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56. de Bot ST, Dorresteijn LD, Haaxma CA, Kappelle AC, van de Warrenburg BP: [From psychiatric symptoms to paraneoplastic syndrome]. Tijdschr Psychiatr; 2008;50(9):603-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Transliterated title] Van psychiatrisch symptoom tot paraneoplastisch syndroom.
  • The first patient suffered from a mood disorder, personality changes and complained of several, hitherto unexplained physical symptoms.
  • Finally the patient was diagnosed with paraneoplastic cerebellar degeneration associated with Hodgkin's disease.
  • These cases illustrate that patients with paraneoplastic neurological syndromes may present with psychiatric symptoms which can hamper an early diagnosis.
  • [MeSH-major] Hodgkin Disease / psychology. Ovarian Neoplasms / psychology. Paraneoplastic Syndromes, Nervous System / psychology. Teratoma / psychology
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Tijdschr Psychiatr. 2008;50(11):755-6 [18991237.001]
  • (PMID = 18785107.001).
  • [ISSN] 0303-7339
  • [Journal-full-title] Tijdschrift voor psychiatrie
  • [ISO-abbreviation] Tijdschr Psychiatr
  • [Language] dut
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Netherlands
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57. Mohapatra PR, Bhuniya S, Garg S, Dimri K, Janmeja AK: Endobronchial non-Hodgkin's lymphoma presenting as mass lesion. Indian J Chest Dis Allied Sci; 2009 Apr-Jun;51(2):107-9
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  • [Title] Endobronchial non-Hodgkin's lymphoma presenting as mass lesion.
  • A 40-year-old male presented with clinical and radiological manifestations of right lung atelectasis and post-obstructive pneumonia.
  • Endobronchial biopsy from the mass lesion yielded low grade B-cell non-Hodgkin's lymphoma.
  • This is one of the rarest presentation of non-Hodgkin's lymphoma.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Lymphoma, Non-Hodgkin / diagnosis

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  • (PMID = 19445447.001).
  • [ISSN] 0377-9343
  • [Journal-full-title] The Indian journal of chest diseases & allied sciences
  • [ISO-abbreviation] Indian J Chest Dis Allied Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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58. Rudant J, Menegaux F, Leverger G, Baruchel A, Lambilliotte A, Bertrand Y, Patte C, Pacquement H, Vérité C, Robert A, Michel G, Margueritte G, Gandemer V, Hémon D, Clavel J: Childhood hematopoietic malignancies and parental use of tobacco and alcohol: the ESCALE study (SFCE). Cancer Causes Control; 2008 Dec;19(10):1277-90
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  • RESULTS: A total of 765 cases of acute leukemia (AL), 130 of Hodgkin's lymphoma (HL), 165 of non-Hodgkin's lymphoma (NHL) and 1681 controls were included.
  • For the four diseases, the ORs significantly increased with the number of cigarettes smoked.
  • No association with HL or with other types of NHL was observed.
  • [MeSH-major] Alcohol Drinking / adverse effects. Hematologic Neoplasms / classification. Hematologic Neoplasms / epidemiology. Prenatal Exposure Delayed Effects. Smoking / adverse effects
  • [MeSH-minor] Burkitt Lymphoma / epidemiology. Burkitt Lymphoma / pathology. Case-Control Studies. Child. Child, Preschool. Female. France / epidemiology. Hodgkin Disease / epidemiology. Hodgkin Disease / pathology. Humans. Incidence. Leukemia, Myeloid, Acute / epidemiology. Leukemia, Myeloid, Acute / pathology. Logistic Models. Lymphoma, Non-Hodgkin / epidemiology. Lymphoma, Non-Hodgkin / pathology. Male. Maternal Exposure / adverse effects. Odds Ratio. Paternal Exposure / adverse effects. Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology. Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology. Pregnancy. Registries / statistics & numerical data. Surveys and Questionnaires

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  • (PMID = 18618277.001).
  • [ISSN] 1573-7225
  • [Journal-full-title] Cancer causes & control : CCC
  • [ISO-abbreviation] Cancer Causes Control
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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59. Mondin V, Ferlito A, Devaney KO, Woolgar JA, Rinaldo A: A survey of metastatic central nervous system tumors to cervical lymph nodes. Eur Arch Otorhinolaryngol; 2010 Nov;267(11):1657-66
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  • In the realm of head and neck diseases, one particularly common clinical presentation is that of the patient with a cervical mass.
  • In children, neck masses often prove to be developmental cysts; in adults, the recent onset of a neck mass can signal a metastasis from a head and neck squamous carcinoma.
  • Less often, both adults and children may present with cervical masses caused by either non-Hodgkin's lymphoma or Hodgkin's disease.
  • Cervical node metastases may arise from glial tumors (including glioblastoma multiforme, in both adult and pediatric patients) and non-glial tumors (such as medulloblastoma in pediatric patients).
  • The history of a previous intracranial lesion is often the key to correct diagnosis, since, without prompting, neither the pathologist nor the radiologist is likely to think of a cervical node metastasis from a brain tumor when assessing a cervical mass of unknown etiology.

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  • (PMID = 20694730.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
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60. Vose JM, Link BK, Grossbard ML, Czuczman M, Grillo-Lopez A, Fisher RI: Long-term update of a phase II study of rituximab in combination with CHOP chemotherapy in patients with previously untreated, aggressive non-Hodgkin's lymphoma. Leuk Lymphoma; 2005 Nov;46(11):1569-73
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  • [Title] Long-term update of a phase II study of rituximab in combination with CHOP chemotherapy in patients with previously untreated, aggressive non-Hodgkin's lymphoma.
  • The present study aimed to determine the long-term safety and efficacy of chimeric anti-CD 20 antibody rituxan (rituximab, Biogen IDEC, San Diego, CA, USA; Genentech, South San Francisco, CA, USA) in combination with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy in previously untreated patients with aggressive non-Hodgkin's lymphoma (NHL).
  • Thirty-three patients with previously untreated aggressive B-cell NHL received six infusions of rituximab (375 mg/m(2) per dose) on day 1 of each cycle of CHOP chemotherapy, given on day 3 of each cycle of therapy.
  • Of the 33 patients, 2 patients experienced disease progression and subsequently died of their disease, 2 patients experienced disease progression but were alive at last follow-up following additional therapy, and 2 patients died without experiencing disease progression: one due to a cerebral vascular accident at 9 months after therapy and a second patient due to small cell lung carcinoma at 55 months.
  • [MeSH-major] Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Non-Hodgkin / drug therapy
  • [MeSH-minor] Adult. Aged. Antibodies, Monoclonal, Murine-Derived. Cause of Death. Cyclophosphamide / administration & dosage. Doxorubicin / administration & dosage. Female. Follow-Up Studies. Humans. Lymphoma, B-Cell / drug therapy. Lymphoma, B-Cell / mortality. Male. Middle Aged. Prednisone / administration & dosage. Remission Induction. Rituximab. Survival Analysis. Vincristine / administration & dosage

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  • (PMID = 16236611.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase II; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 4F4X42SYQ6 / Rituximab; 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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61. Dupuis J, Haioun C: [Non-Hodgkin lymphoma in the elderly]. Bull Cancer; 2008 May 28;95 FMC Onco:F79-83
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  • [Title] [Non-Hodgkin lymphoma in the elderly].
  • [Transliterated title] Lymphomes non hodgkiniens du sujet âgé: lymphome à grandes cellules B et lymphome folliculaire.
  • Non-Hodgkin's lymphomas form a heterogeneous group of tumors whose incidence is rising in elderly subjects.
  • Two approaches can thus be proposed: the first is to give the patient a conventional treatment with a higher risk of toxicity, the second one would be to propose a "lighter", dose-adapted treatment.
  • Two examples are examined more closely: diffuse large B-cell lymphomas and follicular lymphomas.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Non-Hodgkin / drug therapy
  • [MeSH-minor] Age Factors. Aged. Aged, 80 and over. Humans. Life Expectancy. Lymphoma, Follicular / drug therapy. Lymphoma, Large B-Cell, Diffuse / drug therapy. Prognosis

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  • (PMID = 18511372.001).
  • [ISSN] 1769-6917
  • [Journal-full-title] Bulletin du cancer
  • [ISO-abbreviation] Bull Cancer
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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62. Doorduijn J, Buijt I, Holt B, Steijaert M, Uyl-de Groot C, Sonneveld P: Self-reported quality of life in elderly patients with aggressive non-Hodgkin's lymphoma treated with CHOP chemotherapy. Eur J Haematol; 2005 Aug;75(2):116-23
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  • [Title] Self-reported quality of life in elderly patients with aggressive non-Hodgkin's lymphoma treated with CHOP chemotherapy.
  • We studied the impact of CHOP chemotherapy on the quality of life (QoL) of elderly patients with aggressive non-Hodgkin's lymphoma (NHL).
  • At baseline, QoL was significantly better on almost all dimensions in patients with a lower compared to patients with a higher age-adjusted International Prognostic Index (aaPI).
  • During follow-up, the QoL was significantly better for patients in complete response (CR) or partial remission (PR) than for patients with progression/relapse.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Lymphoma, Non-Hodgkin / drug therapy. Quality of Life

