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1. Serletis D, Parkin P, Bouffet E, Shroff M, Drake JM, Rutka JT: Massive plexiform neurofibromas in childhood: natural history and management issues. J Neurosurg; 2007 May;106(5 Suppl):363-7
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  • [Title] Massive plexiform neurofibromas in childhood: natural history and management issues.
  • OBJECT: The authors review their experience with massive plexiform neurofibromas (PNs) in patients with pediatric neurofibromatosis Type 1 (NF1) to better characterize the natural history and management of these complex lesions.
  • These patients attended routine follow-up examinations conducted by a number of specialists, and serial neuroimaging studies were obtained to monitor disease progression.
  • The most common presenting feature of PN was that of a painful, expanding lesion.
  • With respect to management, two patients were simply observed, undergoing serial neuroimaging studies; two patients underwent biopsy sampling of their plexiform lesions; two patients underwent attempted medical treatment (farnesyl transferase inhibitor, R11577, and cyclophosphamide chemotherapy); and three patients required surgical debulking of their PNs because the massive growth of these tumors caused functional compromise.
  • Nevertheless, patients with massive PNs will benefit from close surveillance by a team of specialists to monitor for ongoing disease progression.
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Antineoplastic Agents, Alkylating / therapeutic use. Child. Child, Preschool. Cyclophosphamide / therapeutic use. Humans. Male. Neoplasms, Second Primary / diagnosis. Neoplasms, Second Primary / therapy. Neurosurgical Procedures. Pain / etiology. Quinolones / therapeutic use. Respiration Disorders / etiology. Respiration Disorders / mortality. Retrospective Studies

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  • (PMID = 17566202.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Alkylating; 0 / Quinolones; 192185-72-1 / tipifarnib; 8N3DW7272P / Cyclophosphamide
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2. Bottillo I, Ahlquist T, Brekke H, Danielsen SA, van den Berg E, Mertens F, Lothe RA, Dallapiccola B: Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours. J Pathol; 2009 Apr;217(5):693-701
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  • [Title] Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours.
  • Malignant peripheral nerve sheath tumours (MPNSTs) are a malignancy occurring with increased frequency in patients with neurofibromatosis type 1 (NF1).
  • Somatic NF1 mutations were found in 10/25 (40%) NF1-associated MPNSTs, in 3/7 (43%) neurofibromas, and in 9/22 (41%) sporadic MPNSTs.
  • Two NF1-associated and 13 sporadic MPNSTs did not show any NF1 mutation.
  • [MeSH-major] Germ-Line Mutation. Nerve Sheath Neoplasms / genetics. Neurofibromatosis 1 / genetics
  • [MeSH-minor] Adolescent. Adult. Aged. Child. Chromatography, High Pressure Liquid / methods. DNA, Neoplasm / genetics. Female. Genetic Predisposition to Disease. Humans. Male. Middle Aged. Neoplasm Proteins / genetics. Point Mutation. Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins B-raf / genetics. ras Proteins / genetics

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  • (PMID = 19142971.001).
  • [ISSN] 1096-9896
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / KRAS protein, human; 0 / Neoplasm Proteins; 0 / Proto-Oncogene Proteins; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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3. Duenschede F, Bittinger F, Heintz A, Musholt T, Korenkov M, Kann P, Ewald P, Gockel I, Junginger T: Malignant and unclear histological findings in incidentalomas. Eur Surg Res; 2008;40(2):235-8
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  • BACKGROUND: The management of incidentalomas with tumor size 3 cm and larger is still under controversial discussion.
  • Indications for surgery were tumor size equal and larger than 3 cm, recurrent pain, hormone status and patients' fear of malignancy.
  • In 45 patients, the adenomas did not meet the defined criteria of malignancy.
  • Moreover, 1 schwannoma and 1 myelolipoma were removed.
  • In 1 patient, the status (size: 4.5 cm) could not be determined conclusively.
  • CONCLUSION: Hormonal activity should be determined independent of the size, and lesions with hormonal activity should be resected; in the presence of hormonally inactive masses, removal of tumors of 3 cm and larger in size is recommended.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Incidental Findings
  • [MeSH-minor] Diagnostic Techniques, Endocrine. Female. Hormones / metabolism. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed. Ultrasonography

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  • [Copyright] Copyright 2008 S. Karger AG, Basel.
  • (PMID = 18032908.001).
  • [ISSN] 1421-9921
  • [Journal-full-title] European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes
  • [ISO-abbreviation] Eur Surg Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Hormones
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4. Cai W, Kassarjian A, Bredella MA, Harris GJ, Yoshida H, Mautner VF, Wenzel R, Plotkin SR: Tumor burden in patients with neurofibromatosis types 1 and 2 and schwannomatosis: determination on whole-body MR images. Radiology; 2009 Mar;250(3):665-73
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  • [Title] Tumor burden in patients with neurofibromatosis types 1 and 2 and schwannomatosis: determination on whole-body MR images.
  • PURPOSE: To develop a three-dimensional (3D) segmentation and computerized volumetry technique for use in the assessment of neurofibromatosis and to assess the ability of this technique to aid in the calculation of tumor burden in patients with neurofibromatosis types 1 and 2 (NF1 and NF2, respectively) and schwannomatosis detected with whole-body magnetic resonance (MR) imaging.
  • Whole-body tumor burden was estimated with a 3D segmentation method (the dynamic-threshold [DT] level set method) in 29 subjects (16 with NF1, six with NF2, and seven with schwannomatosis) in whom at least one nerve sheath tumor was reliably identified on MR images.
  • Fifty tumors (25 plexiform and 25 discrete tumors) were randomly selected and subjected to manual and computerized volumetry to assess reliability.
  • Ten plexiform tumors 5 cm or larger in diameter were retrospectively selected and segmented with three initialization methods for computerized volumetry and manually contoured by three radiologists to assess repeatability.
  • RESULTS: A total of 398 nerve sheath tumors (185 plexiform and 213 discrete tumors) were identified in 29 subjects.
  • This technique can be paired with whole-body MR imaging to determine tumor burden in patients with neurofibromatosis.


5. Shuto T, Inomori S, Matsunaga S, Fujino H: Microsurgery for vestibular schwannoma after gamma knife radiosurgery. Acta Neurochir (Wien); 2008 Mar;150(3):229-34; discussion 234
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  • [Title] Microsurgery for vestibular schwannoma after gamma knife radiosurgery.
  • BACKGROUND: We evaluated the clinical characteristics of microsurgery for vestibular schwannoma (VS) after failed gamma knife radiosurgery (GKS).
  • The mean volume of tumour at GKS was 6.9 cm(3) (range, 0.5-19.7 cm(3)) and the mean prescription dose to the tumour margin was 12.3 Gy.
  • Tumour expansion involved solid enlargement in 7 patients, cystic enlargement in 3, and central necrosis in 2.
  • Identification of the facial nerve was easy in 5 operations and difficult in 7.
  • Dissection of the tumour from the facial nerve was difficult in most interventions because of severe adhesions or colour change.
  • Severe adhesions between the trigeminal nerve and the tumour was observed in 2 patients.
  • The tumour was subtotally removed except around the internal auditory canal in most patients.
  • Only one residual tumour increased in size and needed second GKS.
  • The function of the facial nerve deteriorated in 3 patients, was unchanged in 7, and improved in 2.
  • Dissection of the tumour from the facial nerve or brain stem is likely to be difficult.
  • We recommend subtotal resection without dissection of the facial nerve and tumour, because growth of the residual tumour was rare in our series.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Microsurgery / methods. Neuroma, Acoustic / surgery. Radiosurgery / methods. Vestibulocochlear Nerve Diseases / surgery
  • [MeSH-minor] Adult. Aged. Dissection / methods. Dissection / standards. Ear, Inner / anatomy & histology. Ear, Inner / pathology. Ear, Inner / surgery. Facial Nerve / pathology. Facial Nerve / physiopathology. Facial Nerve / surgery. Facial Nerve Injuries / etiology. Facial Nerve Injuries / physiopathology. Facial Nerve Injuries / prevention & control. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Neurosurgical Procedures / methods. Neurosurgical Procedures / standards. Neurosurgical Procedures / statistics & numerical data. Petrous Bone / anatomy & histology. Petrous Bone / pathology. Petrous Bone / surgery. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Postoperative Complications / prevention & control. Retrospective Studies. Treatment Failure. Treatment Outcome. Trigeminal Nerve / pathology. Trigeminal Nerve / physiopathology. Trigeminal Nerve / surgery

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  • (PMID = 18253695.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Austria
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6. Song JY, Kim SY, Park EG, Kim CJ, Kim DG, Lee HK, Park IY: Schwannoma in the retroperitoneum. J Obstet Gynaecol Res; 2007 Jun;33(3):371-5
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  • [Title] Schwannoma in the retroperitoneum.
  • Schwannoma (neurilemmoma) is a peripheral nerve sheath tumor and commonly occurs singularly on the head, neck, and trunk.
  • Giant schwannoma is rarely located on the retroperitoneum and pelvic cavity.
  • The majority of symptoms caused by the tumor are due to the effect of its mass.
  • Surgical resection is enough to treat the tumor.
  • Schwannoma is reported usually as benign, and despite incomplete resection of the tumor, the risk of recurrence and metastasis is low.
  • A schwannoma on the retroperitoneum that was preoperatively misdiagnosed as a malignant adnexal mass in a 60-year-old menopausal woman is presented, with a brief review of the literature.
  • [MeSH-major] Neurilemmoma / pathology. Retroperitoneal Neoplasms / pathology. Retroperitoneal Space / pathology

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  • (PMID = 17578370.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 19
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7. Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P: True incidence of vestibular schwannoma? Neurosurgery; 2010 Nov;67(5):1335-40; discussion 1340
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  • [Title] True incidence of vestibular schwannoma?
  • OBJECTIVE: To present updated epidemiological data on VS incidence, as well as patient age, hearing acuity, tumor size, and localization at diagnosis for the last 4 decades in an unselected population, with emphasis on developments in recent years.
  • Incidence during the period, patient sex and age, data on hearing (pure tone average and speech discrimination), and tumor size at diagnosis were retrieved from the database.
  • Mean tumor size at diagnosis decreased from 30 mm in 1979 to 10 mm in 2008, whereas hearing acuity at diagnosis has improved over the years.
  • CONCLUSION: After a steady increase over the last 4 decades, the incidence of vestibular schwannomas appears to have peaked and decreased in recent years, stabilizing at about 19 tumors per million per year.
  • Whereas the sex ratio and age at diagnosis have remained grossly unchanged over the years, hearing has improved, and tumor size has decreased considerably.

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  • (PMID = 20871439.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Choi KD, Cho HJ, Koo JW, Park SH, Kim JS: Hyperventilation-induced nystagmus in vestibular schwannoma. Neurology; 2005 Jun 28;64(12):2062
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  • [Title] Hyperventilation-induced nystagmus in vestibular schwannoma.
  • [MeSH-minor] Aged. Cochlear Nerve / pathology. Cochlear Nerve / physiopathology. Diagnosis, Differential. Female. Hearing Loss / etiology. Humans. Hyperoxia / complications. Hyperoxia / physiopathology. Magnetic Resonance Imaging. Neural Conduction / physiology. Vestibular Nerve / pathology. Vestibular Nerve / physiopathology. Vestibule, Labyrinth / physiopathology

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  • (PMID = 15985572.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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9. Surendrababu NR, Cherian SR, Janakiraman R, Walter N: Large retroperitoneal schwannoma mimicking a cystic ovarian mass in a patient with Hansen's disease. J Clin Ultrasound; 2008 Jun;36(5):318-20
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  • [Title] Large retroperitoneal schwannoma mimicking a cystic ovarian mass in a patient with Hansen's disease.
  • We present a rare case of retroperitoneal cystic schwannoma of the pelvis in a patient with Hansen's disease that mimicked an ovarian cyst.
  • Due to economic constraints and because the lesion was assumed to be of ovarian origin, the patient did not undergo any cross-sectional imaging other than sonography.
  • A cystic schwannoma was diagnosed at laparotomy.
  • [MeSH-major] Leprosy / complications. Neurilemmoma / ultrasonography. Ovarian Cysts / diagnosis. Retroperitoneal Neoplasms / ultrasonography


10. Lee SH, Hong JS, Choi JH, Chung WS: Choroidal schwannoma. Acta Ophthalmol Scand; 2005 Dec;83(6):754-6
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  • [Title] Choroidal schwannoma.
  • PURPOSE: Schwannoma is rarely encountered as an intraocular tumor arising from uveal tract.
  • We describe a case of choroidal schwannoma.
  • To further delineate the tumor, she underwent enucleation of the eyeball.
  • The tumor was examined by light microscopy, electron microscopy and immunohistochemical study.
  • RESULTS: Microscopically, the tumor was composed of a mixture of cellular solid component (Antoni A) and loose myxoid component (Antoni B).
  • Ultrastructurally, the tumor cells showed prominent, continuous basal lamina.
  • CONCLUSIONS: We enucleated the eyeball with a clinical diagnosis of choroidal amelanotic melanoma, but the tumor was finally diagnosed as schwannoma.
  • We think that currently available ancillary studies are still little value in definitely differentiating schwannoma from other choroidal tumors.
  • [MeSH-major] Choroid Neoplasms / pathology. Neurilemmoma / pathology

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  • (PMID = 16396657.001).
  • [ISSN] 1395-3907
  • [Journal-full-title] Acta ophthalmologica Scandinavica
  • [ISO-abbreviation] Acta Ophthalmol Scand
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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11. Gupta R, Sharma A, Arora R, Vijayaraghavan M: Composite phaeochromocytoma with malignant peripheral nerve sheath tumour and rhabdomyosarcomatous differentiation in a patient without von Recklinghausen disease. J Clin Pathol; 2009 Jul;62(7):659-61
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  • [Title] Composite phaeochromocytoma with malignant peripheral nerve sheath tumour and rhabdomyosarcomatous differentiation in a patient without von Recklinghausen disease.
  • The coexistence of adrenal phaeochromocytoma with a malignant Triton tumour does not appear to have been described in the available literature so far.
  • A unique case of composite phaeochromocytoma in a 26-year-old male patient, where the non-chromaffin component was a malignant Triton tumour composed of peripheral nerve sheath tumour and skeletal muscle differentiation, is reported.
  • Since the prognosis of composite phaeochromocytoma with malignant nerve sheath tumour would be determined by the nerve sheath component, recognition of this tumour is imperative.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Nerve Sheath Neoplasms / pathology. Pheochromocytoma / pathology. Rhabdomyosarcoma / pathology


12. Somefun OA, Giwa OS, Bamgboye BA, Okeke-Igbokwe II, Azeez AA: Vestibular disorders among adults in a tertiary hospital in Lagos, Nigeria. Eur Arch Otorhinolaryngol; 2010 Oct;267(10):1515-21
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  • Dizziness is not an uncommon complaint in the Otolaryngological clinics among other symptoms.
  • Peripheral vestibular disorders are common of which benign paroxysmal positional vertigo (BPPV) was seen in 29 (28.4%), Meniere's disease in 22 (21.6%), recurrent vestibulopathy in 20 (19.6%), cervical vertigo in 18 (17.6%), psychogenic vertigo in 2 (2%), vestibular schwannoma, barotraumas and drug-induced vertigo in 1 (1%), respectively, central vestibular disorders of vascular origin 2 (2%), vertebrobasilar insufficiency in 1 (1%), post-traumatic vertigo in 3 (3%) and unknown in 2 (2%).

