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1. Yang SC, Chen LH, Fu TS, Lai PL, Niu CC, Chen WJ: Surgical treatment for giant cell tumor of the thoracolumbar spine. Chang Gung Med J; 2006 Jan-Feb;29(1):71-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment for giant cell tumor of the thoracolumbar spine.
  • BACKGROUND: Giant cell tumor (GCT) of the bone has historically been regarded as an extremely unpredictable bone tumor.
  • The anatomical characteristics of spinal GCT still present challenges to surgeons.
  • Controversy remains regarding the proper treatment of patients with grade III tumors.
  • METHODS: Eleven patients with grade III GCT of the thoracolumbar spine were treated between 1992 and 2002 at a medical center by the authors.
  • RESULTS: Five patients had tumor recurrence.
  • One patient, who received radiotherapy, had local relapse with malignant transformation and finally died due to disease-related complications.
  • One patient had a recurrent tumor with multiple metastases throughout the lung.
  • CONCLUSION: Wide excision of GCT of the thoracolumbar spine is difficult and there is a risk of neurological deficit and spinal instability.
  • Early detection of recurrent GCT during intensive follow-up can allow for treatment using en bloc excision which has achieved favorable prognoses.
  • [MeSH-major] Giant Cell Tumors / surgery. Lumbar Vertebrae. Spinal Neoplasms / surgery. Thoracic Vertebrae

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  • (PMID = 16642729.001).
  • [ISSN] 2072-0939
  • [Journal-full-title] Chang Gung medical journal
  • [ISO-abbreviation] Chang Gung Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China (Republic : 1949- )
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2. Martin C, McCarthy EF: Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature. Iowa Orthop J; 2010;30:69-75
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  • [Title] Giant cell tumor of the sacrum and spine: series of 23 cases and a review of the literature.
  • Although there have been a few large case series of giant cell tumor (GCT) in the spine and sacrum, the treatment of these lesions remains controversial.
  • We are reporting 23 additional cases of giant cell tumor in the spine and sacrum gathered from our institution and the personal consultation files of the senior author.
  • Most patients presented with pain or neurologic deficit at the site of tumor involvement, and symptoms were usually present for many months prior to diagnosis.
  • Six of the sacral GCT patients were treated with pre-operative arterial embolization and intralesional surgical resection, and two developed a recurrence.
  • Two of the sacral GCT patients had an en bloc resection and neither developed a recurrence.
  • One sacral GCT patient was treated only with serial arterial embolization with good disease control.
  • One sacral GCT patient did not receive any treatment.
  • Eleven spinal GCT patients were treated with en bloc surgical resection and two developed a recurrence, the other two spinal GCT patients were treated with intralesional surgical resection and both developed a recurrence.
  • Giant cell tumors of the spine and sacrum should be managed with en bloc resections whenever possible as this provides the greatest chance for cure.
  • [MeSH-major] Bone Neoplasms / radiography. Cervical Vertebrae. Giant Cell Tumor of Bone / radiography. Lumbar Vertebrae. Sacrum. Spinal Neoplasms / radiography. Thoracic Vertebrae
  • [MeSH-minor] Adolescent. Adult. Biopsy. Embolization, Therapeutic. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Tomography, X-Ray Computed. Treatment Outcome. Young Adult

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  • (PMID = 21045974.001).
  • [ISSN] 1555-1377
  • [Journal-full-title] The Iowa orthopaedic journal
  • [ISO-abbreviation] Iowa Orthop J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2958273
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3. Lee CH, Espinosa I, Jensen KC, Subramanian S, Zhu SX, Varma S, Montgomery KD, Nielsen TO, van de Rijn M, West RB: Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone. Mod Pathol; 2008 May;21(5):531-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone.
  • Giant cell tumor of the bone (GCTOB) is a primary bone tumor that occurs mainly in young adults and is capable of locally aggressive growth.
  • Its histologic appearance can resemble a number of benign and malignant tumors but no useful diagnostic marker is known currently.
  • To identify diagnostic markers for this tumor, global gene expression profiling using cDNA microarray was performed on 6 fresh-frozen GCTOB, 3 aneurysmal bone cysts, 4 fibrous dysplasias and 12 giant cell tumors of tendon sheath/diffuse-type giant cell tumors.
  • Unsupervised hierarchical clustering separated the tumors based on their histopathologic types, and significance analysis of microarray identified several genes including TP73L (encoding the p63 protein) that are significantly highly expressed in GCTOB relative to these other tumors.
  • The diagnostic utility of p63 was subsequently confirmed using anti-p63 antibody on a series of 26 GCTOB, 25 aneurysmal bone cysts, 15 chondroblastomas, 13 giant cell reparative granulomas, 13 chondromyxoid fibromas, 4 brown tumors, 4 fibrous dysplasias, 53 giant cell tumors of tendon sheath/diffuse-type giant cell tumors and 385 additional mesenchymal tumors in tissue microarrays.
  • Strong p63 nuclear staining was present in 18 of 26 (69%) GCTOB, 3 of 15 (20%) chondroblastomas and in 1 of 25 (4%) aneurysmal bone cysts while none of the other tumors commonly considered in the differential diagnosis of GCTOB showed any detectable p63 staining.
  • Strong p63 staining is rare in bone and soft-tissue tumors in general.
  • [MeSH-major] Biomarkers, Tumor / genetics. Bone Neoplasms / genetics. Gene Expression Profiling. Giant Cell Tumor of Bone / genetics. Membrane Proteins / genetics

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  • (PMID = 18192965.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins
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4. Mena E, Martín-Miramon JC, Bernà L, Veintemillas M, Marín A, Valls R, Melloni P: [Giant cell tumor of the tendon sheath: characteristic findings of the bone scintigraphy and correlation with MRI]. Rev Esp Med Nucl; 2009 Sep-Oct;28(5):249-52
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  • [Title] [Giant cell tumor of the tendon sheath: characteristic findings of the bone scintigraphy and correlation with MRI].
  • [Transliterated title] Tumor de células gigantes de la vaina tendinosa: hallazgos característicos de la gammagrafía ósea y correlación con la RMN.
  • We report 3 cases of an unusual tumor, that is, the giant cell tumor of the tendon sheath.
  • The patients consulted due to the appearance of a well-defined, painless, soft tissue mass with mild-to-moderate inflammation located in the thumbs or toes.
  • These clinical data, together with the bone scan findings, oriented the diagnostic suspicion that was confirmed by a pathology study of the tumor after resection.
  • This work has aimed to review the characteristics of the bone scan (BS) image of this tumor and its correlation with the conventional X-ray imaging and magnetic resonance imaging (MRI).
  • [MeSH-major] Bone and Bones / radionuclide imaging. Giant Cell Tumors / pathology. Giant Cell Tumors / radionuclide imaging. Magnetic Resonance Imaging. Tendons

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  • (PMID = 19922843.001).
  • [ISSN] 0212-6982
  • [Journal-full-title] Revista española de medicina nuclear
  • [ISO-abbreviation] Rev Esp Med Nucl
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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5. Horvai AE, Kramer MJ, Garcia JJ, O'Donnell RJ: Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone. Mod Pathol; 2008 Apr;21(4):423-30
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  • [Title] Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone.
  • Giant-cell tumor of bone is considered a benign, locally aggressive and rarely metastasizing neoplasm of bone.
  • However, recent evidence suggests that activity of the telomerase enzyme complex correlates with recurrence in giant-cell tumor, although the subset of cells with telomerase activity in these heterogeneous tumors has not been defined.
  • In the present study, we investigated whether immunostaining for human telomerase reverse transcriptase, a component of the telomerase complex, correlates with outcome in giant-cell tumor and the distribution of telomerase reverse transcriptase staining in these tumors.
  • We analyzed 58 cases of giant-cell tumor for the presence and pattern of telomerase reverse transcriptase immunostaining, presence of soft tissue involvement and the type of initial surgery, and correlated these findings with recurrence-free survival and metastasis-free survival.
  • Specific staining with telomerase reverse transcriptase was present in 20 out of 58 tumors (35%) in the nuclei of mononuclear cells and, occasionally, osteoclast-like giant cells.
  • Furthermore, positive telomerase reverse transcriptase immunohistochemistry correlated with recurrence-free survival (P=0.02), whereas the presence of soft tissue extension (P=0.3) and the type of initial surgery (P=0.2) did not.
  • Therefore, telomerase reverse transcriptase expression may predict recurrence in giant-cell tumor insofar as positive immunostaining correlates with shorter recurrence-free survival and may be a useful prognostic marker to stratify patients to more aggressive treatment protocols.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bone Neoplasms / enzymology. Giant Cell Tumor of Bone / enzymology. Telomerase / biosynthesis
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Prognosis

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  • (PMID = 18204433.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
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6. Altaykan A, Yildiz K, Hapa O, Cukur S: Multifocal giant cell tumor of the tendon sheath occuring at different localizations of the same tendon of a finger: a case report and review of the literature. Eklem Hastalik Cerrahisi; 2009;20(2):119-23

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  • [Title] Multifocal giant cell tumor of the tendon sheath occuring at different localizations of the same tendon of a finger: a case report and review of the literature.
  • The giant cell tumor of the tendon sheath is regarded as one of the most common neoplasms of the hand.
  • This tumor usually manifests itself as a localized, solitary, painless and palpable subcutaneous nodule on the palmar aspect of a digit.
  • A multifocal origin of the tumor has rarely been reported in the literature before.
  • In this article we present a case of a giant cell tumor of the tendon sheath, in which two separate lesions developed simultaneously on the same tendon (flexor digitorum superficialis) of the little finger of the right hand together with a literature review about multifocal cases.
  • [MeSH-major] Fingers / pathology. Giant Cell Tumors / pathology. Tendons / pathology

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  • (PMID = 19619117.001).
  • [ISSN] 1309-0313
  • [Journal-full-title] Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery
  • [ISO-abbreviation] Eklem Hastalik Cerrahisi
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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7. Arredondo-Gómez E, Pasos Novelo FJ, Vargas Mena R: [Treatment of recurrent giant cell tumor of the tibia with en bloc resections, bone transport and arthrodesis using an AO type external fixations system. A case report]. Acta Ortop Mex; 2009 Mar-Apr;23(2):98-102
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  • [Title] [Treatment of recurrent giant cell tumor of the tibia with en bloc resections, bone transport and arthrodesis using an AO type external fixations system. A case report].
  • [Transliterated title] Resección en bloque, transporte óseo y artrodesis con fijador tubular AO del tumor de células gigantes recurrente de tibia. Reporte de un caso.
  • INTRODUCTION: The primary treatment for the giant cell tumor (GCT) at the knee level, both distal femur and proximal tibia remains curettage and application of methyl methacrylate.
  • CASE REPORT: We report a case of GCT that relapsed at proximal tibia in a stage III of Enneking, in a 26 year old patient, that was handled with en bloc resection, transportation and bone arthrodesis using an AO type tubular external fixator (Synthes).
  • After two years of evolution there was no evidence of tumor relapse, the limb was preserved and we obtained a solid arthrodesis, and an acceptable gait.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Neoplasm Recurrence, Local / surgery. Tibia

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  • (PMID = 19432367.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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8. Shimizu T, Uehara T, Akahane T, Isobe K, Arai H: Recurrence potential of diffuse-type giant cell tumor in the foot: radiologic and pathologic features. Foot Ankle Int; 2005 Jun;26(6):474-8
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  • [Title] Recurrence potential of diffuse-type giant cell tumor in the foot: radiologic and pathologic features.
  • BACKGROUND: Aggressive musculoskeletal tumors in the foot, such as diffuse-type giant cell tumors or extra-abdominal desmoid tumors, are difficult to treat because the foot does not have enough soft tissue to allow wide tumor resection.
  • We reviewed the clinical behavior of diffuse-type giant cell tumor in the foot and evaluated the recurrence potential of these tumors from radiologic and pathologic perspectives.
  • Radiologic studies, including sonography, computed tomography (CT), magnetic resonance imaging (MRI), and bone and gallium citrate scintigraphy, were obtained followed by surgical treatment and histologic evaluation of the tumor.
  • Although CT and MRI findings were similar in the recurrent and nonrecurrent tumors, marked differences were found between the two by scintigraphy; positive radiotracer uptake to the affected foot with gallium citrate scintigraphy was noted only in recurrent tumors, although positive accumulation was seen in all patients with bone scintigraphy.
  • Histologically, the necrotic area and mitotic activity were more apparent in recurrent than in the nonrecurrent tumors, and tumor cell dyscohesion was noted in the former, (the intercellular space was increased).
  • CONCLUSIONS: Repeated recurrence with tumor invasion into tarsal bone resulted in breakage of the tarsal arch that supports the body's weight.
  • Amputation would be necessary for patients in whom the disease had progressed to obtain local cure and relief of pain.
  • In the present study, we found two features of the recurrence potential of diffuse-type giant cell tumors: sparse cell to cell contact on pathologic examination and positive accumulation in the tumor on gallium citrate scintigraphy.
  • We concluded that giant cell tumors with these two features have a strong potential for local recurrence, and thus require intensive followup.
  • [MeSH-major] Foot Bones / pathology. Foot Diseases / pathology. Giant Cell Tumor of Bone / pathology. Neoplasm Recurrence, Local

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  • (PMID = 15960914.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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9. Saglik Y, Yildiz Y, Atalar H, Gunay C: The use of fibular autograft and ankle arthrodesis for aggressive giant cell tumor in the distal tibia: a case report. Foot Ankle Int; 2008 Apr;29(4):438-41
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  • [Title] The use of fibular autograft and ankle arthrodesis for aggressive giant cell tumor in the distal tibia: a case report.
  • The case describes successful distal tibial resection, fibular autograft, and ankle arthrodesis in two patients who had giant cell tumor in the distal tibia.
  • In conclusion, due to the large resection that is often necessary for aggressive tumors, fibular autograft and ankle arthrodesis may be a useful method in the distal tibia.
  • [MeSH-major] Bone Neoplasms / surgery. Fibula / transplantation. Giant Cell Tumor of Bone / surgery. Reconstructive Surgical Procedures / methods. Tibia / surgery

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  • (PMID = 18442462.001).
  • [ISSN] 1071-1007
  • [Journal-full-title] Foot & ankle international
  • [ISO-abbreviation] Foot Ankle Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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10. Zhang WG, Wang LD, Li J, Zhang YF, Liu Y, Wang FS: [Arthroscopic treatment of the giant cell tumor of tendon sheath in knee joint]. Zhonghua Wai Ke Za Zhi; 2006 Feb 15;44(4):258-9