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  • [Copyright] Copyright Blackwell Munksgaard 2005.
  • (PMID = 16000127.001).
  • [ISSN] 0902-4441
  • [Journal-full-title] European journal of haematology
  • [ISO-abbreviation] Eur. J. Haematol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] Denmark
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol
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63. Latronico T, Liuzzi GM, Riccio P, Lichtner M, Mengoni F, D'Agostino C, Vullo V, Mastroianni CM: Antiretroviral therapy inhibits matrix metalloproteinase-9 from blood mononuclear cells of HIV-infected patients. AIDS; 2007 Mar 30;21(6):677-84
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  • DESIGN: Culture supernatants were collected from PBMC isolated from 46 HIV-infected subjects and 19 healthy donors (HD).
  • RESULTS: MMP-9 was significantly elevated in culture supernatants from PBMC of ART-naive subjects in comparison with HD.
  • Analysis by the reverse transcriptase polymerase chain reaction indicated that MMP-9 expression was increased in ART-naive subjects in comparison with HD but ART induced a decrease of MMP-9 expression to levels comparable with those of HD.
  • By contrast, in both HD and ART-treated subjects, there was no MMP-9 activity, indicating that MMP-9 was completely blocked by binding to its natural tissue inhibitor TIMP-1.

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  • (PMID = 17413688.001).
  • [ISSN] 0269-9370
  • [Journal-full-title] AIDS (London, England)
  • [ISO-abbreviation] AIDS
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Anti-Retroviral Agents; 0 / HIV Protease Inhibitors; 0 / Matrix Metalloproteinase Inhibitors; 0 / RNA, Messenger; 0 / RNA, Viral; 0 / Reverse Transcriptase Inhibitors; EC 3.4.24.35 / Matrix Metalloproteinase 9
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4. Büyükpamukçu M, Varan A, Akyüz C, Atahan L, Ozyar E, Kale G, Köksal Y, Kutluk T: The treatment of childhood Hodgkin lymphoma: improved survival in a developing country. Acta Oncol; 2009;48(1):44-51
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  • [Title] The treatment of childhood Hodgkin lymphoma: improved survival in a developing country.
  • BACKGROUND: To evaluate the clinical characteristics, treatment regimens, and outcome of children with Hodgkin lymphoma in a developing country over a period of 34 years.
  • METHODS: This paper retrospectively evaluates the treatment and prognosis of 614 children with Hodgkin lymphoma disease between 1971 and 2005.
  • Histopathologic subtypes were mixed cellularity (344 patients), nodular sclerosis (90), lymphocytic predominance (62), lymphocytic depletion (46), unclassified types (69), and nodular lymphocyte predominant Hodgkin lymphoma (3).
  • Overall (OS) and event-free survival (EFS) rates were 83 and 60%, though OS rates varied according to chemotherapy protocol; age; presence of B symptoms, leukocytosis, anemia, and extranodal involvement; and stage at diagnosis.
  • Over the years, the median age of patients increased, as did the frequency of the nodular sclerosing type of disease.
  • The increase in the median age and in the frequency of the nodular-sclerosing type are thought to be related to the development status of Turkey.
  • The ABVD protocol yielded the best survival rates and should be used for treatment of patients with Hodgkin lymphoma.
  • [MeSH-major] Hodgkin Disease / mortality. Hodgkin Disease / therapy


65. Aleman BM, Girinsky T, van der Maazen RW, Strijk S, Meijnders P, Bortolus R, Olofsen-van Acht MJ, Lybeert ML, Lievens Y, Eghbali H, Noordijk EM, Tomsic R, Meerwaldt JH, Poortmans PM, Smit WG, Pinna A, Henry-Amar M, Raemaekers JM, European Organization for Research, Treatment of Cancer (EORTC) Lymphoma Group: Quality control of involved-field radiotherapy in patients with advanced Hodgkin's lymphoma (EORTC 20884). Int J Radiat Oncol Biol Phys; 2005 Nov 15;63(4):1184-90
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  • [Title] Quality control of involved-field radiotherapy in patients with advanced Hodgkin's lymphoma (EORTC 20884).
  • PURPOSE: To evaluate the impact of the quality of involved-field radiotherapy (IFRT) on clinical outcome in patients with advanced Hodgkin's lymphoma (HL) in complete remission (CR) after six to eight cycles of mechlorethamine, vincristine, procarbazine, prednisone-doxorubicin, bleomycin, and vinblastine (MOPP-ABV) chemotherapy.
  • METHODS AND MATERIALS: A retrospective review of clinical and radiologic data, radiation charts, simulator films, and megavoltage (MV) photographs was performed.
  • Major violations were defined as no or only partial irradiation of an originally involved area, or a total dose <90% of the prescribed dose.
  • The total dose was correct in 81% of the patients.
  • There was no relationship between incidence or site of relapse and major protocol violations.
  • CONCLUSION: In advanced-stage HL patients in complete remission after six to eight cycles of MOPP-ABV, the outcome was not influenced by violation of the radiotherapy protocol.
  • [MeSH-major] Hodgkin Disease / radiotherapy. Quality Control

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  • (PMID = 15936157.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 35S93Y190K / Procarbazine; 50D9XSG0VR / Mechlorethamine; 5J49Q6B70F / Vincristine; 5V9KLZ54CY / Vinblastine; 80168379AG / Doxorubicin; VB0R961HZT / Prednisone; MOPP protocol; VBA protocol
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66. Macdonald DA, Ding K, Gospodarowicz MK, Wells WA, Pearcey RG, Connors JM, Winter JN, Horning SJ, Djurfeldt MS, Shepherd LE, Meyer RM: Patterns of disease progression and outcomes in a randomized trial testing ABVD alone for patients with limited-stage Hodgkin lymphoma. Ann Oncol; 2007 Oct;18(10):1680-4
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  • [Title] Patterns of disease progression and outcomes in a randomized trial testing ABVD alone for patients with limited-stage Hodgkin lymphoma.
  • BACKGROUND: In the National Cancer Institute of Canada Clinical Trials Group/Eastern Cooperative Oncology Group HD.6 trial, progression-free survival was better in patients randomized to therapy that included radiation, compared to doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine (ABVD) alone.
  • CONCLUSION: Treatment that includes radiation reduces the risk of progressive Hodgkin lymphoma in sites that receive this therapy, but we are unable to detect differences in FF2P or FF2P/D.

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  • (PMID = 17846017.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] England
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin
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67. Gao S, Han H, Feng HL, Zhao SJ, Meng QW: Overexpression and suppression of violaxanthin de-epoxidase affects the sensitivity of photosystem II photoinhibition to high light and chilling stress in transgenic tobacco. J Integr Plant Biol; 2010 Mar;52(3):332-9
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  • [Title] Overexpression and suppression of violaxanthin de-epoxidase affects the sensitivity of photosystem II photoinhibition to high light and chilling stress in transgenic tobacco.
  • Tobacco (Nicotiana tabacum) transformed with the sense and antisense constructs of tomato (Lycopersicon esculentum) violaxanthin de-epoxidase gene (LeVDE) was obtained under the control of the cauliflower mosaic virus 35S promoter (35S-CaMV).
  • Wild type (WT), the sense-transgenic line T(1)-24(+) and the antisense-transgenic line T(1)-17(-) were used for physiological measurement.
  • The ratio of (A+Z)/(V+A+Z) and non-photochemical quenching in WT were lower than that in sense plants and higher than that in antisense ones under high light and chilling stress with low irradiance.
  • The maximal photochemical efficiency of photosystem II (PSII) (Fv/Fm) and the net photosynthetic rate (Pn) in the sense line decreased less, while Fv/Fm and Pn in the antisense line decreased most obviously among all lines.
  • These results suggest that the expression of the violaxanthin de-epoxidase gene in transgenic plants affects the sensitivity of PSII photoinhibition to high light and chilling stress.

