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1. Dingli D, Kyle RA, Rajkumar SV, Nowakowski GS, Larson DR, Bida JP, Gertz MA, Therneau TM, Melton LJ 3rd, Dispenzieri A, Katzmann JA: Immunoglobulin free light chains and solitary plasmacytoma of bone. Blood; 2006 Sep 15;108(6):1979-83
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  • [Title] Immunoglobulin free light chains and solitary plasmacytoma of bone.
  • An abnormal serum immunoglobulin free light chain (FLC) ratio at diagnosis may identify risk of progression to myeloma in patients with solitary bone plasmacytoma (SBP).
  • In the cohort of 116 patients, 43 have progressed to myeloma, with a median time to progression of 1.8 years.
  • The FLC ratio was determined in all 116 patients on serum collected at time of diagnosis and was abnormal in 54 patients (47%).
  • An abnormal FLC ratio was associated with a higher risk of progression to myeloma (P = .039).
  • The risk of progression at 5 years was 44% in patients with an abnormal serum FLC ratio at diagnosis compared with 26% in those with a normal FLC ratio.
  • One to 2 years following diagnosis, a persistent serum M protein level of 5 g/L (0.5 g/dL) or higher was an additional risk factor for progression.
  • A risk stratification model was constructed using the 2 variables of FLC ratio and M protein level: patients with a normal FLC ratio at baseline and M protein level less than 5 g/L (0.5 g/dL) at 1 to 2 years following diagnosis (low risk, n = 31); with either risk factor abnormal (intermediate risk, n = 26); and with both an abnormal FLC ratio and M protein level of 5 g/L (0.5 g/dL) or higher (high risk, n = 18).

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  • (PMID = 16741249.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA 100080; United States / NCI NIH HHS / CA / CA 62242; United States / NCI NIH HHS / CA / CA 85818; United States / NCI NIH HHS / CA / CA 93842
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin Light Chains; 0 / Myeloma Proteins
  • [Other-IDs] NLM/ PMC1895544
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2. Qi CF, Shin DM, Li Z, Wang H, Feng J, Hartley JW, Fredrickson TN, Kovalchuk AL, Morse HC 3rd: Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice. J Pathol; 2010 May;221(1):106-16
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  • [Title] Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice.
  • Anaplastic plasmacytomas (APCTs) from NFS.V(+) congenic mice and pristane-induced plasmacytic PCTs from BALB/c mice were previously shown to be histologically and molecularly distinct subsets of plasma cell neoplasms (PCNs).
  • Here we extended these comparisons, contrasting primary APCTs and PCTs by gene expression profiling in relation to the expression profiles of normal naïve, germinal centre, and memory B cells and plasma cells.
  • We also sequenced immunoglobulin genes from APCT and APCT-derived cell lines and defined surface phenotypes and chromosomal features of the cell lines by flow cytometry and by spectral karyotyping and fluorescence in situ hybridization.
  • The results indicate that APCTs share many features with normal memory cells and the plasma cell-related neoplasms (PLs) of FASL-deficient mice, suggesting that APCTs and PLs are related and that both derive from memory B cells.
  • [MeSH-major] B-Lymphocyte Subsets / immunology. Immunologic Memory. Murine Acquired Immunodeficiency Syndrome / immunology. Neoplasms, Plasma Cell / immunology. Plasmacytoma / immunology
  • [MeSH-minor] Animals. Base Sequence. Cell Survival / physiology. Chromosome Aberrations. Gene Expression Profiling / methods. Immunoglobulin Variable Region / genetics. Mice. Mice, Inbred BALB C. Molecular Sequence Data. Neoplasm Proteins / metabolism. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction / methods. Signal Transduction / physiology. Tumor Cells, Cultured

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  • (PMID = 20217872.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / ZIA AI000858-11
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Immunoglobulin Variable Region; 0 / Neoplasm Proteins
  • [Other-IDs] NLM/ NIHMS393403; NLM/ PMC3415987
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3. Qi CF, Zhou JX, Lee CH, Naghashfar Z, Xiang S, Kovalchuk AL, Fredrickson TN, Hartley JW, Roopenian DC, Davidson WF, Janz S, Morse HC 3rd: Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Cancer Res; 2007 Mar 15;67(6):2439-47
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  • [Title] Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells.
  • We have compared histologic features and gene expression profiles of newly identified plasmacytomas from NFS.V(+) congenic mice with plasmacytomas of IL6 transgenic, Fasl mutant, and SJL-beta2M(-/-) mice.
  • NFS.V(+) tumors comprised an overlapping morphologic spectrum of high-grade/anaplastic, intermediate-grade/plasmablastic, and low-grade/plasmacytic cases with similarities to subsets of human multiple myeloma and plasmacytoma.
  • Microarray and immunohistochemical analyses of genes expressed by the most prevalent tumors, plasmablastic plasmacytomas, showed them to be most closely related to immunoblastic lymphomas, less so to plasmacytomas of Fasl mutant and SJL mice, and least to plasmacytic plasmacytomas of IL6 transgenic mice.
  • Plasmablastic tumors seemed to develop in an inflammatory environment associated with gene signatures of T cells, natural killer cells, and macrophages not seen with plasmacytic plasmacytomas.
  • Plasmablastic plasmacytomas from NFS.V(+) and SJL-beta2M(-/-) mice did not have structural alterations in Myc or T(12;15) translocations and did not express Myc at high levels, regular features of transgenic and pristane-induced plasmacytomas.
  • These findings imply that, as for human multiple myeloma, Myc-independent routes of transformation contribute to the pathogenesis of these tumors.
  • These findings suggest that plasma cell neoplasms of mice and humans exhibit similar degrees of complexity.
  • Mouse plasmacytomas, previously considered to be homogeneous, may thus be as diverse as their human counterparts with respect to oncogenic mechanisms of plasma cell transformation.
  • Selecting specific types of mouse plasmacytomas that relate most closely to subtypes of human multiple myeloma may provide new opportunities for preclinical testing of drugs for treatment of the human disease.
  • [MeSH-major] B-Lymphocytes / pathology. Plasmacytoma / pathology
  • [MeSH-minor] Animals. Cell Differentiation / physiology. Cell Lineage. Gene Expression Profiling. Genes, myc. Humans. Immunohistochemistry. Interleukin-6 / genetics. Mice. Mice, Inbred BALB C. Mice, Knockout. Mice, Transgenic. Neoplasm Staging

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  • (PMID = 17363561.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA34196; United States / NCI NIH HHS / CA / CA82872-02; United States / NIDDK NIH HHS / DK / DK56597
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-6
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4. Han SS, Peng L, Chung ST, DuBois W, Maeng SH, Shaffer AL, Sporn MB, Janz S: CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. Mol Cancer; 2006 Jun 07;5:22
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  • [Title] CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms.
  • BACKGROUND: Gene-targeted iMycEmu mice that carry a His6-tagged mouse Myc(c-myc)cDNA, MycHis, just 5' of the immunoglobulin heavy-chain enhancer, Emu, are prone to B cell and plasma cell neoplasms, such as lymphoblastic B-cell lymphoma (LBL) and plasmacytoma (PCT).
  • Cell lines derived from Myc-induced neoplasms of this sort may provide a good model system for the design and testing of new approaches to prevent and treat MYC-driven B cell and plasma cell neoplasms in human beings.
  • To test this hypothesis, we used the LBL-derived cell line, iMycEmu-1, and the newly established PCT-derived cell line, iMycEmu-2, to evaluate the growth inhibitory and death inducing potency of the cancer drug candidate, CDDO-imidazolide (CDDO-Im).
  • Cell cycle progression and apoptosis were analyzed by FACS.
  • CDDO-Im-dependent growth inhibition and apoptosis were associated in both cell lines with the up-regulation of 30 genes involved in apoptosis, cell cycling, NFkappaB signaling, and stress and toxicity responses.
  • CONCLUSION: Growth arrest and killing of neoplastic mouse B cells and plasma cells by CDDO-Im, a closely related derivative of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid, appears to be caused, in part, by drug-induced stress responses and reduction of Myc.

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  • (PMID = 16759389.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; 0 / DNA, Complementary; 0 / Imidazolidines; 0 / NF-kappa B; 0 / Proto-Oncogene Proteins c-myc; 6SMK8R7TGJ / Oleanolic Acid
  • [Other-IDs] NLM/ PMC1553469
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5. Gaur S, Oo TH, Aish LS, Mansoor S: Gastric relapse of solitary bone plasmacytoma. Am J Clin Oncol; 2005 Jun;28(3):325-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric relapse of solitary bone plasmacytoma.
  • This case report describes a patient with solitary bone plasmacytoma who had a gastric relapse of his tumor.
  • Skeletal surveys, magnetic resonance imaging of the spine, and bone marrow examination done at the time of relapse failed to show any other site of disease.
  • Positron emission tomography finally clarified the true extent of the tumor.
  • [MeSH-major] Plasmacytoma / secondary. Spinal Neoplasms / pathology. Stomach Neoplasms / secondary. Thoracic Vertebrae / pathology
  • [MeSH-minor] Aged. Antibodies, Monoclonal / blood. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Bone Neoplasms / drug therapy. Bone Neoplasms / radionuclide imaging. Bone Neoplasms / secondary. Combined Modality Therapy. Dexamethasone / administration & dosage. Fractures, Spontaneous / etiology. Gastrectomy. Humans. Immunoglobulin A / blood. Magnetic Resonance Imaging. Male. Neoplasm Proteins / blood. Spinal Fractures / etiology. Thalidomide / administration & dosage

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  • (PMID = 15923810.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Immunoglobulin A; 0 / Neoplasm Proteins; 4Z8R6ORS6L / Thalidomide; 7S5I7G3JQL / Dexamethasone
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6. Jagadeesan J, Oudit D, Hardwicke J, Shariff Z, McCoubrey G, Roberts G, Howcroft A: Solitary plasmocytoma of frontal bone presenting as an asymptomatic forehead lump. Dermatol Online J; 2006;12(3):24
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  • [Title] Solitary plasmocytoma of frontal bone presenting as an asymptomatic forehead lump.
  • Solitary plasmocytoma of bone is a rare type of plasma cell tumor.
  • We present a case of a solitary extramedullary plasmacytoma of the frontal bone presenting as an asymptomatic forehead lump with clinically benign characteristics.
  • [MeSH-major] Frontal Bone. Plasmacytoma / pathology. Skull Neoplasms / pathology

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  • (PMID = 16638438.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
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7. Bazarbacha HM, Jeribi R, Zidi MT, Soukri I, Sebaï R, Belghith L, Touibi S: [Plasmocytoma of the skull base revealing multiple myeloma]. J Radiol; 2005 Dec;86(12 Pt 1):1810-2
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  • [Title] [Plasmocytoma of the skull base revealing multiple myeloma].
  • [Transliterated title] Plasmocytome de la base du crâne révélant un myélome multiple.
  • We report a case of sphenoidal plasmocytoma in a 57-year-old male revealing multiple myeloma.
  • MRI showed a tumor located in the sphenoid sinus with local extension.
  • Diagnosis was made by histology after transsphenoidal resection.
  • We discuss the imaging features of plasmocytomas and review the principal differential diagnoses.
  • [MeSH-major] Magnetic Resonance Imaging. Multiple Myeloma / diagnosis. Neoplasms, Multiple Primary / diagnosis. Plasmacytoma / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 16333233.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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8. Park SS, Kim JS, Tessarollo L, Owens JD, Peng L, Han SS, Tae Chung S, Torrey TA, Cheung WC, Polakiewicz RD, McNeil N, Ried T, Mushinski JF, Morse HC 3rd, Janz S: Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res; 2005 Feb 15;65(4):1306-15
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  • [Title] Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.
  • The insertion of Myc(His) mimicked both the human t(8;14)(q24;q32) translocation that results in the activation of MYC in human endemic Burkitt lymphomas and the homologous mouse T(12;15) translocation that deregulates Myc in certain mouse plasmacytomas.
  • Beginning at the age of 6 months, Myc(His) transgenic mice developed B-cell and plasma neoplasms, such as IgM(+) lymphoblastic B-cell lymphomas, Bcl-6(+) diffuse large B-cell lymphomas, and CD138(+) plasmacytomas, with an overall incidence of 68% by 21 months.
  • Molecular studies of lymphoblastic B-cell lymphoma, the most prevalent neoplasm (50% of all tumors), showed that the lymphomas were clonal, overexpressed Myc(His), and exhibited the P2 to P1 promoter shift in Myc expression, a hallmark of MYC/Myc deregulation in human endemic Burkitt lymphoma and mouse plasmacytoma.
  • Only 1 (6.3%) of 16 lymphoblastic B-cell lymphomas contained a BL-typical point mutation in the amino-terminal transactivation domain of Myc(His), suggesting that most of these tumors are derived from naive, pregerminal center B cells.
  • Twelve (46%) of 26 lymphoblastic B-cell lymphomas exhibited changes in the p19(Arf)-Mdm2-p53 tumor suppressor axis, an important pathway for Myc-dependent apoptosis.
  • We conclude that Myc(His) insertion into Igh predictably induces B-cell and plasma-cell tumors in mice, providing a valuable mouse model for understanding the transformation-inducing consequences of the MYC/Myc-activating endemic Burkitt lymphoma t(8;14)/plasmacytoma T(12;15) translocation.
  • [MeSH-major] Chromosomes, Human, Pair 14 / genetics. Chromosomes, Human, Pair 8 / genetics. Genes, myc / genetics. Immunoglobulin Heavy Chains / genetics. Lymphoma, B-Cell / genetics. Plasmacytoma / genetics. Translocation, Genetic / genetics
  • [MeSH-minor] Amino Acid Sequence. Animals. B-Lymphocytes / physiology. Burkitt Lymphoma / genetics. Burkitt Lymphoma / pathology. Disease Models, Animal. Genes, Tumor Suppressor / physiology. Humans. Mice. Molecular Sequence Data. Point Mutation. Precancerous Conditions / genetics. Precancerous Conditions / pathology. Promoter Regions, Genetic. Transgenes


9. Blach A, Zycinska-Debska E, Zon-Giebel A, Banas M, Kotulska A, Kucharz EJ: Seronegative arthritis in patient with solitary bone plasmacytoma. Clin Rheumatol; 2007 Jul;26(7):1167-8
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  • [Title] Seronegative arthritis in patient with solitary bone plasmacytoma.
  • We report a patient with localized focus of the bone destruction due to a rare disease, solitary bone plasmacytoma (SBP).
  • [MeSH-major] Arthritis / pathology. Bone Neoplasms / pathology. Plasmacytoma / pathology

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  • (PMID = 16609821.001).
  • [ISSN] 0770-3198
  • [Journal-full-title] Clinical rheumatology
  • [ISO-abbreviation] Clin. Rheumatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Antirheumatic Agents; 0 / Diphosphonates; 0 / Glucocorticoids; X4W7ZR7023 / Methylprednisolone
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10. Zhu H, Zhou XG: [Morphologic diversity of plasma cell neoplasms]. Zhonghua Bing Li Xue Za Zhi; 2010 Aug;39(8):528-31
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  • [Title] [Morphologic diversity of plasma cell neoplasms].
  • OBJECTIVE: To investigate the architectural and cytological variations of plasma cell neoplasms, and discuss the diagnosis and differential diagnosis.
  • METHODS: Histological and immunohistochemical examinations were used to study the morphologic and immunophenotypic features of 46 cases of plasma cell neoplasms.
  • 3 cases had a nestlike architecture that can mimic neuroendocrine tumors and 3 cases had a prominent fibrous sclerosis background.
  • Amyloid deposition, calcification or ossification and angiomatoid areas can be prominent and may obscure the neoplastic plasma cells.
  • Cytologically, 30 cases were composed of relatively mature plasma cells and can be recognized without too much difficulty.
  • Tumor cells resembled immunoblasts in 6 cases and small lymphocytes in 4 cases.
  • In another 2 cases tumor cells were easily confused with Signet-ring cells or clear cells.
  • Tumor cells were composed of anaplastic cells, histocytoid cells and spindle cells in each one case, respectively.
  • Lastly, tumor cells can be polymorphous which composed of multilobated, monocytoid or multinucleated cells in one case.
  • CONCLUSIONS: Except for the common architecture and cytology in plasma cell tumor, unusual morphology may appear.
  • Thus, pay attention to distinguish from lymphoma such as small lymphocytic lymphoma and anaplastic large cell lymphoma, pooly differentiated carcinoma, clear cell carcinoma or Signet-ring cell carcinoma, sarcoma, etc.
  • [MeSH-major] Bone Neoplasms / pathology. Mouth Neoplasms / pathology. Neoplasms, Plasma Cell / pathology. Nose Neoplasms / pathology. Plasmacytoma / pathology

