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1. Quattrocchi CC, Santini D, Dell'aia P, Piciucchi S, Leoncini E, Vincenzi B, Grasso RF, Tonini G, Zobel BB: A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid. Skeletal Radiol; 2007 Dec;36(12):1121-7
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  • All patients underwent CT of the chest, abdomen, and pelvis.
  • CONCLUSION: Bone density measured by CT increases at metastatic sites after zoledronic acid treatment, regardless of the type of metastasis, in contrast to apparently normal bone.

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  • (PMID = 17912514.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Contrast Media; 0 / Diphosphonates; 0 / Imidazoles; 182ECH14UH / iobitridol; 4419T9MX03 / Iohexol; 6XC1PAD3KF / zoledronic acid
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2. Martin RC, Scoggins CR, McMasters KM: Microwave hepatic ablation: initial experience of safety and efficacy. J Surg Oncol; 2007 Nov 1;96(6):481-6
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  • Tumor types, metastatic colorectal cancer (n = 9), hepatocellular (n = 5), metastatic carcinoid (n = 2), and one patient each with metastatic ovarian, breast, and gastric.
  • The overall ablation success at the discharge CT of the abdomen was 100%.

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  • (PMID = 17654527.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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3. Islam T, Harisinghani MG: Overview of nanoparticle use in cancer imaging. Cancer Biomark; 2009;5(2):61-7
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  • [Title] Overview of nanoparticle use in cancer imaging.
  • Current cross-sectional imaging modalities are inaccurate in characterizing nodal metastatic disease because of their use of size and/or morphology as differentiating factors.
  • Ferumoxtran-10-enhanced MRI offers higher diagnostic precision than unenhanced MRI and is sensitive and specific for the detection of lymph-node metastases, especially in malignant diseases of the abdomen and pelvis.

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  • (PMID = 19414922.001).
  • [ISSN] 1574-0153
  • [Journal-full-title] Cancer biomarkers : section A of Disease markers
  • [ISO-abbreviation] Cancer Biomark
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Magnetite Nanoparticles; 0 / Oxides; 0 / ferumoxtran-10; E1UOL152H7 / Iron; K3R6ZDH4DU / Dextrans; XM0M87F357 / Ferrosoferric Oxide
  • [Number-of-references] 57
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4. Lee DK: Prostate cancer metastases to the leg, ankle, and foot. J Am Podiatr Med Assoc; 2008 May-Jun;98(3):242-5
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  • [Title] Prostate cancer metastases to the leg, ankle, and foot.
  • Metastases to the bones of the lower extremities from prostate carcinomas are rare and are usually associated with diffuse metastatic disease or primary tumors of the abdomen and lungs.

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  • (PMID = 18487599.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Ambika S, Melton A, Lee D, Hesketh PJ: Massive retroperitoneal adrenal hemorrhage secondary to lung cancer metastasis treated by adrenal artery embolization. Clin Lung Cancer; 2009 Sep;10(5):E1-4
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  • [Title] Massive retroperitoneal adrenal hemorrhage secondary to lung cancer metastasis treated by adrenal artery embolization.
  • The development of adrenal hemorrhage from lung cancer metastasis is extremely rare.
  • A 54-year-old woman with stage IV non-small-cell lung cancer and known bilateral adrenal metastasis developed severe right-sided abdominal pain while undergoing chemotherapy treatment.
  • A computerized tomography scan of the abdomen with intravenous contrast demonstrated massive right-sided retroperitoneal hemorrhage.
  • TCE can be used to control hemorrhage arising from metastatic involvement of the adrenal gland.


6. Syryło T, Syryło A, Jurkiewicz D, Zieliński H, Pietka T: An upper lip tumour as the presenting symptom of metastatic renal cancer. Otolaryngol Pol; 2010 Sep-Oct;64(5):318-9
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  • [Title] An upper lip tumour as the presenting symptom of metastatic renal cancer.
  • Unfortunately, in spite of continuous development of more and more efficient diagnostic methods, in about 30% of patients with RCC metastatic spread is found at presentation.
  • We present a case of a male patient in whom a tumour of the upper lip was the first symptom of advanced renal cancer.
  • A CT scan of the chest and abdomen showed a large tumour of the kidney, multiple lung and bone metastases.
  • CONCLUSIONS: In natural history of renal cancer there is a risk of metastatic spread to the head-and-neck region.
  • Contrast enhanced computed tomography of the abdomen should be considered if a tumour of unknown origin is found within the head-and-neck region.
  • Prognosis in case of confirmed metastatic renal cancer is unfavourable and patient's treatment should be conducted in specialist centres.

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  • (PMID = 21162343.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
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7. Lim KH, Lee KW, Kim JH, Park SY, Choi SH, Lee JS: Anaplastic thyroid carcinoma initially presented with abdominal cutaneous mass and hyperthyroidism. Korean J Intern Med; 2010 Dec;25(4):450-3
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  • Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC.
  • [MeSH-minor] Abdomen. Female. Humans. Middle Aged. Thyroid Carcinoma, Anaplastic. Thyroid Neoplasms / pathology

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  • (PMID = 21179285.001).
  • [ISSN] 1226-3303
  • [Journal-full-title] The Korean journal of internal medicine
  • [ISO-abbreviation] Korean J. Intern. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2997976
  • [Keywords] NOTNLM ; Anaplastic carcinoma / Cutaneous metastasis / Hyperthyroidism / Thyroid neoplasms
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8. Choueiri TK, Dreicer R, Paciorek A, Carroll PR, Konety B: A model that predicts the probability of positive imaging in prostate cancer cases with biochemical failure after initial definitive local therapy. J Urol; 2008 Mar;179(3):906-10; discussion 910
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A model that predicts the probability of positive imaging in prostate cancer cases with biochemical failure after initial definitive local therapy.
  • PURPOSE: Managing biochemical failure in patients following initial treatment of localized prostate cancer is a relatively common clinical problem.
  • Imaging studies to document metastatic disease are frequently obtained but are often uninformative.
  • MATERIALS AND METHODS: From CaPSURE, a national disease registry, all patients with a detectable prostate specific antigen after definitive therapy with radical prostatectomy or radiation therapy and who had undergone at least 1 imaging study (bone scan, computerized tomography or magnetic resonance imaging of the abdomen and pelvis) were identified.


9. Gencosmanoglu R, Aker F, Kir G, Tozun N: Isolated metachronous splenic metastasis from synchronous colon cancer. World J Surg Oncol; 2006;4:42
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  • [Title] Isolated metachronous splenic metastasis from synchronous colon cancer.
  • BACKGROUND: Isolated splenic metastases from colorectal cancer are very rare and there are only 13 cases reported in the English literature so far.
  • However, a gradually rising CEA level after the 14th postoperative month necessitated further imaging studies including computed tomography of the abdomen which revealed a mass in the spleen that was subsequently confirmed by 18FDG- PET scanning to be an isolated metastasis.
  • The patient underwent splenectomy 17 months after his previous cancer surgery.
  • Histological diagnosis confirmed a metastatic adenocarcinoma with no capsule invasion.
  • CONCLUSION: Isolated splenic metastasis is a rare finding in the follow-up of colorectal cancer patients and long-term survival can be achieved with splenectomy.

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  • (PMID = 16824207.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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10. Sawyer A, McGoldrick RB, Mackey SP, Allan R, Powell B: Does staging computered tomography change management in thick malignant melanoma? J Plast Reconstr Aesthet Surg; 2009 Apr;62(4):453-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Currently UK guidelines for the management of cutaneous melanoma at intermediate or high risk of recurrent disease (American Joint Cancer Committee) AJCC IIB disease or worse (Breslow 2.01-4.0mm with ulceration or Breslow >4mm) should have the following staging investigations: chest X-ray; liver ultrasonography or computed tomographic (CT) scan with intravenous contrast enhancement of chest, abdomen and pelvis; liver function tests; lactate dehydrogenase and full blood count.
  • All of these patients exhibited symptoms and signs of clinical metastatic disease.
  • Head metastases are at least as common as other regions such as the chest & abdomen and more common than in the pelvis.
  • CONCLUSION: CT staging for cutaneous melanoma is not indicated unless there are signs or symptoms of metastatic disease.
  • If there are symptoms and signs of metastatic disease than patients should be staged and we advocate that staging of AJCC IIB/C should include imaging of the head in addition to chest, abdomen and pelvis.

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  • (PMID = 18468970.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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11. Kosmider S, Stella DL, Field K, Moore M, Ananda S, Oakman C, Singh M, Gibbs P: Preoperative investigations for metastatic staging of colon and rectal cancer across multiple centres--what is current practice? Colorectal Dis; 2009 Jul;11(6):592-600
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  • [Title] Preoperative investigations for metastatic staging of colon and rectal cancer across multiple centres--what is current practice?
  • CT abdomen/pelvis was performed in 222 (86%) of cases, ranging from 69% to 98% per centre.
  • In 17 cases (18%) CT chest examinations revealed abnormalities suspicious for metastatic disease, leading to a change in management in six (35%) of these cases.

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  • (PMID = 18624816.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen
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12. Fiore D, Baggio V, Ruol A, Bocus P, Casara D, Corti L, Muzzio PC: Multimodal imaging of esophagus and cardia cancer before and after treatment. Radiol Med; 2006 Sep;111(6):804-17
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  • [Title] Multimodal imaging of esophagus and cardia cancer before and after treatment.
  • PURPOSE: Prognosis and treatment of esophagus and cardia cancer (ECC) depend on the precision with which the disease is staged according to the American Joint Committee of Cancer (AJCC) criteria.
  • MATERIALS AND METHODS: Fifty-six patients with ECC diagnosed by X-ray of the upper digestive tract, endoscopy and biopsy were staged using EUS, chest and abdomen CT scan, and CT-PET.
  • In the 52 patients who had surgery, follow-up included digestive tract X-ray, endoscopy and CT of the chest and abdomen every 6-8 months for the first 3 years.
  • Only CT-PET revealed metastatic subdiaphragmatic lymph nodes (diameter <15 mm) in three cases.
  • Presurgical restaging of the 18 patients (stage III) who had chemotherapy was based on endoscopy, EUS, CT of the chest and abdomen and CT-PET (only in suspected cases) and was compatible with surgery.
  • CONCLUSIONS: X-ray of the upper digestive tract and chest and abdomen CT scan are useful in preliminary evaluation of ECC.
  • CT-PET is extremely useful in identifying small mediastinal metastatic lymph nodes (N1) or extrathoracic lymph nodes (M1) and hepatic metastases (</=1 cm), which may escape multislice CT.

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  • (PMID = 16896560.001).
  • [ISSN] 0033-8362
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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13. Glasgow CG, Taveira-DaSilva A, Pacheco-Rodriguez G, Steagall WK, Tsukada K, Cai X, El-Chemaly S, Moss J: Involvement of lymphatics in lymphangioleiomyomatosis. Lymphat Res Biol; 2009 Dec;7(4):221-8
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  • Lymphangioleiomyomatosis (LAM), a rare multisystem disease, occurs primarily in women, with cystic destruction of the lungs, abdominal tumors, and involvement of the axial lymphatics in the thorax and abdomen.
  • Consistent with their metastatic behavior, LAM cells were isolated from blood, urine, and chylous effusions.
  • Surface proteins on LAM cells include those found on metastatic cells and those involved in cell migration.
  • LAM cell clusters have been isolated from chylous pleural effusions, and it is hypothesized that these clusters may be responsible for metastatic spread of LAM cells via lymphatic vessels.