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  • (PMID = 20377694.001).
  • [ISSN] 1744-7909
  • [Journal-full-title] Journal of integrative plant biology
  • [ISO-abbreviation] J Integr Plant Biol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China (Republic : 1949- )
  • [Chemical-registry-number] 0 / Photosystem II Protein Complex; 0 / RNA, Antisense; 0 / Xanthophylls; EC 1.- / Oxidoreductases; EC 1.- / violaxanthin de-epoxidase
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68. van der Meer MA, Knierim JJ, Yoganarasimha D, Wood ER, van Rossum MC: Anticipation in the rodent head direction system can be explained by an interaction of head movements and vestibular firing properties. J Neurophysiol; 2007 Oct;98(4):1883-97
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  • The rodent head-direction (HD) system, which codes for the animal's head direction in the horizontal plane, is thought to be critically involved in spatial navigation.
  • Electrophysiological recording studies have shown that HD cells can anticipate the animal's HD by up to 75-80 ms.
  • In this modeling study, we provide a novel explanation for HD anticipation that relies on the firing properties of neurons afferent to the HD system.
  • In addition, HD anticipation varies between recording sessions of the same cell, between active and passive movement, and between different studies.
  • We conclude that HD afferent dynamics and the statistics of rat head movements are important in generating HD anticipation.
  • This result contributes to understanding the functional circuitry of the HD system and has methodological implications for studies of HD anticipation.

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  • (PMID = 17596421.001).
  • [ISSN] 0022-3077
  • [Journal-full-title] Journal of neurophysiology
  • [ISO-abbreviation] J. Neurophysiol.
  • [Language] eng
  • [Grant] United States / NINDS NIH HHS / NS / R01 NS39456
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. You Y, Xia LH, Zhang C, Liu F, Chen ZC, Zou P: [Clinical observation of selected CD34(+) cell autologous transplantation in non-Hodgin lymphoma: report of 5 cases]. Zhonghua Yi Xue Za Zhi; 2007 Nov 27;87(44):3127-9
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  • [Title] [Clinical observation of selected CD34(+) cell autologous transplantation in non-Hodgin lymphoma: report of 5 cases].
  • OBJECTIVE: To investigate the clinical effect of peripheral blood progenitor (PBPC) selected CD34(+) cell autologous transplantation in non-Hodgin lymphoma (NHL) patients.
  • METHODS: Peripheral blood was collected from 5 NHL patients, 3 males and 2 females, aged 29 (14 - 58), t3 with T cell NHL, 1 with diffused large B cell NHL and 1 with genuine histiocytic lymphoma, 2 at the IIA stage and 3 at the IVB stage, and 4 in their first complete remission (CR1) period, and 1 in partial remission (PR2).
  • RESULTS: Magnetic-activated cell sorting resulted in 3.3 log depletion of CD34(-) cells and a median yield of CD34(+) selected cells was reinfused with the dose of 2.0 x 10(6)/kg.
  • CONCLUSION: Brings prompt and stable engraftment, autologous selected PBPC CD34(+) cells transplantation may safely improve the clinical outcome of the patients with NHL.
  • [MeSH-major] Antigens, CD34 / blood. Lymphoma, Non-Hodgkin / surgery. Peripheral Blood Stem Cell Transplantation / methods

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  • (PMID = 18269872.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD34
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70. Hahn T, Benekli M, Wong C, Moysich KB, Hyland A, Michalek AM, Alam A, Baer MR, Bambach B, Czuczman MS, Wetzler M, Becker JL, McCarthy PL: A prognostic model for prolonged event-free survival after autologous or allogeneic blood or marrow transplantation for relapsed and refractory Hodgkin's disease. Bone Marrow Transplant; 2005 Mar;35(6):557-66
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  • [Title] A prognostic model for prolonged event-free survival after autologous or allogeneic blood or marrow transplantation for relapsed and refractory Hodgkin's disease.
  • There are several prognostic models for Hodgkin's disease (HD) patients, but none evaluating patient characteristics at time of blood and marrow transplantation (BMT).
  • We developed a prognostic model for event-free survival (EFS) post-BMT based on HD patient characteristics measured at the time of autologous (auto) or allogeneic (allo) BMT.
  • Between 1/1991 and 12/2001, 64 relapsed or refractory HD patients received an auto (n=46) or allo (n=18) BMT.
  • Significant multivariate predictors of shorter EFS were chemotherapy-resistant disease, KPS <90 and > or =3 chemotherapy regimens pre-BMT.
  • [MeSH-major] Bone Marrow Transplantation. Hodgkin Disease / diagnosis. Hodgkin Disease / therapy. Peripheral Blood Stem Cell Transplantation. Prognosis
  • [MeSH-minor] Adult. Cause of Death. Disease-Free Survival. Drug Resistance, Neoplasm. Female. Graft Survival. Humans. Male. Middle Aged. Models, Theoretical. Multivariate Analysis. Salvage Therapy. Survival Analysis. Time. Transplantation, Autologous. Transplantation, Homologous


71. Ryerson CJ, Churg A, Wilcox PG: A 48-year-old woman with remote hodgkin disease and bilateral pleural effusions. Chest; 2009 Sep;136(3):934-937
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  • [Title] A 48-year-old woman with remote hodgkin disease and bilateral pleural effusions.
  • [MeSH-major] Hodgkin Disease / complications. Mesothelioma / diagnostic imaging. Peritoneal Neoplasms / diagnostic imaging. Pleural Effusion, Malignant / diagnostic imaging. Pleural Effusion, Malignant / etiology. Pleural Neoplasms / diagnostic imaging
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Female. Humans. Laparoscopy. Middle Aged. Radiography, Thoracic. Tomography, X-Ray Computed

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  • (PMID = 19736198.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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72. Pan ZH, Huang HQ, Lin XB, Xia YF, Xia ZJ, Peng YL, Cai QQ, Lin TY, Jiang WQ, Guan ZZ: [Prognostic analysis of patients with nasal-type NK/T-cell non-Hodgkin's lymphoma--a report of 93 cases]. Ai Zheng; 2005 Dec;24(12):1493-7
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  • [Title] [Prognostic analysis of patients with nasal-type NK/T-cell non-Hodgkin's lymphoma--a report of 93 cases].
  • BACKGROUND & OBJECTIVE: Nasal-type NK/T-cell non-Hodgkin's lymphoma (NHL) is a unique subtype with the manifestation of local necrosis, infection and fever.
  • The efficacy of chemotherapy alone is unsatisfactory; while radiochemotherapy plays some roles in the management of NK/T-cell lymphoma (NK/TCL).
  • This study was to summarize the clinical characteristics, treatment outcome and prognosis of NK/TCL patients.
  • All the patients were classified according to WHO classification system.
  • The disease course was 1-24 months with a median of 6.5 months.
  • Of the 93 patients, 15 (16.1%) presented perforation of hard palate and/or nasal septum, 35 (37.6%) presented B symptoms; 35 (37.6%) were treated with chemotherapy alone, 2 (2.2%) were treated with radiotherapy alone, 54 (58.0%) were treated with radiochemotherapy, and 2 (2.2%) received no treatment.
  • The first-line chemotherapy regimens were mainly CHOP and EPOCH.
  • Multivariate analysis showed that perforation of hard palate and/or nasal septum, B symptoms and therapeutic modality were independent prognostic factors of NK/TCL (P=0.035, P<0.001, and P=0.004).
  • [MeSH-major] Killer Cells, Natural / pathology. Lymphoma, T-Cell. Nose Neoplasms

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  • (PMID = 16351799.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; VB0R961HZT / Prednisone; CHOP protocol; EPOCH protocol
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73. Lehmberg K, Steinhausen B, Janka G: From neonates to adolescents--the diagnostic significance of pitted erythrocytes in hyposplenic and asplenic children. Klin Padiatr; 2007 Nov-Dec;219(6):339-42
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  • BACKGROUND: Splenic function may be reduced or absent in a range of medical conditions in childhood, most prominently in homozygous sickle cell disease, celiac disease, or after total or partial splenectomy.
  • In neonates and patients with malignant disease, transient hyposplenia has been reported as well.
  • A simple method with reliable reference values is required to determine a patient's splenic function and thereby assess the risk of systemic infection.
  • This included splenectomized individuals, patients at risk for hyposplenia (homozygous sickle cell anemia (HbSS), leukemia, nephroblastoma and Hodgkin's disease after irradiation, patients after stem cell transplantation (SCT)), term and preterm neonates, and 90 controls (0-20 years of age, no neonates).
  • For clinical purposes, the degree of hyposplenia can be determined to give an estimation of the risk of severe infection, e.g. in patients with HbSS or after partial splenectomy.
  • [MeSH-major] Anemia, Sickle Cell / diagnosis. Erythrocytes, Abnormal. Spleen / physiology. Splenectomy

