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1. Matsumoto L, Yamamoto T, Higashihara M, Sugimoto I, Kowa H, Shibahara J, Nakamura K, Shimizu J, Ugawa Y, Goto J, Dalmau J, Tsuji S: Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes. Mov Disord; 2007 Apr 15;22(5):728-31
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  • [Title] Severe hypokinesis caused by paraneoplastic anti-Ma2 encephalitis associated with bilateral intratubular germ-cell neoplasm of the testes.
  • We report a 40-year-old man with severe hypokinesis as paraneoplastic manifestation of a microscopic "carcinoma in situ" of the testis.
  • The young age of the patient, along with progressive neurologic deterioration, detection of anti-Ma2 antibodies, and ultrasound findings of bilateral microcalcifications, led to bilateral orchiectomy, revealing the tumor in both testes.

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  • (PMID = 17269131.001).
  • [ISSN] 0885-3185
  • [Journal-full-title] Movement disorders : official journal of the Movement Disorder Society
  • [ISO-abbreviation] Mov. Disord.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA089054-05; United States / NCI NIH HHS / CA / CA107192-03; United States / NCI NIH HHS / CA / R01 CA107192; United States / NCI NIH HHS / CA / CA089054-05; United States / NCI NIH HHS / CA / R01 CA089054; United States / NCI NIH HHS / CA / R01 CA107192-03
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Autoantibodies; 0 / Ma2 antigen; 0 / Nerve Tissue Proteins
  • [Other-IDs] NLM/ NIHMS24643; NLM/ PMC1909751
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2. Takahashi S, Yoshida K, Mikami S, Oya M, Kawase T: Development of testicular alpha-fetoprotein-secreting germ cell tumor 3 years after treatment of intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data--case report. Neurol Med Chir (Tokyo); 2008;48(11):522-5
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  • [Title] Development of testicular alpha-fetoprotein-secreting germ cell tumor 3 years after treatment of intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data--case report.
  • A 22-year-old Asian male developed testicular alpha-fetoprotein (AFP)-secreting germ cell tumor 3 years after treatment of a disseminated intracranial lesion identified as non-secreting germ cell tumor on the basis of clinical data.
  • Left orchidectomy was performed and histological examination indicated the presence of AFP-secreting germ cell tumor despite severe necrosis of the tissue.
  • Improved chemoradiotherapy for intracranial germ cell tumor will lead to long-term survival of most patients with germ cell tumor.
  • Patients may subsequently develop germ cell tumors at other sites in the body.
  • Therefore, follow up should monitor for tumor recurrence not only in the brain but also in other locations.
  • [MeSH-major] Neoplasm Proteins / analysis. Neoplasms, Germ Cell and Embryonal / secondary. Supratentorial Neoplasms / pathology. Testicular Neoplasms / secondary. alpha-Fetoproteins / analysis
  • [MeSH-minor] Carboplatin / administration & dosage. Combined Modality Therapy. Cranial Irradiation. Disease-Free Survival. Etoposide / administration & dosage. Follow-Up Studies. Hemianopsia / etiology. Humans. Magnetic Resonance Imaging. Male. Neoplasms, Second Primary / secretion. Neoplasms, Second Primary / surgery. Orchiectomy. Young Adult

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  • (PMID = 19029782.001).
  • [ISSN] 1349-8029
  • [Journal-full-title] Neurologia medico-chirurgica
  • [ISO-abbreviation] Neurol. Med. Chir. (Tokyo)
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / alpha-Fetoproteins; 6PLQ3CP4P3 / Etoposide; BG3F62OND5 / Carboplatin
  • [Number-of-references] 12
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3. Neumann JC, Dovey JS, Chandler GL, Carbajal L, Amatruda JF: Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish; 2009 Dec;6(4):319-27
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  • [Title] Identification of a heritable model of testicular germ cell tumor in the zebrafish.
  • Germ cell tumors (GCTs) affect infants, children, and adults and are the most common cancer type in young men.
  • Here we report the identification of a zebrafish model of highly penetrant, heritable testicular GCT isolated as part of a forward genetic screen for cancer susceptibility genes.
  • The mutant line develops spontaneous testicular tumors at a median age of 7 months, and pedigree analysis indicates dominant inheritance of the GCT susceptibility trait.
  • The zebrafish model exhibits disruption of testicular tissue architecture and the accumulation of primitive, spermatogonial-like cells with loss of spermatocytic differentiation.
  • Radiation treatment leads to apoptosis of the tumor cells and tumor regression.
  • The GCT-susceptible line can serve as a model for understanding the mechanisms regulating germ cells in normal development and disease and as a platform investigating new therapeutic approaches for GCTs.

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  • (PMID = 20047465.001).
  • [ISSN] 1557-8542
  • [Journal-full-title] Zebrafish
  • [ISO-abbreviation] Zebrafish
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA135731; United States / NCI NIH HHS / CA / 1R01CA13573; United States / NCI NIH HHS / CA / CA135731-01; United States / NCI NIH HHS / CA / CA135731-02; United States / NCI NIH HHS / CA / R01 CA135731-01; United States / NCI NIH HHS / CA / R01 CA135731-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS145326; NLM/ PMC2811880
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4. Spiess PE, Brown GA, Pisters LL, Liu P, Tu SM, Evans JG, Kamat AM, Black P, Tannir NM: Viable malignant germ cell tumor in the postchemotherapy retroperitoneal lymph node dissection specimen: can it be predicted using clinical parameters? Cancer; 2006 Oct 1;107(7):1503-10
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  • [Title] Viable malignant germ cell tumor in the postchemotherapy retroperitoneal lymph node dissection specimen: can it be predicted using clinical parameters?
  • BACKGROUND: The presence of viable tumor in the surgical specimen after postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) is associated with an increased risk of disease progression.
  • The objective of this study was to determine whether the presence of viable tumor in the surgical specimen could be predicted.
  • METHODS: Between 1980 and 2003, 236 patients underwent PC-RPLND for clinical Stage IIA or III nonseminomatous germ cell tumors (NSGCT).
  • A multivariate logistic regression analysis was used to evaluate whether clinical parameters were capable of predicting the presence of viable tumor in the surgical specimen.
  • RESULTS: International Germ Cell Consensus Classification (IGCCC) risk categories could be assigned to 218 patients, with 101 patients in the good-risk category, 32 patients in the intermediate-risk category, and 85 patients in the poor-risk category.
  • The incidence of viable tumor in the good-risk, intermediate-risk, and poor-risk categories was similar (17.8%, 15.6%, and 15.3%, respectively); however, the risk categories predicted disease-specific and recurrence-free survival (P = .022 and P < .0001, respectively).
  • On multivariate analysis, an elevated serum alpha-fetoprotein (AFP) level prior to PC-RPLND (P = .05) and the size of the retroperitoneal mass on pathology review (P = .02) were predictive of viable tumor in the surgical specimen.
  • CONCLUSIONS: Although IGCCC risk categories were correlated with disease-related outcomes, the risk groups had similar incidences of viable tumor.
  • Elevated serum AFP levels prior to surgery and the size of the retroperitoneal mass in the resected specimen may help to predict viable tumor in the PC-RPLND specimen.
  • [MeSH-major] Lymph Nodes / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Testicular Neoplasms / drug therapy. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Biomarkers, Tumor / blood. Disease-Free Survival. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Pathology, Surgical. Prognosis. Retroperitoneal Space. Risk. alpha-Fetoproteins / analysis

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  • [Copyright] (c) 2006 American Cancer Society.
  • (PMID = 16944534.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / alpha-Fetoproteins
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5. Armah HB, Rao UN, Parwani AV: Primary angiosarcoma of the testis: report of a rare entity and review of the literature. Diagn Pathol; 2007;2:23
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  • [Title] Primary angiosarcoma of the testis: report of a rare entity and review of the literature.
  • Histologically, all showed classic anastomosing channels lined by plump hyperchromatic cells, though most showed epithelioid cytology and some showed solid architectural pattern.
  • One patient had multiple metastatic recurrences but eventual outcome was not available, and 1 patient died a month after diagnosis from stroke but no autopsy was performed.
  • CONCLUSION: Primary testicular angiosarcomas are typically rare tumors of men of all ages that appear to segregate into 2 groups; one associated with teratoma and occurring in young people, and the other occurring in the elderly and not associated with germ cell neoplasm, but may be associated with chronic hydrocele.

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  • (PMID = 17601346.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1919353
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6. Bi WL, Bannykh SI, Baehring J: The Growing Teratoma Syndrome after Subtotal Resection of an Intracranial Nongerminomatous Germ Cell Tumor in an Adult: Case Report. Neurosurgery; 2005 Jan 01;56(1):E191-E194

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  • [Title] The Growing Teratoma Syndrome after Subtotal Resection of an Intracranial Nongerminomatous Germ Cell Tumor in an Adult: Case Report.

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  • (PMID = 28184632.001).
  • [ISSN] 1524-4040
  • [Journal-full-title] Neurosurgery
  • [ISO-abbreviation] Neurosurgery
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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7. Amendola BE, Wolf A, Coy SR, Amendola MA, Eber D: Pineal tumors: analysis of treatment results in 20 patients. J Neurosurg; 2005 Jan;102(s_supplement):175-179

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pineal tumors: analysis of treatment results in 20 patients.
  • OBJECT: The authors evaluate their results when using gamma knife surgery (GKS) in the management of patients with tumors in the pineal region.
  • METHODS: This is a retrospective clinical evaluation of 20 patients with primary tumors of the pineal region treated with GKS from November 1994 through August 2003.
  • There were 13 germ cell tumors, two pineoblastomas, two low-grade gliomas, one primitive neuroectodermal tumor, one teratoma, and one pineocytoma.
  • Three patients died: one of unrelated causes, one who presented with extensive local disease, and the other of meningeal carcinomatosis with local control of the primary tumor.
  • CONCLUSIONS: This initial experience suggests that GKS is a valuable treatment modality for the management of pineal region tumors.
  • This technique offers excellent local tumor control and minimal patient morbidity, allowing for immediate use of systemic chemotherapy and/or conventional radiation if indicated.

