pattern of fluorodeoxyglucose (FDG) in fibromatosis and hypothesize the potential clinical role of FDG-positron emission tomography (PET) in the management of this benign but locally aggressive heterogeneous group of soft-tissue tumours.
  • Five patients were studied (two men and three women, age range 23-35 years), among whom were three cases of deep musculoskeletal fibromatosis, one of abdominal fibromatosis (abdominal desmoid) associated with familial adenomatous polyposis (Gardner's syndrome) and one case of both deep musculoskeletal fibromatosis and abdominal desmoid.
  • The maximum standardized uptake value (SUV(max)) observed was up to 4.7; the avidity probably related to the biological aggressiveness and tendency for recurrence, characteristic of fibromatosis.
  • Hence, a baseline FDG-PET can serve a valuable role in monitoring the effect of systemic pharmacotherapy in patients with recurrent progressive disease after unsuccessful local-regional treatment.
  • The findings in this report can be extrapolated and have implications for studying the utility of FDG-PET in defining aggressiveness, guiding biopsy and defining excision site in a large tumour and in monitoring therapy in fibromatosis.
  • [MeSH-minor] Adult. Female. Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / radiography. Fibromatosis, Abdominal / radionuclide imaging. Gardner Syndrome / complications. Humans. Male. Positron-Emission Tomography. Recurrence. Retrospective Studies

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  • (PMID = 17709361.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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2. Venkat D, Levine E, Wise WE: Abdominal pain and colonic obstruction from an intra-abdominal desmoid tumor. Gastroenterol Hepatol (N Y); 2010 Oct;6(10):662-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abdominal pain and colonic obstruction from an intra-abdominal desmoid tumor.

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  • (PMID = 21103447.001).
  • [ISSN] 1554-7914
  • [Journal-full-title] Gastroenterology & hepatology
  • [ISO-abbreviation] Gastroenterol Hepatol (N Y)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2978418
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3. Tan CH, Pua U, Liau KH, Lee HY: Mesenteric desmoid tumour masquerading as a fat-containing cystic mass. Br J Radiol; 2010 Oct;83(994):e200-3
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  • [Title] Mesenteric desmoid tumour masquerading as a fat-containing cystic mass.
  • Mesenteric desmoid tumour (MDT) is an uncommon neoplasm that typically presents as a solid soft-tissue mass on cross-sectional imaging.
  • [MeSH-major] Cysts / radiography. Fibromatosis, Abdominal / radiography. Mesenteric Cyst / radiography
  • [MeSH-minor] Abdominal Pain / etiology. Diagnosis, Differential. Female. Humans. Middle Aged. Tomography, X-Ray Computed. Vomiting / etiology

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  • (PMID = 20846976.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3473748
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4. Pakos EE, Tsekeris PG, Goussia AC: Desmoid tumours of the extremities and trunk: a review of the literature. Int Orthop; 2005 Aug;29(4):210-3
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  • [Title] Desmoid tumours of the extremities and trunk: a review of the literature.
  • Desmoid tumours are rare neoplasms that display local aggressiveness but no propensity to metastasise.
  • They are mainly localized in the abdominal wall, the bowel, and the mesentery or in extra-abdominal sites such as the trunk and the extremities.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / surgery. Soft Tissue Neoplasms / diagnosis. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Abdomen. Back. Extremities. Humans. Prognosis

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  • (PMID = 15900438.001).
  • [ISSN] 0341-2695
  • [Journal-full-title] International orthopaedics
  • [ISO-abbreviation] Int Orthop
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 24
  • [Other-IDs] NLM/ PMC3474525
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5. Kumar V, Khanna S, Khanna AK, Khanna R: Desmoid tumors: experience of 32 cases and review of the literature. Indian J Cancer; 2009 Jan-Mar;46(1):34-9
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  • [Title] Desmoid tumors: experience of 32 cases and review of the literature.
  • AIM: Present study aimed at reporting the 10-year experience of 32 desmoid cases and reviewing some facts with symptoms, investigation, and treatment of the disease.
  • MATERIALS AND METHODS: Thirty two cases of desmoid tumors were reviewed over a 10-year span.
  • The commonest site of presentation was the abdominal wall.
  • CONCLUSIONS: In our experience, 25% of the desmoid tumors (8/32) were recurrent and postoperative radiotherapy did not seem to influence the local recurrence rate.
  • [MeSH-major] Fibromatosis, Aggressive / radiotherapy. Fibromatosis, Aggressive / surgery. Neoplasm Recurrence, Local / diagnosis. Neoplasm, Residual / diagnosis

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  • (PMID = 19282564.001).
  • [ISSN] 0019-509X
  • [Journal-full-title] Indian journal of cancer
  • [ISO-abbreviation] Indian J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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6. Holubar S, Dwivedi AJ, O'Connor J: Giant mesenteric fibromatosis presenting as small bowel obstruction. Am Surg; 2006 May;72(5):427-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mesenteric fibromatosis presenting as small bowel obstruction.
  • Mesenteric fibromatosis is a proliferative fibroblastic neoplasia of the small intestine mesentery that may occur as a unique or multiple formation.
  • Mesenteric fibromatosis is a rare, locally aggressive neoplasm and may present with abdominal discomfort, abdominal pain, weight loss, or symptoms of ureteral obstruction, mesenteric ischemia, or intestinal obstruction.
  • It is of the utmost importance to distinguish mesenteric fibromatosis from gastrointestinal stromal tumors.
  • The involvement of important structures like the superior mesenteric artery and the superior mesenteric vein may pose a challenge during resection, but these tumors can be excised and the vessels repaired primarily.
  • [MeSH-major] Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / diagnosis. Intestinal Obstruction / etiology
  • [MeSH-minor] Diagnosis, Differential. Gastrointestinal Stromal Tumors / pathology. Humans. Male. Mesentery. Middle Aged. Neoplasm Invasiveness

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  • (PMID = 16719198.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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7. Lefevre JH, Parc Y, Kernéis S, Goasguen N, Benis M, Parc R, Tiret E: Risk factors for development of desmoid tumours in familial adenomatous polyposis. Br J Surg; 2008 Sep;95(9):1136-9
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  • [Title] Risk factors for development of desmoid tumours in familial adenomatous polyposis.
  • BACKGROUND: Desmoid tumours (DTs) are the primary cause of death of patients with familial adenomatous polyposis (FAP) following restorative proctocolectomy.
  • DT sites were mesenteric (73 tumours), abdominal wall (44) and extra-abdominal (seven).
  • CONCLUSION: No risk factor for life-threatening mesenteric DT could meaningfully modify the management of patients with FAP.
  • [MeSH-major] Abdominal Neoplasms / etiology. Adenomatous Polyposis Coli / complications. Fibromatosis, Abdominal / etiology. Fibromatosis, Aggressive / etiology. Proctocolectomy, Restorative


8. Giuliani A, Demoro M, Ciardi A, Scimó M, Galati F, Lonardo MT, Galati G: Mesenteric fibromatosis. Case report. J Exp Clin Cancer Res; 2007 Sep;26(3):425-8
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  • [Title] Mesenteric fibromatosis. Case report.
  • Deep fibromatosis is a rare locally aggressive but not metastasizing proliferation.
  • Intra-abdominal fibromatosis (IAF) occurs either in association with Gardner's syndrome or as a sporadic event and presents in most cases differential diagnostic problems with myofibroblastic or fibroblastic tumors, characterized by a more aggressive biological behaviour such as gastrointestinal stromal tumors (GISTs).
  • In absence of loco-regional and/or distant metastasis differential diagnosis may be difficult and represents a topical issue, since it influences treatment choice.
  • We describe the case of a patient with sporadic IAF in which the tumor locally involved the mesentery and presented no loco-regional and distant spread.
  • Definitive diagnosis was made, postoperatively, on the basis of immunohistochemical findings.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibroma / diagnosis. Mesentery
  • [MeSH-minor] Diagnosis, Differential. Gardner Syndrome / pathology. Humans. Male. Middle Aged

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  • (PMID = 17987807.001).
  • [ISSN] 0392-9078
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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9. Dar'ialova SL, Boĭko AV, Novikova OV, Bychkova NM: [The enigma of desmoid fibroma]. Vopr Onkol; 2006;52(4):472-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [The enigma of desmoid fibroma].
  • [MeSH-major] Antineoplastic Agents, Hormonal / therapeutic use. Fibroma, Desmoplastic. Fibromatosis, Aggressive
  • [MeSH-minor] Abdominal Neoplasms / drug therapy. Adolescent. Adult. Buserelin / therapeutic use. Child. Child, Preschool. Female. Follow-Up Studies. Goserelin / therapeutic use. Humans. Infant. Male. Middle Aged. Tamoxifen / therapeutic use. Treatment Outcome

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  • (PMID = 17024827.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 094ZI81Y45 / Tamoxifen; 0F65R8P09N / Goserelin; PXW8U3YXDV / Buserelin
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10. Whittle P C, Sánchez R L, Albarracin G J, Hepp K J: [Retroperitoneal fibromatosis: report of a case]. Rev Med Chil; 2006 Jan;134(1):85-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Retroperitoneal fibromatosis: report of a case].
  • [Transliterated title] Fibromatosis mesentérica: caso clínico-imagenológico y revisión bibliográfica.
  • We report a 42 years old female that presented with abdominal pain and no palpable mass.
  • Imaging abdominal ultrasound, CAT scan and magnetic resonance showed a solid tumor located in the retroperitoneum.
  • The patient was operated on excising the tumor.
  • Pathological examination of the surgical piece disclosed a retroperitoneal fibromatosis or desmoid tumor.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Retroperitoneal Neoplasms / diagnosis

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  • (PMID = 16532167.001).
  • [ISSN] 0034-9887
  • [Journal-full-title] Revista médica de Chile
  • [ISO-abbreviation] Rev Med Chil
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Chile
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11. Sturt NJ, Clark SK: Current ideas in desmoid tumours. Fam Cancer; 2006;5(3):275-85; discussion 287-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Current ideas in desmoid tumours.
  • Desmoid tumours are rare neoplasms of fibroblastic origin which arise with disproportionate frequency in patients with familial adenomatous polyposis (FAP).
  • Such loss of wild-type APC seems to occur relatively late in tumour development.
  • FAP-associated desmoids tend to arise in the abdomen or abdominal wall.
  • CT scanning gives the best information on tumour anatomy whilst T2-weighted MRI indicates likely behaviour.
  • Surgery is a reasonable first-line treatment in abdominal wall tumours but is risky for intra-abdominal tumours and may necessitate massive small bowel resection.
  • Desmoids are the greatest remaining challenge in the management of FAP and further research into their aetiology needs to be combined with multicentre clinical trials of new treatments in order to improve management of the disease.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Fibromatosis, Abdominal / etiology. Fibromatosis, Aggressive / etiology

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  • (PMID = 16998673.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 68
  •  go-up   go-down


12. Singh N, Sharma R, Dorman SA, Dy VC: An unusual presentation of desmoid tumor in the ileum. Am Surg; 2006 Sep;72(9):821-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual presentation of desmoid tumor in the ileum.
  • Desmoid tumors are nonencapsulated, locally invasive tumors of fibrous origin.
  • Intra-abdominal desmoids are commonly found in the mesentery.
  • We present the report of a case in which a sporadic desmoid tumor originated from the wall of the ileum.
  • Of all the options described, surgery with tumor-free margins has been defined as the best treatment modality.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Ileal Neoplasms / diagnosis

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  • (PMID = 16986393.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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13. Polat C, Aktepe F, Turel S, Yazicioglu B, Ozkececi T, Arikan Y: A giant mesenteric fibromatosis case presenting with mechanical intestinal obstruction and successfully resected with partial duodeno-jejunectomy and right hemicolectomy. Clinics (Sao Paulo); 2010;65(1):110-3
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  • [Title] A giant mesenteric fibromatosis case presenting with mechanical intestinal obstruction and successfully resected with partial duodeno-jejunectomy and right hemicolectomy.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Intestinal Obstruction / etiology. Mesentery / pathology. Peritoneal Neoplasms / pathology
  • [MeSH-minor] Colectomy / methods. Diagnosis, Differential. Duodenum / surgery. Humans. Jejunum / surgery. Male. Middle Aged

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  • (PMID = 20126354.001).
  • [ISSN] 1980-5322
  • [Journal-full-title] Clinics (São Paulo, Brazil)
  • [ISO-abbreviation] Clinics (Sao Paulo)
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Brazil
  • [Other-IDs] NLM/ PMC2815273
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14. Suárez Artacho G, Jiménez Rodríguez R, Díaz Pavón JM, Sánchez Gil J, Vázquez Monchul J: [Desmoid tumor arising in a laparoscopic trocar site after cholectomy]. Rev Esp Enferm Dig; 2009 Nov;101(11):814-5
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  • [Title] [Desmoid tumor arising in a laparoscopic trocar site after cholectomy].
  • [Transliterated title] Tumor desmoide sobre cicatriz de trocar tras colectomía laparoscópica.
  • [MeSH-major] Abdominal Wall. Cicatrix / etiology. Colectomy / methods. Fibromatosis, Aggressive / etiology. Laparoscopy / adverse effects

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  • (PMID = 20001161.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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15. Sun L, Wu H, Zhuang YZ, Guan YS: A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us? World J Gastroenterol; 2007 Mar 14;13(10):1632-5
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  • [Title] A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us?
  • Mesenteric fibromatosis is a rare benign nonmetastatic neoplasm that appears as a sporadic lesion or occurs in patients with familial polyposis, while chylous ascites associated with aggressive mesenteric fibromatosis during pregnancy has never been reported thus far.
  • Here we present the case of a 28-year old pregnant woman, in whom an aggressive mesenteric fibromatosis with chylous ascites was detected, involving the jejunum, superior mesenteric artery (SMA) and superior mesenteric vein (SMV) and pancreas.
  • The authors report the case for its rarity and emphasize on combining clinicopathological, radiological and immunohistochemistry analysis for management of the disease.
  • [MeSH-major] Chylous Ascites / etiology. Fibromatosis, Abdominal / complications. Fibromatosis, Abdominal / diagnosis. Pregnancy Complications / diagnosis
  • [MeSH-minor] Adult. Female. Humans. Magnetic Resonance Imaging. Mesentery / pathology. Mesentery / radiography. Peritoneal Neoplasms / complications. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / pathology. Pregnancy. Tomography, Spiral Computed

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  • (PMID = 17461463.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC4146913
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16. Frade Mera MJ, Jacue Izquierdo S, Fontan Vinagre G, Montejo González JC: [Course and cares of intestinal transplant in immediate post-operative period]. Enferm Intensiva; 2007 Apr-Jun;18(2):61-9
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  • Reason for intestinal transplant: 75% familial adenomatous polyposis with desmoid tumor and 25% mesenteric artery obstruction.
  • All the patients were carrier of central and arterial venous catheters, and Jackson Pratt abdominal drains (50% two, 50% three).