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  • (PMID = 21055031.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD79; 0 / CD79A protein, human; 0 / Immunoglobulin kappa-Chains; 0 / Immunoglobulin lambda-Chains; 0 / Interferon Regulatory Factors; 0 / interferon regulatory factor-4; EC 3.2.2.5 / Antigens, CD38
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11. Hassen-Troudi F, Mege-Lechevallier F, Colombel M, Scoazec JY: [Testicular localisation of a plasmocytoma]. Ann Pathol; 2009 Feb;29(1):32-5
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  • [Title] [Testicular localisation of a plasmocytoma].
  • [Transliterated title] Localisation testiculaire d'un plasmocytome.
  • Testicular plasmocytomas are rare neoplasias that may occur as isolated tumors or in concomitance with a multiple myeloma.
  • We report the case of a 47-year-old man with previous history of multiple myeloma.
  • The histological examination showed a plasmocytoma and immunohistochemical stains revealed monoclonal light chain lambda in tumor cells.
  • [MeSH-major] Plasmacytoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 19233092.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Immunoglobulin Light Chains
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12. Bencheikh R, Benhammou A, Rabeh G, Benbouzid MA, Boulaich M, Essakali L, Kzadri M: [Solitary bony plasmocytoma of the mandible]. Rev Stomatol Chir Maxillofac; 2007 Apr;108(2):135-8
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  • [Title] [Solitary bony plasmocytoma of the mandible].
  • [Transliterated title] Plasmocytome solitaire osseux de la mandibule.
  • INTRODUCTION: Solitary plasmocytoma is a rare malignant tumor, belonging to the larger family of plasma cell proliferative diseases observed in bones.
  • Physical examination revealed a mandibular tumor with an osseous consistency covered by a healthy mucous.
  • Pathologic examination of the operative specimen demonstrated plasmocytoma.
  • Outcome at 13 months was favorable, without recurrence of multiple myeloma.
  • DISCUSSION: Plasma cell tumors are rare, about 10% of them are solitary plasmocytomas observed in intra- or extramedullar sites.
  • An exhaustive assessment is needed to rule out multiple myeloma.
  • Most solitary forms are observed in the spine.
  • Careful surveillance is required because of the frequent progression to multiple myeloma.
  • [MeSH-major] Mandibular Neoplasms / pathology. Plasmacytoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Multiple Myeloma / diagnosis. Radiography, Panoramic. Radiotherapy, Adjuvant. Tomography, X-Ray Computed

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  • (PMID = 17350056.001).
  • [ISSN] 0035-1768
  • [Journal-full-title] Revue de stomatologie et de chirurgie maxillo-faciale
  • [ISO-abbreviation] Rev Stomatol Chir Maxillofac
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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13. Dagan R, Morris CG, Kirwan J, Mendenhall WM: Solitary plasmacytoma. Am J Clin Oncol; 2009 Dec;32(6):612-7
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  • [Title] Solitary plasmacytoma.
  • PURPOSE: To analyze the outcomes of patients treated for solitary plasmacytoma with definitive radiotherapy (RT).
  • MATERIAL AND METHODS: Thirty-two patients with solitary plasmacytoma of bone (SPB; 22 patients) and extramedullary plasmacytoma (EMP; 10 patients) were treated between 1963 and 2006.
  • The 10-year multiple myeloma-free survival rates were: SPB, 30%; EMP, 90%; and overall, 50%.
  • Progression to multiple myeloma occurred at a median of 25.1 months after RT.
  • Patients with SPB are more likely to progress to multiple myeloma, which adversely affects their survival compared with those with EMP.
  • [MeSH-major] Bone Neoplasms / radiotherapy. Plasmacytoma / radiotherapy
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Male. Maximum Tolerated Dose. Middle Aged. Multiple Myeloma / pathology. Multiple Myeloma / radiotherapy. Prognosis. Survival Rate. Treatment Outcome

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  • (PMID = 19593082.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Mellor PJ, Polton GA, Brearley M, Haugland S, Smith KC, Scase TJ, McNeil PE, Holloway A, Archer J, Powell RM, Villiers EJ, Herrtage ME, Argyle DJ, Day MJ: Solitary plasmacytoma of bone in two successfully treated cats. J Feline Med Surg; 2007 Feb;9(1):72-7
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  • [Title] Solitary plasmacytoma of bone in two successfully treated cats.
  • This is the first report of feline solitary plasmacytoma of bone.
  • We describe the clinical, clinico-pathological, radiographic and pathological findings of two successfully treated cats with long-term follow-up.
  • A biopsy of L6 revealed neoplastic plasma cell infiltration.
  • Clinical signs resolved completely and 4 years after diagnosis the cat remains well and has no electrophoretically detectable paraproteinaemia.
  • A biopsy of sacral bone demonstrated neoplastic plasma cell infiltration.
  • The animal was normoglobulinaemic.
  • Cytological examination of a fine needle aspirate confirmed recurrence of plasma cell neoplasia.
  • Eighteen months into vincristine therapy, there was recurrence of clinical signs and the cat was euthanased, more than 6 years after the initial diagnosis.
  • [MeSH-major] Cat Diseases / diagnosis. Cat Diseases / therapy. Plasmacytoma / veterinary. Spinal Neoplasms / veterinary

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  • (PMID = 16887373.001).
  • [ISSN] 1098-612X
  • [Journal-full-title] Journal of feline medicine and surgery
  • [ISO-abbreviation] J. Feline Med. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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15. Fend F: [Molecular pathology of plasma cell neoplasms]. Pathologe; 2010 Oct;31 Suppl 2:188-92
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  • [Title] [Molecular pathology of plasma cell neoplasms].
  • Plasma cell myeloma (PCM) and related immunosecretory disorders are a group of B-cell proliferations with a wide clinical and prognostic spectrum, characterized by the production of monoclonal immunoglobulin by immortalized plasma cells.
  • Recent years have seen an explosion in knowledge on the genetic basis and biology of these diseases, followed by improved clinical risk stratification and the introduction of novel therapeutic concepts, such as treatment with proteasome inhibitors or immunomodulatory substances.
  • PCM is a common malignancy, accounting for approximately 10% of all hematological neoplasms.
  • There is good evidence to support a multistep transformation process in plasma cell neoplasms, which corresponds to clinically discernible disease stages.
  • Terminal disease stages are characterized by increasing genetic complexity and independence from bone marrow stromal cells and show a rapidly increasing tumour load with severe clinical symptoms.
  • Modern diagnostics of plasma cell neoplasms require inclusion of clinical, morphological, immunophenotypical and cytogenetic features to allow for individual risk assessment and therapy planning.
  • [MeSH-major] Neoplasms, Plasma Cell / genetics. Neoplasms, Plasma Cell / pathology
  • [MeSH-minor] Body Burden. Bone Marrow / pathology. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. DNA Mutational Analysis. Diagnosis, Differential. Disease Progression. Gene Expression Regulation, Neoplastic / genetics. Humans. In Situ Hybridization, Fluorescence. Neoplasm Staging. Paraproteinemias / genetics. Paraproteinemias / pathology. Plasmacytoma / genetics. Plasmacytoma / pathology. Risk Factors. Translocation, Genetic / genetics

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  • (PMID = 20852863.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
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16. Ketata W, Triki F, Msaad S, Ayadi L, Fouzi S, Ayadi H, Ayoub A: [A rare localization of solitary plasmocytoma]. Rev Pneumol Clin; 2009 Jun;65(3):165-8
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  • [Title] [A rare localization of solitary plasmocytoma].
  • [Transliterated title] Une localisation rare de plasmocytome solitaire.
  • INTRODUCTION: Solitary bone plasmocytoma is rare, characterized by malignant plasmocyte proliferation, derived from a sole B lymphocyte clone located on a bony segment without medullar invasion.
  • CASE REPORT: The authors report the case of a 60-year-old man who complained of dyspnea, dry cough, and thoracic pain four months before admission.
  • Surgical biopsy concluded as to the diagnosis of costal plasmocytoma.
  • All of the examinations carried out to search for other localizations were negative confirming the solitary nature of the tumor.
  • CONCLUSION: Solitary costal plasmocytoma should be called to mind when confronted with a lytic tumor of the rib.
  • The prognosis is dominated by the risk of progression to multiple myeloma.
  • [MeSH-major] Bone Neoplasms / pathology. Plasmacytoma / pathology. Ribs / pathology

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  • (PMID = 19524806.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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17. Pandit-Taskar N, Comenzo RL, Hassoun H, Hoover E, Borkar S, Reidel E, Cohen A, Surti C, Nimer SD, Landau HJ: FDG PET/CT (FDG PET) in evaluation of response in patients with multiple myeloma (MM) treated with bortezomib, pegylated liposomal doxorubicin, and dexamethasone. J Clin Oncol; 2009 May 20;27(15_suppl):8533
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  • [Title] FDG PET/CT (FDG PET) in evaluation of response in patients with multiple myeloma (MM) treated with bortezomib, pegylated liposomal doxorubicin, and dexamethasone.
  • METHODS: Forty pts with high-risk MM defined as ISS II, ISS III or presence of extramedullary plasmacytoma have been enrolled on study and treated using a combination of bortezomib, pegylated liposomal doxorubicin hydrochloride (Doxil), and dexamethasone (BDD) for 3 cycles followed by 2 cycles of thalidomide and dexamethasone for patients achieving at least PR.
  • MM disease response was assessed according to the International Myeloma Working Group (IMWG) criteria.
  • RESULTS: Median age of pts enrolled was 59 yrs (range 41-80), 62% male, 38% ISS II, 47% ISS III, and 15% ISS I with soft-tissue disease.
  • There was little agreement between MM disease response and FDG PET responses (Kappa statistic, 0.05).
  • One had granulomatous disease rather than MM at biopsy.
  • In 1 pt with progression of disease with a progressive skull-based plasmacytoma, FDG PET was scored as PR by EORTC criteria.
  • CONCLUSIONS: There was poor agreement between FDG PET response and MM disease response by IMWG criteria.

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  • (PMID = 27960928.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Bose P, Thompson CL, Gandhi DG, Ghabach BS, Ozer H: Response of AIDS-related plasmablastic lymphoma (PBL) to bortezomib. J Clin Oncol; 2009 May 20;27(15_suppl):e19562
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  • : e19562 PBL are a group of highly aggressive neoplasms originally described in the oral cavity and jaws of HIV-infected patients.
  • They are terminally differentiated B-cell neoplasms, and typically lack common B-cell markers but uniformly express plasma cell markers.
  • Flow cytometry was negative for CD45 and all common epithelial, T-cell and B-cell markers, but was positive for CD138 and p63(VS38c).
  • The diagnosis was stage IVBE PBL.
  • The WHO classifies PBL as a variant of diffuse large B-cell lymphoma.
  • However, studies of their immunophenotype and molecular histogenesis suggest that PBL are more closely related to plasma cell neoplasms.
  • Bortezomib is a proteasome inhibitor widely used in multiple myeloma and mantle cell lymphoma.
  • We chose bortezomib based on our patient's poor performance status and immune function, the desire to avoid combination chemotherapy, and translocations involving the immunoglobulin heavy chain gene locus (8;14) similar to those seen in multiple myeloma(4;14, 14;16) and mantle cell lymphoma(11;14).
  • A shift in the paradigm of treatment of PBL towards agents effective in plasma cell malignancies may be necessary.

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  • (PMID = 27961065.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Dhouib Sellami R, Sassi S, Mrad K, Abess I, Driss M, Ben Romdhane K: [Primary cutaneous plasmacytoma]. Ann Pathol; 2007 Apr;27(2):130-2
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  • [Title] [Primary cutaneous plasmacytoma].
  • [Transliterated title] Plasmocytome cutané primitif.
  • Primary cutaneous plasmacytoma (PCP) is a rare cutaneous B cell lymphoma.
  • Histologically, the lesion was composed predominately of variably maturated plasma cells with monotypic expression of lambda chain.
  • Extracutaneous localizations of the disease had been excluded.
  • The prognosis of PCP is better than that of the metastatic cutaneous lesion of myeloma.
  • The main prognosis factors are the size tumor and clinical presentation (solitary, versus multiple lesions).
  • Solitary lesions of the PCP are treated by surgical excision and sometimes local radiotherapy.
  • [MeSH-major] Plasmacytoma / pathology. Skin Neoplasms / pathology

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  • (PMID = 17909472.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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20. Fikri M, Semlali S, El Quessar A, El Hassani MR, Chakir N, Boukhrissi N, Jiddane M: [Kahler's disease presenting with a solitary cranial vault plasmacytoma]. Rev Neurol (Paris); 2006 Jun;162(6-7):757-9
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  • [Title] [Kahler's disease presenting with a solitary cranial vault plasmacytoma].
  • [Transliterated title] Maladie de Kahler révélée par un plasmocytome solitaire de la voûte.
  • INTRODUCTION: Solitary plasmocytoma is rarely located in the cranial vault.
  • We report the case of a 16-year-old patient presenting a cranial vault solitary plasmocytoma which revealed Kahler disease.
  • The cranio-encephalic radiography and the MRI showed a tumoral process involving cranial vault; biopsy revealed a solitary plasmocytoma.
  • Search for multiple myeloma was negative.
  • Six months later, a disease of Kahler was declared.
  • CONCLUSION: Clinical and biological follow-up of cranial plasmocytoma is necessary, because progression to multiple myeloma is possible as in our observation.
  • [MeSH-major] Plasmacytoma / pathology. Skull Neoplasms / pathology
  • [MeSH-minor] Adolescent. Combined Modality Therapy. Diagnosis, Differential. Diplopia / diagnosis. Diplopia / etiology. Humans. Magnetic Resonance Imaging. Male

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  • (PMID = 16840987.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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21. Wong CL, Mansberg R: Solitary plasmacytoma of bone: an unusual cause of severe sacral pain in a young man. Clin Nucl Med; 2005 Sep;30(9):612-4
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  • [Title] Solitary plasmacytoma of bone: an unusual cause of severe sacral pain in a young man.
  • An F-18 FDG PET study was performed for further assessment and clinical staging.
  • The mass demonstrated high glucose avidity consistent with a high-grade tumor.
  • Histologic examination confirmed the lesion to be a plasmacytoma.
  • Solitary plasmacytoma of bone occurs predominantly in older patients involving the axial skeleton.
  • [MeSH-major] Arthralgia / etiology. Arthralgia / radionuclide imaging. Bone Neoplasms / radionuclide imaging. Low Back Pain / etiology. Plasmacytoma / radionuclide imaging. Sacroiliac Joint / radionuclide imaging. Sacrum / radionuclide imaging

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  • (PMID = 16100481.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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22. Janz S: Myc translocations in B cell and plasma cell neoplasms. DNA Repair (Amst); 2006 Sep 8;5(9-10):1213-24
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Myc translocations in B cell and plasma cell neoplasms.
  • Chromosomal translocations that join the cellular oncogene Myc (c-myc) with immunoglobulin (Ig) heavy-chain (Igh) or light-chain (Igk, Igl) loci are widely believed to be the crucial initiating oncogenic events in the development of B cell and plasma cell neoplasms in three mammalian species: Burkitt lymphoma (BL) in human beings, plasmacytoma (PCT) in mice, and immunocytoma in rats.
  • Among the Myc-Ig translocations found in these neoplasms, mouse PCT T(12;15)(Igh-Myc) is of special interest because it affords a uniquely useful model system to study the fundamental outstanding questions on the mechanisms, genetics, and biological consequences of Myc translocations.
  • Mouse T(12;15) is the only cancer-associated translocation in mice that occurs with high incidence, spontaneity, and cell-type specificity.
  • The molecular pathway that subverts CSR to mediate trans-chromosomal joining of Myc and Smu (translocation origin) and secondary modification of Myc-Igh junctions (translocation "remodeling") has not been elucidated, but recent evidence indicates that it includes CSR factors, such as the activation-induced cytidine deaminase (AID), that may also be involved in the ongoing neoplastic progression of the translocation-bearing tumor precursor.
  • Transgenic mouse models of T(12;15)/t(8;14), including newly developed "iMyc" gene-insertion mice, will be useful in elucidating the role of these CSR factors in the progression of Myc-induced B cell tumors.
  • [MeSH-major] Genes, myc. Lymphoma, B-Cell / genetics. Models, Genetic. Plasmacytoma / genetics. Translocation, Genetic
  • [MeSH-minor] Animals. Chromosome Breakage. Disease Models, Animal. Genes, Immunoglobulin Heavy Chain. Humans. Immunoglobulin Class Switching. Mice. Mice, Inbred BALB C. Mice, Transgenic. Polymerase Chain Reaction

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  • (PMID = 16815105.001).
  • [ISSN] 1568-7864
  • [Journal-full-title] DNA repair
  • [ISO-abbreviation] DNA Repair (Amst.)
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 117
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23. Singh AD, Chacko AG, Chacko G, Rajshekhar V: Plasma cell tumors of the skull. Surg Neurol; 2005 Nov;64(5):434-8; discussion 438-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plasma cell tumors of the skull.
  • BACKGROUND: Plasma cell tumors are rare neoplasms, which include extramedullary plasmacytoma, solitary plasmacytoma of the bone, and multiple myeloma.
  • METHODS: This study was conducted by retrospective chart review and correspondence with patients diagnosed to have plasma cell tumors of the skull from 1992 to 2004.
  • RESULTS: We report 5 cases of plasma cell tumors of the skull.
  • In 2 cases, the histopathology was reported as plasmacytoma and further investigations revealed systemic involvement, indicative of multiple myeloma.
  • In 1 patient, the biopsy was reported as multiple myeloma.
  • Another patient with a scalp swelling and symptoms of systemic involvement underwent investigations to detect multiple myeloma and, hence, was not subjected to an invasive procedure for histopathologic diagnosis.
  • The last patient in our series died in the immediate postoperative period and although her histopathology was reported as plasmacytoma, she could not be evaluated for systemic involvement.
  • CONCLUSION: The treatment options are different for the systemic form of disease and the localized disease; hence, it is imperative that a rigorous search for systemic involvement is conducted in a case of solitary or extramedullary plasmacytoma.
  • [MeSH-major] Plasmacytoma / pathology. Plasmacytoma / surgery. Skull Neoplasms / pathology. Skull Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Biopsy. Combined Modality Therapy. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Prognosis. Retrospective Studies