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  • [Title] [Arthroscopic treatment of the giant cell tumor of tendon sheath in knee joint].
  • OBJECTIVE: To explore the technique of diagnosis and treatment of intra-articular giant cell tumor of tendon sheath (GCTTS) in knee joint, and to evaluate its clinical results.
  • Tumor wide resection and debriding the channel which tumor passed through are the key point to prevent the recurrence after operation.
  • [MeSH-major] Arthroscopy. Giant Cell Tumors / surgery. Muscle Neoplasms / surgery. Tendons / pathology

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  • (PMID = 16635371.001).
  • [ISSN] 0529-5815
  • [Journal-full-title] Zhonghua wai ke za zhi [Chinese journal of surgery]
  • [ISO-abbreviation] Zhonghua Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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11. Sakayama K, Sugawara Y, Kidani T, Miyawaki J, Fujibuchi T, Kamei S, Aizawa J, Yamamoto H: Diagnostic and therapeutic problems of giant cell tumor in the proximal femur. Arch Orthop Trauma Surg; 2007 Dec;127(10):867-72

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnostic and therapeutic problems of giant cell tumor in the proximal femur.
  • Primaly giant cell tumor of bone (GCT) in the proximal femur is relatively rare, and can prove difficult to diagnose, and can require therapeutic methods.
  • Tumors in the present study were limited to H1 and H2 according to the International Society of Limb Salvage (ISOLS) system.
  • Excisional biopsy is effective for surgery of GCT in the proximal femur.
  • [MeSH-major] Femoral Neoplasms / diagnosis. Femoral Neoplasms / surgery. Giant Cell Tumor of Bone / diagnosis. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Adult. Arthrodesis. Arthroplasty, Replacement, Hip / methods. Biopsy. Bone Cements / therapeutic use. Female. Femur / pathology. Femur / surgery. Hip Joint / surgery. Humans. Male. Neoplasm Recurrence, Local. Osteolysis / etiology

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  • (PMID = 17713773.001).
  • [ISSN] 0936-8051
  • [Journal-full-title] Archives of orthopaedic and trauma surgery
  • [ISO-abbreviation] Arch Orthop Trauma Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Bone Cements
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12. Gong LH, Sun XQ, Meng SQ, Huang XY: [Giant cell tumor of bone and malignancies in giant cell tumor: a clinicopathologic analysis]. Zhonghua Bing Li Xue Za Zhi; 2009 May;38(5):312-5
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  • [Title] [Giant cell tumor of bone and malignancies in giant cell tumor: a clinicopathologic analysis].
  • OBJECTIVE: To study the clinicopathologic features, diagnosis and differential diagnosis of malignancies in giant cell tumor (MGCT).
  • RESULTS: Thirteen cases of MGCT were found amongst a total of 603 cases of giant cell tumor encountered.
  • Six of the 13 cases represented concurrent malignancy in giant cell tumor while the remaining 7 cases was malignant transformation in recurrent giant cell tumor.
  • In concurrent MGCT, a high-grade sarcoma component was present in conjunction with the giant cell tumor component.
  • In malignant transformation of recurrent giant cell tumor, the original tumor was giant cell tumor and the recurrence showed features reminiscent of malignant fibrous histiocytoma.
  • CONCLUSIONS: The diagnosis of malignancies in giant cell tumor requires correlation of clinical, radiologic and pathologic features.
  • The entities need to be distinguished from other giant cell-rich tumors including primary malignant fibrous histiocytoma and giant cell osteosarcoma.
  • [MeSH-major] Bone Neoplasms / pathology. Cell Transformation, Neoplastic. Giant Cell Tumor of Bone / pathology. Histiocytoma, Malignant Fibrous / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Osteosarcoma / pathology. Sarcoma / pathology. Young Adult

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  • (PMID = 19575873.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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13. Doita M, Miyamoto H, Nishida K, Nabeshima Y, Yoshiya S, Kurosaka M: Giant-cell tumor of the tendon sheath involving the thoracic spine. J Spinal Disord Tech; 2005 Oct;18(5):445-8

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  • [Title] Giant-cell tumor of the tendon sheath involving the thoracic spine.
  • Giant-cell tumor of the tendon sheath is a common benign lesion of the synovial membrane that frequently occurs in the hand.
  • It is related to pigmented villonodular synovitis and the occurrence of pigmented villonodular synovitis or giant-cell tumor of the tendon sheath in the axial skeleton is very rare.
  • To data, only three cases of giant-cell tumor of the tendon sheath involving cervical spine have been reported, compared with 26 cases of pigmented villonodular synovitis.
  • Pigmented villonodular synovitis involving the thoracic spine is also extremely rare and our case represents the first reported case of a giant-cell tumor of the tendon sheath involving the thoracic spine.
  • Postoperatively, the patient recovered with complete relief of symptoms, there was no evidence of recurrent disease or regrowth of the residual lesion, as investigated by plain radiographs and MRI within a follow-up period of two years.
  • Although giant-cell tumor of the tendon sheath in the thoracic spine may be extremely uncommon, it should be considered in the differential diagnosis, especially when a benign lesion appears to originate in the face joint.
  • [MeSH-major] Giant Cell Tumors / radiography. Giant Cell Tumors / surgery. Soft Tissue Neoplasms / radiography. Soft Tissue Neoplasms / surgery. Tendons. Thoracic Vertebrae

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  • (PMID = 16189458.001).
  • [ISSN] 1536-0652
  • [Journal-full-title] Journal of spinal disorders & techniques
  • [ISO-abbreviation] J Spinal Disord Tech
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Thomas DM, Chawla S, Skubitz K, Staddon A, Henshaw R, Blay J, Smith J, Ye Z, Roudier M, Jun S: Denosumab for the treatment of giant cell tumor (GCT) of bone: Final results from a proof-of-concept, phase II study. J Clin Oncol; 2009 May 20;27(15_suppl):10510

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Denosumab for the treatment of giant cell tumor (GCT) of bone: Final results from a proof-of-concept, phase II study.
  • : 10510 Background: GCT of bone is a primary osteolytic bone tumor with low metastatic potential that is associated with significant skeletal morbidity.
  • GCT is rich in stromal cells that express RANKL, a key mediator of osteoclast activation.
  • In this open-label, study, we investigated whether denosumab, a fully human monoclonal antibody against RANKL, could have a potential therapeutic effect on giant cell histology for patients with GCT.
  • METHODS: In this single-arm study, 37 patients with measurable or unresectable GCT received denosumab 120 mg subcutaneously once monthly with loading doses on days 8 and 15 of month 1.
  • The primary endpoint was the proportion of patients with a tumor response (≥90% elimination of giant cells or no radiographic progression of the target lesion) at week 25 as assessed by histology and CT or MRI.
  • RESULTS: Thirty of 35 patients (86%; 95% CI 70%-95%) had a tumor response: 20 of 20 by histology and 10 of 15 by radiology.
  • CONCLUSIONS: In this study, 86% of patients with measurable or unresectable GCT experienced a tumor response with denosumab.
  • Further clinical trials of denosumab as a new therapy for GCT are warranted.

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  • (PMID = 27963683.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Arpornchayanon O, Leerapun T: Effectiveness of intravenous bisphosphonate in treatment of giant cell tumor: a case report and review of the literature. J Med Assoc Thai; 2008 Oct;91(10):1609-12

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effectiveness of intravenous bisphosphonate in treatment of giant cell tumor: a case report and review of the literature.
  • Giant cell tumor is a benign locally aggressive tumor.
  • Surgical treatment of giant cell tumor at the sacrum is associated with high morbidity, and local recurrence.
  • The authors present a case of giant cell tumor at the sacrum treated with intravenous 4 mg zoledronate every 4 weeks for seven courses followed with curettage and cement implantation.
  • From the present study, the authors demonstrate the effectiveness of zoledronate for treatment of giant cell tumor at the sacrum.
  • [MeSH-major] Bone Density Conservation Agents / therapeutic use. Diphosphonates / therapeutic use. Giant Cell Tumor of Bone / drug therapy. Imidazoles / therapeutic use. Sacrum / pathology

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  • (PMID = 18972907.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Thailand
  • [Chemical-registry-number] 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 0 / Imidazoles; 6XC1PAD3KF / zoledronic acid
  • [Number-of-references] 15
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16. Alacacioğlu A, Bengi G, Oztop I, Canda T, Balci P, Osma E, Yilmaz U: Metastasis of giant cell tumor to the breast: case report and review of the literature. Tumori; 2006 Jul-Aug;92(4):351-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastasis of giant cell tumor to the breast: case report and review of the literature.
  • Breast cancer is the most common type of malignancy in women.
  • Of all breast cancers, 0.5-3% involve metastasis of a non-breast malignancy to the breast.
  • Metastasis of soft tissue tumors to the breast is rarely seen.
  • In particular, metastasis of a giant cell tumor to the breast has never been reported in the literature.
  • We present here a case of breast metastasis in a 44-year-old woman with a diagnosis of malignant giant cell tumor originating from the distal radius and metastatic to the lung, who had been treated with radiotherapy, surgery and chemotherapy.
  • [MeSH-major] Bone Neoplasms / pathology. Breast Neoplasms / secondary. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary. Radius

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  • (PMID = 17036529.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 9
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17. Nishimura K, Satoh T, Maesawa C, Ishijima K, Sato H: Giant cell tumor of the larynx: a case report and review of the literature. Am J Otolaryngol; 2007 Nov-Dec;28(6):436-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the larynx: a case report and review of the literature.
  • Giant cell tumors are benign tumors commonly found in the long bones.
  • Rarely, they may occur in the larynx, and patients with such tumors may present with hoarseness and anterior neck swelling.
  • Since Wessely reported the first case of laryngeal giant cell tumor in 1940, 30 cases have been identified.
  • Herein, we present a case of a 31-year-old man with giant cell tumor of the larynx successfully treated via the hemilaryngectomy approach.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Giant Cell Tumors / therapy. Laryngeal Neoplasms / diagnosis. Laryngeal Neoplasms / therapy

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  • (PMID = 17980781.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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18. Kadivar M, Nilipour Y, Sadeghipour A: Osteoclast-like giant-cell tumor of the parotid with salivary duct carcinoma: case report and cytologic, histologic, and immunohistochemical findings. Ear Nose Throat J; 2007 Oct;86(10):628-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Osteoclast-like giant-cell tumor of the parotid with salivary duct carcinoma: case report and cytologic, histologic, and immunohistochemical findings.
  • Primary giant-cell tumor of the salivary gland is a rare lesion with an incompletely characterized histogenesis.
  • As far as we know, ours is the only reported case of a primary giant-cell tumor of the salivary gland in which the patient presented with lymph node metastasis.
  • Because so little is known about giant-cell tumor of the salivary gland, we use the occasion of this case report to describe the cytologic, histologic, and immunohistochemical characteristics that we observed.
  • [MeSH-major] Carcinoma / immunology. Carcinoma / pathology. Giant Cell Tumors / immunology. Giant Cell Tumors / pathology. Osteoclasts / pathology. Salivary Gland Neoplasms / immunology. Salivary Gland Neoplasms / pathology

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  • (PMID = 17990687.001).
  • [ISSN] 0145-5613
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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19. Guo W, Ji T, Tang X, Yang Y: Outcome of conservative surgery for giant cell tumor of the sacrum. Spine (Phila Pa 1976); 2009 May 1;34(10):1025-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Outcome of conservative surgery for giant cell tumor of the sacrum.
  • OBJECTIVE: To estimate the clinical outcome of conservative surgery (intralesional curettage or partial excision) aided by effective intraoperative hemorrhage control in patients with giant cell tumors of the sacrum.
  • SUMMARY OF BACKGROUND DATA: Giant cell tumors of the sacrum present a challenging therapeutic problem.
  • METHODS: The clinical records of 24 patients with an average age of 35 years who had undergone conservative surgery for sacral giant cell tumor between 1996 and 2005 were evaluated retrospectively.
  • The disease onset, tumor size, operation records, complications, follow-up status, and functional outcome were analyzed.
  • CONCLUSION: Considering the acceptable local recurrence rate, conservative surgery aided by effective control of intraoperative hemorrhage should be considered as an alternative procedure for patients with giant cell tumors of the sacrum.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / surgery. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery. Sacrum / pathology. Sacrum / surgery
  • [MeSH-minor] Adolescent. Adult. Aorta, Abdominal / surgery. Female. Hemorrhage / etiology. Hemorrhage / physiopathology. Hemorrhage / prevention & control. Humans. Intraoperative Complications / etiology. Intraoperative Complications / prevention & control. Male. Middle Aged. Neoplasm Recurrence, Local / epidemiology. Neurosurgical Procedures / methods. Neurosurgical Procedures / statistics & numerical data. Postoperative Complications / etiology. Postoperative Complications / physiopathology. Retrospective Studies. Surgical Instruments. Treatment Outcome. Young Adult

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  • (PMID = 19404178.001).
  • [ISSN] 1528-1159
  • [Journal-full-title] Spine
  • [ISO-abbreviation] Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Li D, Feng F, Gu J: [Vascularized fibular combined with iliac grafting to repair bone defect after tumor extensive resection for giant cell tumor of bone around knee]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2006 Oct;20(10):981-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vascularized fibular combined with iliac grafting to repair bone defect after tumor extensive resection for giant cell tumor of bone around knee].
  • OBJECTIVE: To study the method and effect of the vascularized fibular combined with iliac grafting after the tumor extensive resection for giant cell tumor of the bone around the knee.
  • METHODS: Twenty-five patients with giant cell tumor of the bone around the knee were reviewed, who had been admitted to our hospital from October 1996 to November 2002, including 17 patients undergoing the fibular and iliac transplantation with the vessels anastomosed after the extensive excision of the bone tumor.
  • Of the patients, 9 were treated by the vascularized fibular combined with iliac grafting in the proximal tibia after the tumor extensive resection, and 8 were treated by the distal femur reconstruction by the operation.
  • The following items were also analyzed: postoperative infection, growth of the bone graft, rate of local recurrence, tumor metastasis, and bone death.
  • CONCLUSION: The vascularized fibular combined with iliac grafting after the tumor extensive resection to treat giant cell tumor of the bone around the knee has advantages of complete resection of the tumor and well-restored or reconstructed structure and function of the knee joint.
  • [MeSH-minor] Adolescent. Adult. Bone Neoplasms / surgery. Bone Transplantation. Female. Follow-Up Studies. Giant Cell Tumor of Bone / surgery. Humans. Knee Joint. Male. Postoperative Period

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  • (PMID = 17140068.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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21. Trabelsi A, Hammedi F, Slama A, Abdelkarim SB, Beïzig N, Khochtali H, Taher YM, Korbi S: Giant cell tumor of soft tissue of neck: a case report. N Am J Med Sci; 2009 Nov;1(6):319-20

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of soft tissue of neck: a case report.
  • CONTEXT: Giant cell tumor of soft tissue is a rare primary soft tissue tumor with low malignant potential.
  • It is clinically and pathologically similar to the giant cell tumor of the bone.
  • CASE REPORT: We report a case of a 28-year-old man complaining of a painless solitary nodule arising in the spinal muscle of the neck.
  • Computed tomography suggested a neurogenic tumor, but the diagnosis of giant cell tumor was confirmed after detailed pathological examination.
  • The patient remains disease free five months after diagnosis.
  • CONCLUSION: It is important to recognize this pathological entity in order to avoid misdiagnosis with other fibrous tumors associated with giant cells.

