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1. Krambeck FJ, Bennun SV, Narang S, Choi S, Yarema KJ, Betenbaugh MJ: A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data. Glycobiology; 2009 Nov;19(11):1163-75
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  • The method was applied to mass spectrometric data of normal human monocytes and monocytic leukemia (THP1) cells to derive glycosyltransferase activity changes underlying the differences in glycan structure between the normal and diseased cells.

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  • (PMID = 19506293.001).
  • [ISSN] 1460-2423
  • [Journal-full-title] Glycobiology
  • [ISO-abbreviation] Glycobiology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / 5R41CA127885-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Polysaccharides; EC 2.4.- / Glycosyltransferases
  • [Other-IDs] NLM/ PMC2757573
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2. Sagawa M, Shimizu T, Shimizu T, Awaya N, Mitsuhashi T, Ikeda Y, Okamoto S, Kizaki M: Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15. Leukemia; 2006 Sep;20(9):1566-71
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  • [Title] Establishment of a new human acute monocytic leukemia cell line TZ-1 with t(1;11)(p32;q23) and fusion gene MLL-EPS15.
  • Human leukemia cell lines are of great value in investigating basic and applied aspects of cell biology and clinical medicine.
  • There have been 37 leukemia cell lines carrying 11q23 translocation and MLL rearrangements; however, cell lines harboring with t(1;11)(p32;q23) have not been established.
  • We report here for the first time a new acute monocytic leukemia (AMoL) cell line with t(1;11)(p32;q23), designated TZ-1, and herein describe its biological characteristics.
  • Mononuclear cells isolated from the ascites from a patient with AMoL (French-American-British classification; acute myeloid leukemia M5a) were isolated and passaged by liquid culture medium for a year.
  • TZ-1 cells revealed typical monocytic features in morphology and had a t(1;11)(p32;q23) translocation.
  • The immunoprofiling as determined by flow cytometry showed that TZ-1 cells are positive for myeloid and monocytic markers with lymphoid-associated markers.
  • Taken together, these results suggest that TZ-1 is a new monocytic leukemia cell line with t(1;11) translocation and fusion gene MLL-EPS15.
  • The established cell line, TZ-1, could provide a valuable model in the analysis of the pathogenesis of MLL-EPS15-positive leukemia and in the development of new agents for this type of leukemia.
  • [MeSH-major] Chromosomes, Human, Pair 1. Chromosomes, Human, Pair 11. Leukemia, Monocytic, Acute / pathology. Translocation, Genetic

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  • (PMID = 16826222.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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3. Martínez-Poventud G, Fradera J, Pérez S, Fernández A, Pacheco E, Acabá L, López-Enriquez A, Román-Díaz A, Castro-Montalvo J, Vélez-García E: Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. P R Health Sci J; 2008 Sep;27(3):256-8
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  • [Title] Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report.
  • Aleukemic leukemia cutis is an extremely rare clinical presentation in patients who eventually develop acute leukemia, usually of monocytic lineage.
  • We report a case of a 33 years old female with leukemia cutis preceding the onset of acute monocytic leukemia by four months.
  • To our knowledge, this is the first documented case in Puerto Rico with the diagnosis of leukemia cutis preceding acute monocytic leukemia.
  • [MeSH-major] Leukemia, Monocytic, Acute / pathology. Leukemic Infiltration. Skin / pathology

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  • (PMID = 18782972.001).
  • [ISSN] 0738-0658
  • [Journal-full-title] Puerto Rico health sciences journal
  • [ISO-abbreviation] P R Health Sci J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Puerto Rico
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4. Ji YY, Zhang WG, Chen YX, Zhao XM, He AL, Liu J, Wang JL, Wang FX, Zhang PY, Zhang WJ: [Efficiency of GHA priming therapy on patients with acute monocytic leukemia and its mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2010 Feb;18(1):213-8
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  • [Title] [Efficiency of GHA priming therapy on patients with acute monocytic leukemia and its mechanism].
  • The aim of this study was to explore the clinical efficiency and side effects of GHA-priming therapy on patients with acute monocytic leukemia, and to analyze its mechanism.
  • 37 patients with refractory, relapse, hypocellular acute monocytic leukemia and elderly patients with AML-M(5) were treated with GHA-priming therapy (G-CSF, homoharringtonine and low dosage of cytarabine).
  • Other non-hematological toxicities were low in vitro when incubated with G-CSF for 24 hours, the S-phase cells obviously increased.
  • It is concluded that the GHA priming therapy can be used to treat patients with refractory, relapse, senile and hypocellular acute monocytic leukemia with satisfied response rate and low hematological and non-hematological toxicities.
  • MLAA-34 is a novel anti-apoptotic factor of acute monocytic leukemia.

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  • (PMID = 20137150.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] Clinical Trial; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Harringtonines; 04079A1RDZ / Cytarabine; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 6FG8041S5B / homoharringtonine
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5. Tone A, Shikata K, Ogawa D, Sasaki S, Nagase R, Sasaki M, Yozai K, Usui HK, Okada S, Wada J, Shikata Y, Makino H: Changes of gene expression profiles in macrophages stimulated by angiotensin II--angiotensin II induces MCP-2 through AT1-receptor. J Renin Angiotensin Aldosterone Syst; 2007 Mar;8(1):45-50
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  • Angiotensin II type 1 receptor antagonists (AIIA) are beneficial for the prevention of atherosclerosis and diabetic nephropathy suggesting that angiotensin II (Ang II) promotes the development of these diseases.
  • MATERIALS AND METHODS: PMA-treated THP-1 cells, a human monocytic leukaemia cell line, were treated with Ang II (10-6 mol/L) for 24 hours with or without AIIA (CV11974).
  • [MeSH-major] Angiotensin II / pharmacology. Macrophages / physiology. Monocyte Chemoattractant Proteins / genetics. Receptor, Angiotensin, Type 1 / genetics. Vasoconstrictor Agents / pharmacology
  • [MeSH-minor] Cell Line, Tumor. Chemokine CCL8. Chemokines / genetics. Cytokines / genetics. Gene Expression / drug effects. Gene Expression / immunology. Gene Expression Profiling. Humans. Leukemia, Monocytic, Acute. Monocytes / cytology. Monocytes / drug effects. Monocytes / physiology. Oligonucleotide Array Sequence Analysis. Receptor, Angiotensin, Type 2 / genetics

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  • (PMID = 17487826.001).
  • [ISSN] 1470-3203
  • [Journal-full-title] Journal of the renin-angiotensin-aldosterone system : JRAAS
  • [ISO-abbreviation] J Renin Angiotensin Aldosterone Syst
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CCL8 protein, human; 0 / Chemokine CCL8; 0 / Chemokines; 0 / Cytokines; 0 / Monocyte Chemoattractant Proteins; 0 / Receptor, Angiotensin, Type 1; 0 / Receptor, Angiotensin, Type 2; 0 / Vasoconstrictor Agents; 11128-99-7 / Angiotensin II
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6. Peng B, Xu L, Cao F, Wei T, Yang C, Uzan G, Zhang D: HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way. Mol Cancer; 2010;9:79
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  • [Title] HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.
  • In this study, we observed the effects of celastrol on the human monocytic leukemia cell line U937 cell cycle.

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  • (PMID = 20398364.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cell Cycle Proteins; 0 / HSP90 Heat-Shock Proteins; 0 / Sulfhydryl Compounds; 0 / Triterpenes; 34157-83-0 / tripterine
  • [Other-IDs] NLM/ PMC2873437
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7. Imataki O, Ohnishi H, Yamaoka G, Arai T, Kitanaka A, Kubota Y, Kushida Y, Ishida T, Tanaka T: Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse. Int J Clin Oncol; 2010 Feb;15(1):112-5
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  • [Title] Lineage switch from precursor B cell acute lymphoblastic leukemia to acute monocytic leukemia at relapse.
  • A lineage switch in leukemia, in which the leukemic cell lineage at onset converts to another lineage at a later time, is an uncommon type of hybrid (mixed) leukemia regarded as a variation of bilineage leukemia.
  • We present a case of a 60-year-old female diagnosed with precursor B cell acute lymphoblastic leukemia (ALL), whose markers in flow cytometry shifted from their original status of CD19+, 22+, 79a+, 13+, HLA-DR+, and TdT+.
  • Two weeks after liver biopsy, blast cells progressively appeared in the peripheral blood; these cells had a monocytoid morphology and phenotype (CD13, 14) but were accompanied by myeloid (CD33) and lymphoid (CD2, 4, 20) cells.
  • This phenotypical conversion from B-ALL to hybrid leukemia featuring monocytoid characteristics is known as a lineage switch.
  • [MeSH-major] Leukemia, Biphenotypic, Acute / pathology. Leukemia, Monocytic, Acute / pathology. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology

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  • (PMID = 20066454.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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8. Hahn M, Li W, Yu C, Rahmani M, Dent P, Grant S: Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. Mol Cancer Ther; 2005 Mar;4(3):457-70
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  • [Title] Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways.
  • Interactions between the protein kinase C and Chk1 inhibitor UCN-01 and rapamycin in human leukemia cells have been investigated in relation to apoptosis induction.
  • Treatment of U937 monocytic leukemia cells with rapamycin (10 nmol/L) in conjunction with a minimally toxic concentration of UCN-01 (100 nmol/L) for 36 hours resulted in marked potentiation of mitochondrial injury (i.e., loss of mitochondrial membrane potential and cytosolic release of cytochrome c, AIF, and Smac/DIABLO), caspase activation, and apoptosis.
  • Together, these findings indicate that the mammalian target of rapamycin inhibitor potentiates UCN-01 cytotoxicity in a variety of human leukemia cell types and suggest that inhibition of both Raf-1/MEK/ERK and Akt cytoprotective signaling pathways as well as JNK activation contribute to this phenomenon.
  • [MeSH-major] Apoptosis. Extracellular Signal-Regulated MAP Kinases / metabolism. JNK Mitogen-Activated Protein Kinases / metabolism. Leukemia / drug therapy. MAP Kinase Kinase 1 / metabolism. Mitogen-Activated Protein Kinase Kinases / metabolism. Protein-Serine-Threonine Kinases / metabolism. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-raf / metabolism. Sirolimus / pharmacology. Staurosporine / analogs & derivatives. Staurosporine / pharmacology


9. Katsumoto T, Aikawa Y, Iwama A, Ueda S, Ichikawa H, Ochiya T, Kitabayashi I: MOZ is essential for maintenance of hematopoietic stem cells. Genes Dev; 2006 May 15;20(10):1321-30
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  • Monocytic leukemia zinc-finger protein (MOZ), a MYST family histone acetyltransferase, is involved in the chromosome translocations associated with acute myeloid leukemia.
  • [MeSH-minor] Animals. B-Lymphocytes / cytology. Cell Differentiation / genetics. Down-Regulation. Embryonic Development / genetics. Genes, Lethal. Homeodomain Proteins / genetics. Leukemia / genetics. Liver / cytology. Liver / growth & development. Mice. Mice, Mutant Strains. Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Proto-Oncogene Proteins c-kit / genetics. Receptors, Cytokine / genetics. Receptors, Thrombopoietin. Trans-Activators / metabolism. Transcriptional Activation


10. Chen YX, Wang WP, Zhang PY, Zhang WG, Liu J, Ma XR: [Expression of genes psma6 and slc25a4 in patients with acute monocytic leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2009 Oct;17(5):1168-73
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  • [Title] [Expression of genes psma6 and slc25a4 in patients with acute monocytic leukemia].
  • The aim of this study was to investigate the expression levels of genes psma6 and slc25a4 in bone marrow of patients with acute monocytic leukemia and their correlation with clinical features and prognosis.
  • The expression levels of genes psma6 and slc25a4 in AML-M5 leukemia cells, normal blood cells and non-leukemia cells were detected by real-time quantitative RT-PCR and compared each other.
  • The results showed that the expression levels of psma6 mRNA in AML-M5 leukemia cells was lower than that in non AML-M5 leukemia cells, non-leukemia cells and normal blood cells.
  • It is concluded that the expression level of psma6 is probably a new prognostic indicator of acute monocytic leukemia, slc25a4 may be a novel gene of antigen associated with acute monocytic leukemia.

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  • (PMID = 19840444.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Adenine Nucleotide Translocator 1; EC 3.4.25.1 / PSMA6 protein, human; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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11. Ho TC, Yang YC, Chen SL, Kuo PC, Sytwu HK, Cheng HC, Tsao YP: Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma. Mol Immunol; 2008 Feb;45(4):898-909
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  • Here we report that PEDF can also induce the apoptosis of human THP-1 monocytic leukemia cell line-derived macrophage cells (THP-1 macrophages) and peroxisome proliferator-activated receptor gamma (PPARgamma), a pleiotropic transcriptional factor is involved in the signaling.

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  • (PMID = 17870167.001).
  • [ISSN] 0161-5890
  • [Journal-full-title] Molecular immunology
  • [ISO-abbreviation] Mol. Immunol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-chloro-5-nitrobenzanilide; 0 / Anilides; 0 / Eye Proteins; 0 / Nerve Growth Factors; 0 / PPAR gamma; 0 / Serpins; 0 / Tumor Suppressor Protein p53; 0 / pigment epithelium-derived factor; 9007-43-6 / Cytochromes c; EC 3.4.22.- / Caspase 9
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12. Sumbayev VV: LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein. FEBS Lett; 2008 Jan 23;582(2):319-26
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  • Here, we report that LPS-induced TLR4 signalling triggers cross talk of HIF-1alpha and ASK1 in THP-1 human myeloid monocytic leukaemia cells.