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  • (PMID = 28306462.001).
  • [ISSN] 1933-0693
  • [Journal-full-title] Journal of neurosurgery
  • [ISO-abbreviation] J. Neurosurg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Keywords] NOTNLM ; gamma knife surgery / glioma / pineal tumor / pineoblastoma / pineocytoma / primitive neuroectodermal tumor / teratoma
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8. Rejlekova K, Mego M, Rajec J, Sycova-Mila Z, Obertova J, Mardiak J: A rare case of malignant extragonadal germ cell tumor in the pineal region with an aggressive behaviour. Bratisl Lek Listy; 2009;110(5):296-7
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  • [Title] A rare case of malignant extragonadal germ cell tumor in the pineal region with an aggressive behaviour.
  • Though germ cell cancer is rare, it is the most common cancer in males between 20 and 40 years.
  • The primary site for the development of germ cell tumor is testes, but it can be seen in extragonadal locations as well.
  • Herein, we present a rare case of a 19-year-old patient with non/seminomatous extragonadal germ cell tumor in the pineal region with an aggressive behaviour, refractory to the combined therapy (surgery, radio- and chemotherapy).
  • We suggest that early diagnosis and aggressive multimodal approaches along with surgery, radiotherapy and chemotherapy is necessary to improve the outcome of these patients (Ref. 5).
  • [MeSH-major] Brain Neoplasms. Neoplasms, Germ Cell and Embryonal. Pineal Gland

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  • (PMID = 19507665.001).
  • [ISSN] 0006-9248
  • [Journal-full-title] Bratislavské lekárske listy
  • [ISO-abbreviation] Bratisl Lek Listy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Slovakia
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9. Mann O, Kleinhans H, Gebauer F, Kaifi J, Schurr PG, Izbicki JR, Strate TG: [Intrathoracic lesions in association with germ cell tumor of the testis]. Chirurg; 2008 Sep;79(9):874-6
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  • [Title] [Intrathoracic lesions in association with germ cell tumor of the testis].
  • [Transliterated title] Bihiläre Lymphome bei nichtseminomatösem Keimzelltumor.
  • The present case of a young man with intrathoracic lesions in association with a germ-cell tumor of the testis turned out to have sarcoidosis mimicking testicular cancer relapse.
  • [MeSH-major] Germinoma / complications. Sarcoidosis, Pulmonary / complications. Sarcoidosis, Pulmonary / diagnosis. Testicular Neoplasms / complications
  • [MeSH-minor] Adult. Antineoplastic Combined Chemotherapy Protocols. Bleomycin. Chemotherapy, Adjuvant. Cisplatin. Diagnosis, Differential. Etoposide. Humans. Laparoscopy. Lymph Node Excision. Lymphatic Diseases / radiography. Lymphatic Diseases / radionuclide imaging. Male. Neoplasm Staging. Positron-Emission Tomography. Radiography, Thoracic. Testis / pathology. Thoracotomy. Tomography, X-Ray Computed

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  • (PMID = 18209992.001).
  • [ISSN] 0009-4722
  • [Journal-full-title] Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
  • [ISO-abbreviation] Chirurg
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; BEP protocol
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10. Ishioka J, Kageyama Y, Inoue M, Fukui N, Numao N, Saito K, Ichiyanagi N, Tanak M, Hyochi N, Fukuda H, Higashi Y: [Result of treatment for advanced germ cell tumor in the last decade]. Nihon Hinyokika Gakkai Zasshi; 2010 Mar;101(3):539-46
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  • [Title] [Result of treatment for advanced germ cell tumor in the last decade].
  • PURPOSE: We retrospectively analyzed our therapeutic results of advanced male germ cell tumors in terms of efficacy and feasibility of our treatment strategy.
  • Primary site of the tumor was testis in 41 (80%) patients, retroperitoneum in 6 (12%), and mediastinum in 4 (8%).
  • Histology of the primary germ cell tumor was pure seminoma in 14 (27%), and non-seminoma in 30 (59%).
  • Twenty (39%), 14 (27%) and 17 (33%) were classified as good-, intermediate-, and poor-risk, retrospectively, based on The International Germ Cell Consensus Classification (IGCCC) criteria.
  • Marker-negative cases with residual tumors underwent surgical resection of the mass lesion.
  • After two courses of initial chemotherapy, tumor marker decline was satisfactory in 37 patients (73%) and unsatisfactory in 14 (27%).
  • CONCLUSIONS: In this IGCCCG era, 5 year survival rates of the advanced germ cell tumors have improved by the earlier administration of second line chemotherapies based on both the prognostic factor-based staging system and the tumor marker decline in initial chemotherapy.
  • Development of effective treatment for cases with unfavorable tumor maker decline is the most challenging issue to be addressed.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / drug therapy. Neoplasms, Germ Cell and Embryonal / drug therapy. Retroperitoneal Neoplasms / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Adolescent. Adult. Biomarkers, Tumor. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Etoposide / administration & dosage. Female. Humans. Ifosfamide / administration & dosage. Male. Middle Aged. Prognosis. Retrospective Studies. Salvage Therapy. Young Adult

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  • (PMID = 20387513.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; BEP protocol; ICE protocol 1
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11. Zhou ZT, Wang JW, Yang L, Wang J, Zhang W: [Primary germ cell tumor in the mediastinum-report of 47 cases]. Zhonghua Zhong Liu Za Zhi; 2006 Nov;28(11):863-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary germ cell tumor in the mediastinum-report of 47 cases].
  • OBJECTIVE: To investigate the clinical characterstics, effective treatment and prognosis in patients with primary germ cell tumors in the mediastinum.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy. Seminoma / therapy

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  • (PMID = 17416013.001).
  • [ISSN] 0253-3766
  • [Journal-full-title] Zhonghua zhong liu za zhi [Chinese journal of oncology]
  • [ISO-abbreviation] Zhonghua Zhong Liu Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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12. Moschovi M, Alexiou GA, Dastamani A, Stefanaki K, Prodromou N, Hatzigiorgi H, Karamolegou K, Tzortzatou-Stathopoulou F: Alpha-fetoprotein secretion in a craniopharyngioma. Are craniopharyngiomas part of the germ cell tumor family? Acta Neurol Belg; 2010 Sep;110(3):272-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alpha-fetoprotein secretion in a craniopharyngioma. Are craniopharyngiomas part of the germ cell tumor family?
  • These findings were suggestive for a brain germ cell tumor.
  • After two courses there was a reduction in the levels of AFP but the tumor size remained unchanged.
  • Subtotal tumor excision was performed that revealed the presence of a craniopharyngioma.
  • One month later there was enlargement of the cystic part of the tumor, while serum AFP was elevated.
  • The child received again systemic chemotherapy and placement of a reservoir into the cystic part of the tumor.
  • These observations support the theory of a germ cell tumor family, in which craniopharyngioma and germ cell tumor present the two sides of the same entity, while between them a wide variety of tumors, with variable type of secretion of AFP and/or beta-HCG, may exist.
  • [MeSH-major] Craniopharyngioma. Neoplasms, Germ Cell and Embryonal / classification. Pituitary Neoplasms. alpha-Fetoproteins / secretion

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  • (PMID = 21114138.001).
  • [ISSN] 0300-9009
  • [Journal-full-title] Acta neurologica Belgica
  • [ISO-abbreviation] Acta Neurol Belg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / AFP protein, human; 0 / alpha-Fetoproteins
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13. Harland SJ, Welch R, Huddart R, Stenning S, Pollock P, Gabe R: On the necessity for postchemotherapy surgery for residual abdominal masses in metastatic nonseminomatous germ cell tumors (NSGCT) of testis. J Clin Oncol; 2009 May 20;27(15_suppl):5088

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] On the necessity for postchemotherapy surgery for residual abdominal masses in metastatic nonseminomatous germ cell tumors (NSGCT) of testis.
  • : 5088 Background: Residual abdominal masses after chemotherapy for metastatic NSGCT of testis may contain viable tumor-derived tissue which can be a nidus for relapse of disease, particularly when the tissue is frankly malignant.

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  • (PMID = 27964289.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. Massard C, Huguet H, Kramar A, Beyer J, Hartmann JT, Lorch A, Pico J, Rosti G, Droz J, Fizazi K: Cross-validation of a new prognostic index integrating tumor marker decline in patients with relapsed disseminated germ cell tumors. J Clin Oncol; 2009 May 20;27(15_suppl):5086

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cross-validation of a new prognostic index integrating tumor marker decline in patients with relapsed disseminated germ cell tumors.
  • : 5086 Background: Early serum tumor marker decline during chemotherapy was previously shown to be prognostic for progression-free survival (PFS) and overall survival (OS) in patients with relapsed GCT in an analysis of the IT94 phase III trial, which compared conventional chemotherapy versus high dose chemotherapy (Massard C, ASCO 2008.
  • METHODS: Data on tumor site, response to first line chemotherapy, serum tumor markers at baseline and after two cycles of chemotherapy were obtained from 235 patients accrued in the IT94 trial (training set) and from 181 patients included in phase III prospective trials of high-dose chemotherapy conducted by the German GCT group (Lorch et al, J Clin Oncol.
  • CONCLUSIONS: AFP decline during the first 6 weeks of salvage chemotherapy and a mediastinal primary tumor site predict for PFS and OS in patients with relapsed disseminated GCT.

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  • (PMID = 27964274.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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15. Piulats JM Sr, Nadal M, Martinez-Iniesta M, Puertas S, Gonzalez S, Vidal A, Condom E, Germa-Lluch J, Garcia Del Muro X, Villanueva A: Nude mice model of primary human nonseminoma germ cell tumors to study biology and resistance to cisplatin treatment. J Clin Oncol; 2009 May 20;27(15_suppl):e16143

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nude mice model of primary human nonseminoma germ cell tumors to study biology and resistance to cisplatin treatment.
  • : e16143 Testicular germ cell tumors (TGCTs) are the most common malignancy in young men.
  • Recently, our group has reported the development of a model of human nonseminoma (NSE) after orthotopic nude mice implantation (Piulats et al, Amer Assoc Cancer Res. 2006).
  • Pure and mix NSE anatomies were represented and they reproduce the main histological, genetic and epigenetic characteristics of paired primary tumors.
  • Xenografts mimic distal dissemination patterns and cisplatin (CDDP) tumor behavior responses.
  • We have generated in vivo five tumors showing increased resistance to CDDP by exposition to repetitive cycles and increasing the dose applied through different passages (1 yolk-sac; 1 choriocarcinoma; 2 embrional carcinoma; 1 mix tumor).
  • A shortness time elipse between pasajes was observed for each tumor through CDDP treatments.
  • To confirm increasin resistance, a parallel assay of chemotherapy response was performed between nontreated and CDDP resistant tumors.
  • Whole genome analysis of tour xenografted tumors and their paired CDDP resistant tumor (#3 and #5 passage) were analyzed by CGH NimbeGen arrays using 60 Kb average windows.
  • Few differential genomic changes were identified some of them were consistent across resistant tumors including gain of 9q21.11-9q33.3, 15q23-15q24.1, and 15q26.3 regions and loss of Xp22.33.
  • In one tumour showing strong CDDP resistance compared with its sensitive counterpart it occur in absence of new genomic changes.
  • No changes in the MSI or mutational TP53 status were observed in resisant tumors.
  • Our data suggest that acquisition of tumor resistance to CDDP in TGCTs may proably depend of a combination of different mechanisms, including cromosomal imbalances.

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  • (PMID = 27963427.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Brames M, Ehrlich Y, Einhorn L: Malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): Outcome analysis with PNET based chemotherapy. J Clin Oncol; 2009 May 20;27(15_suppl):e16121

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant transformation of teratoma to primitive neuroectodermal tumor (PNET): Outcome analysis with PNET based chemotherapy.
  • RESULTS: 9 of 10 patients had at least 1 prior platinum based combination chemotherapy regimen for their germ cell tumor.
  • Tumor markers (human chorionic gonadotropin and alphafetoprotein) were normal at start of chemotherapy for biopsy proven PNET.

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  • (PMID = 27963389.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Lorch A, Beyer J, Mollevi C, Guerra M, Kramar A, International Group on Prognostic Factors in Relapsed or Refractory Germ-Cell Tumors: Prognostic factors in relapsed or refractory male germ cell tumors: Results from an international study of 1,593 patients. J Clin Oncol; 2009 May 20;27(15_suppl):5030

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors in relapsed or refractory male germ cell tumors: Results from an international study of 1,593 patients.
  • : 5030 Background: The results of salvage treatment in male patients (pts) with relapsed or refractory germ-cell tumors (rr-GCT) depend considerably on prognostic factors.
  • CONCLUSIONS: This preliminary analysis of a large dataset allowed the identification of important prognostic factors in rr- GCT.
  • A prognostic score for first-salvage treatment based on the results of a final analysis will be presented.