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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of giant cell tumor in atlas].
  • We report a rare case of giant cell tumor in the atlas.
  • The preoperative magnetic resonance images showed a tumor mixed with solid and cystic components in the right side of the atlas.
  • Preoperative biopsy led to the pathological diagnosis of giant cell tumor with multinuclear giant cells and mononuclear stromal cells.
  • A preoperative vertebral angiogram demonstrated tumor stain supplied from the muscular branches.
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  • Although the symptoms disappeared completely after surgery, regrowth of tumor was observed in follow-up MRI 4 months after the operation.
  • Then, the size of the tumor has not changed in the 1.5 years since the operation.
  • [MeSH-major] Cervical Atlas. Giant Cell Tumors / surgery. Spinal Neoplasms / surgery

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  • (PMID = 16095213.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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23. Salerno M, Avnet S, Alberghini M, Giunti A, Baldini N: Histogenetic characterization of giant cell tumor of bone. Clin Orthop Relat Res; 2008 Sep;466(9):2081-91
MedlinePlus Health Information. consumer health - Bone Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histogenetic characterization of giant cell tumor of bone.
  • The unpredictable behavior of giant cell tumor (GCT) parallels its controversial histogenesis.
  • Multinucleated giant cells, stromal cells, and CD68(+) monocytes/macrophages are the three elements that interact in GCT.
  • We compared the ability of stromal cells and normal mesenchymal stromal cells to differentiate into osteoblasts.
  • Stromal cells and mesenchymal cells had similar proliferation rates and lifespans.
  • Although stromal cells expressed early osteogenic markers, they were unable to differentiate into osteoblasts but they did express intracellular adhesion molecule-1, a marker of bone-lining cells.
  • Stromal cells may be either immature proliferating osteogenic elements or specialized osteoblast-like cells that fail to show neoplastic features but can induce the differentiation of osteoclast precursors.
  • They might be secondarily induced to proliferate by a paracrine effect induced by monocyte-macrophages and/or giant cells.
  • The increased number of giant cells in GCT may be secondary to an autocrine circuit mediated by the receptor activator of nuclear factor kB.
  • [MeSH-major] Bone Neoplasms / pathology. Cell Transformation, Neoplastic / pathology. Giant Cell Tumor of Bone / pathology. Stromal Cells / pathology
  • [MeSH-minor] Adolescent. Adult. Cell Differentiation / physiology. Cell Proliferation. Coculture Techniques. Female. Humans. Hyperplasia. Male. Middle Aged

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  • (PMID = 18543051.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2492994
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24. Cui Y, Zong XY, Hao SY, Zhang YZ: [Microsurgical treatment of giant cell tumor of skull]. Zhonghua Yi Xue Za Zhi; 2010 Jun 15;90(23):1622-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Microsurgical treatment of giant cell tumor of skull].
  • OBJECTIVE: To explore the diagnosis and microsurgical treatment of giant cell tumor (GCT) of skull.
  • METHODS: The investigators reviewed the clinical features, operative approach and prognosis of 23 consecutive cases of GCT of skull operated at our department between July 2000 and November 2008.
  • RESULTS: Headache was the most common presenting symptom (86.96%) found among the patients with GCT of skull.
  • Among these cases, 10 tumors occurred in sphenoid bone, 9 in temporal bone, 3 in posterior fossa and 1 in frontal bone.
  • CONCLUSION: GCT of skull is a generally low-degree malignancy showing a local bone invasion mostly in sphenoid and temporal bones.
  • [MeSH-major] Giant Cell Tumors / surgery. Microsurgery. Skull Neoplasms / surgery

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  • (PMID = 20979751.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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25. Muramatsu K, Ihara K, Taguchi T: Treatment of giant cell tumor of long bones: clinical outcome and reconstructive strategy for lower and upper limbs. Orthopedics; 2009 Jul;32(7):491
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Treatment of giant cell tumor of long bones: clinical outcome and reconstructive strategy for lower and upper limbs.
  • Giant cell tumor of bone is a rare and unpredictable lesion.
  • Twenty-three consecutive cases of giant cell tumor of long bones were treated in 10 years.
  • The most common tumor sites were the proximal tibia (10 cases), distal femur (8), and distal radius (3).
  • Functional outcomes as evaluated by the Musculoskeletal Tumor Society measure were successful, with an average score of 26.6 points (range, 22-30 points).
  • For giant cell tumor of the upper limb or for young patients, biological reconstruction should be applied.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Lower Extremity / surgery. Reconstructive Surgical Procedures / methods. Upper Extremity / surgery

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  • (PMID = 19634852.001).
  • [ISSN] 1938-2367
  • [Journal-full-title] Orthopedics
  • [ISO-abbreviation] Orthopedics
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] United States
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26. Suzuki Y, Nishida Y, Yamada Y, Tsukushi S, Sugiura H, Nakashima H, Ishiguro N: Re-operation results in osteoarthritic change of knee joints in patients with giant cell tumor of bone. Knee; 2007 Oct;14(5):369-74
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Re-operation results in osteoarthritic change of knee joints in patients with giant cell tumor of bone.
  • Giant cell tumor of bone occasionally results in secondary osteoarthritic changes in adjacent joints.
  • The purpose of this study was to determine the factors associated with the development of degenerative arthritis in surgically treated patients with giant cell tumor of the distal femur or proximal tibia and the effect of residual subchondral bone thickness on the location of recurrent giant cell tumor.
  • We retrospectively studied 30 patients with giant cell tumor of bone arising around the knee joint treated with intralesional curettage, high-speed burring, and electrocauterization, followed by filling with polymethylmethacrylate or autogenous bone graft.
  • There was no significant difference in factors of age, gender, tumor location, residual thickness of subchondral bone, or Campanacci grade correlated with the recurrence.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Neoplasm Recurrence, Local / surgery. Osteoarthritis, Knee / etiology. Osteoarthritis, Knee / surgery

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  • (PMID = 17601737.001).
  • [ISSN] 0968-0160
  • [Journal-full-title] The Knee
  • [ISO-abbreviation] Knee
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Cements; 9011-14-7 / Polymethyl Methacrylate
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27. Saikia KC, Borgohain M, Bhuyan SK, Goswami S, Bora A, Ahmed F: Resection-reconstruction arthroplasty for giant cell tumor of distal radius. Indian J Orthop; 2010 Jul;44(3):327-32

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Resection-reconstruction arthroplasty for giant cell tumor of distal radius.
  • BACKGROUND: Giant cell tumor (GCT) of the distal radius poses problems for reconstruction after resection.
  • MATERIALS AND METHODS: Twenty-four cases of giant cell tumor of the distal radius (mean age 32 years, mean follow-up 6.6 years) treated by en-bloc resection and reconstruction arthroplasty using autogenous non-vascularized ipsilateral fibular graft with a minimum followup of two years have been included in this retrospective study.
  • Routine radiographs and clinical assessments regarding pain, instability, recurrence, hand grip strength and functional status were done at regular intervals and functional results were assessed using (musculoskeletal tumor society) MSTS-87 scoring.

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  • (PMID = 20697488.001).
  • [ISSN] 1998-3727
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2911935
  • [Keywords] NOTNLM ; Distal radius / giant cell tumor / resection reconstruction
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28. Kobayashi S, Hara M, Yano M, Tateyama H, Shibamoto Y: Dendriform pulmonary ossification in a patient with a past history of giant cell tumor in femur. J Thorac Imaging; 2008 Feb;23(1):47-9
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  • [Title] Dendriform pulmonary ossification in a patient with a past history of giant cell tumor in femur.
  • Diffuse pulmonary ossification most commonly occurs in men in their fifth and sixth decades of life and is usually associated with diffuse and chronic lung disease, cardiac disease, or other systemic disorders.
  • In this report, we describe a case of dendriform pulmonary ossification with a past history of giant cell tumor in the femur that occurred 8 years before.
  • We speculate that the pulmonary ossification might have been due to dissemination of bone cells into the pulmonary circulation during bone curettage.
  • [MeSH-major] Bone Neoplasms / pathology. Femur / pathology. Giant Cell Tumor of Bone / pathology. Lung / pathology. Lung Diseases / diagnosis. Ossification, Heterotopic / diagnosis

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  • (PMID = 18347521.001).
  • [ISSN] 0883-5993
  • [Journal-full-title] Journal of thoracic imaging
  • [ISO-abbreviation] J Thorac Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Minami A, Iwasaki N, Nishida K, Motomiya M, Yamada K, Momma D: Giant-cell tumor of the distal ulna treated by wide resection and ulnar support reconstruction: a case report. Case Rep Med; 2010;2010:871278

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant-cell tumor of the distal ulna treated by wide resection and ulnar support reconstruction: a case report.
  • Giant-cell tumor of bone occurred in the distal end of the ulna is extremely uncommon.
  • A 23-year-old male had a giant-cell tumor occurred in the distal end of the ulna.
  • After wide resection of the distal segment of the ulna including giant-cell tumor, ulnar components of the wrist joint were reconstructed with modified Sauvé-Kapandji procedure using the iliac bone graft, preserving the triangular fibrocartilage complex and ulnar collateral ligament in order to maintain ulnar support of the wrist, and the proximal stump of the resected ulna was stabilized by tenodesis using the extensor carpi ulnaris tendon.
  • Postoperative X-rays showed no abnormal findings including recurrence of the giant-cell tumor and ulnar translation of the entire carpus.

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  • (PMID = 20592994.001).
  • [ISSN] 1687-9635
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2892703
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30. Zhang Z, Zhu B, Sun T: [Case analysis on treatment and recurrence of giant cell tumor of bone]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2006 Oct;20(10):1007-10

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  • [Title] [Case analysis on treatment and recurrence of giant cell tumor of bone].
  • OBJECTIVE: To analyze the clinical features, treatment methods, and recurrence factors of giant cell tumor of the bone and to investigate the surgical therapy choice for the tumor around the knees.
  • METHODS: Thirty-eight patients (13 males and 25 females; average age 31.1 years, range 14-59 years) with giant cell tumor of the bone were treated and followed up from January 1993 to January 2005.
  • The intralesional excision (curettage) with the bone grafting was performed on 4 patients; the curettage with some adjuvant treatments (high-speed burring, phenol, alcohol, cement, hydrogen peroxide, 50% ZnCl2, 3% iodine tincture, or bone cement) was used in 26 patients; and resection of the whole tumor was performed on 8 patients.
  • RESULTS: The follow-up of the 38 patients for 12-144 months (average, 67 months) revealed that giant cell tumor of the bone was found around the knees in 29 of the 38 patients (13 at the distal femur, 16 at the proximal tibia), at the proximal femur in 2, at the proximal ulna in 2, at the distal radius in 2, at the sacroiliac area in 2, and at lumbar spine in 1.
  • Of the 38 patients, 4 had a recurrence after simple curettage, 8 had no recurrence after resection of the whole tumor, and 8 of the remaining 26 patients had a recurrence after curettage with some adjuvant treatments.
  • Of the patients with the recurrence, 12 underwent reoperations (8 by the total resection of the recurrent tumor, 4 by the curettage with adjuvant treatments), and there was no recurrence after the reoperation.
  • CONCLUSION: Giant cell tumor of the bone usually recurs around the knee joint, especially at the proximal tibia, usually graded as Grade II or III by the Campanacci's radiological grading system.
  • Simple curettage has a higher recurrence rate; therefore, extensive curettage and resection of the lesions combined with some adjuvant treatments after the correct diagnosis can be used to reduce the high recurrence rate of giant cell tumor of the bone.
  • [MeSH-major] Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery. Neoplasm Recurrence, Local

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  • (PMID = 17140075.001).
  • [ISSN] 1002-1892
  • [Journal-full-title] Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
  • [ISO-abbreviation] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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31. Grabellus F, von Winterfeld F, Sheu SY, Metz KA, Jahnke K, Schmid KW: Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapy. Virchows Arch; 2006 Jun;448(6):847-51
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  • [Title] Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapy.
  • Giant cell tumor of soft tissue with low malignant potential (GCT-ST) is a low-grade, primary soft tissue sarcoma with histological and clinical features similar to giant cell tumor of the bone.
  • The main tumor localizations are the extremities, but it may also occur in the head and neck region.
  • GCT-ST shows a recurrence rate of approximately 15%, but it very rarely metastasizes.
  • We report of a GCT-ST of low malignant potential, which developed under long-term immunosuppression in a patient 12 years after heart transplantation.
  • The tumor presented with an unusual aggressive course and metastatic site: the parotid gland.
  • [MeSH-major] Giant Cell Tumors / secondary. Immunocompromised Host. Immunosuppressive Agents / adverse effects. Parotid Neoplasms / secondary. Postoperative Complications. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Heart Transplantation. Humans. Immunosuppression. Male. Neoplasm Recurrence, Local