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  • (PMID = 20464409.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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13. Paek SH, Chung HT, Jeong SS, Park CK, Kim CY, Kim JE, Kim DG, Jung HW: Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma. Cancer; 2005 Aug 1;104(3):580-90
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  • [Title] Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma.
  • BACKGROUND: To evaluate the hearing preservation rate and to determine its prognostic factors after gamma knife (GK) stereotactic radiosurgery (SRS) in patients with vestibular schwannoma, the authors used a prospective study design to analyze these patients.
  • METHODS: Between December 1997 and January 2002, 25 patients with vestibular schwannoma with serviceable hearing were enrolled in the current study.
  • The median tumor volume was 3.0 cc (0.16-9.1 cc).
  • The tumor control rate and complications were evaluated by focusing on hearing preservation and its prognostic factors.
  • RESULTS: Based on radiologic study, the tumor control rate was 92% during the median follow-up period of 45 months.
  • The trigeminal and facial nerve preservation rates were 95% and 100%, respectively.
  • [MeSH-major] Cochlear Nerve / pathology. Hearing Loss / prevention & control. Neuroma, Acoustic / surgery. Postoperative Complications / prevention & control. Radiosurgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Prospective Studies. Stereotaxic Techniques. Treatment Outcome. Tumor Burden

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  • [Copyright] (c) 2005 American Cancer Society.
  • (PMID = 15952200.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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14. Kameda K, Shono T, Hashiguchi K, Yoshida F, Sasaki T: Effect of tumor removal on tinnitus in patients with vestibular schwannoma. J Neurosurg; 2010 Jan;112(1):152-7
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  • [Title] Effect of tumor removal on tinnitus in patients with vestibular schwannoma.
  • OBJECT: Tinnitus is one of the most common symptoms in patients with vestibular schwannomas (VSs), but the effect of surgery on this symptom has not been fully evaluated.
  • The aim of this study was to define the effect on tinnitus of tumor removal, cochlear nerve resection, and useful hearing preservation in patients with VSs.
  • RESULTS: Of 242 patients, 171 (70.7%) complained of tinnitus before surgery; the symptom disappeared in 25.2%, improved in 33.3%, remained unchanged in 31.6%, and worsened in 9.9% of these cases after tumor removal.
  • In the 171 patients with preoperative tinnitus, the cochlear nerve was resected in 85 (49.7%) and preserved in 86 (50.3%), but there was no significant difference in the incidence of postoperative tinnitus between these 2 groups (p = 0.293).
  • Among those without preoperative tinnitus, the cochlear nerve was resected in 45 cases (63.4%) and tinnitus appeared postoperatively in 3 (6.7%).
  • The authors also analyzed the association between postoperative tinnitus and useful hearing preservation, but could not find any statistically significant association between the 2 factors (p = 0.153).
  • CONCLUSIONS: Tumor removal via the retrosigmoid lateral suboccipital approach may provide some chance for improvement of tinnitus in patients with VSs; however, neither cochlear nerve resection nor useful hearing preservation affects the postoperative development of tinnitus.
  • [MeSH-minor] Cochlear Nerve / surgery. Female. Hearing Disorders / etiology. Humans. Male. Middle Aged. Retrospective Studies. Severity of Illness Index. Treatment Outcome


15. French PJ, Main G, Mowle D, Smith C: A case of raised intracranial pressure due to multiple lumbar nerve root melanotic schwannomas. Br J Neurosurg; 2005 Dec;19(6):502-4
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  • [Title] A case of raised intracranial pressure due to multiple lumbar nerve root melanotic schwannomas.
  • We report a patient with multiple cranial nerve and lumbar spine nerve root melanotic schwannomas, a rare variant of schwannoma, with raised intracranial pressure.
  • [MeSH-major] Neurilemmoma / pathology. Spinal Neoplasms / pathology. Spinal Nerve Roots / pathology

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  • (PMID = 16574565.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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16. Van Herendael B, Heyman S, De Schepper AM, Gielen J, Parizel PM: Schwannoma of left ulnar nerve. JBR-BTR; 2006 May-Jun;89(3):156-7
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  • [Title] Schwannoma of left ulnar nerve.
  • [MeSH-major] Magnetic Resonance Imaging. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis. Ulnar Nerve

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  • (PMID = 16883770.001).
  • [ISSN] 0302-7430
  • [Journal-full-title] JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR)
  • [ISO-abbreviation] JBR-BTR
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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17. Ikari R, Okamoto K, Yoshida T, Johnin K, Okabe H, Okada Y: A rare case of multiple schwannomas presenting with scrotal mass: a probable case of schwannomatosis. Int J Urol; 2010 Aug;17(8):734-6
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  • In the present case, a scrotal schwannoma developed in a 66-year-old man with a history of brain tumor surgery.
  • In this regard, the present case highlights the importance of thorough history taking in patients with scrotal schwannoma.
  • [MeSH-major] Cerebellar Neoplasms / pathology. Genital Neoplasms, Male / pathology. Neoplasms, Second Primary / pathology. Neoplastic Syndromes, Hereditary / pathology. Neurilemmoma / pathology. Scrotum

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  • (PMID = 20604815.001).
  • [ISSN] 1442-2042
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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18. Akamatsu Y, Murakami K, Watanabe M, Jokura H, Tominaga T: Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations. World Neurosurg; 2010 Jun;73(6):751-4
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  • [Title] Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations.
  • METHODS: We describe a case presenting with malignant peripheral nerve sheath tumor (MPNST) at 8 years after GKRS after incomplete resections.
  • RESULTS: The tumor appeared to be a typical benign schwannoma at the surgery preceding GKRS, and rapidly enlarged after long-term control, causing progressive neurological deterioration.
  • Operative findings showed that the tumor was composed of two different components, and histopathology distinctively demonstrated MPNST and benign schwannoma.
  • CONCLUSIONS: The coexistence of benign and malignant components might indicate that the present MPNST had arisen from the benign schwannoma by transformation in association with GKRS.
  • [MeSH-major] Mixed Tumor, Malignant / etiology. Mixed Tumor, Malignant / pathology. Neoplasms, Radiation-Induced / pathology. Nerve Sheath Neoplasms / etiology. Nerve Sheath Neoplasms / pathology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects
  • [MeSH-minor] Aged. Cell Transformation, Neoplastic / pathology. Cell Transformation, Neoplastic / radiation effects. Female. Humans. Neurosurgical Procedures / methods. Radiation Injuries / diagnosis. Radiation Injuries / pathology. Reoperation / methods. Treatment Failure. Treatment Outcome. Vestibular Nerve / pathology. Vestibular Nerve / radiation effects. Vestibular Nerve / surgery


19. Vaneckova M, Seidl Z, Kemlink D, Zamecnik J, Burgetova A: Cervical meningioma in childhood. A case report. Neuroradiol J; 2008 Jun 03;21(3):383-7
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  • Meningiomas are relatively rare neoplasms in childhood, representing only 1 to 2% of all pediatric intracranial tumors.
  • The distinction between the meningioma and another extramedullary, intradural tumors like schwannoma might pose difficulties.
  • This case report points out that although a very rare tumor in children, it must be taken into account in differential diagnostics.

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  • (PMID = 24256909.001).
  • [ISSN] 1971-4009
  • [Journal-full-title] The neuroradiology journal
  • [ISO-abbreviation] Neuroradiol J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Sandoval-Tress C, Nava-Jiménez G: Poliosis circumscripta associated with neurofibromatosis 1. Australas J Dermatol; 2008 Aug;49(3):167-8
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  • A 38-year-old man presented with axillary freckling, multiple café au lait macules and neurofibromas on the scalp, trunk and extremities.

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  • (PMID = 18638227.001).
  • [ISSN] 1440-0960
  • [Journal-full-title] The Australasian journal of dermatology
  • [ISO-abbreviation] Australas. J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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21. Moon SJ, Lee JK, Seo BR, Kim JH, Kim SH, Lee KH, Lee MC: An intraosseous malignant peripheral nerve sheath tumor of the cervical spine: a case report and review of the literature. Spine (Phila Pa 1976); 2008 Sep 1;33(19):E712-6
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  • [Title] An intraosseous malignant peripheral nerve sheath tumor of the cervical spine: a case report and review of the literature.
  • OBJECTIVES: To report a rare case of intraosseous malignant peripheral nerve sheath tumors (MPNST), and review the pertinent medical literature.
  • SUMMARY OF BACKGROUND DATA: The spinal MPNST that develops from spinal nerve roots and secondary bony erosion is well-known entity.
  • Complete excision of the tumor and posterior stabilization were performed through a posterior approach.
  • The tumor was noted to originate from the posterior element of C7.
  • MPNST should be added to the differential diagnosis of primary bone tumors causing spinal cord compression.
  • [MeSH-major] Cervical Vertebrae / pathology. Nerve Sheath Neoplasms / pathology. Spinal Neoplasms / pathology
  • [MeSH-minor] Adult. Antigens, CD / metabolism. Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Cell Adhesion Molecules / metabolism. Chemotherapy, Adjuvant. Combined Modality Therapy. Disease-Free Survival. Humans. Ki-67 Antigen / metabolism. Magnetic Resonance Imaging. Male. S100 Proteins / metabolism. Spinal Cord Compression / etiology. Spinal Cord Compression / pathology. Vimentin / metabolism

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  • (PMID = 18758353.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Ki-67 Antigen; 0 / S100 Proteins; 0 / Vimentin
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22. Massager N, Nissim O, Delbrouck C, Delpierre I, Devriendt D, Desmedt F, Wikler D, Brotchi J, Levivier M: Irradiation of cochlear structures during vestibular schwannoma radiosurgery and associated hearing outcome. J Neurosurg; 2007 Oct;107(4):733-9
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  • [Title] Irradiation of cochlear structures during vestibular schwannoma radiosurgery and associated hearing outcome.
  • No patient had neurofibromatosis Type 2 disease, and all had a Gardner-Robertson hearing class of I to IV before treatment, and a radiological and audiological follow-up of at least 1-year after GKS.
  • [MeSH-major] Cochlear Nerve / physiology. Hearing Loss / etiology. Neuroma, Acoustic / surgery. Radiosurgery / adverse effects. Vestibular Nerve / surgery

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  • (PMID = 17937216.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Cohen M, Wang MB: Schwannoma of the tongue: two case reports and review of the literature. Eur Arch Otorhinolaryngol; 2009 Nov;266(11):1823-9
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  • [Title] Schwannoma of the tongue: two case reports and review of the literature.
  • The aim of this study was to describe clinicopathologic and radiographic features of two cases of schwannoma involving the oral tongue and to review the literature of this unusual clinical entity.
  • Case reports with review of the pathologic, radiologic and clinical data for two patients with schwannoma of the tongue are reported.
  • Review of the literature of case reports of schwannomas (neurilemmomas) of the tongue from 1955 to 2006 with analysis of the patient's age, gender, presenting symptom(s), tumor size, and surgical approach was undertaken.
  • Transoral excision was performed and pathologic examination confirmed the diagnosis of schwannoma in both the cases.
  • A total of 126 cases of schwannoma of the tongue have been reported in the English literature over the past 51 years.
  • Recurrence after surgical excision has not been reported.
  • Schwannoma of the tongue is a relatively rare tumor of the head and neck.
  • Transoral resection allows for removal of this tumor in a manner that precludes recurrence, avoids causing morbidity of tongue function, and remains the standard approach for the treatment of the vast majority of these tumors.
  • [MeSH-major] Neurilemmoma / pathology. Neurilemmoma / therapy. Tongue Neoplasms / pathology. Tongue Neoplasms / therapy

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  • (PMID = 19130068.001).
  • [ISSN] 1434-4726
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 54
  • [Other-IDs] NLM/ PMC2758150
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24. Tozbikian G, Shen R, Suster S: Signet ring cell gastric schwannoma: report of a new distinctive morphological variant. Ann Diagn Pathol; 2008 Apr;12(2):146-52
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  • [Title] Signet ring cell gastric schwannoma: report of a new distinctive morphological variant.
  • Histologic examination showed large tumor cells infiltrating diffusely through the muscularis propria into the subserosa.
  • Initial diagnostic considerations based on the histology included signet ring cell carcinoma, malignant melanoma, and a myxoid mesenchymal tumor, including gastrointestinal stromal tumor.
  • Electron microscopic examination revealed elongated, complex, and interdigitating cell processes covered by a thin layer of continuous basement membrane material characteristic of peripheral nerve sheath differentiation.
  • The presentation of this tumor was significant in that it was multifocal and infiltrative, mimicking a malignant neoplasm.
  • The extensive myxoid/signet ring cell change represents a heretofore-unreported histologic variant of gastric schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Stomach Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / analysis. Carcinoma, Signet Ring Cell / diagnosis. Cell Nucleus / chemistry. Cell Nucleus / ultrastructure. Cytoplasm / chemistry. Cytoplasm / ultrastructure. Diagnosis, Differential. Female. Humans. S100 Proteins / analysis

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  • (PMID = 18325478.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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25. Ghosh SK, Chakraborty D, Ranjan R, Barman D: Neurofibroma of the external ear - a case report. Indian J Otolaryngol Head Neck Surg; 2008 Sep;60(3):289-90
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  • Neurofibromas are relatively common tumours of the nervous system, but only a few cases involving the external ear have been reported.
  • We are reporting here a case of a 20-year-old female with neurofibroma of the external ear.