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  • (PMID = 16253694.001).
  • [ISSN] 0090-3019
  • [Journal-full-title] Surgical neurology
  • [ISO-abbreviation] Surg Neurol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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24. Nasr Ben Ammar C, Ghorbel I, Kochbati L, Gargouri W, Touati S, Maalej M: [Solitary and extramedullary plasmocytoma in the head and neck region: five cases report]. Cancer Radiother; 2010 Dec;14(8):755-8
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  • [Title] [Solitary and extramedullary plasmocytoma in the head and neck region: five cases report].
  • [Transliterated title] Plasmocytome solitaire extramédullaire de la tête et du cou: à propos de cinq cas.
  • PURPOSE: To assess the outcome and the management of solitary extramedullary plasmocytoma in the head and neck region.
  • PATIENTS AND METHODS: From 1997 to 2008, five cases of solitary extramedullary plasmocytoma were treated in the department of radiotherapy at Salah-Azaiz Institute.
  • Three patients had a solitary plasmocytoma of the nasal fossa; the others were ethmoidal and submandibular node.
  • Multiple myeloma occurred in one patient 8 years after treatment.
  • Local control of extramedullary plasmocytoma in the head and neck region seems to be improved when the dose is at least 45 Gy.
  • Predictive parameters of unfavourable outcome and conversion of extramedullary plasmocytoma to multiple myeloma should be better defined.
  • [MeSH-major] Head and Neck Neoplasms / radiotherapy. Plasmacytoma / radiotherapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Disease Progression. Ethmoid Bone / pathology. Ethmoid Bone / surgery. Female. Humans. Male. Maxillary Neoplasms / pathology. Maxillary Neoplasms / radiotherapy. Maxillary Neoplasms / surgery. Middle Aged. Multiple Myeloma / drug therapy. Multiple Myeloma / radiotherapy. Neoplasm Invasiveness. Neoplasm Recurrence, Local / radiotherapy. Nose Neoplasms / radiotherapy. Nose Neoplasms / surgery. Remission Induction. Skull Neoplasms / pathology. Skull Neoplasms / radiotherapy. Skull Neoplasms / surgery. Treatment Outcome

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  • [Copyright] Copyright © 2010 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.
  • (PMID = 20673736.001).
  • [ISSN] 1769-6658
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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25. Chua SC, O'Connor SR, Wong WL, Ganatra RH: Case report: Solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature. Br J Radiol; 2008 Apr;81(964):e110-4
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  • [Title] Case report: Solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature.
  • We describe a case of oncogenic osteomalacia secondary to solitary plasmacytoma of the vertebral body of T3.
  • Following the initial diagnosis, the lesion was surgically resected with good results, although several follow-up procedures, including bone grafting, were necessary to stabilize the thoracic spine.
  • The lesion recurred almost 15 years after its initial resection, again presenting with hypophosphataemia and neurological symptoms suggestive of local tumour recurrence.
  • A variety of radiological examinations were performed in an attempt to confirm and localize recurrent tumour, including bone scintigraphy, (111)indium octreotide scintigraphy, high-resolution CT and MRI of the thoracic spine, but these yielded only negative or equivocal results owing, in part, to the presence of extensive post-operative changes, and also to a difference in the MR signals of the recurrent and original tumours.
  • Positron emission tomography (PET/CT) demonstrated a solitary focus of intense fluorodeoxyglucose uptake in the T3 vertebral body, enabling a definitive diagnosis of recurrent plasmacytoma.
  • This case illustrates the diagnostic value of PET/CT in the setting of challenging post-operative changes in the surrounding tissue and in the appearance of the tumour itself.
  • [MeSH-major] Bone Neoplasms / diagnosis. Neoplasm Recurrence, Local / diagnosis. Plasmacytoma / diagnosis. Positron-Emission Tomography

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  • (PMID = 18344267.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Indium Radioisotopes; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 39
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26. Voulgaris S, Partheni M, Gousias K, Polyzoidis K, Konstantinou D: Solitary plasmacytoma of the upper cervical spine: therapeutic considerations. J Neurosurg Sci; 2008 Jun;52(2):55-9
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  • [Title] Solitary plasmacytoma of the upper cervical spine: therapeutic considerations.
  • Solitary plasmacytomas are localized plasma cell malignancies involving bone marrow (solitary bone plasmacytoma, SBP) or extramedullary tissues (solitary extramedullary plasmacytoma, SEP).
  • The authors describe a patient with solitary plasmacytoma involving all the elements of C2 vertebra.
  • Severe neck pain was the only manifestation of disease.
  • The authors stress the importance of early diagnosis followed by appropriate multidisciplinary treatment strategies, including surgery and discuss the management dilemmas concerning the timing and management consequence, in scope to prevent a major neurological damage and allow the patient to be ambulatory.
  • [MeSH-major] Plasmacytoma / surgery. Spinal Neoplasms / surgery

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  • (PMID = 18500219.001).
  • [ISSN] 0390-5616
  • [Journal-full-title] Journal of neurosurgical sciences
  • [ISO-abbreviation] J Neurosurg Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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27. Chang ST, Liao YL, Lu CL, Chuang SS, Li CY: Plasmablastic cytomorphologic features in plasma cell neoplasms in immunocompetent patients are significantly associated with EBV. Am J Clin Pathol; 2007 Aug;128(2):339-44
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  • [Title] Plasmablastic cytomorphologic features in plasma cell neoplasms in immunocompetent patients are significantly associated with EBV.
  • Multiple myeloma (MM) is rarely associated with Epstein-Barr virus (EBV) irrespective of HIV status, in contrast with its morphologic mimic, plasmablastic lymphoma, which occurs mainly in immunocompromised patients with frequent EBV association.
  • Among 58 consecutive immunocompetent patients, we found plasmablastic cytomorphologic features in 2 of 4 with plasmacytomas and 14 (26%) of 54 with MM.
  • Of the tumors, 4 (7%; 1 plasmacytoma and 3 MMs) were EBV-encoded RNA (EBER)-positive with plasmablastic cytomorphologic features in 3.
  • The patient with plasmacytoma was disease free for 75 months, and the remaining 3 patients with MM died at 15, 74, and 97 months, respectively; the median survival of patients with EBER- MM was 12 months.
  • EBV+ tumors were associated with plasmablastic cytomorphologic features and high labeling indices.
  • Rare EBER+ plasmablastic plasma cell tumors exist in immunocompetent patients.
  • These tumors may have been driven by EBV to gain the plasmablastic cytomorphologic features and high proliferation fraction.
  • [MeSH-major] Herpesvirus 4, Human / isolation & purification. Multiple Myeloma / pathology. Plasmacytoma / pathology

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  • (PMID = 17638671.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA, Viral
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28. Bousnina S, Zendah I, Marniche K, Yalaoui S, El Mezni F, Megdiche ML, Chabbou A: [Solitary plasmocytoma of the rib: a rare tumor not to miss]. Rev Pneumol Clin; 2006 Sep;62(4):243-6
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  • [Title] [Solitary plasmocytoma of the rib: a rare tumor not to miss].
  • [Transliterated title] Plasmocytome solitaire à localisation costale: une tumeur rare à ne pas méconnaître.
  • Solitary plasmocytoma is a rare tumor accounting for 5% of all plasma cell neoplasias.
  • The diagnosis is based on identification of the localized tumor composed of monoclonal plasma cells identical to those observed in multiple myeloma, and absence of the signs in favor of a disseminated form.
  • Surgical biopsy for pathology study and immunohistochemistry enabled the diagnosis of costal plasmocytoma.
  • Search for other localizations was negative and the diagnosis of solitary plasmocytoma was retained.
  • Costal localization is rare for solitary plasmocytoma.
  • The diagnosis is based on imaging findings and pathology.
  • Radiotherapy is the treatment of choice but with the risk of progression with other bone lesions, the development of medullary plasmocytosis and multiple myeloma.
  • [MeSH-major] Bone Neoplasms / diagnosis. Plasmacytoma / diagnosis. Ribs

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  • (PMID = 17075549.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Immunoglobulin kappa-Chains
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29. Anil S: Solitary plasmacytoma of the maxilla--a case report and review of the literature. Gen Dent; 2007 Jan-Feb;55(1):39-43
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  • [Title] Solitary plasmacytoma of the maxilla--a case report and review of the literature.
  • Plasma cell neoplasms have been classified as multiple myeloma, solitary plasmacytoma, and extramedullary plasmacytoma.
  • The solitary plasmacytoma of the maxilla is a rare condition that focuses solely on myelomatous tissue and is not disseminated to other parts of the skeleton.
  • The dense plasma cell infiltration that commonly is associated with inflammatory lesions within the oral tissues makes diagnosing plasmacytoma at this site problematic.
  • This article presents a case of solitary plasmacytoma in the maxilla.
  • Radiographic examination revealed an osteolytic lesion over the right maxillary bone, invading the maxillary sinus.
  • A CT scan showed that the tumor mass occupied the right maxillary sinus and the lateral wall of the nasal cavity.
  • The tumor cells were composed of densely packed, round, polygonal cell structures that were scattered in relatively sparse stoma.
  • The neoplastic cells had a large, single eccentric nucleus, resembling typical plasma cells.
  • The clinical, histopathological, and radiological features of solitary plasmacytoma are discussed.
  • [MeSH-major] Maxillary Neoplasms / pathology. Maxillary Sinus Neoplasms / pathology. Palatal Neoplasms / pathology. Plasmacytoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Male. Middle Aged. Neoplasm Invasiveness. Tomography, X-Ray Computed

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  • (PMID = 17333965.001).
  • [ISSN] 0363-6771
  • [Journal-full-title] General dentistry
  • [ISO-abbreviation] Gen Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 36
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30. Nolan KD, Mone MC, Nelson EW: Plasma cell neoplasms. Review of disease progression and report of a new variant. Surg Oncol; 2005 Aug;14(2):85-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plasma cell neoplasms. Review of disease progression and report of a new variant.
  • Plasma cell neoplasms are generally categorized into four groups; multiple myeloma (MM), solitary plasmacytoma of the bone (SPB), plasma cell leukemias, and extramedullary plasmacytomas (EMP).
  • A plasmacytoma is defined as any discrete, usually solitary mass of neoplastic plasma cells, either in the bone marrow or in various soft tissue sites.
  • Each manifestation of a plasma cell neoplasm differs in terms of tumor recurrence and progression to MM.
  • A gastric plasmacytoma (GP) is a rare presentation of extramedullary plasmacytoma and has not been previously reported as a site of recurrence for a SPB.
  • This pattern of tumor recurrence is unique and the management of gastric plasmacytoma as part of this complex disease is discussed.
  • The continuum of progression between various sites and manifestations of plasma cell manifestations is reviewed including a previously undiscovered sequence of bone disease, gastric disease, and finally multiple myeloma.
  • [MeSH-major] Bone Neoplasms / physiopathology. Multiple Myeloma / physiopathology. Plasmacytoma / physiopathology. Stomach Neoplasms / physiopathology
  • [MeSH-minor] Aged. Antineoplastic Agents / therapeutic use. Disease Progression. Gastrectomy. Humans. Male. Orthopedic Procedures. Radiotherapy

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  • (PMID = 15993050.001).
  • [ISSN] 0960-7404
  • [Journal-full-title] Surgical oncology
  • [ISO-abbreviation] Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 24
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31. Lesmes D, Laster Z: Plasmacytoma in the temporomandibular joint: a case report. Br J Oral Maxillofac Surg; 2008 Jun;46(4):322-4
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  • [Title] Plasmacytoma in the temporomandibular joint: a case report.
  • We report a case of a 64-year-old patient in whom limitation of mouth opening was the presenting symptom of plasmacytoma.
  • Intra-oral biopsy confirmed a plasma-cell tumour, with no sign of extension on imaging.
  • The diagnosis of solitary plasmacytoma of bone can be confirmed only when the presence of systemic disease has been excluded by clinical, biological, and radiological investigations.
  • Long-term follow-up is necessary because of the high risk of development of multiple myeloma, which may be delayed.
  • [MeSH-major] Plasmacytoma / pathology. Temporomandibular Joint Disorders / pathology

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  • (PMID = 17698264.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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32. Zuo Z, Liu WP, Tang Y, Bi CF, Wang XQ, Zhang WY, Yang QP, Zou LQ: [Solitary plasmacytoma of bone: a clinicopathologic, immunohistochemical and immunoglobulin gene rearrangement study]. Zhonghua Bing Li Xue Za Zhi; 2010 Mar;39(3):177-82
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  • [Title] [Solitary plasmacytoma of bone: a clinicopathologic, immunohistochemical and immunoglobulin gene rearrangement study].
  • OBJECTIVE: To investigate clinicopathologic features of solitary plasmacytoma of bone (SPB) and the role of immuno-phenotype and immunoglobulin gene rearrangement detection in the diagnosis and differential diagnosis of SPB.
  • Low serum level of M-components was found in 5 cases, including two of IgG type (21.4 g/L) and three of IgA type.
  • Clinical manifestations were closely related to the anatomic sites involved, such as pain due to bone destruction, symptoms and signs caused by compression of spinal cord or nerve root, and pathological fracture.
  • All cases presented as a solitary osteolytic lesion.
  • According to the histological grading criteria, grade I tumor was seen in 12 of 21 cases (57.1%).
  • Immunohistochemically, the neoplastic cells expressed two or more plasma cell antigens, including CD138, CD38 and PC, but no CD19 and CD20.
  • Three patients developed multiple myeloma (MM) and died of the tumor.
  • CONCLUSIONS: SPB is a rare tumor with bone pain as the most common presenting symptom due to bone destruction.
  • The diagnosis of EMP can only be established after exclusion of an extramedullay invasion by MM.
  • Immunophenotype and IgH gene rearrangement analysis play important roles in the diagnosis of SPB.
  • [MeSH-major] Bone Neoplasms / pathology. Gene Rearrangement, B-Lymphocyte, Heavy Chain. Plasmacytoma / pathology. Syndecan-1 / metabolism
  • [MeSH-minor] Adult. Aged. Antigens, CD38 / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunophenotyping. Lymphoma, Large B-Cell, Diffuse / metabolism. Lymphoma, Large B-Cell, Diffuse / pathology. Lymphoma, Large-Cell, Anaplastic / metabolism. Lymphoma, Large-Cell, Anaplastic / pathology. Male. Melanoma / metabolism. Melanoma / pathology. Middle Aged. Multiple Myeloma / pathology. Retrospective Studies. Survival Rate

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  • (PMID = 20450765.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Syndecan-1; EC 3.2.2.5 / Antigens, CD38
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33. Alvarez-Múgica M, Jalón Monzón A, Bulnes Vázquez V, Aguilar Andrea C, Fernández Gómez JM, González Alvarez RC, Regadera Sejas FJ: Secondary testicular plasmocytoma. Arch Esp Urol; 2007 Jan-Feb;60(1):99-102
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  • [Title] Secondary testicular plasmocytoma.
  • OBJECTIVE: [corrected] To report a rare case of secondary testicular plasmocytoma in the context of a testicular mass.
  • METHOD: We introduced a patient with plasmocytoma and a testicular infiltration of his systemic affection.
  • CONCLUSIONS: Plasmacytoma is a plasma cell tumor that involves bone marrow or extramedullary sites.
  • Testicular infiltration by plasma cells such as plasmacytoma happens in only 2% of cases of all plasma cell neoplasm
  • [MeSH-major] Cervical Vertebrae. Plasmacytoma / secondary. Spinal Neoplasms / pathology. Testicular Neoplasms / secondary

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  • (PMID = 17408185.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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34. Richendollar BG, Hsi ED, Cook JR: Extramedullary plasmacytoma-like posttransplantation lymphoproliferative disorders: clinical and pathologic features. Am J Clin Pathol; 2009 Oct;132(4):581-8
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  • [Title] Extramedullary plasmacytoma-like posttransplantation lymphoproliferative disorders: clinical and pathologic features.
  • Most monomorphic posttransplantation lymphoproliferative disorders (PTLDs) resemble diffuse large B-cell lymphoma or Burkitt lymphoma.
  • Rare cases of PTLD resembling extramedullary plasmacytomas have also been described.
  • This report describes the clinical, histologic, phenotypic, and genotypic findings in 4 cases of plasmacytoma-like PTLD (2 nodal, 1 adenoidal, and 1 cutaneous) and compares the findings with extramedullary involvement by plasma cell neoplasms arising in immunocompetent patients.
  • Plasmacytoma-like PTLDs characteristically arise late after transplantation (mean, 7.0 years), show a variable association with Epstein-Barr virus (2/4 cases positive), and demonstrate histologic and phenotypic findings that overlap with immunocompetent extramedullary plasma cell neoplasms.
  • None of the patients with plasmacytoma-like PTLD developed lytic bone lesions, and 3 of 4 patients had complete responses (>2 years) to reduction of immunosuppression, confirming the role of immunosuppression in the pathogenesis of these lesions.
  • This report, which represents the first case series of plasmacytoma-like PTLD, clarifies the features of this rare subtype of PTLD.
  • [MeSH-major] Heart Transplantation / adverse effects. Immunosuppression / adverse effects. Kidney Transplantation / adverse effects. Liver Transplantation / adverse effects. Myeloproliferative Disorders / etiology. Plasmacytoma / etiology


35. Pratibha CB, Sreenivas V, Babu MK, Rout P, Nayar RC: Plasmacytoma of larynx--a case report. J Voice; 2009 Nov;23(6):735-8
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  • [Title] Plasmacytoma of larynx--a case report.
  • Plasma cell myeloma, the most common plasma cell neoplasm, is characterized by the presence of multiple lesions in the bone marrow.
  • A single isolated lesion may occur either in bone (solitary plasmacytoma of bone) or in soft tissue (extramedullary plasmacytoma).
  • Most cases of extramedullary plasmacytoma occur in the head and neck region.
  • The diagnosis is established by histopathology and immunohistochemistry.
  • A detailed evaluation for lesions at other sites is recommended as extramedullary plasmacytoma treated by radiation therapy has better survival rates than plasma cell myeloma, which is treated by chemotherapy.
  • A case of plasmacytoma of the larynx is presented highlighting clinical and histological features with a review of literature.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Plasmacytoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Follow-Up Studies. Humans. Immunohistochemistry. Laryngoscopy. Larynx / pathology. Male. Middle Aged. Treatment Outcome. Vocal Cords / pathology