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  • (PMID = 27962922.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Lotz J, Selle F, Fizazi K, Gravis G, Bui B, Delva R, Bay J, Baron A, Robain M, Biron P: A phase II trial of high-dose chemotherapy (HDCT) supported by haematopoietic stem cell transplantation (HSCT) in patients (pts) with disseminated germ-cell tumors (GCTs) failing chemotherapy and with adverse prognostic factors: The TAXIF II protocol. J Clin Oncol; 2009 May 20;27(15_suppl):5028

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A phase II trial of high-dose chemotherapy (HDCT) supported by haematopoietic stem cell transplantation (HSCT) in patients (pts) with disseminated germ-cell tumors (GCTs) failing chemotherapy and with adverse prognostic factors: The TAXIF II protocol.

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  • (PMID = 27962914.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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19. Wheater MJ, Huddart R, White J, Rustin G, Abab J, Mead GM: Salvage chemotherapy with gemcitabine, paclitaxel, ifosphamide, and cisplatin (Gem-TIP) for relapsed germ cell tumours (GCT). J Clin Oncol; 2009 May 20;27(15_suppl):e16031

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salvage chemotherapy with gemcitabine, paclitaxel, ifosphamide, and cisplatin (Gem-TIP) for relapsed germ cell tumours (GCT).
  • All patients received TIP without dose reduction (paclitaxel 175 mg/m2 d1, cisplatin 20 mg/m2 d1-5, ifosphamide 1 g/m2 d2-6) with GCSF days 7-18 of a 21 day cycle for maximum 4 cycles.

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  • (PMID = 27962963.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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20. Nakamura T, Nonomura N, Mikami K, Shiraishi T, Takaha N, Okuyama A, Miki T: Salvage chemotherapy with irinotecan and nedaplatin for cisplatin refractory germ cell tumors. J Clin Oncol; 2009 May 20;27(15_suppl):e16022

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salvage chemotherapy with irinotecan and nedaplatin for cisplatin refractory germ cell tumors.
  • : e16022 Background: Only 20 - 30 % of patients with cisplatin (CDDP) refractory germ cell tumor (GCT) will remain continuously disease-free with salvage chemotherapy.
  • After tumor marker normalization, residual masses were resected and chemotherapy was continued in the case of without marker normalization.

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  • (PMID = 27962980.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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21. Feldman DR, Sheinfeld J, Bajorin DF, Fischer P, Turkula S, Ishill N, Patil S, Bains M, Bosl GJ, Motzer RJ: Paclitaxel (T) plus ifosfamide (I) followed by high-dose carboplatin (C) and etoposide (E) with autologous stem cell support for patients (pts) with previously treated germ cell tumors (GCT): TI-CE results and prognostic factor analysis in 107 pts. J Clin Oncol; 2009 May 20;27(15_suppl):5027

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paclitaxel (T) plus ifosfamide (I) followed by high-dose carboplatin (C) and etoposide (E) with autologous stem cell support for patients (pts) with previously treated germ cell tumors (GCT): TI-CE results and prognostic factor analysis in 107 pts.

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  • (PMID = 27962915.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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22. Grimison PS, Stockler MR, Thomson DB, Olver IN, Harvey VJ, Gurney H, Lewis CR, Gebski VJ, Boland AL, Toner GC, Australia and New Zealand Germ Cell Trials Group: Comparison of two standard chemotherapy regimens for good-prognosis germ-cell tumors: Updated analysis of a randomized trial with 8 years follow-up. J Clin Oncol; 2009 May 20;27(15_suppl):5016

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of two standard chemotherapy regimens for good-prognosis germ-cell tumors: Updated analysis of a randomized trial with 8 years follow-up.
  • : 5016 Background: We performed a multicentre randomised trial for good-prognosis germ-cell tumours of two standard chemotherapy regimens containing bleomycin (B), etoposide (E) and cisplatin (P).

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  • (PMID = 27962901.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Malogolowkin MH, Krailo M, Frazier LA, Olson TA: Study of cisplatin, etoposide, bleomycin, and escalating dose cyclophosphamide therapy for children with high-risk germ cell tumors: A Children's Oncology Group report. J Clin Oncol; 2009 May 20;27(15_suppl):10035

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Study of cisplatin, etoposide, bleomycin, and escalating dose cyclophosphamide therapy for children with high-risk germ cell tumors: A Children's Oncology Group report.
  • : 10035 Background: In the intergroup high-risk germ cell tumors (HR-GCT) study (CCG-8882/POG-9049) patients with extragonadal GCT treated with high-dose cisplatin, etoposide, and bleomycin (HD-PEB) had a 2 year-EFS of 84% versus 74% for those treated with standard PEB (PEB), suggesting that treatment intensification might be beneficial.
  • Four patients received 2 more cycles of C-PEB, of these 3 were disease-free and 1 had PD.

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  • (PMID = 27962582.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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24. Boyle H, You B, Fronton L, Ribba B, Girard P, Tranchand B, Tod M, Coquelin H, Droz J, Flechon A: Major prognostic value of modeled AUC&lt;sub&gt;hCG-AFP&lt;/sub&gt;, a dynamic kinetic marker characterizing tumor marker decline of nonseminomatous germ cell tumors (NSGCT) intermediate-poor-risk patients according to the IGCCCG. J Clin Oncol; 2009 May 20;27(15_suppl):5085

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Major prognostic value of modeled AUC<sub>hCG-AFP</sub>, a dynamic kinetic marker characterizing tumor marker decline of nonseminomatous germ cell tumors (NSGCT) intermediate-poor-risk patients according to the IGCCCG.
  • : 5085 Background: The level of human chorionic gonadotrophin (hCG) and alpha-foetoprotein (AFP) serum tumor marker is well established in NSGCT as prognostic factor, the relevance of marker kinetic analysis under treatment is still unclear.

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  • (PMID = 27964275.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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25. Beyer J, Hackenthal M, Lorch A, Neubauer A, Dieing A, Rick O, Hartmann JT, Bokemeyer C: High-dose chemotherapy (HDCT) as second salvage treatment in patients with multiple relapsed or refractory germ cell tumors. J Clin Oncol; 2009 May 20;27(15_suppl):5082

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] High-dose chemotherapy (HDCT) as second salvage treatment in patients with multiple relapsed or refractory germ cell tumors.
  • : 5082 Background: To determine the activity of high-dose chemotherapy (HDCT) as intensification of second salvage treatment (SST) in patients with multiple relapsed germ-cell tumors (GCT).
  • METHODS: Databases in Berlin and Marburg (Germany) on patients treated with HDCT between 1989 and 2008 for germ-cell tumors were screened.

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  • (PMID = 27964281.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Necchi A, Colecchia M, Nicolai N, Mego M, De Giorgi U, Mikuz G, Sava T, Di Nicola M, Pastorino U, Salvioni R: Somatic malignant differentiation in adult male germ-cell tumors (GCTs): Preliminary evidences from the INTera database (International Project for Teratoma with Malignant Transformation). J Clin Oncol; 2009 May 20;27(15_suppl):e16013

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Somatic malignant differentiation in adult male germ-cell tumors (GCTs): Preliminary evidences from the INTera database (International Project for Teratoma with Malignant Transformation).
  • 25 pts had MT in primary tumor: 14 of them had no metastases (11 underwent primary retroperitoneal lymph-node dissection - RPLND), and 11 underwent chemotherapy (CT) ± surgery due to metastatic disease.

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  • (PMID = 27962924.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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27. Nicolai N, Biasoni D, Piedra Aguilera J, Necchi A, Piva L, Stagni S, Torelli T, Milani A, Pizzocaro G, Salvioni R: Open versus laparoscopic retroperitoneal lymph node dissection (RPLND) in clinical stage I nonseminomatous germ-cell tumors (NSGCTs): Two contemporary series from a single institution. J Clin Oncol; 2009 May 20;27(15_suppl):5084

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Open versus laparoscopic retroperitoneal lymph node dissection (RPLND) in clinical stage I nonseminomatous germ-cell tumors (NSGCTs): Two contemporary series from a single institution.
  • Pts with high risk disease (vascular invasion/embryonal carcinoma > 90% in the primary tumor) were more frequently offered O-RPLND, while pts with low risk disease (none of the 2 above) were usually considered for L-RPLND.

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  • (PMID = 27964277.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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28. Hartmann JT, Aschoff P, Dittmann H, Lichy M, Mayer F, Reischl G, von Weyhern C, Kanz L, Claussen CD, Pfannenberg C: The value of PET/CT with 18F-FLT and 18F-FDG in the management of metastatic germ cell tumors (GCT): A pilot study. J Clin Oncol; 2009 May 20;27(15_suppl):e16142

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The value of PET/CT with 18F-FLT and 18F-FDG in the management of metastatic germ cell tumors (GCT): A pilot study.
  • : e16142 Background: The purpose is to assess the ability of [F-18]-3'-Fluoro-3'-deoxythymidin (FLT), a cell proliferation marker, for early response monitoring and prediction of histology of residual tumor masses in patients (pts) with metastatic GCT in comparison to the standard tracer F-18-FDG, CT-scans and tumor markers.
  • Regarding early tumor response EORTC criterias were used.
  • Examination of resected masses revealed necrosis in 3/7, teratoma in 2/7 as well as 2/7 pts with viable tumors.

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  • (PMID = 27963433.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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29. Pezaro CJ, Toner GC, Hicks R: Staging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) for nonseminomatous germ cell tumor (NSGCT): The Peter MacCallum Cancer Centre experience. J Clin Oncol; 2009 May 20;27(15_suppl):e16140

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Staging with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) for nonseminomatous germ cell tumor (NSGCT): The Peter MacCallum Cancer Centre experience.
  • Previous studies by de Wit et al and the TE22 trial concluded that there was a very limited role for PET staging in NSGCT.

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  • (PMID = 27963431.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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30. Kebudi R, Darendeliler E, Ayan I, Gorgun O, Yaman Agaoglu F, Dizdar Y, Darendeliler F, Emiroglu H: Multimodality treatment on long-term outcome of intracranial germ cell tumors in children: A single institution study. J Clin Oncol; 2009 May 20;27(15_suppl):10063

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodality treatment on long-term outcome of intracranial germ cell tumors in children: A single institution study.
  • : 10063 Background: Intracranial germ cell tumors (iGCT) constitute 1% of all malignant neoplasms in children.
  • AFP and BHCG were evaluated at diagnosis and during therapy both in serum and CSF.
  • Two nongerminamatous iGCT patients died: 1 of widespread disease in the intensive care unit at diagnosis, the other with progressive disease 18 months after diagnosis.
  • Fourteen patients are alive at a median follow-up of 12 years (1-17 years) from diagnosis.
  • One that had motor and mental retardation before diagnosis needs special care.
  • The possibility of an early clinical diagnosis based on MRI and tumor markers and the use of modern neurosurgical techniques increases the chance of cure, gives a chance to reduce acute morbidity and further decrease late effects.