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  • (PMID = 20143921.001).
  • [ISSN] 1557-8585
  • [Journal-full-title] Lymphatic research and biology
  • [ISO-abbreviation] Lymphat Res Biol
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Vascular Endothelial Growth Factor D
  • [Other-IDs] NLM/ PMC2883505
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14. Dietrich CF, Braden B, Hocke M, Ott M, Ignee A: Improved characterisation of solitary solid pancreatic tumours using contrast enhanced transabdominal ultrasound. J Cancer Res Clin Oncol; 2008 Jun;134(6):635-43
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  • PATIENTS AND METHODS: A total of 112 solitary undetermined pancreatic masses (70 ductal adenocarcinoma and 42 neoplastic nodules of other origin) were prospectively examined in patients without metastatic disease using transabdominal ultrasound.
  • [MeSH-major] Abdomen / diagnostic imaging. Pancreatic Neoplasms / diagnostic imaging

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  • [ErratumIn] J Cancer Res Clin Oncol. 2008 Jun;134(6):723
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  • (PMID = 17952469.001).
  • [ISSN] 0171-5216
  • [Journal-full-title] Journal of cancer research and clinical oncology
  • [ISO-abbreviation] J. Cancer Res. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media
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15. Park JM, Kim DS, Oh SH, Kwon YS, Lee KH: A case of esophageal adenocarcinoma metastasized to the scalp. Ann Dermatol; 2009 May;21(2):164-7
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  • Lung, breast, and colorectal cancers are common primary tumors that metastasize to the skin; cutaneous metastasis usually occurs on the chest wall and abdomen as asymptomatic nodular patterns.
  • Esophageal cancer is not nearly as common as breast, lung, and colorectal cancers, and esophageal cancer rarely metastasizes to the skin.
  • Cutaneous metastasis of esophageal cancer is rare and metastasis to the scalp is extremely rare.
  • Only a few cases of cutaneous metastases of esophageal cancer have been reported in Korea.
  • Herein, we describe a case of metastatic skin cancer that originated from esophageal adenocarcinoma.

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  • (PMID = 20523777.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2861207
  • [Keywords] NOTNLM ; Adenocarcinoma / Esophagus / Metastasis / Scalp
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16. Giannakis D, Tsili AC, Zioga A, Tsampoulas K, Sofikitis N: Early-stage sarcomatoid renal cell carcinoma: multidetector CT findings. Urol Int; 2009;82(3):367-9
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  • A 64-year-old woman was referred for multidetector CT examination of the abdomen due to an incidental right renal mass, found on routine sonographic examination.
  • A lower pole renal mass was detected on CT, with no signs of invasiveness or metastatic disease.
  • [MeSH-minor] Biopsy. Early Detection of Cancer. Female. Humans. Incidental Findings. Middle Aged. Neoplasm Staging. Nephrectomy. Treatment Outcome

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19440031.001).
  • [ISSN] 1423-0399
  • [Journal-full-title] Urologia internationalis
  • [ISO-abbreviation] Urol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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17. Stroszczynski C, Jost D, Reichardt P, Chmelik P, Gaffke G, Kretzschmar A, Schneider U, Felix R, Hohenberger P: Follow-up of gastro-intestinal stromal tumours (GIST) during treatment with imatinib mesylate by abdominal MRI. Eur Radiol; 2005 Dec;15(12):2448-56
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  • MRI was performed in 45 patients (25 responders, 20 non-responders) with metastatic or locally advanced, unresectable GIST.
  • [MeSH-major] Abdomen / pathology. Gastrointestinal Stromal Tumors / drug therapy. Gastrointestinal Stromal Tumors / pathology. Magnetic Resonance Imaging / methods. Piperazines / therapeutic use. Pyrimidines / therapeutic use


18. Petrović D, Muzikravić L, Jovanović D: [Metastases of unknown origin--principles of diagnosis and treatment]. Med Pregl; 2007 Jan-Feb;60(1-2):29-36
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  • DEFINITION: Cancer of unknown primary (CUP) origin refers to patients who present with histologicaly confirmed metastatic cancer in whom a detailed medical history, complete physical examination, including pelvic and rectal examination, full blood count and biochemistry, urinalysis and stool occult blood testing, hisinpathological review oJ biopsy speimens with the use of immunohistochemistry, chest radiography, computed tomography of the abdomen and pelvis, and in certain cases mammography, fail to identify the primary site.
  • EPIDEMIOLOGY OF CUP: The cancer of unknown primary accounts for 3%-5% of all human cancers.
  • DIAGNOSIS OF CUP: The standard diagnostic procedure for the majority of patients includes histopathologic review of biopsy specimens with the use of immunoltistochemistry, chest radiography, computed tomography of the abdomen and pelvis, and in certain cases mamography, fail to identify the abdomen and pelvis.
  • CONCLUSION: Metastatic tumors of unknown origin have a unique clinical presentation due to a specific biology.

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  • (PMID = 17853708.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Serbia and Montenegro
  • [Number-of-references] 41
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19. Pouessel D, Thezenas S, Culine S, Becht C, Senesse P, Ychou M: Hepatic metastases from carcinomas of unknown primary site. Gastroenterol Clin Biol; 2005 Dec;29(12):1224-32
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  • METHODS: One hundred and eighteen patients were treated at the Cancer Center of Montpellier from 1993 to 2002 for CUP initially metastatic to the liver.
  • Hepatic metastases revealed the cancer in 66 patients and were isolated in 32 patients.
  • Other metastatic sites involved lymph nodes, lung and bone.
  • Pretreatment computed tomography scans of the chest, abdomen and pelvis evaluation were available for more than 80% of patients.

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  • (PMID = 16518276.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] EC 1.1.1.27 / L-Lactate Dehydrogenase
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20. Chen JH, Chang PY, Ho CL, Chen YC, Kao WY: Retroperitoneal metastatic adenocarcinoma complicated with necrotizing fasciitis of the thigh in a patient with advanced rectal colon cancer. Case Rep Oncol; 2010;3(2):304-9
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  • [Title] Retroperitoneal metastatic adenocarcinoma complicated with necrotizing fasciitis of the thigh in a patient with advanced rectal colon cancer.
  • BACKGROUND: Necrotizing fasciitis of the thigh due to colon cancer has not been previously reported, especially during radiotherapy.
  • CASE PRESENTATION: A 73-year-old woman admitted to our hospital was diagnosed with sigmoid colon cancer that had spread to the left psoas muscle; radiotherapy was performed.
  • Computed tomography of the abdomen revealed fluid and gas tracking from the retroperitoneum into the intramuscular plane of the grossly enlarged right thigh.
  • CONCLUSION: Necrotizing fasciitis of the thigh due to the spread of rectal colon cancer is unusual, but this fatal complication should be considered during radiotherapy in patients with unresectable colorectal cancer.

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  • (PMID = 21347198.001).
  • [ISSN] 1662-6575
  • [Journal-full-title] Case reports in oncology
  • [ISO-abbreviation] Case Rep Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Other-IDs] NLM/ PMC3042024
  • [Keywords] NOTNLM ; Colon cancer / Necrotizing fasciitis / Retroperitoneal
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21. Alaggio R, Cecchetto G, Bisogno G, Gambini C, Calabrò ML, Inserra A, Boldrini R, De Salvo GL, G d'Amore ES, Dall'igna P: Inflammatory myofibroblastic tumors in childhood: a report from the Italian Cooperative Group studies. Cancer; 2010 Jan 1;116(1):216-26
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  • RESULTS: Patients ages 8-216 months (median age, 60 months) presented with tumors of the lung-bronchus (8 patients), abdomen (17 patients), and thoracic wall (1 patient).
  • The results indicated that the treatment of choice is a complete, nonmutilating excision; chemotherapy may be given to patients who have microscopic or macroscopic residual disease, although the results are controversial; cytologic atypia and positive ALK status are more frequent in aggressive tumors, whereas metastatic tumors are negative for ALK; and HHV8 is not involved in the pathogenesis of IMT.

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  • [Copyright] Copyright 2010 American Cancer Society.
  • (PMID = 19852031.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / anaplastic lymphoma kinase
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22. Gold JS, Jaques DP, Busam KJ, Brady MS, Coit DG: Yield and predictors of radiologic studies for identifying distant metastases in melanoma patients with a positive sentinel lymph node biopsy. Ann Surg Oncol; 2007 Jul;14(7):2133-40
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  • At least one study (computed tomography or magnetic resonance imaging of the brain; chest x-ray; computed tomography of the thorax, abdomen, or pelvis; positron-emission tomography scan; or bone scan) was obtained around the time of SLNB in 178 patients (98%).
  • Among patients tested after SLNB, four were found to have metastatic disease (positive rate 3.7%).

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  • (PMID = 17453294.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Qi XP, Lin GB, Zhu YL, Wang JQ, Dai XW, Ma JM, Yan L: [Pseudoangiosarcomatous squamous cell carcinoma of the penis: a case report with clinicopathological and human papilloma virus analyses]. Zhonghua Nan Ke Xue; 2009 Feb;15(2):134-9
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  • CT scanning showed no enlarged lymph nodes in the abdomen and pelvis, and X-ray examination revealed no abnormality in the chest.
  • Under the light microsope, the tumor was mainly composed of vessel-like lacunar reticularis spindle cells and a few local squamous cancer cells.
  • HPV DNA (HPVpan, HPV6B/11, HPV16/18, HPV31/33) was not detected by in situ hybridization in the primary and metastatic tumors.


24. Schmidt GP, Baur-Melnyk A, Haug A, Utzschneider S, Becker CR, Tiling R, Reiser MF, Hermann KA: Whole-body MRI at 1.5 T and 3 T compared with FDG-PET-CT for the detection of tumour recurrence in patients with colorectal cancer. Eur Radiol; 2009 Jun;19(6):1366-78
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  • [Title] Whole-body MRI at 1.5 T and 3 T compared with FDG-PET-CT for the detection of tumour recurrence in patients with colorectal cancer.
  • The purpose of this study was to assess the diagnostic accuracy of whole-body MRI (WB-MRI) at 1.5 T or 3 T compared with FDG-PET-CT in the follow-up of patients suffering from colorectal cancer.
  • In a retrospective study, 24 patients with a history of colorectal cancer and suspected tumour recurrence underwent FDG-PET-CT and WB-MRI with the use of parallel imaging (PAT) for follow-up.
  • High resolution coronal T1w-TSE and STIR sequences at four body levels, HASTE imaging of the lungs, contrast-enhanced T1w- and T2w-TSE sequences of the liver, brain, abdomen and pelvis were performed, using WB-MRI at either 1.5 T (n = 14) or 3 T (n = 10).
  • Presence of local recurrent tumour, lymph node involvement and distant metastatic disease was confirmed using radiological follow-up within at least 5 months as a standard of reference.
  • Initial results suggest that differences in accuracy for local and distant metastases detection using FDG-PET-CT and WB-MRI for integrated screening of tumour recurrence in colorectal cancer depend on the location of the malignant focus.


25. Schmidt GP, Baur-Melnyk A, Haug A, Heinemann V, Bauerfeind I, Reiser MF, Schoenberg SO: Comprehensive imaging of tumor recurrence in breast cancer patients using whole-body MRI at 1.5 and 3 T compared to FDG-PET-CT. Eur J Radiol; 2008 Jan;65(1):47-58
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  • [Title] Comprehensive imaging of tumor recurrence in breast cancer patients using whole-body MRI at 1.5 and 3 T compared to FDG-PET-CT.
  • PURPOSE: To compare the diagnostic accuracy for the detection of tumor recurrence in breast cancer patients using whole-body-MRI (WB-MRI) at 1.5 or 3T compared to FDG-PET-CT.
  • MATERIALS AND METHODS: Thirty-three female patients with breast cancer and suspicion of recurrence underwent FDG-PET-CT and WB-MRI.
  • Coronal T1w-TSE- and STIR-sequences, HASTE-imaging of the lungs, contrast-enhanced T1w- and T2w-TSE-sequences of the liver, brain and abdomen were performed, using a WB-MRI-scanner at 1.5 (n=23) or 3T (n=10).
  • Presence of local recurrence, lymph node involvement and distant metastatic disease was assessed using clinical and radiological follow-up as a standard of reference.
  • CONCLUSION: WB-MRI and PET-CT are useful for the detection of tumor recurrence in the follow-up of breast cancer.
  • WB-MRI is highly sensitive to distant metastatic disease.