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  • (PMID = 23120567.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450637
  • [Keywords] NOTNLM ; External ear / Neurofibroma
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26. Lee EK, Kook SH, Kwag HJ, Park YL, Bae WG: Schwannoma of the breast showing massive exophytic growth: a case report. Breast; 2006 Aug;15(4):562-6
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  • [Title] Schwannoma of the breast showing massive exophytic growth: a case report.
  • Schwannoma is a slow-growing tumor that frequently occurs in the extremities, the trunk and the head region.
  • We present here the case of breast schwannoma in a 41-year-old woman who presented with a palpable mass in her right breast.
  • This is the first report of breast schwannoma that showed massive exophytic growth with invasion of the skin, and it was initially presumed to be a breast cancer on preoperative mammography, ultrasonography and breast MRI examinations.
  • Complete excision of the mass was done and pathology revealed a plexiform schwannoma.
  • [MeSH-major] Breast Neoplasms / pathology. Neurilemmoma / pathology

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  • (PMID = 16844378.001).
  • [ISSN] 0960-9776
  • [Journal-full-title] Breast (Edinburgh, Scotland)
  • [ISO-abbreviation] Breast
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / S100 Proteins
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27. Yang QC, Ji XH, Shen Y, Han F, Zhang XJ, Liu HB: [Gastrointestinal stromal tumor: a clinicopathological study of 74 cases]. Zhonghua Bing Li Xue Za Zhi; 2005 Jan;34(1):6-10
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  • [Title] [Gastrointestinal stromal tumor: a clinicopathological study of 74 cases].
  • OBJECTIVE: To explore a simplified and reproducible approach for the diagnosis and morphologic prognostication of gastrointestinal stromal tumor (GIST).
  • METHODS: Eighty-five cases of gastrointestinal mesenchymal tumors including 74 cases of GIST, 8 esophageal smooth muscle tumor, 1 rectal leiomyosarcoma, 1 Schwannoma, and 1 malignant fibrous histiocytoma were studied by histological evaluation along with an immunohistochemistry panel including vimentin, CD117 (c-kit), CD34, SMA, desmin and S-100.
  • Histologically, the tumors composed of either spindle or oval to round cells arranged in interlacing fascicles forming whorls or cellular clusters, cytoplasm generally abundant and eosinophilic.
  • CONCLUSIONS: GISTs predominantly occur in the middle and old age patients, more common in male, and positive CD117 staining is considered to be the defining marker to differentiate GIST from other mesenchymal tumors of the GI tract.
  • Subclassification of GISTs using Fletcher's scheme appears to be simple, reproducible, and correlates well with the clinical behavior of the tumor.
  • [MeSH-major] Gastrointestinal Stromal Tumors / immunology. Gastrointestinal Stromal Tumors / pathology
  • [MeSH-minor] Actins / metabolism. Adult. Age Factors. Aged. Aged, 80 and over. Antigens, CD34 / metabolism. Disease-Free Survival. Female. Follow-Up Studies. Gastric Mucosa / pathology. Gastric Mucosa / ultrastructure. Humans. Male. Middle Aged. Neoplasm Invasiveness. Proto-Oncogene Proteins c-kit / metabolism. S100 Proteins / metabolism. Sex Factors. Stomach / pathology

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  • (PMID = 15796874.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD34; 0 / S100 Proteins; 0 / smooth muscle actin, rat; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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28. de Silva DJ, Tay E, Rose GE: Schwannomas of the lacrimal gland fossa. Orbit; 2009;28(6):433-5
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  • PURPOSE: Schwannomas are rare benign nerve sheath tumours that account for 1% of orbital tumours and, although sometimes associated with neurofibromatosis, most occur as isolated lesions and arise from branches of the ciliary or trigeminal nerves.
  • METHODS: Two rare cases of Schwannoma arising within the lacrimal gland fossa are presented, these tumours being managed with intact surgical excision.
  • On a presumptive preoperative diagnosis of pleomorphic adenoma, the patient underwent a bone-swinging lateral orbitotomy with intact excision of a moderately-firm, lobulated lesion which proved to be a Schwannoma.
  • CONCLUSIONS: Two very rare cases of Schwannoma arising within the lacrimal gland fossa are presented, the tumours causing complete atrophy of the normal orbital lobe of the lacrimal gland.
  • [MeSH-major] Eye Neoplasms / pathology. Lacrimal Apparatus Diseases / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Glial Fibrillary Acidic Protein / analysis. Humans. S100 Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 19929679.001).
  • [ISSN] 1744-5108
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins
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29. Spurlock G, Bennett E, Chuzhanova N, Thomas N, Jim HP, Side L, Davies S, Haan E, Kerr B, Huson SM, Upadhyaya M: SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. J Med Genet; 2009 Jul;46(7):431-7
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  • OBJECTIVE: Mutations of the SPRED1 gene, one of a family of Sprouty (Spry)/Spred proteins known to "downregulate" mitogen activated protein kinase (MAPK) signalling, have been identified in patients with a mild neurofibromatosis type 1 (NF1) phenotype with pigmentary changes but no neurofibromas (Legius syndrome).To ascertain the frequency of SPRED1 mutations as a cause of this phenotype and to investigate whether other SPRED/SPRY genes may be causal, a panel of unrelated mild NF1 patients were screened for mutations of the SPRED1-3 and the SPRY1-4 genes.
  • [MeSH-minor] Adult. Aged. Base Sequence. Child. Child, Preschool. DNA Mutational Analysis / methods. Female. Humans. Male. Microsatellite Repeats. Middle Aged. Models, Genetic. Molecular Sequence Data. Nerve Tissue Proteins / genetics. Neurofibromin 1 / genetics. Phosphoproteins / genetics. Repressor Proteins / genetics. Syndrome


30. Sharma P, Narwal A, Rana AS, Kumar S: Intraosseous neurofibroma of maxilla in a child. J Indian Soc Pedod Prev Dent; 2009 Jan-Mar;27(1):62-4
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  • Central tumors of neurogenic origin are among the most rare primary jaw tumors in children.
  • Intraosseous neurofibromas of the jaws occur more often as solitary lesions rather than as part of a generalized neurofibromatosis.
  • [MeSH-major] Maxillary Neoplasms / pathology. Neurofibroma / pathology

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  • (PMID = 19414978.001).
  • [ISSN] 0970-4388
  • [Journal-full-title] Journal of the Indian Society of Pedodontics and Preventive Dentistry
  • [ISO-abbreviation] J Indian Soc Pedod Prev Dent
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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31. Black JO, Zhai QJ, Varona OB, Ordonez NG, Luna MA: Primary schwannoma in a cervical lymph node. Head Neck; 2010 Jul;32(7):964-9
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  • [Title] Primary schwannoma in a cervical lymph node.
  • BACKGROUND: Spindle cell neoplasms within lymph nodes are rare and include benign and malignant tumors and primary and metastatic tumors such as palisaded myofibroblastoma, leiomyoma, leiomyosarcoma, reticular cell neoplasms, and vascular sarcomas.
  • Ancillary studies may help distinguish these neoplasms.
  • RESULTS: Gross examination, microscopic examination, immunohistochemistry, and ultrastructural studies were consistent with the diagnosis of schwannoma arising within a lymph node.
  • CONCLUSIONS: We report the first case of intranodal schwannoma arising in a cervical lymph node.
  • The recognition of intranodal schwannoma is important because it is cured with excision, whereas some of the other diagnostic considerations for a spindle cell lesion within a lymph node may require radiation or chemotherapy.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lymph Nodes. Neurilemmoma / pathology

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  • [Copyright] (c) 2009 Wiley Periodicals, Inc.
  • (PMID = 19536856.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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32. Gokalp G, Hakyemez B, Kizilkaya E, Haholu A: Myxoid neurofibromas of the breast: mammographical, sonographical and MRI appearances. Br J Radiol; 2007 Oct;80(958):e234-7
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  • [Title] Myxoid neurofibromas of the breast: mammographical, sonographical and MRI appearances.
  • Neurofibromas arise from elements in the peripheral nervous system and are rarely detected in the breast.
  • Neurofibromas are more common in neurofibromatosis Type 1.
  • In this paper, we present a patient with neurofibromatosis Type 1 with mammographical, sonographical and MRI findings of myxoid neurofibromas in her left breast.
  • [MeSH-major] Breast Neoplasms / diagnosis. Neurofibroma / diagnosis

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  • (PMID = 17959912.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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33. Matsuo T, Onita T, Imasato Y, Yamada J: [A case of retroperitoneal schwannoma extracted by a nerve sparing procedure under microscopic surgery]. Hinyokika Kiyo; 2006 Sep;52(9):707-9
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  • [Title] [A case of retroperitoneal schwannoma extracted by a nerve sparing procedure under microscopic surgery].
  • We report a case in which we extracted retroperitoneal schwannoma by a nerve sparing procedure under microscopic surgery.
  • A left retroperitoneal tumor was found by the abdominal ultrasound sonography.
  • We considered that the tumor arose from the left femoral nerve, and removed it under microscopic surgery.
  • Since it is rare to find the origin nerve of schwannoma before operation, we report our experience.
  • [MeSH-major] Femoral Nerve. Microscopy. Neurilemmoma / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 17040056.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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34. Sen A, Green KM, Khan MI, Saeed SR, Ramsden RT: Cerebrospinal fluid leak rate after the use of BioGlue in translabyrinthine vestibular schwannoma surgery: a prospective study. Otol Neurotol; 2006 Jan;27(1):102-5
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  • [Title] Cerebrospinal fluid leak rate after the use of BioGlue in translabyrinthine vestibular schwannoma surgery: a prospective study.
  • OBJECTIVE: To determine the effectiveness of BioGlue surgical adhesive in dural and middle ear closure after translabyrinthine vestibular schwannoma surgery.
  • INTERVENTIONS: We studied the use of BioGlue and its possible effect on further reducing our department's cerebrospinal fluid leak rate for translabyrinthine vestibular schwannoma surgery.
  • CONCLUSION: Our preliminary prospective study of the use of BioGlue for dural and middle ear closure in translabyrinthine vestibular schwannoma surgery demonstrated poor results.
  • The high cerebrospinal fluid leak rate associated with the unusual presentations and ensuing management difficulties in controlling these leaks lead us to recommend that BioGlue not be used in translabyrinthine vestibular schwannoma surgery.
  • [MeSH-major] Cerebrospinal Fluid Otorrhea / prevention & control. Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Proteins / therapeutic use. Vestibular Nerve. Vestibulocochlear Nerve Diseases / surgery

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  • [CommentIn] Otol Neurotol. 2007 Oct;28(7):992 [17909439.001]
  • [ErratumIn] Otol Neurotol. 2006 Feb;27(2):298
  • (PMID = 16371855.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Bio-glue; 0 / Proteins
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35. Yoshida K, Kawase T, Tomita T, Ogawa K, Kawana H, Yago K, Asanami S: Surgical strategy for tumors located in or extending from the intracranial space to the infratemporal fossa-Advantages of the transcranial approach (zygomatic infratemporal fossa approach) and the indications for a combined transcranial and transcervical approach-. Neurol Med Chir (Tokyo); 2009 Dec;49(12):580-6
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  • [Title] Surgical strategy for tumors located in or extending from the intracranial space to the infratemporal fossa-Advantages of the transcranial approach (zygomatic infratemporal fossa approach) and the indications for a combined transcranial and transcervical approach-.
  • The surgical strategy for tumors located in or extending from the intracranial space to the infratemporal fossa was analyzed in 12 cases with various pathologies.
  • A case of mandibular nerve schwannoma, which extended 1 cm below the external orifice of the foramen ovale, was completely removed via the epidural subtemporal approach without zygomatic osteotomy with partial removal of the middle cranial base.
  • The inferior margin of infratemporal tumor could be accessed via the transcranial route with zygomatic or orbitozygomatic osteotomy without complications including facial nerve injury in nine cases, and the lowest level of the infratemporal tumors was approximately 4.5 cm below the outer surface of the middle cranial base.
  • In five of these 9 cases (2 schwannomas, 1 myxoma, 1 chondrosarcoma, and 1 malignant peripheral nerve sheath tumor), the tumors were localized in the infratemporal fossa, and in the other 4 cases (2 meningiomas, 1 glioblastoma, and 1 ameloblastoma), the tumors extended to both the intracranial space and the infratemporal fossa.
  • In two cases (recurrent jugular schwannoma and mandibular osteosarcoma), a combined transcranial and transcervical approach (mandibular swing approach) was essential, because the resection line of the lower margin was too far from the middle cranial base.
  • These results indicate that the transcranial approach, with or without zygomatic or orbitozygomatic osteotomy (zygomatic infratemporal fossa approach), is safe and effective for removal of some infratemporal tumors, and that a combined transcranial and transcervical approach is useful for removing infratemporal tumors with extensive downward extension.
  • [MeSH-major] Brain Neoplasms / surgery. Craniotomy / methods. Head and Neck Neoplasms / surgery. Neurosurgical Procedures / methods. Skull / surgery
  • [MeSH-minor] Adult. Aged. Cranial Nerve Neoplasms / pathology. Cranial Nerve Neoplasms / radiography. Cranial Nerve Neoplasms / surgery. Cranial Nerves / anatomy & histology. Cranial Nerves / pathology. Cranial Nerves / surgery. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Meningioma / pathology. Meningioma / radiography. Meningioma / surgery. Middle Aged. Neck / anatomy & histology. Neck / surgery. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Orbit / anatomy & histology. Orbit / surgery. Osteotomy / methods. Postoperative Complications / prevention & control. Retrospective Studies. Sarcoma / pathology. Sarcoma / radiography. Sarcoma / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / radiography. Skull Base Neoplasms / surgery. Tomography, X-Ray Computed. Treatment Outcome. Young Adult. Zygoma / anatomy & histology. Zygoma / surgery