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  • (PMID = 18155167.001).
  • [ISSN] 0014-5793
  • [Journal-full-title] FEBS letters
  • [ISO-abbreviation] FEBS Lett.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA Primers; 0 / HIF1A protein, human; 0 / Hypoxia-Inducible Factor 1, alpha Subunit; 0 / Lipopolysaccharides; 0 / RNA, Messenger; 0 / Reactive Oxygen Species; 0 / Toll-Like Receptor 4; EC 2.7.11.25 / MAP Kinase Kinase Kinase 5
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13. Amtmann E, Zöller M: Stimulation of CD95-induced apoptosis in T-cells by a subtype specific neutral sphingomyelinase inhibitor. Biochem Pharmacol; 2005 Apr 15;69(8):1141-8
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  • In contrast, T-cells (human T-cell lymphoma and PHA stimulated murine lymph node cells) and monocytic leukemia cells were lacking SMase activity at pH 8.0.

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  • (PMID = 15794934.001).
  • [ISSN] 0006-2952
  • [Journal-full-title] Biochemical pharmacology
  • [ISO-abbreviation] Biochem. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD95; 0 / C11AG compound; 0 / Cell Extracts; 0 / Guanidines; 0 / Phytohemagglutinins; EC 3.1.4.12 / Sphingomyelin Phosphodiesterase
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14. Ashikaga T, Sakaguchi H, Sono S, Kosaka N, Ishikawa M, Nukada Y, Miyazawa M, Ito Y, Nishiyama N, Itagaki H: A comparative evaluation of in vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA). Altern Lab Anim; 2010 Aug;38(4):275-84
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  • We previously developed the human cell-line activation test (h-CLAT) in vitro skin sensitisation test, based on our reported finding that a 24-hour exposure of THP-1 cells (a human monocytic leukaemia cell line) to sensitisers is sufficient to induce the augmented expression of CD86 and CD54.
  • One hundred chemicals were selected, according to their categorisation in the local lymph node assay (LLNA), as being: extreme, strong, moderate and weak sensitisers, and non-sensitisers.
  • The h-CLAT could positively predict not only extreme and strong sensitisers, but also moderate and weak sensitisers, though the detection rates of weak sensitisers and non-sensitisers were comparatively low.

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  • [Copyright] 2010 FRAME.
  • (PMID = 20822320.001).
  • [ISSN] 0261-1929
  • [Journal-full-title] Alternatives to laboratory animals : ATLA
  • [ISO-abbreviation] Altern Lab Anim
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Organic Chemicals
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15. Bloise E, Braca A, De Tommasi N, Belisario MA: Pro-apoptotic and cytostatic activity of naturally occurring cardenolides. Cancer Chemother Pharmacol; 2009 Sep;64(4):793-802
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  • METHODS: The pro-apoptotic and cytostatic effect of the compounds was tested in U937 (monocytic leukemia) and PC3 (prostate adenocarcinoma).
  • Interestingly, periplocymarin, at cytostatic but non-cytotoxic doses, was shown to sensitize U937 cells to TRAIL.
  • CONCLUSIONS: Taken together, our data outline that cardiac glycosides are promising anticancer drugs and contribute to the identification of new natural cardiac glycosides to obtain chemically modified non-cardioactive/low toxic derivatives with enhanced anticancer potency.

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  • (PMID = 19184018.001).
  • [ISSN] 1432-0843
  • [Journal-full-title] Cancer chemotherapy and pharmacology
  • [ISO-abbreviation] Cancer Chemother. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cardenolides; 0 / DNA Primers; 0 / Enzyme Inhibitors; EC 3.6.3.9 / Sodium-Potassium-Exchanging ATPase
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16. Lindner D, Raghavan D: Intra-tumoural extra-cellular pH: a useful parameter of response to chemotherapy in syngeneic tumour lines. Br J Cancer; 2009 Apr 21;100(8):1287-91
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  • Doxorubicin-sensitive and doxorubicin-resistant sublines of P388 murine monocytic leukaemia in C57BL/6 mice were treated with increasing concentrations of doxorubicin.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor / analysis. Hydrogen-Ion Concentration. Leukemia P388 / drug therapy

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  • (PMID = 19367285.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide
  • [Other-IDs] NLM/ PMC2676543
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17. Chen L, Rodgers TR, Chaffins ML, Maeda K: Acute monocytic leukemia with cutaneous manifestation. Arch Pathol Lab Med; 2005 Mar;129(3):425-6
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  • [Title] Acute monocytic leukemia with cutaneous manifestation.
  • [MeSH-major] Leukemia, Monocytic, Acute / pathology. Skin Neoplasms / pathology

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  • (PMID = 15737049.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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18. Chen S, Xue Y, Zhang X, Wu Y, Pan J, Wang Y, Ceng J: A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice. Haematologica; 2005 Jun;90(6):766-75
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  • [Title] A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice.
  • BACKGROUND AND OBJECTIVES: Human leukemia cell lines are of great value in leukemia research.
  • Thus far 36 leukemia cell lines carrying the 11q23 translocation and MLL rearrangements, including two cell lines with t(6;11)(q27;q23) and an MLL-AF6 fusion gene have been described.
  • We have established a new monocytic cell line with t(6;11), designated SHI-1, and herein describe its biological characteristics.
  • DESIGN AND METHODS: Mononuclear cells isolated from the bone marrow of a patient with acute monocytic leukemia (AML-M5b) at relapse were inoculated and passaged by liquid culture.
  • The morphology and immunoprofile of the cells show typical features of monocytic lineage.
  • Karyotypic analysis demonstrated a t(6;11)(q27;q23) translocation accompanied by a deletion of 17p, which are the same abnormalities as were seen in the leukemia cells of this patient in relapse.
  • The MLL-AF6 fusion transcript and the loss of one p53 allele were proven by chromosome painting, FISH and RT-PCR analysis in both SHI-1 cells and the primary leukemia cells.
  • A point mutation of ATC-->ACC at codon 195 of exon 6 in another p53 allele was found by direct sequencing of DNA in SHI-1 cells as well as in the primary leukemia cells.
  • INTERPRETATION AND CONCLUSIONS: SHI-1 is a new monocytic leukemia cell line with the t(6;11) translocation, p53 gene alterations, and high tumorigenicity in nude mice.
  • [MeSH-major] Cell Line, Tumor. Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 6. Genes, p53. Leukemia, Monocytic, Acute / genetics. Translocation, Genetic


19. Ichiyama T, Hasegawa M, Ueno Y, Makata H, Matsubara T, Furukawa S: Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. Clin Exp Allergy; 2005 Sep;35(9):1214-9
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  • METHODS: We examined the production of TNF-alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, monocyte chemoattractant protein 1 (MCP-1), macrophage colony-stimulating factor (M-CSF), and eotaxin induced by CysLTs (leukotriene (LT)C4, -D4, and -E4) in THP-1 cells, a human monocytic leukaemia cell line, and peripheral blood CD14+ monocytes/macrophages.

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  • (PMID = 16164450.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD14; 0 / CCL11 protein, human; 0 / CCL2 protein, human; 0 / CCR2 protein, human; 0 / Chemokine CCL11; 0 / Chemokine CCL2; 0 / Chemokines, CC; 0 / Chromones; 0 / Cytokines; 0 / Leukotriene Antagonists; 0 / Leukotrienes; 0 / RNA, Messenger; 0 / Receptors, CCR2; 0 / Receptors, Chemokine; 0 / Tumor Necrosis Factor-alpha; 0 / pranlukast; 2CU6TT9V48 / Leukotriene C4; 73836-78-9 / Leukotriene D4; 75715-89-8 / Leukotriene E4; 81627-83-0 / Macrophage Colony-Stimulating Factor
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20. Brookhart MA, Rothman KJ: Simple estimators of the intensity of seasonal occurrence. BMC Med Res Methodol; 2008 Oct 22;8:67
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  • METHODS: We discuss various approaches to the estimation of seasonal intensity assuming Edwards's periodic model, including maximum likelihood estimation (MLE), least squares, weighted least squares, and a new closed-form estimator based on a second-order moment statistic and non-transformed data.
  • Finally, all estimators and confidence interval procedures discussed are compared in a re-analysis of data on the seasonality of monocytic leukemia.

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  • (PMID = 18945366.001).
  • [ISSN] 1471-2288
  • [Journal-full-title] BMC medical research methodology
  • [ISO-abbreviation] BMC Med Res Methodol
  • [Language] ENG
  • [Grant] United States / NIA NIH HHS / AG / K25 AG027400; United States / NIA NIH HHS / AG / AG-027400
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2596789
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21. Li ZJ, Chen ZX, Lu J, Cen JN, He J, Guo LC: [Growth and infiltration of human monocytic leukemia cell in nude mice: a model for central nervous system leukemia]. Zhonghua Xue Ye Xue Za Zhi; 2006 Jun;27(6):374-8
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  • [Title] [Growth and infiltration of human monocytic leukemia cell in nude mice: a model for central nervous system leukemia].
  • OBJECTIVE: To establish a model of human monocytic leukemia with CNS infiltration in BALB/c nude mice.
  • METHODS: BALB/c nu/nu mice pre-treated by splenectomy, cytoxan intraperitoneal injection, and sublethal irradiation (SCI), were transplanted intravenously with 1 x 10(7) of human monocytic leukemic SHI-1 cells.
  • In brain leukemia cells were filled in the subdural space and pia-arachnoid, covered the surface of cerebrum, cerebellum, spread along the virchow-robin space on the surface of pia mater, and eventually invaded the brain parenchyma.
  • CONCLUSION: SHI-1 cells could engrafted in the SCI-nu/nu mice, form an efficient and reproducible experimental model of CNSL and systematic leukemia.
  • [MeSH-major] Central Nervous System Neoplasms. Leukemia, Experimental. Leukemia, Monocytic, Acute

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  • (PMID = 17147225.001).
  • [ISSN] 0253-2727
  • [Journal-full-title] Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
  • [ISO-abbreviation] Zhonghua Xue Ye Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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22. Hunter AJ, Hendrikse AS, Renan MJ: Can radiation-induced apoptosis be modulated by inhibitors of energy metabolism? Int J Radiat Biol; 2007 Feb;83(2):105-14
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  • MATERIALS AND METHODS: Radiation-induced apoptosis was determined in U937 monocytic leukaemia cells exposed to energy inhibitors post-irradiation.
  • Respiration was measured using a Clark-type oxygen electrode.

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  • (PMID = 17357432.001).
  • [ISSN] 0955-3002
  • [Journal-full-title] International journal of radiation biology
  • [ISO-abbreviation] Int. J. Radiat. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 33X04XA5AT / Lactic Acid; 8L70Q75FXE / Adenosine Triphosphate; 968JJ8C9DV / Sodium Azide; 9G2MP84A8W / Deoxyglucose; EC 1.13.12.- / Luciferases; IY9XDZ35W2 / Glucose
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23. Tian L, Liu LB, Wang XB, Xiao J, Zou P: Impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2005 Jun;13(3):364-8
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  • [Title] Impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia.
  • To evaluate the impact of trisomy 8 on cytobiological and clinical features of acute myelomonocytic and monocytic leukemia (M(4), M(5)), a total of 56 cases of acute myelomonocytic and monocytic leukemia were investigated.
  • It is concluded that trisomy 8 may play an important role in the pathogenesis and progression of acute myelomonocytic/monocytic leukemia (M(4)/M(5)), whic seems to be related with a block in differentiation of monocytes.

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  • (PMID = 15972121.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / HLA-DR Antigens; EC 3.4.11.2 / Antigens, CD13
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24. Scrideli CA, Baruffi MR, Squire JA, Ramos ES, Karaskova J, Heck B, Tone LG: Acute monocytic leukemia and multiple abnormalities in a child with duplication of 1q detected by GTG-banding and SKY. Leuk Res; 2005 Dec;29(12):1465-7
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  • [Title] Acute monocytic leukemia and multiple abnormalities in a child with duplication of 1q detected by GTG-banding and SKY.
  • We describe a case of partial trisomy 1q "syndrome" and acute monocytic leukemia.
  • [MeSH-major] Abnormalities, Multiple / genetics. Chromosomes, Human, Pair 1. Leukemia, Monocytic, Acute / genetics. Trisomy

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  • (PMID = 15964069.001).
  • [ISSN] 0145-2126
  • [Journal-full-title] Leukemia research
  • [ISO-abbreviation] Leuk. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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25. Ichiyama T, Hasegawa M, Hashimoto K, Matsushige T, Hirano R, Furukawa S: Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages. Int Arch Allergy Immunol; 2009;148(2):147-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: We examined MIP-1alpha and MIP-1beta production stimulated by CysLTs (LTC(4), LTD(4), and LTE(4)) in THP-1 cells, a human monocytic leukemia cell line, and peripheral blood mononuclear cells (PBMCs).


26. Garcia C, Gardner D, Reichard KK: CD163: a specific immunohistochemical marker for acute myeloid leukemia with monocytic differentiation. Appl Immunohistochem Mol Morphol; 2008 Oct;16(5):417-21
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  • [Title] CD163: a specific immunohistochemical marker for acute myeloid leukemia with monocytic differentiation.
  • Acute myeloid leukemias (AMLs) with monocytic differentiation with or without recurring cytogenetic abnormalities have prognostic significance.
  • Monocytic differentiation is identified by morphology and confirmed by cytochemical stains or flow cytometry.
  • Thus, the utility of CD163, a hemoglobin scavenger molecule present on monocytes/macrophages, in identifying a monocytic component in AML in fixed, paraffin-embedded bone marrows was assessed.
  • Using tissue microarrays, 31 cases of AML with monocytic differentiation and 35 cases without monocytic differentiation were evaluated in a blinded fashion for CD163 positivity and compared with CD68.
  • CD163 immunoreactivity was seen in 49% of AML cases with and 6% (2/35) without monocytic differentiation.
  • CD68 was positive in 81% of AML cases with and 17% without monocytic differentiation.
  • CD163 showed superior specificity for a monocytic component in AML compared with CD68 (94% vs. 83%).
  • However, the suboptimal sensitivity (49%) limits its utility as a definitive marker of monocytic differentiation if negative in paraffin sections.
  • These findings demonstrate that CD163 is helpful for the evaluation of a monocytic component in AML.
  • When positive, correlation and evaluation for an associated recurring cytogenetic abnormality is warranted.