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  • (PMID = 18082989.001).
  • [ISSN] 0720-048X
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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26. Musser JE, Przybycin CG, Russo P: Regression of metastatic seminoma in a patient referred for carcinoma of unknown primary origin. Nat Rev Urol; 2010 Aug;7(8):466-70
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  • [Title] Regression of metastatic seminoma in a patient referred for carcinoma of unknown primary origin.
  • Repeat CT showed complete resolution of the metastatic para-aortic mass.
  • INVESTIGATIONS: CT of the chest, abdomen and pelvis, measurement of serum tumor markers, upper gastrointestinal endoscopy, colonoscopy, PET-CT and percutaneous needle biopsy of the para-aortic mass at the first presentation; physical examination, review of biopsy specimen with immunohistochemical staining for tumor markers, testicular ultrasonography and repeat CT of the chest, abdomen and pelvis at the second presentation.
  • DIAGNOSIS: Metastatic seminoma with spontaneous regression of the metastatic lesion.

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  • (PMID = 20606623.001).
  • [ISSN] 1759-4820
  • [Journal-full-title] Nature reviews. Urology
  • [ISO-abbreviation] Nat Rev Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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27. Kyo S, Hashimoto M, Maida Y, Mizumoto Y, Nakamura M, Takakura M, Inoue M: Analysis of outcome of Stage I-III endometrial cancer treated with systematic operation omitting paraaortic lymphadenectomy. Eur J Gynaecol Oncol; 2007;28(3):170-3
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  • [Title] Analysis of outcome of Stage I-III endometrial cancer treated with systematic operation omitting paraaortic lymphadenectomy.
  • PURPOSE: The aim of this study was to assess the outcomes of endometrial cancer patients treated with systematic surgery omitting paraarotic lymphadenectomy.
  • PATIENTS AND METHODS: We retrospectively analyzed a consecutive series of 84 endometrioid-type endometrial cancer patients at FIGO Stage I, II or III without grossly metastatic paraaortic lymphadenodes, who underwent surgery at our institute.
  • Out of the eight recurrent patients, five patients had a recurrent tumor at extra-pelvic sites (chest or abdomen), two patients had a recurrent tumor only in a paraaortic lymph node, and one patient had a recurrent tumor only in the vagina.
  • CONCLUSIONS: These findings indicate that omission of paraarotic lymphadenectomy may be acceptable for endometrial cancer patients without gross metastasis at this site.

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  • (PMID = 17624080.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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28. Ismaili N, Naciri S, Afqir S, Mellas N, Bekkouch I, Elmajjaoui S, Masbah O, Othmani N, Flechon A, Droz JP, Errihani H: A rare case of advanced testicular seminoma in a 78-year-old man managed successfully with carboplatin based chemotherapy: a case report. Cases J; 2008;1(1):357
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  • We present a rare case of metastatic seminoma of the testis associated with liver and renal insufficiencies in a 78-years-old man managed successfully with carboplatin based chemotherapy.
  • CASE PRESENTATION: A 78 years old man admitted with signs and symptoms suggestive of a testicular cancer with alteration of health.
  • Computed tomography of the pelvis and abdomen showed a large retroperitoneal tumour.

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  • (PMID = 19040740.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2613406
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29. Chiu WK, Lin YC, Wang LT, Chen JH, Yu JC, Hsieh CB: Jejunojejunal intussusception secondary to metastasis from adenocarcinoma of the lung--a case report. Acta Chir Belg; 2009 Jul-Aug;109(4):519-22
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  • Small intestine metastasis from primary lung cancer is uncommon and jejunojejunal intussusception secondary to metastatic lung cancer is extremely rare.
  • Computed tomography (CT) of the abdomen demonstrated a "target mass" lesion in the right lower abdomen, representing a small intestinal intussusception.
  • Histological examination of the specimen revealed metastatic adenocarcinoma of lung origin.


30. Galeotti F, Facci E, Bianchini E: Desmoid tumour involving the abdominal rectus muscle: report of a case. Hernia; 2006 Jun;10(3):278-81
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  • The desmoid tumour (DT) is a quite rare soft tissues neoplasm that lacks metastatic potential.
  • The presented case report refers to a young female in her childbearing age, who underwent the radical excision of a large DT infiltrating the left rectus muscle of the abdomen.

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  • (PMID = 16554982.001).
  • [ISSN] 1265-4906
  • [Journal-full-title] Hernia : the journal of hernias and abdominal wall surgery
  • [ISO-abbreviation] Hernia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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31. Yancovitz M, Finelt N, Warycha MA, Christos PJ, Mazumdar M, Shapiro RL, Pavlick AC, Osman I, Polsky D, Berman RS: Role of radiologic imaging at the time of initial diagnosis of stage T1b-T3b melanoma. Cancer; 2007 Sep 1;110(5):1107-14
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  • METHODS: The melanoma database was searched for patients with T1b-T3b primary lesions, clinically N0, and asymptomatic for metastatic disease.
  • RESULTS: In all, 344 preoperative imaging studies (chest x-ray [CXR], computed tomography [CT], positron emission tomography [PET]/CT) were performed on 158 patients, resulting in 49 findings suspicious for metastatic melanoma and 134 findings suggestive of nonmelanoma pathology.
  • Only 1 of 344 (0.3%) studies, a PET/CT, correlated with confirmed metastatic melanoma.
  • The false-positive rates were CXR 5 of 7 (71.4%), chest CT 21 of 24 (87.5%), abdomen/pelvis CT 10 of 11 (90.9%), head CT 2 of 2 (100.0%), PET/CT 3 of 5 (60.0%).

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  • (PMID = 17620286.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Grant] United States / NIAMS NIH HHS / AR / T32 AR07190-31
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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32. Wolfsen HC, Hemminger LL: Salvage photodynamic therapy for persistent esophageal cancer after chemoradiation therapy. Photodiagnosis Photodyn Ther; 2006 Mar;3(1):11-4
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  • [Title] Salvage photodynamic therapy for persistent esophageal cancer after chemoradiation therapy.
  • BACKGROUND: Locally advanced esophageal cancer may not be completely eradicated after chemoradiation therapy (CRT) and further treatment options are limited.
  • After upper endoscopy with biopsies documented neoplasm after CRT, patients were evaluated with contrast-enhanced computed tomography of the chest and abdomen as well as endoscopic ultrasound to confirm persistence/recurrence of only mucosal disease.
  • The other five patients treated for Barrett's carcinoma have remained disease free although one had died 33 months from metastatic colon cancer.
  • CONCLUSION: In selected patients, PDT may be useful in the treatment of persistent/recurrent mucosal esophageal cancer after incomplete response to CRT.

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  • (PMID = 25049021.001).
  • [ISSN] 1572-1000
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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33. Da Ines D, Petitcolin V, Joubert-Zakeyh J, Demeocq F, Garcier JM: Epithelioid hemangioendothelioma of the liver with metastatic coeliac lymph nodes in an 11-year-old boy. Pediatr Radiol; 2010 Jul;40(7):1293-6
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  • [Title] Epithelioid hemangioendothelioma of the liver with metastatic coeliac lymph nodes in an 11-year-old boy.
  • [MeSH-minor] Abdomen / diagnostic imaging. Child. Humans. Lymphatic Metastasis. Male. Radiography, Abdominal. Subtraction Technique

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34. Schmidt GP, Schoenberg SO, Schmid R, Stahl R, Tiling R, Becker CR, Reiser MF, Baur-Melnyk A: Screening for bone metastases: whole-body MRI using a 32-channel system versus dual-modality PET-CT. Eur Radiol; 2007 Apr;17(4):939-49
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  • PET-CT was conducted using a low-dose CT for attenuation correction, a PET-emission scan and diagnostic contrast-enhanced CT scan covering the thorax, abdomen and pelvis.
  • In conclusion, WB-MRI and FDG-PET-CT are robust imaging modalities for a systemic screening for metastatic bone disease.

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  • (PMID = 16951929.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Clinical Trial; Comparative Study; Journal Article
  • [Publication-country] Germany
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35. Tjalma WA, Colpaert CG: Primary vaginal adenocarcinoma of intestinal type arising from a tubulovillous adenoma. Int J Gynecol Cancer; 2006 May-Jun;16(3):1461-5
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  • The histologic interpretation pointed in the direction of a metastatic gastrointestinal tumor; yet, clinical examination, rectoscopy, colonoscopy, magnetic resonance imaging (MRI) of the abdomen, and positron emission tomography (PET) scanning excluded this possibility.
  • It is important to be aware of this tumor type and to distinguish them from metastatic colorectal adenocarcinoma in order to plan appropriate treatment.

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  • (PMID = 16803550.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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36. Dainty LA, Krivak TC, Webb JC, Zahn CM, Elkas JC, Chernofsky MR, Rose GS, Maxwell GL: Diffuse laminar endocervical glandular hyperplasia: a case report. Int J Gynecol Cancer; 2009 Aug;19(6):1091-3
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  • Computed tomographic scans of the abdomen and the pelvis failed to reveal any metastatic foci.


37. Heinzerling JH, Huerta S: Bowel perforation from bevacizumab for the treatment of metastatic colon cancer: incidence, etiology, and management. Curr Surg; 2006 Sep-Oct;63(5):334-7
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  • [Title] Bowel perforation from bevacizumab for the treatment of metastatic colon cancer: incidence, etiology, and management.
  • Avastin (Bevacizumab) is a recently developed monoclonal antibody against vascular endothelial growth factor (VEGF) receptor that increases survival in patients with metastatic colorectal cancer.
  • [MeSH-major] Abdomen, Acute / chemically induced. Adenocarcinoma / drug therapy. Angiogenesis Inhibitors / adverse effects. Antibodies, Monoclonal / adverse effects. Intestinal Perforation / chemically induced. Neoplasm Recurrence, Local / drug therapy. Rectal Neoplasms / drug therapy

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  • (PMID = 16971205.001).
  • [ISSN] 0149-7944
  • [Journal-full-title] Current surgery
  • [ISO-abbreviation] Curr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 2S9ZZM9Q9V / Bevacizumab
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38. Huh WK, Straughn JM Jr, Mariani A, Podratz KC, Havrilesky LJ, Alvarez-Secord A, Gold MA, McMeekin DS, Modesitt S, Cooper AL, Powell MA, Mutch DG, Nag S, Alvarez RD, Cohn DE: Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience. Int J Gynecol Cancer; 2007 Jul-Aug;17(4):886-9
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  • [Title] Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience.
  • Metastatic disease in the chest and abdomen was excluded by radiologic studies.
  • Sixty-nine women with surgical stage I endometrial cancer with isolated vaginal recurrences were identified.
  • The majority of isolated vaginal recurrences in women with surgical stage I endometrial cancer can be successfully salvaged with radiation therapy, further questioning the role of adjuvant therapy for patients with uterine-confined endometrial cancer at the time of initial diagnosis.

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  • (PMID = 17309665.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study
  • [Publication-country] United States
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39. Matsuoka T, Kaneda Y, Fujita N, Ueda K, Sakano H, Tanaka T, Nojima S, Hamano K: [Simultaneous resection of pulmomary metastasis of colon cancer and primary lung cancer]. Kyobu Geka; 2005 Mar;58(3):191-5
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  • [Title] [Simultaneous resection of pulmomary metastasis of colon cancer and primary lung cancer].
  • On palpation, the unmobilized mass, measuring 5 cm, was located in the left lower abdomen.
  • At first, we performed sigmoidectomy (D 3) for the colon cancer.
  • Histopathologically, the one is a primary lung cancer, the other is a metastatic lung cancer.
  • With an increase in colorectal and lung cancer, similar cases as ours seem to increase in number.
  • When we treat multiple lung nodules with malignancy of other organs, we should consider 3 types of cases, 1) only primary, 2) primary and metastatic, 3) only metastatic.