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  • (PMID = 27962498.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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31. Shim K, Potvin KR, Mills K, Whiston F, Stitt L, Winquist E: Risk factors for thromboembolic events in testicular cancer patients receiving chemotherapy. J Clin Oncol; 2009 May 20;27(15_suppl):e16109

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Clinical experience and the literature have suggested that men receiving cisplatin-based chemotherapy for metastatic germ cell tumors are at particularly high risk.
  • METHODS: All men treated with cisplatin-based chemotherapy for metastatic germ cell cancer at the London Regional Cancer Program from January 1978 to December 2007 were identified from electronic databases.
  • These data support the concept of PA for selected patients starting chemotherapy for metastatic germ cell cancer.

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  • (PMID = 27963332.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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32. Albers P, Bingöl C, Witthuhn R, de Geeter P: Complications of postchemotherapy residual tumor resection in patients with germ cell cancer. J Clin Oncol; 2009 May 20;27(15_suppl):e16077

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Complications of postchemotherapy residual tumor resection in patients with germ cell cancer.
  • : e16077 Background: Residual tumor resection (RTR) is mandatory in all patients with advanced germ cell tumors and visible residual disease after chemotherapy.
  • In 34%, residual tumor diameter was >5 cm.
  • In 25 of 98 patients a full bilateral RTR was necessary to remove all residual tumors.
  • The median residual tumor diameter in patients with full bilateral RTR without nerve-sparing was 10.9 cm (1.5-30) as opposed to 4.3 cm (0.5-20) in patients with modified template and/or nerve-sparing approaches (not significant).
  • All CTCAE grade III/VI complications like intraoperative hemorrhage (n=25, 11/25 bilateral RTR), postoperative lymphocele (n=8, 6/8 bilateral RTR), and retrograde ejaculation (15% with modified template and/or nerve-sparing, 100% with bilateral RTR) were significantly correlated with the residual tumor size and with the field of resection.
  • CONCLUSIONS: The complication rate of RTR is strongly related to the median residual tumor size and the extent of surgery.

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  • (PMID = 27963039.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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33. Kakimoto K, Ono Y, Meguro N, Takezawa K, Yoshida T, Arai Y, Usami M: Stage I nonseminomatous germ cell tumors of the testis: Clinical outcome of 45 patients on a surveillance protocol after orchiectomy alone at a single institution in Japan. J Clin Oncol; 2009 May 20;27(15_suppl):e16165

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Stage I nonseminomatous germ cell tumors of the testis: Clinical outcome of 45 patients on a surveillance protocol after orchiectomy alone at a single institution in Japan.
  • : e16165 Background: In Japan, risk-adapted treatment for patients with clinical stage I nonseminomatous germ cell tumor of the testis (NSGCTT) has been performed in very few institutions.
  • The patients were monitored at follow-up evaluation for tumor marker (AFP, beta-hCG) levels and by abdominal CT scan, chest x-ray, and physical examination.
  • Primary testis tumor samples were assessed for prognostic factors including lymphatic and/or vascular (LV) invasion and pathological components such as the presence of embryonal carcinoma.

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  • (PMID = 27963435.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Ehrlich Y, Brames MJ, Beck SD, Foster RS, Einhorn LH: Long-term follow-up of chemotherapy-induced remissions in patients with disseminated nonseminomatous germ cell tumors. J Clin Oncol; 2009 May 20;27(15_suppl):5029

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Long-term follow-up of chemotherapy-induced remissions in patients with disseminated nonseminomatous germ cell tumors.
  • : 5029 Background: There is controversy concerning management of patients (pts) with nonseminomatous germ cell tumor (NSGCT) who obtain a chemotherapy-induced complete radiographic (<1cm node diameter) and serologic remission (CR).
  • Proponents of mandatory RPLND cite a 20% to 30% rate of residual microscopic tumor, mostly teratoma, despite achieving CR.

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  • (PMID = 27962913.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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35. Fedyanin M, Tryakin A, Titov D, Zakharova T, Fainstein I, Figurin K, Polockii B, Sergeev J, Garin A, Tjulandin S: Importance of maintenance of dose intensity (DI) during induction chemotherapy (iCT) for metastatic nonseminomatous germ cell tumors (NSGCT). J Clin Oncol; 2009 May 20;27(15_suppl):e16063

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Importance of maintenance of dose intensity (DI) during induction chemotherapy (iCT) for metastatic nonseminomatous germ cell tumors (NSGCT).
  • : e16063 Background: Cisplatin- and etoposide-based CT allows curing the majority of patients (pts) with metastatic germ cell tumor.
  • There are limited data concerning the importance of maintenance of DI during iCT.
  • In the retrospective study we analyzed the role of DI of iCT on metastatic NSGCT.
  • DI was calculated for every drug and expressed in mg/m<sup>2</sup> per week.
  • In pts with the intermediate prognosis: DI of etoposide <80% (HR 4.73; 95 % CI 4.85-25.04) and presence of pulmonary metastases (HR 0.45, 95% Cl 0.203-0.977).
  • In IGCCCG poor prognostic group: DI of etoposide <80% (HR 1.82, 95% Cl 1.143-2.913).
  • CONCLUSIONS: Maintaining a DI of greater then 80% of etoposide during iCT, for the treatment metastatic NSGCT, is one of the crucial factors for pts outcome, particularly in intermediate and poor IGCCCG prognostic groups.

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  • (PMID = 27963067.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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36. Mardiak J, Rejlekova K, Mego M, Rajec J, Sycova-Mila Z, Obertova J, Salek T, Reckova M: Determination of efficacy of TIP combination (paclitaxel, ifosfamide, cisplatin) as first salvage therapy for patients with relapsed germ cell tumors in a poor prognosis group. J Clin Oncol; 2009 May 20;27(15_suppl):e16049

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Determination of efficacy of TIP combination (paclitaxel, ifosfamide, cisplatin) as first salvage therapy for patients with relapsed germ cell tumors in a poor prognosis group.
  • : e16049 Background: The efficacy of TIP appears to be suitable salvage therapy for patients with relapsed germ cell tumors (GCTs) with good prognostic features.The aim of our study was to determine the efficacy of TIP as first salvage therapy for patients with relapsed GCTs with poor prognostic features.
  • Sixteen (43%) patients had favorable prognostic features for response (testis primary tumor site and prior complete response to induction chemotherapy regimen) and 21 (57%) patients had poor prognostic features (either extragonadal site or incomplete response to induction chemotherapy regimen).

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  • (PMID = 27963009.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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37. Wang Z, Fan QH, Yu MN, Zhang WM: [Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system]. Zhonghua Bing Li Xue Za Zhi; 2006 Aug;35(8):458-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinicopathologic and immunohistochemical study of atypical teratoid/rhabdoid tumor of central nervous system].
  • OBJECTIVE: To study the clinicopathologic features and differential diagnosis of atypical teratoid/rhabdoid tumor (AT/RT) occurring in the central nervous system.
  • RESULTS: Histologically, AT/RT was characterized by the presence of rhabdoid cells associated with various degrees of primitive neuroectodermal, epithelial or mesenchymal differentiation.
  • The tumor cells were positive for vimentin, CD99, epithelial membrane antigen, cytokeratin, glial fibrillary acidic protein, S-100 protein, neurofilament, desmin and smooth muscle actin.
  • CONCLUSIONS: AT/RT is a highly malignant tumor occurring in the central nervous system.
  • The tumor is characterized by a heterogeneous histologic and immunohistochemical phenotype.
  • It needs to be distinguished from a number of central nervous system tumors, including medulloblastoma, primitive neuroectodermal tumor, germ cell neoplasm and rhabdoid meningioma.
  • [MeSH-major] Brain Neoplasms / pathology. Rhabdoid Tumor / pathology. Teratoma / pathology
  • [MeSH-minor] Actins / analysis. Adult. Antigens, CD / analysis. Cell Adhesion Molecules / analysis. Child, Preschool. Desmin / analysis. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Keratins / analysis. Male. Mucin-1 / analysis. Muscle, Smooth / chemistry. Neurofilament Proteins / analysis. S100 Proteins / analysis. Vimentin / analysis

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  • (PMID = 17069697.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Actins; 0 / Antigens, CD; 0 / CD99 protein, human; 0 / Cell Adhesion Molecules; 0 / Desmin; 0 / Glial Fibrillary Acidic Protein; 0 / Mucin-1; 0 / Neurofilament Proteins; 0 / S100 Proteins; 0 / Vimentin; 68238-35-7 / Keratins
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38. Tsuji T, Togami S, Shintomo N, Fukamachi N, Douchi T, Taguchi S: Ovarian large cell neuroendocrine carcinoma. J Obstet Gynaecol Res; 2008 Aug;34(4 Pt 2):726-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian large cell neuroendocrine carcinoma.
  • Ovarian large cell neuroendocrine carcinoma (LCNC) is a rare disease that is commonly associated with a surface epithelial and germ cell neoplasm component.
  • [MeSH-major] Carcinoma, Neuroendocrine / pathology. Ovarian Neoplasms / pathology. Ovary / pathology

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  • (PMID = 18840191.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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39. Gleizal A, Torossian JM, Wan DC, Béziat JL: Testicular carcinoma presenting as cutaneous nasal metastasis: case report and review of the literature. Br J Oral Maxillofac Surg; 2008 Jul;46(5):416-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Testicular choriocarcinoma is a highly malignant germ cell neoplasm, which metastasises to lungs, and brain.
  • This is the second reported case of a skin metastasis of choriocarcinoma to the head and neck, and the third in which a cutaneous metastasis was the first finding at initial presentation.
  • [MeSH-major] Choriocarcinoma / secondary. Nose Neoplasms / secondary. Skin Neoplasms / secondary. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Chorionic Gonadotropin, beta Subunit, Human / analysis. Fatal Outcome. Humans. Liver Neoplasms / secondary. Liver Neoplasms / surgery. Lung Neoplasms / secondary. Male. Retroperitoneal Neoplasms / secondary

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  • (PMID = 18155815.001).
  • [ISSN] 1532-1940
  • [Journal-full-title] The British journal of oral & maxillofacial surgery
  • [ISO-abbreviation] Br J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Scotland
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human
  • [Number-of-references] 13
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40. De Giorgi U, Pupi A, Fiorentini G, Rosti G, Marangolo M: FDG-PET in the management of germ cell tumor. Ann Oncol; 2005 May;16 Suppl 4:iv90-94
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG-PET in the management of germ cell tumor.
  • Germ cell tumor is the most common malignancy in young men.