36. Biswas D, Marnane CN, Mal RK, Baldwin DL: The presenting features of middle ear facial nerve sheath tumors: a clinical review. Am J Otolaryngol; 2008 Jan-Feb;29(1):58-62
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  • [Title] The presenting features of middle ear facial nerve sheath tumors: a clinical review.
  • Facial nerve sheath tumors are the most common middle ear benign neoplasms.
  • Four facial nerve sheath tumors in the middle ear were diagnosed in our department over a 12-year period, and we described our experience in the management of these tumors.
  • A thorough review of the English literature on middle ear peripheral nerve sheath tumors has been conducted, and the findings of this review are presented and discussed.
  • We have paid particular attention to the presenting features of these tumors with the aim of enhancing diagnostic ability.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Ear, Middle / innervation. Facial Nerve Diseases / diagnosis. Neurilemmoma / diagnosis

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  • [CommentIn] Am J Otolaryngol. 2010 Jan-Feb;31(1):72; author reply 72 [19944908.001]
  • (PMID = 18061834.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 21
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37. Ozturk C, Mirzanli C, Karatoprak O, Tezer M, Aydogan M, Hamzaoglu A: Giant sacral schwannoma: a case report and review of the literature. Acta Orthop Belg; 2009 Oct;75(5):705-10
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  • [Title] Giant sacral schwannoma: a case report and review of the literature.
  • They frequently grow to considerable size before detection; hence, the term giant sacral schwannoma.
  • Sacral schwannomas arise from the sacral nerve roots.
  • This case report documents the management of a 48-year-old male with a giant sacral schwannoma.
  • We performed a two-stage surgery with intralesional tumour resection.
  • The patient is now free of any complaint, complications and there is no recurrence two years after resection of the schwannoma.
  • Intralesional excision of a sacral schwannoma is a less invasive procedure than total or partial sacrectomy.
  • Using a combined anterior and posterior approach, satisfactory tumour excision and stabilization can be achieved, while avoiding the high morbidity related with total sacrectomy.
  • [MeSH-major] Bone Neoplasms / diagnosis. Neurilemmoma / diagnosis. Sacrum

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  • (PMID = 19999888.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Belgium
  • [Number-of-references] 23
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38. Brown KD, Hansen MR: Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cells. Otol Neurotol; 2008 Jan;29(1):79-85
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  • [Title] Lipid raft localization of ErbB2 in vestibular schwannoma and schwann cells.
  • HYPOTHESIS: ErbB2 resides in lipid rafts (regions of receptor regulation) in vestibular schwannoma (VS) cells.
  • METHODS: Protein extracts from VS or rat sciatic nerve (proximal or distal to a crush injury) were isolated into lipid raft and nonraft fractions and immunoblotted for erbB2, phosphorylated erbB2, and merlin (for sciatic nerve).
  • [MeSH-major] Glycoproteins / metabolism. Membrane Microdomains / pathology. Neuroma, Acoustic / pathology. Peripheral Nervous System Neoplasms / pathology. Schwann Cells / pathology
  • [MeSH-minor] Actins / genetics. Actins / metabolism. Animals. Antimetabolites. Blotting, Western. Bromodeoxyuridine. Female. Humans. Immunohistochemistry. Male. Rats. Rats, Sprague-Dawley. Receptor, ErbB-2. Sciatic Nerve / pathology. Tumor Cells, Cultured

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  • (PMID = 18199961.001).
  • [ISSN] 1531-7129
  • [Journal-full-title] Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
  • [ISO-abbreviation] Otol. Neurotol.
  • [Language] eng
  • [Grant] United States / NIDCD NIH HHS / DC / K08 DC006211
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antimetabolites; 0 / Erbb2 protein, rat; 0 / Glycoproteins; EC 2.7.10.1 / Receptor, ErbB-2; G34N38R2N1 / Bromodeoxyuridine
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39. Amin MU, Shafique M: Isolated malignant peripheral nerve sheath tumor of retroperitoneum. J Coll Physicians Surg Pak; 2007 Apr;17(4):226-7
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  • [Title] Isolated malignant peripheral nerve sheath tumor of retroperitoneum.
  • A case of an isolated Malignant Peripheral Nerve Sheath Tumor (MPNST) of the retroperitoneum without neurofibromatosis is presented.
  • The tumor was located deep in the retroperitoneum with metastasis to the ribs.

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  • (PMID = 17462183.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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40. Rahman M, Cook DS, Ellis G, O'keefe PA: Malignant peripheral nerve sheath tumor of the heart. Asian Cardiovasc Thorac Ann; 2006 Oct;14(5):425-7
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  • [Title] Malignant peripheral nerve sheath tumor of the heart.
  • A 32-year-old man presented with dyspnea, chest pain, palpitations and ankle edema and was found to have a tumor involving the heart.
  • This was diagnosed as malignant peripheral nerve sheath tumor, a rare sarcoma of the heart.
  • [MeSH-major] Heart Neoplasms / diagnosis. Nerve Sheath Neoplasms / diagnosis

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  • (PMID = 17005894.001).
  • [ISSN] 1816-5370
  • [Journal-full-title] Asian cardiovascular & thoracic annals
  • [ISO-abbreviation] Asian Cardiovasc Thorac Ann
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 8
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41. Moon SE, Cho YJ, Kwon OS: Subungual schwannoma: a rare location. Dermatol Surg; 2005 May;31(5):592-4
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  • [Title] Subungual schwannoma: a rare location.
  • BACKGROUND: Schwannoma is a benign tumor of neural tissue and usually develops in deeper soft tissue.
  • In fact, it has not been previously reported.
  • OBJECTIVE: To present a case of subungual schwannoma.
  • METHOD: A 49-year-old man had a subungual tumor on his right thumb of 8 years duration.
  • The tumor was excised using a transungual approach.
  • CONCLUSION: We describe a case of schwannoma that developed in the subungual area of a thumb.
  • Although schwannoma rarely develops in this area, it should be considered in the differential diagnosis of subungual tumor.
  • [MeSH-major] Bone Neoplasms / diagnosis. Nails, Malformed / etiology. Neurilemmoma / diagnosis

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  • (PMID = 15962750.001).
  • [ISSN] 1076-0512
  • [Journal-full-title] Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • [ISO-abbreviation] Dermatol Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Spinner RJ, Scheithauer BW, Perry A, Amrami KK, Emnett R, Gutmann DH: Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. J Neurosurg; 2007 Aug;107(2):435-9
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  • [Title] Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report.
  • The authors report on a patient without neurofibromatosis Type 1 or 2 (NF1 or NF2) and without evidence of schwannomatosis, who was found to have an unusual combination of nerve sheath tumors-a large cellular schwannoma and multifascicular involvement of a plexiform neurofibroma arising from the same site within the radial nerve and posterior cord of the infraclavicular brachial plexus.
  • This case broadens the spectrum of combined pathological features of nerve sheath tumors.
  • The latter finding supports the suggestion that these were two different clonal neoplasms, and is consistent with a collision tumor pattern.
  • [MeSH-major] Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Neurofibroma, Plexiform / pathology. Peripheral Nervous System Neoplasms / pathology. Radial Nerve


43. Carter JE, Laurini JA: Isolated intestinal neurofibromatous proliferations in the absence of associated systemic syndromes. World J Gastroenterol; 2008 Nov 14;14(42):6569-71
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  • In this setting, the lesions may manifest as focal scattered neurofibromas or as an extensive diffuse neural hyperplasia designated ganglioneuromatosis.
  • Occasionally, such lesions may be the initial sign of NF1 in patients without any other clinical manifestations of the disease.
  • We present the case of a 52 year-old female with abdominal pain and alternating bowel habits.

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  • (PMID = 19030214.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2773348
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44. Tanaka K, Hara I, Yamaguchi K, Takeda M, Takenaka A, Fujisawa M: Laparoscopic resection of a lower posterior mediastinal tumor: feasibility of using a transdiaphragmatic approach. Urology; 2007 Dec;70(6):1215-8
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  • [Title] Laparoscopic resection of a lower posterior mediastinal tumor: feasibility of using a transdiaphragmatic approach.
  • INTRODUCTION: Either video-assisted thoracoscopic surgery (VATS) or a thoracotomy is usually performed for a resection of posterior mediastinal tumors.
  • We used a laparoscopic approach to resect a lower posterior mediastinal tumor mimicking a right adrenal tumor that had been identified by a preoperative computed tomography (CT) scan, because this approach is less invasive than VATS or a thoracotomy, regarding the potential to cause damage to the respiratory organs.
  • A laparoscopic transdiaphragmatic excision of this lower posterior mediastinal tumor was attempted and accomplished safely.
  • The tumor was completely resected without damaging the pleura.
  • The pathological findings of the specimen demonstrated schwannoma.
  • This surgical modality can thus be performed on selected lower posterior mediastinal tumors.
  • [MeSH-major] Laparoscopy. Mediastinal Neoplasms / surgery. Neurilemmoma / surgery

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  • (PMID = 18158051.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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45. Diallo BK, Franco-Vidal V, Vasili D, Négrevergne M, Darrouzet P, Diouf R, Darrouzet V: [The neurotologic evaluation of vestibular schwannomas. Results of audiological and vestibular testing in 100 consecutive cases]. Rev Laryngol Otol Rhinol (Bord); 2006;127(4):203-9
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  • [Transliterated title] L' evaluation neurotologique audio-vestibulaire des schwannomes vestibulaires. A propos de 100 cas.
  • OBJECTIVES: To determine the results and sensitivity of a comprehensive audiological and vestibular work-up in patients presenting with vestibular schwannoma (VS).
  • The tumour size was classified according to Koos classification and hearing was assessed according to the five-stage classification from the Tokyo consensus.
  • Responses could not be analyzed in 28% of patients.
  • This patient had a small intrameatal tumour and actually complained of contralateral symptoms.

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  • (PMID = 17315783.001).
  • [ISSN] 0035-1334
  • [Journal-full-title] Revue de laryngologie - otologie - rhinologie
  • [ISO-abbreviation] Rev Laryngol Otol Rhinol (Bord)
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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46. Bacciu A, Falcioni M, Pasanisi E, Di Lella F, Lauda L, Flanagan S, Sanna M: Intracranial facial nerve grafting after removal of vestibular schwannoma. Am J Otolaryngol; 2009 Mar-Apr;30(2):83-8
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  • [Title] Intracranial facial nerve grafting after removal of vestibular schwannoma.
  • OBJECTIVE: The objectives of this study were to evaluate outcomes from facial nerve (FN) cable grafting in patients who experienced FN transection during vestibular schwannoma removal and to compare the FN outcomes of patients who underwent FN grafting by using fibrin glue with those of patients who underwent FN grafting by using microsuture.
  • RESULTS: At 12 months, a House-Brackmann grade III was achieved in 75% of those who underwent cable nerve graft interposition by using microsuture and in 76% of those who underwent cable nerve graft interposition by using fibrin glue.
  • However, the technique of FN repair by means of fibrin glue is technically simple, less time-consuming, and imparts less trauma on the nerve than does the traditional suture method.
  • [MeSH-major] Facial Nerve Injuries / surgery. Fibrin Tissue Adhesive / therapeutic use. Neuroma, Acoustic / surgery. Postoperative Complications. Suture Techniques. Tissue Adhesives / therapeutic use

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  • (PMID = 19239948.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fibrin Tissue Adhesive; 0 / Tissue Adhesives
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47. Yamamoto M, Yamauchi T, Okano K, Takahashi M, Watabe S, Yamamoto Y: Tranilast, an anti-allergic drug, down-regulates the growth of cultured neurofibroma cells derived from neurofibromatosis type 1. Tohoku J Exp Med; 2009 Mar;217(3):193-201
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  • Neurofibromas are benign tumors that comprise primarily of Schwann cells and fibroblasts.
  • Mast cells have been found scattered in the tumor tissue, and their role in promoting the proliferation of neurofibroma has been suggested.
  • In order to prove this hypothesis, we investigated the effectiveness of tranilast in inhibiting the tumor growth using a new cell culture system obtained from patients with neurofibromas.
  • These results suggest that tranilast retards tumor proliferation through not only suppression of cell growth factor, but also the inhibition of a chemical mediator released from mast cells.
  • Thus, tranilast can be a potent therapeutic agent to inhibit the growth of neurofibromas.

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  • (PMID = 19282654.001).
  • [ISSN] 1349-3329
  • [Journal-full-title] The Tohoku journal of experimental medicine
  • [ISO-abbreviation] Tohoku J. Exp. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Anti-Allergic Agents; 0 / Stem Cell Factor; 0 / Transforming Growth Factor beta; 0 / ortho-Aminobenzoates; EC 3.4.21.59 / Tryptases; HVF50SMY6E / tranilast
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48. Sadatomo T, Yuki K, Migita K, Hidaka T, Kurisu K: [Accessory nerve schwannoma of the intracisternal type: a case report]. No Shinkei Geka; 2010 Sep;38(9):831-7
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  • [Title] [Accessory nerve schwannoma of the intracisternal type: a case report].
  • Accessory nerve schwannomas are extremely rare and they are classified into three types according to their locations; intrajugular, intracisternal and spinal canal type.
  • We report a case of intracisternal schwannoma that arose from the spinal accessory nerve roots and we describe it's clinical characteristics.
  • Total removal of the tumor was performed by the left lateral suboccipital approach and the histological diagnosis was schwannoma.
  • [MeSH-major] Accessory Nerve. Cranial Nerve Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • (PMID = 20864772.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
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49. Bayindir T, Kalcioglu MT, Kizilay A, Karadag N, Akarcay M: Ancient schwannoma of the parotid gland: a case report and review of the literature. J Craniomaxillofac Surg; 2006 Jan;34(1):38-42
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  • [Title] Ancient schwannoma of the parotid gland: a case report and review of the literature.
  • Schwannomas are encapsulated benign tumours arising from nerve sheath cells, of which ancient schwannoma is one of five variants.
  • In the parotid gland, this tumour is very rare.
  • In this report, a 41-year-old female patient with an ancient schwannoma of the parotid gland is presented and the data of this patient compared with other (comparable) cases described in the literature.
  • [MeSH-major] Neurilemmoma / pathology. Parotid Neoplasms / pathology