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  • (PMID = 18542032.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / Biomarkers, Tumor; 0 / CD163 antigen; 0 / CD68 antigen, human; 0 / Receptors, Cell Surface
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27. Liu LB, Li L, Xiao J, Zou P: Comparison of immunophenotype and clinical manifestations between patients with M5a and M5b of acute monocytic leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2006 Dec;14(6):1079-82
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  • [Title] Comparison of immunophenotype and clinical manifestations between patients with M5a and M5b of acute monocytic leukemia.
  • Acute monocytic leukemia is a distinct subtype of acute myeloid leukemia (AML) with characteristic biology and clinical features.
  • The results showed that the immunophenotypes of monocytic leukemic cells in patients with AML M(5) were heterogeneous, and CD68 and CD11b were expressed higher in patients with AML M(5a), compared with that in patients with AML M(5b) (P < 0.01).

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  • (PMID = 17204168.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD11b; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human
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28. Guo C, Inghirami G, Ibrahim S, Sen F: Epistaxis and severe weakness in a patient with multiple myeloma. Therapy-related acute myeloid leukemia, pure erythroid leukemia. Arch Pathol Lab Med; 2006 Jul;130(7):1075-6
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  • [Title] Epistaxis and severe weakness in a patient with multiple myeloma. Therapy-related acute myeloid leukemia, pure erythroid leukemia.
  • Therapy-related acute myeloid leukemias arise as a result of cytotoxic chemotherapy and/or radiation therapy.
  • The most common types of acute myeloid leukemia arising in this setting are acute myeloid leukemia with maturation, and lesser numbers of acute myelomonocytic leukemia, acute monocytic leukemia, acute erythroleukemia, or acute megakaryocytic leukemia.
  • We present a patient with multiple myeloma who was treated with melphalan and 4 years later developed acute erythroid leukemia.
  • The morphologic diagnosis of pure erythroid leukemia developing in the setting of multiple myeloma may be challenging.
  • [MeSH-major] Epistaxis / complications. Leukemia, Erythroblastic, Acute / complications. Multiple Myeloma / complications. Muscle Weakness / complications
  • [MeSH-minor] Acute Disease. Aged, 80 and over. Antineoplastic Agents, Alkylating / adverse effects. Humans. Leukemia, Myeloid. Male. Melphalan / adverse effects

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  • (PMID = 16831041.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; Q41OR9510P / Melphalan
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29. Yang XJ, Ullah M: MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells. Oncogene; 2007 Aug 13;26(37):5408-19
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  • Genes of the human monocytic leukemia zinc-finger protein MOZ (HUGO symbol, MYST3) and its paralog MORF (MYST4) are rearranged in chromosome translocations associated with acute myeloid leukemia and/or benign uterine leiomyomata.
  • Although leukemia-derived fusion proteins such as MOZ-TIF2 promote self-renewal of leukemic stem cells, recent studies indicate that murine MOZ and MORF are important for proper development of hematopoietic and neurogenic progenitors, respectively, thereby highlighting the importance of epigenetic integrity in safeguarding stem cell identity.

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  • (PMID = 17694082.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Protein Subunits; 0 / Trans-Activators; EC 2.3.1.48 / Histone Acetyltransferases; EC 2.3.1.48 / KAT6A protein, human; EC 2.3.1.48 / KAT6B protein, human
  • [Number-of-references] 106
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30. Aires V, Hichami A, Filomenko R, Plé A, Rébé C, Bettaieb A, Khan NA: Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells. Mol Pharmacol; 2007 Dec;72(6):1545-56
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  • We investigated, in monocytic leukemia U937 cells, the effects of docosahexaenoic acid (DHA; 22:6 n-3) on calcium signaling and determined the implication of phospholipase C (PLC) and protein kinase C (PKC) in this pathway.

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  • (PMID = 17878267.001).
  • [ISSN] 1521-0111
  • [Journal-full-title] Molecular pharmacology
  • [ISO-abbreviation] Mol. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Phosphatidylserines; 25167-62-8 / Docosahexaenoic Acids; 85166-31-0 / Inositol 1,4,5-Trisphosphate; EC 2.7.1.- / protein kinase C gamma; EC 2.7.11.13 / Protein Kinase C; EC 2.7.11.13 / Protein Kinase C-delta
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31. Li ZJ, Chen ZX, Cen JN, Lu J, He J: [Establishment of a nude mouse model of human monocytic leukemia with multi-organ infiltration]. Ai Zheng; 2006 Oct;25(10):1307-10
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  • [Title] [Establishment of a nude mouse model of human monocytic leukemia with multi-organ infiltration].
  • BACKGROUND & OBJECTIVE: Acute leukemia is always accompanied by extramedullary infiltration, which may be the source of relapse.
  • METHODS: After being treated by splenectomy, cytoxan intraperitoneal injection, and sublethal irradiation, 4-and 6-week old BALB/c nu/nu mice were transplanted intravenously with 5x10(6) or 1x10(7) of SHI-1 human monocytic leukemic cells.
  • [MeSH-major] Disease Models, Animal. Leukemia, Monocytic, Acute / pathology. Leukemic Infiltration / pathology

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  • (PMID = 17059783.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] EC 3.1.3.48 / Antigens, CD45
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32. Miranda CL, Reed RL, Kuiper HC, Alber S, Stevens JF: Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. Chem Res Toxicol; 2009 May;22(5):863-74
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  • [Title] Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells.
  • The effects of intracellular ascorbic acid (vitamin C) on HNE-induced cytotoxicity and protein carbonylation were investigated in human THP-1 monocytic leukemia cells.

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  • (PMID = 19326901.001).
  • [ISSN] 1520-5010
  • [Journal-full-title] Chemical research in toxicology
  • [ISO-abbreviation] Chem. Res. Toxicol.
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / S10 RR022589; United States / NHLBI NIH HHS / HL / R01 HL081721-03; United States / NCRR NIH HHS / RR / RR022589-01; United States / NIEHS NIH HHS / ES / P30ES000210; United States / NCRR NIH HHS / RR / S10 RR022589-01; United States / NCRR NIH HHS / RR / S10RR022589; United States / NHLBI NIH HHS / HL / R01 HL081721; United States / NHLBI NIH HHS / HL / HL081721-03; United States / NIEHS NIH HHS / ES / P30 ES000210-40; United States / NHLBI NIH HHS / HL / R01HL081721; United States / NIEHS NIH HHS / ES / P30 ES000210
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Aldehydes; 0 / Fluoresceins; 111843-78-8 / 5(6)-carboxy-2',7'-dichlorofluorescein; 29343-52-0 / 4-hydroxy-2-nonenal; EC 3.4.22.- / Caspase 3; GAN16C9B8O / Glutathione; PQ6CK8PD0R / Ascorbic Acid
  • [Other-IDs] NLM/ NIHMS106305; NLM/ PMC2730585
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33. Thomas T, Corcoran LM, Gugasyan R, Dixon MP, Brodnicki T, Nutt SL, Metcalf D, Voss AK: Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev; 2006 May 1;20(9):1175-86
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  • [Title] Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells.
  • Monocytic leukemia zinc finger protein (MOZ), a transcriptional coactivator and member of the MYST family of histone acetyltransferases, is the target of recurrent translocations in acute myeloid leukemia.
  • Since genes associated with translocations in leukemia are typically important regulators of blood formation, we investigated if Moz has a role in normal hematopoiesis.


34. Nakamura H, Dan S, Akashi T, Unno M, Yamori T: Absolute quantification of four isoforms of the class I phosphoinositide-3-kinase catalytic subunit by real-time RT-PCR. Biol Pharm Bull; 2007 Jun;30(6):1181-4
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  • Using this system, we investigated human monocytic leukemia cells (U937) to analyze expression of all four isoforms.

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  • (PMID = 17541179.001).
  • [ISSN] 0918-6158
  • [Journal-full-title] Biological & pharmaceutical bulletin
  • [ISO-abbreviation] Biol. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Comparative Study; Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Isoenzymes; EC 2.7.1.- / Phosphatidylinositol 3-Kinases
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35. Sevastyanova O, Binkova B, Topinka J, Sram RJ, Kalina I, Popov T, Novakova Z, Farmer PB: In vitro genotoxicity of PAH mixtures and organic extract from urban air particles part II: human cell lines. Mutat Res; 2007 Jul 1;620(1-2):123-34
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  • Metabolically competent human hepatoma HepG2 cells, confluent cultures of human diploid lung fibroblasts (HEL), and the human monocytic leukemia cell line THP-1 were used as models.

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  • (PMID = 17420030.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Air Pollutants; 0 / Carcinogens, Environmental; 0 / DNA Adducts; 0 / Organic Chemicals; 0 / Particulate Matter; 0 / Polycyclic Hydrocarbons, Aromatic
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36. Kuo CC, Kuo CW, Liang CM, Liang SM: A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells. Proteomics; 2005 Mar;5(4):894-906
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  • [Title] A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells.
  • [MeSH-major] CpG Islands. Gene Expression Regulation, Neoplastic. Genetic Therapy / methods. Leukemia, Monocytic, Acute / therapy. Oligonucleotides / genetics. Proteomics / methods. Transcription, Genetic

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  • (PMID = 15693060.001).
  • [ISSN] 1615-9853
  • [Journal-full-title] Proteomics
  • [ISO-abbreviation] Proteomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Oligonucleotides; 0 / RNA, Messenger; 20350-15-6 / Brefeldin A; EC 1.13.12.- / Luciferases; EC 3.4.21.4 / Trypsin
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37. Yamamoto K, Okamura A, Kawano H, Katayama Y, Shimoyama M, Matsui T: A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. Cancer Genet Cytogenet; 2007 Jul 15;176(2):144-9
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  • [Title] A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism.
  • We describe the case of a 38-year-old woman with a normal phenotype who developed to acute monocytic leukemia with a novel t(8;18)(q13;q21).
  • FISH also revealed that trisomy 8 was detected in buccal mucosa cells, indicating that trisomy 8 was a constitutional abnormality.
  • These results suggest that t(8;18)(q13;q21) had a crucial role in the development of leukemia as the second mutation following CT8M.
  • [MeSH-major] Chromosomes, Human, Pair 18. Chromosomes, Human, Pair 8. Leukemia, Monocytic, Acute / genetics. Mosaicism. Translocation, Genetic. Trisomy / genetics

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  • (PMID = 17656258.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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38. Troke PJ, Kindle KB, Collins HM, Heery DM: MOZ fusion proteins in acute myeloid leukaemia. Biochem Soc Symp; 2006;(73):23-39
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  • [Title] MOZ fusion proteins in acute myeloid leukaemia.
  • MOZ (monocytic leukaemia zinc finger protein; also known as ZNF220 or MYST3) is a member of the MYST family of protein acetyltransferases.
  • Chromosomal translocations involving the MOZ gene are associated with AML (acute myeloid leukaemia), suggesting that it has a role in haematopoiesis.
  • [MeSH-major] Histone Acetyltransferases / metabolism. Leukemia, Myeloid, Acute / etiology. Oncogene Proteins, Fusion / metabolism

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  • (PMID = 16626284.001).
  • [ISSN] 0067-8694
  • [Journal-full-title] Biochemical Society symposium
  • [ISO-abbreviation] Biochem. Soc. Symp.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CREBBP protein, human; 0 / NCOA2 protein, human; 0 / Nuclear Receptor Coactivator 2; 0 / Oncogene Proteins, Fusion; 0 / Trans-Activators; EC 2.3.1.48 / CREB-Binding Protein; EC 2.3.1.48 / Histone Acetyltransferases; EC 2.3.1.48 / KAT6A protein, human
  • [Number-of-references] 67
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39. Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR: Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia; 2010 May;24(5):1077-80
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  • [Title] Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN.
  • [MeSH-major] Disease Models, Animal. Integrases / metabolism. Leukemia, Monocytic, Acute / pathology. Myeloid Cells / pathology. PTEN Phosphohydrolase / physiology

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  • (PMID = 20220776.001).
  • [ISSN] 1476-5551
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / P01 DK080665; United States / NHLBI NIH HHS / HL / R01 HL092437
  • [Publication-type] Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Reactive Oxygen Species; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt; EC 2.7.7.- / Cre recombinase; EC 2.7.7.- / Integrases; EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ NIHMS586913; NLM/ PMC4134872
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40. Huang JR, Wu CC, Hou RC, Jeng KC: Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14. Immunol Invest; 2008;37(4):263-77
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  • Therefore, we investigated the effect of bromelain on cytokine production from lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMC) and monocytic leukemia THP-1 cells.

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  • (PMID = 18569070.001).
  • [ISSN] 1532-4311
  • [Journal-full-title] Immunological investigations
  • [ISO-abbreviation] Immunol. Invest.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD14; 0 / Cytokines; 0 / Interleukin-1; 0 / Interleukin-6; 0 / Lipopolysaccharides; 0 / NF-kappa B; 0 / Tumor Necrosis Factor-alpha; 9001-00-7 / Bromelains; EC 1.14.99.1 / Cyclooxygenase 2; K7Q1JQR04M / Dinoprostone
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41. Ichiyama T, Kajimoto M, Hasegawa M, Hashimoto K, Matsubara T, Furukawa S: Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix metalloproteinase-9 in human monocytes/macrophages. Clin Exp Allergy; 2007 Apr;37(4):608-14
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  • METHODS: We examined the effect of cysLTs (LTC4, -D4 and -E4) on TNF-alpha-induced MMP-9 production in THP-1 cells, a human monocytic leukaemia cell line and peripheral blood CD14+ monocytes/macrophages.