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  • (PMID = 15923438.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 39
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41. Kawahara M, Takada A, Tachibana A, Kodama T, Kobayashi H, Takino Y, Sugishita T, Oono Y, Oka T: Germ cell tumor of the colon with an adenocarcinomatous component. Int J Clin Oncol; 2009 Dec;14(6):537-40

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  • [Title] Germ cell tumor of the colon with an adenocarcinomatous component.
  • A case of combined germ cell tumor and adenocarcinoma that arose in the colon of a 62-year-old man is described.
  • The patient had widespread metastases at diagnosis and poor prognosis after operation (right hemicolectomy) was performed in spite of receiving chemotherapy.
  • Pathologically, the germ cell tumor was composed of a yolk sac tumor and choriocarcinoma.
  • Further, all the metastatic lesions showed a germ cell phenotype.
  • An extragonadal germ cell tumor is extremely rare.
  • Our present report will contribute to the understanding of the characteristics of this rare neoplasm.
  • [MeSH-major] Adenocarcinoma / pathology. Colonic Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology
  • [MeSH-minor] Choriocarcinoma / pathology. Endodermal Sinus Tumor / pathology. Humans. Male. Middle Aged

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  • (PMID = 19967492.001).
  • [ISSN] 1437-7772
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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42. Ebisawa S, Yamazaki S, Yasuo M, Urushihata K, Tsushima K, Hanaoka M, Koizumi T, Fujimoto K, Kubo K: [Multiple hepatic metastases due to germ cell tumor on initial clinical presentation]. Nihon Kokyuki Gakkai Zasshi; 2007 Apr;45(4):318-23
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  • [Title] [Multiple hepatic metastases due to germ cell tumor on initial clinical presentation].
  • The patient was suspected to have combined germ cell tumor in the mediastinum with multiple liver metastases.
  • We report a case of germ cell tumor with multiple and diffuse hypervascular masses in the liver as the initial clinical manifestation.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Choriocarcinoma, Non-gestational / secondary. Liver Neoplasms / secondary. Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / secondary

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  • (PMID = 17491309.001).
  • [ISSN] 1343-3490
  • [Journal-full-title] Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
  • [ISO-abbreviation] Nihon Kokyuki Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Chorionic Gonadotropin, beta Subunit, Human; 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
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43. Allan RW, Algood CB, Shih IeM: Metastatic epithelioid trophoblastic tumor in a male patient with mixed germ-cell tumor of the testis. Am J Surg Pathol; 2009 Dec;33(12):1902-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic epithelioid trophoblastic tumor in a male patient with mixed germ-cell tumor of the testis.
  • This report describes a rare case of a concurrent epithelioid trophoblastic tumor (ETT) and a teratoma in a para-aortic lymph node from a 39-year-old male patient with the initial diagnosis of testicular malignant mixed germ-cell tumor.
  • Microscopically, the metastatic lesion contained a teratoma component and dispersed small nests of cohesive chorionic-type intermediate trophoblastic cells, closely resembling gestational ETT in female patients.
  • The diagnosis of ETT in this case was confirmed by stepwise immunohistochemistry.
  • Demonstration of ETT as one of the histologic manifestations of recurrent testicular germ-cell tumors should encourage pathologists to recognize this unique feature in assessing posttreatment mixed germ-cell neoplasm.
  • Furthermore, this case represents a unique opportunity to understand the pathobiology of trophoblastic neoplasms arising from germ-cell tumors.
  • [MeSH-major] Carcinoma, Embryonal / secondary. Choriocarcinoma, Non-gestational / secondary. Epithelioid Cells / pathology. Teratoma / secondary. Testicular Neoplasms / pathology. Trophoblastic Neoplasms / secondary

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  • (PMID = 19898219.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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44. Cicin I, Ozyilmaz F, Karagol H, Yalcin F, Uzunoglu S, Kaplan M: Massive upper gastrointestinal bleeding from pure metastatic choriocarcinoma in patient with mixed germ cell tumor with subclinical intestinal metastasis. Urology; 2009 Feb;73(2):443.e15-7
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  • [Title] Massive upper gastrointestinal bleeding from pure metastatic choriocarcinoma in patient with mixed germ cell tumor with subclinical intestinal metastasis.
  • Although testicular germ cell tumors have become curable neoplasms, a better understanding of the clinicopathologic features is needed for the rare manifestations associated with treatment failure.
  • We report a rare case of metastatic pure choriocarcinoma involving the small intestine arising from a testicular mixed germ cell tumor.
  • We propose an approach for the determination of subclinical intestinal metastases of testicular germ cell tumor; the case is discussed in light of similar reports in literature.
  • [MeSH-major] Choriocarcinoma / complications. Choriocarcinoma / secondary. Gastrointestinal Hemorrhage / etiology. Ileal Neoplasms / complications. Ileal Neoplasms / secondary. Jejunal Neoplasms / complications. Jejunal Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / complications. Neoplasms, Germ Cell and Embryonal / secondary. Neoplasms, Multiple Primary / complications. Testicular Neoplasms / complications. Testicular Neoplasms / pathology


45. Fléchon A, Rivoire M, Droz JP: Management of advanced germ-cell tumors of the testis. Nat Clin Pract Urol; 2008 May;5(5):262-76
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Management of advanced germ-cell tumors of the testis.
  • Advanced tumors of the testis are curable.
  • Standard treatment includes chemotherapy with a combination of bleomycin, etoposide and cisplatin, followed by surgical resection of residual tumor.
  • The number of cycles of chemotherapy needed depends on prognostic factors such as the primary site, histology, presence of visceral metastases, and serum levels of tumor markers.
  • After chemotherapy, resection of all residual local disease and systematic retroperitoneal dissection of bulky lymph-node disease are mandatory for patients with nonseminoma germ-cell tumors.
  • When complete resection of necrosis, teratoma and/or active germ-cell cancer has been done, no further treatment is needed.
  • Secondary malignancies are reported, as well as contralateral germ-cell tumors.
  • Owing to the complexity of treatment and the multidisciplinary approach required, patients with advanced germ-cell tumors should be managed in high-volume centers with experience of treating large numbers of patients.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / therapy. Testicular Neoplasms / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor. Humans. Lymphatic Metastasis. Male. Neoplasm Staging. Neoplasm, Residual / surgery. Prognosis. Risk Assessment

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  • (PMID = 18398406.001).
  • [ISSN] 1743-4289
  • [Journal-full-title] Nature clinical practice. Urology
  • [ISO-abbreviation] Nat Clin Pract Urol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
  • [Number-of-references] 97
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46. Carver BS, Sheinfeld J: Germ cell tumors of the testis. Ann Surg Oncol; 2005 Nov;12(11):871-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germ cell tumors of the testis.
  • The multidisciplinary approach to the management of germ cell tumors of the testis has resulted in survival rates of > 90% overall.
  • This review summarizes the principal management of germ cell tumors of the testis, highlighting the indications for surgery, controversies surrounding the integration of surgery, and alternative management strategies.
  • [MeSH-major] Germinoma. Testicular Neoplasms
  • [MeSH-minor] Biomarkers, Tumor / blood. Humans. Lymph Node Excision. Male. Neoplasm Staging. Seminoma / radiotherapy

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  • (PMID = 16184443.001).
  • [ISSN] 1068-9265
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 82
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47. Biermann K, Heukamp LC, Nettersheim D, Steger K, Zhou H, Franke FE, Guetgemann I, Sonnack V, Brehm R, Berg J, Bastian PJ, Müller SC, Wang-Eckert L, Schorle H, Büttner R: [Embryonal germ cells and germ cell tumors]. Verh Dtsch Ges Pathol; 2007;91:39-48
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  • [Title] [Embryonal germ cells and germ cell tumors].
  • [Transliterated title] Embryonale Keimzellen und Keimzelltumoren.
  • Testicular germ cell tumors comprise of group of pluripotent tumors including seminomas and nonseminomas, arise from intratubular germ cell neoplasia and originate from the primordial germ cells/ gonocytes.
  • Many well characterized markers of embryonic stem cells including CD9, PODXL and centromere-specific histone-H3-like protein CENPA are consistently expressed in TGCTs.
  • In embryonic stem cells, pluripotency and self renewal capacities are provided by a network of OCT3/4, NANOG and SOX2.
  • In testicular germ cell tumors, pluripotency genes OCT3/4 und NANOG are upregulated both, in seminomas and non-seminomas, while SOX2 is differentially upregulated in embryonal carcinomas only.
  • Similar to embryonic stem cells, most histological elements of type II GCTs are sensitive to chemotherapy and irradiation.
  • Furthermore, all invasive TGCTs show a consistent gain of the short arm of chromosome 12, as found in ES cells upon extensive in vitro culturing.
  • Moreover, the genetic constitution of testicular germ cell tumors can also be linked to characteristics of embryonic stem cells, likely related to their specific inability to repair DNA damage and their high sensitivity to apoptotic cell death.
  • In conclusion, testicular germ cell tumors represent embryonic cancers found in adults.
  • Both the seminomas and nonseminomas have their specific population of stem cells representative of the primordial germ cells/gonocytes and for embryonic stem cells, respectively.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Gene Expression Regulation, Neoplastic. Humans. Male. Neoplasm Proteins / genetics. Orchiectomy. RNA, Neoplasm / genetics. RNA, Neoplasm / isolation & purification. Seminoma / pathology

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  • (PMID = 18314594.001).
  • [ISSN] 0070-4113
  • [Journal-full-title] Verhandlungen der Deutschen Gesellschaft für Pathologie
  • [ISO-abbreviation] Verh Dtsch Ges Pathol
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Neoplasm
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48. Billmire DF: Malignant germ cell tumors in childhood. Semin Pediatr Surg; 2006 Feb;15(1):30-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant germ cell tumors in childhood.
  • Malignant germ cell tumors are a very heterogeneous group of neoplasms that have historically carried a poor prognosis.
  • A review of the cooperative studies on malignant extracranial germ cell tumors in children was performed to update the progress in treatment and outcome for this rare group of tumors.
  • The advent of platinum-based chemotherapy in the 1980s dramatically improved the prognosis for these tumors and allowed redefinition of risk groups.
  • Surgical management has evolved from an aggressive en bloc resection at diagnosis to a more tailored approach, with resection and meticulous staging for low stage tumors at diagnosis and biopsy with neoadjuvant chemotherapy for advanced stage tumors.
  • Improved surgical margins and prognosis are seen in post chemotherapy resections for high stage tumors.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / diagnosis. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Child. Female. Humans. Male. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / mortality. Mediastinal Neoplasms / therapy. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / mortality. Retroperitoneal Neoplasms / therapy. Sacrococcygeal Region. Survival Rate. Urogenital Neoplasms / diagnosis. Urogenital Neoplasms / mortality. Urogenital Neoplasms / therapy

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  • (PMID = 16458844.001).
  • [ISSN] 1055-8586
  • [Journal-full-title] Seminars in pediatric surgery
  • [ISO-abbreviation] Semin. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 35
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49. Koulouris CR, Penson RT: Ovarian stromal and germ cell tumors. Semin Oncol; 2009 Apr;36(2):126-36
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian stromal and germ cell tumors.
  • Cancers arising from the stromal and germ cell layers of the ovary are rare, heterogeneous, difficult to study, and require specialized multidisciplinary management.
  • These tumors more commonly present in younger patients and have a high cure rate.
  • They are associated with serum markers that are informative for diagnosis and surveillance.
  • Most patients with germ cell tumors require adjuvant chemotherapy with bleomycin, etoposide, and cisplatin (BEP), as well as careful surveillance.
  • The rarity of these tumors makes basic scientific advances more challenging.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal. Ovarian Neoplasms. Sex Cord-Gonadal Stromal Tumors
  • [MeSH-minor] Biomarkers, Tumor / analysis. Female. Humans. Prognosis

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  • (PMID = 19332247.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 78
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50. Forquer JA, Harkenrider M, Fakiris AJ, Timmerman RD, Cavaliere R, Henderson MA, Lo SS: Brain metastasis from non-seminomatous germ cell tumor of the testis. Expert Rev Anticancer Ther; 2007 Nov;7(11):1567-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Brain metastasis from non-seminomatous germ cell tumor of the testis.
  • The vast majority of testicular cancer cases with brain metastasis reported in the literature involve nonseminomatous germ cell tumor and this subtype will be the focus of this review.
  • This article reviews the literature of the diagnosis and management of brain metastasis from nonseminomatous germ cell tumor of the testis.
  • [MeSH-major] Brain Neoplasms / secondary. Germinoma / secondary. Testicular Neoplasms / pathology

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  • (PMID = 18020925.001).
  • [ISSN] 1744-8328
  • [Journal-full-title] Expert review of anticancer therapy
  • [ISO-abbreviation] Expert Rev Anticancer Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 59
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51. Jessberger R: New insights into germ cell tumor formation. Horm Metab Res; 2008 May;40(5):342-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] New insights into germ cell tumor formation.
  • Recent years have witnessed a number of new findings with significant implications for our understanding of the development of germ cell tumors.
  • This communication reviews some of these recent insights with an emphasis on mechanisms that may convert a germ cell into a tumor cell.
  • (1) the early origin of germ cell tumors from primordial germ cells through an aberrant mitosis-to-meiosis switch;.
  • (2) errors during meiosis, which promote tumorigenic transformation of germ cells; and (3) the role of small RNAs such as oncomirs (miRNAs) and oncopirs (piRNAs) in germ cell tumor formation.