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  • (PMID = 16343919.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / S100 Proteins
  • [Number-of-references] 30
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50. Dane B, Dane C, Basaran S, Erginbas M, Cetin A: Vaginal Schwannoma in a case with uterine myoma. Ann Diagn Pathol; 2010 Apr;14(2):137-9
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  • [Title] Vaginal Schwannoma in a case with uterine myoma.
  • Only 1% of gynecological neoplasms are vaginal, and mesenchymal tumors constitute only 2% of vaginal neoplasms.
  • Schwannomas arise from the peripheral nerve sheath.
  • We report a case of vaginal schwannoma associated with uterine myoma.
  • Surgical excision of the mass from vaginal aspect was also undertaken, and the histology demonstrated schwannoma.
  • The tumor cells were vimentin (+), desmin (-), smooth muscle alpha-actin (-), HMB-45 (-), MART-1 (-) and S-100 (+).
  • The differential diagnosis of a mass in the vagina includes also schwannomas.
  • Immunocytochemical labeling of the tumor cells is essential.
  • [MeSH-major] Leiomyoma / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology. Uterine Neoplasms / pathology. Vaginal Neoplasms / pathology


51. Uzun L, Ugur MB, Ozdemir H: Cervical sympathetic chain schwannoma mimicking a carotid body tumor: a case report. Tumori; 2005 Jan-Feb;91(1):84-6
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  • [Title] Cervical sympathetic chain schwannoma mimicking a carotid body tumor: a case report.
  • Carotid body tumor (CBT), the most common tumor of the carotid bifurcation, presents as a pulsatile mass.
  • A case of CSC schwannoma masquerading as CBT in a 25-year-old woman is presented and discussed here.
  • [MeSH-major] Adrenergic Fibers. Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / diagnosis
  • [MeSH-minor] Adult. Carotid Body Tumor / diagnosis. Diagnosis, Differential. Female. Humans. Neck

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  • (PMID = 15850012.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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52. Yang I, Paik E, Huh NG, Parsa AT, Ames CP: Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case report. J Med Case Rep; 2009;3:88
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  • [Title] Giant thoracic schwannoma presenting with abrupt onset of abdominal pain: a case report.
  • INTRODUCTION: Giant intradural extramedullary schwannomas of the thoracic spine are not common.
  • Schwannomas, that is, tumors derived from neoplastic Schwann cells, and neurofibromas represent the most common intradural extramedullary spinal lesions.
  • We report the case of a patient with a giant thoracic schwannoma presenting unusually with acute abdominal pain and with delayed neurological impairment.
  • After extensive work-up including an exploratory laparotomy for appendectomy, magnetic resonance imaging scans of the lumbar and thoracic spine revealed a giant intradural extramedullary thoracic schwannoma within the spinal canal posterior to the T9, T10, and T11 vertebral bodies.
  • Magnetic resonance imaging signal prolongation was noted in the spinal cord both rostral and caudal to the schwannoma.
  • After sacrificing the T10 root, the tumor was removed en bloc.
  • This referred pain may represent a mechanism by which a giant thoracic schwannoma may present as acute abdominal pain.
  • Acute, intense abdominal pain with delayed neurologic deficit is a rare presentation of a thoracic schwannoma but should be considered as a possible cause of abdominal pain presenting without clear etiology.

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  • (PMID = 19946504.001).
  • [ISSN] 1752-1947
  • [Journal-full-title] Journal of medical case reports
  • [ISO-abbreviation] J Med Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2783087
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53. Alpízar-Aguirre A, Chávez-Miguel C, Zárate-Kalfópulos B, Rosales-Olivares LM, del Carmen Baena-Ocampo L, Reyes-Sánchez A: [Primary intradural extramedullary tumors treated at the National Institute of Rehabilitation (Mexico)]. Cir Cir; 2009 Mar-Apr;77(2):107-10
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  • [Title] [Primary intradural extramedullary tumors treated at the National Institute of Rehabilitation (Mexico)].
  • [Transliterated title] Tumores intradurales extramedulares primarios tratados en el Instituto Nacional de Rehabilitación.
  • BACKGROUND: Spine tumors are uncommon injuries affecting a low percentage of the population; however, these tumors can cause significant morbidity and may be related to mortality.
  • They represent 15% of craniospinal tumors.
  • The objective of this study is to determine the frequency of intradural extramedullary spine tumors treated in our Service and to report the definitive histopathological diagnosis.
  • METHODS: This was a retrospective study in a series of patients treated surgically with a diagnosis of intradural extramedullary tumor in the Spine Service of the National Rehabilitation Institute (Mexico) from 1996 to 2006.
  • The following variables were evaluated: gender, age, tumor localization, symptomatology and type of tumor.
  • Histopathological diagnosis reported 12 cases of meningioma, 12 cases of schwannoma and 3 cases of neurofibroma.
  • Different from other series, schwannomas and meningiomas were the most frequent tumors in our study.
  • [MeSH-major] Spinal Cord Neoplasms

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  • (PMID = 19534860.001).
  • [ISSN] 0009-7411
  • [Journal-full-title] Cirugía y cirujanos
  • [ISO-abbreviation] Cir Cir
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
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54. Shimose S, Sugita T, Kubo T, Matsuo T, Nobuto H, Tanaka K, Arihiro K, Ochi M: Major-nerve schwannomas versus intramuscular schwannomas. Acta Radiol; 2007 Jul;48(6):672-7
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  • [Title] Major-nerve schwannomas versus intramuscular schwannomas.
  • BACKGROUND: A schwannoma is a benign peripheral nerve tumor.
  • Predicting the involvement of a nerve on symptoms or magnetic resonance (MR) findings is crucial to the diagnostic process.
  • PURPOSE: To compare symptoms, MR findings, and histological findings between major-nerve schwannomas and intramuscular schwannomas.
  • MATERIAL AND METHODS: Thirty-four patients with 36 palpable schwannomas (29 major-nerve schwannomas and seven intramuscular schwannomas) surgically excised and proven histologically were retrospectively reviewed.
  • RESULTS: Frequencies of the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin indicate the presence of a nerve, and were significantly higher in major-nerve schwannomas than in intramuscular schwannomas.
  • In tumor morphological patterns (target sign, inhomogeneous and homogeneous pattern), there were no significant differences between major-nerve schwannomas and intramuscular schwannomas.
  • All major-nerve schwannomas and five of the intramuscular schwannomas produced some characteristic symptoms and/or MR findings, but two intramuscular schwannomas did not have any characteristic symptoms and findings.
  • CONCLUSION: In major-nerve schwannomas, the Tinel-like sign, split-fat sign, entering and exiting nerve, and low-signal margin are commonly observed and useful for diagnosis.
  • [MeSH-major] Muscle Neoplasms / diagnosis. Neurilemmoma / diagnosis. Peripheral Nervous System Neoplasms / diagnosis

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  • (PMID = 17611877.001).
  • [ISSN] 0284-1851
  • [Journal-full-title] Acta radiologica (Stockholm, Sweden : 1987)
  • [ISO-abbreviation] Acta Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Sweden
  • [Chemical-registry-number] 0 / Contrast Media; K2I13DR72L / Gadolinium DTPA
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55. Kesser BW, Hashisaki GT, Fletcher K, Eppard H, Holt JR: An in vitro model system to study gene therapy in the human inner ear. Gene Ther; 2007 Aug;14(15):1121-31
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  • We generated organotypic cultures from 26 human sensory epithelia excised at the time of labyrinthectomy for intractable Meniere's disease or vestibular schwannoma.

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  • (PMID = 17568767.001).
  • [ISSN] 0969-7128
  • [Journal-full-title] Gene therapy
  • [ISO-abbreviation] Gene Ther.
  • [Language] ENG
  • [Grant] United States / NIDCD NIH HHS / DC / DC005439; United States / NIDCD NIH HHS / DC / DC005439-05; United States / NIDCD NIH HHS / DC / R01 DC005439; United States / NIDCD NIH HHS / DC / R56 DC005439; United States / NIDCD NIH HHS / DC / R01 DC005439-05
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / KCNQ Potassium Channels; 0 / KCNQ4 protein, human; 147336-22-9 / Green Fluorescent Proteins
  • [Other-IDs] NLM/ NIHMS86848; NLM/ PMC2742230
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56. Doufexi A, Mina M, Ioannidou E: Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review. J Periodontol; 2005 Jan;76(1):3-10
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  • The most prevalent types of gingival overgrowth in children are drug-induced gingival overgrowth, hereditary gingival fibromatosis (HGF), and neurofibromatosis I (von Recklinghausen disease).
  • Genetic heterogeneity seems to play an important role in the development of the disease.
  • This autosomal dominant disease usually appears at the time of eruption of permanent dentition.
  • Neurofibromatosis I is an autosomal dominant disease more common in mentally handicapped individuals.
  • Gingival overgrowth is caused by the formation of plexiform neurofibromas in the connective tissue of the gingiva.
  • Plexiform neurofibromas are pathognomonic of the disease and consist of hypertrophic nerves arranged as lobules in the connective tissue.
  • Complications of the disease are multiple and severe due to neurofibromas and their occasional malignant transformation.

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  • (PMID = 15830631.001).
  • [ISSN] 0022-3492
  • [Journal-full-title] Journal of periodontology
  • [ISO-abbreviation] J. Periodontol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anticonvulsants; 0 / Immunosuppressive Agents; 83HN0GTJ6D / Cyclosporine
  • [Number-of-references] 90
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57. Gonzalez LF, Lekovic GP, Eschbacher J, Coons S, Spetzler RF: A true malignant schwannoma of the eighth cranial nerve: case report. Neurosurgery; 2007 Aug;61(2):E421-2; discussion E422
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  • [Title] A true malignant schwannoma of the eighth cranial nerve: case report.
  • OBJECTIVE: The clinical presentation, pathology, treatment, and outcome of a 43-year-old woman with a malignant peripheral nerve sheath tumor arising from a benign schwannoma of the eighth cranial nerve are presented.
  • CLINICAL PRESENTATION: Initially, the tumor was debulked.
  • After finding malignant areas within the benign tumor, it was considered to be a malignant transformation of a previously benign tumor.
  • Postoperatively, the tumor bed was radiated for palliation.
  • CONCLUSION: Despite surgery, radiation, and chemotherapy, the patient died rapidly as a result of disseminated metastatic disease.
  • [MeSH-major] Cranial Nerve Neoplasms / pathology. Neuroma, Acoustic / secondary. Vestibulocochlear Nerve / pathology
  • [MeSH-minor] Adult. Dura Mater / pathology. Fatal Outcome. Female. Humans. Magnetic Resonance Imaging. Meningeal Neoplasms / secondary

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  • (PMID = 17762727.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Inokuchi T, Takiuchi H, Moriwaki Y, Ka T, Takahashi S, Tsutsumi Z, Shima H, Hirota S, Yamamoto T: Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings. Magn Reson Imaging; 2006 Dec;24(10):1389-93
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  • [Title] Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings.
  • Our computed tomographic scans showed bilateral and well-circumscribed low-density suprarenal masses, while MRI revealed the tumors to be heterogeneous with low intensity on T1-weighted images and high intensity on T2-weighted images.
  • A laparoscopic adrenalectomy was performed under the suspicion of a malignant tumor, such as a malignant fibrous histiocytoma.
  • Pathologic findings indicated a retroperitoneal ancient schwannoma of two histologic types: Antoni A and Antoni B.
  • We considered that elucidation of the characteristic features of a schwannoma would provide helpful preoperative information for diagnosis.
  • [MeSH-major] Magnetic Resonance Imaging. Neurilemmoma / pathology. Retroperitoneal Neoplasms / pathology. Tomography, X-Ray Computed
  • [MeSH-minor] Abdomen / ultrasonography. Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / radiography. Adrenal Gland Neoplasms / ultrasonography. Adult. Diagnosis, Differential. Female. Humans

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  • (PMID = 17145411.001).
  • [ISSN] 0730-725X
  • [Journal-full-title] Magnetic resonance imaging
  • [ISO-abbreviation] Magn Reson Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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59. Hoekstra HJ, von Meyenfeldt MF: [A swelling in the knee cavity, not caused by a Baker's cyst but by a nerve sheath tumour]. Ned Tijdschr Geneeskd; 2005 May 21;149(21):1189; author reply 1190
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  • [Title] [A swelling in the knee cavity, not caused by a Baker's cyst but by a nerve sheath tumour].
  • [Transliterated title] Een zwelling in de knieholte, niet veroorzaakt door een Baker-cyste, maar door een zenuwschedetumor.
  • [MeSH-major] Knee. Nerve Sheath Neoplasms / diagnosis. Neurilemmoma / diagnosis

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  • [CommentOn] Ned Tijdschr Geneeskd. 2005 Feb 5;149(6):312-6 [15730041.001]
  • (PMID = 15940925.001).
  • [ISSN] 0028-2162
  • [Journal-full-title] Nederlands tijdschrift voor geneeskunde
  • [ISO-abbreviation] Ned Tijdschr Geneeskd
  • [Language] dut
  • [Publication-type] Comment; Letter
  • [Publication-country] Netherlands
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60. Zhang HY, Yang GH, Chen HJ, Wei B, Ke Q, Guo H, Ye L, Bu H, Yang K, Zhang YH: Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J (Engl); 2005 Sep 5;118(17):1451-61
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  • [Title] Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma.
  • BACKGROUND: Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • The description of the course of the tumors differs somewhat, but it is generally considered as a benign lesion.
  • We investigated the clinicopathologic features, immunophenotypes, and ultrastructural features of 13 patients with nonpsammomatous melanotic schwannoma (NPMS).
  • METHODS: Tumor specimens of each patient were sectioned and stained with hematoxylin-eosin, Fontana-Masson, Prussian blue, and periodic acid-Schiff (PAS).
  • The tumor sites included the spinal nerve root (5 patients), cranial nerve (1), greater omentum (1), subcutaneous tissue (3), mesentery (1), bone (1) and mediastinum (1).
  • One patient (9.1%) with a primary tumor in the greater omentum developed another primary tumor of the same type in the subcutaneous tissue of the abdominal wall after the first operation.
  • Local recurrence of the tumor was seen in 2 patients (18.2%).
  • Grossly, all tumors were well-circumscribed and the gross findings were suggestive of melanin-containing tumors.
  • The tumor was composed of spindled and epithelioid cells with abundant intracytoplasmic melanin pigments.
  • Ultrastructurally, numerous elongated tumor-cell processes, duplicated basement membrane and melanosomes were observed in all developmental stages.
  • CONCLUSIONS: Histologically, melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of schwann cells.
  • Distinguishing between this tumor and malignant melanoma is of paramount importance in planning of management.
  • Immunohistochemically, combined use of laminin and collagen IV is valuable in distinguishing melanotic schwannoma from malignant melanoma.
  • Further studies including cytogenetic or molecular biology are still required to better delineate melanotic schwannoma from malignant melanoma.
  • [MeSH-major] Neurilemmoma / pathology. Soft Tissue Neoplasms / pathology


61. Jung TY, Jung S, Kim IY, Kang SS: Intracisternal schwannoma of the spinal accessory nerve: a case report. Skull Base; 2006 Aug;16(3):175-9
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  • [Title] Intracisternal schwannoma of the spinal accessory nerve: a case report.
  • We report the details of a patient with an intracisternal schwannoma that developed from the spinal accessory nerve.
  • The tumor arose from one rootlet of the right accessory nerve and histological examination confirmed the diagnosis of a schwannoma.
  • Removal of the schwannoma did not result in a significant neurological deficit.