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  • (PMID = 16596381.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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32. Matsumoto M, Ishii K, Takaishi H, Nakamura M, Morioka H, Chiba K, Takahata T, Toyama Y: Extensive total spondylectomy for recurrent giant cell tumor in the thoracic spine. Case report. J Neurosurg Spine; 2007 Jun;6(6):600-5
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  • [Title] Extensive total spondylectomy for recurrent giant cell tumor in the thoracic spine. Case report.
  • The authors report the case of a 47-year-old woman who harbored a giant cell tumor at the T-5 level.
  • She had undergone curettage of the tumor via a combined anterior and posterior approach at a regional hospital and was later referred to the authors' institution for treatment after the tumor recurred.
  • On examination she exhibited progressive paraparesis and was nonambulatory due to cord compression caused by the tumor, which had invaded the spinal canal and extended to the right paravertebral muscles and right thoracic cavity.
  • The tumor, together with a portion of the dura mater, pleura, and muscles, was resected en bloc from T-4 to T-6.
  • Two and a half years after surgery, the patient was tumor free.
  • En bloc resection of a recurrent giant cell tumor was successfully achieved through a single posterior approach.
  • [MeSH-major] Giant Cell Tumors / surgery. Neoplasm Recurrence, Local / surgery. Orthopedic Procedures / methods. Spinal Neoplasms / surgery. Thoracic Vertebrae / surgery
  • [MeSH-minor] Bone Nails. Bone Screws. Female. Humans. Internal Fixators. Middle Aged. Neoplasm Invasiveness / diagnosis. Paraplegia / etiology. Reoperation. Spinal Cord Compression / complications. Spinal Cord Compression / etiology. Treatment Outcome

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  • (PMID = 17561753.001).
  • [ISSN] 1547-5654
  • [Journal-full-title] Journal of neurosurgery. Spine
  • [ISO-abbreviation] J Neurosurg Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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33. Sah PL, Sharma R, Kandpal H, Seith A, Rastogi S, Bandhu S, Jagannathan NR: In vivo proton spectroscopy of giant cell tumor of the bone. AJR Am J Roentgenol; 2008 Feb;190(2):W133-9
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  • [Title] In vivo proton spectroscopy of giant cell tumor of the bone.
  • OBJECTIVE: The proton MR spectroscopic finding of elevated choline has been reported to be useful in the differentiation of malignant from benign musculoskeletal tumors.
  • This study was designed to evaluate the MR spectroscopy features of giant cell tumor (GCT) of the bone, primarily to determine whether the presence of choline is a frequent occurrence in these tumors and whether MR spectroscopy features can be correlated with clinical, radiologic, and histopathologic findings.
  • SUBJECTS AND METHODS: MRI, dynamic contrast-enhanced MRI, and proton MR spectroscopy were performed in 33 patients with bone tumors on a 1.5-T MR scanner.
  • Of these, 12 patients who had GCT of the bone form the subject material for this study.
  • RESULTS: Although all 12 tumors were benign on histopathology, four had elevated choline levels.
  • As opposed to this, only three of the eight (37.5%) tumors without a choline peak had an aggressive radiographic appearance.
  • Except for a single case, all tumors showed early enhancement and washout of contrast material on dynamic MRI.
  • CONCLUSION: The results of this study indicate that GCT of bone may show raised choline levels on proton MR spectroscopy.
  • This finding is not an indicator of malignancy in these tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bone Neoplasms / diagnosis. Bone Neoplasms / metabolism. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / metabolism. Choline / analysis. Magnetic Resonance Spectroscopy / methods

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  • (PMID = 18212197.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Protons; N91BDP6H0X / Choline
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34. Karamanakos PN, Jaaskelainen JE, Alafuzoff I, Pirinen E, Vanninen R, Silvennoinen S, Sankilampi U, Immonen A: Malignant giant cell tumor in the posterior fossa of a neonate. J Neurosurg Pediatr; 2010 Mar;5(3):277-82
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  • [Title] Malignant giant cell tumor in the posterior fossa of a neonate.
  • Giant cell tumors (GCTs) of the bone are rare, usually benign but locally aggressive neoplasms that primarily occur in the epiphyses of long bones.
  • These tumors usually affect young adults, and few reports in children have been published.
  • Herein, the authors present a case of a highly aggressive primary malignant GCT of the posterior fossa in a 5-week old preterm infant.
  • One month after the gross-total resection of the tumor found in the bone, the infant's condition rapidly deteriorated and she died.
  • Magnetic resonance imaging and postmortem examination revealed a tumor larger than it had been before the operation, with expansion toward the brain.
  • To the best of the authors' knowledge, this is the youngest patient reported with a primary malignant GCT of the skull, and actually the first case in a pediatric patient.
  • In addition, the extremely high growth rate of the tumor in the postoperative period renders this case the most aggressive primary malignant GCT of the cranium described so far.
  • [MeSH-major] Cranial Fossa, Posterior. Giant Cell Tumor of Bone / pathology. Infant, Premature, Diseases / pathology. Skull Base Neoplasms / pathology

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  • (PMID = 20192645.001).
  • [ISSN] 1933-0715
  • [Journal-full-title] Journal of neurosurgery. Pediatrics
  • [ISO-abbreviation] J Neurosurg Pediatr
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Protsenko VV, Tolstopiatov BA: [Application of cryodestruction in the treatment of the bone giant cell tumor]. Klin Khir; 2008 Jan;(1):53-5
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  • [Title] [Application of cryodestruction in the treatment of the bone giant cell tumor].
  • In 25 patients in the Division of tumors of the support-movement apparatus the osteoplastic operations were performed, using intraoperative cryodestruction, after excision of the giant cell tumor of the bone.
  • During the patients observation follow-up postoperative complications, recurrences and metastases of the tumor were not revealed.

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  • (PMID = 18610858.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
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36. Vergara HF, Ortiz DA, Martínez BH, Mosiñoz RM, Arellano JA: [Hand reconstructive surgery secondary to giant cell tumor]. Acta Ortop Mex; 2010 Sep-Oct;24(5):345-50
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  • [Title] [Hand reconstructive surgery secondary to giant cell tumor].
  • [Transliterated title] Cirugía reconstructiva de mano secundario a tumor de células gigantes.
  • The giant cell tumor of the bone is a neoplastic low grade lesion that usually appears in the epiphyseal or metaphyseal region of the long bones.
  • It is thought to represent approximately 19% of the benign bone tumors and 9% of all the primary bone tumors, according to a review by Schajowicz.
  • The treatment of the giant cell tumor is controversial and the literature is confusing.
  • The giant cell tumor is located mainly in the hand.
  • Its potential aggressiveness makes us consider it in the differential diagnosis of the tumor lesions affecting the hand.
  • The purpose of this research work is to describe our experience with the treatment of the giant cell tumor in three cases that presented as a lytic, expansive lesion affecting the bones of the hand.
  • They were treated with tumor resection and a bone graft to fill the defect.
  • [MeSH-major] Bone Neoplasms / surgery. Finger Phalanges. Giant Cell Tumor of Bone / surgery

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  • (PMID = 21246807.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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37. Vargas Vázquez R: [Use of a prosthesis after resection of a giant cell tumor of the knee]. Acta Ortop Mex; 2010 May-Jun;24(3):151-8
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  • [Title] [Use of a prosthesis after resection of a giant cell tumor of the knee].
  • [Transliterated title] Uso de prótesis después de resección de tumor de células gigantes en rodilla.
  • OBJECTIVE: Show the efficacy of a tumor prosthesis after the resection of a giant cell knee tumor in the proximal tibia and the recovery of knee function.
  • MATERIAL AND METHODS: This is a report of a retrospective observational clinical case of a male, 36-year-old patient with history of left knee arthrodesis in 1996 following the resection of a giant cell tumor in the distal femur.
  • The latter relapsed in 2004 and a solitary pulmonary tumor node was detected.
  • Broad resection of the femur and the arthrodesed tibia was performed together with the placement of a tumor prosthesis.
  • RESULTS: At the 20th postoperative month the patient had remission of the pulmonary node, knee function with passive flexion of 120 degrees and total extension, gait without limitations, no pain, a Musculoskeletal Tumor Society functional knee score of 28 and a Knee Society score of 95.
  • CONCLUSIONS: The resection of the arthrodesis zone and the giant cell tumor achieved the double goal of erradicating the tumor and recovering the knee mobility after 10 years of arthrodesis, which led to a very satisfied patient capable of resuming his activities.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Knee Prosthesis. Tibia

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  • (PMID = 20836369.001).
  • [ISSN] 2306-4102
  • [Journal-full-title] Acta ortopédica mexicana
  • [ISO-abbreviation] Acta Ortop Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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38. Tse LF, Wong KC, Kumta SM, Huang L, Chow TC, Griffith JF: Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control study. Bone; 2008 Jan;42(1):68-73
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  • [Title] Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control study.
  • BACKGROUND: Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor that is characterized by the presence of mononuclear stromal cells and multinucleated giant cells.
  • Although topical adjuvants have been used in the past, local recurrence following intralesional excision of GCT of bone continues to remain a problem.
  • Furthermore in vitro studies have shown that bisphosphonates also induce apoptosis in GCT stromal cells.
  • Therefore our clinical study aims to investigate whether the administration of bisphosphonate as an adjuvant can further decrease local recurrence following the surgical treatment of GCT of bone.
  • Forty-four patients with histological diagnosed appendicular GCT were included.
  • CONCLUSION: Clinical use of bisphosphonates as an adjuvant therapy for giant cell tumor of bone demonstrated a lower local recurrence rate.
  • [MeSH-major] Bone Neoplasms. Diphosphonates / pharmacology. Extremities / pathology. Giant Cell Tumor of Bone. Neoplasm Recurrence, Local / prevention & control

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  • (PMID = 17962092.001).
  • [ISSN] 8756-3282
  • [Journal-full-title] Bone
  • [ISO-abbreviation] Bone
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Diphosphonates
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39. Selek H, Ozer H, Turanli S, Erdem O: Giant cell tumor of the talar neck. J Am Podiatr Med Assoc; 2007 May-Jun;97(3):225-8
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  • [Title] Giant cell tumor of the talar neck.
  • We describe a patient with a giant cell tumor in the talar head and neck of the left foot who was diagnosed as having osteochondritis dissecans and treated with arthroscopic drilling in this same location 3 years earlier.
  • Giant cell tumors can be confused with several conditions, including giant cell reparative granulomas, brown tumors, and aneurysmal bone cysts.
  • Giant cell tumors of bone typically occur in the epiphysis of long bones, including the distal femur and proximal tibia.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Talus

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  • (PMID = 17507533.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Kapoor SK, Jain V, Agrawal M, Singh S, Mandal AK: Primary malignant giant cell tumor of bone: a series of three rare cases. J Surg Orthop Adv; 2007;16(2):89-92
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  • [Title] Primary malignant giant cell tumor of bone: a series of three rare cases.
  • The purpose of this research was to study incidence; clinical, histological, and radiological features; and outcome of primary malignant giant cell tumor (PMGCT).
  • The authors retrospectively reviewed all cases of giant cell tumor (GCT) in which a diagnosis of GCT was related to sarcoma treated in their department between 1997 and 2004.
  • In these three cases of PMGCT, the initial clinical and radiological findings were the same as those for benign giant cell tumor.
  • Wide excision of the tumor was performed in all three cases.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis

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  • (PMID = 17592717.001).
  • [ISSN] 1548-825X
  • [Journal-full-title] Journal of surgical orthopaedic advances
  • [ISO-abbreviation] J Surg Orthop Adv
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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41. Riddle ND, Yamauchi H, Caracciolo JT, Cheong D, Khakpour N, Bui MM: Giant cell tumor of the anterior rib masquerading as a breast mass: a case report and review of current literature. Cases J; 2010;3:51
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  • [Title] Giant cell tumor of the anterior rib masquerading as a breast mass: a case report and review of current literature.
  • INTRODUCTION: Giant cell tumor (GCT) is an aggressive, but usually benign bone neoplasm most commonly arising in the metaphysis/epiphyses of long bones.
  • While they are categorized as benign tumors, they can be locally aggressive and clinically have metastatic potential.
  • The most common locations of this tumor include the distal femur, proximal tibia, and distal radius.
  • We report a GCT arising in an atypical location and mimicking a breast mass.
  • Histological examination of the biopsy specimen showed bland multi-nucleated giant cells and mononuclear cells whose nuclei were morphologically similar.
  • CONCLUSION: The histological features of bland mononuclear and multinucleated giant cells along with the lack of any additional mesenchymal elements led to the diagnosis of giant cell tumor.
  • Resection of tumor was performed.
  • The patient is disease free as of the last follow-up visit.

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  • [Cites] Skeletal Radiol. 1992;21(7):482-8 [1439904.001]
  • [Cites] Respir Med. 1991 Sep;85(5):435-6 [1759012.001]
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  • (PMID = 20205847.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2825505
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42. Cavusoglu T, Senkoylu A, Ozsoy H, Dincel E: Multicentric, synchronous giant-cell tumor of bone. Saudi Med J; 2006 Apr;27(4):542-3
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  • [Title] Multicentric, synchronous giant-cell tumor of bone.
  • Multicentric giant cell tumor is a rare variant of giant cell tumor.
  • In this case, we report a case of a 15-year-old female patient with synchronous type of multicentric giant cell tumor.
  • [MeSH-major] Bone Neoplasms / pathology. Fibula. Giant Cell Tumor of Bone / pathology. Tibia

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  • (PMID = 16598336.001).
  • [ISSN] 0379-5284
  • [Journal-full-title] Saudi medical journal
  • [ISO-abbreviation] Saudi Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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43. Kai H, Wang X, Madhukar KS, Qin L, Yan Y, Zhang R, Wang X: Fabrication of a two-level tumor bone repair biomaterial based on a rapid prototyping technique. Biofabrication; 2009 Jun;1(2):025003
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  • [Title] Fabrication of a two-level tumor bone repair biomaterial based on a rapid prototyping technique.
  • After the removal of the giant cell tumor (GCT) of bone, it is necessary to fill the defects with adequate biomaterials.
  • A computer-assisted design model was used and the optimal fabrication parameters were determined through the manipulation of a pure PLGA/TCP system.
  • The results suggested that this unique composite porous scaffold material is a potential candidate for the repair of large bone defects after a surgical removal of GCT.
  • [MeSH-minor] Absorption. Bone Neoplasms / surgery. Bone Neoplasms / therapy. Calcium Phosphates / chemistry. Chitosan. Giant Cell Tumor of Bone / surgery. Giant Cell Tumor of Bone / therapy. Humans. Lactic Acid / chemistry. Microscopy, Electron, Scanning / methods. Polyglycolic Acid / chemistry. Porosity

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  • (PMID = 20811103.001).
  • [ISSN] 1758-5090
  • [Journal-full-title] Biofabrication
  • [ISO-abbreviation] Biofabrication
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Bone Substitutes; 0 / Calcium Phosphates; 0 / polylactic acid-polyglycolic acid copolymer; 26009-03-0 / Polyglycolic Acid; 33X04XA5AT / Lactic Acid; 9012-76-4 / Chitosan; 97Z1WI3NDX / calcium phosphate
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44. Protsenko VV: [Biocomposit--a new material for the bone restoration]. Klin Khir; 2006 Sep;(9):58-60
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  • The results of application in 15 patients of a new implantation material biocomposit for the bone defects substitution, which constituted the consequences of the giant-cell tumor extirpation, are adduced.