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  • (PMID = 18491254.001).
  • [ISSN] 0018-5043
  • [Journal-full-title] Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • [ISO-abbreviation] Horm. Metab. Res.
  • [Language] ENG
  • [Grant] United States / NIGMS NIH HHS / GM / R01 GM062517; United States / NIGMS NIH HHS / GM / GM62517
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / MicroRNAs; 0 / RNA, Neoplasm
  • [Number-of-references] 49
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52. Väre P, Soini Y: Twist is inversely associated with claudins in germ cell tumors of the testis. APMIS; 2010 Sep 1;118(9):640-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Twist is inversely associated with claudins in germ cell tumors of the testis.
  • We investigated the expression of claudins 1, 3-7 and transcriptional factor twist in a set of testicular germ cell tumors.
  • The material consisted of 17 seminomas, 13 teratomas, 9 teratocarcinomas, 20 embryonal carcinomas and 9 mixed germ cell tumors.
  • As expected, all claudins were variably present in germ cell tumors with epithelial elements or differentiation, but the intensity of expression varied depending on the claudin type.
  • Mesenchymal elements in teratomatous tumors remained negative for claudins.
  • Expression of different claudins was less intense and inconsistent in other types of germ cell tumors.
  • Choriocarcinomatous elements in germ cell tumors expressed relatively strongly claudin 4 and weaker positivity for claudins 5-7, while claudins 1 and 3 were negative.
  • Germ cell tumors vary in their expression of claudins 1-7.
  • Twist expression was inversely associated with several claudins, suggesting that it takes part in the downregulation of claudins in testicular tumors.
  • [MeSH-major] Claudins / metabolism. Neoplasms, Germ Cell and Embryonal / pathology. Nuclear Proteins / metabolism. Testicular Neoplasms / pathology. Twist Transcription Factor / metabolism

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  • (PMID = 20718715.001).
  • [ISSN] 1600-0463
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CLDN1 protein, human; 0 / CLDN4 protein, human; 0 / Claudin-1; 0 / Claudin-4; 0 / Claudins; 0 / Membrane Proteins; 0 / Nuclear Proteins; 0 / TWIST1 protein, human; 0 / Twist Transcription Factor
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53. Atmaca AF, Altinova S, Canda AE, Ozcan MF, Alici S, Memis L, Balbay MD: Retroperitoneal extragonadal nonseminomatous germ cell tumor with synchronous orbital metastasis. Adv Urol; 2009;:419059

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal extragonadal nonseminomatous germ cell tumor with synchronous orbital metastasis.
  • A huge retroperitoneal tumor with a right orbital mass was detected and proved to be an extragonadal nonseminomatous germ cell tumor on biopsy.
  • BEP chemotherapy caused some regression in orbital mass however no change in retroperitoneal tumor size as well as serum tumor marker levels occurred.
  • Herein, we present a rarely seen entity of extragonadal retroperitoneal nonseminomatous germ cell tumor with synchronous orbital metastases and discuss its diagnosis and management.

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  • (PMID = 19197374.001).
  • [ISSN] 1687-6369
  • [Journal-full-title] Advances in urology
  • [ISO-abbreviation] Adv Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
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54. Iborra F, Mottet N: [Should the contralateral testis be systematically biopsied after orchidectomy for unilateral germ cell tumour of the testis?]. Prog Urol; 2005 Apr;15(2):217-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Should the contralateral testis be systematically biopsied after orchidectomy for unilateral germ cell tumour of the testis?].
  • [Transliterated title] Faut-il biopsier systématiquement le testicule controlatéral après orchidectomie pour une tumeur germinale unilatérale du testicule?
  • Intratubular neoplasia (ITN) of the testis is a precursor of germ cell tumour, apart from spermatocytic seminoma.
  • It is often detected in testicular tissue adjacent to germ cell tumours, but is less common in the contralateral testis.
  • Early diagnosis of ITN by testicular biopsy would allow earlier, conservative management.
  • [MeSH-major] Germinoma / pathology. Germinoma / surgery. Neoplasms, Multiple Primary / pathology. Orchiectomy. Testicular Neoplasms / surgery

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  • (PMID = 15999596.001).
  • [ISSN] 1166-7087
  • [Journal-full-title] Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
  • [ISO-abbreviation] Prog. Urol.
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 17
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55. Mathew RM, Vandenberghe R, Garcia-Merino A, Yamamoto T, Landolfi JC, Rosenfeld MR, Rossi JE, Thiessen B, Dropcho EJ, Dalmau J: Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis. Neurology; 2007 Mar 20;68(12):900-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis.
  • OBJECTIVE: To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications.
  • RESULTS: Among 25 patients with Ma2-encephalitis younger than 50 years, 19 had germ-cell tumors, and 6 had no evidence of cancer.
  • 1) demonstration of anti-Ma2 antibodies in association with MRI or clinical features compatible with Ma2-encephalitis, 2) life-threatening or progressive neurologic deficits, 3) age < 50 years, 4) absence of other tumors, and 5) new testicular enlargement or risk factors for germ-cell tumors, mainly cryptorchidism or ultrasound evidence of testicular microcalcifications.
  • All orchiectomy specimens showed intratubular-germ cell neoplasms unclassified type (IGCNU) and other abnormalities including microcalcifications, atrophy, fibrosis, inflammatory infiltrates, or hypospermatogenesis.
  • Ma2 was expressed by neoplastic cells in three of three patients examined.
  • CONCLUSIONS: In young men with Ma2-encephalitis, 1) the disorder should be attributed to a germ-cell neoplasm of the testis unless another Ma2-expressing tumor is found, 2) negative tumor markers, ultrasound, body CT, or PET do not exclude an intratubular germ-cell neoplasm of the testis, and 3) if no tumor is found, the presence of the five indicated criteria should prompt consideration of orchiectomy.

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  • (PMID = 17151337.001).
  • [ISSN] 1526-632X
  • [Journal-full-title] Neurology
  • [ISO-abbreviation] Neurology
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R56 CA089054; United States / NCI NIH HHS / CA / R01CA089054; United States / NCI NIH HHS / CA / R01 CA089054-05; United States / NCI NIH HHS / CA / CA089054-05; United States / NCI NIH HHS / CA / R01 CA089054
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Autoantibodies; 0 / Biomarkers, Tumor; 0 / Ma2 antigen; 0 / Nerve Tissue Proteins
  • [Other-IDs] NLM/ NIHMS24644; NLM/ PMC1909749
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56. Walsh TJ, Davies BJ, Croughan MS, Carroll PR, Turek PJ: Racial differences among boys with testicular germ cell tumors in the United States. J Urol; 2008 May;179(5):1961-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Racial differences among boys with testicular germ cell tumors in the United States.
  • PURPOSE: There are marked racial differences in the incidence of testicular germ cell tumors among United States men, with whites having 5 times the incidence of blacks and 3 times that of Asians.
  • Testicular germ cell tumors in boys are rare, and limited racial classification by cancer registries has made attempts to discern racial patterns difficult.
  • We hypothesize that recent diversification of race data by cancer registries may allow for more accurate racial classification, and that there are racial differences in the incidence of testicular germ cell tumors in prepubertal boys.
  • MATERIALS AND METHODS: We identified all cases of histologically confirmed testicular germ cell cancer in boys 0 to 14 years old between 1992 and 2004 through the Surveillance, Epidemiology and End Results Program.
  • Variables analyzed included age, tumor histology and year of diagnosis.
  • RESULTS: A total of 695 cases of testicular germ cell tumors were diagnosed among boys of all races, with an overall incidence of 6.3 per 1 million person-years.
  • Testicular germ cell tumors were 1.4-fold more likely to develop in Asian/Pacific Islanders compared to whites (RR 1.4, 95% CI 1.1 to 1.8).
  • Increased rates among Asian/Pacific Islanders were constant across all age strata, in cases of yolk sac tumor/embryonal, teratoma and seminoma, and were maintained from 1992 to 2004.
  • CONCLUSIONS: Asian/Pacific Islander boys are more likely to have testicular germ cell tumors compared to whites.
  • Similar to adults, race appears to have a significant role in the incidence of testicular germ cell tumors among prepubertal boys.
  • [MeSH-major] Continental Population Groups / statistics & numerical data. Neoplasms, Germ Cell and Embryonal / ethnology. Testicular Neoplasms / ethnology

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  • [ErratumIn] J Urol. 2008 Sep;180(3):1192-3
  • (PMID = 18355842.001).
  • [ISSN] 1527-3792
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Grant] United States / NICHD NIH HHS / HD / K12 HD053943012
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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57. Villano JL, Propp JM, Porter KR, Stewart AK, Valyi-Nagy T, Li X, Engelhard HH, McCarthy BJ: Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries. Neuro Oncol; 2008 Apr;10(2):121-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries.
  • The exact incidence of pineal germ-cell tumors is largely unknown.
  • The tumors are rare, and the number of patients with these tumors, as reported in clinical series, has been limited.
  • The goal of this study was to describe pineal germ-cell tumors in a large number of patients, using data from available brain tumor databases.
  • Three different databases were used: Surveillance, Epidemiology, and End Results (SEER) database (1973-2001); Central Brain Tumor Registry of the United States (CBTRUS; 1997-2001); and National Cancer Data Base (NCDB; 1985-2003).
  • Tumors were identified using the International Classification of Diseases for Oncology, third edition (ICD-O-3), site code C75.3, and categorized according to histology codes 9060-9085.
  • A total of 1,467 cases of malignant pineal germ-cell tumors were identified: 1,159 from NCDB, 196 from SEER, and 112 from CBTRUS.
  • All three databases showed a male predominance for pineal germ-cell tumors (>90%), and >72% of patients were Caucasian.
  • The majority of tumors (73%-86%) were germinomas, and patients with germinomas had the highest survival rate (>79% at 5 years).
  • The proportions of malignant pineal germ-cell tumors and intracranial germ-cell tumors are in range with previous studies.
  • Survival rates for malignant pineal germ-cell tumors are lower than results from recent treatment trials for intracranial germ-cell tumors, and patients that received radiation therapy in the treatment plan either with surgery or alone survived the longest.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / epidemiology. Neoplasms, Germ Cell and Embryonal / therapy. Pinealoma / epidemiology. Pinealoma / therapy. Registries