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  • (PMID = 18619786.001).
  • [ISSN] 1873-4588
  • [Journal-full-title] Journal of voice : official journal of the Voice Foundation
  • [ISO-abbreviation] J Voice
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 19
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36. Ghanem N, Lohrmann C, Engelhardt M, Pache G, Uhl M, Saueressig U, Kotter E, Langer M: Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal survey. Eur Radiol; 2006 May;16(5):1005-14
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  • [Title] Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal survey.
  • To compare the diagnostic value of whole-body MRI versus radiological skeletal survey (RSS) in staging patients with plasma cell neoplasms (PCN) and to evaluate the possible therapeutic impact of the replacement of RSS by whole-body MRI.
  • Fifty-four patients with PCN [multiple myeloma (MM), n=47; monoclonal gammopathy of unknown significance (MGUS), n=7] were studied by whole-body MRI and RSS in a monocenter prospective analysis from August 2002 to May 2004.
  • Bone involvement was observed in 30/54 (55%) patients; however, whole-body MRI revealed this more extensively than the RSS in 27/30 (90%) patients with concordant positive imaging findings.
  • In 3/30 (10%) patients, both imaging techniques demonstrated a similar extent of bone marrow infiltration.
  • In 10/54 (19%) patients, the whole-body MRI was superior to RSS in detecting bone marrow infiltration, whereas the RSS was negative.
  • In 3/54 (6%) patients, the RSS was proven to be false positive by the clinical course, whereas the whole-body MRI was truly negative.
  • Whole-body MRI is a fast and highly effective method for staging PCN patients by the use of a rolling table platform.
  • Moreover, it is more sensitive and specific than RSS and reveals bone marrow infiltration and extensive disease more reliably.
  • [MeSH-major] Bone Marrow Neoplasms / secondary. Bone and Bones / pathology. Magnetic Resonance Imaging. Multiple Myeloma / secondary. Whole Body Imaging

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  • (PMID = 16463030.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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37. Rafai MA, Fadel H, Boulaajaj FZ, Sibai M, Rafai M, El Moutawakkil B, Bourezgui M, Trafeh M, Slassi I: [POEMS syndrome with plasmocytoma lytic bone lesion]. Rev Neurol (Paris); 2008 Aug-Sep;164(8-9):722-7
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  • [Title] [POEMS syndrome with plasmocytoma lytic bone lesion].
  • [Transliterated title] POEMS syndrome avec plasmocytome ostéolytique.
  • Further explorations revealed skin lesions with glomeruloid angiomas, edematous vasomotor disorders as well as erythrocyanose, hypogonadism, papillar edema and a lytic bone lesion of the left scapula.
  • Radiotherapy was associated with corticosteroids and plasma exchanges.
  • DISCUSSION: POEMS syndrome is rare; the diagnosis is based on necessary criteria, the presence of a demyelinating and axonal polyneuropathy associated with an IgA or IgG monoclonal gammapathy, the light chain being almost entirely lambda, associated to other characteristic elements, in particular glomeruloid angiomas, endocrinopathy, sclerosing plasmocytoma which must be carefully required.
  • Treatment is based on surgical cure or radiotherapy for bone lesion and non specific treatments such as corticosteroid therapy, plasma exchanges and IVIG.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / pathology. POEMS Syndrome / complications. POEMS Syndrome / pathology. Plasmacytoma / complications. Plasmacytoma / pathology

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  • (PMID = 18805304.001).
  • [ISSN] 0035-3787
  • [Journal-full-title] Revue neurologique
  • [ISO-abbreviation] Rev. Neurol. (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Immunoglobulin G; 0 / Steroids
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38. Kremer M, Ott G, Nathrath M, Specht K, Stecker K, Alexiou C, Quintanilla-Martinez L, Fend F: Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol; 2005 Jan;205(1):92-101
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  • [Title] Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis.
  • Primary extramedullary plasmacytomas are infrequent, typically solitary, plasma cell neoplasms that generally pursue an indolent clinical course but may, rarely, convert to multiple myeloma.
  • Twenty-eight cases of primary extramedullary plasmacytoma and 26 cases of both medullary (n = 17) and extramedullary (n = 9) multiple myeloma were analysed for the expression of proteins known to play a role in the biology of multiple myeloma.
  • Twenty-three extramedullary plasmacytomas were localized in the upper aerodigestive tract, four in the lymph nodes, and one in the testis.
  • None of the patients died from the disease or progressed to multiple myeloma (mean follow-up 50 months).
  • Nine patients developed local relapse and one patient's tumour evolved into a B-cell non-Hodgkin's lymphoma.
  • In contrast to both intra- and extra-medullary multiple myeloma, extramedullary plasmacytoma showed absence of cyclin D1 (p < 0.001) and infrequent expression of CD56 (p < 0.001).
  • Furthermore, extramedullary plasmacytomas were characterized by weaker staining for Bcl-2 protein and rare overexpression of p21 and p53.
  • In comparison to extramedullary multiple myeloma, extramedullary plasmacytoma showed a more mature morphology and lower proliferation indices (p = 0.008).
  • There was no association between the phenotypic parameters investigated and clinical outcome in extramedullary plasmacytoma.
  • In summary, extramedullary plasmacytoma and multiple myeloma show significant immunophenotypic differences, some of which may be of both diagnostic utility and biological relevance.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Multiple Myeloma / metabolism. Neoplasm Proteins / metabolism. Plasmacytoma / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Antigens, CD56 / metabolism. Cyclin D1 / metabolism. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Immunophenotyping. Male. Middle Aged. Neoplasm Staging. RNA, Messenger / genetics. RNA, Neoplasm / genetics. Retrospective Studies


39. Salarieh A, Rao C, Gottesman SR, Alagha O, Todor R, Axiotis CA: Plasma cell tumors in HIV-positive patients: report of a case and review of the literature. Leuk Lymphoma; 2005 Jul;46(7):1067-74
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  • [Title] Plasma cell tumors in HIV-positive patients: report of a case and review of the literature.
  • Plasma cell tumors show an increased incidence in HIV-positive patients.
  • The cases reported in the literature suggest that plasma cell tumors occur in a younger age group than that encountered in the general population.
  • Pathologically, many of these tumors show a plasmablastic morphology.
  • Plasma cell tumors in HIV-positive patients may present at unusual sites and progress rapidly to involve multiple sites, including the soft tissues and viscera.
  • A case of plasma cell tumor in an HIV-positive patient is presented.
  • [MeSH-major] Brain Neoplasms / complications. HIV Seropositivity / complications. Plasmacytoma / complications


40. Alvarez-Twose I, Vano-Galvan S, Calvo-Villas JM, Carreter E, Piqué E, Palacios S: Metastatic cutaneous plasmacytoma presenting as a perianal giant mass. Dermatol Online J; 2008;14(9):17
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  • [Title] Metastatic cutaneous plasmacytoma presenting as a perianal giant mass.
  • There are 4 types of plasma-cell neoplasia: classic multiple myeloma (MM), extramedullary plasmacytoma without MM, solitary plasmacytoma of bone, and plasma-cell leukemia.
  • Cutaneous involvement may be seen in all 4 types of plasma-cell neoplasia.
  • It usually occurs in late stages of MM as a reflection of increased tumor cell burden.
  • Extramedullary plasmacytoma (EMP) of the skin is a well-recognized, extremely rare, occurrence in MM.
  • Extramedullary plasmacytomas of the skin can be divided into primary cutaneous plasmacytoma (PCP) and metastatic cutaneous plasmacytoma (MCP).
  • Primary cutaneous plasmacytoma is defined as monoclonal proliferation of plasma-cells that arises primarily in the skin without evidence of systemic disease.
  • In contrast to PCP, MCP arises from lymphatic or vascular spread of tumour or, more frequently, by direct extension from underlying bone lesions.
  • [MeSH-major] Anus Neoplasms / secondary. Multiple Myeloma / pathology. Plasmacytoma / secondary. Skin Neoplasms / secondary

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  • (PMID = 19061599.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] United States
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; VAD protocol
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41. Romero IL, Campos FA, Damasceno RW, Vital Filho J, Bison SH: Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report. Arq Bras Oftalmol; 2009 Mar-Apr;72(2):236-8
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  • [Title] Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report.
  • The authors present a rare case of plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma in a 42-year-old woman.
  • However, no abnormality was observed on serum electrophoresis, skeletal survey and bone marrow aspiration.
  • Therefore, the tumor was diagnosed solitary plasmacytoma of bone.
  • The patient was treated with external beam radiotherapy and has remained disease free for 5 years and 6 months until 2007, when she presented a pathological fracture due to multiple myeloma.
  • Extensive medical work-up to rule out multiple myeloma or other malignant lymphoproliferative conditions involving orbit or ocular adnexa is needed when the diagnosis of solitary plasmacytoma of bone is suspected because treatment and prognosis are very different.
  • [MeSH-major] Eye Neoplasms / diagnosis. Multiple Myeloma / pathology. Orbital Neoplasms / diagnosis. Plasmacytoma / diagnosis

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  • (PMID = 19466336.001).
  • [ISSN] 1678-2925
  • [Journal-full-title] Arquivos brasileiros de oftalmologia
  • [ISO-abbreviation] Arq Bras Oftalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Immunoglobulin G
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42. Khaliq W, Uzoaru I, Konchanin RP, Sapiente RA, Egner JR: Solitary extramedullary plasmacytoma of the bladder: a case report and literature. Oncology (Williston Park); 2010 Aug;24(9):832-5
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  • [Title] Solitary extramedullary plasmacytoma of the bladder: a case report and literature.
  • Plasmacytoma is a rare B-lymphocyte neoplastic disorder that usually presents as the generalized disease multiple myeloma.
  • Less than 5% of the cases present as a solitary mass of monoclonal plasma cells in the bone or soft tissue.
  • Although solitary extramedullary plasmacytoma (SEP) may arise in any organ, it rarely involves the urinary bladder.
  • A 67-year-old male without a history of multiple myeloma presented with urinary frequency and nocturia; he was later diagnosed with SEP of the bladder.
  • SEP usually carries a better prognosis and higher cure rate than solitary plasmacytoma of bone, as SEP is radiation sensitive.
  • The literature also lacks recommendations for choice of a chemotherapy regimen and surveillance of isolated bladder plasmacytoma.
  • Here we present the first case of a radiation-resistant solitary plasmacytoma of the bladder that was successfully treated with lenalidomide and dexamethasone with successful clinical remission.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols. Plasmacytoma. Radiotherapy. Urinary Bladder Neoplasms

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  • [CommentIn] Oncology (Williston Park). 2010 Aug;24(9):836 [20923038.001]
  • [CommentIn] Oncology (Williston Park). 2010 Aug;24(9):838 [20923039.001]
  • (PMID = 20923037.001).
  • [ISSN] 0890-9091
  • [Journal-full-title] Oncology (Williston Park, N.Y.)
  • [ISO-abbreviation] Oncology (Williston Park, N.Y.)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 4Z8R6ORS6L / Thalidomide; 7S5I7G3JQL / Dexamethasone; F0P408N6V4 / lenalidomide
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43. Huang W, Cao D, Ma J, Yang X, Xiao J, Zheng W, Feng D, Wu Z, Huang Q, Chen D, Jia L: Solitary plasmacytoma of cervical spine: treatment and prognosis in patients with neurological lesions and spinal instability. Spine (Phila Pa 1976); 2010 Apr 15;35(8):E278-84
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  • [Title] Solitary plasmacytoma of cervical spine: treatment and prognosis in patients with neurological lesions and spinal instability.
  • STUDY DESIGN: A consecutive series of 19 cases of solitary plasmacytoma (SP) of cervical spine that underwent surgical treatment and one case that underwent pure radiotherapy were observed from 1995 to 2006.
  • OBJECTIVE: To discuss the clinical characteristics, therapeutic methods and factors affecting prognosis of SP in the cervical spine.
  • SUMMARY OF BACKGROUND DATA: SP of bone is a rare plasma cell tumor which represents the proliferation of monoclonal plasma cells without evidence of significant bone marrow plasma cell infiltration.
  • Although radical radiotherapy is the treatment of choice for SP of the bone, recommendations for treatment methods of this disease have been solely based on limited data from retrospective studies.
  • Reconstruction of the cervical spine was achieved through an anterior cervical titanium plate and titanium mesh cage filled with autoiliac graft or bone cement, or anterior and posterior combined instrumented fusion.
  • The bone graft fusion rate reached 100%.
  • During the follow-up period, 4 surgery cases progressed to multiple myeloma (MM), in which 2 elderly patients died of respiratory and circulatory failure at 90 and 43 months, respectively.
  • The other 15 patients achieved disease-free survival after surgery with adjunctive radiotherapy.
  • No significant abnormality was detected on M protein, bone marrow aspiration, and emission computed tomography or positron emission tomography/computed tomography examinations.
  • Gross total tumor resection or total spondylectomy by piecemeal manner with adjuvant radiotherapy can markedly reduce local recurrences and lower the possibility of progressing to MM.
  • [MeSH-major] Cervical Vertebrae / surgery. Neurosurgical Procedures / methods. Plasmacytoma / radiotherapy. Plasmacytoma / surgery. Spinal Neoplasms / radiotherapy. Spinal Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Bone Transplantation / methods. Combined Modality Therapy / methods. Combined Modality Therapy / statistics & numerical data. Female. Humans. Internal Fixators. Male. Middle Aged. Postoperative Complications / epidemiology. Prosthesis Implantation / methods. Radiotherapy / methods. Radiotherapy / statistics & numerical data. Reconstructive Surgical Procedures. Retrospective Studies. Survival Rate. Treatment Outcome

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  • (PMID = 20228695.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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44. Yumori JW, Ilsen P, Bright DC: Conjunctival plasmacytoma. Optometry; 2010 May;81(5):234-9
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  • [Title] Conjunctival plasmacytoma.
  • BACKGROUND: Plasmacytomas are plasma cell tumors that may be a primary or secondary tumor focus, the latter of which are associated with multiple myeloma.
  • We present a rare case of a solitary extramedullary plasmacytoma involving the conjunctiva.
  • The patient underwent excisional biopsy, which found a conjunctival plasmacytoma.
  • CONCLUSION: Although plasmacytomas of the eye and orbit are rare, it is important to be familiar with these tumors that may be associated with multiple myeloma.
  • Definitive diagnosis is made by biopsy and histopathologic examination of the tissue.
  • Plasmacytomas may be treated with external beam radiation, local excision, or radiotherapy after surgical excision.
  • Long-term follow-up, including periodic systemic evaluation, is required to establish that orbital involvement is not an early manifestation of multiple myeloma.
  • [MeSH-major] Conjunctival Neoplasms / diagnosis. Plasmacytoma / diagnosis

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  • [Copyright] Copyright 2010 American Optometric Association. All rights reserved.
  • (PMID = 20435269.001).
  • [ISSN] 1558-1527
  • [Journal-full-title] Optometry (St. Louis, Mo.)
  • [ISO-abbreviation] Optometry
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Dumesnil C, Schneider P, Dolgopolov I, Radi S, Leluyer B, Vannier JP: Solitary bone plasmocytoma of the spine in an adolescent. Pediatr Blood Cancer; 2006 Sep;47(3):335-8
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  • [Title] Solitary bone plasmocytoma of the spine in an adolescent.
  • Solitary plasmocytoma (SP) represent only about 5% of plasma cell neoplasia.
  • Most patients have generalized disease, that is, multiple myeloma (MM).
  • Solitary bone plasmocytoma (SBP) is a localized plasma cell tumor and is a very rare disease in young patients.
  • We reported here, a case of SPB in a 14-year-old girl with a 10-year disease-free survival after an aggressive treatment.
  • Recommendations on the diagnosis and management of SBP in adults, based on a literature search and consensus of expert opinion, were recently published on behalf of the Guidelines Working Group of the United Kingdom Myeloma Forum 1.
  • MRI of the spine is necessary to assess local disease.
  • Chemotherapy remains controversial in contrast to MM, in which intensive chemotherapy with autologous bone marrow transplantation (ABMT) is widely accepted.
  • At the present time, considering the good prognosis of patients with a normal MRI at diagnosis and a complete disappearance of the M protein after radiotherapy, we believe that ABMT should be reserved for relapse or primary therapeutic failure.
  • [MeSH-major] Bone Neoplasms / pathology. Plasmacytoma / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adolescent. Disease-Free Survival. Female. Humans. Magnetic Resonance Imaging. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / therapy. Prognosis. Sensitivity and Specificity. Treatment Outcome

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  • (PMID = 16086417.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. Dizdarević K, Masić T, Omerhodzić I, Babić M: [Craniofacial surgical treatment of the gigantic plasmacytoma of the skull base: case report]. Med Arh; 2006;60(3):195-7
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  • [Title] [Craniofacial surgical treatment of the gigantic plasmacytoma of the skull base: case report].
  • The complex craniofacial surgery of solitary bone plasmacytoma (SBP) of the skull base with excellent postoperative outcome was presented.
  • [MeSH-major] Plasmacytoma / surgery. Skull Base Neoplasms / surgery