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  • (PMID = 17269396.001).
  • [ISSN] 0023-2130
  • [Journal-full-title] Klinichna khirurhiia
  • [ISO-abbreviation] Klin Khir
  • [Language] RUS
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / Bone Substitutes
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45. Imai K, Minamiya Y, Saito H, Kawai H, Ito M, Ogawa J: Giant cell tumor of the sternum. Jpn J Thorac Cardiovasc Surg; 2006 Sep;54(9):405-8
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  • [Title] Giant cell tumor of the sternum.
  • A primary giant cell tumor (GCT) originating from the sternum is extremely rare.
  • We report a case of a GCT originating from the sternum in a 45-year-old man who was referred to us for a mass in the anterior chest wall that had been growing slowly.
  • The tumor was 8.5 x 4.5 x 2.5cm, and the histopathological examination confirmed GCT.
  • Radical wide resection of primary sternum tumors and reconstruction with an appropriately rigid prosthetic material are necessary to minimize local recurrence.
  • [MeSH-major] Bone Neoplasms. Giant Cell Tumors. Sternum

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  • (PMID = 17037398.001).
  • [ISSN] 1344-4964
  • [Journal-full-title] The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi
  • [ISO-abbreviation] Jpn. J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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46. Kotnis NA, Davies AM, Kindblom LG, James SL: Giant cell tumour of the triquetrum. Skeletal Radiol; 2009 Jun;38(6):593-5
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  • [Title] Giant cell tumour of the triquetrum.
  • We present details of a case of giant cell tumour of bone (GCTOB) involving the triquetrum.
  • [MeSH-major] Bone Neoplasms / diagnosis. Carcinoma, Giant Cell / diagnosis. Carpal Bones / pathology. Carpal Bones / radiography. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 19294376.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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47. Slesarenko YA, Sampson SP, Gould ES: Giant cell tumour of the distal phalanx of the hand. Hand Surg; 2005;10(2-3):289-91
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  • [Title] Giant cell tumour of the distal phalanx of the hand.
  • Giant cell tumour of bone in the phalanx of the hand is extremely rare.
  • A case of giant cell tumour of distal phalanx treated with a ray amputation is presented.
  • [MeSH-major] Bone Neoplasms / surgery. Fingers. Giant Cell Tumor of Bone / surgery

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  • (PMID = 16568530.001).
  • [ISSN] 0218-8104
  • [Journal-full-title] Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
  • [ISO-abbreviation] Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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48. Gandhe A, Sankhe A, Aeron G, Joshi A: Epiphyseal giant cell tumour in an immature skeleton. Br J Radiol; 2008 Mar;81(963):e75-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epiphyseal giant cell tumour in an immature skeleton.
  • It is well known that giant cell tumours of the bone rarely occur below the age of 20 years.
  • Many radiologists and orthopaedicians do not even consider giant cell tumours as a differential diagnosis from a lytic lesion before epiphyseal closure.
  • This is a rare case report of a 14-year-old girl with proven giant cell tumour of the epiphysis of the distal femur.
  • [MeSH-major] Femoral Neoplasms / pathology. Femur / pathology. Giant Cell Tumor of Bone / pathology

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  • (PMID = 18270288.001).
  • [ISSN] 1748-880X
  • [Journal-full-title] The British journal of radiology
  • [ISO-abbreviation] Br J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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49. Gupta R, Mohindra S, Mahore A, Mathuriya SN, Radotra BD: Giant cell tumour of the clivus. Br J Neurosurg; 2008 Jun;22(3):447-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour of the clivus.
  • Primary giant cell tumours of the craniospinal axes are rare lesions.
  • In the present communication, we present malignant giant cell tumour of clivus, managed successfully with surgical decompression and adjuvant therapy.
  • [MeSH-major] Cranial Fossa, Posterior. Giant Cell Tumors / diagnosis. Skull Base Neoplasms / diagnosis

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  • (PMID = 18568739.001).
  • [ISSN] 0268-8697
  • [Journal-full-title] British journal of neurosurgery
  • [ISO-abbreviation] Br J Neurosurg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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50. Abate E, Banki F, Hagen JA, Klipfel N: Giant cell tumor of the sternum. Ann Thorac Surg; 2009 Aug;88(2):645-7
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  • [Title] Giant cell tumor of the sternum.
  • Primary giant cell tumors of the chest wall are extremely rare.
  • To date, we believe that there have been no reported cases of sternal giant cell tumors in the thoracic literature.
  • We report a case of an isolated giant cell tumor of the sternum in a 28-year-old man.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Sternum

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  • (PMID = 19632429.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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51. Faria RA, Silva CM, Miziara JE, Melo FY, Silva SR, Viana CR: Giant cell tumor of the sternum. J Bras Pneumol; 2010 Jul-Aug;36(4):517-20
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  • [Title] Giant cell tumor of the sternum.
  • We report the case of a 74-year-old female patient diagnosed with a giant cell tumor of the sternum.
  • The clinical and radiological presentation was indicative of a primary tumor of the sternum.
  • Commonly observed in the long bones of the appendicular skeleton, this type of tumor is characterized by its local aggressiveness and metastatic potential.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Sternum / pathology

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  • (PMID = 20835602.001).
  • [ISSN] 1806-3756
  • [Journal-full-title] Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
  • [ISO-abbreviation] J Bras Pneumol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Brazil
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52. Grabellus F, Sheu SY, Schmidt B, von Winterfeld F, Schoenfeld B, Taeger G, Hillen U, Schmid KW: [Giant cell tumors of soft tissue arising in surgical scars]. Pathologe; 2009 Sep;30(5):401-6
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  • [Title] [Giant cell tumors of soft tissue arising in surgical scars].
  • [Transliterated title] Riesenzelltumoren des Weichgewebes (mit niedrig-malignem Potenzial) in Operationsnarben.
  • Giant cell tumor of soft tissue (GCT-ST) is a rare primary soft tissue tumor with low malignant potential.
  • It is clinically and pathologically similar to the giant cell tumor of the bone.
  • Two cases of GCT-ST in surgical scars are reported.
  • Both tumors were initially regarded as tumor relapses of a leiomyosarcoma of deep soft tissue and a dermal in situ squamous cell carcinoma, respectively.
  • The development of GCT-ST in surgical scars has not been observed previously.
  • These findings suggest chronic inflammation and tissue repair as etiological factors in the development of GCT-ST.
  • The period of time between initial surgical intervention and the development of the GCT-ST seems to be unusually short for the development of a "true" second neoplasm, which may underline the sometimes diffuse border between reactive "pseudosarcomatous" and neoplastic fibro-histiocytic lesions.
  • [MeSH-major] Cicatrix / pathology. Giant Cell Tumors / pathology. Neoplasms, Second Primary / pathology. Postoperative Complications / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Carcinoma in Situ / pathology. Carcinoma in Situ / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Diagnosis, Differential. Facial Neoplasms / pathology. Facial Neoplasms / surgery. Groin / pathology. Groin / surgery. Humans. Leiomyosarcoma / pathology. Leiomyosarcoma / surgery. Male. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / surgery. Parotid Neoplasms / pathology. Parotid Neoplasms / secondary. Reoperation. Saphenous Vein / pathology. Saphenous Vein / surgery. Skin Neoplasms / pathology. Skin Neoplasms / surgery. Vascular Neoplasms / pathology. Vascular Neoplasms / surgery. Venous Thrombosis / pathology. Venous Thrombosis / surgery

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  • (PMID = 19367406.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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53. Karakida K, Ota Y, Aoki T, Akamatsu T, Kajiwara H, Hirabayashi K: Multiple giant cell tumors in maxilla and skull complicating Paget's disease of bone. Tokai J Exp Clin Med; 2010 Sep;35(3):112-7
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  • [Title] Multiple giant cell tumors in maxilla and skull complicating Paget's disease of bone.
  • Paget's disease of bone (PDB) is a very rare disease in the Asian countries including Japan, although as a bone metabolism disease it is relatively common in Europeans and Americans.
  • An infrequent complication of PDB is the giant cell tumor (GCT).
  • We encountered a case of GCT in the maxilla complicating PDB in a 57-year-old Japanese woman.
  • She developed her first GCT in the right occipital bone 14 years ago, which was resected.
  • Recently, she was found to have a GCT in the maxilla and maxillotomy was performed.
  • The sporadic form of GCT associated with PDB almost always arises in pagetic bone.
  • [MeSH-major] Giant Cell Tumor of Bone / complications. Maxillary Neoplasms / complications. Neoplasms, Multiple Primary / complications. Osteitis Deformans / complications. Skull Neoplasms / complications

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  • (PMID = 21319038.001).
  • [ISSN] 2185-2243
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
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54. Kamer S, Anacak Y, Savaş R, Doğanavşargil B, Haydaroğlu A: Giant cell tumor of the bone with an asymptomatic huge solitary lung metastasis; case presentation and literature review. J BUON; 2006 Jan-Mar;11(1):87-90
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  • [Title] Giant cell tumor of the bone with an asymptomatic huge solitary lung metastasis; case presentation and literature review.
  • A case concerning a man having giant cell tumor (GCT) of the leg and huge lung metastasis is presented.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary

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  • (PMID = 17318959.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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55. Mendenhall WM, Zlotecki RA, Scarborough MT, Gibbs CP, Mendenhall NP: Giant cell tumor of bone. Am J Clin Oncol; 2006 Feb;29(1):96-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of bone.
  • OBJECTIVE: To discuss the treatment and outcomes for giant cell tumor (GCT) of bone.
  • RESULTS: GCT is a rare benign bone lesion most often found in the extremities of women in the third and fourth decades of life.
  • Patients with extensive, recurrent, and/or biologically more aggressive tumors may require wide excision.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / surgery. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Curettage. Diagnosis, Differential. Humans. Neoplasm Staging. Prognosis. Radiotherapy, Adjuvant

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  • (PMID = 16462511.001).
  • [ISSN] 1537-453X
  • [Journal-full-title] American journal of clinical oncology
  • [ISO-abbreviation] Am. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 25
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56. Shrivastava S, Nawghare SP, Kolwadkar Y, Singh P: Giant cell tumour in the diaphysis of radius - a report. Cases J; 2008;1(1):106

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour in the diaphysis of radius - a report.
  • BACKGROUND: We present a case of a 35 yrs old female who presented with swelling over her forearm.
  • This is a rare case of a giant cell tumour in a nonepiphyseal region.
  • METHODS: Case report and presentation of clinical, radiological and histological data on single case of giant cell tumour of diaphysis of radius.
  • CONCLUSION: A thorough literature search and an exhaustive online search using various search engines revealed seven reported cases of giant cell tumours in the diaphysis of long bones.
  • We reiterate the fact that irrespective of the location, a giant cell tumour should be diagnosed based on its histology.

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  • (PMID = 18710556.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2531174
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57. Aksoy B, Ertürer E, Toker S, Seçkin F, Sener B: Tenosynovial giant cell tumour of the posterior cruciate ligament and its arthroscopic treatment. Singapore Med J; 2009 Jun;50(6):e204-5

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  • [Title] Tenosynovial giant cell tumour of the posterior cruciate ligament and its arthroscopic treatment.
  • Tenosynovial giant cell tumours originate from synovial tissues of the joints, tendon sheaths, mucosal bursas or fibrous tissues adjacent to tendons.
  • Tenosynovial giant cell tumours are rarely intra-articular.
  • We report a giant cell tumour of the tendon sheath arising from the posterior cruciate ligament diagnosed by magnetic resonance imaging and resected arthroscopically in a 54-year-old woman.
  • [MeSH-major] Arthroscopy / methods. Giant Cell Tumors / diagnosis. Giant Cell Tumors / surgery. Posterior Cruciate Ligament / pathology

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  • (PMID = 19551297.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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58. Lazaretti NS, Dallagasperina VW, Villaroel RU, Schlittler LA: [Giant cell tumour of distal femur with pulmonary metastases]. Rev Port Pneumol; 2010 Mar-Apr;16(2):331-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant cell tumour of distal femur with pulmonary metastases].
  • [Transliterated title] Tumor de células gigantes de fémur distal com metástases pulmonares.
  • Gian cell is normally a benign primary skeletal lesion located in the epiphysis of the long bones.
  • It is more frequente in the third and fourth decades of life but can exhibit the behaviour of a malignant tumour with distal metatasis.
  • The treatment of primary tumour is extensive surgical resection.
  • We report a case of a 35-year-old patient with lung metatases 21 months after curettage of giant cell tumour in distal femur.
  • [MeSH-major] Femoral Neoplasms / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary

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  • (PMID = 20437009.001).
  • [ISSN] 2172-6825
  • [Journal-full-title] Revista portuguesa de pneumologia
  • [ISO-abbreviation] Rev Port Pneumol
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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59. Minhas MS, Mehboob G, Ansari I: Giant cell tumours in hand bones. J Coll Physicians Surg Pak; 2010 Jul;20(7):460-3
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  • [Title] Giant cell tumours in hand bones.
  • OBJECTIVE: To describe the clinical features of Giant cell tumour of hand, in terms of aggressiveness, multicentricity and radiological grading at presentation, surgical procedures and final outcome.
  • METHODOLOGY: Seven cases of Giant cell tumour of hand bones were diagnosed in last 19 years and included in this study.
  • RESULTS: Two hundred ten cases of Giant cell tumour of bones were seen in last 19 years at JPMC, Karachi; 7 cases were of GCT of hand bones which constitutes around 3.3% of all GCT.
  • One case of multicentric lesion presented after treatment of primary GCT of distal radius.
  • Excision of the tumour and reconstruction by autogenous graft was performed in 6 cases and ray amputation in one case.
  • CONCLUSION: Giant cell tumour in hand bones is rare tumour and shows specific clinical and radiographic features with early involvement of entire bone, more aggressive behaviour and multi centricity.
  • The treatment of choice is resection of the tumour with reconstruction or ray amputation.Ansari.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Hand Bones