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  • (PMID = 18287340.001).
  • [ISSN] 1522-8517
  • [Journal-full-title] Neuro-oncology
  • [ISO-abbreviation] Neuro-oncology
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2613814
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58. Bryant CS, Kumar S, Shah JP, Mahdi H, Ali-Fehmi R, Munkarah AR, Deppe G, Morris RT: Racial disparities in survival among patients with germ cell tumors of the ovary--United States. Gynecol Oncol; 2009 Sep;114(3):437-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Racial disparities in survival among patients with germ cell tumors of the ovary--United States.
  • OBJECTIVE(S): To compare the survival of African American (AA) and white (W) patients with malignant germ cell tumors of the ovary (OGCT).
  • METHODS: Patients with a diagnosis of OGCT were identified from Surveillance, Epidemiology, and End Results Program (SEER) from 1988 to 2004, and were divided into African American (AA) and white (W) subgroups.
  • Histology was grouped into dysgerminoma (D), malignant teratoma (MT), and mixed germ cell tumors with pure non-dysgerminoma cell tumors (MGCT/PNDCT).
  • Advanced stage (FIGO III and IV) tumors were more prominent in AA (24% vs. 18%, p>0.05).
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / ethnology. Neoplasms, Germ Cell and Embryonal / mortality. Ovarian Neoplasms / ethnology. Ovarian Neoplasms / mortality
  • [MeSH-minor] Adolescent. Adult. African Continental Ancestry Group. European Continental Ancestry Group. Female. Health Status Disparities. Humans. Neoplasm Staging. Retrospective Studies. SEER Program. United States / epidemiology. Young Adult

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  • (PMID = 19560191.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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59. Fenner MH, Beutel G, Grünwald V: Targeted therapies for patients with germ cell tumors. Expert Opin Investig Drugs; 2008 Apr;17(4):511-22
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Targeted therapies for patients with germ cell tumors.
  • BACKGROUND: Patients with advanced germ cell tumors can be cured with cisplatin-based chemotherapy but the outcome remains unsatisfactory for patients with relapsed disease.
  • Targeted therapies have changed the standard of care for many advanced solid tumors.
  • OBJECTIVE: To identify clinically available drugs that have the potential as targeted therapies in germ cell tumors.
  • METHODS: A literature search was carried out for expression and mutation status of receptor tyrosine kinases in germ cell tumors, also a literature and clinical trial database search for completed and ongoing clinical trials with targeted therapies in germ cell tumors.
  • RESULTS/CONCLUSIONS: c-KIT is mutated in some seminomas and bilateral germ cell tumors.
  • We expect an increased use of targeted therapies in advanced germ cell tumors in the next few years.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Antineoplastic Agents / therapeutic use. Neoplasms, Germ Cell and Embryonal / drug therapy. Neovascularization, Pathologic / drug therapy. Protein Kinase Inhibitors / therapeutic use. Receptor Protein-Tyrosine Kinases / antagonists & inhibitors

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  • (PMID = 18363516.001).
  • [ISSN] 1744-7658
  • [Journal-full-title] Expert opinion on investigational drugs
  • [ISO-abbreviation] Expert Opin Investig Drugs
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antineoplastic Agents; 0 / Intercellular Signaling Peptides and Proteins; 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 119
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60. Cools M, Drop SL, Wolffenbuttel KP, Oosterhuis JW, Looijenga LH: Germ cell tumors in the intersex gonad: old paths, new directions, moving frontiers. Endocr Rev; 2006 Aug;27(5):468-84
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Germ cell tumors in the intersex gonad: old paths, new directions, moving frontiers.
  • The risk for the development of germ cell tumors is an important factor to deal with in the management of patients with disorders of sex development (DSD).
  • Recently, major progress has been made in identifying gene-products related to germ cell tumor development (testis-specific protein-Y encoded and octamer binding transcription factor 3/4) and in recognizing early changes of germ cells (maturation delay, preneoplastic lesions, and in situ neoplasia).
  • It is expected that the combination of these findings will allow for estimation of the risk for tumor development in the individual patient (high risk/intermediate risk/low risk).
  • This article reviews the recent literature regarding the prevalence of germ cell tumors in patients with DSD.
  • Some major limitations regarding this topic, including a confusing terminology referring to the different forms of intersex disorders and unclear criteria for the diagnosis of malignant germ cells at an early age (maturation delay vs. early steps in malignant transformation) are discussed.
  • Thereafter, an overview of the recent advances that have been made in our knowledge of germ cell tumor development and the correct diagnosis of early neoplastic lesions in this patient population is provided.
  • A new classification system for patients with DSD is proposed as a tool to refine our insight in the prevalence of germ cell tumors in specific diagnostic groups.
  • [MeSH-major] Disorders of Sex Development / complications. Neoplasms, Germ Cell and Embryonal / complications
  • [MeSH-minor] Biomarkers / analysis. Cross-Sectional Studies. Genotype. Germ Cells / growth & development. Humans. Models, Biological. Risk Factors

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  • (PMID = 16735607.001).
  • [ISSN] 0163-769X
  • [Journal-full-title] Endocrine reviews
  • [ISO-abbreviation] Endocr. Rev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
  • [Number-of-references] 124
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61. Lopes LF, Sonaglio V, Ribeiro KC, Schneider DT, de Camargo B: Improvement in the outcome of children with germ cell tumors. Pediatr Blood Cancer; 2008 Feb;50(2):250-3
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  • [Title] Improvement in the outcome of children with germ cell tumors.
  • PURPOSE: To describe the clinical characteristics and estimate the survival of children and adolescents with germ cell tumors treated with cisplatin-based combination chemotherapy according to three different protocols in Brazil.
  • METHODS: From 1983 to 1997, 106 patients were treated at the Hospital do Cancer, Sao Paulo for a diagnosis of germ cell tumor.
  • Important prognostic factors included stage (P < 0.001), metastatic status (P < 0.001) and surgical procedure at diagnosis (P < 0.001).
  • CONCLUSION: An improvement in the survival of children with germ cell tumors was achieved in the most recent trial (TCG-91) with a risk adapted approach incorporating only cisplatin and etoposide.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / therapy. Ovarian Neoplasms / therapy. Testicular Neoplasms / therapy

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17554793.001).
  • [ISSN] 1545-5017
  • [Journal-full-title] Pediatric blood & cancer
  • [ISO-abbreviation] Pediatr Blood Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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62. Kesler KA, Einhorn LH: Multimodality treatment of germ cell tumors of the mediastinum. Thorac Surg Clin; 2009 Feb;19(1):63-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multimodality treatment of germ cell tumors of the mediastinum.
  • Germ cell tumors originating in the anterior mediastinal compartment represent a rare but biologically interesting group of neoplasms.
  • PMNSGCT represent the most challenging group of malignant germ cell tumors and survival outcome is dependant on both successful chemotherapy and surgery to remove residual disease when feasible.
  • New chemotherapy strategies that reduce the incidence of persistent nonseminatous germ cell or non-germ cell cancer need continued investigation.
  • Although overall survival is inferior to nonseminomatous germ cell tumors of testicular origin, favorable subsets with pathologic evidence of either necrosis or teratoma have been identified.
  • An aggressive surgical approach after cisplatin-based chemotherapy can result in long-term survival, even in patients with persistent nonseminomatous germ cell or non-germ cell cancer, and is warranted in these otherwise young and healthy patients.
  • [MeSH-major] Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy
  • [MeSH-minor] Antineoplastic Agents / therapeutic use. Biomarkers, Tumor. Diagnostic Imaging. Humans. Thoracic Surgical Procedures

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  • (PMID = 19288821.001).
  • [ISSN] 1547-4127
  • [Journal-full-title] Thoracic surgery clinics
  • [ISO-abbreviation] Thorac Surg Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Biomarkers, Tumor
  • [Number-of-references] 24
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63. Ergunay K, Tezel GG, Dogan AI, Ozen H, Sirin G, Ozbay M, Karabulut E, Ustacelebi S: Testicular persistence of Parvovirus B19: evidence for preferential infection of germ cell tumors. Pathol Res Pract; 2008;204(9):649-53
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Testicular persistence of Parvovirus B19: evidence for preferential infection of germ cell tumors.
  • Human Parvovirus B19 has previously been implicated in the pathogenesis of testicular germ cell tumors, but this could not have been confirmed.
  • This study was designed to investigate the testicular persistence of Parvovirus B19 and possible associations with germ cell tumors.
  • Paraffin-embedded or fresh tissues from 36 germ cell tumors, 20 germ cell aplasias, 26 normal testicular tissues, 20 liver tissues, and 20 spleen tissues were evaluated by two different molecular assays: a nested PCR for Parvovirus B19 capsid genes and a commercial quantitative real-time PCR.
  • Viral DNA was detected in 3 of 36 (8.3%) germ cell tumors, but not in other groups.
  • These results either directly or indirectly imply the involvement of Parvovirus B19 with testicular germ cell tumors.
  • Viral persistence in normal testis, germ cell aplasia tissues, or hepatic/splenic tissues was not observed in this study.
  • [MeSH-major] DNA, Viral / analysis. Neoplasms, Germ Cell and Embryonal / virology. Parvovirus B19, Human. Testicular Neoplasms / virology

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  • (PMID = 18539403.001).
  • [ISSN] 0344-0338
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / DNA, Viral
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64. Feres GA, Salluh JI, Ferreira CG, Soares M: Severe acute tumor lysis syndrome in patients with germ-cell tumors. Indian J Urol; 2008 Oct;24(4):555-7

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Severe acute tumor lysis syndrome in patients with germ-cell tumors.
  • Germ-cell tumors are a high-proliferative type of cancer that may evolve to significant bulky disease.
  • Tumor lysis syndrome is rarely reported in this setting.
  • The reports of three patients with germ-cell tumors who developed severe acute tumor lysis syndrome following the start of their anticancer therapy are presented.
  • Patients with extensive germ-cell tumors should be kept on close clinical and laboratory monitoring.