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  • (PMID = 15776735.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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40. Sun H, Sloan A, Mangner TJ, Vaishampayan U, Muzik O, Collins JM, Douglas K, Shields AF: Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer. Eur J Nucl Med Mol Imaging; 2005 Jan;32(1):15-22
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  • [Title] Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer.
  • Unlike with other tracers of proliferation, low uptake of [18F]FMAU was seen in the normal bone marrow (SUV(mean) 0.7), allowing visualization of metastatic prostate cancer (SUV 3.07).
  • In the abdomen, increased physiological uptake was seen in the liver (SUV 10.07-20.88) and kidneys (SUV 7.18-15.66) due to metabolism and/or excretion, but the urinary bladder was barely visible (SUV(mean) 2.03).
  • In the upper abdomen, visualization is limited by the physiological uptake by the liver and kidneys.

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  • (PMID = 15586282.001).
  • [ISSN] 1619-7070
  • [Journal-full-title] European journal of nuclear medicine and molecular imaging
  • [ISO-abbreviation] Eur. J. Nucl. Med. Mol. Imaging
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA 82645; United States / NCI NIH HHS / CA / CA 83131
  • [Publication-type] Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / DNA, Neoplasm; 0 / Radiopharmaceuticals; 3083-77-0 / Arabinofuranosyluracil; IN51MVP5F1 / Clevudine
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41. Ong PH, Manikandan R, Philip J, Hope K, Williamson M: Primitive neuroectodermal tumour of the kidney with vena caval and atrial tumour thrombus: a case report. J Med Case Rep; 2008;2:265
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  • Computed tomography of the thorax and abdomen revealed an extension of the large renal mass into the right renal vein, inferior vena cava and up to the right atrium.
  • A small paracaval lymph node was noted and three small metastatic nodules were identified within the lung parenchyma.

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  • [Cites] Urology. 2008 Feb;71(2):292-6 [18308106.001]
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  • (PMID = 18694498.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2527024
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42. Mizoshita T, Kataoka H, Kubota E, Okamoto Y, Shimura T, Mori Y, Wada T, Ogasawara N, Sasaki M, Kamiya T, Joh T: Gastric phenotype signet-ring cell carcinoma of the stomach with multiple bone metastases effectively treated with sequential methotrexate and 5-fluorouracil. Int J Clin Oncol; 2008 Aug;13(4):373-6
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  • Computed tomography (CT) scan of the abdomen and pelvis and radioisotope (RI) examination led to a strong suspicion of systemic bone metastatic tumors, although the origin was not known.
  • Biopsies from bone metastatic lesions in the left ilium were performed under CT scan, and signet-ring cell carcinoma cells were detected pathologically.
  • Both the stomach and the bone metastatic lesions exhibited a gastric phenotype (G type) phenotypically.
  • From these findings, we diagnosed the patient as having advanced (inoperable) stomach cancer with multiple bone metastases; she also exhibited disseminated intravascular coagulation (DIC).
  • In conclusion, sequential MTX/5-FU therapy was effective for a patient with G-type signet-ring cell carcinoma of the stomach with bone metastases, suggesting that the phenotypic classification may be one of the useful markers for prediction of the effectiveness of chemotherapy in patients with inoperable advanced stomach cancer.

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  • (PMID = 18704642.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] U3P01618RT / Fluorouracil; YL5FZ2Y5U1 / Methotrexate
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43. Ismaili N, Ghanem S, Mellas N, Afqir S, Taleb M, Amrani M, Gamra L, Errihani H: Small cell carcinoma of the urinary bladder: a case report and review of the literature. J Cancer Res Ther; 2009 Apr-Jun;5(2):133-6
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  • In this paper, we present a case of metastatic SCCB managed by chemotherapy and we would provide a brief review of the epidemiology, clinical features, diagnosis, pathologic features, staging, treatment, and prognosis of SCCB.
  • A 52-year-old man was admitted with signs and symptoms suggestive of a bladder cancer.
  • Computed tomography of the pelvis and abdomen showed a large tumor at the right bladder wall, measuring 10 cm in diameter, and a multinodular liver disease.

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  • (PMID = 19542673.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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44. Jacene HA, Stearns V, Wahl RL: Lymphadenopathy resulting from acute hepatitis C infection mimicking metastatic breast carcinoma on FDG PET/CT. Clin Nucl Med; 2006 Jul;31(7):379-81
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  • [Title] Lymphadenopathy resulting from acute hepatitis C infection mimicking metastatic breast carcinoma on FDG PET/CT.
  • A 42-year-old African-American female with a history of metastatic breast carcinoma was found to have hypermetabolic porta hepatic, peripancreatic, and paraaortic lymphadenopathy and hypermetabolism in the spleen on a surveillance FDG positron emission tomography/computed tomography (PET/CT) scan.
  • Her breast cancer therapy regimen was continued unaltered.
  • FDG PET/CT scan was repeated 2 months later as a result of concern that the hypermetabolic lymph nodes represented metastatic disease; however, the scan revealed complete resolution of the previously abnormal findings.
  • The resolution of the lymphadenopathy and the patient's clinical course led to the conclusion that the most likely explanation for the FDG PET/CT findings was inflammation secondary to acute hepatitis C infection and not metastatic breast carcinoma.
  • [MeSH-minor] Abdomen. Acute Disease. Adult. Antineoplastic Agents, Hormonal / therapeutic use. Aromatase Inhibitors / therapeutic use. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Mastectomy. Radiotherapy, Adjuvant. Spinal Neoplasms / drug therapy. Spinal Neoplasms / radiotherapy. Spinal Neoplasms / secondary. Spleen / radionuclide imaging. Tamoxifen / therapeutic use. Thoracic Vertebrae

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  • (PMID = 16785802.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Hormonal; 0 / Aromatase Inhibitors; 0 / Radiopharmaceuticals; 094ZI81Y45 / Tamoxifen; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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45. Kumar R, Alavi A: Clinical applications of fluorodeoxyglucose--positron emission tomography in the management of malignant melanoma. Curr Opin Oncol; 2005 Mar;17(2):154-9
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  • PURPOSE OF REVIEW: Malignant melanoma is the seventh most common newly diagnosed cancer among Americans.
  • PET has been shown to have a strong role in detection of metastatic disease.
  • It is more sensitive than computed tomography (CT) for detection of metastatic lesions in skin, lymph nodes, and abdomen.
  • SUMMARY: FDG-PET is a metabolic, noninvasive imaging modality for detecting distant metastatic and recurrent melanoma.

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  • (PMID = 15725921.001).
  • [ISSN] 1040-8746
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 37
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46. Udomsawaengsup S, Brethauer S, Kroh M, Chand B: Percutaneous transesophageal gastrostomy (PTEG): a safe and effective technique for gastrointestinal decompression in malignant obstruction and massive ascites. Surg Endosc; 2008 Oct;22(10):2314-8
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  • Percutaneous transesophageal gastrostomy (PTEG) is a nonsurgical technique that creates an esophagostomy and allows enteral access in patients with a hostile abdomen, altered gastric anatomy, massive ascites, and carcinomatosis.
  • METHODS: Patients were terminally ill from advanced cancer requiring gastrointestinal decompression or had hostile abdomens needing long-term feeding access.
  • Except for two patients, all of the patients had advanced metastatic cancer.

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  • (PMID = 18622539.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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47. Roybal JJ, Feliberti EC, Rouse L, Wagman LD: Pump removal in infected patients with hepatic chemotherapy pumps: when is it necessary? Am Surg; 2006 Oct;72(10):880-4
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  • Hepatic chemotherapy pumps have been shown to be an effective and well-tolerated treatment for metastatic colorectal cancer confined to the liver.
  • The rate of infection was 22.7% (n = 17), including eight infections localized to the abdomen (entailing five wound infections, three hepatic abscesses, and two pump pocket infections).

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  • (PMID = 17058726.001).
  • [ISSN] 0003-1348
  • [Journal-full-title] The American surgeon
  • [ISO-abbreviation] Am Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 039LU44I5M / Floxuridine
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48. Jalali R, Munshi A, Arora B: Curability of cancer by radiotherapy and chemotherapy, including in neuraxial neoplasms. Neurol India; 2009 Jan-Feb;57(1):13-9
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  • [Title] Curability of cancer by radiotherapy and chemotherapy, including in neuraxial neoplasms.
  • In the October of 1996, Lance Armstrong, celebrated cyclist and one of the greatest athletes the world has ever seen, at the age of 24, was diagnosed with metastatic testicular cancer with disease having already spread to his abdomen, lungs and brain.
  • Lance underwent four cycles of chemotherapy, actually the pretty standard one, pioneered at the Indiana University and not only did he get completely cured of his cancer, he remains extremely well till date, 12 years later.
  • After his retirement, he has been so inspired that he has completely devoted himself to educate people about the common myths about cancer, and promised to raise awareness and generate money for furthering research into surgery, radiation therapy and chemotherapy for cancer through his foundation.
  • In his successful journey of overcoming cancer, he captures the essence of its treatment so well by declaring "Pain is temporary, it may last a minute, or an hour, or a day, or a year, but eventually, it will subside and something else will take its place.

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  • (PMID = 19305070.001).
  • [ISSN] 0028-3886
  • [Journal-full-title] Neurology India
  • [ISO-abbreviation] Neurol India
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 37
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49. Dugalic V, Popovic N, Gojnic M, Arsenijevic Lj, Filimonovic D, Jeremic V: Torsion of carcinomatous ovarian cyst and polycystic omental diseases--case report. Eur J Gynaecol Oncol; 2006;27(6):629-31
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  • A middle-aged patient, without any positive personal or familial history was urgently hospitalized and, after primary diagnostic procedures, treated by surgery for torsion and acute abdomen.
  • Primary ovarian cancer and secondary polycystic metastatic echoes of the omentum were established by histopathology.
  • [MeSH-major] Abdomen, Acute / surgery. Cystadenocarcinoma / pathology. Omentum / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / pathology

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  • (PMID = 17290601.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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50. Cadière GB, Himpens J, Torres R, Dapri G, Bosschaerts T, Karler C, Haller A: Multimedia article. Entirely thoracoscopic pneumonectomy using the prone position: a new technique. Surg Endosc; 2005 Sep;19(9):1282-3
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  • METHODS: A 49-year-old man was admitted to our hospital for a bifocal cancer of the left lower lung lobe (LLL) and the cervical esophagus.
  • Biopsy showed spinocellular epithelioma, but CT scan of the abdomen and bone scintigraphy did not show metastatic disease.

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  • (PMID = 16249969.001).
  • [ISSN] 1432-2218
  • [Journal-full-title] Surgical endoscopy
  • [ISO-abbreviation] Surg Endosc
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] Germany
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51. Al-Talib A, Gilbert L, Arseneau J: Endometrioid adenocarcinoma 13 years after total abdominal hysterectomy and bilateral salpingo-oophorectomy. Saudi Med J; 2008 Jul;29(7):1044-7
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  • As endometriosis is an ectopic endometrium, hyperestrogenism may cause hyperplasia or transformation into cancer.
  • Computed tomography of chest, pelvis, and abdomen, demonstrated right-sided pleural effusion and soft tissue mass in the pelvis.
  • Pleural effusion was tapped and biopsy from the peritoneal mass showed metastatic adenocarcinoma; immunohistochemistry findings favored endometrioid adenocarcinoma.