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  • (PMID = 16719237.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] bos
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Bosnia and Herzegovina
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47. Yang F, Liu WP, Jiang LL, Li FY, Liao DY, Li GD: [Solitary plasmacytoma: a clinicopathologic and immunophenotypic analysis of 43 cases]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2006 Jan;37(1):93-6, 144
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  • [Title] [Solitary plasmacytoma: a clinicopathologic and immunophenotypic analysis of 43 cases].
  • OBJECTIVE: To investigate the clinicopathologic and immunophenotypic features of solitary plasmacytoma and discuss the diagnosis and differential diagnosis of the tumor.
  • METHODS: Clinicopathological study and follow up study were made on 43 cases of solitary plasmacytoma, including 24 cases of extramedullary plasmacytoma (EMP) and 19 cases of solitary plasmacytoma of bone (SPB).
  • Clinically, the neoplasms of 22 cases were located in nasal cavity or nasosinus, 2 cases were located in lung and tonsil respectively.
  • Clinically, the neoplasms of 8 cases were located in vertebrae, 3 cases in pelvis, 6 cases in clavicle, rib and femur respectively, 2 case in radius and tibia respectively.
  • Histopathological examination revealed tumor cells diffuse infiltration with necrosis and ulceration; the well-differentiated tumor cells were similar to the normal plasmacyte in shape; the poorly-differentiated tumor resembled centroblasts; there were a few interstitial tissues with plenty of vessels or formation of blood lakes; and there was deposition of amyloid materials.
  • Immunophenotypic analysis showed that all tumor cells were positive for CD79a and negative for CD20; that plasma cell marker (VS38C) was expressed in 41 cases; that light chain restriction was detected in all 43 cases( 31 for lamda and 12 for kappa), and that heavy chain expression was detected in 39 for IgG, 1 for IgA, 2 for both IgG and IgM, and 1 for IgA/IgG.
  • CONCLUSION: The special histopathology in this group of solitary plasmacytomas is presented.
  • The well-differentiated tumors should be distinguished from reactive plasmacytosis and MALT.
  • And, when poorly-differentiated solitary plasmacytomas were tentatively diagnosed, large cell lymphoma, melanoma and poorly differentiated carcinoma should be considered in differential diagnosis.
  • [MeSH-major] Antigens, CD20 / analysis. Antigens, CD79 / analysis. Immunoglobulins / analysis. Plasmacytoma / pathology
  • [MeSH-minor] Adolescent. Adult. Aged. Bone Neoplasms / metabolism. Bone Neoplasms / pathology. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Immunophenotyping. Male. Middle Aged

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  • (PMID = 16468652.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD20; 0 / Antigens, CD79; 0 / Immunoglobulins
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48. Marotta S, Di Micco P: Solitary plasmacytoma of the jaw. J Blood Med; 2010;1:33-6
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  • [Title] Solitary plasmacytoma of the jaw.
  • Solitary plasmacytoma may be considered as a rare neoplasm of head and neck and is a different disease compared to multiple myeloma.
  • The main difference is related to the better clinical prognosis of solitary plasmacytoma, which may be clinically silent for several years but several local recurrences may be possible once diagnosed and treated.
  • Clinical signs and symptoms of solitary plasmacytoma are related to bone pain and possible bone fractures.
  • Partial local impairment of local bone function may be present.
  • Bone swelling and local involvement of mucosa and local soft tissue may be revealed.
  • Other systemic dysfunctions as systemic bone marrow involvement with related anemia and absent thrombocytopenia.
  • However, although very rare, solitary plasmacytoma of the jaw may have several clinical presentations and here we review clinical differences reported in the literature.

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  • (PMID = 22282681.001).
  • [ISSN] 1179-2736
  • [Journal-full-title] Journal of blood medicine
  • [ISO-abbreviation] J Blood Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] New Zealand
  • [Other-IDs] NLM/ PMC3262320
  • [Keywords] NOTNLM ; bone function / fracture / monoclonal / multiple myeloma / solitary plasmacytoma
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49. Knobel D, Zouhair A, Tsang RW, Poortmans P, Belkacémi Y, Bolla M, Oner FD, Landmann C, Castelain B, Ozsahin M, Rare Cancer Network: Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study. BMC Cancer; 2006;6:118
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  • [Title] Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study.
  • BACKGROUND: Solitary plasmacytoma (SP) of the bone is a rare plasma-cell neoplasm.
  • METHODS: Data from 206 patients with bone SP without evidence of multiple myeloma (MM) were collected.
  • Histopathological diagnosis was obtained for all patients.
  • RESULTS: Five-year overall survival, disease-free survival (DFS), and local control was 70%, 46%, and 88%; respectively.
  • In multivariate analyses, favorable factors were younger age and tumor size < 5 cm for survival; younger age for DFS; anatomic localization (vertebra vs. other) for local control.
  • There was no dose-response relationship for doses 30 Gy or higher, even for larger tumors.
  • [MeSH-major] Bone Neoplasms / mortality. Plasmacytoma / mortality
  • [MeSH-minor] Actuarial Analysis. Adult. Age Factors. Aged. Aged, 80 and over. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Chemotherapy, Adjuvant. Cohort Studies. Combined Modality Therapy. Dexamethasone / administration & dosage. Disease Progression. Disease-Free Survival. Dose-Response Relationship, Radiation. Doxorubicin / administration & dosage. Europe / epidemiology. Female. Follow-Up Studies. Humans. Male. Melphalan / administration & dosage. Middle Aged. Multiple Myeloma / epidemiology. North America / epidemiology. Prednisone / administration & dosage. Prognosis. Proportional Hazards Models. Radiotherapy Dosage. Retrospective Studies. Spinal Neoplasms / drug therapy. Spinal Neoplasms / mortality. Spinal Neoplasms / pathology. Spinal Neoplasms / radiotherapy. Spinal Neoplasms / surgery. Treatment Outcome. Vincristine / administration & dosage

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  • (PMID = 16677383.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] England
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; Q41OR9510P / Melphalan; VB0R961HZT / Prednisone; VAD I protocol
  • [Other-IDs] NLM/ PMC1479355
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50. McNeil N, Kim JS, Ried T, Janz S: Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation. Genes Chromosomes Cancer; 2005 Jun;43(2):137-46
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  • [Title] Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation.
  • The cellular oncogene MYC and plasma cell growth, differentiation, and survival factor IL-6 play critical roles in the natural history of human plasma cell neoplasms such as multiple myeloma (MM).
  • Myc and IL-6 also are at the center of neoplastic plasma cell transformation in BALB/c mice that carry a human IL-6 transgene and, therefore, predictably develop plasmacytomas (PCTs).
  • We showed previously that, much like advanced MM or human myeloma cell lines (HMCLs), in which MYC is frequently deregulated in cis because of complex cytogenetic aberrations juxtaposing MYC to immunoglobulin enhancers, IL-6 transgenic PCTs commonly deregulate Myc in cis by chromosomal translocation, predominantly T(12;15)(Igh-Myc).
  • [MeSH-major] Genes, myc. Interleukin-6 / physiology. Plasmacytoma / genetics. Translocation, Genetic

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15751044.001).
  • [ISSN] 1045-2257
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Interleukin-6
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51. Kouno T, Watanabe T, Umeda T, Beppu Y, Kojima R, Sungwon K, Kobayashi Y, Tobinai K, Hasegawa T, Matsuno Y: CD56-positive small round cell tumor: osseous plasmacytoma manifested in osteolytic tumors of the iliac bone and femora. Jpn J Clin Oncol; 2005 Feb;35(2):90-3
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  • [Title] CD56-positive small round cell tumor: osseous plasmacytoma manifested in osteolytic tumors of the iliac bone and femora.
  • Monoclonal gammopathy of undetermined significance does not overexpress cluster of differentiation (CD) 56, but plasma cell myeloma frequently overexpressed it.
  • However, plasma cell leukemia and extramedullary plasmacytoma usually down-regulate CD56 expression.
  • Plasmacytoma, especially 'solitary plasmacytoma of bone', is difficult to diagnose as plasma cell neoplasm, because it occasionally appears similar to other bone tumors, both clinically and pathologically, and is rarely accompanied by monoclonal protein in the serum or urine.
  • The present case was a patient with an osteolytic 'small round cell tumor' of the iliac bone, which also invaded the femora.
  • An immunohistopathological finding of CD56 expression played a key role in making a diagnosis.
  • The definitive diagnosis of plasmacytoma was made based on the electron microscopic findings.
  • The plasma cells which infiltrated her sternum showed the same restriction to kappa light chain expression in their cytoplasms as that of the iliac bone tumor cells, but did not express CD56.
  • Locally infiltrating osteolytic bone tumors should be examined for surface immunoglobulin light chains as well as CD56 expression when plasmacytoma is suspected.
  • [MeSH-major] Antigens, CD56 / biosynthesis. Bone Neoplasms / diagnosis. Plasmacytoma / diagnosis

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  • (PMID = 15709094.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, CD56
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52. Moshref M, Mashhadi-Abbass F, Sargolzaei S, Nafarzadeh S: Extramedullary plasmacytoma of the gingiva. Arch Iran Med; 2007 Jan;10(1):91-3
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  • [Title] Extramedullary plasmacytoma of the gingiva.
  • Extramedullary plasmacytoma is defined as neoplastic proliferation of plasma cells in soft tissue.
  • It accounts for up to 3% of all plasma cell tumors.
  • Approximately, 90% of extramedullary plasmacytomas are found in the head and neck region commonly affecting the nasal cavity, paranasal sinuses, tonsillar fossa, and oral cavity.
  • We report a case of extramedullary plasmacytoma of the gingiva.
  • [MeSH-major] Gingival Neoplasms / pathology. Plasma Cells / pathology. Plasmacytoma / pathology
  • [MeSH-minor] Biopsy. Bone Marrow Cells / pathology. Diagnosis, Differential. Follow-Up Studies. Humans. Male. Middle Aged

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  • (PMID = 17198461.001).
  • [ISSN] 1029-2977
  • [Journal-full-title] Archives of Iranian medicine
  • [ISO-abbreviation] Arch Iran Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Iran
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53. Kashyap R, Kumar R, Kumar S: Cranial nerve palsy in multiple myeloma and solitary plasmacytoma. Asia Pac J Clin Oncol; 2010 Dec;6(4):251-5
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  • [Title] Cranial nerve palsy in multiple myeloma and solitary plasmacytoma.
  • Cranial nerve involvement in multiple myeloma and solitary plasmacytoma is rare.
  • We report on two patients who developed cranial nerve palsy due to skull base plasmacytoma.
  • Patient 1, a 55-year old man with multiple myeloma, developed right sixth cranial nerve palsy during a phase of chemotherapy.
  • He had an intracranial plasmacytoma in the clival region and was treated with 30 Gy whole brain radiotherapy.
  • Patient 2, a 40-year old man, presented with right third cranial nerve palsy and was detected to have a solitary skull base plasmacytoma.
  • [MeSH-major] Abducens Nerve Diseases / etiology. Multiple Myeloma / complications. Oculomotor Nerve Diseases / etiology. Plasmacytoma / complications. Skull Base Neoplasms / complications

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  • [Copyright] © 2010 Blackwell Publishing Asia Pty Ltd.
  • (PMID = 21114773.001).
  • [ISSN] 1743-7563
  • [Journal-full-title] Asia-Pacific journal of clinical oncology
  • [ISO-abbreviation] Asia Pac J Clin Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 4Z8R6ORS6L / Thalidomide; 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin; VAD protocol
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54. Rutsch S, Neppalli VT, Shin DM, DuBois W, Morse HC 3rd, Goldschmidt H, Janz S: IL-6 and MYC collaborate in plasma cell tumor formation in mice. Blood; 2010 Mar 4;115(9):1746-54
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  • [Title] IL-6 and MYC collaborate in plasma cell tumor formation in mice.
  • Interleukin-6 (IL-6) plays a critical role in the natural history of human plasma cell neoplasms (PCNs), such as plasma cell myeloma and plasmacytoma (PCT).
  • IL-6 is also at the center of neoplastic plasma cell transformation in BALB/c (C) mice carrying a transgene, H2-L(d)-IL6, that encodes human IL-6 under control of the major histocompatibility complex H2-L(d) promoter: strain C.H2-L(d)-IL6.
  • These mice are prone to PCT, but tumor development is incomplete with long latencies ( approximately 40% PCT at 12 months of age).
  • We found that double-transgenic C.H2-L(d)-IL6/iMyc(Emu) and C.H2-L(d)-IL6/iMyc(Calpha) mice develop PCT with full penetrance (100% tumor incidence) and short latencies (3-6 months).
  • The mouse tumors mimic molecular hallmarks of their human tumor counterparts, including elevated IL-6/Stat3/Bcl-X(L) signaling.

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  • (PMID = 20018915.001).
  • [ISSN] 1528-0020
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA097274; United States / NCI NIH HHS / CA / P50CA097274; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / IL6 protein, human; 0 / Interleukin-6
  • [Other-IDs] NLM/ PMC2832814
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55. Rivera J, Alves S, Bianchi CC, Al-Mutawa N, Guiot MC, Zeitouni A: An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. Pituitary; 2010 Jun;13(2):189-93
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  • [Title] An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region.
  • Urine protein electrophoresis revealed large free monoclonal kappa peaks while extensive plasmocytosis was evident in bone marrow aspirates.
  • On bone scan numerous lytic lesions were present.
  • A transsphenoidal excisional biopsy was performed which demonstrated two distinct populations of cells, corresponding to a plasma cell tumor and a lactotroph adenoma.
  • Treatment for multiple myeloma was initiated along with radiotherapy for the sellar tumor.
  • Only a few cases of solitary plasmocytomas of the pituitary region have been reported.
  • Few cases of prolactinomas coexisting with other sellar tumors has been described.
  • We discuss in this report possible pathogenic and functional connections between these two tumors.
  • We suggest that in the presence of extensive cranial nerve involvement, atypical imaging findings for a pituitary adenoma and severe hyperprolactinemia, the possibility of a collision tumor should lead the physician to consider excisional tumor biopsy or surgery in addition to dopamine agonist therapy.
  • [MeSH-major] Neoplasms, Multiple Primary / diagnosis. Pituitary Neoplasms / diagnosis. Plasmacytoma / diagnosis. Prolactinoma / diagnosis. Sella Turcica / pathology

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  • (PMID = 18846427.001).
  • [ISSN] 1573-7403
  • [Journal-full-title] Pituitary
  • [ISO-abbreviation] Pituitary
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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56. Janz S: Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice. J Natl Cancer Inst Monogr; 2008;(39):37-40
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  • [Title] Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice.
  • Peritoneal plasmacytomagenesis in inbred BALB/c mice affords an experimental model system for the study of the mechanism by which naturally occurring Myc (c-myc) translocations collaborate with host susceptibility factors and environmental influences in tumor development.
  • Mouse plasmacytoma is initiated in approximately 80% of cases by a balanced chromosomal T(12;15)(Igh-Myc) translocation that results in a mode of Myc deregulation that renders the survival and outgrowth of the translocation-bearing tumor precursor exquisitely dependent upon factors provided by sustained inflammation (IL-6) and gut flora microbes.
  • Tumor susceptibility genes of BALB/c, such as weak efficiency alleles of genes encoding p16(Ink4a) and Frap (mTOR), are also required for plasmacytoma, although the pathways linking these genes with deregulated Myc and the environment have not yet been elucidated.
  • The findings in mouse plasmacytoma may be relevant for hematopoietic neoplasms in human beings, in which leukemia- and lymphoma-associated chromosomal translocation (LLA-CT) is much more frequent than subsequent neoplasia.
  • Just like T(12;15)-carrying B-lymphocytes and plasma cells in mice, the malignant transformation of LLA-CT-bearing blood cells in humans may be a rare occurrence that requires several genetic and environmental cofactors to take place.
  • [MeSH-major] Environment. Genes, myc. Plasmacytoma / genetics. Translocation, Genetic

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  • (PMID = 18648000.001).
  • [ISSN] 1052-6773
  • [Journal-full-title] Journal of the National Cancer Institute. Monographs
  • [ISO-abbreviation] J. Natl. Cancer Inst. Monographs
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
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57. Handa U, Chhabra S, Mohan H: Plasma cell tumours: cytomorphological features in a series of 12 cases diagnosed on fine needle aspiration cytology. Cytopathology; 2010 Jun;21(3):186-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plasma cell tumours: cytomorphological features in a series of 12 cases diagnosed on fine needle aspiration cytology.
  • OBJECTIVE: Plasma cell tumours represent autonomous proliferation of plasma cells and can manifest as multiple myeloma, monoclonal gammopathy of undetermined significance, variants of plasma cell myeloma or plasmacytoma.
  • METHODS: We report 12 cases of plasma cell tumours, which were initially diagnosed as plasmacytoma on fine needle aspiration cytology (FNAC).
  • The patients were further subjected to bone marrow examination, serum electrophoresis, urine examination for Bence-Jones proteins, and x-ray examination of the skeleton.
  • RESULTS: The cytological smears from all cases were cellular and showed numerous plasma cells in varying degrees of maturity.
  • Subsequent to investigations, five cases were labelled as multiple myeloma with secondary extramedullary plasmacytoma, three as solitary bone plasmacytoma and two as primary extramedullary plasmacytoma.
  • In the remaining two cases, bone marrow and urine examination findings were not available, so a conclusive diagnosis of multiple myeloma or solitary plasmacytoma could not be made.
  • CONCLUSION: The study highlights the role of FNAC in the diagnosis of plasma cell tumours.
  • Subsequent work-up and follow-up of these patients is important to rule out the presence of multiple myeloma.
  • [MeSH-major] Plasma Cells / pathology. Plasmacytoma / diagnosis. Plasmacytoma / pathology

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  • (PMID = 19416310.001).
  • [ISSN] 1365-2303
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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58. Rutherford K, Parsons S, Cordes S: Extramedullary plasmacytoma of the larynx in an adolescent: a case report and review of the literature. Ear Nose Throat J; 2009 Feb;88(2):E1-7
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  • [Title] Extramedullary plasmacytoma of the larynx in an adolescent: a case report and review of the literature.
  • Extramedullary plasmacytoma is uncommon, accounting for only 3% of all plasma cell neoplasms.
  • Most cases of extramedullary plasmacytoma are seen in older men; presentation in an adolescent is rare.
  • We report the case of a 13-year-old girl who presented with a 2- to 3-month history of progressive dysphonia.
  • Biopsy indicated that the masses were extramedullary plasmacytomas with amyloid deposition.
  • The patient was treated with radiation therapy, and the tumors were eradicated.
  • We also review the literature with respect to the epidemiology and presentation of extramedullary plasmacytoma of the head and neck, specifically those that affect the larynx.
  • [MeSH-major] Laryngeal Neoplasms / diagnosis. Nasopharyngeal Neoplasms / diagnosis. Plasmacytoma / diagnosis

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  • (PMID = 19224468.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 69
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59. Rattican D, Kelly DL, Filler KA, Lyon DE: Back pain caused by a solitary plasmacytoma of bone. Clin J Oncol Nurs; 2010 Apr;14(2):149-52
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  • [Title] Back pain caused by a solitary plasmacytoma of bone.
  • This article presents initial diagnostic workup and criteria for diagnosing solitary plasmacytoma of bone (SPB) versus multiple myeloma.
  • The authors discuss the incorporation of current imaging technologies into the diagnosis and staging of SPB and multiple myeloma.