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  • (PMID = 20642946.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Pakistan
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60. Beaufour A, Cazals-Hatem D, Regimbeau JM, Ponsot P, Degott C, Belghiti J, Sauvanet A: [Osteoclastic giant cell tumour of the pancreas]. Gastroenterol Clin Biol; 2005 Feb;29(2):197-200
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  • [Title] [Osteoclastic giant cell tumour of the pancreas].
  • [Transliterated title] Tumeur à cellules géantes ostéoclastiques du pancréas.
  • Osteoclast giant cell tumours are bone tumours that occur in adults, and that are considered benign by WHO but locally aggressive.
  • Strictly identical tumours are described in the pancreas, without simultaneous bone localization.
  • We report the case of a 62-year woman with an osteoclast giant cell tumour of the distal pancreas, without any epithelial component, which was diagnosed after pancreatic resection and with no signs of recurrence after a 24-month follow-up.
  • These pancreatic tumours are rare, with a very poor prognosis, an unclear histogenesis; they are often confused with pleomorphic or undifferentiated pancreatic carcinomas including a component of osteoclast giant cell.
  • These osteoclast giant cell tumours of the pancreas usually present as large cystic tumours.
  • [MeSH-major] Giant Cell Tumor of Bone. Pancreatic Neoplasms

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  • (PMID = 15795672.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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61. Faisham WI, Zulmi W, Halim AS, Biswal BM, Mutum SS, Ezane AM: Aggressive giant cell tumour of bone. Singapore Med J; 2006 Aug;47(8):679-83
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  • [Title] Aggressive giant cell tumour of bone.
  • INTRODUCTION: The surgical treatment of Stage III or aggressive giant cell tumour of the bone, whether to perform intralesional or en-bloc resection, remains controversial.
  • The aim of this study is to identify the effectiveness of en-bloc resection for local control and final oncological outcome of the disease.
  • METHODS: The data of 20 consecutive patients with Stage III giant cell tumour were retrospectively reviewed to determine the local control and oncological outcome after treatment with wide resection.
  • Two patients with resectable disease were treated with thoracoscopic surgery and they remained disease-free 36 months after surgery.
  • Two patients with multiple lung metastases were treated with chemotherapy and the disease remained non-progressive.
  • The remaining two patients who refused chemotherapy showed radiological progression, and one succumbed to the disease with massive haemoptysis.
  • CONCLUSION: Aggressive giant cell tumour of bone should be treated with wide resection for better local control, and treatment of pulmonary metastases is mandatory for overall prognosis.
  • [MeSH-major] Bone Neoplasms / surgery. Carcinoma, Giant Cell / surgery. Treatment Outcome
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies

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  • (PMID = 16865207.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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62. Muramatsu K, Mine T, Ichihara K: Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. J Am Podiatr Med Assoc; 2006 Jul-Aug;96(4):359-61

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  • [Title] Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon.
  • We present a case of atypical giant cell tumor of the tendon sheath originating from the extensor hallucis longus tendon.
  • The tumor contained multiple nodules and overlay the tendon 16 cm.
  • Magnetic resonance imaging was the most useful preoperative investigation and showed the characteristic appearance of giant cell tumor of the tendon sheath, thus allowing local excision to be planned and executed.
  • We discuss how local recurrence of this tumor could be prevented.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Giant Cell Tumors / surgery. Synovial Membrane. Tendons. Tenosynovitis / diagnosis

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  • (PMID = 16868332.001).
  • [ISSN] 8750-7315
  • [Journal-full-title] Journal of the American Podiatric Medical Association
  • [ISO-abbreviation] J Am Podiatr Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Onishi H, Kaya M, Wada T, Nagoya S, Sasaki M, Yamashita T: Giant cell tumor of the sacrum treated with selective arterial embolization. Int J Clin Oncol; 2010 Aug;15(4):416-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the sacrum treated with selective arterial embolization.
  • Giant cell tumor of the sacrum is extremely difficult to manage.
  • In this manuscript, we report an early clinical result of a case of giant cell tumor of the sacrum successfully managed with selective arterial embolization.
  • A 56-year-old woman underwent selective embolization for management of giant cell tumor of the sacrum.
  • We stress the effectiveness of selective arterial embolization as a less invasive and less complicated primary treatment of giant cell tumors of the sacrum.
  • [MeSH-major] Embolization, Therapeutic. Femoral Artery. Giant Cell Tumor of Bone / therapy. Sacrum. Spinal Neoplasms / therapy

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  • (PMID = 20198397.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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64. Pelaz AC, Llorente Pendás JL, Rodrigo Tapia JP, Suárez Nieto C: Giant cell tumor of the greater wing of the sphenoid: an unusual presentation. J Craniofac Surg; 2008 May;19(3):822-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the greater wing of the sphenoid: an unusual presentation.
  • We report a very unusual presentation of giant cell tumor probably originated on the greater wing of the sphenoid and show a review about the knowledge and the treatment of the lesion in this rare localization.
  • We treated a 48-year-old man with a giant cell tumor of the infratemporal fossa.
  • The tumor was resected by means of a subtemporal-preauricular approach, and after 12 months of follow-up, the patient is free of recurrence.
  • Giant cell tumors of the skull base are an extremely rare neoplasm, and there is not much information on the literature about the treatment and the prognostic.
  • [MeSH-major] Craniotomy / methods. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery. Skull Base Neoplasms / pathology. Skull Base Neoplasms / surgery

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  • (PMID = 18520407.001).
  • [ISSN] 1049-2275
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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65. Purohit S, Pardiwala DN: Imaging of giant cell tumor of bone. Indian J Orthop; 2007 Apr;41(2):91-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of giant cell tumor of bone.
  • Giant cell tumor (GCT) of bone is a benign but locally aggressive and destructive lesion generally occurring in skeletally mature individuals.
  • On radiographs, GCT demonstrates a lytic lesion centered in the epiphysis but involving the metaphysis and extending at least in part to the adjacent articular cortex.
  • There is no mineralized tumor matrix.
  • Giant cell tumor can produce wide-ranging appearances depending on site, complications such as hemorrhage or pathological fracture and after surgical intervention.
  • This review demonstrates a spectrum of these features and describes the imaging characteristics of GCT in conventional radiographs, computerized tomography scans, magnetic resonance imaging, bone scans, positron emission tomography scans and angiography.

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  • (PMID = 21139758.001).
  • [ISSN] 0019-5413
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2989147
  • [Keywords] NOTNLM ; Giant cell tumor / imaging / magnetic resonance imaging
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66. Machinami R, Nishida K, Ishida T, Matsumoto S, Kuroda K, Kobayashi M, Takeuchi K, Ishikawa Y: Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur. Pathol Res Pract; 2008;204(8):583-8
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  • [Title] Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur.
  • We report a new type of secondary malignant giant cell tumor of bone, the malignancy of which was assigned to a carcinosarcoma, i.e., osteosarcoma and squamous cell carcinoma.
  • It occurred 25 years after curettage and bone graft surgery under the diagnosis of giant cell tumor of the right distal femur.
  • Although secondary malignant giant cell tumor is known as a sarcoma arising at the site of a previously diagnosed giant cell tumor, this case should be regarded as a new type of secondary malignant giant cell tumor of bone.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinosarcoma / pathology. Femoral Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Neoplasm Recurrence, Local. Osteosarcoma / pathology

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  • (PMID = 18440162.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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67. Tejera-Vaquerizo A, Ruiz-Molina I, González-Serrano T, Solís-García E: Primary giant cell tumor of soft tissue in the finger. Dermatol Online J; 2008;14(6):7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary giant cell tumor of soft tissue in the finger.
  • Primary giant cell tumor of soft tissue (GCTST) arising in a finger is a rare event.
  • We report a case of a 54-year-old man with a primary finger giant cell tumor that appeared histologically identical to giant cell tumor of bone.
  • The distinction of this entity from other more common primary finger tumors with giant cell morphology is emphasized.
  • [MeSH-major] Fingers / pathology. Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18713588.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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68. Ryś J, Kruczak A, Marczyk E, Skotnicki P, Moskal J, Ambicka A, Harazin-Lechowska A, Wasilewska A, Vogelgesang M, Dyczek S: Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis. Pol J Pathol; 2009;60(2):98-104; quiz 105
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  • [Title] Primary soft tissue giant cell tumour of the neck. Cytological and histological characteristics of the tumour and differential diagnosis.
  • Giant cell tumour of soft part is a very rare neoplasm.
  • The majority of these tumours are located superficially (in subcutaneous tissue) and occur in the proximal parts of the extremities.
  • The deep-situated giant cell tumours of the neck are extremely rare.
  • That is why we report a case of primary giant cell tumour of soft part localized in the trapezius muscle of a 19-year-old woman.
  • We present both cytological and histological picture of the neoplasm.
  • [MeSH-major] Giant Cell Tumors / pathology. Head and Neck Neoplasms / pathology. Muscle, Skeletal / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Diagnosis, Differential. Female. Histiocytoma, Benign Fibrous / diagnosis. Humans. Osteosarcoma / diagnosis. Sarcoma, Synovial / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Treatment Outcome. Young Adult

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  • (PMID = 19886185.001).
  • [ISSN] 1233-9687
  • [Journal-full-title] Polish journal of pathology : official journal of the Polish Society of Pathologists
  • [ISO-abbreviation] Pol J Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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69. Singh PJ, Constable L, O'Donnell J: Arthroscopic excision of a giant-cell tumour of the ligamentum teres. J Bone Joint Surg Br; 2009 Jun;91(6):809-11

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Arthroscopic excision of a giant-cell tumour of the ligamentum teres.
  • Primary giant-cell tumour of soft tissue arising in the ligamentum teres has not been previously described.
  • We report a case of such a tumour in a 46-year-old woman.
  • [MeSH-major] Giant Cell Tumors / surgery. Hip Joint. Ligaments, Articular / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 19483237.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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70. May SA, Deavers MT, Resetkova E, Johnson D, Albarracin CT: Giant cell tumor of soft tissue arising in breast. Ann Diagn Pathol; 2007 Oct;11(5):345-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of soft tissue arising in breast.
  • Primary giant cell tumor of soft tissue (GCT-ST) arising in breast is exceedingly rare.
  • We report a case of a 60-year-old woman with a primary breast giant cell tumor that appeared histologically identical to giant cell tumor of bone and had a clinically malignant course.
  • Histopathological evaluation revealed a neoplasm composed of mononuclear cells admixed with osteoclast-like giant cells resembling giant cell tumor of bone.
  • These features were most consistent with GCT-ST, an uncommon neoplasm of low malignant potential.
  • This case demonstrates the difficulty of predicting clinical behavior of GCT-ST of breast on the basis of histological features and depth of tumor alone.
  • To our knowledge, this is the first case report of a GCT-ST arising in the breast associated with a fatal outcome.
  • The distinction of this entity from other more common primary breast tumors with giant cell morphology is also emphasized.
  • [MeSH-major] Breast Neoplasms / pathology. Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 17870021.001).
  • [ISSN] 1092-9134
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / Antigens, Differentiation, Myelomonocytic; 0 / CD68 antigen, human; 0 / Vimentin
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71. Dickson BC, Li SQ, Wunder JS, Ferguson PC, Eslami B, Werier JA, Turcotte RE, Kandel RA: Giant cell tumor of bone express p63. Mod Pathol; 2008 Apr;21(4):369-75
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  • [Title] Giant cell tumor of bone express p63.
  • p63 contributes to skeletal development and tumor formation; however, little is known regarding its activity in the context of bone and soft tissue neoplasms.
  • The purpose of this study was to investigate p63 expression in giant cell tumor of bone and to determine whether it can be used to discriminate between other giant cell-rich tumors.
  • Seventeen cases of giant cell tumor of bone were examined to determine the cell type expressing p63 and identify the isoforms present.
  • Total RNA or cell protein was extracted from mononuclear- or giant cell-enriched fractions or intact giant cell tumor of bone and examined by RT-PCR or western blot, respectively.
  • Immunohistochemistry was used to evaluate p63 expression in paraffin embedded sections of giant cell tumor of bone and in tumors containing multinucleated giant cells, including: giant cell tumor of tendon sheath, pigmented villonodular synovitis, aneurysmal bone cyst, chondroblastoma, and central giant cell granuloma.
  • The mononuclear cell component in all cases of giant cell tumor of bone was found to express all forms of TAp63 (alpha, beta, and gamma), whereas only low levels of the TAp63 alpha and beta isoforms were detected in multinucleated cells; DeltaNp63 was not detected in these tumors.
  • Western blot analysis identified p63 protein as being predominately localized to mononuclear cells compared to giant cells.
  • This was confirmed by immunohistochemical staining of paraffin-embedded tumor sections, with expression identified in all cases of giant cell tumor of bone.
  • Only a proportion of cases of aneurysmal bone cyst and chondroblastoma showed p63 immunoreactivity whereas it was not detected in central giant cell granuloma, giant cell tumor of tendon sheath, or pigmented villonodular synovitis.
  • The differential expression of p63 in giant cell tumor of bone and central giant cell granuloma suggest that these two tumors may have a different pathogenesis.
  • Moreover, p63 may be a useful biomarker to differentiate giant cell tumor of bone from central giant cell granuloma and other giant cell-rich tumors, such as giant cell tumor of tendon sheath and pigmented villonodular synovitis.
  • [MeSH-major] Biomarkers, Tumor / analysis. Bone Neoplasms / metabolism. Giant Cell Tumor of Bone / metabolism. Membrane Proteins / biosynthesis
  • [MeSH-minor] Blotting, Western. Diagnosis, Differential. Gene Expression. Giant Cell Tumors / pathology. Granuloma, Giant Cell / pathology. Humans. Immunohistochemistry. Protein Isoforms / biosynthesis. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 18311114.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / Protein Isoforms
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72. Minhas MS, Mehboob G: Giant cell tumour of the proximal ulna. J Coll Physicians Surg Pak; 2010 Jun;20(6):416-8
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  • [Title] Giant cell tumour of the proximal ulna.
  • The report describes a rare case of giant cell tumour of proximal end of ulna occurring in 22 years old lady.
  • The tumour was excised en-bloc; reconstruction by fibular graft and fusion of elbow in functional position was performed.
  • Patient is tumour-free and having stable elbow after 5 years of resection and reconstruction.
  • [MeSH-major] Bone Neoplasms / surgery. Giant Cell Tumor of Bone / surgery. Ulna

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  • (PMID = 20642977.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Pakistan
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73. Walsh EF, Mechrefe A, Akelman E, Schiller AL: Giant cell tumor of tendon sheath. Am J Orthop (Belle Mead NJ); 2005 Mar;34(3):116-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of tendon sheath.
  • Giant cell tumor of tendon sheath (GCTTS) is the most common primary tumor of the hand.
  • Many different theories have recently been proposed as to whether GCTTS is a neoplasm or a localized reactive process.
  • [MeSH-major] Giant Cell Tumors / pathology. Hand. Soft Tissue Neoplasms / pathology. Tendons