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  • (PMID = 18050044.001).
  • [ISSN] 0300-8630
  • [Journal-full-title] Klinische Pädiatrie
  • [ISO-abbreviation] Klin Padiatr
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Germany
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74. Pongpruttipan T, Sitthinamsuwan P, Rungkaew P, Ruangchira-urai R, Vongjirad A, Sukpanichnant S: Pitfalls in classifying lymphomas. J Med Assoc Thai; 2007 Jun;90(6):1129-36
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  • [Title] Pitfalls in classifying lymphomas.
  • BACKGROUND: Although the WHO classification (2001) requires a great deal of morphologic, immunophenotypic, genetic, and clinical features for classifying lymphomas, it is still feasible to misdiagnose under limited resources, especially a limited panel of antibodies used for immunophenotyping.
  • To identify pitfalls in classifying lymphomas among hematopathologist, general pathologists, and pathology residents under this situation.
  • MATERIAL AND METHOD: Newly diagnosed lymphoma cases from 1 July 2002 to 30 June 2003 at Siriraj Hospital were included for two rounds of individually blinded review by a hematopathologist, two general pathologists, and three pathology residents.
  • RESULTS: One hundred and four lymphoma cases included 61 diffuse large B-cell lymphoma (DLBCL, 58.6%), 12 MALT lymphoma (11.5%), eight follicular lymphoma (FL, 7.7%), seven classical Hodgkin lymphoma (HL, 6.7%), four unspecified peripheral T-cell lymphoma (PTCL, 3.8%), three Burkitt lymphoma (BL, 2.9%), two subcutaneous panniculitis-like T-cell lymphoma (SPTCL, 1.9%), and seven other uncommon types (1% each).
  • Pitfalls were low infrequency on diagnosis of DLBCL, nodular sclerosis HL, and SPTCL (8% each), but not different among the participants only in DLBCL.
  • Pitfalls in diagnosis of MALT lymphoma, mixed cellularity HL, BL, unspecified PTCL, and FL were 60%, 50%, 33%, 29%, and 24%, respectively.
  • However, considering hematopathologist and non-hematopathologist groups, pitfalls in the former were lower, especially in the uncommon types of lymphoma.
  • CONCLUSION: Pitfalls in classifying lymphomas are common.
  • Interest in hematopathology reduces misdiagnosis in lymphomas other than DLBCL.
  • [MeSH-major] Diagnostic Errors. Immunophenotyping / standards. Lymphoma / classification
  • [MeSH-minor] Humans. Pathology, Clinical / education. Pathology, Clinical / standards. Pilot Projects. Thailand. World Health Organization

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  • (PMID = 17624207.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Thailand
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75. McPhee E, Eskander JP, Eskander MS, Mahan ST, Mortimer E: Imaging in pelvic osteomyelitis: support for early magnetic resonance imaging. J Pediatr Orthop; 2007 Dec;27(8):903-9
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  • As a result, accurate diagnosis is often delayed, and children may undergo surgical diagnostic or therapeutic procedures that may be avoided.
  • We report the radiographic and magnetic resonance imaging (MRI) findings in 23 children admitted with a suspected diagnosis of pelvic osteomyelitis.
  • We are presenting imaging findings in children with suspected pelvic osteomyelitis with emphasis on MRI abnormalities and to propose an anatomical classification based on the patterns of pelvic involvement.
  • Criteria were defined for the diagnosis of pelvic osteomyelitis based on criteria used by Farley et al in 1985.
  • Specific attention was paid to the imaging strategies used and the influence of each radiographic method on the ultimate diagnosis.
  • One patient had a noninfectious cause of presentation with a deep vein thrombosis, whereas another was diagnosed with Hodgkin lymphoma in addition to osteomyelitis of the ischium.
  • In patients presenting with clinical findings and laboratory studies suggesting an infectious process, MRI with gadolinium enhancement should be performed as an early study.
  • [MeSH-minor] Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Image Processing, Computer-Assisted. Male

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  • (PMID = 18209613.001).
  • [ISSN] 0271-6798
  • [Journal-full-title] Journal of pediatric orthopedics
  • [ISO-abbreviation] J Pediatr Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Basecke J, Podleschny M, Becker A, Seiffert E, Schwiers I, Schwiers R, Haase D, Glass B, Schmitz N, Trumper L, Griesinger F: Therapy-associated genetic aberrations in patients treated for non-Hodgkin lymphoma. Br J Haematol; 2008 Apr;141(1):52-9
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  • [Title] Therapy-associated genetic aberrations in patients treated for non-Hodgkin lymphoma.
  • Therapy-associated myelodysplastic syndromes and acute myeloid leukaemia (t-AML/MDS) following high dose chemotherapy are significant problems, with a cumulative incidence of 20% or more in myeloablative treatment regimen.
  • To determine the incidence of post-therapeutic aberrations and their predictive value, we prospectively investigated 316 samples of 95 patients with non-Hodgkin lymphoma (NHL) who were treated with intermediate and high dose chemotherapy (Arm A and B of the megaCHOEP (cyclophosphamide, doxorubicin, etoposide, vincristine, prednisolone) trial of the German High Grade NHL study group).
  • Cytogenetic analysis of 53 NHL patients after high dose therapy showed frequent chromosomal breakage.
  • None of these patients developed a t-AML/MDS during a 3-year clinical follow up period.
  • We concluded that the high incidence of genetic aberrations reflected a dose-dependent, transient therapy-induced genetic damage which is not predictive of a t-AML/MDS.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / adverse effects. Chromosome Aberrations / drug effects. Lymphoma, Non-Hodgkin / drug therapy
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Cyclophosphamide / therapeutic use. Dose-Response Relationship, Drug. Doxorubicin / therapeutic use. Etoposide / therapeutic use. Follow-Up Studies. Humans. Leukemia, Myeloid, Acute / chemically induced. Middle Aged. Prednisolone / therapeutic use. Prognosis. Prospective Studies. Reverse Transcriptase Polymerase Chain Reaction / methods. Translocation, Genetic. Vincristine / therapeutic use


77. Ceschel S, Casotto V, Valsecchi MG, Tamaro P, Jankovic M, Hanau G, Fossati F, Pillon M, Rondelli R, Sandri A, Silvestri D, Haupt R, Cuttini M: Survival after relapse in children with solid tumors: a follow-up study from the Italian off-therapy registry. Pediatr Blood Cancer; 2006 Oct 15;47(5):560-6
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  • OBJECTIVE: To describe the long-term outcome of children treated for a solid tumor who relapsed after the elective end of therapy, and to explore factors associated with survival.
  • METHODS: All patients with the selected diagnoses-Hodgkin disease (HD), neuroblastoma (NB), tumor of the central nervous system (CNS), Wilms tumor (WT), or soft tissue sarcoma (STS)-enrolled in the Italian Pediatric Off-Therapy Registry in the period 1980-1998 were evaluated.
  • There were significant differences according to the original diagnosis, with patients with HD doing better, and those with NB, CNS, and STS worse.
  • [MeSH-major] Hodgkin Disease / diagnosis. Nervous System Neoplasms / diagnosis. Neuroblastoma / diagnosis. Registries. Sarcoma / diagnosis. Wilms Tumor / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Cohort Studies. Disease-Free Survival. Female. Follow-Up Studies. Humans. Infant. Infant, Newborn. Italy. Male. Prognosis. Recurrence. Risk Factors. Stem Cell Transplantation. Survival Rate. Transplantation, Homologous. Treatment Outcome


78. Long JM: Treatment approaches and nursing applications for non-Hodgkin lymphoma. Clin J Oncol Nurs; 2007 Feb;11(1 Suppl):13-21
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  • [Title] Treatment approaches and nursing applications for non-Hodgkin lymphoma.
  • Non-Hodgkin lymphoma (NHL), a malignancy that manifests in the lymphatic system, is one of the most commonly occurring hematologic disease types in the United States and other Westernized countries.
  • NHL is divided into a range of subtypes with differing clinical features and outcomes.
  • Depending on the type of NHL and the patient's overall clinical presentation, treatment varies from systemic combined chemotherapy regimens with or without immunotherapy, radioimmunotherapy, and transplants to investigational options.
  • Oncology nurses play a vital role in implementing successful treatment and management of patients with NHL as oncology care moves into an era of novel targeted therapies.
  • [MeSH-major] Lymphoma, Non-Hodgkin / nursing. Lymphoma, Non-Hodgkin / therapy