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  • (PMID = 20350888.001).
  • [ISSN] 1538-067X
  • [Journal-full-title] Clinical journal of oncology nursing
  • [ISO-abbreviation] Clin J Oncol Nurs
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA127446-04; United States / NCI NIH HHS / CA / R01 CA127446; United States / NCI NIH HHS / CA / R01 CA127446-04
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS282312; NLM/ PMC4881281
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60. Zazpe I, Caballero C, Cabada T, Guerrero D, Gallo-Ruiz A, Portillo E: Solitary thoracic intradural extramedullary plasmacytoma. Acta Neurochir (Wien); 2007;149(5):529-32; discussion 532
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  • [Title] Solitary thoracic intradural extramedullary plasmacytoma.
  • The bodies of the vertebrae are common locations for plasma cell diseases such as multiple myeloma and solitary plasmacytoma.
  • Spinal cord compression due to pure intradural plasma cell infiltration is very rare.
  • The authors report a 25-year-old woman who developed a progressive difficulty in walking due to a solitary spinal dural plasmacytoma.
  • This is the first reported example in the English language literature of a purely intradural spinal plasmacytoma in a patient without other myelomatous lesions.
  • An entirely intradural solitary plasmacytoma has a relatively better prognosis.
  • [MeSH-major] Plasmacytoma / pathology. Plasmacytoma / radiography. Spinal Cord Neoplasms / pathology. Spinal Cord Neoplasms / radiography

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  • (PMID = 17404683.001).
  • [ISSN] 0001-6268
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Austria
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61. Schor AP, Moraes MP, Bisson FW, Bisson MA, Luiz OM, Bacchi CE: Primary plasmacytoma of the cervix in a 21-year-old female patient. Int J Gynecol Pathol; 2010 May;29(3):290-3
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  • [Title] Primary plasmacytoma of the cervix in a 21-year-old female patient.
  • Extramedullary (extraosseous) plasmacytomas are localized, plasma cell neoplasms that arise in tissues other than bone and bone marrow, and constitute about 4% of all plasma cell neoplasms.
  • Extramedullary (extraosseous) plasmacytomas rarely affects the female lower genital tract; only 6 cases of primary cervix plasmacytomas have been reported to date.
  • This was confirmed by microscopic examination of a biopsy, which revealed a metaplastic process of the cervix with a massive infiltration of plasma cells with mild atypia.
  • The atypical plasma cells showed cytoplasmic lambda immunoglobulin light chain restriction with the absence of kappa light chains, indicative of monoclonality.
  • The patient was extensively screened for systemic disease, including bone marrow biopsy, but the disease was restricted to the cervix.
  • [MeSH-major] Plasmacytoma / pathology. Uterine Cervical Neoplasms / pathology

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  • (PMID = 20407332.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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62. Markou K, Karasmanis I, Goudakos JK, Papaioannou M, Psifidis A, Vital V: Extramedullary plasmacytoma of temporal bone: report of 2 cases and review of literature. Am J Otolaryngol; 2009 Sep-Oct;30(5):360-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extramedullary plasmacytoma of temporal bone: report of 2 cases and review of literature.
  • OBJECTIVE: The aim of the study was to report 2 cases of extramedullary plasmacytoma (EP) with localization to middle ear that were diagnosed and managed in our department.
  • Mild hearing loss and episodes of dizziness with sensation of falling for about 6 months were reported in the clinical history.
  • CONCLUSIONS: The prognosis of EP is considered favorable in regard to the solitary bone plasmacytoma and multiple myeloma (MM).
  • The differential diagnosis of EPs from other plasma cell dyscrasias and especially from MM is considered essential.
  • It is a radiosensitive tumor and, especially for EPs of temporal bone, the combined treatment of surgery resection and postoperative radiation seems to provide the best local control and the lower risk of occurrence.
  • [MeSH-major] Ear Neoplasms / pathology. Plasmacytoma / pathology. Temporal Bone / pathology
  • [MeSH-minor] Aged. Combined Modality Therapy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19720260.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 31
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63. Di Micco P, Di Micco B: Up-date on solitary plasmacytoma and its main differences with multiple myeloma. Exp Oncol; 2005 Mar;27(1):7-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Up-date on solitary plasmacytoma and its main differences with multiple myeloma.
  • Solitary plasmacytoma is plasma cell neoplasm.
  • It is a localized bone disease and for this reason it is different from multiple myeloma (systemic plasma cell neoplasm).
  • Sometimes, solitary plasmacytoma precedes a following multiple myeloma.
  • Clinical findings of solitary plasmacytoma are related to the univocal localization on damaged bone, while laboratory findings could be similar to multiple myeloma (i.e.
  • However, during a solitary plasmacytoma, laboratory findings could not be present contemporaneously such clinical complications (i.e. kidney failure, immunological disorders with a trend toward infectious disease and/or autoimmunity, neurological disorders, haematological disorders, amyloidosis, POEMS syndrome).
  • These raise the reason because solitary plasmacytoma has better prognosis compared to multiple myeloma.
  • [MeSH-major] Bone Neoplasms / physiopathology. Multiple Myeloma / physiopathology. Plasmacytoma / physiopathology

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  • (PMID = 15812350.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Review
  • [Publication-country] Ukraine
  • [Number-of-references] 55
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64. Ioannidis O, Kakoutis E, Varnalidis I, Tamouridis G, Chatzichristou A, Tzarou V, Makrantonakis N: Giant cutaneous plasmacytoma of the sacrococcygeal region. J Cutan Med Surg; 2010 Mar-Apr;14(2):90-4
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  • [Title] Giant cutaneous plasmacytoma of the sacrococcygeal region.
  • BACKGROUND: Cutaneous plasmacytoma is a very rare manifestation of extramedullary plasmacytoma, with only 32 cases having been reported so far in the last 60 years.
  • Extramedullary plasmacytoma is a plasma cell tumor that involves soft tissues, without any signs of systemic spread of multiple myeloma or bone marrow involvement.
  • OBJECTIVE AND CONCLUSION: We present a case of a giant cutaneous plasmacytoma of the sacrococcygeal region with a diameter of 12 cm that was treated with surgical excision.
  • [MeSH-major] Plasmacytoma / surgery. Skin Neoplasms / surgery
  • [MeSH-minor] Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male. Middle Aged. Plasma Cells / pathology. Sacrococcygeal Region

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  • (PMID = 20338125.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Mann G, Trebo MM, Minkov M, Simonitsch I, Chott A, Gadner H: Extramedullary plasmacytoma of the adenoids. Pediatr Blood Cancer; 2007 Mar;48(3):361-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extramedullary plasmacytoma of the adenoids.
  • Extramedullary plasmacytomas are extremely rarely diagnosed in children.
  • We report two cases of extramedullary plasmacytoma detected coincidentally in the adenoidectomy specimens of children younger than 4 years.
  • We show that these children are disease-free after local excision as the only treatment.
  • Surgical treatment without anti-neoplastic therapy in pediatric plasma cell dyscrasias of the pharyngeal lymphoid tissue may be a sufficient curative therapy.
  • [MeSH-major] Adenoids / pathology. Pharyngeal Neoplasms / pathology. Plasmacytoma / pathology

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16155934.001).
  • [ISSN] 1545-5009
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Immunoglobulin A; 0 / Immunoglobulin kappa-Chains; 0 / Neoplasm Proteins
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66. van Riet RP, Dreessen P: Solitary plasmocytoma of the distal humerus. J Hand Surg Am; 2006 Sep;31(7):1197-200
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary plasmocytoma of the distal humerus.
  • A patient presented with chronic shoulder pain from a rare plasmocytoma in the distal humerus that resolved following a pathologic fracture.
  • Staged reconstruction of the elbow after resection of the tumor in the distal humerus resulted in resolution of the patient's elbow and shoulder symptoms.
  • [MeSH-major] Bone Neoplasms / diagnosis. Humerus / pathology. Plasmacytoma / diagnosis
  • [MeSH-minor] Arthroplasty, Replacement. Elbow Joint / surgery. Humans. Humeral Fractures / diagnosis. Humeral Fractures / surgery. Male. Middle Aged. Pain / etiology

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  • (PMID = 16945727.001).
  • [ISSN] 0363-5023
  • [Journal-full-title] The Journal of hand surgery
  • [ISO-abbreviation] J Hand Surg Am
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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67. Kosaka N, Maeda M, Uematsu H, Matsumine A, Koshimoto Y, Itoh H: Solitary plasmacytoma of the sacrum. Radiologic findings of three cases. Clin Imaging; 2005 Nov-Dec;29(6):426-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary plasmacytoma of the sacrum. Radiologic findings of three cases.
  • We report the radiologic findings from three cases of solitary plasmacytoma (SP) of the sacrum.
  • These radiologic findings may be of utility when generating a differential diagnosis of a solitary sacral tumor.
  • [MeSH-major] Plasmacytoma / diagnosis. Sacrum. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Contrast Media. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 16274897.001).
  • [ISSN] 0899-7071
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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68. Ozdemir R, Kayiran O, Oruc M, Karaaslan O, Koçer U, Ogun D: Plasmacytoma of the hard palate. J Craniofac Surg; 2005 Jan;16(1):164-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Plasmacytoma of the hard palate.
  • Multiple myeloma is a systemic malignant disease and is associated with a poor prognosis.
  • It is characterized by neoplastic proliferation of plasma cells involved in the production and secretion of monoclonal immunoglobulins (M proteins).
  • It is generally a disseminated disease involving many bones.
  • Systemic symptoms include bone pain, pathologic fracture, renal failure, hypercalcemia, weight loss, anemia, thrombocytopenia, and neutropenia.
  • This condition may occur as a solitary lesion (solitary plasmacytoma), which in some patients eventually progresses to plasma cell myeloma.
  • Extramedullary plasmacytoma is defined as neoplastic proliferation of plasma cells in the soft tissue.
  • The authors present a rare plasmacytoma case with maxilla involvement.
  • [MeSH-major] Palatal Neoplasms / pathology. Palate, Hard / pathology. Plasmacytoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Multiple Myeloma / diagnosis

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  • (PMID = 15699668.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 59
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69. Chelly I, Mekni A, Bellil K, Belhadj Salah M, Bellil S, Haouet S, Kchir N, Horchani A, Zitouna M: [Testicular plasmocytoma: a case report]. Tunis Med; 2007 Aug;85(8):702-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Testicular plasmocytoma: a case report].
  • [Transliterated title] Le plasmocytome testiculaire: a propos d'un cas.
  • BACKGROUND: Extramedullary plasmocytoma is rare, with less than 50 reported cases and only 8 cases of primary testicular plasmocytoma.
  • AIM: Report of a new case CASE: This report concerns a 65-year-old patient presenting an enlargement of the testis.
  • The diagnosis of testicular plasmocytoma was made on histological examination.
  • There was no evidence of bone marrow involvement or systemic signs of myeloma.
  • [MeSH-major] Plasmacytoma / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18254296.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Tunisia
  • [Number-of-references] 10
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70. Iseri M, Ozturk M, Ulubil SA: Synchronous presentation of extramedullary plasmacytoma in the nasopharynx and the larynx. Ear Nose Throat J; 2009 Nov;88(11):E9-12
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Synchronous presentation of extramedullary plasmacytoma in the nasopharynx and the larynx.
  • Simultaneous extramedullary plasmacytoma of the nasopharynx and larynx is exceedingly rare; to the best of our knowledge, only 1 other case has been previously reported.
  • At 2 years of follow-up, no evidence of recurrence or progression to multiple myeloma was noted.
  • We discuss the clinical features and treatment of plasma cell neoplasms in general and their three variants in particular.
  • [MeSH-major] Laryngeal Neoplasms / diagnosis. Larynx / pathology. Nasopharyngeal Neoplasms / diagnosis. Nasopharynx / pathology. Plasmacytoma / diagnosis

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  • (PMID = 19924656.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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71. Kuo SF, Chang HY, Hsueh C, Lin JD: Extramedullary plasmacytoma of the thyroid. N Z Med J; 2006;119(1235):U2005
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extramedullary plasmacytoma of the thyroid.
  • Plasmacytomas of the thyroid are uncommon.
  • Final haematoxylin and eosin (HE) staining of the tumour confirmed a diagnosis of thyroid plasmacytoma.
  • Immunohistochemical staining showed that plasma cells were stained strongly with IgA antibody.
  • To date, this is the youngest patient with thyroid plasmacytoma in the literature.
  • Diagnosis of thyroid plasmacytoma by fine-needle aspiration cytology is typically difficult, as it was for this patient.
  • Currently, no treatment standard exists for thyroid plasmacytoma.
  • [MeSH-major] Plasmacytoma / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 16751828.001).
  • [ISSN] 1175-8716
  • [Journal-full-title] The New Zealand medical journal
  • [ISO-abbreviation] N. Z. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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72. Samprón N, Arrazola M, Urculo E: [Skull-base plasmacytoma with craniocervical instability]. Neurocirugia (Astur); 2009 Oct;20(5):478-83
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  • [Title] [Skull-base plasmacytoma with craniocervical instability].
  • [Transliterated title] Plasmocitoma de base craneal con inestabilidad cráneo-cervical.
  • INTRODUCTION: Cranio-cervical instability is, in some cases, the main surgical concern in posterior skull base tumors.
  • We report on a case in which a solitary plasmacytoma of the skull base presented with cranio-cervical instability.
  • CASE REPORT: A 66 year-old woman was diagnosed of a cranial base solitary plasmacytoma and treated with radio and chemotherapy with complete remission.
  • [MeSH-major] Atlanto-Occipital Joint / pathology. Joint Instability / etiology. Occipital Bone / pathology. Osteolysis / etiology. Plasmacytoma / complications. Quadriplegia / etiology. Skull Base Neoplasms / complications

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  • (PMID = 19830373.001).
  • [ISSN] 1130-1473
  • [Journal-full-title] Neurocirugía (Asturias, Spain)
  • [ISO-abbreviation] Neurocirugia (Astur)
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 7S5I7G3JQL / Dexamethasone; 80168379AG / Doxorubicin
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73. Coskun HS, Er O, Soyuer S, Altinbas M, Eser B, Karahacioglu E, Altuntas F: Solitary plasmacytoma: experiences from Central Anatolia. Ir J Med Sci; 2005 Jan-Mar;174(1):33-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary plasmacytoma: experiences from Central Anatolia.
  • BACKGROUND: Solitary plasmacytoma localised to bone or soft tissue without myeloma.
  • AIM: Clinical features and survival was analysed in patients from Central Anatolia.
  • METHODS: Twenty-three solitary plasmacytoma (18 male, 5 female) were evaluated retrospectively.
  • Multiple myeloma developed in eight patients (35%) and local relapse was detected in one patient.
  • Eight patients died, causes of death were multiple myeloma progression in six patients, local relapse of intracranial plasmacytoma in one patient and cranial trauma in one patient who was in complete remission.
  • CONCLUSION: Solitary plasmacytoma cases should be followed carefully regarding local relapse and progression to myeloma.
  • [MeSH-major] Bone Neoplasms / pathology. Multiple Myeloma / secondary. Plasmacytoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Disease Progression. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local. Retrospective Studies. Survival Analysis. Turkey

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  • (PMID = 15868887.001).
  • [ISSN] 0021-1265
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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74. Fernández López R, Borrego Dorado I, Paz Coll A, Vázquez Albertino R, Gómez Camarero P, Sanz Viedma S: [18F-FDG PET-CT in a case of solitary plasmacytoma of the soft palate]. Rev Esp Med Nucl; 2010 Sep-Oct;29(5):263-5
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  • [Title] [18F-FDG PET-CT in a case of solitary plasmacytoma of the soft palate].
  • [Transliterated title] Tomografía por emisión de positrones con ¹⁸F-fluorodeoxy-glucosa en un caso de plasmocitoma solitario de paladar blando.
  • Solitary plasmacytoma is an uncommon tumor of plasma cells that can appear in the head and neck.
  • It must be differentiated from multiple myeloma because of its initial presentation.
  • A case of solitary plasmacytoma on the palate is presented.
  • [MeSH-major] Fluorine Radioisotopes. Fluorodeoxyglucose F18. Palatal Neoplasms / radionuclide imaging. Palate, Soft / radionuclide imaging. Plasmacytoma / radionuclide imaging. Positron-Emission Tomography. Radiopharmaceuticals. Tomography, X-Ray Computed