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  • (PMID = 15828513.001).
  • [ISSN] 1078-4519
  • [Journal-full-title] American journal of orthopedics (Belle Mead, N.J.)
  • [ISO-abbreviation] Am J. Orthop.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 18
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74. Morii T, Yabe H, Morioka H, Suzuki Y, Anazawa U, Toyama Y: Curettage and allograft reconstruction for giant cell tumours. J Orthop Surg (Hong Kong); 2008 Apr;16(1):75-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Curettage and allograft reconstruction for giant cell tumours.
  • PURPOSE: To evaluate treatment outcomes in patients with giant cell tumours after curettage and allograft reconstruction and to identify the risk factors for poor oncological and functional outcome.
  • METHODS: 29 patients with giant cell tumours of bone who underwent curettage and allograft reconstruction were retrospectively reviewed.
  • In 7 patients the tumours recurred (6 within 2 years); the 5-year recurrence-free survival rate was 77%.
  • Tumour in the distal femur was a risk factor for postoperative fracture (p=0.02).
  • We recommend the use of adjuvants and allografts for the management of giant cell tumours.
  • [MeSH-major] Bone Neoplasms / surgery. Bone Transplantation. Curettage. Giant Cell Tumor of Bone / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Orthopedic Procedures. Postoperative Complications. Wound Healing

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  • (PMID = 18453664.001).
  • [ISSN] 1022-5536
  • [Journal-full-title] Journal of orthopaedic surgery (Hong Kong)
  • [ISO-abbreviation] J Orthop Surg (Hong Kong)
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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75. Puri A, Agarwal M: Treatment of giant cell tumor of bone: Current concepts. Indian J Orthop; 2007 Apr;41(2):101-8

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  • [Title] Treatment of giant cell tumor of bone: Current concepts.
  • Giant cell tumor (GCT) of bone though one of the commonest bone tumors encountered by an orthopedic surgeon continues to intrigue treating surgeons.
  • The surgeon needs to strike a balance during treatment between reducing the incidence of local recurrence while preserving maximal function.Differing opinions pertaining to the use of adjuvants for extension of curettage, the relative role of bone graft or cement to pack the defect and the management of recurrent lesions are some of the issues that offer topics for eternal debate.Current literature suggests that intralesional curettage strikes the best balance between controlling disease and preserving optimum function in the majority of the cases though there may be occasions where the extent of the disease mandates resection to ensure adequate disease clearance.An accompanying treatment algorithm helps outline the management strategy in GCT.

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  • (PMID = 21139760.001).
  • [ISSN] 0019-5413
  • [Journal-full-title] Indian journal of orthopaedics
  • [ISO-abbreviation] Indian J Orthop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2989131
  • [Keywords] NOTNLM ; Curettage / giant cell tumor / treatment
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76. Moskovszky L, Dezsö K, Athanasou N, Szendröi M, Kopper L, Kliskey K, Picci P, Sápi Z: Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability. Mod Pathol; 2010 Mar;23(3):359-66
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability.
  • Giant cell tumour of bone, a benign but potentially aggressive neoplasm, shows an increasing rate of chromosomal aneusomy that correlates with clinical course.
  • Mechanisms that generate chromosomal instability in giant cell tumour of bone are poorly understood.
  • Centrosome alteration is a common phenomenon in many cancers and has a major role in the development of chromosomal instability in cancer cells.
  • To gain an insight into the possible mechanism for the generation of chromosomal instability in giant cell tumour of bone, we analysed 100 cases, including 57 primary nonrecurrent, 35 recurrent and 8 malignant giant cell tumour of bone cases. gamma-Tubulin immunohistochemistry was performed on tissue microarrays of 59 formalin-fixed paraffin-embedded cases, whereas pericentrin and gamma-tubulin fluorescent immunocytochemistry was carried out on 41 frozen smears.
  • Centrosome amplification was significantly higher in recurrent and malignant giant cell tumour of bones compared with nonrecurrent tumours (P<0.001).
  • A comparison of the percentage of aneusomic cells with a normal centrosome content (4.7%) with that of aneusomic cells with centrosome amplification (6.4%) revealed no significant association between chromosome number alterations and centrosome aberrations (P=0.31).
  • These findings indicate that centrosome alteration and frequency of aneusomy correlate with clinical behaviour; the lack of an association between centrosome amplification and chromosome number alteration suggests that alternative causative mechanisms produce genetic instability in giant cell tumour of bone.
  • [MeSH-major] Bone Neoplasms / genetics. Centrosome / pathology. Chromosomal Instability. Giant Cell Tumor of Bone / genetics

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  • (PMID = 20062006.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens; 0 / Tubulin; 0 / pericentrin
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77. Lüthje P, Nurmi-Lüthje I: Tenosynovial juxta-articular giant-cell tumour of the knee--an unusual location of the tumour. Acta Orthop Belg; 2006 Dec;72(6):772-4

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tenosynovial juxta-articular giant-cell tumour of the knee--an unusual location of the tumour.
  • We present a case of a physically active 46 year-old woman who was treated operatively for a juxta-articular tenosynovial giant cell tumour of the knee that caused mechanical symptoms.
  • The tumour was located in the infrapatellar fat pad.
  • [MeSH-major] Giant Cell Tumors / pathology. Patellar Ligament. Synovial Membrane / pathology

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  • (PMID = 17260619.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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78. Mitsionis G, Pakos EE, Gavriilidis I, Batistatou A: Cubital tunnel syndrome due to giant cell tumour of tendon sheaths. Hand Surg; 2006;11(1-2):89-91

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cubital tunnel syndrome due to giant cell tumour of tendon sheaths.
  • In the present report we describe the first case of cubital tunnel syndrome due to giant cell tumour of the tendon sheaths.
  • [MeSH-major] Cubital Tunnel Syndrome / etiology. Elbow. Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology. Tendons

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  • (PMID = 17080537.001).
  • [ISSN] 0218-8104
  • [Journal-full-title] Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
  • [ISO-abbreviation] Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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79. Abdel-Motaal MM, Othman AS, Katchy MK, Jassar AK: Soft-tissue recurrence of giant cell tumor of bone associated with pulmonary metastases. Gulf J Oncolog; 2009 Jan;(5):49-53
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  • [Title] Soft-tissue recurrence of giant cell tumor of bone associated with pulmonary metastases.
  • A soft tissue recurrence associated with pulmonary metastases developed in a 46 year old lady one year after intra-lesional excision and autogenous bone graft of giant cell tumor of bone of the distal end of the right radius.
  • Brief review of relevant literatures addressed different factors that influence addressed different factors that influence recurrence, treatment Options of primary and recurrent GCT of distal radius, and metaplastic recurrent GCT of distal radius, and metaplastic bone formation in such lesions.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / secondary. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / pathology. Radius / pathology

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  • (PMID = 20084786.001).
  • [ISSN] 2078-2101
  • [Journal-full-title] The Gulf journal of oncology
  • [ISO-abbreviation] Gulf J Oncolog
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Kuwait
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80. Ech-Charif S, Aubert S, Buob D, Verhulst P, Blomme V, Migaud H, Leroy X: [Giant cell tumor of soft tissues. Report of two cases]. Ann Pathol; 2006 Feb;26(1):26-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Giant cell tumor of soft tissues. Report of two cases].
  • [Transliterated title] Tumeur à cellules géantes des tissus mous.
  • We report two cases of giant-cell tumour of soft tissue (TCG-TM).
  • The first case occurred in a 26-year-old woman presenting with a subcutaneous tumour of the left leg.
  • Pathological study revealed a tumour comparable to benign giant cell tumour of bone.
  • Microscopically, the tumour was composed of sheets of mononuclear and multinucleated cells.
  • Mononuclear cells presented severe atypia and a high mitotic activity.
  • TCG-TMs are uncommon and represent a distinct entity whose clinical behaviour and histological features are similar to giant-cell tumour of bone.
  • The differential diagnosis includes other tumours rich in osteoclast-like cells.
  • [MeSH-major] Giant Cell Tumors / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Bone Neoplasms / pathology. Female. Giant Cells / pathology. Humans. Leukocytes, Mononuclear / pathology. Male. Middle Aged

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  • (PMID = 16841007.001).
  • [ISSN] 0242-6498
  • [Journal-full-title] Annales de pathologie
  • [ISO-abbreviation] Ann Pathol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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81. Notarianni C, Abreo F, Nanda A: Cranial vault metastasis of giant cell tumor. Ann Diagn Pathol; 2008 Aug;12(4):286-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cranial vault metastasis of giant cell tumor.
  • Giant cell tumors are benign bony tumors involving the epiphysis of long bones.
  • Here, we present a case of giant cell tumor involving the parietal bone that had metastasized from the sacrum.
  • Newer radiation treatments seem to be a promising favorable adjunct to wide local resection and should be investigated further for these tumors.
  • [MeSH-major] Giant Cell Tumor of Bone / pathology. Parietal Bone / pathology. Sacrum / pathology. Skull Neoplasms / secondary. Spinal Neoplasms / pathology

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  • (PMID = 18620997.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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82. Gupta R, Jambhekar N, Sanghvi D: Giant-cell tumour of the synovium in a facet joint in the thoracic spine of a child. J Bone Joint Surg Br; 2008 Feb;90(2):236-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant-cell tumour of the synovium in a facet joint in the thoracic spine of a child.
  • Giant-cell tumour of the synovium is known to affect the fingers or toes of adults.
  • The lesions of giant-cell tumour of the synovium have a classical radiological appearance, but require a high index of suspicion for correct recognition.
  • Unlike giant-cell tumour of the synovium at other well-known sites, spinal lesions lack the characteristic papillary architecture, thereby raising other diagnostic possibilities.
  • We describe a giant-cell tumour of the synovium of the left facet joint of a thoracic vertebra in a nine-year-old girl.
  • The tumour was treated successfully by surgical excision.
  • [MeSH-major] Giant Cell Tumors / radiography. Spinal Neoplasms / radiography. Synovial Membrane / radiography. Thoracic Vertebrae / surgery. Zygapophyseal Joint

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  • (PMID = 18256096.001).
  • [ISSN] 0301-620X
  • [Journal-full-title] The Journal of bone and joint surgery. British volume
  • [ISO-abbreviation] J Bone Joint Surg Br
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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83. Liu B, Yu SF, Wu YT, Pang SZ: [Central giant cell lesions of the jaws: a clinicopathological study of 31 cases]. Zhonghua Kou Qiang Yi Xue Za Zhi; 2005 Jan;40(1):67-9
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  • [Title] [Central giant cell lesions of the jaws: a clinicopathological study of 31 cases].
  • OBJECTIVE: To study the clinicopathologic features of central giant cell granuloma (CGCG) of the jaws and the relationship between the pathologic features and its clinical behavior.
  • METHODS: Histologic, radiographic and follow-up information for 31 cases of central giant cell granuloma were reviewed.
  • RESULTS: The majority of the giant cell granuloma of the jaws occurred in patients under 30 with a predilection of females and mostly were involved in the mandible.
  • The multinucleated giant cell scattered unevenly, the numbers of the nuclei were few and mostly 10-19.
  • CONCLUSIONS: CGCG was a non-neoplastic lesion of the jaws which was different from the giant cell tumor.
  • It was difficult to distinguish between the CGCG and giant cell tumor (GCT), and to predict its clinical behavior only by the histopathological patterns.
  • [MeSH-major] Granuloma, Giant Cell / pathology. Jaw Diseases / pathology

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  • (PMID = 15774157.001).
  • [ISSN] 1002-0098
  • [Journal-full-title] Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
  • [ISO-abbreviation] Zhonghua Kou Qiang Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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84. Vasconez HC, Nisanci M, Lee EY: Giant cell tumour of the flexor tendon sheath of the foot. J Plast Reconstr Aesthet Surg; 2008 Jul;61(7):815-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour of the flexor tendon sheath of the foot.
  • Giant cell tumour of tendon sheath (GCTTS) is a benign, soft-tissue tumour arising from synovial cells of tendon sheaths.
  • Interpretation of the magnetic resonance imaging failed to include giant cell tumours in the preoperative differential diagnosis.
  • Considering the proximity of the tumour to important anatomic structures, less radical but grossly complete excision was employed, followed by appropriate periodic re-evaluation.
  • Our case presents an unusual occurrence of this tumour with medial localisation of the lesion in the foot, extending through the tarsal tunnel.
  • [MeSH-major] Foot. Giant Cell Tumors / surgery. Soft Tissue Neoplasms / surgery. Tendons

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  • (PMID = 17512270.001).
  • [ISSN] 1878-0539
  • [Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS
  • [ISO-abbreviation] J Plast Reconstr Aesthet Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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85. Kakarala G, Peddu P, Lahoti O: Localized pigmented villonodular synovitis: arthroscopic treatment of a lesion arising from the quadriceps tendon sheath. Arthroscopy; 2007 Apr;23(4):448.e1-3
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  • [Title] Localized pigmented villonodular synovitis: arthroscopic treatment of a lesion arising from the quadriceps tendon sheath.
  • Localized PVNS, also known as giant cell tumor of the tendon sheath, is even more uncommon.