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  • (PMID = 17471823.001).
  • [ISSN] 1092-1095
  • [Journal-full-title] Clinical journal of oncology nursing
  • [ISO-abbreviation] Clin J Oncol Nurs
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Protease Inhibitors; 0 / Proteasome Inhibitors
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79. Krishnan A, Molina A, Zaia J, Smith D, Vasquez D, Kogut N, Falk PM, Rosenthal J, Alvarnas J, Forman SJ: Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas. Blood; 2005 Jan 15;105(2):874-8
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  • [Title] Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas.
  • The treatment of HIV-associated lymphoma has changed since the widespread use of highly active antiretroviral therapy.
  • This has led to higher response rates in patients with HIV-associated Hodgkin disease (HD) or non-Hodgkin lymphoma (NHL) treated with chemotherapy in conjunction with antiretroviral therapy.
  • However, for patients with refractory or relapsed disease, salvage chemotherapy still offers little chance of long-term survival.
  • In the non-HIV setting, patients with relapsed Hodgkin disease (HD) or non-Hodgkin lymphoma (NHL) have a better chance of long-term remission with high-dose chemotherapy with autologous stem cell rescue (ASCT) compared with conventional salvage chemotherapy.
  • Furthermore, similar engraftment to the non-HIV setting and low infectious risks have been observed.
  • With long-term follow-up we demonstrate that ASCT can lead to an 85% progression-free survival, which suggests that this approach may be potentially curative in select patients with relapsed HIV-associated HD or NHL.
  • [MeSH-major] Lymphoma, AIDS-Related / therapy. Stem Cell Transplantation
  • [MeSH-minor] Adolescent. Adult. Aged. CD4 Lymphocyte Count. Child. Disease-Free Survival. Follow-Up Studies. Humans. Middle Aged. Recurrence. Remission Induction. Risk Factors. Transplantation, Autologous

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  • (PMID = 15388574.001).
  • [ISSN] 0006-4971
  • [Journal-full-title] Blood
  • [ISO-abbreviation] Blood
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI38592; United States / NCI NIH HHS / CA / CA30206; United States / NCI NIH HHS / CA / CA33572
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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80. Thomas J, Rigden DJ, Cronan JE: Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family. Biochemistry; 2007 Jan 9;46(1):129-36
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  • [Title] Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family.
  • AcpH requires Mn2+ for activity, and thus, we focused on the metal binding ligands in order to locate the active site.
  • Bioinformatic investigations indicated that AcpH and its homologues were weakly related to a phosphodiesterase of known structure, the hydrolyase domain of the bifunctional bacterial protein, SpoT, suggesting that AcpH is a member of the HD family of phosphatases/ phosphodiesterases despite lacking the characteristic histidine of the motif.
  • These were then tested by site-directed mutagenesis.
  • We conclude that AcpH is a member of the HD protein family despite the lack of the signature histidine residue.
  • [MeSH-minor] Amino Acid Sequence. Binding Sites. Histidine / chemistry. Histidine / metabolism. Ligands. Manganese / metabolism. Models, Molecular. Molecular Sequence Data. Mutagenesis, Site-Directed. Protein Structure, Tertiary. Sequence Alignment

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  • (PMID = 17198382.001).
  • [ISSN] 0006-2960
  • [Journal-full-title] Biochemistry
  • [ISO-abbreviation] Biochemistry
  • [Language] eng
  • [Grant] United States / NIAID NIH HHS / AI / AI15650
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Escherichia coli Proteins; 0 / Ligands; 42Z2K6ZL8P / Manganese; 4QD397987E / Histidine; EC 3.1.4.- / Phosphoric Diester Hydrolases; EC 3.1.4.14 / AcpH protein, E coli
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81. AIRTUM Working Group: Italian cancer figures, report 2009: Cancer trend (1998-2005). Epidemiol Prev; 2009 Jul-Oct;33(4-5 Suppl 1):1-168
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  • Specific chapters are devoted to long-term trends (1986-2005), differences among age-groups, and international comparisons.
  • Mortality significantly decreased in both sexes for stomach cancer, rectum cancer, liver cancer, and Hodgkin lymphoma.
  • Incidence for all cancers together (except non-melanoma skin cancers) increased among men (APC +0.3) and remained stable among women.
  • Cancer sites which showed increasing incidence were thyroid and melanoma in both sexes, colon, testis, soft tissue among men, and lung and Hodgkin lymphoma among women.
  • For several cancer sites incidence decreased, e.g., stomach and Kaposi sarcoma (men and women), upper aerodigestive tract, oesophagus, lung, urinary bladder, myeloma and leukaemia (men), gallbladder, cervix uteri and ovary (women).

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  • (PMID = 20124636.001).
  • [ISSN] 1120-9763
  • [Journal-full-title] Epidemiologia e prevenzione
  • [ISO-abbreviation] Epidemiol Prev
  • [Language] eng; ita
  • [Publication-type] Journal Article
  • [Publication-country] Italy
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82. Engert A, Ballova V, Haverkamp H, Pfistner B, Josting A, Dühmke E, Müller-Hermelink K, Diehl V, German Hodgkin's Study Group: Hodgkin's lymphoma in elderly patients: a comprehensive retrospective analysis from the German Hodgkin's Study Group. J Clin Oncol; 2005 Aug 1;23(22):5052-60
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  • [Title] Hodgkin's lymphoma in elderly patients: a comprehensive retrospective analysis from the German Hodgkin's Study Group.
  • PURPOSE: With improved prognosis for patients with Hodgkin's lymphoma (HL), interest increasingly focuses on high-risk groups such as elderly patients.
  • We thus performed a retrospective analysis using the German Hodgkin's Study Group (GHSG) database to determine clinical risk factors, course of treatment, and outcome in elderly HL patients in comparison with younger adults.
  • RESULTS: Elderly patients more often had mixed cellularity subtype, "B" symptoms, elevated erythrocyte sedimentation rate, and poorer performance status.
  • Less frequently observed were nodular sclerosis subtype, large mediastinal mass, and bulky disease.
  • As a result, significantly fewer elderly patients received the intended full chemotherapy dose (75% v 91%).
  • The survival analysis showed a significantly poorer treatment outcome for elderly patients in terms of 5-year OS (65% v 90%), FFTF (60% v 80%), and HL-specific FFTF (73% v 82%).
  • CONCLUSION: Elderly patients have a poorer risk profile compared with younger HL patients and experience more severe treatment-associated toxicity.
  • Higher mortality during treatment as well as lower dose-intensity are the major factors explaining the poorer overall outcome of elderly HL patients.
  • [MeSH-major] Aging. Hodgkin Disease / drug therapy. Hodgkin Disease / radiotherapy

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  • (PMID = 15955904.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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83. Chandra D, Ewton A, Baker K: Hodgkin's disease presenting with osseous involvement. Am J Hematol; 2006 Jul;81(7):550-1
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  • [Title] Hodgkin's disease presenting with osseous involvement.
  • [MeSH-major] Bone Neoplasms / pathology. Hodgkin Disease / pathology

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  • (PMID = 16755566.001).
  • [ISSN] 0361-8609
  • [Journal-full-title] American journal of hematology
  • [ISO-abbreviation] Am. J. Hematol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 5V9KLZ54CY / Vinblastine; 7GR28W0FJI / Dacarbazine; 80168379AG / Doxorubicin; ABVD protocol
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84. van der Putten RF, te Velthuis H, Aarden LA, ten Cate H, Glatz JF, Hermens WT: High-affinity antibodies in a new immunoassay for plasma tissue factor: reduction in apparent intra-individual variation. Clin Chem Lab Med; 2005;43(12):1386-91
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  • Tissue factor was also measured in three successive plasma samples from 43 patients with type 2 diabetes mellitus.