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  • [Copyright] Copyright © 2010 Elsevier España, S.L. y SEMNIM. All rights reserved.
  • (PMID = 20663591.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Fluorine Radioisotopes; 0 / Immunoglobulin Light Chains; 0 / Paraproteins; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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75. Montero C, Souto A, Vidal I, Fernández Mdel M, Blanco M, Verea H: [Three cases of primary pulmonary plasmacytoma]. Arch Bronconeumol; 2009 Nov;45(11):564-6
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  • [Title] [Three cases of primary pulmonary plasmacytoma].
  • [Transliterated title] Plasmocitoma pulmonar primario: aportación de 3 casos.
  • Extramedullary plasmacytoma is a plasma cell malignancy that most commonly occurs in the upper respiratory tract.
  • Plasmocytoma located in the lung is an unusual finding, and in such cases the disease may be confined to the lung and regional lymph nodes or may be disseminated.
  • When only located in the lower respiratory tract (primary pulmonary plasmacytoma), diagnosis is difficult and is usually based on the excised tissue.
  • We present 3 cases, 2 of which were particularly unusual in that diagnosis was confirmed by bronchial biopsy.
  • Other important findings included the detection of paraprotein in the blood and urine of 2 of the patients, and follow-ups over 10 and 15 years without recurrence of the disease in 2 of the cases.
  • [MeSH-major] Lung Neoplasms / diagnosis. Plasmacytoma / diagnosis

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  • [CommentIn] Arch Bronconeumol. 2010 Aug;46(8):445-6 [20171774.001]
  • (PMID = 19523733.001).
  • [ISSN] 1579-2129
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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76. Monill J, Pernas J, Montserrat E, Pérez C, Clavero J, Martinez-Noguera A, Guerrero R, Torrubia S: CT features of abdominal plasma cell neoplasms. Eur Radiol; 2005 Aug;15(8):1705-12
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  • [Title] CT features of abdominal plasma cell neoplasms.
  • The aim of this study was to describe the CT features of abdominal plasma cell neoplasms.
  • We reviewed CT imaging findings in 11 patients (seven men, four women; mean age 62 years) with plasma cell neoplasms and abdominal involvement.
  • Diagnoses were made from biopsy, surgery and/or clinical follow-up findings.
  • Multiple myeloma was found in seven patients and extramedullary plasmacytoma in four patients.
  • All patients with multiple myeloma had multifocal disease with involvement of perirenal space (4/7), retroperitoneal and pelvic lymph nodes (3/7), peritoneum (3/7), liver (2/7), subcutaneous tissues (2/7) and kidney (1/7).
  • In three of the four patients with extramedullary plasmacytoma, a single site was involved, namely stomach, vagina and retroperitoneum.
  • Plasma cell neoplasm should be considered in the differential diagnosis of single or multiple enhancing masses in the abdomen or pelvis.
  • Abdominal plasma cell neoplasms were most frequently seen as well-defined enhancing masses (10/11).
  • [MeSH-major] Abdominal Neoplasms / radiography. Multiple Myeloma / radiography. Pelvic Neoplasms / radiography. Plasmacytoma / radiography. Tomography, Spiral Computed
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies

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  • (PMID = 16034641.001).
  • [ISSN] 0938-7994
  • [Journal-full-title] European radiology
  • [ISO-abbreviation] Eur Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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77. Araten DJ, Martinez-Climent JA, Perle MA, Holm E, Zamechek L, DiTata K, Sanders KJ: A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. Mutat Res; 2010 Apr 1;686(1-2):1-8
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  • [Title] A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene.
  • However, historically, the mutation rate (mu) has been difficult to measure directly, and increased cell turnover or selection could provide an alternative explanation.
  • We recently developed an assay for mu using PIG-A as a sentinel gene and estimated that its average value is 10.6 x 10(-7) mutations per cell division in B-lymphoblastoid cell lines (BLCLs) from normal donors.
  • Here we have measured mu in human malignancies and found that it was elevated in cell lines derived from T cell acute lymphoblastic leukemia, mantle cell lymphoma, follicular lymphoma in transformed phase, and 2 plasma cell neoplasms.
  • In contrast, mu was much lower in a marginal zone lymphoma cell line and 5 other plasma cell neoplasms.
  • The highest mu value that we measured, 3286 x 10(-7), is 2 orders of magnitude above the range we have observed in non-malignant human cells.

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  • [Copyright] Copyright 2010 Elsevier B.V. All rights reserved.
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  • (PMID = 20060400.001).
  • [ISSN] 0027-5107
  • [Journal-full-title] Mutation research
  • [ISO-abbreviation] Mutat. Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA109258-01; United States / NCI NIH HHS / CA / R01 CA109258; United States / NCI NIH HHS / CA / R01 CA109258-01; United States / NCI NIH HHS / CA / R01-CA109258
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Membrane Proteins; 0 / phosphatidylinositol glycan-class A protein
  • [Other-IDs] NLM/ NIHMS175233; NLM/ PMC2834866
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78. García Navalón C, Armengot Carceller M, Sabater Marco V, Reboll Ferrer RM, Frías Moya-Angeler S, Basterra Alegría J, Gutiérrez J: [Solitary extramedullary plasmocytoma of tubaric tonsil]. Acta Otorrinolaringol Esp; 2009 Jul-Aug;60(4):301-3
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  • [Title] [Solitary extramedullary plasmocytoma of tubaric tonsil].
  • [Transliterated title] Plasmocitoma solitario extramedular de amígdala tubárica.
  • Several histopathological modalities of tumours can grow in the rhinopharynx.
  • Solitary extramedullary plasmocytoma (SEP) is a low frequent variety of low-grade lymphoma.
  • They must be taken into account in the differential diagnosis of nasopharyngeal tumours.
  • [MeSH-major] Nasopharyngeal Neoplasms. Plasmacytoma

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  • (PMID = 19814980.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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79. Shahrizal TA, Prepageran N, Rahmat O, Mun KS, Looi LM: Isolated extramedullary plasmacytoma of the middle turbinate. Ear Nose Throat J; 2009 Feb;88(2):786-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Isolated extramedullary plasmacytoma of the middle turbinate.
  • Extramedullary plasmacytoma is a rare plasma cell proliferative disorder with a predilection for the head and neck region.
  • Occasionally, it presents as a solitary lesion in the nasal cavity.
  • We also review the pathology and management of plasmacytomas in general.
  • [MeSH-major] Nasal Cavity / pathology. Nose Neoplasms / diagnosis. Plasmacytoma / diagnosis. Turbinates / pathology

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  • (PMID = 19224479.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Nakanishi K, Kashiwagi N, Hamada K, Yagi T, Tomita Y: Solitary plasmacytoma of the sternum detected incidentally by MR imaging of the cervical spine. Magn Reson Med Sci; 2010;9(4):227-31
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  • [Title] Solitary plasmacytoma of the sternum detected incidentally by MR imaging of the cervical spine.
  • We incidentally detected a case of solitary plasmacytoma of the sternum by magnetic resonance (MR) imaging of the cervical spine.
  • At detection, the patient had no symptoms, the lesion was localized in the bone marrow of the sternum, and there were no findings of bone destruction.
  • The lesion showed high contrast on diffusion-weighted images, gradually enlarged over 3 years, and was confirmed as a solitary plasmacytoma at open biopsy 3 years after detection.
  • [MeSH-major] Cervical Vertebrae. Diffusion Magnetic Resonance Imaging / methods. Incidental Findings. Plasmacytoma / pathology. Sternum / pathology. Thoracic Neoplasms / pathology
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Middle Aged

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  • (PMID = 21187692.001).
  • [ISSN] 1880-2206
  • [Journal-full-title] Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
  • [ISO-abbreviation] Magn Reson Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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81. Mohammad Taheri Z, Mohammadi F, Karbasi M, Seyfollahi L, Kahkoei S, Ghadiany M, Fayazi N, Mansouri D: Primary pulmonary plasmacytoma with diffuse alveolar consolidation: a case report. Patholog Res Int; 2010;2010:463465
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  • [Title] Primary pulmonary plasmacytoma with diffuse alveolar consolidation: a case report.
  • Solitary extramedullary plasmacytomas are plasma cell tumors that tend to develop in mucosa-associated lymphoid tissues including the sinonasal or nasopharyngeal regions.
  • Primary plasmacytoma of the lung is exceedingly rare and often presents as a solitary mass or nodule in mid-lung or hilar areas and diagnosed after resection.
  • Herein, we report a case of primary pulmonary plasmacytoma that presented with diffuse alveolar consolidation and diagnosed by transbronchial lung biopsy.

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  • (PMID = 21151727.001).
  • [ISSN] 2042-003X
  • [Journal-full-title] Pathology research international
  • [ISO-abbreviation] Patholog Res Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2990464
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82. Schulze B, Kuchenbecker J, Fleige B, Krempien R, Ludwig WD, Schröter H: [Solitary extramedullary plasmocytoma of the conjunctiva]. Ophthalmologe; 2009 Feb;106(2):149-51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Solitary extramedullary plasmocytoma of the conjunctiva].
  • [Transliterated title] Isoliertes extraossäres Plasmozytom der Konjunktiva.
  • There is a wide variety of conjunctival tumors.
  • A good diagnosis can be reached by discussing the case history with the patient in conjunction with a slit-lamp examination.
  • Presented here is the case of a 39-year-old patient with a rapidly growing conjunctival tumor on his left eye.
  • After tumor resection and histological analysis, a plasmacytoma was found.
  • The completed hemato-oncological analysis gave no further suspicious pathological results, leading to the diagnosis of a solitary extramedullary plasmacytoma.
  • [MeSH-major] Conjunctiva / pathology. Conjunctival Neoplasms / diagnosis. Conjunctival Neoplasms / radiotherapy. Plasmacytoma / diagnosis. Plasmacytoma / radiotherapy

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  • (PMID = 18607603.001).
  • [ISSN] 1433-0423
  • [Journal-full-title] Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • [ISO-abbreviation] Ophthalmologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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83. Park BJ, Kalish RJ, Vercillo AP: Disseminated plasmacytoma of the thyroid. Ear Nose Throat J; 2010 Mar;89(3):137-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Disseminated plasmacytoma of the thyroid.
  • Extramedullary plasmacytomas most commonly occur in the nasal cavity, nasopharynx, paranasal sinuses, and larynx.
  • We report a new case of disseminated plasmacytoma of the thyroid, which occurred in a 68-year-old woman.
  • The diagnosis was made with an incisional biopsy.
  • We also briefly review the diagnostic and treatment options for patients with extramedullary plasmacytoma.
  • [MeSH-major] Plasmacytoma / pathology. Plasmacytoma / therapy. Thyroid Neoplasms / pathology. Thyroid Neoplasms / therapy

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  • (PMID = 20229481.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 7
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84. Huwer H, Jacobs G, Kalweit G, Püschel W: Solitary pulmonary plasmacytoma: report of two cases. Med Oncol; 2010 Mar;27(1):59-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary pulmonary plasmacytoma: report of two cases.
  • We report two cases of solitary plasmacytoma of the lung.
  • Computed tomographic scan disclosed in case A a solid tissue formation in a cystic pulmonary lesion and in case B a solitary nodule.
  • In both cases a diagnosis of plasmacytoma was made.
  • Postoperatively multiple myeloma was ruled out.
  • Solitary pulmonary plasmacytoma is a very rare condition and to the best of our knowledge plasmacytoma within a cystic lung lesion has not been described so far.
  • [MeSH-major] Lung Neoplasms / diagnosis. Plasmacytoma / diagnosis
  • [MeSH-minor] Aged. Aspergillus. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Mycetoma / diagnosis. Mycetoma / microbiology. Solitary Pulmonary Nodule / diagnosis. Thoracotomy. Young Adult

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  • (PMID = 19212709.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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85. Amo Trillo V, Vera García P, Pinto I, Olmedo Martín R, Romero Blasco B: [Extramedullary plasmacytoma of the colon]. Gastroenterol Hepatol; 2007 May;30(5):277-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extramedullary plasmacytoma of the colon].
  • [Transliterated title] Plasmocitoma extramedular de localización colónica.
  • We report the case of a 68 year-old man in whom a tumour of the colon was identified by colonoscopy, during diagnostic studies for lower gastrointestinal bleeding as an outpatient.
  • Histological examination showed clonal proliferation of plasma cells IgG-K.
  • No other location was affected (including bone marrow).
  • Diagnosis of plasmacytoma of the colon was made.
  • We have carried out a review of the literature in relation to this unusual disorder.
  • [MeSH-major] Plasmacytoma / diagnosis. Sigmoid Neoplasms / diagnosis

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  • (PMID = 17493438.001).
  • [ISSN] 0210-5705
  • [Journal-full-title] Gastroenterología y hepatología
  • [ISO-abbreviation] Gastroenterol Hepatol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; Q41OR9510P / Melphalan
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86. Megat Shiraz MA, Jong YH, Primuharsa Putra SH: Extramedullary plasmacytoma in the maxillary sinus. Singapore Med J; 2008 Nov;49(11):e310-1
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  • [Title] Extramedullary plasmacytoma in the maxillary sinus.
  • Extramedullary plasmacytoma is a rare malignant plasma cell tumour.
  • We report an extremely aggressive case of extramedullary plasmacytoma of the right maxillary sinus, which had metastasised to the brain and rib.
  • Magnetic resonance imaging revealed a right maxillary tumour with extension to the ipsilateral nasal cavity, nasopharynx, right sphenoid and ethmoidal sinuses.
  • Histopathology examination of the maxillary mass revealed abundant plasma cells with kappa-chain restriction.
  • Unfortunately, in view of the advanced stage of disease, he succumbed to his disease during the first cycle of chemotherapy.
  • [MeSH-major] Brain Neoplasms / diagnosis. Brain Neoplasms / pathology. Maxillary Sinus Neoplasms / diagnosis. Maxillary Sinus Neoplasms / radiography
  • [MeSH-minor] Anemia / complications. Antineoplastic Agents / therapeutic use. Fatal Outcome. Humans. Magnetic Resonance Imaging / methods. Male. Maxillary Sinus / pathology. Maxillary Sinus / radiography. Middle Aged. Nasopharynx / pathology. Neoplasm Metastasis. Plasmacytoma / diagnosis. Plasmacytoma / pathology. Plasmacytoma / radiography

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  • (PMID = 19037537.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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87. Gupta P, Rice GD, Abraham K, Ghole V, Ketkar M: Extramedullary plasmacytoma of the pancreas and jejunum. Clin Imaging; 2009 May-Jun;33(3):240-3
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  • [Title] Extramedullary plasmacytoma of the pancreas and jejunum.
  • Plasmacytomas occurring in the gastrointestinal tract are extremely rare.
  • We report one such case of pancreatic and jejunal plasmacytoma in a single patient with known multiple myeloma with emphasis on computed tomographic (CT) findings.
  • [MeSH-major] Jejunal Neoplasms / radiography. Neoplasms, Multiple Primary / radiography. Plasmacytoma / radiography. Tomography, X-Ray Computed
  • [MeSH-minor] Humans. Male. Middle Aged. Pancreatic Neoplasms

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  • (PMID = 19411034.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Marini A, Fenk R, Plettenberg H, Ruzicka T, Haas R, Hengge UR: [Rare types of vasculitis as markers of plasmocytoma]. Hautarzt; 2006 Feb;57(2):137-43
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  • [Title] [Rare types of vasculitis as markers of plasmocytoma].
  • [Transliterated title] Seltene Vaskulitiden als Hinweis auf Plasmozytom.
  • The results of all examinations and laboratory tests considered together suggested a diagnosis of necrotizing leukocytoclastic vasculitis.
  • Leukocytoclastic vasculitis is an inflammatory necrotizing condition of the superficial dermal vessels, presenting with variable clinical symptoms.
  • Common etiological factors include bacterial, viral or drug antigens, chronic infections (hepatitis B and C), non-Hodgkin lymphomas (monoclonal gammopathy, multiple myeloma), leukemia (hairy cell leukemia), and tumors (bronchial, breast, and gastric cancer) and also connective tissue disorders.
  • In the course of the work-up, a plasmocytoma was discovered as the cause of the leukocytoclastic vasculitis, presenting in a similar way to livedo reticularis in one case and to pyoderma gangraenosum in the other.
  • [MeSH-major] Plasmacytoma / complications. Plasmacytoma / diagnosis. Skin Neoplasms / complications. Skin Neoplasms / diagnosis. Vasculitis / diagnosis. Vasculitis / etiology
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Rare Diseases / diagnosis. Rare Diseases / etiology

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  • (PMID = 15657729.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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89. Cappuccio M, De Iure F, Gasbarrini A, Bandiera S, Boriani S: Solitary plasmacytoma of the spine: a 22 years follow-up case report. Eur Rev Med Pharmacol Sci; 2006 Sep-Oct;10(5):251-6
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  • [Title] Solitary plasmacytoma of the spine: a 22 years follow-up case report.
  • BACKGROUND AND OBJECTIVES: Plasmacytoma is a systemic malignancy and it is the most frequent primary tumor affecting the skeleton.
  • Progression from solitary plasmacytoma to systemic diffusion is reported to be 65-100% in 15 years.
  • A case report of a rare 22-year follow-up of a thoracic solitary plasmacytoma is here presented.
  • MATERIAL AND METHODS: Clinical case analysis, radiographs, magnetic resonance images and histological sections of the lesion are discussed.
  • Repeated surgical interventions were required due to progression and local recurrence of disease.
  • RESULTS: Although the inadequate surgical treatment, low response to chemotherapy and radiation therapy, and many local recurrences, no systemic diffusion of the disease was observed in 22 years.
  • [MeSH-major] Plasmacytoma / pathology. Spinal Neoplasms / pathology