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  • (PMID = 17418347.001).
  • [ISSN] 1526-3231
  • [Journal-full-title] Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
  • [ISO-abbreviation] Arthroscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Hulse N, Watson SJ: Giant cell tumour of tendon sheath in a child: a case report. Hand Surg; 2005 Jul;10(1):97-100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour of tendon sheath in a child: a case report.
  • Giant cell tumour of the tendon sheath is uncommon in children.
  • We describe this tumour arising from the right ring finger in an eight-year-old girl.
  • The tumour was treated by surgical excision with good outcome.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Soft Tissue Neoplasms / diagnosis. Tendons / surgery

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  • (PMID = 16106509.001).
  • [ISSN] 0218-8104
  • [Journal-full-title] Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand
  • [ISO-abbreviation] Hand Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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87. Fang X, Hicks DG, Hicks W Jr, Zhang S: Osteoclastlike giant cell tumor of the salivary gland. Ann Diagn Pathol; 2009 Apr;13(2):114-8
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  • [Title] Osteoclastlike giant cell tumor of the salivary gland.
  • Giant cell tumor of the salivary gland is extremely rare, with only 15 cases published in the English literature.
  • The tumor characteristically contains a mixture of multinucleated giant cells, resembling osteoclasts of bone, and neoplastic mononuclear cells.
  • We are reporting an additional case of giant cell tumor of the parotid gland that was initially misinterpreted as an extraosseous osteosarcoma in the biopsy specimen.
  • The histologic and immunohistochemical findings as well as a review of the literature with discussion of the histogenesis of this unusual neoplasm are presented.
  • [MeSH-major] Giant Cell Tumors / pathology. Osteoclasts / pathology. Parotid Neoplasms / pathology

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  • (PMID = 19302960.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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88. Sunil Kumar Y, Raghupathi AR, Chidananda: Giant cell tumor of skin. Indian J Dermatol Venereol Leprol; 2006 Mar-Apr;72(2):145-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of skin.
  • Giant cell tumor of the skin is a rare entity showing gross and histological features similar to those of giant cell tumor of the bone.
  • We report a case of malignant giant cell tumor of the thigh in a 55-year-old man.
  • Histological features showed a biphasic population of mononuclear cells admixed with osteoclast-like giant cells.
  • The nuclei of the giant cells were similar to those of the mononuclear cells.
  • This tumor should be distinguished from a variety of cutaneous neoplasms that contain multinucleated giant cells.
  • [MeSH-major] Giant Cell Tumors / pathology. Skin Neoplasms / pathology

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  • (PMID = 16707824.001).
  • [ISSN] 0378-6323
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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89. Deheshi BM, Jaffer SN, Griffin AM, Ferguson PC, Bell RS, Wunder JS: Joint salvage for pathologic fracture of giant cell tumor of the lower extremity. Clin Orthop Relat Res; 2007 Jun;459:96-104
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  • [Title] Joint salvage for pathologic fracture of giant cell tumor of the lower extremity.
  • Pathologic fracture through giant cell tumor is thought to be associated with higher rates of recurrence and poor functional outcome.
  • We compared patients with and without pathologic fracture through giant cell tumor of weightbearing long bones.
  • We retrospectively reviewed 139 patients with giant cell tumor of weightbearing long bones with (n = 43) and without (n = 96) pathologic fracture at presentation; the two groups had similar demographics.
  • Joint salvage for patients with pathologic fractures through giant cell tumor of weightbearing bones is a reasonable option with functional outcomes and recurrence rates comparable to those of patients without fracture.
  • [MeSH-major] Bone Neoplasms / pathology. Bone Neoplasms / surgery. Femoral Fractures / surgery. Giant Cell Tumor of Bone / pathology. Giant Cell Tumor of Bone / surgery. Limb Salvage. Tibial Fractures / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Treatment Outcome

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  • (PMID = 17417093.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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90. Ghert M, Simunovic N, Cowan RW, Colterjohn N, Singh G: Properties of the stromal cell in giant cell tumor of bone. Clin Orthop Relat Res; 2007 Jun;459:8-13
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  • [Title] Properties of the stromal cell in giant cell tumor of bone.
  • The histiogenesis and mechanisms of bone destruction in giant cell tumor (GCT) of bone are not well understood.
  • We asked whether the spindle-like stromal cells of GCT of bone exhibit osteoblastic properties, and whether the stromal cells produce active matrix-degrading proteases in vitro.
  • We performed immunohistochemistry on 17 paraffin-embedded archival specimens with a pathologic diagnosis of GCT with monoclonal antibodies for the osteoblastic lineage markers osteopontin, osteonectin, and osteocalcin.
  • Primary cell cultures of GCT stromal cells were prepared from two fresh tumor specimens.
  • Western blots were used on the cell lysates and media to detect osteocalcin precursor and the matrix-degrading proteases MMP-2 and MMP-9.
  • We found the stromal cells in culture produce osteocalcin precursor, indicating osteoblastic lineage.
  • The cells also express both the active and inactive isoforms of MMP-2 and MMP-9.
  • The spindle like stromal cells of GCT have characteristics of osteoblast progenitors and produce active matrix-degrading proteases.
  • These cells may therefore play a central role in bone destruction.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Stromal Cells / physiology
  • [MeSH-minor] Adult. Cell Culture Techniques. Female. Humans. Male. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Middle Aged. Osteoblasts / physiology. Osteocalcin / metabolism. Osteonectin / metabolism. Osteopontin / metabolism

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  • (PMID = 17327805.001).
  • [ISSN] 0009-921X
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Osteonectin; 104982-03-8 / Osteocalcin; 106441-73-0 / Osteopontin; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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91. Economopoulos K, Barker L, Beauchamp C, Claridge R: Case report: reconstruction of the distal tibia with porous tantalum spacer after resection for giant cell tumor. Clin Orthop Relat Res; 2010 Jun;468(6):1697-701
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  • [Title] Case report: reconstruction of the distal tibia with porous tantalum spacer after resection for giant cell tumor.
  • Treatment options for giant cell tumors of the distal tibia include curettage and cement packing, curettage and bone grafting, or resection and reconstruction for aggressive tumors.
  • Curettage of aggressive tumors often leads to severe bone loss requiring reconstruction.
  • We present a case of giant cell tumor of the distal tibia treated with curettage and arthrodesis using a porous tantalum spacer.
  • Complete removal of the tumor and successful arthrodesis of the ankle were accomplished using the spacer.
  • The patient returned to pain-free walking along with eradication of the giant cell tumor.
  • We believe porous tantalum spacers are a reasonable option for reconstructing the distal tibia after curettage of a giant cell tumor with extensive bone loss.
  • [MeSH-major] Ankle Joint / surgery. Arthrodesis / instrumentation. Bone Neoplasms / surgery. Curettage. Giant Cell Tumor of Bone / surgery. Orthopedic Equipment. Tantalum. Tibia / surgery

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  • (PMID = 19756900.001).
  • [ISSN] 1528-1132
  • [Journal-full-title] Clinical orthopaedics and related research
  • [ISO-abbreviation] Clin. Orthop. Relat. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 6424HBN274 / Tantalum
  • [Other-IDs] NLM/ PMC2865625
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92. Kotwal PP, Nagaraj C, Gupta V: Vascularised joint transfer in the management of recurrent giant cell tumour of the second metacarpal. J Hand Surg Eur Vol; 2008 Jun;33(3):314-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Vascularised joint transfer in the management of recurrent giant cell tumour of the second metacarpal.
  • This paper presents the medium-term follow-up results (34 and 40 months, respectively) of two cases of recurrent giant cell tumour of the head of the second metacarpal, treated by marginal excision and reconstruction with a vascularised toe joint transfer.
  • Both patients had painless, stable joints with excellent ranges of motion at the metacarpophalangeal joint of 80 degrees and 70 degrees , respectively, no degenerative changes and no recurrence of the tumours.
  • [MeSH-major] Bone Neoplasms / surgery. Finger Joint / surgery. Giant Cell Tumor of Bone / surgery. Metacarpal Bones. Neoplasm Recurrence, Local / surgery. Toe Joint / transplantation

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  • (PMID = 18562363.001).
  • [ISSN] 1753-1934
  • [Journal-full-title] The Journal of hand surgery, European volume
  • [ISO-abbreviation] J Hand Surg Eur Vol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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93. Kumar A, Varshney MK, Trikha V, Rastogi S: An unusual presentation of a rare chest wall tumour: giant cell tumour of bone. Joint Bone Spine; 2007 Jan;74(1):100-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An unusual presentation of a rare chest wall tumour: giant cell tumour of bone.
  • Giant cell tumour of bone is an aggressive benign bone tumour.
  • We report a case of giant cell tumour of the anterior end of the rib masquerading as a sub-mammary abscess in lactating women.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Thoracic Wall

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  • (PMID = 17197221.001).
  • [ISSN] 1778-7254
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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94. El Demellawy D, Saleh R, Daya D, Alowami S: Malignant giant cell tumor of the vulva. Int J Gynecol Pathol; 2010 Jan;29(1):93-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant giant cell tumor of the vulva.
  • Giant cell malignant fibrous histiocytoma or giant cell tumor of the soft parts (GCTSP) is a rare soft tissue tumor.
  • GCTSP has an unpredictable behavior; the majority of the reported cases showed benign histology and those that showed malignant morphologic features were extremely rare.
  • Histologic features and the immunoprofile of the tumor and differential diagnosis are discussed in detail.
  • [MeSH-major] Giant Cell Tumors / secondary. Neoplasm Recurrence, Local / pathology. Vulvar Neoplasms / pathology

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  • (PMID = 19952930.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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95. Wan JM, Magarelli N, Peh WC, Guglielmi G, Shek TW: Imaging of giant cell tumour of the tendon sheath. Radiol Med; 2010 Feb;115(1):141-51

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Imaging of giant cell tumour of the tendon sheath.
  • Giant cell tumours of the tendon sheath (GCTTS) and pigmented villonodular synovitis (PVNS) are part of a spectrum of benign proliferative lesions of synovial origin that may affect the joints, bursae and tendon sheaths.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Neoplasms, Connective Tissue / diagnosis. Synovitis, Pigmented Villonodular / diagnosis. Tendons / pathology
  • [MeSH-minor] Diagnosis, Differential. Echo-Planar Imaging. Humans. Magnetic Resonance Imaging. Predictive Value of Tests. Sensitivity and Specificity. Ultrasonography, Doppler

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  • (PMID = 20077044.001).
  • [ISSN] 1826-6983
  • [Journal-full-title] La Radiologia medica
  • [ISO-abbreviation] Radiol Med
  • [Language] eng; ita
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 49
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96. Reece PH, Lwin KY, Gurr PA: Tenosynovial giant cell tumour of the neck. Eur Arch Otorhinolaryngol; 2006 Jun;263(6):598-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tenosynovial giant cell tumour of the neck.
  • We report the case of a diffuse tenosynovial giant cell tumour to be found adjacent to the thyroid gland.
  • These tumours, also known as extra-articular pigmented villonodular synovitis, are found more commonly in the fingers, wrist, knee thigh and foot, rarely in the head and neck.
  • These tumours are prone to local recurrence, require a high clinical index of suspicion and if they have atypical features may be extremely difficult to obtain a histological diagnosis.
  • [MeSH-major] Giant Cell Tumors / diagnosis. Head and Neck Neoplasms / diagnosis. Synovitis, Pigmented Villonodular / diagnosis

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  • (PMID = 16552611.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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97. Matsushige T, Nakaoka M, Yahara K, Kagawa K, Miura H, Ohnuma H, Kurisu K: Giant cell tumor of the temporal bone with intratumoral hemorrhage. J Clin Neurosci; 2008 Aug;15(8):923-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumor of the temporal bone with intratumoral hemorrhage.
  • We report a case of hemorrhagic giant cell tumor (GCT) of the temporal bone in a 77-year-old woman.
  • Subsequent MRI revealed tumor growth with multiple cystic components at 1-month follow up.
  • The tumor was found to be a GCT associated with recent intratumoral hemorrhage and abundant hemosiderin pigmentation.
  • T(2)-weighted MRI of the GCT strongly supported hemosiderin deposition.
  • Secondary formation of cystic components in the GCT can also reflect prior hemorrhage and indicate the progression of shape modification.
  • [MeSH-major] Bone Neoplasms / complications. Giant Cell Tumor of Bone / complications. Hemorrhage / complications. Temporal Bone / pathology

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  • (PMID = 18554912.001).
  • [ISSN] 0967-5868
  • [Journal-full-title] Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
  • [ISO-abbreviation] J Clin Neurosci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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98. Singh AP, Mahajan S, Singh AP: Giant cell tumour of the proximal radius. Singapore Med J; 2009 Nov;50(11):e388-90
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Giant cell tumour of the proximal radius.
  • The patient was diagnosed to have Campanacci grade III giant cell tumour of the proximal radius, and was treated with above elbow amputation.
  • The case was reported because of its rarity and the unusual site of occurrence of the tumour.
  • [MeSH-major] Bone Neoplasms / diagnosis. Giant Cell Tumor of Bone / diagnosis. Radius / radiography

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  • (PMID = 19960152.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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99. Cozzolino A, Balleri P, Ruggiero G, Veltri M: Use of short implants for functional restoration of the mandible after giant cell tumor removal. Case report. Minerva Stomatol; 2006 May;55(5):307-14

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Use of short implants for functional restoration of the mandible after giant cell tumor removal. Case report.
  • The giant cell tumor of the jaws is a rare benign lesion, it has a slow and progressive evolution and it is locally aggressive.
  • The clinical case of a 28-year-old man affected by a giant cell tumor of the mandible with an aggressive clinical and radiographical behaviour is reported.
  • The giant cell tumor diagnosis was made with orthopantomography (OPT), computed tomography (CT) and needle biopsy.
  • In this case short implants allowed the prosthetic rehabilitation of a mandible with severe ''resorption'' due to surgical removal of a tumor.
  • [MeSH-major] Dental Implantation, Endosseous. Dental Implants. Giant Cell Tumor of Bone / surgery. Mandibular Neoplasms / surgery

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  • (PMID = 16688107.001).
  • [ISSN] 0026-4970
  • [Journal-full-title] Minerva stomatologica
  • [ISO-abbreviation] Minerva Stomatol
  • [Language] eng; ita
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Dental Implants
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100. Zahid M, Asif N, Sabir AB, Siddiqui YS, Julfiqar M: Metachronous multicentric giant cell tumour of the upper extremity in a skeletally immature girl : A rare presentation. Acta Orthop Belg; 2010 Oct;76(5):694-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metachronous multicentric giant cell tumour of the upper extremity in a skeletally immature girl : A rare presentation.
  • Giant Cell tumour (GCT) or Osteoclastoma is a benign locally aggressive tumour with a tendency for local recurrence.
  • GCT constitutes 5% of all primary bone tumours.
  • Metachronous multicentric giant cell tumour of bone is a rare entity.
  • Multicentric GCT, in contrast to unifocal GCT, has a tendency to involve the small bones of hands and feet, involving the metaphysis/diaphysis of long bones and tends to occur in a slightly younger population.
  • We report a young girl presenting with metachronous multicentric recurrent benign GCT, with the lesions involving the ipsilateral right hand and distal humerus.
  • [MeSH-major] Bone Neoplasms / pathology. Giant Cell Tumor of Bone / pathology. Hand Bones. Humerus. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adolescent. Female. Humans. Neoplasm Recurrence, Local

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  • (PMID = 21138229.001).
  • [ISSN] 0001-6462
  • [Journal-full-title] Acta orthopaedica Belgica
  • [ISO-abbreviation] Acta Orthop Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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