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  • (PMID = 17430359.001).
  • [ISSN] 0954-7894
  • [Journal-full-title] Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • [ISO-abbreviation] Clin. Exp. Allergy
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Asthmatic Agents; 0 / Chromones; 0 / Leukotriene Antagonists; 0 / Leukotrienes; 0 / Membrane Proteins; 0 / RNA, Messenger; 0 / Receptors, Leukotriene; 0 / Tumor Necrosis Factor-alpha; 0 / cysteinyl-leukotriene; 0 / leukotriene D4 receptor; 0 / pranlukast; EC 3.4.24.35 / Matrix Metalloproteinase 9; K848JZ4886 / Cysteine
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42. Liu LB, Li L, Zou P: Comparison of cytogenetics and clinical manifestations between M5a and M5b of acute monocytic leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2006 Aug;14(4):654-7
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  • [Title] Comparison of cytogenetics and clinical manifestations between M5a and M5b of acute monocytic leukemia.
  • To compare the cytogenetic difference between M5a and M5b of acute monocytic leukemia and to study the correlation between karyotypes and clinical manifestations, a total of 58 cases of de novo adult AML M5 have been investigated.
  • It is concluded that acute monocytic leukemia is a series of heterogeneous diseases, a distinctive cytogenetic features can be observed between patients with AML M5a and M5b, these results will provide insights into the classification and pathogenesis mechanism of AML M5 at molecular level.

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  • (PMID = 16928293.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] ENG
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] China
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43. Johnson ES, Ndetan H, Lo KM: Cancer mortality in poultry slaughtering/processing plant workers belonging to a union pension fund. Environ Res; 2010 Aug;110(6):588-94
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  • RESULTS: Significantly increased risks were observed in the cohort as a whole or in subgroups, for several cancer sites, viz: cancers of the buccal cavity and pharynx; pancreas; trachea/bronchus/lung; brain; cervix; lymphoid leukemia; monocytic leukemia; and tumors of the hemopoietic and lymphatic systems.
  • What is needed now are epidemiologic studies that can demonstrate whether the excess of specific cancers can be attributed to specific occupational exposures while adequately controlling for other potential occupational and non-occupational carcinogenic exposures.

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • [ErratumIn] Environ Res. 2011 Jan;111(1):188-90
  • (PMID = 20541185.001).
  • [ISSN] 1096-0953
  • [Journal-full-title] Environmental research
  • [ISO-abbreviation] Environ. Res.
  • [Language] eng
  • [Grant] United States / NIOSH CDC HHS / OH / 1R01OH008071; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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44. Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong CH, Juan HF: Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction. BMC Genomics; 2007;8:411
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  • [Title] Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction.
  • This gave rise to our investigation on how F3 stimulates immuno-modulating or anti-tumor effects in human leukemia THP-1 cells.
  • [MeSH-minor] Blotting, Western. Cell Line, Tumor. Cytokines / genetics. Cytokines / metabolism. Enzyme-Linked Immunosorbent Assay. Gene Expression Profiling. Humans. Leukemia, Monocytic, Acute / genetics. Leukemia, Monocytic, Acute / metabolism. Leukemia, Monocytic, Acute / pathology. Oligonucleotide Array Sequence Analysis. Plant Extracts / chemistry. Plant Extracts / pharmacology. Polymerase Chain Reaction. Receptors, Death Domain / genetics. Receptors, Death Domain / metabolism. Signal Transduction / drug effects. Signal Transduction / genetics. Signal Transduction / physiology

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  • (PMID = 17996095.001).
  • [ISSN] 1471-2164
  • [Journal-full-title] BMC genomics
  • [ISO-abbreviation] BMC Genomics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cytokines; 0 / Drugs, Chinese Herbal; 0 / Plant Extracts; 0 / Polysaccharides; 0 / Receptors, Death Domain
  • [Other-IDs] NLM/ PMC2211495
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45. Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T: LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). Eur J Haematol; 2007 Jul;79(1):25-31
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  • [Title] LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).
  • OBJECTIVE: The RUNX1 (also known as AML1) gene is observed frequently as the target of chromosomal rearrangements in human acute leukemia.
  • We describe here a previously unreported rearrangement, t(11;21)(q13;q22), that disrupts the RUNX1 gene in a patient with acute leukemia and the molecular analysis of the fusion gene.
  • METHODS: We have established a monocytic leukemia cell line, ELAM-1, from a patient with acute leukemia evolving from myelodysplastic syndrome (MDS).
  • Translocation (11;21) (q13;q22) was observed in both patient leukemia cells and ELAM-1.
  • Although it was reported that overexpression of LRP16 promotes human breast cancer cell proliferation, the function of LRP16 in leukemia remains to be studied.
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 21. Core Binding Factor Alpha 2 Subunit / genetics. Leukemia, Monocytic, Acute / genetics. Neoplasm Proteins / genetics. Translocation, Genetic

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  • (PMID = 17532767.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Core Binding Factor Alpha 2 Subunit; 0 / DNA Primers; 0 / LRP16 protein, human; 0 / Neoplasm Proteins; 0 / RUNX1 protein, human
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46. Hashimoto K, Ichiyama T, Hasegawa M, Hasegawa S, Matsubara T, Furukawa S: Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. Int Arch Allergy Immunol; 2009;149(3):275-82
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  • METHODS: The activation of mitogen-activated protein kinase (MAPK), including extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK) and p38 MAPK by phosphorylation, and nuclear factor-kappaB (NF-kappaB) by leukotriene (LT) D(4) and LTC(4) was determined in THP-1 cells, a human monocytic leukemia cell line, and peripheral blood CD14+ monocytes/macrophages.


47. Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Côté J, Yang XJ: Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol; 2008 Nov;28(22):6828-43
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  • The monocytic leukemia zinc finger protein MOZ and the related factor MORF form tetrameric complexes with ING5 (inhibitor of growth 5), EAF6 (Esa1-associated factor 6 ortholog), and the bromodomain-PHD finger protein BRPF1, -2, or -3.

  • Gene Ontology. gene/protein/disease-specific - Gene Ontology annotations from this paper .
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  • (PMID = 18794358.001).
  • [ISSN] 1098-5549
  • [Journal-full-title] Molecular and cellular biology
  • [ISO-abbreviation] Mol. Cell. Biol.
  • [Language] ENG
  • [Grant] None / None / / 64289-2; None / None / / 87253-1; Canada / Canadian Institutes of Health Research / / 64289-2; Canada / Canadian Institutes of Health Research / / 87253-1
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / BRPF1 protein, human; 0 / ING5 protein, human; 0 / Multiprotein Complexes; 0 / Nuclear Proteins; 0 / Protein Subunits; 0 / Recombinant Fusion Proteins; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; EC 2.3.1.48 / Histone Acetyltransferases; EC 2.3.1.48 / KAT6A protein, human; EC 2.3.1.48 / KAT6B protein, human
  • [Other-IDs] NLM/ PMC2573306
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48. Sheng LX, Xie XB, Qiu GQ, Gu WY, Wang ZL, Wu HQ: [In vitro stimulation of specific antileukemia T-cell response by dendritic cells derived from CD14+ acute monocytic leukemia cells]. Ai Zheng; 2005 Nov;24(11):1338-44
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  • [Title] [In vitro stimulation of specific antileukemia T-cell response by dendritic cells derived from CD14+ acute monocytic leukemia cells].
  • BACKGROUND & OBJECTIVE: Dendritic cells (DCs) or DC-like cells had been successfully induced in vitro from leukemia cells, which may provide a promising immunotherapeutic protocol for leukemia.
  • This study was designed to investigate the efficiency of in vitro generation of dendritic cells from CD14+ acute myelomonocytic (M4) or monocytic (M5) leukemia cells and their ability of stimulating specific antileukemia T-cell response.
  • METHODS: Bone marrow mononuclear cells (BMMNCs) were isolated from 5 M4/M5 leukemia patients with high CD14 expression, and then divided into 3 groups: adherent leukemia cells, nonadherent blasts, and total unfractioned blasts.
  • When cultured with or without granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-4 (IL-4) and tumor necrosis factor alpha (TNF-alpha) for 7-10 days, monocytic leukemia cell-derived dendritic cells (Mo-LDCs) were identified through morphologic observation and immunophenotype analysis using FCM.
  • RESULTS: The amount of CD14+ cells, which could differentiate into CD83+ mature DCs under induction of the cytokine combination, was higher in adherent leukemia cells than in nonadherent blasts and total unfractioned blasts.
  • Mo-LDCs exhibited typical morphology and phenotype as mature DCs, induced potent proliferation of homogeneous T cells in Allo-MLR, stimulated the expansion of leukemia-specific CTLs, and continued to possess the cytogenetic abnormalities of the original leukemia, as well as the aberrant expression of myeloid antigens.
  • CD14 expression level may predict the DCs differentiation ability of monocytic leukemia.
  • [MeSH-major] Antigens, CD14 / analysis. Dendritic Cells / immunology. Leukemia, Monocytic, Acute / pathology. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 16552959.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD14; 0 / CD83 antigen; 0 / Immunoglobulins; 0 / Membrane Glycoproteins
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49. Kivivuori SM, Siitonen S, Porkka K, Vettenranta K, Alitalo R, Saarinen-Pihkala U: Expression of vascular endothelial growth factor receptor 3 and Tie1 tyrosine kinase receptor on acute leukemia cells. Pediatr Blood Cancer; 2007 Apr;48(4):387-92
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  • [Title] Expression of vascular endothelial growth factor receptor 3 and Tie1 tyrosine kinase receptor on acute leukemia cells.
  • Activation of vascular endothelial growth factor receptor 3 (VEGFR-3) and Tie1 tyrosine kinase receptor are known to promote leukemia cell survival.
  • PROCEDURE: We studied bone marrow samples from 73 patients with acute lymphoblastic (ALL) or myelogenous (AML) leukemia by using immunological methods.
  • RESULTS: Vascular endothelial growth factor receptor 3 expression was found in 15% of the samples, particularly in samples with pediatric lymphoblastic leukemias and monocytic AMLs.
  • CONCLUSIONS: Our findings suggest that there are angiogenesis-related differences between pediatric and adult lymphoblastic leukemias as well as between lymphoid and myeloid leukemias.
  • [MeSH-major] Hematopoietic Stem Cells / enzymology. Leukemia, Myeloid / enzymology. Neoplastic Stem Cells / enzymology. Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / enzymology. Receptor, TIE-1 / analysis. Vascular Endothelial Growth Factor Receptor-3 / analysis
  • [MeSH-minor] Acute Disease. Adolescent. Adult. Age Factors. Antigens, CD / analysis. Antigens, CD34 / analysis. Bone Marrow / pathology. Child. Child, Preschool. Female. Glycoproteins / analysis. Humans. Immunophenotyping. Infant. Leukemia, Monocytic, Acute / enzymology. Leukemia, Monocytic, Acute / pathology. Male. Neovascularization, Pathologic / enzymology. Neovascularization, Pathologic / pathology. Peptides / analysis

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  • (PMID = 16685739.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / AC133 antigen; 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Glycoproteins; 0 / Peptides; EC 2.7.10.1 / Receptor, TIE-1; EC 2.7.10.1 / Vascular Endothelial Growth Factor Receptor-3
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50. Brecht M, Steenvoorden AC, Collard JG, Luf S, Erz D, Bartram CR, Janssen JW: Activation of gef-h1, a guanine nucleotide exchange factor for RhoA, by DNA transfection. Int J Cancer; 2005 Feb 10;113(4):533-40
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  • In a search for genes with oncogenic potential in DNA from the monocytic leukaemia cell line U937, we identified an amino-terminal truncated form of gef-h1, a gene encoding a GEF for RhoA.

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  • (PMID = 15455375.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / ARHGEF2 protein, human; 0 / Guanine Nucleotide Exchange Factors; 0 / Rho Guanine Nucleotide Exchange Factors; 9007-49-2 / DNA; EC 3.6.5.2 / rhoA GTP-Binding Protein
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51. Shirkoohi R: [Ability of actin-regulatory protein, gelsolin in induction of monocytic leukemia cell differentiation]. Hokkaido Igaku Zasshi; 2006 Mar;81(2):159-67
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  • [Title] [Ability of actin-regulatory protein, gelsolin in induction of monocytic leukemia cell differentiation].
  • [MeSH-major] Actins / physiology. Gelsolin / physiology. Leukemia, Monocytic, Acute / pathology

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  • (PMID = 16669119.001).
  • [ISSN] 0367-6102
  • [Journal-full-title] [Hokkaido igaku zasshi] The Hokkaido journal of medical science
  • [ISO-abbreviation] Hokkaido Igaku Zasshi
  • [Language] jpn
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Actins; 0 / Cyclin-Dependent Kinase Inhibitor Proteins; 0 / Gelsolin
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52. Tariku Y, Hymete A, Hailu A, Rohloff J: Essential-oil composition, antileishmanial, and toxicity study of Artemisia abyssinica and Satureja punctata ssp. punctata from Ethiopia. Chem Biodivers; 2010 Apr;7(4):1009-18
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  • Essential oils of Artemisia abyssinica and Satureja punctata ssp. punctata from Ethiopia were analyzed by GC and GC/MS, and screened for leishmanicidal activity against promastigote and axenic amastigotes of Leishmania donovani and L. aethiopica, including toxicity studies on human monocytic leukemia cells (THP-1) and erythrocytes in vitro.