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  • (PMID = 17570192.001).
  • [ISSN] 1130-2399
  • [Journal-full-title] Enfermeria intensiva
  • [ISO-abbreviation] Enferm Intensiva
  • [Language] SPA
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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17. Spree E, Niemann U, Wenisch H: [Sporadical extraperitoneal desmoid tumors--review and report on 4 cases]. Zentralbl Chir; 2005 Oct;130(5):449-53
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  • [Title] [Sporadical extraperitoneal desmoid tumors--review and report on 4 cases].
  • INTRODUCTION: Desmoid tumors are very rare mesenchymal tumors with a partially aggressive growth pattern and high relapse rates.
  • CASE REPORTS: We report the follow-up of 4 patients who were treated for desmoid tumours.
  • On account of the previous experiences, it can be concluded that therapy of primary non respectable or recurrent desmoid tumours is not only a domain of a surgical approach.
  • For generally accepted guidelines for this rare disease, general therapeutic options based on prospectively randomised studies have to be elaborated.
  • [MeSH-major] Abdominal Neoplasms / surgery. Fibromatosis, Aggressive / surgery. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Recurrence, Local / surgery. Thoracic Neoplasms / surgery
  • [MeSH-minor] Abdominal Wall / pathology. Abdominal Wall / surgery. Adult. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Radiotherapy, Adjuvant. Reoperation

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  • (PMID = 16220442.001).
  • [ISSN] 0044-409X
  • [Journal-full-title] Zentralblatt für Chirurgie
  • [ISO-abbreviation] Zentralbl Chir
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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18. Schlemmer M: Desmoid tumors and deep fibromatoses. Hematol Oncol Clin North Am; 2005 Jun;19(3):565-71, vii-viii
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  • [Title] Desmoid tumors and deep fibromatoses.
  • Desmoid tumors (also called deep fibromatoses) are rare benign tumors associated with pregnancy and Gardner syndrome.
  • They arise in the abdominal cavity, in the abdominal wall, or in the extremities/trunk, each with a slightly different biologic behavior.
  • This article highlights the biology and clinical features of desmoid tumors.
  • [MeSH-major] Fibromatosis, Aggressive. Gardner Syndrome

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  • (PMID = 15939197.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 44
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19. Soon JL, Lau WK, Seow-Choen F, Cheng CW: Unresectable desmoid tumours causing obstructive uropathy in familial adenomatous polyposis. Asian J Surg; 2005 Jul;28(3):233-7
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  • [Title] Unresectable desmoid tumours causing obstructive uropathy in familial adenomatous polyposis.
  • Desmoid tumour-related ureteral obstruction in familial adenomatous polyposis presents difficult management problems.
  • Both our patients developed intra-abdominal desmoid tumours following proctocolectomies with pouch reconstruction (performed 0.7 and 2.5 years earlier).

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  • (PMID = 16024324.001).
  • [ISSN] 1015-9584
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 12
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20. Shi B, Zhu Y, Xu Z, Liu Y, Zheng B, Qi T: Aggressive fibromatosis in the urological system. Report of two adult patients and review of the literature. Urol Int; 2007;78(1):93-6
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  • [Title] Aggressive fibromatosis in the urological system. Report of two adult patients and review of the literature.
  • Aggressive fibromatoses (AF) are locally aggressive neoplasms that do not metastasize but are frequently associated with one or more recurrences and subsequent associated morbidity.
  • AF in the urological system is quite rare and has mainly been described in single case reports or as isolated cases in a large series of extra-abdominal desmoid tumors.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Genital Neoplasms, Male / diagnosis. Scrotum. Urinary Bladder Neoplasms / diagnosis
  • [MeSH-minor] Adult. Cystoscopy. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Tomography, X-Ray Computed. Urography. Urologic Surgical Procedures, Male / methods


21. Dafford K, Kim D, Nelson A, Kline D: Extraabdominal desmoid tumors. Neurosurg Focus; 2007;22(6):E21
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  • [Title] Extraabdominal desmoid tumors.
  • OBJECT: Desmoid tumors are fibrous, slow-growing, nonmalignant tumors with a low potential for metastasis.
  • METHODS: The authors undertook a retrospective study of 15 desmoid tumors in 11 women and four men (ranging in age from 32 to 67 years; median 48 years) treated at their institution.
  • There was tumor recurrence in two patients (13%) leading to further surgical intervention.
  • CONCLUSIONS: This case series included many recurrent desmoid tumors of the brachial plexus.
  • Currently, function-sparing excision is considered the optimal treatment for desmoid tumors arising in extraabdominal sites.
  • Adjunctive radiation or brachytherapy is reserved for a patient with further recurrence in whom resection would be disfiguring or in whom the disease is more refractory.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Abdominal / surgery
  • [MeSH-minor] Adult. Aged. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Postoperative Complications / diagnosis. Postoperative Complications / pathology. Postoperative Complications / surgery. Retrospective Studies

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  • (PMID = 17613213.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Case Reports; Comparative Study; Journal Article
  • [Publication-country] United States
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22. Fakhar S, Qazi MP, Saeed G, Ashraf M, Tariq N: Successful surgical removal of a huge pelvic desmoid tumor. Taiwan J Obstet Gynecol; 2010 Sep;49(3):361-3
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  • [Title] Successful surgical removal of a huge pelvic desmoid tumor.
  • [MeSH-major] Fibromatosis, Abdominal / surgery. Fibromatosis, Aggressive / surgery. Radiography, Abdominal. Severity of Illness Index. Tomography, X-Ray Computed
  • [MeSH-minor] Abdomen. Adult. Female. Humans

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  • (PMID = 21056325.001).
  • [ISSN] 1875-6263
  • [Journal-full-title] Taiwanese journal of obstetrics & gynecology
  • [ISO-abbreviation] Taiwan J Obstet Gynecol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] China
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23. Amiot A, Dokmak S, Sauvanet A, Vilgrain V, Bringuier PP, Scoazec JY, Sastre X, Ruszniewski P, Bedossa P, Couvelard A: Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion. JOP; 2008;9(3):339-45
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  • [Title] Sporadic desmoid tumor. An exceptional cause of cystic pancreatic lesion.
  • CONTEXT: Desmoid tumors are rare, benign soft tissue tumors, characterized by the proliferation of fibroblasts in an abundant collagen extra-cellular matrix.
  • Intra-abdominal forms involve the mesentery and retroperitoneum and usually occur associated with familial adenomatous polyposis or Gardner's syndrome.
  • Although desmoid tumors do not metastasize, their evolution can be life-threatening due to aggressive local invasion, such as mesentery involvement.
  • CASE REPORT: We herein report a very rare location of sporadic desmoid tumors involving the pancreatic tail, presenting as a cystic lesion.
  • A 51-year-old woman presented with recurrent abdominal pain and weight loss.
  • The diagnosis of mucinous cystadenocarcinoma was suspected preoperatively and the patient underwent a splenopancreatectomy with en-bloc resection of the left colonic flexure, duodenojejunal junction and part of the posterior gastric wall.
  • Pathological analysis revealed fibroblastic proliferation arising in musculoaponeurotic structures consistent with a desmoid tumor.
  • The diagnosis was confirmed by immunocytochemical analysis and the assessment of the beta-catenin gene mutation.
  • No treatment was given postoperatively to prevent desmoid tumor recurrence.
  • CONCLUSION: Desmoid tumors are very rare in the pancreas and their diagnosis can be difficult, such as in our case where it presented as a cystic lesion.
  • In contrast to intra-abdominal forms, sporadic pancreatic desmoid tumors are more frequent than those associated with familial adenomatous polyposis.
  • [MeSH-major] Fibromatosis, Abdominal / etiology. Pancreatic Cyst / complications
  • [MeSH-minor] Abdominal Pain / diagnosis. Abdominal Pain / etiology. Female. Humans. Middle Aged

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  • (PMID = 18469451.001).
  • [ISSN] 1590-8577
  • [Journal-full-title] JOP : Journal of the pancreas
  • [ISO-abbreviation] JOP
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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24. de Bree E, Keus R, Melissas J, Tsiftsis D, van Coevorden F: Desmoid tumors: need for an individualized approach. Expert Rev Anticancer Ther; 2009 Apr;9(4):525-35
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  • [Title] Desmoid tumors: need for an individualized approach.
  • Desmoid tumor, also known as aggressive fibromatosis or desmoid-type fibromatosis, is a rare monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures.
  • Since it is a heterogeneous disease, in particular regarding clinical presentation, anatomic location and biological behavior, treatment should be individualized to reduce local tumor control failure with concurrently acceptable morbidity and preservation of quality of life.
  • Radiotherapy for gross disease is considerably effective, but is associated with a relatively high rate of complications, which are usually mild or moderate and radiation dose dependent.
  • Risk factors for local tumor control failure include young age, large size, presentation as recurrent disease, limb/girdle or intra-abdominal location, involved surgical margins, omission of radiotherapy, radiation dose less than 50 Gy and insufficient radiation field size.
  • Considering the significant morbidity of surgery and/or radiotherapy for certain locations, especially mutilation and loss of function, and the tumor's natural history, which is often characterized by prolonged periods of stability or even regression, a period of watchful waiting may compose the most appropriate management in selected asymptomatic patients.
  • Attempts to complete eradication of the disease may be worse than the disease itself.
  • [MeSH-major] Fibromatosis, Aggressive / therapy

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  • (PMID = 19374605.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cyclooxygenase 2 Inhibitors
  • [Number-of-references] 89
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25. Stengel G, Metze D, Dörflinger B, Luger TA, Böhm M: Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon. J Am Acad Dermatol; 2008 Aug;59(2 Suppl 1):S7-9
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  • [Title] Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon.
  • Aggressive fibromatosis (desmoid tumor) is a very rare neoplasm arising from the musculoaponeurotic structures.
  • We report on a young woman with a large desmoid tumor of the left foot.
  • Long-term immunointervention with pegylated interferon alfa-2b, however, led to marked clinical improvement of the patient's condition and a radiologically proven stabilization of the disease.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Fibromatosis, Aggressive / drug therapy. Foot. Interferon-alpha / administration & dosage. Soft Tissue Neoplasms / drug therapy

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  • (PMID = 18625396.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Interferon-alpha; 0 / Recombinant Proteins; 0 / peginterferon alfa-2b; 30IQX730WE / Polyethylene Glycols; 99210-65-8 / interferon alfa-2b
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26. Michopoulou A, Germanos S, Kanakopoulos D, Milonas A, Orfanos N, Spyratou C, Markidis P: Management of a large abdominal wall desmoid tumor during pregnancy. Case report. Ann Ital Chir; 2010 Mar-Apr;81(2):153-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of a large abdominal wall desmoid tumor during pregnancy. Case report.
  • Desmoid tumors, characterized by aggressive local infiltration of surrounding tissues, are uncommon benign neoplasms with no metastatic potential, that occasionally may attain large size.
  • We report a case of a 37-year-old woman with an abdominal wall desmoid tumor that appeared and grew rapidly during her pregnancy, diagnosed by trucut core biopsy.
  • Complete surgical excision of a 20 x 16 cm in size tumor and immediate reconstruction with mesh was performed in the postpartum period.
  • Optimal management of large abdominal wall desmoids during pregnancy has to be individualized, with wide surgical excision remaining the treatment of choice.
  • [MeSH-major] Abdominal Wall. Fibromatosis, Aggressive / surgery. Pregnancy Complications, Neoplastic / surgery


27. Huang PW, Tzen CY: Prognostic factors in desmoid-type fibromatosis: a clinicopathological and immunohistochemical analysis of 46 cases. Pathology; 2010 Feb;42(2):147-50
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  • [Title] Prognostic factors in desmoid-type fibromatosis: a clinicopathological and immunohistochemical analysis of 46 cases.
  • AIMS: To determine risk factors for recurrence of desmoid-type fibromatosis (aggressive fibromatosis).
  • METHODS: Forty-six cases of desmoid-type fibromatosis in Taiwanese patients were analysed for an association between tumour recurrence and clinical features, pathology, and the presence of p53 protein and beta-catenin on immunohistochemical staining.
  • The only factor significantly associated with tumour recurrence was positive surgical margin (p = 0.035).
  • CONCLUSIONS: A positive surgical margin is a risk factor for recurrence of desmoid-type fibromatosis.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Male. Neoplasm Recurrence, Local. Prognosis. Risk Factors. Tumor Suppressor Protein p53 / metabolism. beta Catenin / metabolism

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  • (PMID = 20085516.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CTNNB1 protein, human; 0 / Tumor Suppressor Protein p53; 0 / beta Catenin
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28. Moon JI, Selvaggi G, Nishida S, Levi DM, Kato T, Ruiz P, Bejarano P, Madariaga JR, Tzakis AG: Intestinal transplantation for the treatment of neoplastic disease. J Surg Oncol; 2005 Dec 15;92(4):284-91
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  • [Title] Intestinal transplantation for the treatment of neoplastic disease.
  • BACKGROUND: Authors reviewed single center experience of intestinal transplantation for treatment of intra-abdominal neoplastic disease.
  • METHODS: There were 25 auto- or allograft transplantations in 21 patients; desmoid tumor (14), neuroendocrine tumor (2), adenocarcinoma (2), hemangioma (1), lymphoma (1), and solid pseudopapillary tumor (1).
  • Six patients experienced recurrent disease; three desmoid tumor (3/14), two adenocarcinoma (2/2), and one neuroendocrine tumor (1/2).
  • Recurrent desmoid tumors were successfully treated with simple excision.
  • Patient and graft survival in the desmoid tumor are 69.2% and 50.0% at 5 years after transplant.
  • CONCLUSIONS: Intestinal transplantation is a reasonable life-saving treatment for catastrophic intra-abdominal neoplastic diseases.
  • [MeSH-major] Abdominal Neoplasms / surgery. Fibromatosis, Abdominal / surgery. Graft Survival. Intestines / transplantation
  • [MeSH-minor] Adolescent. Adult. Child, Preschool. Duodenum / transplantation. Female. Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / surgery. Graft Rejection. Humans. Liver Transplantation. Male. Middle Aged. Pancreas Transplantation. Quality of Life. Recurrence. Stomach / transplantation. Survival Analysis. Transplantation, Homologous

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  • [Copyright] 2005 Wiley-Liss, Inc.
  • [CommentIn] J Surg Oncol. 2005 Dec 15;92(4):272-3 [16299793.001]
  • (PMID = 16299803.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / 1 R03 DK061445-01 A2
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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29. Agrawal PS, Jagtap SM, Mitra SR: Extra-abdominal desmoid tumour of the leg. Singapore Med J; 2008 Jan;49(1):e6-7
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  • [Title] Extra-abdominal desmoid tumour of the leg.
  • Extra-abdominal desmoid tumour is a rare tumour and only a few cases occurring in the limbs have been reported.
  • She had a mild, dull, aching pain in the tumour.
  • Wide local excision was done and the tumour was found mainly in the subcutaneous tissue, which histopathologically proved to be an extra-abdominal desmoid tumour.
  • This case had an abnormal radiological appearance of peripheral calcification of tumour and saucer-shaped lesion in the underlying tibial cortex.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Leg / pathology. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy. Disease-Free Survival. Female. Humans. Treatment Outcome