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  • (PMID = 18626539.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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52. Metser U, You J, McSweeney S, Freeman M, Hendler A: Assessment of tumor recurrence in patients with colorectal cancer and elevated carcinoembryonic antigen level: FDG PET/CT versus contrast-enhanced 64-MDCT of the chest and abdomen. AJR Am J Roentgenol; 2010 Mar;194(3):766-71
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  • [Title] Assessment of tumor recurrence in patients with colorectal cancer and elevated carcinoembryonic antigen level: FDG PET/CT versus contrast-enhanced 64-MDCT of the chest and abdomen.
  • OBJECTIVE: The purpose of this study was to compare FDG PET/CT and contrast-enhanced 64-MDCT of the chest, abdomen, and pelvis in the detection of tumor recurrence in patients with colorectal cancer and an elevated level of carcinoembryonic antigen (CEA).
  • RESULTS: Recurrent or metastatic disease was found in 36 of 55 events (65.5%) of elevated CEA.
  • Fifty-four of 61 tumor sites suspected as tumor recurrence with any imaging technique were found to be local recurrence or metastatic colorectal cancer at final analysis.
  • Tumors correctly identified with PET/CT and missed with MDCT were local recurrence in the presacral space (n = 5), metastatic subcentimeter lymph nodes (n = 4), peritoneal deposits (n = 3), and recurrences at the periphery of radiofrequency ablated metastatic lesions of the liver (n = 2) and in the abdominal wall (n = 1), liver (n = 1), and uterine cervix (n = 1).
  • CONCLUSION: FDG PET/CT has higher sensitivity than MDCT in the identification of sites of recurrent and metastatic disease in patients with colorectal cancer and an elevated CEA level.

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  • (PMID = 20173157.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Contrast Media; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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53. Wang JY, Chai CY, Su YC, Soo KM, Huang YS, Huang TJ, Hsieh JS: Cutaneous metastasis from gastric adenocarcinoma: a case report. Kaohsiung J Med Sci; 2005 Jul;21(7):329-32
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  • We report a case of a 57-year-old male patient with gastric cancer who developed generalized erythematous nodules on the chest, abdomen, back, neck, and four extremities 2 months postoperatively.
  • Results of a skin biopsy disclosed groups of metastatic adenocarcinoma cells in the dermis and subcutaneous tissue, forming clusters and strands in a desmoplastic stroma.

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  • (PMID = 16089312.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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54. Hussein MR: Skin metastasis: a pathologist's perspective. J Cutan Pathol; 2010 Sep;37(9):e1-20
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  • It is one manifestation of systemic spread of cancer.
  • The tumor cells originate either from an internal malignancy or from a primary skin cancer.
  • Generally, skin metastases are encountered in 0.7-9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs.
  • The regional distribution of the skin metastasis, although not always predictable, is related to the location of the primary malignancy and the mechanism of metastatic spread.
  • The relative frequency of skin metastasis correlates with the type of primary cancer, which occurs in each sex.
  • The anterior chest wall and the abdomen are the most commonly involved sites in women.

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  • (PMID = 19922483.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Denmark
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55. Jani AB: Management strategies for locally advanced prostate cancer. Drugs Aging; 2006;23(2):119-29
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  • [Title] Management strategies for locally advanced prostate cancer.
  • Locally advanced prostate cancer represents a subpopulation of prostate cancer diagnosed in patients who are either untouched by screening efforts or whose disease has an unusually rapidly progressive natural history.
  • The typical metastatic work-up consists of a serum alkaline phosphatase, bone scan, CT of the abdomen/pelvis, and chest x-ray.
  • Once metastatic disease has been ruled out, individual components of the management of locally advanced prostate cancer patients may include surgery (palliative or curative), external beam radiation therapy (with photons or particles) or brachytherapy (with low-dose rate/permanent or high-dose rate/temporary radiation sources), and hormone therapy.
  • Unlike in early stage disease, observation/watchful waiting is typically not a treatment option in locally advanced prostate cancer.
  • Finally, novel investigational strategies such as chemotherapy and gene therapy are being applied in an attempt to improve outcomes of locally advanced prostate cancer patients.

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  • (PMID = 16536635.001).
  • [ISSN] 1170-229X
  • [Journal-full-title] Drugs & aging
  • [ISO-abbreviation] Drugs Aging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] New Zealand
  • [Chemical-registry-number] 0 / Androgen Antagonists; 0 / Antineoplastic Agents, Hormonal
  • [Number-of-references] 64
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56. Valenza V, Di Giuda D, Perotti G, Carbone A: Diffuse peritoneal metastases from primary colon cancer demonstrated by Tc-99m-labeled red blood cell scintigraphy. Clin Nucl Med; 2005 Apr;30(4):286-8
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  • [Title] Diffuse peritoneal metastases from primary colon cancer demonstrated by Tc-99m-labeled red blood cell scintigraphy.
  • An 80-year-old man, who underwent complex abdominal surgery for left colon cancer 2 years earlier, was hospitalized because of severe anemia and recurrent episodes of melena.
  • Abdominal ultrasonographic examination and computed tomographic scan failed to detect tumor recurrence or metastatic lesions but moderate ascites was found.
  • Tc-99m red blood cell scintigraphy was performed and disclosed a potential site of intestinal hemorrhage: both dynamic and static images showed a slight but diffuse and persistent uptake of Tc-99m erythrocytes in the entire abdomen with no clear evidence of a site of active bleeding.

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  • (PMID = 15764895.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 7440-26-8 / Technetium
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57. Yi SK, Yoder M, Zaner K, Hirsch AE: Palliative radiation therapy of symptomatic recurrent bladder cancer. Pain Physician; 2007 Mar;10(2):285-90
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  • [Title] Palliative radiation therapy of symptomatic recurrent bladder cancer.
  • RT is effective at palliating both locally advanced and metastatic cancer, including related symptoms of pain, bleeding, or obstruction.
  • With regard to bladder cancer there is some evidence of the benefit of palliative RT for the control of urinary symptoms and hematuria; however, there is little evidence for the use of palliative RT for pain associated with locally recurrent bladder cancer.
  • We report a case of locally advanced recurrent bladder cancer which was refractory to medical pain management, and was found to be highly responsive to palliative RT.
  • CASE REPORT: An 80-year-old woman with recurrent bladder cancer and intractable pelvic pain refractory to oral and transdermal pain medications, received palliative pelvic RT to a dose of 50 Gy (5000 cGy) in 25 fractions with complete resolution of pain.
  • Repeat staging CT of the abdomen and pelvis confirmed tumor recurrence in the left pelvis.
  • CONCLUSIONS: Palliative radiation therapy has been well studied in the setting of bone metastases and treatment of hematuria for locally advanced bladder cancer.
  • There is little data that we are aware of on the use of RT for pain control with patients that have recurrent, locally advanced bladder cancer.
  • RT is an excellent option for pain management in recurrent bladder cancer and should be offered to patients whose pain is not otherwise optimally controlled.
  • Palliative RT is an important component in the multimodality approach to cancer pain management and optimization of quality of life.


58. Salama JK, Chmura SJ, Mehta N, Yenice KM, Stadler WM, Vokes EE, Haraf DJ, Hellman S, Weichselbaum RR: An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease. Clin Cancer Res; 2008 Aug 15;14(16):5255-9
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  • [Title] An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease.
  • PURPOSE: Previous investigations have suggested that a subset of patients with metastatic cancer in a limited number of organs may benefit from local treatment.
  • We investigated whether cancer patients with limited sites of metastatic disease (oligometastasis) who failed standard therapies could be identified and safely treated at one to five known sites of low-volume disease with radiotherapy.
  • EXPERIMENTAL DESIGN: Patients with one to five sites of metastatic cancer with a life expectancy of >3 months and good performance status received escalating doses of radiation to all known sites of cancer with hypofractionated radiation therapy.
  • Patients were followed radiographically with computed tomography scans of the chest, abdomen, and pelvis and metabolically with [18F]fluorodeoxyglucose-positron emission tomography 1 month following treatment and then every 3 months.
  • Acute toxicities were scored using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 and late toxicities were scored using the Radiation Therapy Oncology Group late toxicity scoring system.
  • RESULTS: Twenty-nine patients with 56 metastatic lesions were enrolled from November 2004 to March 2007, with a median follow-up of 14.9 months.
  • CONCLUSIONS: Patients with low-volume metastatic cancer can be identified, safely treated, and may benefit from radiotherapy.

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  • (PMID = 18698045.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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59. Haque W, Crane CH, Krishnan S, Delclos ME, Javle M, Garrett CR, Wolff RA, Das P: Reirradiation to the abdomen for gastrointestinal malignancies. Radiat Oncol; 2009 Nov 18;4:55
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  • [Title] Reirradiation to the abdomen for gastrointestinal malignancies.
  • BACKGROUND: Reirradiation to the abdomen could potentially play a role in palliation of symptoms or local control in patients with gastrointestinal malignancies.
  • Our goal was to retrospectively determine rates of toxicity, freedom from local progression and overall survival in gastrointestinal cancer patients treated with reirradiation to the abdomen.
  • METHODS: Between November 2002 and September 2008, 13 patients with a prior history of abdominal radiotherapy (median dose 45 Gy) were treated with reirradiation for recurrent or metastatic gastrointestinal malignancies.
  • CONCLUSION: Hyperfractionated accelerated reirradiation to the abdomen was well-tolerated with low rates of acute and late toxicity.
  • Reirradiation could play a role in providing a limited duration of local control in gastrointestinal cancer patients with a history of prior abdominal radiotherapy.

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  • (PMID = 19922641.001).
  • [ISSN] 1748-717X
  • [Journal-full-title] Radiation oncology (London, England)
  • [ISO-abbreviation] Radiat Oncol
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA16672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2787526
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60. Remzi FH, Kirat HT, Geisler DP: Laparoscopic single-port colectomy for sigmoid cancer. Tech Coloproctol; 2010 Sep;14(3):253-5
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  • [Title] Laparoscopic single-port colectomy for sigmoid cancer.
  • Herein, we report a patient with a sigmoid colon cancer undergoing single-port laparoscopic sigmoid colectomy.
  • METHODS: Laparoscopic single-port sigmoid colectomy through a 3-cm umbilical incision was performed on a patient with a diagnosis of sigmoid cancer.
  • Abdomen and pelvis CT also found no evidence of recurrence or metastatic disease.
  • It can also be performed with good surgical and oncologic results in selected patients with a colorectal cancer.

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  • (PMID = 19953288.001).
  • [ISSN] 1128-045X
  • [Journal-full-title] Techniques in coloproctology
  • [ISO-abbreviation] Tech Coloproctol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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61. Grewal RK, Tuttle RM, Fox J, Borkar S, Chou JF, Gonen M, Strauss HW, Larson SM, Schöder H: The effect of posttherapy 131I SPECT/CT on risk classification and management of patients with differentiated thyroid cancer. J Nucl Med; 2010 Sep;51(9):1361-7
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  • [Title] The effect of posttherapy 131I SPECT/CT on risk classification and management of patients with differentiated thyroid cancer.
  • The indication for treatment was postsurgical ablation (n = 109) or recurrent or metastatic disease with rising thyroglobulin levels (n = 39).
  • Additional SPECT/CT scans of the abdomen or pelvis were acquired if suggestive findings were noted on planar images.
  • For metastatic disease in the neck, characterization of (131)I uptake by SPECT/CT in the postsurgical group was significantly better than that by planar scanning (P < 0.01).

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  • (PMID = 20720058.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Iodine Radioisotopes
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62. Wilson NM, Espirito JL, Valero V, Pusztai L: Paclitaxel-induced sickle cell crisis. Am J Health Syst Pharm; 2008 Jul 15;65(14):1333-6
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  • PURPOSE: A case of paclitaxel-induced painful crisis in a patient with breast cancer and hemoglobin sickle cell disease (SCD) is reported.
  • She was not taking any medications and did not report a history of cancer or other diseases.
  • Bone scans and computed tomography scans of her chest and abdomen did not reveal any metastatic disease.
  • She underwent a routine left segmental mastectomy and axillary lymph node dissection that revealed a 4-cm invasive cancer with 1 of 10 axillary lymph nodes positive for metastatic disease.
  • CONCLUSION: A patient with breast cancer and SCD had a painful crisis after receiving paclitaxel as part of her chemotherapy regimen.