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  • (PMID = 17121318.001).
  • [ISSN] 1128-3602
  • [Journal-full-title] European review for medical and pharmacological sciences
  • [ISO-abbreviation] Eur Rev Med Pharmacol Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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90. Gulías D, Fernández-Daponte C, Pombo J, Martínez-Sapiña MJ: [Primary bronchial plasmacytoma: computed tomography findings]. Radiologia; 2009 Sep-Oct;51(5):504-7
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  • [Title] [Primary bronchial plasmacytoma: computed tomography findings].
  • [Transliterated title] Plasmocitoma bronquial primario: hallazgos en tomografía computarizada.
  • Extramedullary plasmacytomas are malignant neoplasms of the plasmatic cells of the soft tissues.
  • Primary pulmonary plasmacytoma is the rarest type of extramedullary plasmacytoma.
  • The radiologic findings are unspecific and the diagnosis is histologic.
  • We present a case of primary endobronchial plasmacytoma in an adult diagnosed at histology.
  • [MeSH-major] Bronchial Neoplasms / radiography. Plasmacytoma / radiography. Tomography, X-Ray Computed

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  • (PMID = 19523660.001).
  • [ISSN] 0033-8338
  • [Journal-full-title] Radiología
  • [ISO-abbreviation] Radiologia
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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91. Jurisic V, Colovic N, Konjevic G, Minic I, Colovic M: An aggressive extramedullary cutaneous plasmacytoma associated with extreme alterations in the innate immune system. Onkologie; 2010;33(3):113-5
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  • [Title] An aggressive extramedullary cutaneous plasmacytoma associated with extreme alterations in the innate immune system.
  • BACKGROUND: The role of natural killer (NK) cells in plasma cell diseases has not yet been fully characterized.
  • CASE REPORT: We present the case of a 47-year-old man with an extremely aggressive extramedullary plasmacytoma of the lung with associated cutaneous lesions, whose disease was accompanied by a significantly decreased number of NK cells (CD56+, CD16+, CD3-) in the peripheral blood, very low NK cell activity levels, and a decreased interleukin-2 production from cultured cells in vitro.
  • Histology and immunohistochemistry of the lung and cutaneous lesions identified that the tumor was composed of clonal plasma cells which were CD38+++, CD138+++, lambda chain+, kappa chain-, and cytokeratin-.
  • Bone marrow histology and cytology were initially normal.
  • The disease progressed rapidly despite local radiotherapy and systemic chemotherapy, and the patient died shortly after diagnosis.
  • CONCLUSIONS: Cutaneous involvement in extramedullary plasmacytoma represents a clinically aggressive variant of plasma cell tumor, which runs a rapid course and has associated devastating effects on the patient's innate immune system.
  • [MeSH-major] Immune System Diseases / complications. Immune System Diseases / pathology. Killer Cells, Natural / pathology. Plasmacytoma / complications. Plasmacytoma / pathology. Skin Neoplasms / complications. Skin Neoplasms / pathology

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  • [Copyright] Copyright 2010 S. Karger AG, Basel.
  • (PMID = 20215803.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
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92. Huang WD, Feng DP, Xiao JR, Huang Q, Zheng W, Wu ZP, Zhou ZH, Yang XH, Xie N: [Surgical intervention and radiotherapy outcome of solitary plasmacytoma of cervical spine]. Zhonghua Wai Ke Za Zhi; 2010 May 1;48(9):697-701
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  • [Title] [Surgical intervention and radiotherapy outcome of solitary plasmacytoma of cervical spine].
  • OBJECTIVE: To study the clinical features, treatment methods and outcome of solitary plasmacytoma of cervical spine.
  • METHODS: From January 1995 to December 2007, the data of 23 cases with solitary plasmacytoma of cervical spine was analyzed.
  • The cervical spinal reconstruction was achieved through anterior cervical titanium plate and titanium mesh cage filled with auto iliac graft or bone cement, or anterior and posterior combined instrumented fusion.
  • The bone graft fusion rate was 100%.
  • During the follow-up period, 6 surgical cases had local recurrence and finally progressed to multiple myeloma (MM) and 3 died.
  • Two cases without surgical treatment progressed to MM in 1 year and 1.5 years after confirmed diagnosis.
  • The other 15 patients had disease-free survival and after surgery and adjunctive radiotherapy.
  • Obvious abnormity were not found in such examinations as M protein, bone marrow aspiration and emission computed tomography or PET-CT examinations.
  • CONCLUSIONS: Solitary plasmacytoma of cervical spine is rarely seen clinically.
  • Surgery is recommended as the primary management for patients with overt bone destruction and spinal instability or neurological dysfunction.
  • Tumor excision with adjunctive radiotherapy can obviously reduce local recurrences and lower the possibility of progression to MM.
  • [MeSH-major] Cervical Vertebrae. Plasmacytoma / surgery. Spinal Neoplasms / surgery

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  • (PMID = 20646555.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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93. Dores GM, Landgren O, McGlynn KA, Curtis RE, Linet MS, Devesa SS: Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. Br J Haematol; 2009 Jan;144(1):86-94
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  • [Title] Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004.
  • Population-based plasmacytoma incidence and survival data are sparse.
  • We analyzed incidence rates (IRs), IR ratios (IRRs), and 5-year relative survival for plasmacytoma overall and by site -- bone (P-bone) and extramedullary (P-extramedullary) -- in the Surveillance, Epidemiology and End Results (SEER) Program (1992-2004).
  • For comparison, we included cases of multiple myeloma (MM) diagnosed over the same time period in SEER.
  • Incidence of MM (n = 23,544; IR 5.35/100,000 person-years) was 16-times higher than plasmacytoma overall (n = 1543; IR = 0.34), and incidence of P-bone was 40% higher than P-extramedullary (P < 0.0001).
  • The male-to-female IRRs for P-bone, P-extramedullary, and MM were 2.0, 2.6, and 1.5, respectively.
  • For plasmacytoma and MM, IRs were highest in Blacks, intermediate in Whites, and lowest in Asian/Pacific Islanders.
  • Compared with Whites, the Black IR was approximately 30% higher for P-extramedullary and P-bone and 120% higher for MM.
  • IRs for all neoplasms increased exponentially with advancing age, less prominently at older ages for plasmacytoma than MM.
  • Distinct age, gender, and race incidence patterns of plasma cell disorders suggest underlying differences in clinical detection, susceptibility, disease biology and/or aetiological heterogeneity.
  • Five-year relative survival for P-bone, P-extramedullary, and MM varied significantly by age (<60/60+ years), supporting age-related differences in disease burden at presentation, disease biology, and/or treatment approaches.
  • [MeSH-major] Bone Neoplasms / epidemiology. Neoplasms, Plasma Cell / epidemiology
  • [MeSH-minor] Adult. Age Distribution. Aged. Aged, 80 and over. Confidence Intervals. Ethnic Groups. Female. Humans. Incidence. Male. Middle Aged. Mouth Neoplasms / epidemiology. Mouth Neoplasms / mortality. Multiple Myeloma / epidemiology. Multiple Myeloma / mortality. Pharyngeal Neoplasms / epidemiology. Pharyngeal Neoplasms / mortality. Plasmacytoma / epidemiology. Plasmacytoma / mortality. Respiratory Tract Neoplasms / epidemiology. Respiratory Tract Neoplasms / mortality. Sex Distribution. Survival Rate. United States / epidemiology

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  • (PMID = 19016727.001).
  • [ISSN] 1365-2141
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 CP010183-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS81923; NLM/ PMC2610331
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94. Nanni C, Rubello D, Zamagni E, Castellucci P, Ambrosini V, Montini G, Cavo M, Lodi F, Pettinato C, Grassetto G, Franchi R, Gross MD, Fanti S: 18F-FDG PET/CT in myeloma with presumed solitary plasmocytoma of bone. In Vivo; 2008 Jul-Aug;22(4):513-7
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  • [Title] 18F-FDG PET/CT in myeloma with presumed solitary plasmocytoma of bone.
  • AIM: To evaluate the value of 18F-fluorodeoxy-glucose (FDG) positron emission tomography with computed tomography (PET/CT) in myeloma in patients presenting with a solitary plasmacytoma of bone (SPB).
  • PATIENTS AND METHODS: Fourteen consecutive patients studied since 2006, all having a diagnosis of SPB before PET/CT imaging took part in this study.
  • In 6/8 patients, FDG uptake was considered pathologic, depicting myeloma involvement in bone, while in the remaining cases, findings were considered incidental and not related to myeloma.
  • PET findings attributed to myeloma were confirmed (i.e. true positives) in 6/6 cases (100%) and in all patients with findings reported as non-pathologic, myeloma was excluded (100% true negatives).
  • CONCLUSION: Our preliminary data in a small number of cases suggests that there are a group of patients with SPB (local disease) in whom FDG PET/CT may detect other unsuspected sites of bone involvement, upstaging the extent of the disease.
  • In these cases, SPB may be a local manifestation of multiple myeloma where other sites of involvement have eluded detection by other less sensitive imaging modalities (i.e. skeletal surveys) or anatomically restricted imaging (i.e., less than total body MR or CT).
  • Finding other sites of involvement have significant implications for appropriate treatment of myeloma.
  • [MeSH-major] Bone Neoplasms / complications. Bone Neoplasms / radionuclide imaging. Multiple Myeloma / complications. Multiple Myeloma / radionuclide imaging. Plasmacytoma / complications. Plasmacytoma / radionuclide imaging

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  • (PMID = 18712181.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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95. Yaman E, Benekli M, Coskun U, Sezer K, Ozturk B, Kaya AO, Yildiz R, Uluoglu O, Buyukberber S: Intrasellar plasmacytoma: an unusual presentation of multiple myeloma. Acta Neurochir (Wien); 2008 Sep;150(9):921-4; discussion 924
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  • [Title] Intrasellar plasmacytoma: an unusual presentation of multiple myeloma.
  • INTRODUCTION: Plasmacytomas are unusual causes of a sellar mass.
  • Occasionally, they can be misdiagnosed as a nonfunctioning adenoma because of radiological and clinical similarities.
  • Initial diagnosis of a nonfunctioning pituitary adenoma was later overruled by a repeat biopsy, which showed a plasmacytoma.
  • The tumor stained positively for CD138 and kappa light chain.
  • Further studies confirmed the diagnosis of multiple myeloma.
  • Because they have different therapeutic implications, extramedullary plasmacytomas involving pituitary gland should be considered in the differential diagnosis of a nonfunctioning pituitary mass.
  • [MeSH-major] Multiple Myeloma / complications. Multiple Myeloma / diagnosis. Pituitary Neoplasms / diagnosis. Pituitary Neoplasms / etiology. Plasmacytoma / diagnosis. Plasmacytoma / etiology
  • [MeSH-minor] Adenoma / diagnosis. Aged. Biopsy. Diagnosis, Differential. Female. Humans. Immunoglobulin kappa-Chains / metabolism. Magnetic Resonance Imaging. Sella Turcica. Syndecan-1 / metabolism

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  • (PMID = 18726062.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Chemical-registry-number] 0 / Immunoglobulin kappa-Chains; 0 / Syndecan-1
  • [Number-of-references] 24
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96. Fischer D, Bärmann M, Stasche N: [Extramedullary manifestation of plasmocytoma in ENT]. Laryngorhinootologie; 2007 Jan;86(1):48-50
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  • [Title] [Extramedullary manifestation of plasmocytoma in ENT].
  • Plasmocytomas are non-Hodgkin's tumors which occur with an incidence of 4/100,000.
  • Malignant plasma cells in bone marrow produce monoclonal antibodies which are typically found in urine and blood samples.
  • In rare instances plasmocytoma occur exclusively in extramedullary locations preferring head and neck region.
  • We report about two patients with extramedullary plasmocytoma, one of them with an extremely rare triple manifestation in the upper airway.
  • [MeSH-major] Arytenoid Cartilage. Glottis. Laryngeal Neoplasms / diagnosis. Multiple Myeloma / diagnosis. Pharyngeal Neoplasms / diagnosis. Tongue Neoplasms / diagnosis

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  • (PMID = 16586291.001).
  • [ISSN] 0935-8943
  • [Journal-full-title] Laryngo- rhino- otologie
  • [ISO-abbreviation] Laryngorhinootologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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97. de Jong D, Janz S: Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia. J Pathol; 2010 Jul;221(3):242-7
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  • [Title] Anaplastic plasmacytoma of mouse--establishing parallels between subtypes of mouse and human plasma cell neoplasia.
  • An ideal tumour model should replicate the phenotypic and molecular characteristics of human malignancy as well as the typical physiological effects and dissemination patterns.
  • The histopathological and molecular genetic characterization of anaplastic plasmacytoma (APCT) in strain NSF.V(+) mice provides an example to achieve this goal for a specific lymphoma subtype.
  • Firstly, it demonstrates that, like plasma-cell neoplasms in humans, those in mice occur as distinct subtypes.
  • Secondly, it shows that mouse APCT exhibits striking parallels to possible human tumour counterparts for which good mouse models of de novo tumour development are sorely needed: IgM(+) multiple myeloma and Waldenström's macroglobulinaemia.
  • Thirdly, it strongly suggests that insertional somatic mutagenesis, by either a murine leukaemia virus or an oncogenic transposon, would be an effective experimental approach to accelerating malignant transformation of mature B cells and plasma cells in mice and, thereby, tagging and uncovering cancer driver genes that may be of great relevance for the tumour initiation and progression in lymphoma.

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  • [Copyright] (c) 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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  • (PMID = 20527018.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA151354-01; United States / NCI NIH HHS / CA / R01 CA151354; United States / NCI NIH HHS / CA / R01 CA151354-01
  • [Publication-type] Comment; Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ NIHMS297320; NLM/ PMC3118561
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98. Park SH, Kim YZ, Lee EH, Kim KH: Endoscopic endonasal transsphenoidal resection of solitary extramedullary plasmacytoma in the sphenoid sinus with destruction of skull base. J Korean Neurosurg Soc; 2009 Aug;46(2):156-60
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Endoscopic endonasal transsphenoidal resection of solitary extramedullary plasmacytoma in the sphenoid sinus with destruction of skull base.
  • Solitary extramedullary plasmacytomas are isolated plasma cell tumors of soft tissue that typically do not metastasize.
  • They are rare and account for 4% of all plasma cell tumors.
  • To our knowledge, only 14 cases of solitary extramedullary plasmacytomas in the sphenoid sinus have been reported.
  • Histopathology was consistent with plasmacytoma.
  • Systemic work-up did not show any evidence of metastasis and the sphenoid sinus was the sole tumor site, and therefore the diagnosis of solitary extramedullary plasmacytoma was confirmed.
  • We report a rare case of solitary extramedullary plasmacytoma in the sphenoid sinus with successful treatment using the endoscopic endonasal transsphenoidal resection and adjuvant radiotherapy.

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  • (PMID = 19763219.001).
  • [ISSN] 2005-3711
  • [Journal-full-title] Journal of Korean Neurosurgical Society
  • [ISO-abbreviation] J Korean Neurosurg Soc
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2744026
  • [Keywords] NOTNLM ; Endoscopic surgical resection / Plasmacytoma / Sphenoid sinus
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99. Palomar Asenjo V, Borrás Perera M, Fortuny Llanses JC, Palomar García V: [Extramedullary plasmacytoma of the nasopharynx. Typical versus atypical presentation]. An Otorrinolaringol Ibero Am; 2006;33(2):159-67
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extramedullary plasmacytoma of the nasopharynx. Typical versus atypical presentation].
  • [Transliterated title] Plasmocitoma extramedular de nasofaringe. Presentación tipica versus presentación atípica.
  • Extramedullary plasmacytoma are rare plasma cell neoplasias.
  • Eighty percent of these tumours grow in the ENT region.
  • We report a typical case of a woman with a single tumour in the nasopharynx.
  • We also report an atypical case of a woman with a tumour in the nasopharynx associated with a cervical metastatic adenopathy and a plasmacytoma of bone.
  • The treatment of this widespread disease was systemic chemotherapy.
  • [MeSH-major] Nasopharyngeal Neoplasms / pathology. Plasmacytoma / secondary. Spinal Neoplasms / pathology

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  • (PMID = 16749724.001).
  • [ISSN] 0303-8874
  • [Journal-full-title] Anales otorrinolaringológicos ibero-americanos
  • [ISO-abbreviation] An Otorrinolaringol Ibero Am
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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100. Pantelidou D, Tsatalas C, Margaritis D, Karayiannakis AJ, Kaloutsi V, Spanoudakis E, Katsilieris I, Chatzipaschalis E, Sivridis E, Bourikas G: Extramedullary plasmacytoma: report of two cases with uncommon presentation. Ann Hematol; 2005 Mar;84(3):188-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extramedullary plasmacytoma: report of two cases with uncommon presentation.
  • Lymph node infiltration by monoclonal plasma cells can occur either in aggressive forms of myeloma or may represent regional extension of extramedullary plasmacytomas, whereas lymph node plasmacytoma presenting as a solitary extramedullary plasmacytoma is very unusual.
  • We report two cases of lymph node plasmacytomas without systemic disease diagnosed after surgical excision.
  • Clinical remission was achieved after local radiotherapy although one patient relapsed with multifocal extramedullary plasmacytomas 20 months after radiotherapy.
  • [MeSH-major] Plasmacytoma / pathology
  • [MeSH-minor] Abdominal Neoplasms / pathology. Aged. Humans. Male. Middle Aged. Neoplasm Invasiveness. Plasma Cells / pathology. Retroperitoneal Neoplasms / pathology. Tomography, X-Ray Computed

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  • (PMID = 15042315.001).
  • [ISSN] 0939-5555
  • [Journal-full-title] Annals of hematology
  • [ISO-abbreviation] Ann. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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