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  • (PMID = 18204758.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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30. Nieuwenhuis MH, Hartgrink HH, Meijer S, Menko FH, Vasen HF: [Desmoid tumour as indication of familial adenomatous polyposis]. Ned Tijdschr Geneeskd; 2010;154:A2235
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  • [Title] [Desmoid tumour as indication of familial adenomatous polyposis].
  • In two patients, a man aged 43 and a woman aged 40 years, who presented with a desmoid tumour, familial adenomatous polyposis (FAP) was diagnosed three and six years later, respectively.
  • Desmoid-type fibromatoses usually develop sporadically, but may also be an extracolonic manifestation of FAP.
  • All patients with desmoids diagnosed who are under age 60, or with desmoids located intra-abdominally or in the abdominal wall, should be referred for colonic and genetic evaluation.
  • In all further patients with a desmoid tumour, the possibility of FAP should be considered and patient data and the family history should be evaluated thoroughly.
  • [MeSH-major] Adenomatous Polyposis Coli / diagnosis. Adenomatous Polyposis Coli / pathology. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / pathology
  • [MeSH-minor] Adult. Colonic Neoplasms / diagnosis. Colonic Neoplasms / secondary. Colonic Neoplasms / surgery. Female. Genes, APC. Genetic Predisposition to Disease. Humans. Male. Mutation. Neoplasm Metastasis. Rectal Neoplasms / diagnosis. Rectal Neoplasms / secondary. Rectal Neoplasms / surgery

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  • (PMID = 20977806.001).
  • [ISSN] 1876-8784
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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31. Al-Otaibi ML, Turcotte RE, Hings I, Beaudet J, Isler M, Nahal A, Wong C: Low-dose chemotherapy for extra-abdominal desmoid tumor. Saudi Med J; 2008 Dec;29(12):1730-4
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  • [Title] Low-dose chemotherapy for extra-abdominal desmoid tumor.
  • OBJECTIVE: To assess the outcome of patients with extra-abdominal desmoid tumor treated with low dose chemotherapy (methotrexate and vinblastine) both for tumor response and treatment related toxicity.
  • METHODS: We retrospectively reviewed the outcome of 12 patients who underwent low dose chemotherapy for extra abdominal desmoid of different locations.
  • We evaluated the patients for their compliance, tumor response, complications of treatment, and impact of treatment on symptoms.
  • RESULTS: Disease related morbidity included pain in 7 patients, functional limitation in 7 and cosmetic defects in 3.
  • The mean tumor size was 11 cm (3-20 cm).

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  • (PMID = 19082222.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Saudi Arabia
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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32. Spiridakis K, Panagiotakis G, Grigoraki M, Kokkinos I, Papadakis T, Kokkinakis T, Kandylakis S: Isolated giant mesenteric fibromatosis (intra-abdominal desmoid tumors). Case report. G Chir; 2008 Oct;29(10):413-6
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  • [Title] Isolated giant mesenteric fibromatosis (intra-abdominal desmoid tumors). Case report.
  • A rare case of isolated giant mesenteric fibromatosis is presented.
  • The tumor originated from the fibrous mesenteric tissue.
  • The patient underwent laparotomy because of abdominal discomfort and sub-occlusive symptoms due to the giant mass.
  • Differential diagnosis of mesenteric masses is discussed and the Authors also review the literature concerning this rare disease.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Abdominal / surgery. Peritoneal Neoplasms / diagnosis. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Diagnosis, Differential. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / surgery. Humans. Male. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18947463.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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33. Bölke E, Krasniqi H, Lammering G, Engers R, Matuschek C, Gripp S, Gerber PA, Fischer G, Peiper M, Shaikh S, Budach W, Orth K: Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature. Eur J Med Res; 2009 Jun 18;14(6):240-3
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  • [Title] Chest wall and intrathoracic desmoid tumors: surgical experience and review of the literature.
  • Desmoid tumors are fibroblastic/myofibroblastic neoplasms, which originate from musculo-aponeurotic structures and are classified as deep fibromatoses.
  • Despite their benign histologic appearance and lack of metastatic potential, desmoid tumors may cause aggres?sive local infiltrations and compression of surrounding structures.
  • Radical tumor resection with free margins remains the first therapy of choice.
  • [MeSH-major] Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Thoracic Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 19541583.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
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34. Picariello L, Carbonell Sala S, Martineti V, Gozzini A, Aragona P, Tognarini I, Paglierani M, Nesi G, Brandi ML, Tonelli F: A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells. Anal Biochem; 2006 Jul 15;354(2):205-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells.
  • These tumors may be sporadic or associated with a genetic disease such as familial adenomatous polyposis (FAP).
  • Although surgery is widely accepted as the first-line treatment for extra-abdominal and abdominal wall desmoids, a proportion of cases are successfully palliated with either estrogen antagonists (tamoxifen, toremifene, and raloxifene) or nonsteroidal anti-inflammatory drugs.
  • We describe and compare four methods for evaluating the expression of estrogen receptors alpha/beta and COX-1 and COX-2 in desmoid tumor-derived cells and tissues: immunocytochemistry, immunohistochemistry, RT-PCR, and two-color Western blot detection with the Odyssey infrared imaging system.
  • Through this comparative analysis, Western blot with Odyssey was recognized as the best method to analyze the expression particularly of low expressed proteins in desmoid-derived cells.
  • [MeSH-major] Fibromatosis, Aggressive / metabolism. Neoplasm Proteins / analysis. Neoplasm Proteins / metabolism
  • [MeSH-minor] Base Sequence. Blotting, Western. Cyclooxygenase 1 / analysis. Cyclooxygenase 1 / genetics. Cyclooxygenase 1 / metabolism. Cyclooxygenase 2 / analysis. Cyclooxygenase 2 / genetics. Cyclooxygenase 2 / metabolism. Estrogen Receptor alpha / analysis. Estrogen Receptor alpha / genetics. Estrogen Receptor alpha / metabolism. Estrogen Receptor beta / analysis. Estrogen Receptor beta / genetics. Estrogen Receptor beta / metabolism. Gene Expression. Humans. Immunohistochemistry. Membrane Proteins / analysis. Membrane Proteins / genetics. Membrane Proteins / metabolism. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tumor Cells, Cultured

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  • (PMID = 16729958.001).
  • [ISSN] 0003-2697
  • [Journal-full-title] Analytical biochemistry
  • [ISO-abbreviation] Anal. Biochem.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Estrogen Receptor alpha; 0 / Estrogen Receptor beta; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 1.14.99.1 / Cyclooxygenase 1; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS1 protein, human; EC 1.14.99.1 / PTGS2 protein, human
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35. Soravia C, DeLozier CD, Dobbie Z, Berthod CR, Arrigoni E, Bründler MA, Blouin JL, Foulkes WD, Hutter P: Double frameshift mutations in APC and MSH2 in the same individual. Int J Colorectal Dis; 2005 Sep;20(5):466-470
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  • The number of polyps (less than ten) was not typical of polyposis; therefore, the diagnosis of HNPCC was entertained.
  • The tumour tissue showed high-grade instability, and subsequently, immunohistochemistry showed that neither MSH2 nor MSH6 proteins were expressed in tumour cells.
  • The patient later developed an intra-abdominal desmoid tumour.
  • [MeSH-minor] Adult. Colectomy. Diagnosis, Differential. Genetic Predisposition to Disease. Germ-Line Mutation. Humans. Male. Pedigree

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  • (PMID = 15834612.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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36. Jain P, Shah P, Bhansali M: Unusual presentation of an uncommon abdominal pathology. Ann R Coll Surg Engl; 2010 Oct;92(7):W19-21
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  • [Title] Unusual presentation of an uncommon abdominal pathology.
  • Desmoid tumour is a non-encapsulated locally invasive tumour, originating from fibroblasts, which has ubiquitous distribution in the body.
  • A case of a 75-year-old man, presenting with high-grade fever, dull aching abdominal pain and weight loss, suspected to be due to malignancy, is reported.
  • Histological analysis revealed mesenteric fibromatosis (desmoid tumour).
  • To the best of our knowledge, this is the first case on colonic perforation secondary to desmoid tumour.
  • [MeSH-major] Colonic Neoplasms / diagnosis. Fibromatosis, Aggressive / diagnosis
  • [MeSH-minor] Abdomen, Acute / etiology. Aged. Humans. Intestinal Perforation / etiology. Intestinal Perforation / surgery. Male. Tomography, X-Ray Computed

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  • (PMID = 20825702.001).
  • [ISSN] 1478-7083
  • [Journal-full-title] Annals of the Royal College of Surgeons of England
  • [ISO-abbreviation] Ann R Coll Surg Engl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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37. Privette A, Fenton SJ, Mone MC, Kennedy AM, Nelson EW: Desmoid tumor: a case of mistaken identity. Breast J; 2005 Jan-Feb;11(1):60-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Desmoid tumor: a case of mistaken identity.
  • Desmoid tumors are rare tumors accounting for only 0.03% of all neoplasms.
  • Mainly occurring in the fourth and fifth decades of life, these tumors originate in musculoaponeurotic tissues of the limbs, neck, trunk, abdominal wall, and mesentery.
  • We present a rare case of a chest wall desmoid tumor that was mistaken for breast cancer on both physical examination and mammography, which highlights the unique risk these tumors present for confusion with other malignant processes.
  • Although past literature contains numerous reports of other misdiagnoses, this case is unique in reporting the potential for misdiagnosis between chest wall desmoid tumors and breast cancer.
  • In cases where suspicious breast findings do not correlate to usual diagnostic measures, such as fine-needle aspiration or core needle biopsy, the possibility of another pathology such as a chest wall desmoid tumor mimicking breast cancer should be considered in the differential diagnosis.
  • [MeSH-major] Fibromatosis, Aggressive / diagnosis. Thoracic Neoplasms / diagnosis. Thoracic Wall
  • [MeSH-minor] Aged. Biopsy, Needle. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Breast Neoplasms / radiography. Breast Neoplasms / surgery. Breast Neoplasms / ultrasonography. Diagnosis, Differential. Female. Humans. Mammography. Mastectomy. Tomography, X-Ray Computed

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  • (PMID = 15647081.001).
  • [ISSN] 1075-122X
  • [Journal-full-title] The breast journal
  • [ISO-abbreviation] Breast J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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38. Ferenc T, Stalińska L, Turant M, Sygut J, Tosik D, Dziki A, Kulig A: Analysis of TGF-beta protein expression in aggressive fibromatosis (desmoid tumor). Pol J Pathol; 2006;57(2):77-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of TGF-beta protein expression in aggressive fibromatosis (desmoid tumor).
  • Aggressive fibromatosis, usually termed desmoid tumor, develops from muscle connective tissue, fasciae and aponeuroses.
  • Aggressive fibromatosis located in various parts of the body demonstrates differentiated biological behavior.
  • Abnormalities in TGF-beta expression are very common in many disease processes, including neoplasms.
  • Immunohistochemical analysis employing a monoclonal antibody against TGF-beta was performed on archival material, consisting of 38 cases of aggressive fibromatosis, among which 23 represented abdominal, 11 extra-abdominal and 4 intra-abdominal localizations.
  • The average percentage of cells positively stained for TGF-beta protein was 40.2% in the group of extra-abdominal, 58.5% in the group of abdominal and 72.8% in the group of intra-abdominal localizations.
  • There were significant differences observed between the analyzed groups of desmoid tumor (p<0.05).
  • A positive cytoplasmic reaction for TGF-beta was noted in 65.8% (25/38) of the aggressive fibromatoses.
  • Overexpression of TGF-beta protein was noted in 39.5% (15/38) of the aggressive fibromatoses.
  • High expression noticed in desmoid fibroblasts might indicate that this protein plays a crucial role in the development of aggressive fibromatosis.
  • [MeSH-major] Abdominal Neoplasms / metabolism. Fibromatosis, Aggressive / metabolism. Transforming Growth Factor beta / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Cell Count. Cytoplasm / metabolism. Cytoplasm / pathology. Fibroblasts / metabolism. Fibroblasts / pathology. Humans. Image Processing, Computer-Assisted. Immunoenzyme Techniques

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  • (PMID = 17019969.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Transforming Growth Factor beta
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39. Stoidis CN, Spyropoulos BG, Misiakos EP, Fountzilas CK, Paraskeva PP, Fotiadis CI: Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report. J Med Case Rep; 2010;4:314
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  • [Title] Surgical treatment of giant mesenteric fibromatosis presenting as a gastrointestinal stromal tumor: a case report.
  • INTRODUCTION: Intra-abdominal fibromatosis, usually located at the mesenteric level, is a locally invasive tumor of fibrous origin, with no ability to metastasize, but a tendency to recur.
  • Certain non-typical cases of intra-abdominal fibromatosis with involvement of the bowel wall can be misdiagnosed because of their different biological behavior.
  • CASE PRESENTATION: We describe the case of a 64-year-old Caucasian man presenting with mesenteric fibromatosis and involvement of the bowel wall, who was treated surgically.
  • The macroscopic and microscopic appearance of the lesion mimicked a gastrointestinal stromal tumor, a tumor with potential malignant behavior.
  • CONCLUSION: It is essential to make an early and correct diagnosis in such equivocal cases, so that the appropriate treatment can be chosen and suitable patients admitted to clinical trials if appropriate.
  • New and reliable criteria for discriminating between intra-abdominal fibromatosis and gastrointestinal stromal tumor should be proposed and established because novel sophisticated therapeutic strategies have been introduced in the international literature.

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  • (PMID = 20863383.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2955058
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40. Shatnawei A, Hamilton C, Quintini C, Steiger E, Kirby DF: Use of home parenteral nutrition in patients with intra-abdominal desmoid tumors. Nutr Clin Pract; 2010 Jun;25(3):290-5
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  • [Title] Use of home parenteral nutrition in patients with intra-abdominal desmoid tumors.
  • BACKGROUND: Fistulae, small bowel obstruction (SBO), and malabsorption are complications of intra-abdominal desmoid (IAD) tumors that require home parenteral nutrition (HPN).
  • [MeSH-major] Albumins / metabolism. Fibromatosis, Abdominal / complications. Parenteral Nutrition, Home / statistics & numerical data

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  • (PMID = 20581324.001).
  • [ISSN] 1941-2452
  • [Journal-full-title] Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • [ISO-abbreviation] Nutr Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Albumins; 0 / Dietary Proteins
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41. Doi J, Morita S: A case of mesenteric desmoid tumor of the jejunum. Jpn J Clin Oncol; 2009 Dec;39(12):859
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  • [Title] A case of mesenteric desmoid tumor of the jejunum.
  • [MeSH-major] Fibromatosis, Abdominal / epidemiology. Peritoneal Neoplasms / epidemiology

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  • (PMID = 19942588.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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42. Kadoch V, Bodin F, Himy S, Bollecker V, Wilk A, Bruant-Rodier C: Latissimus dorsi free flap for reconstruction of extensive full-thickness abdominal wall defect. A case of desmoid tumor. J Visc Surg; 2010 Apr;147(2):e45-8
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  • [Title] Latissimus dorsi free flap for reconstruction of extensive full-thickness abdominal wall defect. A case of desmoid tumor.
  • Desmoid tumor is a rare, benign fibroblastic tumor that is characterized by highly aggressive local invasiveness.
  • The authors report the case of a 35-year-old male who presented with a 20 cm para-umbilical tumor invading the right rectus abdominis muscle.
  • This required a wide excision of the abdominal wall.