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  • [ErratumIn] Am J Health Syst Pharm. 2008 Aug 15;65(16):1491
  • (PMID = 18593679.001).
  • [ISSN] 1535-2900
  • [Journal-full-title] American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • [ISO-abbreviation] Am J Health Syst Pharm
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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63. Stakia P, Lagos P, Gourgiotis S, Tzilalis VD, Aloizos S, Salemis NS: Large mass affecting retroperitoneal great vessels: a rare presentation of a cancer of unknown primary with diagnostic dilemma and challenged surgical intervention. J Gastrointest Cancer; 2009;40(1-2):55-8
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  • [Title] Large mass affecting retroperitoneal great vessels: a rare presentation of a cancer of unknown primary with diagnostic dilemma and challenged surgical intervention.
  • They are metastatic solid tumors whose fundamental characteristic is the absence of identifiable site of the primary tumor.
  • CASE REPORT: We report the case of a completely asymptomatic 34-year-old man with a palpated huge mass found incidentally in the left abdomen.
  • A complete resection of the mass was performed while the histological examination revealed a solitary retroperitoneal lymph node categorized as metastatic adenocarcinoma of unknown primary site.
  • CONCLUSION: It is essential to assess the high incidence of patients with cancer who present with CUP.
  • Early surgical excision of the metastatic lesion followed by adjuvant combination chemotherapy should be considered for patients with only a single site of malignancy.

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  • (PMID = 19513858.001).
  • [ISSN] 1941-6636
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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64. Pavel ME, Baum U, Hahn EG, Hensen J: Doxorubicin and streptozotocin after failed biotherapy of neuroendocrine tumors. Int J Gastrointest Cancer; 2005;35(3):179-85
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  • PATIENTS AND METHODS: In 10 patients with metastatic neuroendocrine tumors (4 foregut, 3 midgut, 1 retroperitoneal, and 2 of unknown origin) streptozotocin and doxorubicin were used as second-line or third-line therapy.
  • Tumor response was assessed by computed tomography of the abdomen and thorax and measurement of tumor secretion products (serum chromogranin A, urinary 5-hydroxyindoleacetic acid).

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  • (PMID = 16110119.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 5W494URQ81 / Streptozocin; 80168379AG / Doxorubicin
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65. Coenegrachts K: Magnetic resonance imaging of the liver: New imaging strategies for evaluating focal liver lesions. World J Radiol; 2009 Dec 31;1(1):72-85
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  • The resection of liver metastases of some malignancies (including colorectal cancer) has been shown to improve the survival of patients.
  • Although the primary modalities for liver imaging are ultrasound and computed tomography, recent studies have suggested that MRI is the most sensitive method for detecting small liver metastatic lesions, and MRI is now considered the pre-operative standard method for diagnosis.
  • Two recent developments in MRI sequences for the upper abdomen comprise unenhanced diffusion-weighted imaging (DWI), and keyhole-based dynamic contrast-enhanced (DCE) MRI (4D THRIVE).

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  • (PMID = 21160723.001).
  • [ISSN] 1949-8470
  • [Journal-full-title] World journal of radiology
  • [ISO-abbreviation] World J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2999307
  • [Keywords] NOTNLM ; 4D THRIVE / Contrast agents / Diffusion-weighted magnetic resonance imaging / Dynamic contrast-enhanced magnetic resonance imaging / Liver neoplasms / Magnetic resonance imaging
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66. Kyriazi MA, Sofoudis C, Katsouri M, Kappos T, Zafeiris C, Trihia E, Diamantopoulos P, Nomikos IN: Acute cholangitis due to pancreatic metastasis from squamous cell lung carcinoma: a case report and review of literature. Cases J; 2009;2:9113
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  • INTRODUCTION: The pancreas is a well-documented but relatively uncommon site of non-small-cell cancer metastases.
  • CT scan imaging of the abdomen and chest revealed an abnormal growth of the pancreatic head and distention of both the intra- and extra-hepatic billiary tree, whereas osteolytic abnormalities were observed of the 5th left rib, consistent with secondary deposits.
  • CONCLUSION: Symptomatic metastatic lesions of the pancreas from squamous cell carcinoma of the lung are infrequent.
  • A high index of suspicion is the only way of early detection and potentially effective treatment for this rare localization of metastatic squamous lung carcinoma.

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  • (PMID = 20062690.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2803910
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67. Farma JM, Santillan AA, Melis M, Walters J, Belinc D, Chen DT, Eikman EA, Malafa M: PET/CT fusion scan enhances CT staging in patients with pancreatic neoplasms. Ann Surg Oncol; 2008 Sep;15(9):2465-71
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  • METHODS: Eighty-two patients with potentially resectable PN underwent staging with PET/CT and CT of the chest and abdomen.
  • Sensitivity of diagnosing pancreatic cancer by PET/CT avidity was evaluated.
  • RESULTS: The sensitivity and specificity of PET/CT in diagnosing pancreatic cancer were 89% and 88%, respectively.
  • Sensitivity of detecting metastatic disease for PET/CT alone, standard CT alone, and the combination of PET/CT and CT were 61%, 57%, and 87%, respectively.
  • PET/CT increased sensitivity (87%) for detection of metastatic disease when combined with standard CT.
  • In invasive cancer, PET/CT changed the management in 11% of our patients.

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  • (PMID = 18551347.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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68. Durai R, Ruhomauly SN, Wilson E, Hoque H: Metastatic renal cell carcinoma presenting as a breast lump in a treated breast cancer patient. Singapore Med J; 2009 Aug;50(8):e277-9
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  • [Title] Metastatic renal cell carcinoma presenting as a breast lump in a treated breast cancer patient.
  • Metastatic malignancy in the breast is uncommon.
  • A 68-year-old woman with a past medical history of breast cancer presented with a lump in the opposite breast.
  • The histology on the breast core biopsy showed it to be a metastatic renal cell carcinoma.
  • Subsequent computed tomography of the abdomen confirmed a renal primary tumour.


69. Alvarez Laso C, Paredes Aracil E, Azcano González E, Ots Gutiérrez JR, Bernabeu Miralles M, Compañ Rosique A: Small bowel occlusion due to intussusception of a single metastasis of lung cancer. Clin Transl Oncol; 2006 Nov;8(11):833-4
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  • [Title] Small bowel occlusion due to intussusception of a single metastasis of lung cancer.
  • The occurrence of small bowel intussusception due to metastatic lung cancer is very infrequent.
  • We present a case of young man recently diagnosed of non small cell lung cancer that had a unique small intestine metastasis.
  • [MeSH-minor] Abdomen, Acute / etiology. Humans. Male. Middle Aged. Spinal Neoplasms / secondary

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  • (PMID = 17134974.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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70. Shivnani SB, Shelton JM, Richardson JA, Maalouf NM: Hypercalcemia of malignancy with simultaneous elevation in serum parathyroid hormone--related peptide and 1,25-dihydroxyvitamin D in a patient with metastatic renal cell carcinoma. Endocr Pract; 2009 Apr;15(3):234-9
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  • [Title] Hypercalcemia of malignancy with simultaneous elevation in serum parathyroid hormone--related peptide and 1,25-dihydroxyvitamin D in a patient with metastatic renal cell carcinoma.
  • OBJECTIVE: To determine the cause of refractory hypercalcemia in a patient with metastatic renal cell carcinoma.
  • METHODS: We describe the clinical, pathologic, and immunostain findings in a patient with metastatic renal cell carcinoma and hypercalcemia of malignancy refractory to intravenous bisphosphonates.
  • Computed tomographic scan of the chest and abdomen demonstrated numerous ring-enhancing lesions in the liver, and histologic examination of a biopsy specimen revealed liver tissue infiltrated by a malignant neoplasm composed of cells with clear and eosinophilic cytoplasm, arranged in tubules and nests.

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  • (PMID = 19364692.001).
  • [ISSN] 1934-2403
  • [Journal-full-title] Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • [ISO-abbreviation] Endocr Pract
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / K23 RR021710; United States / NCRR NIH HHS / RR / K23 RR021710-04; United States / NIDDK NIH HHS / DK / P30DK079328; United States / NIDDK NIH HHS / DK / T32-DK07307
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Parathyroid Hormone-Related Protein; 1406-16-2 / Vitamin D; 66772-14-3 / 1,25-dihydroxyvitamin D
  • [Other-IDs] NLM/ NIHMS334951; NLM/ PMC4237065
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71. Brookes M, MacVicar D, Husband J: Metastatic carcinoma of the breast: the appearances of metastatic spread to the abdomen and pelvis as demonstrated by CT. Br J Radiol; 2007 Apr;80(952):284-92
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  • [Title] Metastatic carcinoma of the breast: the appearances of metastatic spread to the abdomen and pelvis as demonstrated by CT.
  • This review illustrates some CT appearances of metastatic breast cancer in the subdiaphragmatic abdomen and pelvis.
  • Such manifestations are not uncommon in advanced disease and familiarity will enable confident diagnosis in patients at risk for metastatic disease.

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  • (PMID = 17038411.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 32
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72. Rifaat MA, Abdel Gawad WS: The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation. J Egypt Natl Canc Inst; 2005 Sep;17(3):139-48
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  • As a pedicled flap its reach to the lower abdomen and groin made it an attractive option for reconstructing soft tissue defects after tumor ablation.
  • RESULTS: The resulting soft tissue defects in this study were due to resection of 4 abdominal wall desmoid tumors, a colonic carcinoma infiltrating the abdominal wall, 4 primary groin soft tissue sarcomas, a metastatic SCC of the leg to groin nodes, and a primary SCC of the groin.

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  • (PMID = 16799651.001).
  • [ISSN] 1110-0362
  • [Journal-full-title] Journal of the Egyptian National Cancer Institute
  • [ISO-abbreviation] J Egypt Natl Canc Inst
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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73. Spitzer SG, Bersani TA, Mejico LJ: Multiple bilateral extraocular muscle metastases as the initial manifestation of breast cancer. J Neuroophthalmol; 2005 Mar;25(1):37-9
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  • [Title] Multiple bilateral extraocular muscle metastases as the initial manifestation of breast cancer.
  • A 75-year-old woman had gradually progressive binocular diplopia and 2 months later had breast cancer diagnosed.
  • A right orbital biopsy was consistent with metastatic breast carcinoma.
  • Positron emission tomography, bone scan, and computed tomography of the chest, abdomen, and pelvis failed to disclose other evidence of breast cancer metastases.
  • It is unusual to encounter metastatic breast cancer affecting every extraocular muscle before the diagnosis of the primary carcinoma.

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  • (PMID = 15756132.001).
  • [ISSN] 1070-8022
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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74. Thamilselvan V, Craig DH, Basson MD: FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J; 2007 Jun;21(8):1730-41
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  • [Title] FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway.
  • Cancer cell adhesion is traditionally viewed as random, occurring if the cell's receptors match the substrate.
  • Cancer cells are subjected to pressure and shear during growth against a constraining stroma, surgical manipulation, and passage through the venous and lymphatic system.
  • Cells shed into a cavity such as the abdomen postoperatively also experience increased pressure from postoperative edema.
  • Increased extracellular pressure stimulates integrin-mediated cancer cell adhesion via FAK and Src.
  • These results delineate a novel force-activated inside-out Src/PI3K/FAK/Akt pathway by which cancer cells regulate their own adhesion.
  • These signals may be potential targets for inhibition of metastatic adhesion.