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  • (PMID = 16309378.001).
  • [ISSN] 1434-6621
  • [Journal-full-title] Clinical chemistry and laboratory medicine
  • [ISO-abbreviation] Clin. Chem. Lab. Med.
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 9035-58-9 / Thromboplastin
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85. Briazzhikova TS, Iurlova TI: [Content of ceruloplasmin and immunoglobulins of the main classes in the blood sera of patients with herpes virus infection]. Zh Mikrobiol Epidemiol Immunobiol; 2005 May-Jun;(3):97-9
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  • [Title] [Content of ceruloplasmin and immunoglobulins of the main classes in the blood sera of patients with herpes virus infection].
  • In 35 patients with herpes virus infection (males and females aged 25 to 45 years) the content of ceruloplasmin and immunoglobulins of the main classes in the blood sera and the content of IgA in saliva at the stages of exacerbation and remission were evaluated.
  • For control, a group of 35 healthy donors of the same ages were used.
  • In patients with relapsing herpes virus infection even at the period of remission reliably higher levels of ceruloplasmin and immunoglobulins of the main classes were registered in comparison with those in the group of healthy donors.
  • This was indicative of the fact that constant antigenic load caused by virus persistence and, in our opinion, could be regarded as a sign of unfavorable prognosis.
  • At the periods of exacerbation a reliable increased level of secretory IgA was registered in a group of patients with rare relapses of herpes virus infection in comparison with a group of patients with frequent relapses, which showed that patients with rare relapses had a better immune response.
  • [MeSH-major] Ceruloplasmin / analysis. Herpes Simplex / immunology. Herpes Simplex / metabolism. Immunoglobulins / blood
  • [MeSH-minor] Adult. Biomarkers / analysis. Female. Humans. Immunoglobulin A / analysis. Male. Middle Aged. Recurrence. Saliva / immunology

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  • (PMID = 16028529.001).
  • [ISSN] 0372-9311
  • [Journal-full-title] Zhurnal mikrobiologii, epidemiologii, i immunobiologii
  • [ISO-abbreviation] Zh. Mikrobiol. Epidemiol. Immunobiol.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Immunoglobulin A; 0 / Immunoglobulins; EC 1.16.3.1 / Ceruloplasmin
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86. Omodei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, Frigeri F, Mancuso P, De Chiara A, Pinto A, Casola S, Simeone A: Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma. Am J Pathol; 2009 Dec;175(6):2609-17
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  • [Title] Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma.
  • Here, we investigated OTX1 and OTX2 expression in Non-Hodgkin Lymphoma (NHL) and multiple myeloma.
  • OTX1 expression was activated in 94% of diffuse large B-cell lymphomas, in all Burkitt lymphomas, and in 90% of high-grade follicular lymphomas.
  • OTX1 was undetectable in precursor-B lymphoblastic lymphoma, chronic lymphocytic leukemia, and in most marginal zone and mantle cell lymphomas and multiple myeloma.
  • [MeSH-major] B-Lymphocyte Subsets / metabolism. B-Lymphocytes / metabolism. Biomarkers, Tumor / analysis. Germinal Center / metabolism. Lymphoma, Non-Hodgkin / metabolism. Otx Transcription Factors / biosynthesis

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  • (PMID = 19893048.001).
  • [ISSN] 1525-2191
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / OTX1 protein, human; 0 / OTX2 protein, human; 0 / Otx Transcription Factors
  • [Other-IDs] NLM/ PMC2789631
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87. Gerecitano J, Goy A, Wright J, MacGregor-Cortelli B, Neylon E, Gonen M, Esseltine D, Boral A, Schenkein D, Busam K, Teruya-Feldstein J, Sachs D, O'Connor OA: Drug-induced cutaneous vasculitis in patients with non-Hodgkin lymphoma treated with the novel proteasome inhibitor bortezomib: a possible surrogate marker of response? Br J Haematol; 2006 Aug;134(4):391-8
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  • [Title] Drug-induced cutaneous vasculitis in patients with non-Hodgkin lymphoma treated with the novel proteasome inhibitor bortezomib: a possible surrogate marker of response?
  • Based on three phase II studies of bortezomib in patients with non-Hodgkin lymphoma (140 assessable patients), we identified 26 patients who developed a unique erythematous maculopapular rash during treatment, six of whom underwent cutaneous biopsy.
  • Punch biopsy in six patients revealed a perivascular lymphocytic infiltrate without evidence of lymphoma, consistent with a non-necrotising cutaneous vasculitis.
  • The odds ratio for response given the development of a rash was 4.6 (95% CI, 1.7-12.4, P = 0.001).
  • Unlike classic hypersensitivity type reactions, this vasculitic rash may not necessarily prompt cessation of drug.
  • In fact, the development of an isolated cutaneous vasculitis may portend a better clinical response to bortezomib in some patients.
  • [MeSH-major] Boronic Acids / adverse effects. Drug Hypersensitivity. Lymphoma, Non-Hodgkin / drug therapy. Protease Inhibitors / adverse effects. Pyrazines / adverse effects. Skin Diseases, Vascular / chemically induced

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  • (PMID = 16882131.001).
  • [ISSN] 0007-1048
  • [Journal-full-title] British journal of haematology
  • [ISO-abbreviation] Br. J. Haematol.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / T32 CA 09207; United States / NCI NIH HHS / CA / U01 CA 69913
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Boronic Acids; 0 / Protease Inhibitors; 0 / Pyrazines; 69G8BD63PP / Bortezomib
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88. Koutros S, Holford TR, Hahn T, Lantos PM, McCarthy PL Jr, Risch HA, Swede H: Excess diagnosis of non-Hodgkin's lymphoma during spring in the USA. Leuk Lymphoma; 2007 Feb;48(2):357-66
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  • [Title] Excess diagnosis of non-Hodgkin's lymphoma during spring in the USA.
  • Moderately increased incidence rates have been observed during the spring for leukemias and Hodgkin's disease but few studies have been conducted of non-Hodgkin's lymphoma (NHL).
  • B-cell origin subtype, but not T-cell/NK, was diagnosed more frequently in March.
  • Controlling for age, sex, geographical location, and diagnosis year, multivariate Poisson regression revealed peaks in both March and April (P < 0.0001).
  • [MeSH-major] Lymphoma, Non-Hodgkin / diagnosis. Seasons

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  • [CommentIn] Leuk Lymphoma. 2007 Feb;48(2):223-4 [17325879.001]
  • (PMID = 17325897.001).
  • [ISSN] 1042-8194
  • [Journal-full-title] Leukemia & lymphoma
  • [ISO-abbreviation] Leuk. Lymphoma
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / N01-CN-67005; United States / NCI NIH HHS / CA / R25 CA47883
  • [Publication-type] Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
  • [Publication-country] England
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89. Ilegems M, Douet V, Meylan-Bettex M, Uyttewaal M, Brand L, Bowman JL, Stieger PA: Interplay of auxin, KANADI and Class III HD-ZIP transcription factors in vascular tissue formation. Development; 2010 Mar;137(6):975-84
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  • [Title] Interplay of auxin, KANADI and Class III HD-ZIP transcription factors in vascular tissue formation.
  • Class III HD-ZIP and KANADI gene family members have complementary expression patterns in the vasculature and their gain-of-function and loss-of-function mutants have complementary vascular phenotypes.
  • We have analyzed the vasculature of plants that have altered expression levels of Class III HD-ZIP and KANADI transcription factors in provascular cells.
  • Removal of either KANADI or Class III HD-ZIP expression in procambium cells led to a wider distribution of auxin in internal tissues, to an excess of procambium cell recruitment and to increased cambium activity.
  • Ectopic expression of Class III HD-ZIP genes promoted xylem differentiation.
  • We propose that Class III HD-ZIP and KANADI transcription factors control cambium activity: KANADI proteins by acting on auxin transport, and Class III HD-ZIP proteins by promoting axial cell elongation and xylem differentiation.

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  • (PMID = 20179097.001).
  • [ISSN] 1477-9129
  • [Journal-full-title] Development (Cambridge, England)
  • [ISO-abbreviation] Development
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Arabidopsis Proteins; 0 / Homeodomain Proteins; 0 / Indoleacetic Acids; 0 / KANADI protein, Arabidopsis; 0 / Plant Growth Regulators; 0 / Transcription Factors
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90. Alfarano C, Sartiani L, Nediani C, Mannucci E, Mugelli A, Cerbai E, Raimondi L: Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells). Br J Pharmacol; 2008 Mar;153(5):907-14
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  • [Title] Functional coupling of angiotensin II type 1 receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes (HL-1 cells).
  • To determine whether angiotensin II increases insulin resistance in cardiomyocytes, we studied the effect of angiotensin II on basal and insulin-stimulated transport rate of energy substrates in immortalized cardiomyocytes (HL-1 cells).
  • EXPERIMENTAL APPROACH: Glucose and palmitic acid uptakes were measured using [(3)H]2-deoxy-D-glucose and [(14)C]palmitic acid, respectively, in cells exposed or not exposed to angiotensin II (100 nM), angiotensin II plus irbesartan or PD123319, type 1 and 2 receptor antagonists, or PD98059, an inhibitor of ERK1/2 activation.
  • Type 1 receptor levels were measured by western blot analysis.
  • KEY RESULTS: Basal uptakes of glucose and palmitic acid by HL-1 cells (0.37+/-0.07 and 7.31+/-0.22 pmol per 10(4)cells per min, respectively) were both stimulated by 100 nM insulin (+91 and +64%, respectively).
  • Our results suggest a further mechanism for the cardiovascular protection offered by the angiotensin II type 1 receptor blockers.
  • [MeSH-major] Angiotensin II / pharmacology. Insulin / metabolism. Insulin Resistance. Myocytes, Cardiac / metabolism. Receptor, Angiotensin, Type 1 / drug effects
  • [MeSH-minor] Angiotensin II Type 1 Receptor Blockers / pharmacology. Animals. Cell Line. Cell Survival / drug effects. Glucose / metabolism. Hypertrophy. Mice. Palmitic Acid / metabolism