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • [Cites] Ann Chir Plast Esthet. 1999 Aug;44(4):373-83 [10550916.001]
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  • (PMID = 20692637.001).
  • [ISSN] 1878-7886
  • [Journal-full-title] Journal of visceral surgery
  • [ISO-abbreviation] J Visc Surg
  • [Language] ENG
  • [Grant] United States / NEI NIH HHS / EY / EY015928-01; United States / NCRR NIH HHS / RR / RR001315-255511; United States / NEI NIH HHS / EY / F31 EY015928-01; United States / NCRR NIH HHS / RR / P41 RR001315-255511
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Other-IDs] NLM/ NIHMS218152; NLM/ PMC2924994
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43. Perenze B, Potì O, Margiotta A, Rega D, Marrano N, Minni F: [Mesenteric fibromatosis]. Chir Ital; 2005 Nov-Dec;57(6):717-22
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  • [Title] [Mesenteric fibromatosis].
  • [Transliterated title] La fibromatosi mesenterica.
  • Mesenteric fibromatosis is a rare benign mesenteric tumour, characterised by infiltrative growth and high rates of recurrence.
  • Histological examination is the only diagnostic procedure capable of ruling out a malignant mesenteric neoplasm.
  • It is not always possible to perform a radical removal of the tumour mass because it may have infiltrated important anatomical structures.
  • In the present study the Authors report two cases of mesenteric fibromatosis and analyse the main clinical-diagnostic, therapeutic and prognostic problems posed by these tumours.

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  • (PMID = 16400766.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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44. Rosoff PM, Larrier N, Rice HE: Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease. Pediatr Blood Cancer; 2005 Oct 15;45(5):728-31
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  • [Title] Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease.
  • The risk of second malignancies after successful treatment for Hodgkin disease can be considerable.
  • We describe a young woman who developed an intra-abdominal desmoid tumor more than 4 years after completing therapy for Stage IIB Hodgkin disease, treated with combination chemotherapy (ABVD) and mantle irradiation.
  • The tumor did not occur at either a surgical site or within a radiation field.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibromatosis, Aggressive / diagnosis. Hodgkin Disease / therapy. Neoplasms, Second Primary / diagnosis

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  • (PMID = 16035093.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Pho LN, Coffin CM, Burt RW: Abdominal desmoid in familial adenomatous polyposis presenting as a pancreatic cystic lesion. Fam Cancer; 2005;4(2):135-8
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  • [Title] Abdominal desmoid in familial adenomatous polyposis presenting as a pancreatic cystic lesion.
  • An abdominal CT scan detected a cystic pancreatic lesion of unknown etiology.
  • Histopathological examination of the resected specimen showed a benign pancreatic cyst and fibrous plaque with desmoid fibromatosis adherent to the surface of the pancreas, serosa of the stomach, and colon.
  • The fibrous plaque was histologically identical to the fibrous mesenteric plaque known to occur in FAP and associated mesenteric fibromatosis.
  • We present pathologic evidence that the pancreatic cyst formation was induced by FAP-associated desmoid invasion.
  • Desmoid growth should be considered in the differential diagnosis of a pancreatic cystic mass lesion in patients with FAP or its Gardner syndrome variant.
  • This case report provides the first pathologic evidence for benign epithelial cyst formation in the pancreas caused by fibromatosis invasion of that organ as a part of FAP.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Adenomatous Polyposis Coli / pathology. Fibromatosis, Aggressive / complications. Fibromatosis, Aggressive / diagnosis. Pancreatic Cyst / diagnosis. Pancreatic Cyst / etiology
  • [MeSH-minor] Adolescent. Chest Pain. Diagnosis, Differential. Humans. Male. Weight Loss

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  • (PMID = 15951964.001).
  • [ISSN] 1389-9600
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P01 CA 73992; United States / NCI NIH HHS / CA / P30 CA 42014; United States / NCI NIH HHS / CA / R01 CA 40641
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Netherlands
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46. Burnside KL, Ryan JT, Bielefeldt-Ohmann H, Gregory Bruce A, Thouless ME, Tsai CC, Rose TM: RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells. Virology; 2006 Oct 10;354(1):103-15
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  • [Title] RFHVMn ORF73 is structurally related to the KSHV ORF73 latency-associated nuclear antigen (LANA) and is expressed in retroperitoneal fibromatosis (RF) tumor cells.
  • Retroperitoneal fibromatosis herpesvirus (RFHV), the macaque homolog of the human rhadinovirus, Kaposi's sarcoma-associated herpesvirus (KSHV), was first identified in retroperitoneal fibromatosis (RF) tumor lesions of macaques with simian AIDS.
  • Immunohistochemical and immunofluorescence analysis revealed that RFHVMn LANA is a nuclear antigen which is highly expressed in RF spindloid tumor cells.
  • [MeSH-major] Antigens, Viral / genetics. Fibroma / virology. Nuclear Proteins / genetics. Open Reading Frames. Retroperitoneal Neoplasms / virology. Rhadinovirus / genetics
  • [MeSH-minor] Amino Acid Sequence. Animals. Antibodies, Monoclonal. Cell Nucleus / chemistry. Cloning, Molecular. DNA, Viral / chemistry. DNA, Viral / genetics. Immunohistochemistry. Macaca nemestrina. Microscopy, Fluorescence. Molecular Sequence Data. Protein Structure, Secondary. Protein Structure, Tertiary. Sequence Analysis, DNA. Sequence Homology, Amino Acid. Tumor Cells, Cultured

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  • (PMID = 16879850.001).
  • [ISSN] 0042-6822
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] eng
  • [Grant] United States / NIDCR NIH HHS / DE / DE07023; United States / NIAID NIH HHS / AI / K02 AI49275; United States / NCRR NIH HHS / RR / RR13154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antigens, Viral; 0 / DNA, Viral; 0 / Nuclear Proteins; 0 / latency-associated nuclear antigen
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47. Ezumi K, Yamamoto H, Takemasa I, Nomura M, Ikeda M, Sekimoto M, Monden M: Dacarbazine-Doxorubicin therapy ameliorated an extremely aggressive mesenteric desmoid tumor associated with familial adenomatous polyposis: report of a case. Jpn J Clin Oncol; 2008 Mar;38(3):222-6
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  • [Title] Dacarbazine-Doxorubicin therapy ameliorated an extremely aggressive mesenteric desmoid tumor associated with familial adenomatous polyposis: report of a case.
  • After 10 months, we found an intra-abdominal tumor, which grew rapidly to 25 cm in diameter.
  • We performed an emergency operation, which revealed that it was a desmoid tumor derived mainly from colorectal mesenterium.
  • The tumor was removed with three short segments of intestine and the left ureter.
  • A computed tomography (CT) scan done 3 months later showed a 10 cm mesenteric desmoid tumor at the beginning of jejunum, approaching the root of the superior mesenteric artery (SMA).
  • Fortunately, we were able to remove the tumor without injuring the SMA.
  • To our distress, however, another recurrent mesenteric desmoid tumor was discovered in the pelvis one month later, which grew rapidly from 5 cm to 16 cm within 4 months.
  • Finally, when the desmoid occupied the pelvic space, we gave the patient dacarbazine (DTIC) and doxorubicin (DOX).
  • After seven courses, the mesenteric tumor showed an almost complete response (CR).
  • No evidence of further recurrence of mesenteric desmoid has been seen for 4 years.
  • This combination chemotherapy is a promising strategy, even against an extremely aggressive, life-threatening mesenteric desmoid associated with FAP.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Dacarbazine / administration & dosage. Doxorubicin / administration & dosage. Fibromatosis, Aggressive / drug therapy. Mesentery. Peritoneal Neoplasms / drug therapy

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  • (PMID = 18304951.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 094ZI81Y45 / Tamoxifen; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; 8A1O1M485B / Imatinib Mesylate
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48. Kreuzberg B, Koudelova J, Ferda J, Treska V, Spidlen V, Mukensnabl P: Diagnostic problems of abdominal desmoid tumors in various locations. Eur J Radiol; 2007 May;62(2):180-5
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  • [Title] Diagnostic problems of abdominal desmoid tumors in various locations.
  • BACKGROUND: Abdominal desmoid tumor is one of the forms of deep (musculoaponeurotic) fibromatosis.
  • It occurs more often as a desmoid tumor in the abdominal wall, less often in various intra-abdominal locations.
  • In this work, we performed retrospective study concerning diagnostic problems of this disease with the use of imaging techniques.
  • RESULTS: The findings were typical only in the case with the lesion located in the abdominal wall, three described cases of the intra-abdominal desmoid provided a broad range of differentially diagnostic possibilities (metastases, GIT tumors, lymphomas, etc.).
  • In particular, the findings in infiltrative processes in intra-abdominal location and retroperitoneal involvement were less typical.
  • CONCLUSION: The possibility of the occurrence of intra-abdominal desmoid tumor must be considered particularly in younger individuals with rapidly growing tumorous process, which does not immediately arise from the surrounding organs (digestive tract, internal genitalia, etc.
  • ), and is located in the abdominal wall or in the abdominal cavity.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Aggressive / diagnosis
  • [MeSH-minor] Abdominal Cavity / pathology. Abdominal Wall / pathology. Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 17321093.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
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49. Toiyama Y, Konishi N, Inoue Y, Yoshiyama S, Araki T, Miki C, Kusunoki M: Successful treatment of ileal pouch desmoids using multimodal chemotherapy with low-dose vinblastine and methotrexate in a patient with familial adenomatous polyposis. Clin J Gastroenterol; 2009 Jun;2(3):170-174
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We describe a case of multiple desmoid tumors (DT) that developed in an ileal J pouch, which were successfully treated by low-dose combination chemotherapy using vinblastine (VBL) and methotrexate (MTX).
  • DT involving both the abdominal wall and the ileal pouch developed after total proctocolectomy with ileoanal anastomosis for familial adenomatous polyposis in a 26-year-old female who was treated in an outpatient unit with low-dose VBL and MTX biweekly for 12 months.
  • The treatment response was assessed at routine intervals by physical examination and abdominal computer tomography (CT) imaging.
  • Abdominal CT imaging revealed a decrease in tumor size, and the plasma D-dimer levels decreased in association with tumor regression.
  • This case report shows the efficacy of a low-dose combination chemotherapeutic regimen of VBL and MTX for the treatment of ileoanal pouch mesenteric DT in an outpatient setting.
  • In addition, plasma D-dimers may be a marker for desmoid tumor treatment efficacy.

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  • (PMID = 26192289.001).
  • [ISSN] 1865-7257
  • [Journal-full-title] Clinical journal of gastroenterology
  • [ISO-abbreviation] Clin J Gastroenterol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Keywords] NOTNLM ; Chemotherapy / D-dimer / Desmoid / FAP / Ileal pouch
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50. Ferenc T, Sygut J, Tosik D, Kopczyński J, Sidor M, Góźdź S, Kulig A, Dziki A, Turant M, Stalińska L: Analysis of p27KIP1 protein and Ki-67 expression in aggressive fibromatosis (desmoid tumor). Pol J Pathol; 2006;57(4):187-91
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  • [Title] Analysis of p27KIP1 protein and Ki-67 expression in aggressive fibromatosis (desmoid tumor).
  • Aggressive fibromatosis (desmoid tumor) is an uncommon locally invasive non-metastasizing neoplasm lesion.
  • Desmoid tumor consists of fibroblasts, miofibroblasts and a significant amount of extracellular matrix. p27KIP1 (p27) protein is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family that regulates progression through the cell cycle.
  • There were analysed 42 specimens of aggressive fibromatosis, in which there were 24 abdominal and 18 extra-abdominal cases.
  • There was no statistically significant difference between Ki-67 or p27 expression in abdominal and extra-abdominal location.
  • Analysis of p27 and Ki-67 expression levels might indicate that low proliferating activity of desmoid fibroblasts is connected with another mechanism than the one, in which p27 takes part.
  • [MeSH-major] Cyclin-Dependent Kinase Inhibitor p27 / metabolism. Fibromatosis, Abdominal / metabolism. Ki-67 Antigen / metabolism

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  • (PMID = 17285761.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27
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51. Umbach JL, Strelow LI, Wong SW, Cullen BR: Analysis of rhesus rhadinovirus microRNAs expressed in virus-induced tumors from infected rhesus macaques. Virology; 2010 Sep 30;405(2):592-9
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  • Using deep sequencing, we analyzed the pattern of small RNA expression in vivo using latently RRV-infected B-cell lymphoma and retroperitoneal fibromatosis tissues.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
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  • (PMID = 20655562.001).
  • [ISSN] 1096-0341
  • [Journal-full-title] Virology
  • [ISO-abbreviation] Virology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA132638; United States / NIAID NIH HHS / AI / R01-AI067968; United States / NIAID NIH HHS / AI / R01 AI067968; United States / NCI NIH HHS / CA / CA075922-14; United States / NCRR NIH HHS / RR / P51 RR000163; United States / NCI NIH HHS / CA / R01 CA132638-03; United States / NCI NIH HHS / CA / R01-CA075922; United States / NCI NIH HHS / CA / R01 CA075922-14; United States / NCI NIH HHS / CA / T32 CA009111; United States / NCRR NIH HHS / RR / K01 RR000163; United States / NCI NIH HHS / CA / T32-CA009111; United States / NCRR NIH HHS / RR / RR000163; United States / NCI NIH HHS / CA / R01 CA075922; United States / NCI NIH HHS / CA / CA132638-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Viral
  • [Other-IDs] NLM/ NIHMS219827; NLM/ PMC2923253
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52. Orzechowska BU, Manoharan M, Sprague J, Estep RD, Axthelm MK, Wong SW: Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD). J Med Primatol; 2009 Oct;38 Suppl 1:2-7
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  • [Title] Viral interleukin-6 encoded by rhesus macaque rhadinovirus is associated with lymphoproliferative disorder (LPD).
  • BACKGROUND: Rhesus macaques (RM) co-infected with simian immunodeficiency virus (SIV) and rhesus macaque rhadinovirus (RRV) develop abnormal cellular proliferations characterized as extra-nodal lymphoma and retroperitoneal fibromatosis (RF).
  • CONCLUSIONS: Our data support the idea that vIL-6 may be critical to the development and progression of lymphoproliferative disorder in RRV/SIV-infected RM.