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  • (PMID = 17317726.001).
  • [ISSN] 1530-6860
  • [Journal-full-title] FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • [ISO-abbreviation] FASEB J.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / R01 DK60771
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Integrins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.10.2 / Focal Adhesion Kinase 1; EC 2.7.10.2 / PTK2 protein, human; EC 2.7.10.2 / Proto-Oncogene Proteins pp60(c-src); EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
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75. Abbas A, Yang G, Fakih M: Management of anal cancer in 2010. Part 1: Overview, screening, and diagnosis. Oncology (Williston Park); 2010 Apr 15;24(4):364-9
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  • [Title] Management of anal cancer in 2010. Part 1: Overview, screening, and diagnosis.
  • Although anal cancer is a rare disease, its incidence is increasing in men and women worldwide.
  • Anal cancer is generally preceded by high-grade anal intraepithelial neoplasia (HGAIN), which is most prevalent in human immunodeficiency virus (HIV)-positive men who have sex with men.
  • Nearly half of all patients with anal cancer present with rectal bleeding.
  • According to the Surveillance Epidemiology and End Results (SEER) database, 50% of patients with anal cancer have disease localized to the anus, 29% have regional lymph node involvement or direct spread beyond the primary, and 12% have metastatic disease, while 9% have an unknown stage.
  • Clinical staging of anal carcinoma requires a digital rectal exam and a computed tomography scan of the chest, abdomen, and pelvis.
  • The 5-year relative survival rates are 80.1% for localized anal cancer, 60.7% for regional disease, and 29.4% for metastatic disease.
  • Part 2 of this two-part review will address the treatment of anal cancer, highlighting studies of chemoradiation.

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  • (PMID = 20464850.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 94
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76. Boughanim M, Leboulleux S, Rey A, Pham CT, Zafrani Y, Duvillard P, Lumbroso J, Haie-Meder C, Schlumberger M, Morice P: Histologic results of para-aortic lymphadenectomy in patients treated for stage IB2/II cervical cancer with negative [18F]fluorodeoxyglucose positron emission tomography scans in the para-aortic area. J Clin Oncol; 2008 May 20;26(15):2558-61
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  • [Title] Histologic results of para-aortic lymphadenectomy in patients treated for stage IB2/II cervical cancer with negative [18F]fluorodeoxyglucose positron emission tomography scans in the para-aortic area.
  • PATIENTS AND METHODS: Patients were treated between 2004 and 2006 for stage IB2/II cervical cancer.
  • Magnetic resonance imaging of the abdomen and pelvis and FDG-PET/CT were initially performed.
  • Three patients had histologically proven para-aortic involvement (metastatic nodes with capsular rupture in the para-aortic area), leading to a negative predictive value of 92% for para-aortic nodal involvement.
  • PET/CT imaging without histologic examination of the para-aortic area used to determine radiation therapy fields in stage IB2/II cervical cancer would overlook 8% of patients with histologic para-aortic nodal involvement.


77. Bradley S, Dumas N, Ludman M, Wood L: Hereditary renal cell carcinoma associated with von Hippel-Lindau disease: a description of a Nova Scotia cohort. Can Urol Assoc J; 2009 Feb;3(1):32-6
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  • Of the 6 patients with RCC, 4 had bilateral tumours, 2 required kidney transplants and 1 developed metastatic disease.
  • Routine surveillance was being done for the CNS in 62.5% of patients, retina in 47.4%, abdomen in 43.8% and urine catecholamines in only 10.5%.

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  • (PMID = 19293973.001).
  • [ISSN] 1911-6470
  • [Journal-full-title] Canadian Urological Association journal = Journal de l'Association des urologues du Canada
  • [ISO-abbreviation] Can Urol Assoc J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2645893
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78. Chand M, Thomas RJ, Dabbas N, Bateman AC, Royle GT: Soft Tissue Metastases as the First Clinical Manifestation of Squamous Cell Carcinoma of the Esophagus: Case Report. World J Oncol; 2010 Jun;1(3):135-137
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  • A 73-year-old woman presented with a soft swelling in the left upper quadrant of the abdomen arising from the anterior abdominal wall, suspicious of liposarcoma.
  • Immunohistochemistry suggested the most likely diagnosis was that of metastatic carcinoma with a number of potential primary sites.
  • Computed tomography scanning showed widespread metastatic disease, including lung, liver, kidney, omentum, subcutaneous and intramuscular lesions.
  • Soft-tissue metastases are rarely encountered as a presenting sign of an occult cancer.

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  • [Cites] Ann Plast Surg. 1993 Oct;31(4):377-8 [8239441.001]
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  • (PMID = 29147193.001).
  • [ISSN] 1920-454X
  • [Journal-full-title] World journal of oncology
  • [ISO-abbreviation] World J Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Keywords] NOTNLM ; Biopsy / Esophagus / Occult cancer / Soft tissue metastasis / Squamous cell carcinoma
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79. Khan AH, Thompson CC, Carr-Locke DL: Chronic diarrhea due to metastatic breast cancer. MedGenMed; 2005;7(2):17
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  • [Title] Chronic diarrhea due to metastatic breast cancer.
  • We report the case of a patient with chronic diarrhea due to infiltrative cancer to the colon from the breast.
  • A 49-year-old woman with a history of metastatic breast cancer to the bones was admitted to hospital with 4 weeks of watery diarrhea.
  • Computed tomography (CT) scan of the abdomen showed pancolitis.


80. Pan M, Santamaria M, Wollman DB: CNS response after erlotinib therapy in a patient with metastatic NSCLC with an EGFR mutation. Nat Clin Pract Oncol; 2007 Oct;4(10):603-7
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  • [Title] CNS response after erlotinib therapy in a patient with metastatic NSCLC with an EGFR mutation.
  • INVESTIGATIONS: Physical examination, brain MRI, CT scans of the chest, abdomen and pelvis, bone scan, CT scan-guided biopsy, hematoxylin and eosin staining, EGFR mutational analysis, and chest X-ray.
  • DIAGNOSIS: Stage IV non-small-cell lung cancer with brain metastasis.

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  • (PMID = 17898810.001).
  • [ISSN] 1743-4262
  • [Journal-full-title] Nature clinical practice. Oncology
  • [ISO-abbreviation] Nat Clin Pract Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Protein Kinase Inhibitors; 0 / Quinazolines; DA87705X9K / Erlotinib Hydrochloride; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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81. Boone J, Livestro DP, Elias SG, Borel Rinkes IH, van Hillegersberg R: International survey on esophageal cancer: part II staging and neoadjuvant therapy. Dis Esophagus; 2009;22(3):203-10
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  • [Title] International survey on esophageal cancer: part II staging and neoadjuvant therapy.
  • Neoadjuvant therapy could improve outcome by increasing the number of radical resections and by controlling metastatic disease.
  • The purposes of this study were to gain insight into the current worldwide practice of staging modalities and neoadjuvant therapy in esophageal cancer, and to detect intercontinental differences.
  • Questions were asked regarding staging modalities, neoadjuvant therapy, and response evaluation applied in esophageal cancer patients.
  • Esophagogastroscopy with biopsy and computed tomography (CT) scanning were routinely performed by 98% of responders for diagnosing and staging esophageal cancer, while endoscopic ultrasound (EUS) and barium esophagography were routinely applied by 58% and 51%, respectively.
  • Response to neoadjuvant therapy is predominantly assessed by CT scanning of the chest and abdomen (86%).
  • In conclusion, currently the most commonly applied diagnostic modalities for staging and restaging esophageal cancer are CT scanning of the chest and abdomen, gastroscopy, barium esophagography and EUS.
  • Intercontinental differences have been detected in the diagnostic modalities applied in esophageal cancer staging and in the administration of neoadjuvant therapy.

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  • (PMID = 19191855.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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82. Stenzl A, Cowan NC, De Santis M, Jakse G, Kuczyk MA, Merseburger AS, Ribal MJ, Sherif A, Witjes JA: The updated EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol; 2009 Apr;55(4):815-25
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  • [Title] The updated EAU guidelines on muscle-invasive and metastatic bladder cancer.
  • CONTEXT: New data regarding diagnosis and treatment of muscle-invasive and metastatic bladder cancer (MiM-BC) has emerged and led to an update of the European Association of Urology (EAU) guidelines for MiM-BC.
  • EVIDENCE SYNTHESIS: The diagnosis of muscle-invasive bladder cancer (BCa) is made by transurethral resection (TUR) and following histopathologic evaluation.
  • Patients with confirmed muscle-invasive BCa should be staged by computed tomography (CT) scans of the chest, abdomen, and pelvis, if available.
  • In metastatic disease, the first-line treatment for patients fit enough to sustain cisplatin is cisplatin-containing combination chemotherapy.


83. Boyd DT, Hayeri MR, Vyas PK: Supratentorial primitive neuroectodermal tumor metastasis to the abdomen via a ventriculoperitoneal shunt. Pediatr Radiol; 2010 Dec;40 Suppl 1:S123-6
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  • [Title] Supratentorial primitive neuroectodermal tumor metastasis to the abdomen via a ventriculoperitoneal shunt.
  • Infratentorial PNET, or medulloblastoma, is a common brain tumor in children and metastatic spread to the abdomen via a ventriculoperitoneal (VP) shunt has been described.
  • We present a rare case of a predominantly supratentorial PNET metastasizing to the abdomen via a VP shunt and discuss the radiological findings.
  • This case demonstrates the small but real risk of metastatic spread, which should be weighed when considering VP shunt placement.

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  • [ErratumIn] Pediatr Radiol. 2011 Mar;41(3):399
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  • (PMID = 20526591.001).
  • [ISSN] 1432-1998
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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84. Artifon EL, Srougi M, Lucon AM, Sakai P, Bhutani MS: Endoscopic ultrasound with fine-needle aspiration facilitates diagnosis of metastatic iliac lymph node invasion in prostate cancer. Endoscopy; 2009;41 Suppl 2:E243-4
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  • [Title] Endoscopic ultrasound with fine-needle aspiration facilitates diagnosis of metastatic iliac lymph node invasion in prostate cancer.
  • [MeSH-minor] Abdomen. Aged. Humans. Lymphatic Metastasis. Male


85. Guérin E, Gilbert O, Dequanter D: Acute abdomen: a rare presentation of lung cancer metastasis. Case Rep Med; 2009;2009:903897
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  • [Title] Acute abdomen: a rare presentation of lung cancer metastasis.
  • We describe two cases of symptomatic gastrointestinal metastatic small cell carcinoma: the first one concerns a 69-year-old man with an acute abdomen and the second is a 72-year-old man complaining of a gastric ulcer symptoms.

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  • (PMID = 19841757.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2762241
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86. Elisei R, Romei C, Castagna MG, Lisi S, Vivaldi A, Faviana P, Marinò M, Ceccarelli C, Pacini F, Pinchera A: RET/PTC3 rearrangement and thyroid differentiation gene analysis in a struma ovarii fortuitously revealed by elevated serum thyroglobulin concentration. Thyroid; 2005 Dec;15(12):1355-61
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  • Ultrasound examination of the abdomen showed a solid mass of 2 cm in the left ovary.
  • A cancer-free period of 3-4 years, as in our patient, is not long enough to definitively exclude a late onset metastatic disease but, unfortunately, the patient died of nonmedical reasons.

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  • (PMID = 16405408.001).
  • [ISSN] 1050-7256
  • [Journal-full-title] Thyroid : official journal of the American Thyroid Association
  • [ISO-abbreviation] Thyroid
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Transport Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / SLC26A4 protein, human; 9010-34-8 / Thyroglobulin; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / ret-PTC fusion oncoproteins, human
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87. Sandha GS, Severin D, Postema E, McEwan A, Stewart K: Is positron emission tomography useful in locoregional staging of esophageal cancer? Results of a multidisciplinary initiative comparing CT, positron emission tomography, and EUS. Gastrointest Endosc; 2008 Mar;67(3):402-9
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  • [Title] Is positron emission tomography useful in locoregional staging of esophageal cancer? Results of a multidisciplinary initiative comparing CT, positron emission tomography, and EUS.
  • BACKGROUND: Various modalities including CT, positron emission tomography (PET), and EUS are being used for esophageal cancer staging.
  • PATIENTS AND INTERVENTIONS: Patients with esophageal cancer proven by endoscopy and biopsy underwent a CT scan of the chest and abdomen and a PET scan.
  • Patients with no evidence of distant metastatic disease on CT and PET were referred for EUS for locoregional staging.
  • CONCLUSION: EUS is safe and accurate for tumor and node staging in esophageal cancer.
  • The combination of CT plus EUS appears to be accurate for locoregional staging in esophageal cancer.