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  • (PMID = 17982475.001).
  • [ISSN] 0007-1188
  • [Journal-full-title] British journal of pharmacology
  • [ISO-abbreviation] Br. J. Pharmacol.
  • [Language] eng
  • [Grant] Italy / Telethon / / GGP05093
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiotensin II Type 1 Receptor Blockers; 0 / Insulin; 0 / Receptor, Angiotensin, Type 1; 11128-99-7 / Angiotensin II; 2V16EO95H1 / Palmitic Acid; IY9XDZ35W2 / Glucose
  • [Other-IDs] NLM/ PMC2267260
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91. Davis QG, Paulino AC, Miller R, Ting JY: Mantle fields in the era of dynamic multileaf collimation: field shaping and electronic tissue compensation. Med Dosim; 2006;31(3):179-83
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  • Mantle field radiotherapy for Hodgkin's disease is complicated by significant dose gradient (up to 10-20%) across the large fields required.
  • Many different strategies of tissue compensation have been investigated, including custom physical compensators to provide better dose distributions.
  • We present a method using dynamic multileaf collimator (dMLC) fluence modulation to simultaneously shape the treatment field and give homogeneous dose at depth throughout the classic mantle field.
  • Five patients were treated for early-stage Hodgkin's disease with a conventional anterior-posterior-posterior-anterior (AP-PA) mantle field.
  • An AP-PA dynamic MLC beam-shaped and dose-compensated plan was created for each, and compared with the conventional blocked plan.
  • Nine dose points were calculated at midplane in each plan.
  • Chamber measurements were taken to confirm accurate dMLC delivery of the planned doses.
  • The mean dose per fraction, relative to a central axis dose of 1.8 Gy, was increased in the conventional plans compared with the dMLC plans in the right (R) neck, left (L) neck, R supraclavicular, L supraclavicular, and L axillary points.
  • Measurements showed excellent agreement between planned doses and delivered doses, with less than 2% in-field variation.
  • Dynamic MLC fluence modulation was used to effectively deliver a mantle field that is both shape- and electronically-dose-compensated with sliding window MLC.
  • Homogeneity was significantly improved throughout the treatment field, and measurements confirmed accurate dose delivery using this technique.
  • [MeSH-major] Hodgkin Disease / radiotherapy
  • [MeSH-minor] Dose-Response Relationship, Radiation. Humans. Radiotherapy Dosage. Radiotherapy Planning, Computer-Assisted. Radiotherapy, Conformal

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  • (PMID = 16905447.001).
  • [ISSN] 0958-3947
  • [Journal-full-title] Medical dosimetry : official journal of the American Association of Medical Dosimetrists
  • [ISO-abbreviation] Med Dosim
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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92. Wörmke S, Mackowski S, Brotosudarmo TH, Jung C, Zumbusch A, Ehrl M, Scheer H, Hofmann E, Hiller RG, Bräuchle C: Monitoring fluorescence of individual chromophores in peridinin-chlorophyll-protein complex using single molecule spectroscopy. Biochim Biophys Acta; 2007 Jul;1767(7):956-64
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  • Single molecule spectroscopy experiments are reported for native peridinin-chlorophyll a-protein (PCP) complexes, and three reconstituted light-harvesting systems, where an N-terminal construct of native PCP from Amphidinium carterae has been reconstituted with chlorophyll (Chl) mixtures: with Chl a, with Chl b and with both Chl a and Chl b.
  • Using laser excitation into peridinin (Per) absorption band we take advantage of sub-picosecond energy transfer from Per to Chl that is order of magnitude faster than the Förster energy transfer between the Chl molecules to independently populate each Chl in the complex.
  • The results indicate that reconstituted PCP complexes contain only two Chl molecules, so that they are spectroscopically equivalent to monomers of native-trimeric-PCP and do not aggregate further.
  • Through removal of ensemble averaging we are able to observe for single reconstituted PCP complexes two clear steps in fluorescence intensity timetraces attributed to subsequent bleaching of the two Chl molecules.
  • Importantly, the bleaching of the first Chl affects neither the energy nor the intensity of the emission of the second one.
  • Since in strongly interacting systems Chl is a very efficient quencher of the fluorescence, this behavior implies that the two fluorescing Chls within a PCP monomer interact very weakly with each other which makes it possible to independently monitor the fluorescence of each individual chromophore in the complex.
  • We apply this property, which distinguishes PCP from other light-harvesting systems, to measure the distribution of the energy splitting between two chemically identical Chl a molecules contained in the PCP monomer that reaches 280 cm(-1).
  • Most PCP complexes reconstituted with both Chl a and Chl b show two emission lines, whose wavelengths correspond to the fluorescence of Chl a and Chl b.

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  • (PMID = 17572378.001).
  • [ISSN] 0006-3002
  • [Journal-full-title] Biochimica et biophysica acta
  • [ISO-abbreviation] Biochim. Biophys. Acta
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Light-Harvesting Protein Complexes; 0 / Protozoan Proteins; 1406-65-1 / Chlorophyll; 33281-81-1 / peridinin; 36-88-4 / Carotenoids; 5712ZB110R / chlorophyll b; YF5Q9EJC8Y / chlorophyll a
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93. Mihailov G, Ganeva P, Vassileva N, Guenova M, Balacenko G, Toshkov S, Hodjadjik D: Secondary acute myeloid leukemia early after therapy for Hodgkin's disease--a case report. J BUON; 2007 Jul-Sep;12(3):403-6
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  • [Title] Secondary acute myeloid leukemia early after therapy for Hodgkin's disease--a case report.
  • A case of acute myeloid leukemia (AML) after successful therapy for Hodgkin's disease (HD) is reported.
  • The patient was diagnosed with stage IIB HD at the age of 25.
  • Knowing that the prognosis of patients with secondary AML (sAML) after primary HD is poor we decided to perform autologous peripheral stem cells' transplantation.
  • [MeSH-major] Hematopoietic Stem Cell Transplantation. Leukemia, Myeloid, Acute / diagnosis. Leukemia, Myeloid, Acute / surgery. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / surgery
  • [MeSH-minor] Adult. Female. Hodgkin Disease / drug therapy. Hodgkin Disease / radiotherapy. Hodgkin Disease / therapy. Humans. Treatment Outcome

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  • (PMID = 17918297.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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94. Podol'skiĭ PN, Datsenko PV, Pan'shin GA, Sotnikov VM, Mel'nik IuD, Ivashin AV, Bozhenko VK: [Multivariate analysis of risk of cardiac complications in Hodgkin's lymphoma]. Vopr Onkol; 2009;55(4):447-50
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  • [Title] [Multivariate analysis of risk of cardiac complications in Hodgkin's lymphoma].
  • A computer database was created to take care of a wide range of protocols for combined treatment of Hodgkin's disease stage I-IV (n=1,573).
  • Our approach might promote individualization of prognosis as far as cardiac complications involved in Hodgkin's lymphoma are concerned.
  • [MeSH-major] Heart / radiation effects. Heart Diseases / etiology. Hodgkin Disease / radiotherapy


95. Buyukpamukçu M, Varan A, Aydin B, Kale G, Akata D, Yalçin B, Akyuz C, Kutluk T: Renal involvement of non-Hodgkin's lymphoma and its prognostic effect in childhood. Nephron Clin Pract; 2005;100(3):c86-91
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  • [Title] Renal involvement of non-Hodgkin's lymphoma and its prognostic effect in childhood.
  • OBJECTIVE: To evaluate renal involvement in childhood lymphoma and define its prognostic effects.
  • PATIENTS AND METHODS: One hundred and four patients with non-Hodgkin's lymphoma and renal involvement on admission to a single center between 1972 and 2003 were evaluated retrospectively.
  • The renal infiltration pattern was nodular in 62 patients (59.6%) and diffuse in 40 patients (38.5%).
  • CONCLUSION: Impaired renal function is a poor prognostic factor for non-Hodgkin's lymphoma.
  • [MeSH-major] Kidney / pathology. Lymphoma, Non-Hodgkin / pathology