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  • (PMID = 19863672.001).
  • [ISSN] 1600-0684
  • [Journal-full-title] Journal of medical primatology
  • [ISO-abbreviation] J. Med. Primatol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA132638; United States / NCI NIH HHS / CA / R01 CA075922-13; United States / NCRR NIH HHS / RR / P51 RR000163; United States / NCI NIH HHS / CA / CA075922-13; United States / NCI NIH HHS / CA / R01 CA132638-03; United States / NCRR NIH HHS / RR / RR00163; United States / NCI NIH HHS / CA / CA 75922; United States / NCRR NIH HHS / RR / K01 RR000163; United States / NCI NIH HHS / CA / R01 CA075922; United States / NCI NIH HHS / CA / CA132638-03
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Interleukin-6
  • [Other-IDs] NLM/ NIHMS262273; NLM/ PMC3022225
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53. Basdanis G, Papadopoulos VN, Panidis S, Tzeveleki I, Karamanlis E, Mekras A, Apostolidis S, Michalopoulos A: Desmoid tumor of mesentery in familial adenomatous polyposis: a case report. Tech Coloproctol; 2010 Nov;14 Suppl 1:S61-2
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  • [Title] Desmoid tumor of mesentery in familial adenomatous polyposis: a case report.
  • While a mass in the left lateral abdominal region was palpated.
  • Pathological examination revealed a desmoid tumor of the mesentery.
  • [MeSH-major] Adenomatous Polyposis Coli / surgery. Fibromatosis, Aggressive / surgery. Neoplasms, Second Primary / surgery. Peritoneal Neoplasms / surgery


54. Rosato L, Mondini G, Serbelloni M, Bertone P, Orlassino R, Cossavella D: [Intra-abdominal desmoid tumors: rare but important disease]. G Chir; 2007 Jan-Feb;28(1-2):20-4
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  • [Title] [Intra-abdominal desmoid tumors: rare but important disease].
  • Desmoid tumors are rare benign neoplasms with high tendency to local recurrence, and they can be divided into extra- and intra-abdominal types (mesenteric fibromatosis).
  • Six patients (3 men and 3 women) affected by extra-abdominal desmoid tumors have been treated with radical excision.
  • In two patients desmoid was intra-abdominal:.
  • 1) a 55 years old man admitted for acute abdomen and submitted, in emergency, to a laparotomy with excision of a mesenteric abscess including a jejunal loop at about one meter from Treitz;.
  • 2) 52 years old man, submitted to an elective excision of a capsulated neoplasm of the little omentum, which had caused an oppressive abdominal pain.
  • In both cases the hystological diagnosis has been desmoid tumor.
  • Surgical treatment of desmoid tumors must aim at radical excision to avoid frequent recurrences (25-65%); these have stimulated the research of other kinds of treatments, since a new surgical operation itself can lead to a further recurrence.
  • Radiotherapy has been investigated with results in 79-96% of cases, antiestrogenic therapy has been used with success in 51% of patients, and high dose tamoxifen seemed to obtain a stable disease in non operable cases.
  • Conclusive results on the efficacy of these treatments have not been obtained yet, because of the rarity of the desmoid tumors even in greater Centres.
  • [MeSH-major] Fibromatosis, Abdominal / surgery. Mesentery. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Abdominal Neoplasms / pathology. Abdominal Neoplasms / surgery. Aged. Female. Fibromatosis, Aggressive / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17313728.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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55. Tkachev SI, Aliev MD, Glebovskaia VV, Ivanov SM, Trofimova OP, Karapetian RM, Gutnik RA, Bokhian AIu: [Thermoradiotherapy as a component of desmoid tumor management: 10-year experience]. Vopr Onkol; 2005;51(3):347-9
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  • [Title] [Thermoradiotherapy as a component of desmoid tumor management: 10-year experience].
  • Data on radio- and thermoradiotherapy of 83 patients with extra-abdominal desmoid tumors are discussed.
  • Monitoring tumor temperature during local hyperthermia is a factor of relapse-free survival of vital importance.
  • [MeSH-major] Fibromatosis, Aggressive / radiotherapy. Hyperthermia, Induced
  • [MeSH-minor] Disease-Free Survival. Follow-Up Studies. Humans. Radiotherapy / methods. Treatment Outcome

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  • (PMID = 16279100.001).
  • [ISSN] 0507-3758
  • [Journal-full-title] Voprosy onkologii
  • [ISO-abbreviation] Vopr Onkol
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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56. Lee JC, Thomas JM, Phillips S, Fisher C, Moskovic E: Aggressive fibromatosis: MRI features with pathologic correlation. AJR Am J Roentgenol; 2006 Jan;186(1):247-54
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  • [Title] Aggressive fibromatosis: MRI features with pathologic correlation.
  • OBJECTIVE: We present the MRI features with pathologic correlation of aggressive fibromatosis, incorporating 203 cases over a 5-year period from the Royal Marsden Hospital Sarcoma Unit database.
  • MATERIALS AND METHODS: Sixty patients had imaging available for retrospective review of which 29 had preoperative MRI and final histopathologic diagnosis of aggressive fibromatosis.
  • RESULTS: The average age at diagnosis was 41.3 years with a female-to-male sex ratio of 1.2:1.
  • Twenty lesions were extraabdominal; six, intraabdominal; and three, in the abdominal wall (classic desmoid).
  • The average tumor size was 6.4 cm (range, 2.2-13.7 cm).
  • Intraabdominal aggressive fibromatosis produced the largest tumors, averaging 9.5 cm.
  • The lesions crossed major fascial boundaries in 31% of cases overall and in 66% of patients referred for recurrent disease.
  • Patients referred for recurrent disease were most likely to have a recurrence after surgery.
  • CONCLUSION: Accurate diagnosis and staging of aggressive fibromatosis by MRI have important treatment and prognostic implications.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Magnetic Resonance Imaging / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Fibromatosis, Abdominal / pathology. Humans. Male. Middle Aged. Prognosis. Recurrence


57. Joyce M, Mignanelli E, Church J: Ureteric obstruction in familial adenomatous polyposis-associated desmoid disease. Dis Colon Rectum; 2010 Mar;53(3):327-32
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  • [Title] Ureteric obstruction in familial adenomatous polyposis-associated desmoid disease.
  • PURPOSE: Intra-abdominal desmoid disease is the second leading cause of death in familial adenomatous polyposis patients.
  • The aim of this study was to identify the incidence, management, and outcomes for familial adenomatous polyposis associated intra-abdominal desmoids causing ureteric obstruction.
  • RESULTS: Of 107 patients identified with familial adenomatous polyposis related desmoid disease, 30 (28%) had documented CT scan evidence of ureteric obstruction.
  • Preceding surgery was the most prominent risk factor for development of desmoid disease (28 of 30 patients); 2 patients were diagnosed with desmoids before abdominal surgery.
  • Overall, 11 patients had ureteric obstruction at the time of diagnosis.
  • In the other 19 patients, median time from desmoid diagnosis to ureteric obstruction was 2 years.
  • One-third of patients required more than one urologic procedure, and 63% had extensive small-bowel involvement with desmoid.
  • CONCLUSIONS: The majority of patients with familial adenomatous polyposis associated desmoid disease who develop hydronephrosis require stenting.
  • Physicians treating patients with familial adenomatous polyposis and desmoid disease must be aware of the potential for development of ureteric obstruction and available treatment options.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Fibromatosis, Aggressive / complications. Ureteral Obstruction / etiology


58. Nishida Y, Tsukushi S, Shido Y, Wasa J, Ishiguro N, Yamada Y: Successful treatment with meloxicam, a cyclooxygenase-2 inhibitor, of patients with extra-abdominal desmoid tumors: a pilot study. J Clin Oncol; 2010 Feb 20;28(6):e107-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment with meloxicam, a cyclooxygenase-2 inhibitor, of patients with extra-abdominal desmoid tumors: a pilot study.
  • [MeSH-major] Cyclooxygenase 2 / chemistry. Cyclooxygenase Inhibitors / therapeutic use. Fibromatosis, Aggressive / drug therapy. Thiazines / therapeutic use. Thiazoles / therapeutic use

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  • (PMID = 20026797.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclooxygenase Inhibitors; 0 / Thiazines; 0 / Thiazoles; 71125-38-7 / meloxicam; EC 1.14.99.1 / Cyclooxygenase 2
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59. Bhosale PR, Patnana M, Viswanathan C, Szklaruk J: The inguinal canal: anatomy and imaging features of common and uncommon masses. Radiographics; 2008 May-Jun;28(3):819-35; quiz 913
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  • Benign causes of masses in the IC include spermatic cord lipoma, hematoma, abscess, neurofibroma, varicocele, desmoid tumor, air, bowel contrast material, hydrocele, and prostheses.
  • Metastases to the IC can occur from alveolar rhabdomyosarcoma, monophasic sarcoma, prostate cancer, Wilms tumor, carcinoid tumor, melanoma, or pancreatic cancer.
  • In patients with a known malignancy and peritoneal carcinomatosis, the diagnosis of metastases can be suggested when a mass is detected in the IC.
  • When peritoneal disease is not evident, a mass in the IC is indicative of stage IV disease and may significantly alter clinical and surgical treatment of the patient.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Inguinal Canal / pathology. Inguinal Canal / radiography. Peritoneal Diseases / diagnosis
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Middle Aged. Rare Diseases / diagnosis

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  • [Copyright] Copyright RSNA, 2008.
  • (PMID = 18480486.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 88
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60. Batori M, Chatelou E, Mariotta G, Sportelli G, Straniero A, Casella G, Casella MC: Giant mesenteric fibromatosis. Eur Rev Med Pharmacol Sci; 2005 Jul-Aug;9(4):223-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant mesenteric fibromatosis.
  • Mesenteric fibromatosis is a proliferative fibroblastic neoplasia of the small intestine mesentery which may occur as a unique or multiple formation.
  • Mesenteric fibromatosis represents the 8% of all desmoid neoplasm.
  • Giant mesenteric fibromatosis is uncommon by itself (2-4 case/milion/year).
  • Since the rarity of this tumor and the difficulties in diagnostic and therapeutic ambit, we believe it justified to describe a case of giant mesenteric fibromatosis which came to our observation.

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  • (PMID = 16128042.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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61. Rix TE: A 10-year review of surgery for desmoid disease associated with familial adenomatous polyposis (Br J Surg 2006; 93; 1258-1264). Br J Surg; 2007 Feb;94(2):250-1
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  • [Title] A 10-year review of surgery for desmoid disease associated with familial adenomatous polyposis (Br J Surg 2006; 93; 1258-1264).
  • [MeSH-major] Abdominal Neoplasms / therapy. Adenomatous Polyposis Coli / complications. Antineoplastic Agents / adverse effects. Fibromatosis, Aggressive / therapy. Sulindac / adverse effects. Tamoxifen / adverse effects

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  • [CommentIn] Br J Surg. 2007 Mar;94(3):385-6 [17315281.001]
  • [CommentOn] Br J Surg. 2006 Oct;93(10):1258-64 [16952208.001]
  • (PMID = 17256816.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 094ZI81Y45 / Tamoxifen; 184SNS8VUH / Sulindac
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62. Hatzimarkou A, Filippou D, Papadopoulos V, Filippou G, Rizos S, Skandalakis P: Desmoid tumor in Gardner's Syndrome presented as acute abdomen. World J Surg Oncol; 2006;4:18
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  • [Title] Desmoid tumor in Gardner's Syndrome presented as acute abdomen.
  • BACKGROUND: Gardner's syndrome can occasionally be complicated with intra-abdominal desmoid tumor.
  • CASE PRESENTATION: A rare case of a 41-year-old male patient with Gardner's syndrome complicated with intra-abdominal desmoid tumor, which first presented as acute abdomen, is presented.
  • CONCLUSION: Extra-abdominal manifestations of Gardner's syndrome along with a palpable abdominal mass would raise suspicion for the presence of a desmoid tumor in the majority of cases.

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  • (PMID = 16569244.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1479346
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63. Bielefeldt-Ohmann H, Barouch DH, Bakke AM, Bruce AG, Durning M, Grant R, Letvin NL, Ryan JT, Schmidt A, Thouless ME, Rose TM: Intestinal stromal tumors in a simian immunodeficiency virus-infected, simian retrovirus-2 negative rhesus macaque (Macaca mulatta). Vet Pathol; 2005 May;42(3):391-6
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  • Polymerase chain reaction analysis of DNA from tumor and spleen tissue revealed abundant, preferential presence of retroperitoneal fibromatosis herpesvirus, the macaque homologue of the Kaposi sarcoma-associated herpesvirus (human herpesvirus-8), in the tumors.
  • This was corroborated by demonstration of viral latent nuclear antigen-1 in the nuclei of a majority of the spindeloid tumor cells.
  • Low levels of an additional macaque herpesvirus, rhesus rhadinovirus, were also detected in the spleen and tumor tissues.

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  • (PMID = 15872392.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / K02-AI49275; United States / NIAID NIH HHS / AI / N01-AI-15431; United States / NCRR NIH HHS / RR / P51RR00166; United States / NCRR NIH HHS / RR / R01-RR13154
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Nuclear; 0 / DNA Primers; 0 / Vimentin
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64. Papagelopoulos PJ, Mavrogenis AF, Mitsiokapa EA, Papaparaskeva KT, Galanis EC, Soucacos PN: Current trends in the management of extra-abdominal desmoid tumours. World J Surg Oncol; 2006;4:21
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  • [Title] Current trends in the management of extra-abdominal desmoid tumours.
  • Extra-abdominal desmoid tumours are slow-growing, histologically benign tumours of fibroblastic origin with variable biologic behaviour.
  • Magnetic resonance imaging is the modality of choice for the diagnosis and the evaluation of the tumours.
  • Wide margin surgical resection remains the main treatment modality for local control of the tumour.
  • Chemotherapy may be used for recurrent or unresectable disease.
  • Overall local recurrence rates vary and depend on patient's age, tumour location and margins at resection.