88. Refae MA, Wong N, Patenaude F, Bégin LR, Foulkes WD: Hereditary leiomyomatosis and renal cell cancer: an unusual and aggressive form of hereditary renal carcinoma. Nat Clin Pract Oncol; 2007 Apr;4(4):256-61
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  • [Title] Hereditary leiomyomatosis and renal cell cancer: an unusual and aggressive form of hereditary renal carcinoma.
  • After an initial biopsy of the neck mass, which revealed metastatic carcinoma, a left radical nephrectomy was performed as well as excision of a left supraclavicular lymph node.
  • Subsequent inquiry revealed that the patient's father had died of metastatic renal cell carcinoma (RCC) at the age of 40 years, and that other family members had also developed skin and uterine leiomyomas.
  • INVESTIGATIONS: Physical examination, CT scans of the chest, abdomen, and pelvis, lymph-node biopsy and genetic counseling, followed by genetic testing.
  • DIAGNOSIS: Papillary type 2 RCC described in the context of hereditary leiomyomatosis and renal cell cancer (HLRCC), an autosomal dominant syndrome attributable to a mutation in the fumarate hydratase (FH) gene on chromosome 1.


89. Gomez-Abuin G, Karam AA, Mezzadri NA, Bas CA: Acalculous cholecystitis in a patient with metastatic renal cell carcinoma treated with sunitinib. Clin Genitourin Cancer; 2009 Jan;7(1):62-3
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  • [Title] Acalculous cholecystitis in a patient with metastatic renal cell carcinoma treated with sunitinib.
  • A 62-year-old woman was treated with sunitinib as a second-line therapy for metastatic clear-cell renal carcinoma.
  • A follow-up computed tomography scan of the abdomen revealed a complete resolution of gallbladder changes.
  • Our patient did not have major risk factors for developing an acalculous cholecystitis except for a relative immunosuppressed state secondary to her advanced renal cancer.

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  • (PMID = 19213671.001).
  • [ISSN] 1558-7673
  • [Journal-full-title] Clinical genitourinary cancer
  • [ISO-abbreviation] Clin Genitourin Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Indoles; 0 / Pyrroles; 0 / sunitinib
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90. Cienki JJ, Zaret L: An Internet misadventure: bloodroot salve toxicity. J Altern Complement Med; 2010 Oct;16(10):1125-7
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  • CASE REPORT 2: A 42-year-old man with a history of metastatic colon cancer developed palpable subcutaneous nodules on the anterior abdominal wall.
  • The patient's mother searched the Internet for cancer salves and purchased black and yellow bloodroot salve.
  • Web sites discuss the efficacy of bloodroot in treating skin cancer.
  • [MeSH-minor] Abdomen / pathology. Adult. Humans. Intestinal Fistula. Male. Melanoma. Middle Aged. Pain / etiology. Phytotherapy / adverse effects. Thorax / pathology

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  • (PMID = 20932193.001).
  • [ISSN] 1557-7708
  • [Journal-full-title] Journal of alternative and complementary medicine (New York, N.Y.)
  • [ISO-abbreviation] J Altern Complement Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts
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91. Dose-Schwarz J, Mahner S, Schirrmacher S, Jenicke L, Müller V, Habermann CR, Brenner W: [Detection of metastases in breast cancer patients: comparison of FDG PET with chest X-ray, bone scintigraphy and ultrasound of the abdomen]. Nuklearmedizin; 2008;47(3):97-103
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  • [Title] [Detection of metastases in breast cancer patients: comparison of FDG PET with chest X-ray, bone scintigraphy and ultrasound of the abdomen].
  • Distant metastases at primary diagnosis are a prognostic key factor in breast cancer patients and play a central role in therapeutic decisions.
  • Although FDG PET detects metastatic disease with high accuracy, its diagnostic value in breast cancer still needs to be defined.
  • PATIENTS, METHODS: A retrospective analysis of 119 breast cancer patients who presented for staging was performed.
  • Regarding different locations of metastases the sensitivity of FDG PET was superior in the detection of pulmonary metastases and lymph node metastases of the mediastinum in comparison to chest x-ray, whereas the sensitivity of FDG PET in the detection of bone and liver metastases was comparable with bone scintigraphy and ultrasound of the abdomen.
  • CONCLUSIONS: FDG-PET is more sensitive than conventional imaging procedures for detection of distant breast cancer metastases and should be considered for additional staging especially in patients with high risk primary breast cancer.
  • [MeSH-major] Abdomen / ultrasonography. Breast Neoplasms / radiography. Breast Neoplasms / radionuclide imaging. Breast Neoplasms / secondary. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods

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  • (PMID = 18493688.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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92. Tamm EP, Kim EE, Ng CS: Imaging of neuroendocrine tumors. Hematol Oncol Clin North Am; 2007 Jun;21(3):409-32; vii
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  • In this article the authors focus on the more common tumors with origins primarily in the abdomen, namely carcinoid, paraganglioma, and pancreatic islet cell tumors.
  • Imaging assists in delineating the sites and extent of disease, in preoperative planning for resection of the primary tumor and metastatic disease, and in follow-up.

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  • (PMID = 17548032.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 82
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93. Sundaram PS, Padma S, Rai JK, Harish V: Staring secondaries, where is the primary? Indian J Med Paediatr Oncol; 2010 Oct;31(4):148-50
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  • An asymptomatic issueless young staff nurse underwent pre-employment health screening and USG abdomen showed multiple hypodense lesions in liver.

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  • [Cites] Radiology. 2004 May;231(2):305-32 [15044750.001]
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  • (PMID = 21584222.001).
  • [ISSN] 0975-2129
  • [Journal-full-title] Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
  • [ISO-abbreviation] Indian J Med Paediatr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3089925
  • [Keywords] NOTNLM ; Metastases / metastatic rhabdomyosarcoma / positron emission tomography-computed tomography imaging / unknown primary / uterine tumor
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94. Corsi F, Sartani A, Rizzi A, Nosenzo MA, Foschi D, Alineri S, Trabucchi E: Primary carcinoma of ectopic breast tissue. Clin Breast Cancer; 2008 Apr;8(2):189-91
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  • A bilateral digital mammography, chest and abdomen computed tomography scan, and a magnetic resonance imaging scan (MRI) of the axillary region were performed.
  • In our case, the MRI was able to exclude the presence of neoplastic tissue in the breast; moreover, it confirmed the presence of metastatic lymph nodes and recognized a second type of nodular lesion in the axilla, showing on the MRI a radiologic pattern similar to breast tissue.

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  • (PMID = 18621617.001).
  • [ISSN] 1526-8209
  • [Journal-full-title] Clinical breast cancer
  • [ISO-abbreviation] Clin. Breast Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Ahmadzadehfar H, Sabet A, Biermann K, Muckle M, Brockmann H, Kuhl C, Wilhelm K, Biersack HJ, Ezziddin S: The significance of 99mTc-MAA SPECT/CT liver perfusion imaging in treatment planning for 90Y-microsphere selective internal radiation treatment. J Nucl Med; 2010 Aug;51(8):1206-12
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  • Selective internal radiation therapy (SIRT), a catheter-based liver-directed modality for treating primary and metastatic liver cancer, requires appropriate planning to maximize its therapeutic response and minimize its side effects. (99m)Tc-macroaggregated albumin (MAA) scanning should precede the therapy to detect any extrahepatic shunting to the lung or gastrointestinal tract.
  • METHODS: Ninety diagnostic hepatic angiograms with (99m)Tc-MAA were obtained for 76 patients with different types of cancer.
  • [MeSH-minor] Abdomen / radionuclide imaging. Adult. Aged. Aged, 80 and over. Data Interpretation, Statistical. Embolization, Therapeutic. Female. Gallbladder / metabolism. Gallbladder / radionuclide imaging. Humans. Image Interpretation, Computer-Assisted. Male. Microspheres. Middle Aged. Patient Care Planning. Radionuclide Angiography. Reference Standards. Tomography, Emission-Computed. Tomography, Emission-Computed, Single-Photon

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  • (PMID = 20660379.001).
  • [ISSN] 1535-5667
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0 / Technetium Tc 99m Aggregated Albumin; 0 / Yttrium Radioisotopes
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96. Bristow AR, Agrawal A, Evans AJ, Burrell HC, Cornford EJ, James JJ, Hamilton L, Robertson JF, Chan SY, Lawton PA, Cheung KL: Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer? A prospective study. Breast; 2008 Feb;17(1):98-103
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  • [Title] Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer? A prospective study.
  • BACKGROUND: The aim of this study was to determine whether bone scans (BS) can be avoided if pelvis was included in CT thorax and abdomen to detect bony metastases from breast cancer.
  • MATERIALS AND METHODS: Results of 77 pairs of CT (thorax, abdomen, and pelvis) and BS in newly diagnosed patients with metastatic breast cancer (MBC) were compared prospectively for 12 months.
  • RESULTS: CT detected metastatic bone lesions in 43 (98%) of 44 patients with bone metastases.
  • CONCLUSION: Our findings suggest routine BS of patients presenting with MBC is not required if CT (thorax, abdomen, and pelvis) is performed.


97. Pandey M, Kumar V, Shukla M, Kumar M: Thyroid swelling in a 32-year-old male. BMJ Case Rep; 2009;2009
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  • A 32-year-old male presented with a 4-month history of thyroid swelling and abdomen pain.
  • The further diagnostic and metastatic work-up identified a diffuse carcinoma of the stomach as the primary site with liver as secondary and retroperitoneal lymph nodes having mucinous deposits with associated Peutz-Jeghers polyposis.

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  • (PMID = 21686341.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3028274
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98. Wedmid A, Masterson TA, Maki RG, Russo P: A case of high-risk penile epithelioid hemangioendothelioma. Nat Rev Urol; 2009 Apr;6(4):223-7
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  • CT of the chest, abdomen and pelvis was negative for metastatic disease.

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  • (PMID = 19352397.001).
  • [ISSN] 1759-4820
  • [Journal-full-title] Nature reviews. Urology
  • [ISO-abbreviation] Nat Rev Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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99. Rajendran S, Salwa S, Gao X, Tabirca S, O'Hanlon D, O'Sullivan GC, Tangney M: Murine bioluminescent hepatic tumour model. J Vis Exp; 2010;(41)
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  • The other hemi-spleen is left intact and returned to the abdomen.
  • This mouse model allows for investigating the mechanisms underlying metastatic tumour-cell survival and growth and can be used for the evaluation of therapeutics of liver metastasis.

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  • (PMID = 20689502.001).
  • [ISSN] 1940-087X
  • [Journal-full-title] Journal of visualized experiments : JoVE
  • [ISO-abbreviation] J Vis Exp
  • [Language] eng
  • [Publication-type] Journal Article; Video-Audio Media
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3156080
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100. de Reijke TM, Bellmunt J, van Poppel H, Marreaud S, Aapro M: EORTC-GU group expert opinion on metastatic renal cell cancer. Eur J Cancer; 2009 Mar;45(5):765-73
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  • [Title] EORTC-GU group expert opinion on metastatic renal cell cancer.
  • There is no consensus on the detailed surveillance of renal cell cancer (RCC) patients after radical resection of the kidney.
  • These investigations could be supplemented by annual computerised tomography (CT) of the chest and abdomen.
  • Since the emergence of new and more effective treatments for metastatic disease, follow-up has tended to become more challenging not only with respect to disease assessment but also for evaluation of toxicity [Level 5].
  • The diagnostic work-up in metastatic RCC should include a history, physical examination and comprehensive blood screen.
  • Metastatic RCC responds, albeit at a low rate, to cytokines.
  • Choice of initial medical management in patients with metastatic clear-cell RCC should be guided by the pivotal, randomised studies.

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  • (PMID = 19157861.001).
  • [ISSN] 1879-0852
  • [Journal-full-title] European journal of cancer (Oxford, England : 1990)
  • [ISO-abbreviation] Eur. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents
  • [Number-of-references] 71
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