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  • [Cites] Acta Neurochir (Wien). 1975;31(3-4):201-21 [1081330.001]
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  • (PMID = 17268591.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1586173
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62. Piedra MP, Scheithauer BW, Driscoll CL, Link MJ: Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report. Neurosurgery; 2006 Jul;59(1):E206; discussion E206
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary melanocytic tumor of the cerebellopontine angle mimicking a vestibular schwannoma: case report.
  • OBJECTIVE: The majority of tumors of the cerebellopontine angle (CPA) are benign.
  • We report the case of a primary malignant melanoma of the CPA that mimicked a vestibular schwannoma (acoustic neuroma).
  • A neurological work-up revealed a large tumor in the left CPA radiographically diagnosed as a vestibular schwannoma.
  • INTERVENTION: A translabyrinthine approach revealed a pigmented, vascular neoplasm encasing vessels and cranial nerves of the left CPA.
  • The tumor was subtotally resected, and a histopathological diagnosis of melanoma was made.
  • The patient had no history of cutaneous melanoma and no other site of disease was ever discovered.
  • CONCLUSION: This case most likely represents primary melanoma of the central nervous system that mimicked a vestibular schwannoma.
  • [MeSH-major] Cerebellar Neoplasms / diagnosis. Cerebellopontine Angle. Melanocytes / pathology. Melanoma / diagnosis. Neuroma, Acoustic / diagnosis


63. Holl N, Kremer S, Wolfram-Gabel R, Dietemann JL: [The spinal canal: from imaging anatomy to diagnosis]. J Radiol; 2010 Sep;91(9 Pt 2):950-68
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  • [Transliterated title] Espaces rachidiens intracanalaires: de l'anatomie radiologique au diagnostic étiologique.
  • The subarachnoid space is home to the CSF, spinal cord and nerve rootlets.
  • Subarachnoid processes include primary tumors, leptomeningeal metastases, arachnoiditis and hemorrhage.
  • Nerve sheath tumors and meningiomas are the most frequent intradural extramedullary tumors.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging. Image Enhancement. Image Processing, Computer-Assisted. Magnetic Resonance Imaging. Spinal Canal / pathology. Spinal Diseases / diagnosis. Spinal Neoplasms / diagnosis

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  • (PMID = 20814388.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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64. Upadhyaya M, Kluwe L, Spurlock G, Monem B, Majounie E, Mantripragada K, Ruggieri M, Chuzhanova N, Evans DG, Ferner R, Thomas N, Guha A, Mautner V: Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). Hum Mutat; 2008 Jan;29(1):74-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).
  • About 10% of neurofibromatosis type 1 (NF1) patients develop malignant peripheral nerve sheath tumors (MPNSTs) and represent considerable patient morbidity and mortality.
  • Elucidation of the genetic mechanisms by which inherited and acquired NF1 disease gene variants lead to MPNST development is important.
  • Somatic NF1 mutations were identified in tumor DNA from 31 out of 34 MPNSTs, of which 28 were large genomic deletions.
  • The high prevalence (>90%) of such deletions in MPNST contrast with the =or<20% found in benign neurofibromas and is indicative of the involvement of different mutational mechanisms in these tumors.
  • Coinactivation of the TP53 gene by deletion, or by point mutation along with NF1 gene inactivation, is known to exacerbate disease symptoms in NF1, therefore TP53 gene inactivation was screened.
  • DNA from 20 tumors showed evidence for loss of heterozygosity (LOH) across the TP53 region in 11 samples, with novel TP53 point mutations in four tumors.
  • [MeSH-major] Germ-Line Mutation. Mutation. Nerve Sheath Neoplasms / genetics. Neurofibromin 1 / genetics. Peripheral Nervous System Neoplasms / genetics
  • [MeSH-minor] Adult. DNA Mutational Analysis. DNA, Neoplasm / metabolism. Humans. Loss of Heterozygosity. Lymphocytes / metabolism. Sequence Deletion. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 / metabolism

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17960768.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Neurofibromin 1; 0 / Tumor Suppressor Protein p53
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65. Park CK, Kim DC, Park SH, Kim JE, Paek SH, Kim DG, Jung HW: Microhemorrhage, a possible mechanism for cyst formation in vestibular schwannomas. J Neurosurg; 2006 Oct;105(4):576-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECT: Cystic vestibular schwannoma (VS) is a unique subgroup of VSs characterized by unpredictable expansion of the cyst component.
  • Preoperative magnetic resonance images and histological characteristics of the tumor in patients with cystic VSs were evaluated and compared with those in the group with solid VSs.

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  • (PMID = 17044561.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 9011-92-1 / Hemosiderin
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66. Lee MJ, Su YN, You HL, Chiou SC, Lin LC, Yang CC, Lee WC, Hwu WL, Hsieh FJ, Stephenson DA, Yu CL: Identification of forty-five novel and twenty-three known NF1 mutations in Chinese patients with neurofibromatosis type 1. Hum Mutat; 2006 Aug;27(8):832
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neurofibromatosis type 1 (NF1), characterized by skin neurofibromas and an excess of café-au-lait spots, is due to mutations in the neurofibromin (NF1) gene.
  • Identifying the genetic defect in individuals with the disease represents a significant challenge because the gene is extremely large with a high incidence of sporadic mutations across the entire gene ranging from single nucleotide substitutes to large deletions.

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  • (PMID = 16835897.001).
  • [ISSN] 1098-1004
  • [Journal-full-title] Human mutation
  • [ISO-abbreviation] Hum. Mutat.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / RNA Splice Sites
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67. Chirieac LR, Dekmezian RH, Ayala AG: Characterization of the myxoid variant of hibernoma. Ann Diagn Pathol; 2006 Apr;10(2):104-6
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  • Hibernomas are rare benign neoplasms composed of brown adipose tissue.
  • In this report, we present and characterize the spectrum of morphological features of the myxoid variant of hibernoma by describing the case of a 45-year-old white man who was referred to our hospital for treatment of an ovoid mass in the posterior segment of the right deltoid region.
  • Histopathologic examination of the resected specimen revealed a multilobulated, tan-yellow, variegated tumor with a rubbery consistency that was separated by thick fibrous septa with interspersed collections of foamy histiocytes.
  • The mass was initially diagnosed as schwannoma with degenerative changes, but workup revealed a myxoid variant of hibernoma.
  • This report highlights recent advances that may help confirm the diagnosis and explain the differential diagnosis of this rare tumor.
  • This is one of only a few cases of a myxoid variant of hibernoma reported in the literature.
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Immunohistochemistry. Male

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  • (PMID = 16546046.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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68. Mohammed S, Kovacs K, Munoz D, Cusimano MD: A short illustrated review of sellar region schwannomas. Acta Neurochir (Wien); 2010 May;152(5):885-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: In this short illustrated review, we present the case of a frontal lobe schwannoma without cranial nerve or sellar attachment and a sellar schwannoma which mimicked a pituitary adenoma.
  • [MeSH-major] Brain Neoplasms / pathology. Frontal Lobe / pathology. Neurilemmoma / pathology. Sella Turcica / pathology. Skull Base Neoplasms / pathology

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  • (PMID = 20130958.001).
  • [ISSN] 0942-0940
  • [Journal-full-title] Acta neurochirurgica
  • [ISO-abbreviation] Acta Neurochir (Wien)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Austria
  • [Number-of-references] 21
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69. Khorgami Z, Nasiri S, Rezakhanlu F, Sodagari N: Malignant schwannoma of anterior abdominal wall: report of a case. J Clin Med Res; 2009 Oct;1(4):233-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant schwannoma of anterior abdominal wall: report of a case.
  • Malignant schwannoma of the anterior abdominal wall nerves is extremely rare.
  • Malignant peripheral nerve sheath tumors (MPNST) represent approximately 10% of all soft tissue sarcomas and it is found in 4% of patients with neurofibromatosis 1.
  • We present a case of malignant schwannoma in a 28-year-old female patient with neurofibromatosis 1.
  • The tumor location was in the abdominal wall in explorative laparatomy and malignant schwannoma was diagnosed in pathologic assessment.
  • The tumor recurred in 3 months and computed tomography showed two masses in the right side of abdominopelvic cavity.
  • Thereafter, second complete surgical resection was performed and pathologic finding was the same.
  • In spite of administering chemotherapy after second surgery,the tumor recurred and magnetic resonance imaging finding showed a huge heterogeneously enhancing mass with adhesion to the inner side of the abdominal wall.
  • Tumor location and rapid recurrence was unique in our patient.
  • KEYWORDS: Malignant peripheral nerve sheath tumor; Malignant schwannoma; Abdominal wall.

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  • (PMID = 22461875.001).
  • [ISSN] 1918-3003
  • [Journal-full-title] Journal of clinical medicine research
  • [ISO-abbreviation] J Clin Med Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC3299187
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70. Gabhane SK, Kotwal MN, Bobhate SK: Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases. Indian J Pathol Microbiol; 2009 Jan-Mar;52(1):29-33
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  • [Title] Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases.
  • By convention, soft tissue tumors include the peripheral nerve sheath tumor (PNST) although they arise from neuroectoderm.
  • Malignant transformation in benign tumors, especially neurofibroma, is an acknowledged phenomenon.This article describes clinico-pathological features of 126 PNSTs with their morphological variants and those associated with neurofibromatosis 1 (NF1) encountered in a single center over a 6-year period.
  • Histological variants including plexiform schwannomas and diffuse, plexiform and pigmented forms of neurofibromas, though rare, were observed.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19136775.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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71. Oztanir N, Emmez H, Aytar MH, Dogan M, Kaymaz M, Baykaner MK: Malignant intracerebral giant nerve sheath tumor in a 14-month-old girl with neurofibromatosis type 1: a case report. Childs Nerv Syst; 2009 Feb;25(2):253-6
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  • [Title] Malignant intracerebral giant nerve sheath tumor in a 14-month-old girl with neurofibromatosis type 1: a case report.
  • INTRODUCTION: Malignant intracerebral nerve sheath tumor (MINST) is extremely rare and the origin is still unclear.
  • The authors present the clinical, radiological, and pathological features of a malignant intracerebral giant nerve sheath tumor.
  • CASE REPORT: A giant tumor in the right frontotemporoparietal lobes causing a midline shift was detected in a 14-month-old girl who presented with developmental delay, vomiting, and lethargy.
  • DISCUSSION: There are only six cases of malignant intracerebral nerve sheath tumor in the literature.
  • The presented case is the youngest and the occurrence of MINST in a 14-month-old girl may support the hypothesis of multipotent mesenchymal stem cell origin; however, the tumors which arise from multipotent mesenchymal stem cells may be seen in later stages of life.
  • CONCLUSION: MINSTs are extremely rare tumors with unknown origin.
  • The location, the degree, and the size of the tumor and the general condition of the patient are prognostic factors in MINSTs, like in other malignant tumors.
  • [MeSH-major] Brain Neoplasms / diagnosis. Nerve Sheath Neoplasms / diagnosis. Neurofibromatosis 1 / diagnosis

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  • [CommentIn] Childs Nerv Syst. 2009 May;25(5):517; author reply 519 [19271223.001]
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  • (PMID = 18972118.001).
  • [ISSN] 1433-0350
  • [Journal-full-title] Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
  • [ISO-abbreviation] Childs Nerv Syst
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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72. Dharia A, Karmody CS, Rebeiz EE: Schwannoma of the nasal cavity. Ear Nose Throat J; 2007 Apr;86(4):230-1, 243
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  • [Title] Schwannoma of the nasal cavity.
  • Schwannomas are benign peripheral nerve sheath tumors that occur throughout the body.
  • We present a new case of a schwannoma of the nasal cavity.
  • [MeSH-major] Nasal Cavity / surgery. Neurilemmoma / surgery. Nose Neoplasms / surgery
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Female. Humans. Nasal Obstruction / etiology. Nasal Obstruction / surgery. Nasal Septum / pathology. Nasal Septum / surgery. Otoscopy. S100 Proteins / analysis. Tomography, X-Ray Computed

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  • (PMID = 17500396.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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73. Komoribayashi N, Arai H, Kojo T, Obonai C, Wakabayashi J, Ogawa A: [Subfrontal schwannoma: case report]. No Shinkei Geka; 2005 Jun;33(6):601-5
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  • [Title] [Subfrontal schwannoma: case report].
  • Schwannoma are benign, slowly growing nerve sheath tumors.
  • They can arise from any peripheral nerve containing Schwann cells including distal portions of cranial nerves.
  • We report a case of subfrontal schwannoma in a 38-year-old woman who presented with seizures in February 2003.
  • The left carotid angiography revealed that the tumor was supplied from the anterior ethomoidal artery, but no remarkable tumor stain was detected.
  • Bifrontal craniotomy with total excision of the tumor revealed a tumor in the left subfrontal lesion.
  • The tumor was attached to the falx, the left frontal lobe, and the skull base, but those structures were not invaded.
  • Unfortunately, we could not detect the left olfactory nerve.
  • Subsequent histological examination proved that this tumor was schwannoma.
  • For this reason they have not been diagnosed preoperatively.
  • Further cases of subfrontal schwannoma are necessary to solve the enigma of the origin of this tumor.
  • [MeSH-major] Brain Neoplasms / surgery. Neurilemmoma / surgery