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  • (PMID = 16584569.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1456964
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65. Janitzky A, Porsch M, Daher M, Küster D, Liehr UB: [Aggressive fibromatosis (desmoid tumor) : A rare differential diagnosis of metastasis of renal cell carcinoma]. Urologe A; 2010 Jan;49(1):81-3
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  • [Title] [Aggressive fibromatosis (desmoid tumor) : A rare differential diagnosis of metastasis of renal cell carcinoma].
  • [Transliterated title] Aggressive Fibromatose (Desmoidfibromatose) : Seltene Differentialdiagnose einer Nierenzellkarzinommetastase.
  • We report the case of a 65-year-old woman with an aggressive fibromatosis of the rectus abdominis muscle suspicious for a metastasis of renal cell carcinoma after tumor nephrectomy 3 years previously.
  • Aggressive fibromatoses (desmoid tumors) are rare semimalignant tumors of the connective tissue with local infiltration and destruction of tissue.
  • Complete resection is essential to avoid tumor relapse.
  • Aggressive fibromatosis must be considered in the differential diagnosis of renal cell carcinoma metastasis.
  • [MeSH-major] Abdominal Muscles / pathology. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / secondary. Fibromatosis, Abdominal / diagnosis. Kidney Neoplasms / diagnosis. Muscle Neoplasms / pathology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans


66. Levy AD, Rimola J, Mehrotra AK, Sobin LH: From the archives of the AFIP: benign fibrous tumors and tumorlike lesions of the mesentery: radiologic-pathologic correlation. Radiographics; 2006 Jan-Feb;26(1):245-64
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  • Mesenteric fibromatosis, sclerosing mesenteritis, inflammatory pseudotumor, and extrapleural solitary fibrous tumor constitute a loosely associated group of benign fibrous tumors and tumorlike lesions of the mesentery.
  • Mesenteric fibromatosis is a locally aggressive, benign proliferative process that may occur sporadically or in association with familial adenomatous polyposis.
  • It most frequently manifests as a focal mesenteric mass and may simulate lymphoma, metastatic disease, or a soft-tissue sarcoma.
  • Sclerosing mesenteritis is a rare idiopathic disorder that most commonly produces a stellate mass within the mesentery and should be differentiated from metastatic disease, specifically metastatic carcinoid, because it frequently responds to conservative or medical management.
  • Inflammatory pseudotumor (inflammatory myofibroblastic tumor) is a benign, chronic inflammatory disorder of unknown cause that manifests as a solid mesenteric mass, indistinguishable from malignancy.
  • Extrapleural solitary fibrous tumor is a tumor of submesothelial origin that is identical to the solitary fibrous tumor of the pleura.
  • When located in the mesentery or peritoneal cavity, extrapleural solitary fibrous tumor has an imaging pattern that must be differentiated from metastatic disease, soft-tissue sarcomas, and other benign and malignant neoplasms of the mesentery and peritoneum.
  • Knowledge of this group of benign fibrous tumors and tumorlike lesions of the mesentery is important in the preoperative evaluation of a mesenteric mass.
  • [MeSH-major] Mesentery. Peritoneal Diseases / diagnosis. Peritoneal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Child. Female. Fibroma / diagnosis. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Panniculitis, Peritoneal / diagnosis. Tomography, X-Ray Computed

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  • (PMID = 16418255.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 57
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67. Weiss ES, Burkart AL, Yeo CJ: Fibromatosis of the remnant pancreas after pylorus-preserving pancreaticoduodenectomy. J Gastrointest Surg; 2006 May;10(5):679-88
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  • [Title] Fibromatosis of the remnant pancreas after pylorus-preserving pancreaticoduodenectomy.
  • Intra-abdominal fibromatosis or desmoid tumors are rare forms of connective tissue cellular dysplasia characterized by proliferation of fibroblasts and abundant collagen.
  • Sporadic intra-abdominal desmoids involving the pancreas are quite rare, as only six previously reported cases exist.
  • In this report we present a seventh case of a sporadic intraabdominal desmoid involving the pancreas.
  • The patient, a 63-year-old white man, developed the desmoid tumor following a pylorus-preserving pancreaticoduodenectomy for an insulinoma.
  • Finally, we present a complete review of the six previous cases of sporadic pancreatic fibromatosis.
  • [MeSH-minor] Fibromatosis, Aggressive / pathology. Humans. Male. Middle Aged. Tomography, X-Ray Computed / methods

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  • (PMID = 16773761.001).
  • [ISSN] 1091-255X
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. González MA, Menéndez R, Ayala JM, Herrero M, Cuesta J, Domínguez A, Martínez M, Graña JL, Pozo F: [Intra-abdominal desmoid tumor]. Cir Esp; 2005 Jun;77(6):362-4
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  • [Title] [Intra-abdominal desmoid tumor].
  • [Transliterated title] Tumor desmoide intraabdominal.
  • Aggressive fibromatosis (desmoid tumor) are rare connective tissue tumors that occur sporadically or in association with familial adenomatous polyposis.
  • Biopsy is required to establish the diagnosis.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / surgery. Retroperitoneal Neoplasms / pathology. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16420952.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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69. Messiou C, Chalmers AG, Dexter S: An unusual case of ureteric obstruction. Br J Radiol; 2005 Sep;78(933):848-50
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  • We report a case of a 33-year-old female presenting with right sided abdominal pain, a right iliac fossa mass and right hydronephrosis.
  • The mass was subsequently shown to represent an isolated desmoid tumour compromising the adjacent ureter.
  • This is an uncommon occurrence and we discuss the imaging features and differential diagnosis.
  • [MeSH-major] Fibromatosis, Abdominal / complications. Hydronephrosis / etiology. Ureteral Obstruction / etiology

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  • (PMID = 16110110.001).
  • [ISSN] 0007-1285
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. Montagliani L, Duverger V: [Desmoid tumors]. J Chir (Paris); 2008 Jan-Feb;145(1):20-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Desmoid tumors].
  • Desmoid tumors are a rare form of malignancy with a great propensity for local extension and recurrence.
  • They typically occur in the abdominal wall or within the abdomen but also may occur extra-abdominally.
  • [MeSH-major] Fibromatosis, Abdominal / surgery. Fibromatosis, Aggressive / surgery. Mesentery. Peritoneal Neoplasms / surgery

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  • (PMID = 18438278.001).
  • [ISSN] 0021-7697
  • [Journal-full-title] Journal de chirurgie
  • [ISO-abbreviation] J Chir (Paris)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 29
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71. Solanki NS, Macfarlane PL, Marshall NJ: Images for surgeons. An extra-abdominal desmoid tumour in a young woman. ANZ J Surg; 2010 Oct;80(10):743-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Images for surgeons. An extra-abdominal desmoid tumour in a young woman.
  • [MeSH-major] Fibromatosis, Aggressive / pathology. Shoulder. Soft Tissue Neoplasms / pathology

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  • (PMID = 21061751.001).
  • [ISSN] 1445-2197
  • [Journal-full-title] ANZ journal of surgery
  • [ISO-abbreviation] ANZ J Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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72. Ioannou M, Demertzis N, Iakovidou I, Kottakis S: The role of imatinib mesylate in adjuvant therapy of extra-abdominal desmoid tumors. Anticancer Res; 2007 Mar-Apr;27(2):1143-7
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  • [Title] The role of imatinib mesylate in adjuvant therapy of extra-abdominal desmoid tumors.
  • BACKGROUND: Extra-abdominal desmoid tumors are rare neoplasms with variable biological behavior.
  • The purpose of this study was to determine the possible presence of tyrosine-kinase receptors in extra-abdominal desmoid tumors as a marker for imatinib mesylate therapy.
  • PATIENTS AND METHODS: From 1999 to 2004, immunohistochemical methods were carried-out in 14 patients with histologically confirmed extra-abdominal desmoid tumors to determine c-KIT positivity (existence of tyrosine-kinase receptors and PDGFRA and PDGFRB).
  • RESULTS: All desmoid tumors were c-KIT negative, which demonstrates absence of tyrosine-kinase receptors.
  • CONCLUSION: The histological c-KIT markup is an easy and reliable method that can detect whether a desmoid tumor is sensitive to additional treatment with a tyrosine-kinase receptor inhibitor.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Fibromatosis, Aggressive / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use

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  • (PMID = 17465254.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor beta
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73. Bertagnolli MM, Morgan JA, Fletcher CD, Raut CP, Dileo P, Gill RR, Demetri GD, George S: Multimodality treatment of mesenteric desmoid tumours. Eur J Cancer; 2008 Nov;44(16):2404-10
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  • [Title] Multimodality treatment of mesenteric desmoid tumours.
  • BACKGROUND: Desmoid tumours are rare neoplasms characterised by clonal proliferation of myofibroblasts that do not metastasise, but often exhibit an infiltrative pattern and functional impairment.
  • A multidisciplinary treatment plan was developed based on primary disease extent, tumour behaviour and resectability.
  • Patients with stable but unresectable disease were observed without treatment.
  • Patients with resectable disease underwent surgery, and patients with unresectable progressing disease received chemotherapy, most commonly liposomal doxorubicin, followed by surgery if chemotherapy rendered the disease resectable.
  • RESULTS: At a median follow-up of 50.0 months (range 4.6-212), 50 patients (96%) have either no recurrence or radiographically stable disease.
  • CONCLUSION: These data indicate that the extent of disease; tumour behaviour and resectability are the important factors when defining a treatment plan for mesenteric desmoid tumours.
  • A multidisciplinary approach of surgery combined with chemotherapy is an effective and function-sparing strategy for managing this disease.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Fibromatosis, Aggressive / drug therapy. Fibromatosis, Aggressive / surgery. Mesentery. Peritoneal Neoplasms / drug therapy. Peritoneal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Combined Modality Therapy. Doxorubicin / administration & dosage. Female. Fibromatosis, Abdominal / drug therapy. Fibromatosis, Abdominal / surgery. Humans. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Treatment Outcome. Vinblastine / administration & dosage. Vinblastine / analogs & derivatives. Young Adult

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  • (PMID = 18706807.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; Q6C979R91Y / vinorelbine
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74. Carlson JW, Fletcher CD: Immunohistochemistry for beta-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature. Histopathology; 2007 Oct;51(4):509-14
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  • [Title] Immunohistochemistry for beta-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature.
  • AIMS: Nuclear staining for beta-catenin by immunohistochemistry is being used increasingly to diagnose desmoid tumours (deep fibromatoses), especially where the differential diagnosis includes other abdominal spindle cell neoplasms.
  • This study aimed to define the prevalence of beta-catenin positivity in desmoid tumours and other morphologically similar spindle cell neoplasms.
  • Nuclear immunopositivity was detected in 80% of cases of sporadic desmoid fibromatosis (24/30) and in 67% of tumours in patients with familial adenomatous polyposis (8/12).
  • Nuclear positivity was also present in 14/25 superficial fibromatoses (56%), 3/10 low-grade myofibroblastic sarcomas (30%), 5/23 solitary fibrous tumours (22%), 1/5 infantile fibrosarcomas (20%), 1/18 desmoplastic fibroblastomas (6%) and 1/21 gastrointestinal stromal tumours (5%).
  • No nuclear immunoreactivity was present in neurofibromas (0/26), schwannomas (0/25), nodular fasciitis (0/19), leiomyosarcomas (0/16), inflammatory myofibroblastic tumours (0/12), fibromas of tendon sheath (0/9), lipofibromatoses (0/5), Gardner fibromas (0/4), calcifying aponeurotic fibromas (0/4) or fibromatosis colli (0/1).
  • CONCLUSION: Nuclear staining for beta-catenin is supportive, but not definitive, of the diagnosis of desmoid fibromatosis.
  • No significant difference in immunoreactivity was observed between sporadic and familial desmoid fibromatoses. beta-Catenin negativity does not preclude the diagnosis of fibromatosis.
  • [MeSH-major] Abdominal Neoplasms / chemistry. Sarcoma / chemistry. beta Catenin / analysis
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cell Nucleus / chemistry. Cell Nucleus / pathology. Diagnosis, Differential. Fibromatosis, Abdominal / diagnosis. Fibromatosis, Abdominal / pathology. Humans. Immunohistochemistry

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  • (PMID = 17711447.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / beta Catenin
  • [Number-of-references] 19
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75. Westmoreland SV, Mansfield KG: Comparative pathobiology of Kaposi sarcoma-associated herpesvirus and related primate rhadinoviruses. Comp Med; 2008 Feb;58(1):31-42
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  • Recently several new species-specific rhadinoviruses of Old World primates have been described, including retroperitoneal fibromatosis herpesvirus and rhesus rhadinovirus (Cercopithecine herpesvirus 17).
  • This review examines the comparative pathobiology of KSHV, discusses the role of macaque rhadinoviruses as models of human disease, and outlines the derivation of specific pathogen-free animals.

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  • (PMID = 19793454.001).
  • [ISSN] 1532-0820
  • [Journal-full-title] Comparative medicine
  • [ISO-abbreviation] Comp. Med.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / RR00168; United States / NCRR NIH HHS / RR / RR16020; United States / NCRR NIH HHS / RR / P51 RR000168; United States / NCRR NIH HHS / RR / K26 RR000168; United States / NCRR NIH HHS / RR / U42 RR016020
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interferon Regulatory Factor-1; 0 / Interferon Regulatory Factors; 0 / MicroRNAs; 0 / RNA, Viral; 0 / Viral Proteins; 0 / interferon regulatory factor-4
  • [Number-of-references] 93
  • [Other-IDs] NLM/ PMC2703163
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76. Collins D, Myers E, Kavanagh D, Lennon G, McDermott E: Mesenteric desmoid tumor causing ureteric obstruction. Int J Urol; 2008 Mar;15(3):261-2
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  • [Title] Mesenteric desmoid tumor causing ureteric obstruction.
  • Desmoid tumors are rare, accounting for just 0.03% of all neoplasms and less than 3% of all soft tissue tumors.
  • We describe the case of a 16-year-old female who presented with hydronephroureter secondary to an intra-abdominal desmoid tumor.
  • This case report draws the attention of urologists to the diagnostic dilemma and therapeutic challenges associated with an intra-abdominal mass causing ureteral obstruction especially in young patients.
  • [MeSH-major] Fibromatosis, Aggressive / complications. Mesentery. Peritoneal Neoplasms / complications. Ureteral Obstruction / etiology

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  • (PMID = 18304225.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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77. Meneu Díaz JC, Moreno González E, García García JI, Moreno A, Montejo JC, Colina F, Pérez B, Rodríguez S, Abradelos de Usera M, Garfia C, Fundora Y, Jiménez Galanes S, Lumbreras C, León M, Pérez Cerdá F, Solís-Herruzo JA: First Spanish series of intestinal transplantation in adult recipients. Rev Esp Enferm Dig; 2006 Oct;98(10):723-39
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  • RESULTS: to this date 5 transplants have been carried out in 4 patients (2 retransplants, 2 desmoid tumors, 1 short bowel syndrome after excision as a result of mesenteric ischemia).