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  • (PMID = 20397218.001).
  • [ISSN] 1612-1880
  • [Journal-full-title] Chemistry & biodiversity
  • [ISO-abbreviation] Chem. Biodivers.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antiprotozoal Agents; 0 / Oils, Volatile
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53. Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I: PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med; 2010 May;16(5):580-5, 1p following 585
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  • [Title] PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2.
  • Leukemias and other cancers possess self-renewing stem cells that help to maintain the cancer.
  • Using an acute myeloid leukemia (AML) model induced by the leukemia-associated monocytic leukemia zinc finger (MOZ)-TIF2 fusion protein, we show here that AML can be cured by the ablation of leukemia stem cells.
  • Cells expressing high amounts of CSF1R (CSF1R(high) cells), but not those expressing low amounts of CSF1R (CSF1R(low) cells), showed potent leukemia-initiating activity.
  • Moreover, induction of AML was suppressed in CSF1R-deficient mice and CSF1R inhibitors slowed the progression of MOZ-TIF2-induced leukemia.
  • Thus, in this subtype of AML, leukemia stem cells are contained within the CSF1R(high) cell population, and we suggest that targeting of PU.1-mediated upregulation of CSF1R expression might be a useful therapeutic approach.

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  • (PMID = 20418886.001).
  • [ISSN] 1546-170X
  • [Journal-full-title] Nature medicine
  • [ISO-abbreviation] Nat. Med.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA041456-24; United States / NCI NIH HHS / CA / R01 CA032551; United States / NCI NIH HHS / CA / P01 CA066996; United States / NCI NIH HHS / CA / 5P30-CA13330; United States / NCI NIH HHS / CA / CA041456-24; United States / NCI NIH HHS / CA / R01-CA41456; United States / NCI NIH HHS / CA / CA32551; United States / NCI NIH HHS / CA / R01 CA041456; United States / NCI NIH HHS / CA / P30 CA013330; United States / NHLBI NIH HHS / HL / R01 HL112719
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Colony-Stimulating Factors; 0 / NCOA2 protein, human; 0 / Nuclear Receptor Coactivator 2; 0 / Proto-Oncogene Proteins; 0 / Receptors, Colony-Stimulating Factor; 0 / Recombinant Fusion Proteins; 0 / Trans-Activators; 0 / proto-oncogene protein Spi-1; 81627-83-0 / Macrophage Colony-Stimulating Factor; EC 2.7.10.1 / Receptor, Macrophage Colony-Stimulating Factor
  • [Other-IDs] NLM/ NIHMS265702; NLM/ PMC3039870
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54. Ventura F, Pereira T, da Luz Duarte M, Marques H, Pardal F, Brito C: Indeterminate cell histiocytosis in association with acute myeloid leukemia. Dermatol Res Pract; 2010;2010:569345
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  • [Title] Indeterminate cell histiocytosis in association with acute myeloid leukemia.
  • Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder, in which the predominant cells share morphologic and immunophenotypic features from both Langerhans and non-Langerhans cell histiocytosis.
  • Nevertheless, one month after remission, he developed an acute myeloid leukemia of the subtype monocytic leukemia (M5).
  • We present this case because apart of being rare it joins the effectiveness of thalidomide and the association with an acute monocytic leukemia.

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  • (PMID = 20672000.001).
  • [ISSN] 1687-6113
  • [Journal-full-title] Dermatology research and practice
  • [ISO-abbreviation] Dermatol Res Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2905718
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55. Yoshikawa Y, Sasahara Y, Kitano Y, Kanazawa N, Shima H, Hashimoto-Tamaoki T: Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene ID2, by contact sensitizers in human bulge-derived keratinocytes. J Biochem Mol Toxicol; 2010 Jan-Feb;24(1):10-20
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  • In this study, we analyzed the molecular responses to certain contact sensitizers (2,4-dinitrochlorobenzene and NiSO(4)) and irritants (sodium dodecyl sulfate and benzalkonium chloride) in cultured human keratinocytes from the bulge region of a plucked hair follicle (bulge-derived keratinocytes [BDKs]) and compared these molecular responses to those with the human monocytic leukemia cell line, THP-1.

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  • (PMID = 20146380.001).
  • [ISSN] 1099-0461
  • [Journal-full-title] Journal of biochemical and molecular toxicology
  • [ISO-abbreviation] J. Biochem. Mol. Toxicol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / ID2 protein, human; 0 / Inhibitor of Differentiation Protein 2; 0 / Interleukins; 0 / Irritants; 0 / NF-E2-Related Factor 2; 0 / NFE2L2 protein, human
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56. Ge Y, Rikihisa Y: Surface-exposed proteins of Ehrlichia chaffeensis. Infect Immun; 2007 Aug;75(8):3833-41
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  • Nineteen out of 22 OMP-1/P28 family proteins, including P28 (which previously was shown to be surface exposed), were detected in E. chaffeensis cultured in human monocytic leukemia THP-1 cells.

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  • (PMID = 17517859.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI030010; United States / NIAID NIH HHS / AI / R01 AI 30010
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Outer Membrane Proteins; 0 / Bacterial Proteins; 0 / Membrane Proteins; 0 / Succinimides; 0 / sulfo-N-hydroxysuccinimide-biotin; 6SO6U10H04 / Biotin
  • [Other-IDs] NLM/ PMC1951975
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57. Kim JA, Kong CS, Kim SK: Effect of Sargassum thunbergii on ROS mediated oxidative damage and identification of polyunsaturated fatty acid components. Food Chem Toxicol; 2010 May;48(5):1243-9
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  • Treatment with S. thunbergii significantly reduced intracellular ROS mediated cell damage and inhibited myeloperoxidase (MPO) activity assessed in tumor necrosis factor-alpha (TNF-alpha) stimulated human monocytic leukemia in a concentration-dependent manner.
  • Furthermore, S. thunbergii contains polyunsaturated fatty acids such as arachidonic acid, arachidic acid, palmitic acid, elaidic acid, linoleic acid, stearic acid and cis-5,8,11,14,17-eicosanoic acid.

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20171254.001).
  • [ISSN] 1873-6351
  • [Journal-full-title] Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • [ISO-abbreviation] Food Chem. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Enzyme Inhibitors; 0 / Fatty Acids, Unsaturated; 0 / Fluoresceins; 0 / Oxidants; 0 / Plant Extracts; 0 / Reactive Oxygen Species; 2044-85-1 / diacetyldichlorofluorescein; BBX060AN9V / Hydrogen Peroxide; EC 1.- / Oxidoreductases; EC 1.11.1.7 / Peroxidase
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58. Wilson CS, Davidson GS, Martin SB, Andries E, Potter J, Harvey R, Ar K, Xu Y, Kopecky KJ, Ankerst DP, Gundacker H, Slovak ML, Mosquera-Caro M, Chen IM, Stirewalt DL, Murphy M, Schultz FA, Kang H, Wang X, Radich JP, Appelbaum FR, Atlas SR, Godwin J, Willman CL: Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood; 2006 Jul 15;108(2):685-96
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  • [Title] Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction.
  • To determine whether gene expression profiling could improve risk classification and outcome prediction in older acute myeloid leukemia (AML) patients, expression profiles were obtained in pretreatment leukemic samples from 170 patients whose median age was 65 years.
  • Cluster F (n = 33) was dominated by monocytic leukemias (97% of cases), also showing increased NPM1 mutations (61%).

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  • (PMID = 16597596.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA32102; United States / NCI NIH HHS / CA / CA88361
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Nuclear Proteins; 117896-08-9 / nucleophosmin
  • [Other-IDs] NLM/ PMC1895492
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59. Nomdedéu J, Carricondo MT, Lasa A, Perea G, Aventin A, Sierra J: Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients. Haematologica; 2005 Mar;90(3):412-3
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  • [Title] Low frequency of exon 3 PTPN11 mutations in adult de novo acute myeloid leukemia. Analysis of a consecutive series of 173 patients.
  • A total of 173 samples obtained from adult patients with de novo acute myeloid leukemia (AML) were assayed for exon 3 PTPN11 mutations by single strand conformation polymorphism (SSCP) analysis and direct sequencing.
  • Only three monocytic leukemias had point mutations (1.73%).
  • [MeSH-major] Intracellular Signaling Peptides and Proteins / genetics. Leukemia, Myeloid / genetics. Point Mutation. Protein Tyrosine Phosphatases / genetics
  • [MeSH-minor] Acute Disease. Adult. Cause of Death. Exons. Female. Gene Frequency. Humans. Male. Middle Aged. Protein Tyrosine Phosphatase, Non-Receptor Type 11. Spain

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  • (PMID = 15749679.001).
  • [ISSN] 1592-8721
  • [Journal-full-title] Haematologica
  • [ISO-abbreviation] Haematologica
  • [Language] eng
  • [Publication-type] Letter; Research Support, Non-U.S. Gov't
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Intracellular Signaling Peptides and Proteins; EC 3.1.3.48 / PTPN11 protein, human; EC 3.1.3.48 / Protein Tyrosine Phosphatase, Non-Receptor Type 11; EC 3.1.3.48 / Protein Tyrosine Phosphatases
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60. Tanaka T, Fukunaga Y, Itoh H, Doi K, Yamashita J, Chun TH, Inoue M, Masatsugu K, Saito T, Sawada N, Sakaguchi S, Arai H, Nakao K: Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. Eur J Pharmacol; 2005 Jan 31;508(1-3):255-65
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  • Troglitazone and pioglitazone, the two thiazolidinediones, as well as 15-deoxy-delta12,14-prostaglandin J2 inhibited in a dose-dependent manner the serum-induced proliferation of THP-1 (human monocytic leukemia cells) and of U937 (human monoblastic leukemia cells), which permanently express PPARgamma.

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  • (PMID = 15680279.001).
  • [ISSN] 0014-2999
  • [Journal-full-title] European journal of pharmacology
  • [ISO-abbreviation] Eur. J. Pharmacol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / 15-deoxy-delta(12,14)-prostaglandin J2; 0 / CCR2 protein, human; 0 / Chemokine CCL2; 0 / Chromans; 0 / PPAR gamma; 0 / RNA, Messenger; 0 / Receptors, CCR2; 0 / Receptors, Chemokine; 0 / Thiazolidinediones; 0 / Vascular Endothelial Growth Factor A; 5300-03-8 / alitretinoin; 5688UTC01R / Tretinoin; I66ZZ0ZN0E / troglitazone; RXY07S6CZ2 / Prostaglandin D2; X4OV71U42S / pioglitazone
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61. Nakamura T, Noguchi T, Miyachi H, Hashimoto Y: Hydrolyzed metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity. Chem Pharm Bull (Tokyo); 2007 Apr;55(4):651-4
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  • Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-alpha production in the human monocytic leukemia cell line THP-1 was evaluated.

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  • (PMID = 17409565.001).
  • [ISSN] 0009-2363
  • [Journal-full-title] Chemical & pharmaceutical bulletin
  • [ISO-abbreviation] Chem. Pharm. Bull.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Tumor Necrosis Factor-alpha; 4Z8R6ORS6L / Thalidomide
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62. Akan Z, Aksu B, Tulunay A, Bilsel S, Inhan-Garip A: Extremely low-frequency electromagnetic fields affect the immune response of monocyte-derived macrophages to pathogens. Bioelectromagnetics; 2010 Dec;31(8):603-12
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  • THP-1 cells (human monocytic leukemia cell line) were cultured and 50 Hz, 1 mT EMF was applied for 4-6 h to cells induced with Staphylococcus aureus or interferon gamma/lipopolysaccharide (IFγ/LPS).
  • [MeSH-minor] Apoptosis / immunology. Apoptosis / radiation effects. Caspase 9 / metabolism. Cell Differentiation. Cell Line, Tumor. Cyclic GMP / metabolism. Enzyme Activation / immunology. Enzyme Activation / radiation effects. HSP70 Heat-Shock Proteins / metabolism. Humans. Nitric Oxide / metabolism. Nitric Oxide Synthase Type II / metabolism

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  • [Copyright] Copyright © 2010 Wiley-Liss, Inc.
  • (PMID = 20809504.001).
  • [ISSN] 1521-186X
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / HSP70 Heat-Shock Proteins; 31C4KY9ESH / Nitric Oxide; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 3.4.22.- / Caspase 9; H2D2X058MU / Cyclic GMP
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63. Heidinger M, Kolb H, Krell HW, Jochum M, Ries C: Modulation of autocrine TNF-alpha-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells. Biol Chem; 2006 Jan;387(1):69-78
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  • [Title] Modulation of autocrine TNF-alpha-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells.
  • Here we show that constitutive MMP-9 secretion was abrogated in THP-1 monocytic leukemia cells by addition of neutralizing antibodies against tumor necrosis factor alpha (TNF-alpha) or TNF receptor type 1 (TNF-R1), as well as by inhibition of TNF-alpha converting enzyme (TACE).