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  • (PMID = 15952309.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 28
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74. Nannapaneni R, Sinar EJ: Intraosseous schwannoma of the cervical spine. Br J Neurosurg; 2005 Jun;19(3):244-7
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  • [Title] Intraosseous schwannoma of the cervical spine.
  • The authors report a rare case of a cervical intraosseous schwannoma, which was diagnosed following an incidental history of trauma.
  • This is the first case of an intraosseous schwannoma of the cervical vertebra that was diagnosed using magnetic resonance imaging.
  • [MeSH-major] Cervical Vertebrae / pathology. Neurilemmoma / pathology. Spinal Neoplasms / pathology

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  • (PMID = 16455526.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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75. Saito DM, Glastonbury CM, El-Sayed IH, Eisele DW: Parapharyngeal space schwannomas: preoperative imaging determination of the nerve of origin. Arch Otolaryngol Head Neck Surg; 2007 Jul;133(7):662-7
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  • [Title] Parapharyngeal space schwannomas: preoperative imaging determination of the nerve of origin.
  • OBJECTIVES: To determine if preoperative radiographic cross-sectional images can predict the nerve of origin of a parapharyngeal schwannoma and, specifically, whether it originates from the vagus nerve or the cervical sympathetic chain.
  • The nerve of origin was identified based on operative findings and postoperative physical examinations.
  • A CAQ (Certificate of Added Qualification)-certified neuroradiologist reviewed the imaging studies, blinded to the surgically determined nerve of origin.
  • For each case, it was predicted whether the tumor arose from the vagus nerve or sympathetic chain based on the location of the schwannoma with reference to the carotid sheath vessels.
  • RESULTS: At the time of operation, it was determined that 5 patients (42%) had schwannomas from the cervical sympathetic chain and 7 patients (58%) had schwannomas of the cervical vagus nerve.
  • By imaging, the nerve of origin was successfully determined in 4 of 5 cases of sympathetic chain schwannoma (80%) and in 7 of 7 cases of vagal nerve schwannoma (100%).
  • Vagal nerve schwannomas were found to separate the carotid arteries from the internal jugular vein.
  • A vagal nerve schwannoma may also displace the sheath vessels posteriorly, without splaying them.
  • CONCLUSIONS: Carotid and jugular vessel displacement, as determined by cross-sectional imaging, can predict the likely nerve of origin of a parapharyngeal space schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Pharyngeal Neoplasms / pathology. Preoperative Care
  • [MeSH-minor] Adolescent. Adult. Contrast Media / administration & dosage. Female. Ganglia, Sympathetic / pathology. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed. Vagus Nerve / pathology

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  • (PMID = 17638778.001).
  • [ISSN] 0886-4470
  • [Journal-full-title] Archives of otolaryngology--head & neck surgery
  • [ISO-abbreviation] Arch. Otolaryngol. Head Neck Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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76. Baser ME, Mautner VF, Parry DM, Evans DG: Methodological issues in longitudinal studies: vestibular schwannoma growth rates in neurofibromatosis 2. J Med Genet; 2005 Dec;42(12):903-6
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  • [Title] Methodological issues in longitudinal studies: vestibular schwannoma growth rates in neurofibromatosis 2.
  • Four longitudinal studies of vestibular schwannoma (VS) growth rates in neurofibromatosis 2 (NF2) have yielded very different results on the relationship of VS growth rates to age.


77. Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E: Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature. J Cutan Pathol; 2010 Sep;37(9):997-1001
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  • [Title] Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
  • Neuroblastoma-like schwannoma was first described by Goldblum et al. in 1994, and very few cases have since been reported.
  • It is a benign sporadic neoplasm with no reported association with neurofibromatosis, and is characterized histologically by small round lesional cells surrounding collagenous cores forming rosette-like structures.
  • The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma.
  • [MeSH-major] Neurilemmoma / pathology. Neuroblastoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / metabolism. Female. Humans. Treatment Outcome

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  • (PMID = 19922484.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Sucandy I, Sharma D, Dalencourt G, Bertsch DJ: Gallbladder neurofibroma presenting as chronic epigastric pain - Case report and review of the literature. N Am J Med Sci; 2010 Oct;2(10):496-8
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  • CONTEXT: Benign nonepithelial neoplasms of the gallbladder are unusual.
  • The majority of gallbladder neurofibromas are found incidentally in the gallbladder specimens following cholecystectomy.
  • Open conversion was necessitated because of the presence of a gallbladder mass preventing safe anatomic dissection.
  • CONCLUSIONS: Benign neoplasms such as gallbladder neurofibroma should be included in the differential diagnosis for chronic epigastric pain symptom in a young otherwise healthy patient with neurofibromatosis.

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  • (PMID = 22558554.001).
  • [ISSN] 1947-2714
  • [Journal-full-title] North American journal of medical sciences
  • [ISO-abbreviation] N Am J Med Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3339114
  • [Keywords] NOTNLM ; Neurofibroma / benign tumors / gallbladder
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79. Wohlsein P, Cichowski S, Baumgärtner W: Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour. J Comp Pathol; 2005 May;132(4):340-5
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  • [Title] Primary endocardial malignant spindle-cell sarcoma in the right atrium of a dog resembling a malignant peripheral nerve sheath tumour.
  • An unusual malignant spindle-cell sarcoma in the right atrium of a 7-year-old male hunting terrier is described.
  • The neoplasm arose from the endocardium, protruded into the lumen of the right atrium, was covered with endothelium, and showed local invasive growth into the atrial wall.
  • The tumour was composed of interlacing bundles of spindle cells, sometimes arranged in whorls resembling the Antoni type A pattern.
  • Immunohistochemistry revealed an intense labelling of tumour cells for vimentin, and a partial labelling for neuron-specific enolase, S100 protein, and Melan-A.
  • The morphology of the tumour indicated a primary malignant peripheral nerve sheath tumour, resembling a neoplasm described in rats.
  • [MeSH-major] Dog Diseases / pathology. Endocardium / pathology. Heart Neoplasms / veterinary. Nerve Sheath Neoplasms / pathology. Sarcoma / veterinary
  • [MeSH-minor] Animals. Biomarkers, Tumor / metabolism. Diagnosis, Differential. Dogs. Euthanasia, Animal. Heart Atria / metabolism. Heart Atria / pathology. Immunohistochemistry / veterinary. Male

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  • (PMID = 15893992.001).
  • [ISSN] 0021-9975
  • [Journal-full-title] Journal of comparative pathology
  • [ISO-abbreviation] J. Comp. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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80. Bibas BJ, Madeira M, Gavina R, Hoehl-Carneiro L, Sardinha S: A rare case of synchronous malignant thoracic tumors. J Bras Pneumol; 2009 Feb;35(2):186-9
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  • [Title] A rare case of synchronous malignant thoracic tumors.
  • Malignant neurogenic mediastinal tumors in adults are uncommon and extremely aggressive.
  • We report the case of a 61-year-old male patient with the simultaneous occurrence of malignant mediastinal schwannoma and bronchioloalveolar carcinoma.
  • Although bronchioloalveolar carcinoma is present in 4-7% of the resected synchronous thoracic tumors, this association has never been reported in the literature.
  • However, it is a common finding in patients presenting apparently inflammatory infiltrates and ground-glass opacities, as in the case presented here.
  • [MeSH-major] Adenocarcinoma, Bronchiolo-Alveolar / pathology. Lung Neoplasms / pathology. Mediastinal Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19287923.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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81. Kilmurray LG, Ortega L, Martínez A, Sanz Esponera J: Neurofibroma with psammoma bodies. Histol Histopathol; 2006 09;21(9):965-8
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  • Neurofibromas are benign tumours of the nerve sheath.
  • A 41-year old male with radicular pain had a tumour involving the posterior chest wall.
  • Although these bodies are very frequent in some neoplasias, to our knowledge they have not been described in neurofibromas to date.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Neurofibroma / pathology
  • [MeSH-minor] Adult. Calcium / metabolism. Humans. Immunohistochemistry. Male. Peripheral Nervous System Neoplasms / diagnosis. Peripheral Nervous System Neoplasms / pathology

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  • (PMID = 16763946.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] SY7Q814VUP / Calcium
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82. Fang WS, Emerson LL, Hunt JP, Salzman KL: An unusual sinonasal tumor: soft tissue perineurioma. AJNR Am J Neuroradiol; 2009 Feb;30(2):437-9
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  • [Title] An unusual sinonasal tumor: soft tissue perineurioma.
  • Soft tissue perineuriomas are an unusual type of peripheral nerve sheath tumors distinct from schwannomas and neurofibromas, with interesting histologic findings.
  • They are not well characterized on radiographic examination.
  • We report this case of a patient with sinonasal perineurioma to help define the imaging and pathologic features of this rare head and neck tumor.
  • [MeSH-major] Nerve Sheath Neoplasms / pathology. Paranasal Sinus Neoplasms / pathology. Paranasal Sinuses / pathology
  • [MeSH-minor] Biopsy. Chromosomes, Human, Pair 22. Endoscopy. Female. Humans. In Situ Hybridization, Fluorescence. Middle Aged. Soft Tissue Neoplasms / pathology. Soft Tissue Neoplasms / radiography. Soft Tissue Neoplasms / surgery. Tomography, X-Ray Computed

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  • (PMID = 19182108.001).
  • [ISSN] 1936-959X
  • [Journal-full-title] AJNR. American journal of neuroradiology
  • [ISO-abbreviation] AJNR Am J Neuroradiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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83. Grover M: Facial nerve sheath tumors. Am J Otolaryngol; 2010 Jan-Feb;31(1):72; author reply 72
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  • [Title] Facial nerve sheath tumors.
  • [MeSH-major] Cranial Nerve Neoplasms / diagnosis. Facial Nerve Diseases / diagnosis. Neurilemmoma / diagnosis

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  • [CommentOn] Am J Otolaryngol. 2008 Jan-Feb;29(1):58-62 [18061834.001]
  • (PMID = 19944908.001).
  • [ISSN] 1532-818X
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Comment; Letter
  • [Publication-country] United States
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84. Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M: Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals. Genes Chromosomes Cancer; 2008 Mar;47(3):238-46
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  • [Title] Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals.
  • Telomerase activity (TA) and the expression of its enzymatic subunits, which have been demonstrated in many tumors, remain poorly investigated in tumors associated with neurofibromatosis type 1 (NF1).
  • In this study, we analysed the association of TA and the expression of telomerase RNA (TR) and telomerase reverse transcriptase (TERT) in 23 malignant peripheral nerve sheath tumors (MPNST) (17 high grade and 6 low grade tumors), 11 plexiform neurofibromas (PNF) and 6 dermal neurofibromas (DNF).
  • TA was detected in 14 out of 17 (82%) high grade MPNST, whereas all 6 low grade MPNST and 17 benign tumors were telomerase negative.
  • The TERT transcripts were detected in all high grade MPNST, 50% of the low grade MPNST, and 4 benign tumors.
  • Thus, while TERT expression was similar in both low grade MPNST and PNF (P = 0.115), it was significantly higher in high grade MPNST when compared to either low grade MPNST (P = 0.042), PNF (P = 0.001) or DNF tumors (P = 0.010).
  • [MeSH-major] Nerve Sheath Neoplasms / diagnosis. Neurofibromatosis 1 / complications. RNA / analysis. Severity of Illness Index. Telomerase / analysis. Telomerase / metabolism

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 18069666.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / telomerase RNA; 63231-63-0 / RNA; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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85. Al Sanosi A, Fagan PA, Biggs ND: Conservative management of acoustic neuroma. Skull Base; 2006 May;16(2):95-100
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  • AIM OF STUDY: To identify those patients with vestibular schwannoma (acoustic neuroma) in whom treatment becomes necessary.
  • RESULT: A total of 205 patients with small tumors were followed for a mean of 40.8 months.
  • In 136 patients (66.3%) the tumor did not grow.
  • Eight of 197 patients (4%) had rapid growth and 6 patients (3%) had radiological evidence of tumor regression.
  • Five of these showed rapid growth, four developed ataxia in whom tumor growth was slow, three had ataxia without tumor growth, two patients developed brainstem compression, and one patient elected to proceed to surgery, although there were no tumor growth or symptoms.
  • CONCLUSION: Few patients with small tumors will come to surgery in the short term.
  • Perhaps the majority of patients with such small tumors will not need surgery.
  • Long-term follow-up studies of 20 years or more are required to be come more confident about the natural history of these tumors.

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  • (PMID = 17077873.001).
  • [ISSN] 1531-5010
  • [Journal-full-title] Skull base : official journal of North American Skull Base Society ... [et al.]
  • [ISO-abbreviation] Skull Base
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC1502035
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86. Oiso N, Iba Y, Kawara S, Kawada A: Halo phenomenon in neurofibromas and generalized vitiligo in a patient with neurofibromatosis type 1. Clin Exp Dermatol; 2007 Mar;32(2):207-8
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  • [Title] Halo phenomenon in neurofibromas and generalized vitiligo in a patient with neurofibromatosis type 1.
  • [MeSH-major] Neurofibromatosis 1 / pathology. Skin Neoplasms / pathology. Vitiligo / pathology


87. Petrela E, Hodge CJ, Hahn SS, Chung CT, Mejico LJ: Stereotactic radiosurgery in two cases of presumed fourth cranial nerve schwannoma. J Neuroophthalmol; 2009 Mar;29(1):54-7
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  • [Title] Stereotactic radiosurgery in two cases of presumed fourth cranial nerve schwannoma.
  • A 47-year-old woman and a 45-year-old man with gradually progressive fourth cranial nerve palsy underwent stereotactic radiosurgery for presumed fourth cranial nerve schwannomas with the gamma knife at a marginal tumor dose of 14 and 13 Gy, respectively.
  • MRI showed shrinkage of the tumors.
  • These patients represent the second and third reported cases of presumed fourth cranial nerve schwannoma treated with radiosurgery and the first cases with substantial follow-up information.
  • [MeSH-major] Cranial Nerve Neoplasms / surgery. Neurilemmoma / surgery. Radiosurgery. Trochlear Nerve Diseases / surgery

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  • (PMID = 19458578.001).
  • [ISSN] 1536-5166
  • [Journal-full-title] Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
  • [ISO-abbreviation] J Neuroophthalmol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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88. Rousseau MA, Pascal-Mousselard H, Lazennec JY, Saillant G: The mini-invasive anterior extra peritoneal approach to the pelvis. Eur J Surg Oncol; 2005 Oct;31(8):924-6
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  • We present here an original mini-invasive anterior retroperitoneal approach the pelvic retroperitoneum, which was successful in a 26-year-old woman who had a benign schwannoma of the left sacral plexus.
  • [MeSH-major] Neurilemmoma / surgery. Peritoneum / surgery. Retroperitoneal Neoplasms / surgery
  • [MeSH-minor] Abdominal Muscles / surgery. Adipose Tissue / surgery. Adult. Female. Humans. Lumbosacral Plexus / surgery. Minimally Invasive Surgical Procedures / methods. Peripheral Nervous System Neoplasms / surgery. Psoas Muscles / surgery

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  • (PMID = 16009529.001).
  • [ISSN] 0748-7983
  • [Journal-full-title] European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • [ISO-abbreviation] Eur J Surg Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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89. Li F, Munchhof AM, White HA, Mead LE, Krier TR, Fenoglio A, Chen S, Wu X, Cai S, Yang FC, Ingram DA: Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells. Hum Mol Genet; 2006 Jun 1;15(11):1921-30
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  • Neurofibromatosis type I (NF1) is a genetic disorder caused by mutations in the NF1 tumor suppressor gene.
  • Further, NF1 patients develop vascular neurofibromas where tumor vessels are invested in a dense pericyte sheath.
  • Thus, these studies identify neurofibromin as a novel regulator of Ras activity in VSMCs and provide a framework for understanding cardiovascular disease in NF1 patients and a mechanism by which Ras signals are attenuated for maintaining VSMC homeostasis in blood vessel walls.