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  • (PMID = 17094721.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Spain
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78. Bruce AG, Bakke AM, Bielefeldt-Ohmann H, Ryan JT, Thouless ME, Tsai CC, Rose TM: High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells. J Gen Virol; 2006 Dec;87(Pt 12):3529-38
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  • [Title] High levels of retroperitoneal fibromatosis (RF)-associated herpesvirus in RF lesions in macaques are associated with ORF73 LANA expression in spindleoid tumour cells.
  • In macaques, the RV1 lineage is represented by retroperitoneal fibromatosis (RF) herpesvirus (RFHV), the homologue of KSHV, whilst the RV2 lineage is represented by rhesus rhadinovirus (RRV), a more distantly related virus.
  • The RV1 loads were 220- to 4300-fold higher in RF tumours than in spleen, showing a strong tumour association (mean loads of 1 800 000 vs 2900 copies per 10(6) cells in tumours and spleen, respectively).
  • Immunostaining with antibodies reactive against RFHV ORF73 latency-associated nuclear antigen (LANA) showed intense nuclear staining of the spindleoid RF tumour cells.
  • Correlation of viral load and the number of LANA-positive cells indicated that RF tumour cells contained multiple copies of the RFHV genome per cell.
  • [MeSH-major] Antigens, Viral / biosynthesis. DNA, Viral / analysis. Herpesviridae Infections / virology. Nuclear Proteins / biosynthesis. Retroperitoneal Neoplasms / virology. Rhadinovirus / physiology. Simian Acquired Immunodeficiency Syndrome / complications. Tumor Virus Infections / virology
  • [MeSH-minor] Animals. Disease Models, Animal. Immunohistochemistry. Macaca mulatta. Macaca nemestrina. Polymerase Chain Reaction / methods. Spleen / virology. Statistics as Topic

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  • (PMID = 17098967.001).
  • [ISSN] 0022-1317
  • [Journal-full-title] The Journal of general virology
  • [ISO-abbreviation] J. Gen. Virol.
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / K02 AI49275; United States / NCRR NIH HHS / RR / RR00166; United States / NCRR NIH HHS / RR / RR13154
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Viral; 0 / DNA, Viral; 0 / Nuclear Proteins; 0 / latency-associated nuclear antigen
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79. Grouwels P, Verswijvel G, Vandevenne J, Palmers Y: Abdominal wall desmoid tumor. JBR-BTR; 2007 May-Jun;90(3):190-1
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abdominal wall desmoid tumor.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Fibroma / diagnosis

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  • (PMID = 17696091.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Contrast Media
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80. Lund H, Ekvall BF: [Mesenteric fibromatosis]. Ugeskr Laeger; 2009 Nov 23;171(48):3539-40
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  • [Title] [Mesenteric fibromatosis].
  • [Transliterated title] Mesenteriel fibromatose.
  • Mesenterial fibromatosis is a benign proliferating neoplasia that originates from the mesenterium or retroperitoneum.
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Intestine, Small / pathology. Mesentery. Neoplasm Recurrence, Local

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  • (PMID = 19944057.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Denmark
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81. Rifaat MA, Abdel Gawad WS: The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation. J Egypt Natl Canc Inst; 2005 Sep;17(3):139-48
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  • [Title] The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation.
  • As a pedicled flap its reach to the lower abdomen and groin made it an attractive option for reconstructing soft tissue defects after tumor ablation.
  • Also, the adequacy of the fascia lata as a sole substitute for abdominal wall muscles has been disputable.
  • PATIENTS AND METHODS: From April 2001 to April 2004, 12 pedicled TFL flaps were used to reconstruct 5 central abdominal wall full thickness defects and 6 groin soft tissue defects following tumor resection.
  • In one case, bilateral flaps were used to reconstruct a large central abdominal wall defect.
  • From the abdominal wall defects group, all repairs were enforced primarily with a prolene mesh except for one patient who was the first in this study.
  • Patients presenting with groin defects required coverage of exposed vessels following tumor resection.
  • RESULTS: The resulting soft tissue defects in this study were due to resection of 4 abdominal wall desmoid tumors, a colonic carcinoma infiltrating the abdominal wall, 4 primary groin soft tissue sarcomas, a metastatic SCC of the leg to groin nodes, and a primary SCC of the groin.
  • Three of those cases developed in flaps reconstructing abdominal wall defects, and one case developed in a flap used to cover a groin defect.
  • Out of the 5 cases that underwent abdominal wall reconstruction, one case developed ventral hernia, in which bilateral TFL flaps were used without mesh enforcement.
  • Only one patient died of distant metastasis of a SCC of the groin skin, 8 months postoperatively and another 2 patients with abdominal desmoid tumors developed local recurrence.
  • A pedicled flap would be appropriate for lower abdominal wall defects, and is better islanded to achieve extra mobilization and allow a tension free closure, while for groin defects, simple flap transposition should be enough.
  • Nevertheless, reconstruction for full thickness abdominal wall defects by this flap is a static reconstruction.
  • [MeSH-major] Abdominal Wall / surgery. Groin / surgery. Neoplasms / surgery. Surgical Flaps
  • [MeSH-minor] Abdominal Neoplasms / surgery. Adult. Fascia Lata. Female. Humans. Male. Middle Aged. Reconstructive Surgical Procedures

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  • (PMID = 16799651.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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82. Tanaka K, Yoshikawa R, Yanagi H, Gega M, Fujiwara Y, Hashimoto-Tamaoki T, Hirota S, Tsujimura T, Tomita N: Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug. World J Surg Oncol; 2008;6:17
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  • [Title] Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug.
  • BACKGROUND: Desmoid tumours or fibromatoses are rare entities characterized by the benign proliferation of fibroblasts, which can be life-threatening due to their locally aggressive properties.
  • Surgery is widely accepted as the first line of treatment for extra-abdominal desmoids; however, it is not recommended for intra-abdominal desmoids because of the high-risk of recurrence and difficulties with the operation.
  • Here, we report on a patient with sporadic intra-abdominal desmoid tumours, who showed partial response following the intake of non-steroidal anti-inflammatory drugs.
  • Computed tomography showed an abnormal multilocular soft-tissue mass (95 x 70 mm) in the right pelvis, which was revealed by biopsy to be a desmoid tumour.
  • Immunohistochemical analysis showed that the tumour cells expressed vimentin, but not smooth-muscle actin, CD34, or desmin.
  • Two years after the commencement of non-steroidal anti-inflammatory drug administration, computed tomography showed a decrease in tumour size (63 x 49 mm), and the disappearance of intratumoural septa.
  • CONCLUSION: Our case report suggests that non-steroidal anti-inflammatory drug treatment should be taken into consideration for use as first-line treatment in patients with sporadic intra-abdominal desmoid tumours.
  • [MeSH-major] Abdominal Neoplasms / drug therapy. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Fibromatosis, Abdominal / drug therapy. Fibromatosis, Aggressive / drug therapy

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  • (PMID = 18257933.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal
  • [Other-IDs] NLM/ PMC2270274
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83. Church J, Berk T, Boman BM, Guillem J, Lynch C, Lynch P, Rodriguez-Bigas M, Rusin L, Weber T, Collaborative Group of the Americas on Inherited Colorectal Cancer: Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for a uniform approach to a troubling disease. Dis Colon Rectum; 2005 Aug;48(8):1528-34
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  • [Title] Staging intra-abdominal desmoid tumors in familial adenomatous polyposis: a search for a uniform approach to a troubling disease.
  • INTRODUCTION: Desmoid tumors are a clinical problem in 12 to 15 percent of patients with familial adenomatous polyposis.
  • There is no predictably effective treatment for intra-abdominal desmoid tumors, which sometimes cause significant complications by their effects on the ureters or bowel.
  • The relative rarity and the clinical heterogeneity of intra-abdominal desmoid tumors make randomized studies difficult to do.
  • METHODS: Intra-abdominal desmoid tumors can be staged according to their size, clinical presentation and growth pattern.
  • CONCLUSION: A way of staging intra-abdominal desmoid tumors is proposed to facilitate stratification by disease severity during collaborative studies of various treatments.
  • [MeSH-major] Abdominal Neoplasms / pathology. Adenomatous Polyposis Coli / pathology. Fibromatosis, Aggressive / pathology. Neoplasms, Multiple Primary / pathology
  • [MeSH-minor] Abdominal Wall / pathology. Clinical Protocols. Genes, APC. Genotype. Humans. Mesentery / pathology. Mutation / genetics. Neoplasm Staging. Patient Care Planning. Peritoneal Neoplasms / pathology. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis

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  • (PMID = 15906134.001).
  • [ISSN] 0012-3706
  • [Journal-full-title] Diseases of the colon and rectum
  • [ISO-abbreviation] Dis. Colon Rectum
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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84. Teo HE, Peh WC, Shek TW: Case 84: desmoid tumor of the abdominal wall. Radiology; 2005 Jul;236(1):81-4
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  • [Title] Case 84: desmoid tumor of the abdominal wall.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 15987965.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Seinfeld J, Kleinschmidt-DeMasters BK, Tayal S, Lillehei KO: Desmoid-type fibromatosis involving the brachial plexus. Neurosurg Focus; 2007;22(6):E22
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  • [Title] Desmoid-type fibromatosis involving the brachial plexus.
  • Desmoid-type fibromatosis involving the brachial plexus is a rare and challenging disease.
  • The authors describe their experience in four surgically treated patients with desmoid-type fibromatosis involving the brachial plexus and review the relevant neurosurgical literature.
  • Three patients experienced tumor recurrence requiring reoperation.
  • Fractionated radiotherapy achieved local control in three patients, and the disease in one patient progressed beyond the treatment field.
  • One tumor with this mutation did not respond to treatment with imatimib mesylate.
  • Analysis of these cases emphasizes the need for careful resection in patients with desmoid-type fibromatosis and supports the conclusion that without adjuvant radiotherapy a high local recurrence rate can be anticipated.
  • For optimal local disease control, the authors recommend postsurgical radiation therapy regardless of the extent of resection achieved.
  • [MeSH-major] Brachial Plexus / pathology. Brachial Plexus / surgery. Fibromatosis, Abdominal / radiotherapy. Fibromatosis, Abdominal / surgery
  • [MeSH-minor] Adult. Aged. Female. Fibromatosis, Aggressive / diagnosis. Fibromatosis, Aggressive / radiotherapy. Fibromatosis, Aggressive / surgery. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17613214.001).
  • [ISSN] 1092-0684
  • [Journal-full-title] Neurosurgical focus
  • [ISO-abbreviation] Neurosurg Focus
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Speake D, Evans DG, Lalloo F, Scott NA, Hill J: Desmoid tumours in patients with familial adenomatous polyposis and desmoid region adenomatous polyposis coli mutations. Br J Surg; 2007 Aug;94(8):1009-13
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  • [Title] Desmoid tumours in patients with familial adenomatous polyposis and desmoid region adenomatous polyposis coli mutations.
  • BACKGROUND: :The aim of this study was to determine the proportion of patients with familial adenomatous polyposis (FAP) who had mutations in the desmoid region of the adenomatous polyposis coli (APC) gene that phenotypically expresses desmoid disease, and to determine the role for surgery in these patients.
  • RESULTS: Of 363 patients with FAP, 47 from ten families had APC mutations in the desmoid region 3' to codon 1399.
  • Of 22 patients undergoing surgery, 16 developed desmoids, and of these 12 had mesenteric desmoid disease.
  • Complications from mesenteric desmoids were death (two patients), enterectomy (three), local resection (three), fistula (one), cholangitis and local resection (one), bowel obstruction (one) and bowel and ureteric obstruction (one).
  • CONCLUSION: In individuals with 3' APC mutations, abdominal surgery is associated with a 65 per cent risk of developing mesenteric desmoids.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Fibromatosis, Aggressive / genetics. Genes, APC. Mesentery. Mutation / genetics. Peritoneal Neoplasms / genetics

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  • [Copyright] Copyright (c) 2007 British Journal of Surgery Society Ltd.
  • (PMID = 17410559.001).
  • [ISSN] 0007-1323
  • [Journal-full-title] The British journal of surgery
  • [ISO-abbreviation] Br J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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87. Baumert BG, Spahr MO, Von Hochstetter A, Beauvois S, Landmann C, Fridrich K, Villà S, Kirschner MJ, Storme G, Thum P, Streuli HK, Lombriser N, Maurer R, Ries G, Bleher EA, Willi A, Allemann J, Buehler U, Blessing H, Luetolf UM, Davis JB, Seifert B, Infanger M: The impact of radiotherapy in the treatment of desmoid tumours. An international survey of 110 patients. A study of the Rare Cancer Network. Radiat Oncol; 2007;2:12
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  • [Title] The impact of radiotherapy in the treatment of desmoid tumours. An international survey of 110 patients. A study of the Rare Cancer Network.
  • PURPOSE: A multi-centre study to assess the value of combined surgical resection and radiotherapy for the treatment of desmoid tumours.
  • A comparison of PFS for tumour locations proved the abdominal wall to be a positive prognostic factor and a localization in the extremities to be a negative prognostic factor.
  • Additional irradiation, a fraction size larger than or equal to 2 Gy and a total dose larger than 50 Gy to the tumour were found to be positive prognostic factors with a significantly lower risk for a recurrence in the univariate analysis.
  • Therefore it should always be considered after a non-radical tumour resection and should be given preferably in an adjuvant setting.
  • [MeSH-major] Fibromatosis, Aggressive / radiotherapy. Fibromatosis, Aggressive / surgery. Radiotherapy / methods. Soft Tissue Neoplasms / radiotherapy. Soft Tissue Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Child, Preschool. Combined Modality Therapy. Disease-Free Survival. Europe. Humans. Infant. Middle Aged. Recurrence. Time Factors

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  • (PMID = 17343751.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1828737
  • [General-notes] NLM/ Original DateCompleted: 20070810
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88. Pencavel T, Strauss DC, Thomas JM, Hayes AJ: The surgical management of soft tissue tumours arising in the abdominal wall. Eur J Surg Oncol; 2010 May;36(5):489-95
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  • [Title] The surgical management of soft tissue tumours arising in the abdominal wall.
  • BACKGROUND: Soft-tissue tumours can occur at almost any site, including the abdominal wall and represent a biologically diverse group of benign and malignant tumours.
  • METHODS: A prospectively-kept database was searched to identify all patients with tumours resected that involved the abdominal wall.
  • The histological diagnosis, complication rates and local recurrence rates were reported.
  • Kaplan-Meier analysis of prognostic factors was determined for patients with primary abdominal wall sarcomas.
  • RESULTS: Ninety-two patients underwent resection for tumours involving the abdominal wall.
  • Desmoid tumours (n=30) and primary soft-tissue sarcomas (n=25) were the most common pathologies.
  • Of 92 patients undergoing resection 87 required reconstruction of the abdominal wall defect with polypropelene mesh but only 2 patients required reconstruction of the overlying skin.
  • There were no immediate surgical complications in patients who underwent isolated abdominal wall reconstruction and the long term incision hernia rate was 4%.
  • Kaplan-Meier analysis for patients with primary abdominal wall sarcomas showed that local recurrence was higher in tumours>10cm (p=0.0024) and in high grade tumours (p=0.0021).
  • Disease-specific survival was worst in high grade tumours (p=0.0010) and tumours>10cm (p=0.0042).
  • Desmoid tumours did not recur in any patient after abdominal wall resection, irrespective of microscopic margins.
  • CONCLUSIONS: Tumours involving the abdominal wall exhibit a wide range of pathologies.
  • Abdominal wall reconstruction can be achieved in the vast majority of cases with mesh reconstruction alone with little surgical morbidity.
  • Abdominal wall fibromatosis carries a better prognosis than fibromatosis arising in the extremities.
  • [MeSH-major] Abdominal Wall / surgery. Neoplasm Recurrence, Local. Sarcoma / surgery