64. Sindt A, Deau B, Brahim W, Staal A, Visanica S, Villarese P, Rault JP, Macintyre E, Delabesse E: Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9. Genes Chromosomes Cancer; 2006 Jun;45(6):575-82
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  • [Title] Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9.
  • The t(9;22)(q34;q11) translocation occurs in chronic myeloid leukemia (CML) and adult B-cell acute lymphoblastic leukemia (ALL), leading to fusion of BCR to ABL1 and constitutive activation of ABL1 tyrosine kinase activity.
  • We describe here the first case of t(9;22)(q34;q11) associated with t(10;11)(p13;q14) in acute monocytic leukemia.
  • The recurrent t(10;11)(p13;q14) translocation, usually found in acute myeloid leukemia (AML) and T-ALL, merges PICALM to MLLT10.
  • RT-PCR enabled identification of PICALM-MLLT10 and BCR-ABL1 e1-a2 fusion transcripts; in the context of chronic and acute myeloid leukemia, the latter usually has a monocytic presentation.
  • We also identified overexpression of HOXA9, a gene essential to myeloid differentiation that is expressed in PICALM-MLLT10 and MLL-rearranged acute leukemias.
  • [MeSH-major] Fusion Proteins, bcr-abl / metabolism. Gene Expression Regulation, Neoplastic. Homeodomain Proteins / metabolism. Leukemia, Monocytic, Acute / genetics. Oncogene Proteins, Fusion / metabolism

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16518848.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Homeodomain Proteins; 0 / MLLT10 protein, human; 0 / Monomeric Clathrin Assembly Proteins; 0 / Oncogene Proteins, Fusion; 0 / PICALM protein, human; 0 / PICALM-MLLT10 fusion protein, human; 0 / Transcription Factors; 0 / homeobox protein HOXA9; EC 2.7.10.1 / FLT3 protein, human; EC 2.7.10.1 / fms-Like Tyrosine Kinase 3; EC 2.7.10.2 / Fusion Proteins, bcr-abl
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65. Xu Y, McKenna RW, Wilson KS, Karandikar NJ, Schultz RA, Kroft SH: Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation. Leukemia; 2006 Jul;20(7):1321-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunophenotypic identification of acute myeloid leukemia with monocytic differentiation.
  • [MeSH-major] Immunophenotyping / methods. Leukemia, Myeloid / blood. Leukemia, Myeloid / pathology. Monocytes / pathology

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  • (PMID = 16642046.001).
  • [ISSN] 0887-6924
  • [Journal-full-title] Leukemia
  • [ISO-abbreviation] Leukemia
  • [Language] eng
  • [Publication-type] Letter
  • [Publication-country] England
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66. Altieri A, Castro F, Bermejo JL, Hemminki K: Number of siblings and the risk of lymphoma, leukemia, and myeloma by histopathology. Cancer Epidemiol Biomarkers Prev; 2006 Jul;15(7):1281-6
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  • [Title] Number of siblings and the risk of lymphoma, leukemia, and myeloma by histopathology.
  • Epidemiologic evidence indicates that several markers of exposure to childhood infections are inversely associated with the risk of childhood leukemia and lymphomas.
  • We used the Swedish Family-Cancer Database to assess the effects of number of siblings on the risk of non-Hodgkin's (n = 7,007) and Hodgkin's lymphomas (n = 3,115), leukemias (n = 7,650), and multiple myeloma (n = 1,492) by histopathology.
  • Having four or more siblings compared with none was associated with an excess risk of childhood acute lymphoblastic leukemia [ALL; rate ratio (RR), 2.11; P(trend) = 0.001], acute monocytic leukemia (RR, 2.51; P(trend) = 0.002), and multiple myeloma (RR, 1.34; P(trend) = 0.006).
  • Having three or more older siblings compared with none decreased the risk of acute monocytic leukemia (RR, 0.35; P(trend) = 0.001) and childhood ALL (RR, 0.69; P(trend) = 0.01).
  • Acute myeloid leukemia, chronic lymphocytic leukemia, and other lymphoproliferative malignancies were not associated with number of siblings.
  • In conclusion, we found an excess risk of childhood ALL and acute monocytic leukemia in large families.
  • However, for ALL, acute monocytic leukemia, and Hodgkin's lymphoma, younger siblings were strongly protected compared with older siblings.
  • The remarkable protective effect of number of older siblings on acute monocytic leukemia is a novel finding of potential interest.
  • [MeSH-major] Birth Order. Hodgkin Disease / etiology. Leukemia / etiology. Multiple Myeloma / etiology. Siblings

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  • (PMID = 16835324.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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67. Suzukawa K, Shimizu S, Nemoto N, Takei N, Taki T, Nagasawa T: Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21). Int J Hematol; 2005 Jul;82(1):38-41
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  • [Title] Identification of a chromosomal breakpoint and detection of a novel form of an MLL-AF17 fusion transcript in acute monocytic leukemia with t(11;17)(q23;q21).
  • More than 40 genes have been reported as translocation partners of the mixed lineage leukemia gene (MLL) in hematologic malignancies.
  • On the other hand, there is only 1 report of an MLL-AF17 fusion transcript in acute myeloid leukemia (AML).
  • Here we describe a 40-year-old man with a diagnosis of AML involving t(11;17)(q23;q21).
  • [MeSH-major] Chromosomes, Human, Pair 11. Chromosomes, Human, Pair 17. DNA-Binding Proteins / genetics. Leukemia, Monocytic, Acute / genetics. Myeloid-Lymphoid Leukemia Protein / genetics. Neoplasm Proteins / genetics. Oncogene Proteins, Fusion / genetics

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  • (PMID = 16105757.001).
  • [ISSN] 0925-5710
  • [Journal-full-title] International journal of hematology
  • [ISO-abbreviation] Int. J. Hematol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / MLL protein, human; 0 / MLL-AF17 fusion protein, human; 0 / MLLT6 protein, human; 0 / Neoplasm Proteins; 0 / Oncogene Proteins, Fusion; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase
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68. Gutiérrez NC, López-Pérez R, Hernández JM, Isidro I, González B, Delgado M, Fermiñán E, García JL, Vázquez L, González M, San Miguel JF: Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia. Leukemia; 2005 Mar;19(3):402-9
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  • [Title] Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia.
  • Bone marrow samples from 43 adult patients with de novo diagnosed acute myeloid leukemia (AML)--10 acute promyelocytic leukemias (APL) with t(15;17), four AML with inv(16), seven monocytic leukemias and 22 nonmonocytic leukemias--were analyzed using high-density oligonucleotide microarrays.
  • Hierarchical clustering analysis segregated APL, AML with inv(16), monocytic leukemias and the remaining AML into separate groups.
  • Genes involved in cell adhesion represented the most altered functional category in monocytic leukemias.
  • All the eight leukemias that were either refractory to treatment or that relapsed afterwards were assigned to cluster B.
  • [MeSH-major] Gene Expression Profiling / methods. Gene Expression Regulation, Leukemic. Leukemia, Myeloid, Acute / classification. Leukemia, Myeloid, Acute / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Cluster Analysis. Female. Humans. Leukemia, Monocytic, Acute / genetics. Leukemia, Promyelocytic, Acute / genetics. Male. Middle Aged. Phylogeny. Retrospective Studies


69. van Genderen H, Wielders SJ, Lindhout T, Reutelingsperger CP: Rolling and adhesion of apoptotic monocytes is impaired by loss of functional cell surface-expressed P-selectin glycoprotein ligand-1. J Thromb Haemost; 2006 Jul;4(7):1611-7
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  • To test this hypothesis, etoposide-treated, apoptotic, monocytic cells (human monocytic leukemia cell line [THP-1]) were examined for rolling and adhesion on adherent platelets and for TF expression.
  • Laminar flow adhesion assays specific for interaction between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) revealed that in contrast to non-treated cells, apoptotic cells did not roll or firmly attach on adherent platelets.

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  • (PMID = 16839361.001).
  • [ISSN] 1538-7933
  • [Journal-full-title] Journal of thrombosis and haemostasis : JTH
  • [ISO-abbreviation] J. Thromb. Haemost.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Membrane Glycoproteins; 0 / P-selectin ligand protein; 0 / Phosphatidylserines; 6PLQ3CP4P3 / Etoposide; 9035-58-9 / Thromboplastin
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70. Tsirigotis P, Papageorgiou S, Abatzis D, Athanatou S, Girkas C, Pappa V, Pangalos C, Papageorgiou E, Dervenoulas J, Raptis S: Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis. Cancer Genet Cytogenet; 2005 Aug;161(1):78-81
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  • [Title] Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis.
  • Tetrasomy 8 is an extremely rare chromosome abnormality, one that has been reported in only a few cases with myeloid malignancies.
  • The majority of reported cases consist of acute myelogenous leukemias (AML) of monocytic lineage.
  • In slightly more than half of the patients, tetrasomy 8 was the single cytogenetic abnormality.
  • Here, we report the case of a 25-year-old female patient with monocytic leukemia and tetrasomy 8.
  • [MeSH-major] Aneuploidy. Chromosomes, Human, Pair 8 / genetics. Leukemia, Myeloid, Acute / genetics

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  • (PMID = 16080962.001).
  • [ISSN] 0165-4608
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Li ZJ, Chen ZX, Cen JN, He J: [Overexpression of tissue inhibitor of metalloprotease-2 promotes proliferation and infiltration of human monocytic leukemia cells]. Zhonghua Yi Xue Za Zhi; 2006 Sep 12;86(34):2409-12
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  • [Title] [Overexpression of tissue inhibitor of metalloprotease-2 promotes proliferation and infiltration of human monocytic leukemia cells].
  • OBJECTIVE: To investigate the functional role of human tissue inhibitor of metalloprotease (TIMP)-2 gene on the proliferation and infiltrating capability of human monocytic leukemic cells.
  • METHODS: Human monocytic leukemic cells of the line SHI-1 were cultured and the TIMP-2 expression on the cell membrane was detected by flow cytometry (FCM).
  • Human bone marrow matrix cells (BMMC) of leukemia patient and SHI-1/TIMP-2 cells or SHI-1/MSCV cells were put into the upper layers as experimental groups, and SHI-1/TIMP-2 cells or SHI-1/MSCV cells only, without human BMMC, were put into the upper layers as control groups.
  • Thirty days later 8 mice from each group were killed to observe the tumorigenesis in the organs, especially the central nervous system leukemia (CNL).
  • [MeSH-major] Cell Membrane / metabolism. Cell Proliferation. Leukemia, Monocytic, Acute / metabolism. Leukemia, Monocytic, Acute / pathology. Tissue Inhibitor of Metalloproteinase-2 / biosynthesis
  • [MeSH-minor] Animals. Cell Line, Tumor. Cell Survival. Flow Cytometry. Humans. Leukemia, Experimental / genetics. Leukemia, Experimental / metabolism. Leukemia, Experimental / pathology. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Neoplasm Invasiveness. Neoplasm Transplantation / methods. Transfection. Transplantation, Heterologous

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  • (PMID = 17156653.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 127497-59-0 / Tissue Inhibitor of Metalloproteinase-2
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72. Wan JJ, Cheng B, Wang YF, Mei CL, Liu W, Ke L, He P: [Ghrelin down-regulates ACAT-1 in THP-1 derived foam cells via growth hormone secretagogue receptor-dependent pathway]. Zhonghua Xin Xue Guan Bing Za Zhi; 2009 Nov;37(11):1030-4
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  • METHODS: The human monocytic leukemia cell line (THP-1) was chosen in our study.

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  • (PMID = 20137333.001).
  • [ISSN] 0253-3758
  • [Journal-full-title] Zhonghua xin xue guan bing za zhi
  • [ISO-abbreviation] Zhonghua Xin Xue Guan Bing Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Acyl Coenzyme A; 0 / Ghrelin; 0 / RNA, Messenger; 0 / Receptors, Ghrelin; 97C5T2UQ7J / Cholesterol; EC 2.3.1.9 / ACAT1 protein, human; EC 2.3.1.9 / Acetyl-CoA C-Acetyltransferase
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73. Gaurnier-Hausser A, Tuszynski GP: The immunomodulatory role of angiocidin, a novel angiogenesis inhibitor. Curr Pharm Des; 2009;15(17):1937-48
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  • We have found that the monocytic leukemia cell line THP-1, as well as freshly isolated human peripheral blood monocytes, differentiate into macrophage-like cells when treated with angiocidin.

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  • (PMID = 19519434.001).
  • [ISSN] 1873-4286
  • [Journal-full-title] Current pharmaceutical design
  • [ISO-abbreviation] Curr. Pharm. Des.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / R01 CA 88931
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Adjuvants, Immunologic; 0 / Angiogenesis Inhibitors; 0 / Carrier Proteins; 0 / Cytokines; 0 / PSMD4 protein, human; EC 3.4.25.1 / Proteasome Endopeptidase Complex
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74. Stachowska E, Baśkiewicz-Masiuk M, Dziedziejko V, Gutowska I, Baranowska-Bosiacka I, Marchlewicz M, Dołegowska B, Wiszniewska B, Machaliński B, Chlubek D: Conjugated linoleic acid increases intracellular ROS synthesis and oxygenation of arachidonic acid in macrophages. Nutrition; 2008 Feb;24(2):187-99
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  • However, in vivo studies have shown that the application of trans-10, cis-12 CLA in obese men increased their oxidative stress.
  • METHODS: Monocytes from peripheral blood and human monocytic leukemia cells were used in this study.
  • Monocytes were differentiated to macrophages, and were incubated with 30 microM cis-9, trans-11 CLA and trans-10, cis-12 CLA or linoleic acid for 2 days.