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  • (PMID = 16644864.001).
  • [ISSN] 0964-6906
  • [Journal-full-title] Human molecular genetics
  • [ISO-abbreviation] Hum. Mol. Genet.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1K08 CA 096579-01; United States / NCI NIH HHS / CA / P30 CA 82709; United States / NINDS NIH HHS / NS / P50 NS 052606
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Neurofibromin 1; 0 / Platelet-Derived Growth Factor; 0 / Proto-Oncogene Proteins c-sis; 0 / platelet-derived growth factor BB; EC 3.6.5.2 / ras Proteins
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90. Ismail NJ, Shehu BB, Lasseini A, Hassan I, Shilong DJ, Obande JO, Sahabi SM: Solitary giant neurofibroma of the scalp with calvarial defect in a child. J Surg Tech Case Rep; 2010 Jan;2(1):24-6
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  • De novo solitary types are less common and rarely erode the skull, unlike the intracranial counterpart.
  • Skull erosion has been reported in adults with longstanding plexiform neurofibromas.
  • We report a giant neurofibroma on the scalp of a five-year-old boy, managed in our center.

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  • (PMID = 22091326.001).
  • [ISSN] 0976-2825
  • [Journal-full-title] Journal of surgical technique and case report
  • [ISO-abbreviation] J Surg Tech Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3214485
  • [Keywords] NOTNLM ; Calvarial defect / scalp neurofibroma / solitary giant
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91. Ohene-Yeboah M, Adjei E, Stalsberg H: A giant guteal schwannoma with extension into the pelvis: a case report. West Afr J Med; 2009 May;28(3):185-8
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  • [Title] A giant guteal schwannoma with extension into the pelvis: a case report.
  • BACKGROUND: Schwannomas are uncommon slow growing tumours arising from the nerve sheath or Schwann cell.
  • OBJECTIVE: To report a case and the surgical removal of a giant complex schwannoma and to highlight the value of extensive investigations including a preoperative histologic diagnosis in the successful surgical management of uncommon large benign tumours.
  • METHODS: A 39-year-old man presented with a 15-year history of a large mass in the right gluteal region.
  • The CT scan showed a very large, well defined lobulated tumour with cystic spaces and enhancing nodules.
  • The tumour extended through the ischiadic foramen into the pelvis and posteriorly into the thigh muscles.
  • A Doppler scan of the pelvic vessels revealed that the right common and internal iliac arteries were both compressed but not occluded.
  • An incisional biopsy was reported as a Schwannoma with xanthomatous changes and an immuno histochemistry profile of S-100+, Ki-67+ (less than 1% of the cells).
  • It is essential that a preoperative histological diagnosis is made to establish that the tumor is truly benign.
  • [MeSH-major] Buttocks / radiography. Neurilemmoma / pathology. Pelvis / radiography. Retroperitoneal Neoplasms / pathology

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  • (PMID = 20306737.001).
  • [ISSN] 0189-160X
  • [Journal-full-title] West African journal of medicine
  • [ISO-abbreviation] West Afr J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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92. Wu JM, Sheth S, Ali SZ: Cytopathologic analysis of paraspinal masses: a study of 59 cases with clinicoradiologic correlation. Diagn Cytopathol; 2005 Sep;33(3):157-61
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  • Patients were 14-83 yr of age (mean 54.7) with a M:F ratio of 1.36:1.
  • Of these, 8 (21%) revealed nonneoplastic lesions and 31 (79%) yielded neoplasms: 2 (6%) benign and 29 (94%) malignant.
  • Of the malignant cases, 22 (76%) were metastatic tumors from various sites, while 7 (24%) were cancers from local spread, which included non-Hodgkin's lymphoma (NHL, 5) and myeloma (2).
  • Benign neoplasms were nerve sheath tumors.
  • Metastatic tumors consisted of adenocarcinoma, 9; squamous-cell carcinoma, 3; renal-cell carcinoma, 1; and non-small-cell carcinoma/not otherwise specified (NOS), 9.
  • In instances of radiologic and cytopathologic discrepancy (4 cases, 12%), diagnoses made by FNA reversed the initial radiologic impression of neoplasm to infection, and vice versa.
  • The sensitivity and specificity of a PSM FNA are 88% and 75% respectively.
  • [MeSH-major] Biopsy, Fine-Needle. Spinal Neoplasms / diagnosis

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  • [Copyright] Copyright (c) 2005 Wiley-Liss, Inc.
  • (PMID = 16078252.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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93. Ozdemir N, Bezircioğlu H, Akar O: Giant erosive spinal schwannomas: surgical management. Br J Neurosurg; 2010 Oct;24(5):526-31
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  • Therapeutic radical tumour excision without neurologic deterioration is possible in the management.
  • Prognosis is good after total tumour removal.
  • Our experience and other published literature suggest that giant erosive spinal schwannoma has significant features such as local invasive nature together with vertebral body erosion and large size but benign histology, long duration for clinical presentation, common preoperative misdiagnosis and good prognosis after total excision.
  • [MeSH-major] Neurilemmoma / surgery. Spinal Neoplasms / surgery

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  • (PMID = 20515264.001).
  • [ISSN] 1360-046X
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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94. Relles D, Baek J, Witkiewicz A, Yeo CJ: Periampullary and duodenal neoplasms in neurofibromatosis type 1: two cases and an updated 20-year review of the literature yielding 76 cases. J Gastrointest Surg; 2010 Jun;14(6):1052-61
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  • [Title] Periampullary and duodenal neoplasms in neurofibromatosis type 1: two cases and an updated 20-year review of the literature yielding 76 cases.
  • BACKGROUND: Patients with neurofibromatosis type 1 (NF1) are at increased risk to develop tumors throughout the gastrointestinal tract, including neuromas, gastrointestinal stromal tumors (GIST), and periampullary somatostatin-rich carcinoids.
  • Mean tumor size was 3.8 cm (range 0.9-27 cm).
  • Tumor location was the duodenum (60%), ampulla (31%), pancreas (5%), or bile duct/gallbladder (4%).
  • Tumor type was reported as somatostatinoma (40%), GIST (34%), adenocarcinoma (8%), carcinoid (6%), neurofibroma (5%), schwannoma (4%), or gangliocytic paraganglioma (3%).
  • Mean follow-up was 31 months postresection (range 0-99 months): 75% of patients were alive with no evidence of disease.
  • CONCLUSIONS: These results underscore the importance of a thorough evaluation for tumors in NF1 patients with gastrointestinal symptoms, as well as subsequent surgical management when findings suggest a tumor in the periampullary region, as resection remains the mainstay of treatment.
  • [MeSH-major] Ampulla of Vater. Common Bile Duct Neoplasms / diagnosis. Duodenal Neoplasms / diagnosis. Neurofibromatosis 1 / complications

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  • (PMID = 20300877.001).
  • [ISSN] 1873-4626
  • [Journal-full-title] Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
  • [ISO-abbreviation] J. Gastrointest. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 76
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95. Lee SM, Goldblum J, Kim KM: Microcystic/reticular schwannoma in the colon. Pathology; 2009;41(6):595-6
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  • [Title] Microcystic/reticular schwannoma in the colon.
  • [MeSH-major] Colonic Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adult. Biomarkers, Tumor / analysis. Carcinoid Tumor / diagnosis. Diagnosis, Differential. Female. Gastrointestinal Stromal Tumors / diagnosis. Humans. Nerve Sheath Neoplasms / diagnosis. Perivascular Epithelioid Cell Neoplasms / diagnosis. S100 Proteins / analysis

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  • (PMID = 19900114.001).
  • [ISSN] 1465-3931
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / S100 Proteins
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96. Tortorelli AP, Papa V, Rosa F, Pacelli F, Doglietto GB: Image of the month--retroperitoneal schwannoma. Arch Surg; 2006 Dec;141(12):1259-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Image of the month--retroperitoneal schwannoma.
  • [MeSH-major] Neurilemmoma / radiography. Retroperitoneal Neoplasms / radiography. Tomography, X-Ray Computed

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  • (PMID = 17178970.001).
  • [ISSN] 0004-0010
  • [Journal-full-title] Archives of surgery (Chicago, Ill. : 1960)
  • [ISO-abbreviation] Arch Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Kim DH, Murovic JA, Tiel RL, Moes G, Kline DG: A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center. J Neurosurg; 2005 Feb;102(2):256-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A series of 146 peripheral non-neural sheath nerve tumors: 30-year experience at Louisiana State University Health Sciences Center.
  • OBJECT: This is a retrospective review of 146 surgically treated benign and malignant peripheral non-neural sheath tumors (PNNSTs).
  • Tumor classifications with patient numbers, locations of benign PNNSTs, and surgical techniques and adjunctive treatments are presented.
  • The results of a literature review regarding tumor frequencies are presented.
  • The benign tumors included 33 ganglion cysts, 16 cases of localized hypertrophic neuropathy, 12 lipomas, 12 tumors of vascular origin, and 11 desmoid tumors.
  • There were four each of lipofibrohamartomas, myositis ossificans, osteochondromas, and ganglioneuromas; two each of meningiomas, cystic hygromas, myoblastoma or granular cell tumors, triton tumors, and lymphangiomas; and one epidermoid cyst.
  • There were two melanomas metastatic to nerve and one tumor each that had metastasized from the bladder, rectum, skin, head and neck, and thyroid, and from a primary Ewing sarcoma.
  • There was a single lymphoma that had metastasized to the radial nerve and one chordoma and one osteosarcoma, each of which had metastasized to the brachial plexus.
  • Benign tumors were relatively equally distributed in the brachial plexus region and upper and lower extremities, with the exception of the pelvic plexus, which had only one tumor.
  • [MeSH-major] Brachial Plexus Neuropathies / surgery. Hypogastric Plexus / surgery. Peripheral Nervous System Neoplasms / surgery

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  • (PMID = 15739553.001).
  • [ISSN] 0022-3085
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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98. Ramanjam V, Adnams C, Ndondo A, Fieggen G, Fieggen K, Wilmshurst J: Clinical phenotype of South African children with neurofibromatosis 1. J Child Neurol; 2006 Jan;21(1):63-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fewer patients had neurofibromas (4%), but more patients had plexiform neurofibromas of the head and neck (16%).
  • [MeSH-minor] Brain / pathology. Cafe-au-Lait Spots / epidemiology. Child. Child Behavior Disorders / epidemiology. Child, Preschool. Cognition Disorders / epidemiology. Comorbidity. Female. Head and Neck Neoplasms / epidemiology. Humans. Infant. Infant, Newborn. Leg / diagnostic imaging. Magnetic Resonance Imaging. Male. Neurofibroma, Plexiform / epidemiology. Optic Nerve Glioma / epidemiology. Prevalence. Radiography. Retrospective Studies. South Africa / epidemiology

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  • (PMID = 16551456.001).
  • [ISSN] 0883-0738
  • [Journal-full-title] Journal of child neurology
  • [ISO-abbreviation] J. Child Neurol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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99. Chettiar K, Sriskandan N, Thiagaraj S, Desai AU, Ross K, Howlett DC: The use of ultrasound-guided wire localisation in orthopaedics. J Bone Joint Surg Br; 2009 May;91(5):659-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The use of ultrasound-guided wire localisation of lesions is not well described in the orthopaedic literature.
  • We describe a case of an impalpable schwannoma of the femoral nerve and another of sacroiliitis with an associated pelvic abscess.
  • [MeSH-major] Biopsy, Needle / methods. Femoral Nerve / ultrasonography. Neurilemmoma / ultrasonography. Staphylococcal Infections / ultrasonography. Ultrasonography, Interventional / methods
  • [MeSH-minor] Adolescent. Arthritis, Infectious / ultrasonography. Female. Humans. Male. Middle Aged. Orthopedic Procedures / methods. Pelvis / ultrasonography. Peripheral Nervous System Neoplasms / ultrasonography. Sacroiliac Joint / ultrasonography

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  • (PMID = 19407303.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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100. Chen XD, Qian M, Tu WF, Liao QL, Zhou BC: [Cardiac schwannoma: report of a case]. Zhonghua Bing Li Xue Za Zhi; 2006 Mar;35(3):186-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cardiac schwannoma: report of a case].
  • [MeSH-major] Cochlear Nerve / pathology. Cranial Nerve Neoplasms / pathology. Heart Neoplasms / pathology. Neurilemmoma / pathology
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Neoplasms, Multiple Primary / metabolism. Neoplasms, Multiple Primary / pathology. S100 Proteins / metabolism. Vestibulocochlear Nerve Diseases / metabolism. Vestibulocochlear Nerve Diseases / pathology. Vimentin / metabolism

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  • (PMID = 16630514.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / S100 Proteins; 0 / Vimentin
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