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  • (PMID = 15824512.001).
  • [ISSN] 1660-2110
  • [Journal-full-title] Nephron. Clinical practice
  • [ISO-abbreviation] Nephron Clin Pract
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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96. Klabusay M, Lysák D, Hrabcáková V, Navrátil M, Coupek P, Mayer J: [Effect of growth factor on the phenotype of subpopulations and on the kinetics of CD34+ cells in the peripheral blood and in grafts of peripheral stem cells in patients with non-Hodgkin's lymphoma indicated for autologous peripheral blood stem cell transplantation]. Cas Lek Cesk; 2008;147(6):319-24
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  • [Title] [Effect of growth factor on the phenotype of subpopulations and on the kinetics of CD34+ cells in the peripheral blood and in grafts of peripheral stem cells in patients with non-Hodgkin's lymphoma indicated for autologous peripheral blood stem cell transplantation].
  • [Transliterated title] Vliv typu růstového faktoru na fenotyp subpopulací a kinetiku CD34+ bunek v periferní krvi a stepech periferních kmenových bunek pacientů s non-hodgkinskými lymfomy indikovaných k autologní transplantaci krvetvorby.
  • BACKGROUND: Peripheral blood stem cells are the preferred source for transplantation of hematopoiesis in patients with non-Hodgkin's lymphoma.
  • Authors analyzed the effect of two growth factors (leridistim and filgrastim) on the kinetics and phenotype of CD34+ cells in patients with non-Hodgkin's lymphoma indicated for autologous peripheral blood stem cell transplantation.
  • Statistically significant differences in expression of lineage-committed antigens between growth factors were found (CD3, CD5--T-lineage, CD56 NK-lineage, CD20 for B-lineage, p < 0.05), as well as for lineage non-specific antigens (CD38, p < 0.05 and CD54, p < 0.01).
  • [MeSH-major] Antigens, CD34 / analysis. Granulocyte Colony-Stimulating Factor / pharmacology. Hematopoietic Stem Cell Mobilization. Interleukin-3 / pharmacology. Lymphoma, Non-Hodgkin / therapy. Peripheral Blood Stem Cell Transplantation. Recombinant Fusion Proteins / pharmacology

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  • (PMID = 18724529.001).
  • [ISSN] 0008-7335
  • [Journal-full-title] Casopís lékar̆ů c̆eských
  • [ISO-abbreviation] Cas. Lek. Cesk.
  • [Language] cze
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Czech Republic
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Interleukin-3; 0 / Recombinant Fusion Proteins; 0 / Recombinant Proteins; 143011-72-7 / Granulocyte Colony-Stimulating Factor; 193700-51-5 / leridistim; PVI5M0M1GW / Filgrastim
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97. Fuster D, Chiang S, Andreadis C, Guan L, Zhuang H, Schuster S, Alavi A: Can [18F]fluorodeoxyglucose positron emission tomography imaging complement biopsy results from the iliac crest for the detection of bone marrow involvement in patients with malignant lymphoma? Nucl Med Commun; 2006 Jan;27(1):11-5
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  • [Title] Can [18F]fluorodeoxyglucose positron emission tomography imaging complement biopsy results from the iliac crest for the detection of bone marrow involvement in patients with malignant lymphoma?
  • OBJECTIVES: To assess the usefulness of [18F]fluorodeoxyglucose positron emission tomography in the detection of bone marrow involvement in malignant lymphoma, and its impact in clinical management.
  • METHODS: One hundred and six consecutive patients with a confirmed diagnosis of lymphoma, referred for staging or restaging of Hodgkin's lymphoma (n=18) or non-Hodgkin's lymphoma (n=88), were reviewed retrospectively.
  • The assessment of bone marrow involvement by lymphoma was confirmed by histology and/or progression of bone marrow lesions in clinical follow-up.
  • Ten cases of non-Hodgkin's lymphoma and two cases of Hodgkin's lymphoma with positive positron emission tomography results and an initial negative bone marrow biopsy showed clinical progression of the bone marrow lesions and/or subsequent positive histology.
  • In seven of the 12 positive cases with negative bone marrow biopsy, positron emission tomography uptake distant from the site of the biopsy was seen.
  • In four cases of follicular lymphoma, the bone marrow biopsy was positive and the positron emission tomography scan was normal.
  • CONCLUSIONS: Positron emission tomography and bone marrow biopsy are complementary in assessing the presence of bone marrow involvement in patients with malignant lymphoma.
  • In our series, positron emission tomography was more sensitive than bone marrow biopsy in Hodgkin's and non-Hodgkin's lymphoma, except in follicular lymphoma.
  • [MeSH-major] Biopsy, Needle / methods. Bone Marrow / pathology. Bone Marrow / radionuclide imaging. Fluorodeoxyglucose F18. Ilium / pathology. Lymphoma / pathology. Lymphoma / radionuclide imaging

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  • (PMID = 16340718.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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98. Renedo RJ, Sousa MM, Pérez SF, Zabalbeascoa JR, Carro LP: Avascular necrosis of the femoral head in patients with Hodgkin's disease. Hip Int; 2010 Oct-Dec;20(4):473-81
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  • [Title] Avascular necrosis of the femoral head in patients with Hodgkin's disease.
  • Avascular necrosis of the femoral head (ANFH) is a rare complication that may occur in patients diagnosed with Hodgkin's Disease (HD), as a result of treatment.
  • A review was made of 315 cases of HD treated with systemic chemotherapy associated with high doses of steroids and radiation therapy and 18 patients (5.71%) were found to have developed ANFH during treatment.
  • The mean follow-up time for chemotherapy was 40 months (range 20-110 months) with an average dose of prednisone of 8.45 g (range 3.20 - 18.50).
  • The clinical outcomes (time to postoperative pain, time to radiological failure, and time to arthroplasty from the forage) following surgical management using the forage-biopsy technique with and without internal electrostimulation (IES) were recorded.
  • We observed that treatment with Forage + IES was better than simple Forage in stages below III in patients with Hodgkin's Disease.
  • [MeSH-major] Femur Head Necrosis / pathology. Hodgkin Disease / pathology

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  • (PMID = 21157752.001).
  • [ISSN] 1724-6067
  • [Journal-full-title] Hip international : the journal of clinical and experimental research on hip pathology and therapy
  • [ISO-abbreviation] Hip Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Glucocorticoids; VB0R961HZT / Prednisone
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99. Kornblit B, Masmas T, Madsen HO, Ryder LP, Svejgaard A, Jakobsen B, Sengeløv H, Olesen G, Heilmann C, Dickmeiss E, Petersen SL, Vindeløv L: Haematopoietic cell transplantation with non-myeloablative conditioning in Denmark: disease-specific outcome, complications and hospitalization requirements of the first 100 transplants. Bone Marrow Transplant; 2008 May;41(10):851-9
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  • [Title] Haematopoietic cell transplantation with non-myeloablative conditioning in Denmark: disease-specific outcome, complications and hospitalization requirements of the first 100 transplants.
  • We analysed the outcome and hospitalization requirements of the first 100 patients (Hodgkin's disease (HD), N=13; multiple myeloma (MM), N=14; CLL, N=12; non-Hodgkin's lymphoma (NHL), N=17; myelodysplastic syndrome (MDS), N=18; AML, N=24 and CML, N=2) treated in Denmark with haematopoietic cell transplantation after non-myeloablative conditioning with TBI 2 Gy+/-fludarabine.
  • Patients with MM, HD and MDS and a history of > or =5% blasts had a less favourable outcome with a PFS of 19-38% (P=0.001).
  • [MeSH-minor] Adult. Aged. Denmark / epidemiology. Female. Graft vs Host Disease / epidemiology. Hodgkin Disease / therapy. Hospitalization / statistics & numerical data. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Leukemia, Myeloid, Acute / therapy. Lymphoma, Non-Hodgkin / therapy. Male. Middle Aged. Multiple Myeloma / therapy. Myelodysplastic Syndromes / therapy. Outpatient Clinics, Hospital / utilization. Treatment Outcome. Vidarabine / analogs & derivatives. Vidarabine / therapeutic use. Whole-Body Irradiation

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  • (PMID = 18246114.001).
  • [ISSN] 0268-3369
  • [Journal-full-title] Bone marrow transplantation
  • [ISO-abbreviation] Bone Marrow Transplant.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] FA2DM6879K / Vidarabine; P2K93U8740 / fludarabine
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100. Chan K, Behling E, Strayer DS, Kocher WS, Dessain SK: Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case report. J Med Case Rep; 2008;2:367
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case report.
  • She was found to have stage IV classical Hodgkin lymphoma, in addition to Epstein-Barr virus and cytomegalovirus viremia.
  • CONCLUSION: Fulminant hemophagocytic lymphohistiocytosis may follow a prodromal phase that possesses features suggestive of a chronic form of hemophagocytic lymphohistiocytosis, but which may also resemble immune cytopenias of other causes.
  • A diagnosis of hemophagocytic lymphohistiocytosis should be considered in the setting of chronic pancytopenia.

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  • (PMID = 19055804.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2613409
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