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  • (PMID = 18165130.001).
  • [ISSN] 0899-9007
  • [Journal-full-title] Nutrition (Burbank, Los Angeles County, Calif.)
  • [ISO-abbreviation] Nutrition
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / Isoprostanes; 0 / Linoleic Acids, Conjugated; 0 / PPAR alpha; 0 / Reactive Oxygen Species; 27YG812J1I / Arachidonic Acid; EC 3.1.1.- / Phospholipases A
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75. Zhang C, Liang MY, Wang SM: [Clinical analysis of bicytopenia and pancytopenia during pregnancy]. Zhonghua Fu Chan Ke Za Zhi; 2009 Jul;44(7):488-91
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  • OBJECTIVE: To investigate the diagnosis, management, pregnancy outcome and prognosis of bicytopenia or pancytopenia during pregnancy.
  • RESULTS: According to the clinical data and laboratory findings, the latter including complete blood cell count, reticulocyte count, peripheral smear, serum folate and vitamin B12 level, autoimmune antibody screening, bone marrow smear and biopsy, thirteen patients were diagnosed as having chronic aplastic anemia (CAA), six as having myelodysplastic syndromes (MDS), two as having megaloblastic anemia (MA), one as having paroxysmal nocturnal hemoglobinuria (PNH), one as having Evan's syndrome and one as having acute leukemia.
  • The patient with acute leukemia died of recurrence six months postpartum.
  • Of the 6 patients with MDS, one achieved partial remission, four no remission, and one transformed into acute monocytic leukemia, then refused chemotherapy and was lost follow-up.
  • Diagnosis should be made as soon as possible through appropriate and reasonable laboratory examinations.
  • [MeSH-major] Anemia, Aplastic / therapy. Blood Transfusion. Pancytopenia / therapy. Pregnancy Complications, Hematologic / diagnosis. Pregnancy Complications, Hematologic / therapy. Pregnancy Outcome
  • [MeSH-minor] Adult. Biopsy, Needle. Bone Marrow / pathology. Bone Marrow Examination. Female. Folic Acid / therapeutic use. Follow-Up Studies. Humans. Myelodysplastic Syndromes / diagnosis. Myelodysplastic Syndromes / pathology. Myelodysplastic Syndromes / therapy. Pregnancy. Prognosis. Retrospective Studies. Young Adult


76. Fatahzadeh M, Krakow AM: Manifestation of acute monocytic leukemia in the oral cavity: a case report. Spec Care Dentist; 2008 Sep-Oct;28(5):190-4
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  • [Title] Manifestation of acute monocytic leukemia in the oral cavity: a case report.
  • Within a week he developed signs and symptoms of systemic disease and upon further investigation, he was diagnosed with acute monocytic leukemia to which he succumbed within 72 hours.
  • The implications of gingival bleeding are discussed, and the necessity to consider systemic disease in the differential diagnosis is emphasized.
  • [MeSH-major] Gingival Hemorrhage / etiology. Leukemia, Monocytic, Acute / diagnosis

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  • (PMID = 18782195.001).
  • [ISSN] 0275-1879
  • [Journal-full-title] Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
  • [ISO-abbreviation] Spec Care Dentist
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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77. Leupin N, Kuhn A, Hügli B, Grob TJ, Jaggi R, Tobler A, Delorenzi M, Fey MF: Gene expression profiling reveals consistent differences between clinical samples of human leukaemias and their model cell lines. Br J Haematol; 2006 Nov;135(4):520-3
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  • [Title] Gene expression profiling reveals consistent differences between clinical samples of human leukaemias and their model cell lines.
  • Microarray gene expression profiles of fresh clinical samples of chronic myeloid leukaemia in chronic phase, acute promyelocytic leukaemia and acute monocytic leukaemia were compared with profiles from cell lines representing the corresponding types of leukaemia (K562, NB4, HL60).
  • [MeSH-major] Leukemia / genetics. Tumor Cells, Cultured / metabolism
  • [MeSH-minor] Gene Expression. Gene Expression Profiling / methods. Humans. Leukemia, Monocytic, Acute / genetics. Leukemia, Monocytic, Acute / metabolism. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism. Leukemia, Myeloid / genetics. Leukemia, Promyelocytic, Acute / genetics. Leukemia, Promyelocytic, Acute / metabolism. Up-Regulation

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  • (PMID = 17061979.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1654200
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78. Lee SH, Park C, Jin CY, Kim GY, Moon SK, Hyun JW, Lee WH, Choi BT, Kwon TK, Yoo YH, Choi YH: Involvement of extracellular signal-related kinase signaling in esculetin induced G1 arrest of human leukemia U937 cells. Biomed Pharmacother; 2008 Dec;62(10):723-9
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  • [Title] Involvement of extracellular signal-related kinase signaling in esculetin induced G1 arrest of human leukemia U937 cells.
  • This study was conducted to further elucidate the possible mechanisms by which esculetin, a coumarin compound, exerts its anti-proliferative action on cultured human monocytic leukemia U937 cells.

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  • (PMID = 18222060.001).
  • [ISSN] 1950-6007
  • [Journal-full-title] Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
  • [ISO-abbreviation] Biomed. Pharmacother.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cyclin E; 0 / E2F1 Transcription Factor; 0 / Retinoblastoma Protein; 0 / Umbelliferones; 147604-94-2 / Cyclin-Dependent Kinase Inhibitor p27; EC 2.7.11.22 / Cyclin-Dependent Kinase 2; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; SM2XD6V944 / esculetin
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79. Himeji M, Ohtsuki T, Fukazawa H, Tanaka M, Yazaki S, Ui S, Nishio K, Yamamoto H, Tasaka K, Mimura A: Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett; 2007 Jan 8;245(1-2):269-74
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  • Methanol extract from cultured Scutellaria baicalensis cells inhibited the proliferation of human monocytic leukemia cell line THP-1 and human osteogenic sarcoma cell line HOS.

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  • (PMID = 16497434.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Drugs, Chinese Herbal; 0 / Flavanones; 0 / Flavonoids; 0 / Growth Inhibitors; 0 / Plant Extracts; 347Q89U4M5 / baicalin; 49QAH60606 / baicalein; 632-85-9 / wogonin
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80. Demirer S, Ozdemir H, Sencan M, Marakoglu I: Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: a case report. Eur J Dent; 2007 Apr;1(2):111-4
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  • [Title] Gingival hyperplasia as an early diagnostic oral manifestation in acute monocytic leukemia: a case report.
  • Acute Myeloblastic Leukemia (AML) is a malignant disease of bone marrow.
  • Due to its high morbidity rate, early diagnosis and appropriate medical therapy is essential.
  • A medical consultation was asked from hematology clinics and after a detailed medical examination Acute Monocytic Leukemia (FAB M5) was rendered.
  • Also, early medical therapy in acute monocytic leukemia may resolve the gingival hyperplasia that companies the disease progression.

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  • (PMID = 19212486.001).
  • [ISSN] 1305-7456
  • [Journal-full-title] European journal of dentistry
  • [ISO-abbreviation] Eur J Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Turkey
  • [Other-IDs] NLM/ PMC2609944
  • [Keywords] NOTNLM ; Acute monocytic leukemia / Gingival hyperplasia
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81. Kuniyasu H, Yano S, Sasaki T, Sasahira T, Sone S, Ohmori H: Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages. Am J Pathol; 2005 Mar;166(3):751-60
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  • To investigate HMGB1/amphoterin effects on macrophages, U937 human monocytic leukemia cells and rat peritoneal and human alveolar macrophages were examined.
  • [MeSH-minor] Animals. Cell Line. Cell Line, Tumor. Cell Proliferation. Coculture Techniques. Culture Media, Conditioned / pharmacology. Glycosylation End Products, Advanced / metabolism. Humans. Immunoblotting. MAP Kinase Signaling System. Nitric Oxide Synthase / metabolism. Nitric Oxide Synthase Type II. Nitrites / metabolism. Oligonucleotides / chemistry. Oligonucleotides, Antisense / chemistry. Rats. Rats, Inbred F344. Recombinant Proteins / chemistry. Signal Transduction. Tetradecanoylphorbol Acetate. Time Factors. U937 Cells

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  • (PMID = 15743787.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Culture Media, Conditioned; 0 / Glycosylation End Products, Advanced; 0 / HMGB1 Protein; 0 / Nitrites; 0 / Oligonucleotides; 0 / Oligonucleotides, Antisense; 0 / Recombinant Proteins; EC 1.14.13.39 / NOS2 protein, human; EC 1.14.13.39 / Nitric Oxide Synthase; EC 1.14.13.39 / Nitric Oxide Synthase Type II; EC 1.14.13.39 / Nos2 protein, rat; NI40JAQ945 / Tetradecanoylphorbol Acetate
  • [Other-IDs] NLM/ PMC1602344
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82. Yamamoto M, Hirano S, Vogel CF, Cui X, Matsumura F: Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells. J Biochem Mol Toxicol; 2008 Mar-Apr;22(2):136-46
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  • [Title] Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells.
  • Arsenite has been reported to exert dose-dependent dual effects: triggering apoptosis at relatively high concentrations, whereas inducing partial differentiation at low concentrations in leukemia cells.

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  • [Copyright] 2008 Wiley Periodicals, Inc.
  • (PMID = 18418899.001).
  • [ISSN] 1099-0461
  • [Journal-full-title] Journal of biochemical and molecular toxicology
  • [ISO-abbreviation] J. Biochem. Mol. Toxicol.
  • [Language] eng
  • [Grant] United States / NIEHS NIH HHS / ES / ES05233; United States / NIEHS NIH HHS / ES / ES05707
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Arsenites; 0 / DNA Primers; 0 / E2F Transcription Factors; 0 / NF-kappa B; 0 / RNA, Messenger; N5509X556J / arsenite; NI40JAQ945 / Tetradecanoylphorbol Acetate
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83. Rokudai S, Aikawa Y, Tagata Y, Tsuchida N, Taya Y, Kitabayashi I: Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest. J Biol Chem; 2009 Jan 2;284(1):237-44
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  • [Title] Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest.
  • Here we show that monocytic leukemia zinc finger (MOZ) forms a complex with p53 to induce p21 expression and cell-cycle arrest.
  • The leukemia-associated MOZ-CBP fusion protein inhibits p53-mediated transcription.

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  • (PMID = 19001415.001).
  • [ISSN] 0021-9258
  • [Journal-full-title] The Journal of biological chemistry
  • [ISO-abbreviation] J. Biol. Chem.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CDKN1A protein, human; 0 / Cdkn1a protein, mouse; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Recombinant Fusion Proteins; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53; EC 2.3.1.48 / Histone Acetyltransferases; EC 2.3.1.48 / KAT6A protein, human; EC 2.3.1.48 / MOZ protein, mouse
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84. Amchenkova AM, Narovlianskiĭ AN, Cheknev SB, Bartova LM, Kulagina NN: [The capacity of fusicoccin for inducing the synthesis of early interferon]. Zh Mikrobiol Epidemiol Immunobiol; 2005 Jul-Aug;(4):80-2
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  • The metabolism of actively proliferating monocytic leukemia cells J-96 and human ovarian carcinoma cells CaOv, as well as mouse fibroblasts L-929, was found to be inhibited under the in vitro action of FC.

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  • (PMID = 16146236.001).
  • [ISSN] 0372-9311
  • [Journal-full-title] Zhurnal mikrobiologii, epidemiologii, i immunobiologii
  • [ISO-abbreviation] Zh. Mikrobiol. Epidemiol. Immunobiol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Glycosides; 0 / Mycotoxins; 20108-30-9 / fusicoccin; 9008-11-1 / Interferons
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85. Baumann B, Seufert J, Rolf O, Jakob F, Goebel S, Eulert J, Rader CP: Upregulation of LITAF mRNA expression upon exposure to TiAlV and polyethylene wear particles in THP-1 macrophages. Biomed Tech (Berl); 2007 Apr;52(2):200-7
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  • A human monocytic leukemia cell line (THP-1) was used in this in vitro study.

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  • (PMID = 17408380.001).
  • [ISSN] 0013-5585
  • [Journal-full-title] Biomedizinische Technik. Biomedical engineering
  • [ISO-abbreviation] Biomed Tech (Berl)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / RNA, Messenger; 12743-70-3 / titanium alloy (TiAl6V4); 9002-88-4 / Polyethylene; D1JT611TNE / Titanium
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86. Uchide N, Tadera C, Sarai H, Ohyama K, Bessho T, Toyoda H: Characterization of monocyte differentiation-inducing (MDI) factors derived from human fetal membrane chorion cells undergoing apoptosis after influenza virus infection. Int J Biochem Cell Biol; 2006;38(11):1926-38
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  • In this study, cellular, biological and immunochemical characteristics of MDI factors were investigated using human monocytic leukemia THP-1 cells by nitroblue tetrazolium reduction and cell adhesion assays.
  • The phenomenon was also observed in human peripheral blood monocytes and histiocytic leukemia U937 cells, but not in promyelocytic leukemia HL-60 cells.

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  • (PMID = 16824780.001).
  • [ISSN] 1357-2725
  • [Journal-full-title] The international journal of biochemistry & cell biology
  • [ISO-abbreviation] Int. J. Biochem. Cell Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Interleukin-6
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87. Sakaguchi H, Ashikaga T, Miyazawa M, Yoshida Y, Ito Y, Yoneyama K, Hirota M, Itagaki H, Toyoda H, Suzuki H: Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT. Toxicol In Vitro; 2006 Aug;20(5):774-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • In our previous study, we suggested that measuring CD86 and/or CD54 expression on THP-1 cells (human monocytic leukemia cell line) could be used as an in vitro skin sensitization method.
  • We measured the expression of CD86 and CD54 on the above cells using flow cytometry after a 24h and 48h exposure to six known allergens (e.g., DNCB, pPD, NiSO(4)) and three non-allergens (e.g., SLS, tween 80).
  • We found that allergens/non-allergens were better predicted using THP-1 cells compared to U-937 cells following a 24 h and a 48 h exposure.
  • Both laboratories gave a good prediction of allergen/non-allergen, especially using THP-1 cells.

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  • (PMID = 16337770.001).
  • [ISSN] 0887-2333
  • [Journal-full-title] Toxicology in vitro : an international journal published in association with BIBRA
  • [ISO-abbreviation] Toxicol In Vitro
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Allergens; 0 / Antigens, CD4; 0 / Antigens, CD86
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88. Yamamoto K, Okamura A, Wakahashi K, Katayama Y, Shimoyama M, Matsui T: A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia. Cancer Genet Cytogenet; 2010 Jun;199(2):134-8
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  • [Title] A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia.
  • We describe here a novel unbalanced whole-arm translocation der(3;10)(q10;q10) in a 58-year-old man with acute monocytic leukemia.
  • These monocytic cells were positive for myeloperoxidase and alpha-naphthyl butyrate esterase staining.
  • Spectral karyotyping confirmed der(3;10)(q10;q10) as a sole structural abnormality.
  • The +3,der(3;10)(q10;q10) is thought to play a crucial role in the pathogenesis of acute monocytic leukemia because of the gain of 3q or the loss of 10p.
  • [MeSH-major] Chromosomes, Human, Pair 10 / genetics. Chromosomes, Human, Pair 3 / genetics. Leukemia, Monocytic, Acute / genetics. Translocation, Genetic / genetics

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  • [Copyright] Copyright 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20471517.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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89. Tariku Y, Hymete A, Hailu A, Rohloff J: Constituents, antileishmanial activity and toxicity profile of volatile oil from berries of Croton macrostachyus. Nat Prod Commun; 2010 Jun;5(6):975-80
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  • The oil was tested for its in vitro antileishmanial activity on two Leishmania strains, and its toxicity on the human monocytic leukemia (THP-1) cell line and erythrocytes from sheep blood.