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20381991.001).
  • [ISSN] 1532-2157
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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89. Rajakannu M, Ananthakrishnan N, Madhavan M: Isolated mesenteric fibromatosis. Trop Gastroenterol; 2008 Jul-Sep;29(3):179-80
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  • [Title] Isolated mesenteric fibromatosis.
  • Fibromatosis is a rare, locally aggressive but non-metastasising fibrous mass often associated with familial adenomatous polyposis in Gardner's Syndrome (GS).
  • Although sporadic cases occur, unlike in GS, they are predominantly extra-abdominal.
  • We report the case of a 40-year-old lady who underwent laparotomy for a large isolated abdominal mass three years after a Whipple's procedure for adenocarcinoma of the distal common bile duct.
  • A spherical, football sized tumour was found in the jejunal mesentery.
  • Resection of the tumour with jejunum was carried out.
  • This case is peculiar in that mesenteric fibromatosis occurred in a patient with prior history of periampullary carcinoma and without history of familial adenomatous polyposis.
  • [MeSH-major] Fibroma / diagnosis. Jejunal Neoplasms / diagnosis

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  • (PMID = 19115615.001).
  • [ISSN] 0250-636X
  • [Journal-full-title] Tropical gastroenterology : official journal of the Digestive Diseases Foundation
  • [ISO-abbreviation] Trop Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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90. Dalén BP, Geijer M, Kvist H, Bergh PM, Gunterberg BU: Clinical and imaging observations of desmoid tumors left without treatment. Acta Orthop; 2006 Dec;77(6):932-7
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  • [Title] Clinical and imaging observations of desmoid tumors left without treatment.
  • BACKGROUND: Until now, surgical treatment has been the mainstay in the treatment of desmoid tumors, even though it is associated with a high recurrence rate.
  • There have, however, been occasional case reports showing that desmoid tumors may spontaneously decrease in size or even disappear.
  • PATIENTS AND METHODS: This is a retrospective review of 8 patients with abdominal (5) or extra-abdominal (3) desmoid tumors who were followed both clinically and with imaging techniques (sonography, CT or MRI).
  • Tumor volume was assessed in each investigation and followed over time.
  • INTERPRETATION: Desmoid tumors have probably been overtreated in the past.
  • [MeSH-major] Fibromatosis, Abdominal / diagnosis. Fibromatosis, Aggressive / diagnosis. Neoplasm Regression, Spontaneous. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 17260204.001).
  • [ISSN] 1745-3674
  • [Journal-full-title] Acta orthopaedica
  • [ISO-abbreviation] Acta Orthop
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Sweden
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91. Murphey MD, Ruble CM, Tyszko SM, Zbojniewicz AM, Potter BK, Miettinen M: From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics; 2009 Nov;29(7):2143-73
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  • [Title] From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation.
  • Musculoskeletal fibromatoses represent a wide spectrum of fibroblastic and myofibroblastic neoplasms with similar pathologic appearances and variable clinical behavior.
  • Superficial fibromatoses in adults (palmar and plantar) and children (calcifying aponeurotic fibroma, lipofibromatosis, and inclusion body fibromatosis) are often small slow-growing lesions; their diagnosis is suggested by location.
  • Deep fibromatoses in adults (desmoid type and abdominal wall) and children (fibromatosis colli and myofibroma and myofibromatosis) are frequently large and more rapidly enlarging; location of these lesions may be nonspecific.
  • MR imaging findings of predominantly low to intermediate signal intensity, nonenhancing bands of low signal intensity on long repetition time MR images that represent collagenized regions, and extension along fascial planes ("fascial tail" sign) add specificity for diagnosis.
  • Additional features that aid in diagnostic specificity include an abdominal wall location related to pregnancy (abdominal wall fibromatosis), a lower neck location in a young child (fibromatosis colli), an adipose component (lipofibromatosis), or multiple lesions in young children (myofibromatosis).
  • Treatment may be conservative or surgical resection, depending on the specific diagnosis.
  • Recognition that the appearances of the various types of musculoskeletal fibromatoses reflect their pathologic characteristics improves radiologic assessment and helps optimize patient management.
  • [MeSH-major] Bone Diseases / diagnosis. Fibroma / diagnosis. Magnetic Resonance Imaging. Muscular Diseases / diagnosis

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  • (PMID = 19926768.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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92. Soravia C, DeLozier CD, Dobbie Z, Berthod CR, Arrigoni E, Bründler MA, Blouin JL, Foulkes WD, Hutter P: Double frameshift mutations in APC and MSH2 in the same individual. Int J Colorectal Dis; 2006 Jan;21(1):79-83
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The number of polyps (less than ten) was not typical of polyposis; therefore, the diagnosis of HNPCC was entertained.
  • The tumor tissue showed high-grade instability, and a subsequent, immunohistochemistry showed that neither MSH2 nor MSH6 proteins were expressed in tumor cells.
  • The patient later developed an intra-abdominal desmoid tumor.
  • [MeSH-major] Adenomatous Polyposis Coli / genetics. Colorectal Neoplasms, Hereditary Nonpolyposis / genetics. Frameshift Mutation. Genes, APC. Genetic Predisposition to Disease. MutS Homolog 2 Protein / genetics
  • [MeSH-minor] Adult. Colectomy. Diagnosis, Differential. Germ-Line Mutation. Humans. Male. Pedigree

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  • [RepublishedFrom] Int J Colorectal Dis. 2005 Sep;20(5):466-470 [15834612.001]
  • (PMID = 16676398.001).
  • [ISSN] 0179-1958
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Case Reports; Corrected and Republished Article; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 3.6.1.3 / MSH2 protein, human; EC 3.6.1.3 / MutS Homolog 2 Protein
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93. Ayhan S, Temız P, Kurt K: Mesenteric fibromatosis: a case report. Turk J Gastroenterol; 2010 Jun;21(2):193-5
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  • [Title] Mesenteric fibromatosis: a case report.

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  • (PMID = 20872340.001).
  • [ISSN] 2148-5607
  • [Journal-full-title] The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • [ISO-abbreviation] Turk J Gastroenterol
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Turkey
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94. Joyner DE, Trang SH, Aboulafia AJ, Damron TA, Randall RL: FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin. Fam Cancer; 2009;8(4):569-80
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  • [Title] FAP-associated desmoid invasiveness correlates with in vitro resistance to doxorubicin.
  • Desmoid tumors are locally invasive myofibroblastic lesions that arise predominantly in the abdominal wall or shoulder girdle and are prone to aggressive local recurrences without metastases.
  • We hypothesized the intrinsic invasiveness and drug resistance displayed by cells derived from a familial adenomatous polyposis (FAP)-associated desmoid tumor would surpass the response shown by cells derived from sporadic desmoid tumors.
  • FAP-associated tumor cells were significantly more invasive and refractory to doxorubicin than were cells extracted from sporadic tumors.
  • Pro-MMP1 protein predominated over MMP3 in FAP-associated cell culture supernatants, while MMP3 was the dominant antigen in sporadic tumor cell supernatants.
  • Three genes associated with apoptosis were identified by microarray, two prosurvival genes overexpressed in FAP-associated cell cultures (NTN1, TNFRSF10C) and one proapoptosis gene overexpressed in sporadic tumor cell cultures (FOXL2).
  • [MeSH-major] Adenomatous Polyposis Coli / pathology. Antineoplastic Agents / pharmacology. Doxorubicin / pharmacology. Drug Resistance, Neoplasm / genetics. Fibromatosis, Aggressive / pathology. Neoplasm Invasiveness / pathology
  • [MeSH-minor] Adolescent. Adult. Apoptosis / genetics. Cell Line, Tumor. Enzyme-Linked Immunosorbent Assay. Female. Gene Expression / drug effects. Humans. Male. Matrix Metalloproteinase 1 / metabolism. Matrix Metalloproteinase 3 / metabolism. Oligonucleotide Array Sequence Analysis. Reverse Transcriptase Polymerase Chain Reaction

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  • [ErratumIn] Fam Cancer. 2010 Jun;9(2):261. Randall, R Lor [corrected to Randall, R L]
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  • (PMID = 19728161.001).
  • [ISSN] 1573-7292
  • [Journal-full-title] Familial cancer
  • [ISO-abbreviation] Fam. Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P30CA042014
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 80168379AG / Doxorubicin; EC 3.4.24.17 / Matrix Metalloproteinase 3; EC 3.4.24.7 / Matrix Metalloproteinase 1
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95. Chattopadhyay A, Biswas SK, Dutta M: Pedicled omental split skin graft: A novel method for reconstruction of full-thickness abdominal wall defect. J Indian Assoc Pediatr Surg; 2010 Oct;15(4):142-4
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  • [Title] Pedicled omental split skin graft: A novel method for reconstruction of full-thickness abdominal wall defect.
  • Although rare in children, aggressive fibromatosis or desmoid tumors require wide surgical excision for durable relief.
  • The authors report reconstruction of such a wound using a pedicled omental split skin graft, which resulted from the excision of a locally recurrent desmoid tumor.

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  • (PMID = 21170199.001).
  • [ISSN] 1998-3891
  • [Journal-full-title] Journal of Indian Association of Pediatric Surgeons
  • [ISO-abbreviation] J Indian Assoc Pediatr Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2995941
  • [Keywords] NOTNLM ; Abdominal wall defect / aggressive fibromatosis / desmoid tumor / pedicled omental split skin graft
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96. Ballardini P, Gulmini L, Margutti G, Lelli G: Mesenteric fibromatosis in a patient with Camurati-Engelmann disease. A case report and literature review. Tumori; 2005 Nov-Dec;91(6):552-4
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  • [Title] Mesenteric fibromatosis in a patient with Camurati-Engelmann disease. A case report and literature review.
  • Mesenteric fibromatosis is a rare type of desmoid tumor characterized by local aggressiveness and a tendency to relapse.
  • Camurati-Engelmann disease is a very rare form of bone dysplasia characterized by osteosclerosis of the diaphyses of the long bones.
  • Here we describe the case of a male patient affected by these two rare diseases in association with chronic inflammatory intestinal disease.


97. Kourda N, Ben Slama S, Mrabet N, Sayari S, Zouache A, Ben Jilani SB, Zermani R: [Abdominal desmoid tumor: pathologic and therapeutic concepts]. Tunis Med; 2008 Oct;86(10):916-20
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  • [Title] [Abdominal desmoid tumor: pathologic and therapeutic concepts].
  • [Transliterated title] Tumeur desmoide abdominale: concepts histopathologiques et therapeutiques.
  • BACKGROUND: Abdominal desmoid tumors arise in young adults between 20 and 40 years.
  • METHODS: From 1990 to 2004, three cases of abdominal desmoid tumors were diagnosed in the Pathologic laboratory of the Charles Nicole Hospital of Tunis.
  • CONCLUSION: Abdominal desmoid tumors are locally aggressive but never give metastasis.
  • [MeSH-major] Abdominal Neoplasms / pathology. Abdominal Neoplasms / therapy. Fibromatosis, Aggressive / pathology. Fibromatosis, Aggressive / therapy

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  • (PMID = 19472812.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Tunisia
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98. Bruce AG, Bakke AM, Thouless ME, Rose TM: Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons. Virol J; 2005 Jan 05;2:2
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  • These primers showed little similarity to the corresponding sequences of the macaque RV1 rhadinoviruses, retroperitoneal fibromatosis herpesvirus Macaca nemestrina (RFHVMn) and Macaca mulatta (RFHVMm).

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  • (PMID = 15634356.001).
  • [ISSN] 1743-422X
  • [Journal-full-title] Virology journal
  • [ISO-abbreviation] Virol. J.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / RR13154; United States / NCRR NIH HHS / RR / P51 RR000166; United States / NCRR NIH HHS / RR / R24 RR023343; United States / NIAID NIH HHS / AI / K02 AI49275; United States / NCRR NIH HHS / RR / R01 RR013154; United States / NIAID NIH HHS / AI / K02 AI049275; United States / NCRR NIH HHS / RR / RR00166
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC544863
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99. Dalal AK, Singal R, Dalal U, Attri AK, Sahu P, Gupta A: An unusual case of chest wall desmoid tumor. Indian J Surg; 2010 Jul;72(Suppl 1):336-8
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  • [Title] An unusual case of chest wall desmoid tumor.
  • Desmoid tumor of the chest wall are uncommon fibromatous tumors characterized by their local invasion and frequent recurrences.
  • Extra-abdominal sites are mainly the shoulder girdle, the pelvic girdle and distal ends of the lower limbs.
  • The chest wall represents 8-10% of cases and the tumor is exceptionally intrathoracic.
  • We present here a rare case of a large desmoid tumor of left antero-lateral chest wall.
  • In the presented case, wide excision of the tumor and chest wall reconstruction was done.

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  • (PMID = 23133290.001).
  • [ISSN] 0972-2068
  • [Journal-full-title] The Indian journal of surgery
  • [ISO-abbreviation] Indian J Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451859
  • [Keywords] NOTNLM ; Chest wall / Extra abdominal tumor / Surgery
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100. Church J, Lynch C, Neary P, LaGuardia L, Elayi E: A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis. Dis Colon Rectum; 2008 Jun;51(6):897-901
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  • [Title] A desmoid tumor-staging system separates patients with intra-abdominal, familial adenomatous polyposis-associated desmoid disease by behavior and prognosis.
  • PURPOSE: Intra-abdominal desmoid tumors associated with familial adenomatous polyposis are heterogeneous.
  • Eight patients with Stage I disease received medical treatment, as did 26 with Stage II, 16 with Stage III, and 15 with Stage IV.
  • Chemotherapy was given to 1 Stage II tumor, 7 Stage III, and 5 Stage IV.
  • No patient with Stages I or II disease died.
  • Finally 89 percent with Stage I, 65 percent with Stage II, 59 percent with Stage III, and 50 percent with Stage IV disease were asymptomatic; 81 percent of Stage I desmoids, 78 percent of Stage II, 42 percent of Stage III, and 28 percent of Stage IV were stable or disappeared.
  • CONCLUSION: Desmoid staging identifies tumors by prognosis and its use for designing prospective treatment studies is reasonable.
  • [MeSH-major] Adenomatous Polyposis Coli / complications. Fibromatosis, Abdominal / pathology. Fibromatosis, Aggressive / pathology. Neoplasm Staging / methods






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