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  • (PMID = 20614838.001).
  • [ISSN] 1934-578X
  • [Journal-full-title] Natural product communications
  • [ISO-abbreviation] Nat Prod Commun
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antiprotozoal Agents; 0 / Oils, Volatile; 0 / Plant Oils
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90. Wu HY, Chang AC, Wang CC, Kuo FH, Lee CY, Liu DZ, Jan TR: Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes. Toxicol Appl Pharmacol; 2010 Aug 1;246(3):141-7
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  • It has been documented that cannabidiol (CBD) induced apoptosis in a variety of transformed cells, including lymphocytic and monocytic leukemias.

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20471992.001).
  • [ISSN] 1096-0333
  • [Journal-full-title] Toxicology and applied pharmacology
  • [ISO-abbreviation] Toxicol. Appl. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Protoporphyrins; 0 / Sulfhydryl Compounds; 15442-64-5 / zinc protoporphyrin; 19GBJ60SN5 / Cannabidiol; 80168379AG / Doxorubicin; EC 1.14.99.3 / HMOX1 protein, human; EC 1.14.99.3 / Heme Oxygenase-1; GAN16C9B8O / Glutathione; WYQ7N0BPYC / Acetylcysteine
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91. Paggetti J, Largeot A, Aucagne R, Jacquel A, Lagrange B, Yang XJ, Solary E, Bastie JN, Delva L: Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells. Oncogene; 2010 Sep 9;29(36):5019-31
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  • [Title] Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.
  • MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia.
  • In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, abnormal levels of HOX transcription factors have been found to be critical for leukemogenesis.
  • [MeSH-major] Antigens, CD34 / metabolism. Fetal Blood / metabolism. Histone Acetyltransferases / physiology. Homeodomain Proteins / genetics. Myeloid-Lymphoid Leukemia Protein / physiology

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  • (PMID = 20581860.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Histones; 0 / Homeodomain Proteins; 0 / MLL protein, human; 0 / WDR5 protein, human; 149025-06-9 / Myeloid-Lymphoid Leukemia Protein; EC 2.1.1.43 / Histone-Lysine N-Methyltransferase; EC 2.3.1.48 / Histone Acetyltransferases; EC 2.3.1.48 / KAT6A protein, human
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92. Stahnke B, Thepen T, Stöcker M, Rosinke R, Jost E, Fischer R, Tur MK, Barth S: Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes. Mol Cancer Ther; 2008 Sep;7(9):2924-32
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  • [Title] Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes.
  • Acute myeloid leukemia (AML) cells of subtypes M4 and M5 show enhanced expression of CD64 (FcgammaRI), the high-affinity receptor for IgG, which is normally expressed at high levels only on activated cells of the myeloid lineage.
  • [MeSH-major] Granzymes / pharmacology. Immunoglobulin Variable Region / pharmacology. Immunotoxins / pharmacology. Leukemia, Monocytic, Acute / metabolism. Receptors, IgG / antagonists & inhibitors. Recombinant Fusion Proteins / pharmacology

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  • (PMID = 18790773.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Variable Region; 0 / Immunotoxins; 0 / Receptors, IgG; 0 / Recombinant Fusion Proteins; EC 3.4.21.- / Granzymes; EC 3.4.22.- / Caspase 3
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93. Sakaguchi H, Ashikaga T, Miyazawa M, Kosaka N, Ito Y, Yoneyama K, Sono S, Itagaki H, Toyoda H, Suzuki H: The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test--human cell line activation test (h-CLAT). Cell Biol Toxicol; 2009 Apr;25(2):109-26
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  • Yet, there is not an acceptable Organization for Economic Co-operation and Development non-animal skin sensitization test method.
  • In our previous study, we optimized our human cell line activation test (h-CLAT) using THP-1 cells (monocytic leukemia cell line) and conducted an inter-laboratory study.
  • In this study, 21 allergens (e.g., dinitrochlorobenzene, p-phenylenediamine, Ni) and 8 non-allergens (e.g., SLS, lactic acid) were evaluated.

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  • (PMID = 18204907.001).
  • [ISSN] 1573-6822
  • [Journal-full-title] Cell biology and toxicology
  • [ISO-abbreviation] Cell Biol. Toxicol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Allergens; 0 / Antibodies, Monoclonal; 0 / Antigens, CD86; 126547-89-5 / Intercellular Adhesion Molecule-1
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94. Hu XR, He JS, Ye XJ, Zheng WY, Wu WJ, Lin MF: Candida tropicalis arthritis in a patient with acute leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2008 Oct;16(5):1215-8
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  • [Title] Candida tropicalis arthritis in a patient with acute leukemia.
  • A case of Candida tropicalis arthritis of knee occurred in a patient with acute monocytic leukemia was reported during the recovery phase of post chemotherapy myelosuppression and agranulocytosis.

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  • (PMID = 18928631.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antifungal Agents
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95. Laengle UW, Markstein R, Cazaubon C, Roman D: Antiglaucoma drug GLC756 and its effect on cellular cAMP and tumor necrosis factor alpha release in vitro of activated human monocytic leukemia cells. Jpn J Ophthalmol; 2009 Mar;53(2):159-63
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  • [Title] Antiglaucoma drug GLC756 and its effect on cellular cAMP and tumor necrosis factor alpha release in vitro of activated human monocytic leukemia cells.
  • The present study describes the effects of GLC756 on cellular adenosine 3', 5'-cyclic monophosphate (cAMP) in relation to TNF-alpha production on LPS-stimulated human acute monocytic leukemia cells.
  • METHODS: A human peripheral blood acute monocytic leukemia cell line (THP-1) was activated via LPS.
  • [MeSH-major] Antihypertensive Agents / pharmacology. Cyclic AMP / metabolism. Leukemia, Monocytic, Acute / drug therapy. Quinolines / pharmacology. Tumor Necrosis Factor-alpha / metabolism

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  • (PMID = 19333701.001).
  • [ISSN] 1613-2246
  • [Journal-full-title] Japanese journal of ophthalmology
  • [ISO-abbreviation] Jpn. J. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antihypertensive Agents; 0 / Glucocorticoids; 0 / Lipopolysaccharides; 0 / Ophthalmic Solutions; 0 / Quinolines; 0 / Receptors, Dopamine D1; 0 / Receptors, Dopamine D2; 0 / SDZ GLC 756; 0 / Tumor Necrosis Factor-alpha; 9842X06Q6M / Betamethasone; E0399OZS9N / Cyclic AMP
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96. Wu HJ, Chen Y: [Biological characteristics of hyperleukocytic acute leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2006 Jun;14(3):450-4
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  • [Title] [Biological characteristics of hyperleukocytic acute leukemia].
  • The study was to investigate the biological characteristics of hyperleucocyte acute leukemia (HAL) and its clinical significance.
  • In AML, monocytic leukemia is easier to become into HAL than other leukemias.
  • In ALL, T-lineage antigens of HAL group are more easily expressed than those of NHAL group; the leukemia cells of HAL group are naiver than those of NHAL group, meanwhile the prognosis of HAL is poor.

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  • (PMID = 16800918.001).
  • [ISSN] 1009-2137
  • [Journal-full-title] Zhongguo shi yan xue ye xue za zhi
  • [ISO-abbreviation] Zhongguo Shi Yan Xue Ye Xue Za Zhi
  • [Language] CHI
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD14; 0 / Antigens, CD79; 0 / Antigens, CD8; 0 / Sialic Acid Binding Ig-like Lectin 2
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97. Ferreri C, Kratzsch S, Brede O, Marciniak B, Chatgilialoglu C: Trans lipid formation induced by thiols in human monocytic leukemia cells. Free Radic Biol Med; 2005 May 1;38(9):1180-7
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  • [Title] Trans lipid formation induced by thiols in human monocytic leukemia cells.
  • An endogenous path comprising a thiyl radical-catalyzed cis-trans isomerization of cis-unsaturated phospholipids was proposed.
  • Here we report the presence of trans lipids in human monocytic leukemia cell membranes (THP-1) before and after treatment with a 10 mM series of thiols.
  • These results offer the first evidence that trans lipids are formed in eukaryotic cells and confirm that thiyl radicals are harmful to the integrity of cis lipid geometry.
  • [MeSH-major] Leukemia / metabolism. Membrane Lipids / biosynthesis. Phospholipids / biosynthesis. Sulfhydryl Compounds / physiology

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  • (PMID = 15808415.001).
  • [ISSN] 0891-5849
  • [Journal-full-title] Free radical biology & medicine
  • [ISO-abbreviation] Free Radic. Biol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Membrane Lipids; 0 / Phospholipids; 0 / Sulfhydryl Compounds
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98. Kumarappan CT, Mandal SC: Antitumor activity of polyphenolic extract of Ichnocarpus frutescens. Exp Oncol; 2007 Jun;29(2):94-101
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  • PPE cytotoxicity was determined in vitro in U-937 monocytoid leukemia and K-562 erythroleukemia cell lines.
  • [MeSH-minor] Animals. Antioxidants / pharmacology. Body Weight / drug effects. Carcinoma, Ehrlich Tumor / drug therapy. Cell Count. Cell Line, Tumor. Cell Proliferation / drug effects. Cell Survival / drug effects. Dose-Response Relationship, Drug. Female. Free Radical Scavengers / pharmacology. Humans. Inhibitory Concentration 50. K562 Cells. Leukemia, Erythroblastic, Acute / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Male. Mice. Neoplasm Transplantation. Nitric Oxide / chemistry. Nitric Oxide / metabolism. Plant Leaves / chemistry. Polyphenols. Solvents / chemistry. Superoxides / metabolism. Survival Rate. Toxicity Tests, Acute. Transplantation, Homologous. Tumor Burden / drug effects. U937 Cells. alpha-Tocopherol / pharmacology

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  • (PMID = 17704739.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; 0 / Antioxidants; 0 / Flavonoids; 0 / Free Radical Scavengers; 0 / Phenols; 0 / Plant Extracts; 0 / Polyphenols; 0 / Solvents; 11062-77-4 / Superoxides; 31C4KY9ESH / Nitric Oxide; H4N855PNZ1 / alpha-Tocopherol
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99. Kumagai Y, Cheng Z, Lin M, Rikihisa Y: Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion. Infect Immun; 2006 Sep;74(9):5014-22
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  • Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, replicates in early endosomes by avoiding lysosomal fusion in monocytes and macrophages.
  • Closantel treatment induced lysosomal fusion of the E. chaffeensis inclusion in a human monocytic leukemia cell line, THP-1 cells, implying that functional TCSs are essential in preventing lysosomal fusion of the E. chaffeensis inclusion compartment.

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  • (PMID = 16926392.001).
  • [ISSN] 0019-9567
  • [Journal-full-title] Infection and immunity
  • [ISO-abbreviation] Infect. Immun.
  • [Language] ENG
  • [Grant] United States / NIAID NIH HHS / AI / R01 AI047885; United States / NIAID NIH HHS / AI / R01 AI054476; United States / NIAID NIH HHS / AI / R01 AI 054476; United States / NIAID NIH HHS / AI / R01 AI 47885
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bacterial Proteins; 0 / Protein Kinase Inhibitors; 0 / Recombinant Proteins; 0 / Salicylanilides; 0 / Trans-Activators; 0 / osmolarity response regulator proteins; EC 2.7.- / Protein Kinases; EC 2.7.3.- / protein-histidine kinase; EUL532EI54 / closantel
  • [Other-IDs] NLM/ PMC1594868
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100. Xu N, Liu XL, DU QF, Liu Z, Zhong M, Lin R, Song LL, Yi ZS, Meng FY, Zhou SY: [CD56 and CD11b antigen expressions in patients with acute monocytic leukemia and the clinical implications]. Nan Fang Yi Ke Da Xue Xue Bao; 2009 Aug;29(8):1605-8
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  • [Title] [CD56 and CD11b antigen expressions in patients with acute monocytic leukemia and the clinical implications].
  • OBJECTIVE: To investigate the expressions of cell surface differentiation antigen CD56 and CD11b antigen in acute monocytic leukemic (AML-M(5)) cells and their clinical significance.
  • Compared with the patients positive for both CD56 and CD11b, those negative for both CD56 and CD11b showed increased peripheral blood white blood cell (WBC) count and also increased blast and progenitor cells in the bone marrow (P<0.05); the former patients often had karyotypic abnormalities, commonly involving 11q23 aberrations (P<0.05), whereas the latter patients presented more likely with extramedullary infiltration and refractory leukemia (P<0.01) with lowered complete remission rate and shortened median survival time (P<0.01).
  • CD56-positive patients were more likely to have karyotypic abnormalities and refractory leukemia than CD11b-postive patients (P<0.05), but the peripheral blood WBC counts, bone marrow blast and progenitor cells, extramedullary infiltration, complete remission rate or median survival time showed no significant differences between them (P>0.05).
  • CONCLUSION: AML-M(5) patients with CD56 positivity and high expression of CD11b often have aberrant karyotypes, commonly involving 11q23/MLL gene abnormality.
  • These patients frequently develop extramedullary infiltration and refractory leukemia often with poor prognosis.
  • [MeSH-major] Antigens, CD11b / metabolism. Antigens, CD56 / metabolism. Gene Expression Regulation. Leukemia, Monocytic, Acute / metabolism

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  • (PMID = 19726305.001).
  • [ISSN] 1673-4254
  • [Journal-full-title] Nan fang yi ke da xue xue bao = Journal of Southern Medical University
  • [ISO-abbreviation] Nan Fang Yi Ke Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD11b; 0 / Antigens, CD56
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