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  • [Cites] Cancer Chemother Pharmacol. 2003 Mar;51(3):187-92 [12655435.001]
  • [Cites] Support Care Cancer. 2001 Oct;9(7):554-7 [11680837.001]
  • [Cites] South Med J. 2000 Sep;93(9):916-9 [11005356.001]
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  • (PMID = 19468517.001).
  • [ISSN] 0970-1591
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2684391
  • [Keywords] NOTNLM ; Acute renal failure / germ-cell tumors / tumor lysis syndrome
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65. Rondinelli PI, Osório CA, Lopes LF: [Primary intracranial germ cell tumors in children: evaluation of fourteen cases]. Arq Neuropsiquiatr; 2005 Sep;63(3B):832-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Primary intracranial germ cell tumors in children: evaluation of fourteen cases].
  • [Transliterated title] Tumores de células germinativas intracranianos na infância: avaliação de 14 casos.
  • This study evaluates the diagnosis, therapy and survival of 14 patients with primary intracranial germ cell tumors during the period from 1991 to 2001.
  • The tumor was in pineal and hypothalamic region in 10 cases, suprasellar in 3 cases, and in the cerebral parenchyma in 1 case.
  • Histologically there were 1 embryonal carcinoma, 5 germinomas, 2 mature teratomas, 1 immature teratoma and 5 mixed germ cell tumors.
  • Treatment differed among the patients according to the type of tumor.
  • Three patients died after tumor progression or relapse and one patient died from another condition.
  • [MeSH-major] Brain Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / pathology

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  • (PMID = 16258665.001).
  • [ISSN] 0004-282X
  • [Journal-full-title] Arquivos de neuro-psiquiatria
  • [ISO-abbreviation] Arq Neuropsiquiatr
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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66. Morelli F, Tozzi L, Setola P, Bisceglia M, Barbini VR, Maiello E: Postchemotherapy residual masses in germ cell tumor patients: our experience. Ann Oncol; 2006 Jun;17 Suppl 7:vii132-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Postchemotherapy residual masses in germ cell tumor patients: our experience.
  • BACKGROUND: The nature of post-chemotherapy tumor residuals can be determined only by excision and histological examination, but at present no consensus has been reached as to whether all patients with residual masses should undergo adjunctive surgery.
  • PATIENTS AND METHODS: Between August 1991 and September 2004, 120 patients with metastatic germ cell tumors were diagnosed at our hospital and 35 of these patients (30%) underwent adjunctive surgery after cisplatin-based chemotherapy.
  • If serum tumor markers were still raised salvage chemotherapy was administered.
  • Necrosis, differentiated teratoma and undifferentiated tumor were found in nine (30%), 19 (63%) and two (7%) of all patients.
  • Four of the 35 patients died as a result of their malignant germ cell tumor.
  • The median observation time after the initial diagnosis was 99 months (range 15-172 months).

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  • (PMID = 16760276.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin
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67. von Eyben FE, Jacobsen GK, Skotheim RI: Microinvasive germ cell tumor of the testis. Virchows Arch; 2005 Sep;447(3):610-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Microinvasive germ cell tumor of the testis.
  • Microinvasive germ cell tumor (MGCT) consists of a limited number of malignant germ cells in the intertubular tissue of the testis.
  • The cells have large nuclei, prominent nucleoli, abundant clear cytoplasm, and distinct cellular borders in hematoxylin and eosin staining.
  • MGCT can be the first stage of malignancy in the development of testicular germ cell tumor (TGCT).
  • Biopsies from men with maldescended testes have been reported to contain intratubular germ cell neoplasia, unclassified (IGCN) and MGCT in 1.8% of the examined cases (95% CI 0.5-4.6%).
  • Men with a high risk of TGCT may gain from screening for precursor lesions of TGCT with ultrasonography of the testes followed by a testicular biopsy if suspicious abnormalities are found: Treatment is high-voltage radiotherapy for intratubular germ cell neoplasia (IGCN), and orchidectomy for MGCT and germ cell tumor in situ, either intratubular seminoma or intratubular embryonal carcinoma.
  • The mRNA levels of invasion-related genes were evaluated based on a DNA microarray data set, and we found two gene abnormalities most relevant for the invasion of malignant germ cells: matrix metalloproteinase 9 (MMP9) and plasminogen activator, urokinase (PLAU) genes were up-regulated in a study comparing tissue samples of TGCT and IGCN.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal. Precancerous Conditions. Testicular Neoplasms

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  • (PMID = 15968545.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 198
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68. Aguirre D, Nieto K, Lazos M, Peña YR, Palma I, Kofman-Alfaro S, Queipo G: Extragonadal germ cell tumors are often associated with Klinefelter syndrome. Hum Pathol; 2006 Apr;37(4):477-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extragonadal germ cell tumors are often associated with Klinefelter syndrome.
  • Klinefelter syndrome is a well documented abnormality of sex differentiation, with an incidence of 1 in 600 newborn males.
  • Different malignancies such as breast cancer, testicular tumors, leukemia, and lymphomas occur in 1%-2% of the cases.
  • Klinefelter syndrome has been associated with other malignancies such as extragonadal germ cell tumors; however, some authors consider this association an unusual finding.
  • We report the molecular cytogenetic studies performed in 4 young males with mediastinal germ cell tumors.
  • [MeSH-major] Germinoma / pathology. Klinefelter Syndrome / pathology. Mediastinal Neoplasms / pathology. Teratoma / pathology

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  • (PMID = 16564924.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Karkhanis V, Joshi JM: Nonseminomatous germ cell tumor with seizure disorder and mental retardation. Lung India; 2009 Oct;26(4):139-41

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nonseminomatous germ cell tumor with seizure disorder and mental retardation.
  • We report a case of a patient who presented with anterior mediastinal mass, seizure disorder, and mental retardation.
  • Computerized tomography-guided fine-needle aspiration biopsy of the mass showed nonseminomatous germ cell tumor.
  • A diagnosis of Klinefelter syndrome and mediastinal germ cell tumor was made.

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  • [Cites] Ann Oncol. 2007 May;18(5):917-24 [17351252.001]
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  • (PMID = 20531999.001).
  • [ISSN] 0974-598X
  • [Journal-full-title] Lung India : official organ of Indian Chest Society
  • [ISO-abbreviation] Lung India
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2876702
  • [Keywords] NOTNLM ; Klinefelter syndrome / Mediastinal germ cell tumors / nonseminomatous germ cell tumor
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70. Elizondo ZA, Montelongo MR, González JE: [Extragonadal germ cell tumor in mediastinum: case report]. Actas Urol Esp; 2008 Mar;32(3):357-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Extragonadal germ cell tumor in mediastinum: case report].
  • [Transliterated title] Tumor extragonadal de células germinales en mediastino: aportación de un caso.
  • The Germ Cell tumors of extragonadal origin are infrequent cases being described in literature less than 1000 cases.
  • In the image studies a mediastinal mass was demonstrated, a biopsy was taken arriving at the diagnosis.
  • Normal tumor markers, testicular ultrasonography reported the presence of bilateral microlitiasis.
  • [MeSH-major] Mediastinal Neoplasms. Neoplasms, Germ Cell and Embryonal

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  • (PMID = 18512396.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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71. Lertkhachonsuk R, Termrungruanglert W, Vasuratna A, Sittisomwong T, Worasethsin P, Tresukosol D: Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital. J Med Assoc Thai; 2005 Sep;88 Suppl 4:S124-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital.
  • OBJECTIVES: To determine the frequency, characteristics, treatment and outcome of patients with malignant ovarian germ cell tumor (MOGCT) in King Chulalongkorn Memorial Hospital during the period January 1992 - December 2000.
  • STUDY DESIGN: Retrospective descriptive study MATERIAL AND METHOD: All patients with malignant ovarian germ cell tumor in King Chulalongkorn Memorial Hospital during the period January 1992 - December 2000 were analyzed by the characteristics of patients, treatment and outcome.
  • CONCLUSION: MOGCT in King Chulalongkorn Memorial Hospital had clinical characteristics similar to other studies in malignant ovarian germ cell tumor Treatment by VAC regimen still has benefit in selected group.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Ovarian Neoplasms / surgery. Treatment Outcome

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  • (PMID = 16623016.001).
  • [ISSN] 0125-2208
  • [Journal-full-title] Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • [ISO-abbreviation] J Med Assoc Thai
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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72. Hoei-Hansen CE, Sommer P, Rajpert-De Meyts E, Skakkebaek NE: A rare diagnosis: testicular dysgenesis with carcinoma in situ detected in a patient with ultrasonic microlithiasis. Asian J Androl; 2005 Dec;7(4):445-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare diagnosis: testicular dysgenesis with carcinoma in situ detected in a patient with ultrasonic microlithiasis.
  • A rare case is presented where a dysgenetic testis with microinvasive carcinoma in situ (CIS, also known as intratubular germ cell neoplasm of unclassified type [IGCNU] and testicular intraepithelial neoplasia [TIN]) with microinvasion to rete testis and the interstitial tissue was found in a 32-year-old man presenting with mild scrotal pain and ultrasonic testicular microlithiasis.
  • Knowledge of the association of ultrasound and CIS is important to diagnose patients at the stage prior to development of an overt germ cell tumor.
  • [MeSH-major] Carcinoma in Situ / complications. Carcinoma in Situ / ultrasonography. Testicular Neoplasms / complications. Testicular Neoplasms / ultrasonography. Testis / abnormalities

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  • (PMID = 16281095.001).
  • [ISSN] 1008-682X
  • [Journal-full-title] Asian journal of andrology
  • [ISO-abbreviation] Asian J. Androl.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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73. Zhu R, Bhattacharya C, Matin A: The role of dead-end in germ-cell tumor development. Ann N Y Acad Sci; 2007 Dec;1120:181-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The role of dead-end in germ-cell tumor development.
  • Testicular germ-cell tumors occur in human males of all age groups, from infants to men over 50 years old.
  • Most commonly, germ-cell tumors (generally known as testicular cancer) occur in young males between the ages of 15 to 35 years.
  • The tumor tissues are usually histologically diverse, and testicular tumors that occur in the different age groups tend to be of specific histological subtypes.
  • Most germ-cell tumors originate from primordial germ cells during embryonic development, although the progression and eventual detection of the disease occurs decades later in humans.
  • Mouse strains spontaneously develop a specific subtype of testicular germ-cell tumors, the type I germ-cell tumors, and these tumors are similar to the germ-cell tumors (or teratomas) that occur in human infants.
  • Some mouse strains, such as the 129-Ter strain, have extremely high germ-cell tumor incidences, making such strains ideal for genetic and biological studies of germ cell-tumor development.
  • Here a brief overview of the recently identified genetic defect in the Ter strain, inactivation of the dead-end (Dnd1) gene, and the ongoing studies on Dnd1 to understand its role in germ-cell and germ cell-tumor development, are provided.

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  • (PMID = 17905939.001).
  • [ISSN] 0077-8923
  • [Journal-full-title] Annals of the New York Academy of Sciences
  • [ISO-abbreviation] Ann. N. Y. Acad. Sci.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA093754-05; United States / NCI NIH HHS / CA / R01 CA093754; United States / NCI NIH HHS / CA / R01 CA093754-05; United States / NCI NIH HHS / CA / R01CA93754
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Dnd1 protein, mouse; 0 / Neoplasm Proteins
  • [Number-of-references] 26
  • [Other-IDs] NLM/ NIHMS61387; NLM/ PMC2518318
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74. Devi M, Leonard N, Silverman S, Al-Qahtani M, Girgis R: Testicular mixed germ cell tumor in an adolescent with cowden disease. Oncology; 2007;72(3-4):194-6
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  • [Title] Testicular mixed germ cell tumor in an adolescent with cowden disease.
  • Cowden disease (also known as Cowden syndrome) is characterized by multiple organ hamartomatous tumors and an increased risk of malignancy, in particular of the breast, thyroid and endometrium.
  • Testicular tumors including seminoma have previously been reported in adult patients.
  • We are reporting, for the first time, a case of testicular mixed germ cell tumor in an adolescent with Cowden disease.
  • An association of testicular malignancy in Cowden disease could be explained by the previous observation of strong PTEN gene expression in the basal cell layer around seminiferous tubules and increased frequency of PTEN mutations in cultured testicular cancer cell lines.
  • [MeSH-major] Hamartoma Syndrome, Multiple / complications. Neoplasms, Germ Cell and Embryonal / pathology. Testicular Neoplasms / pathology

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  • [Copyright] (c) 2007 S. Karger AG, Basel
  • (PMID = 18160807.001).
  • [ISSN] 1423-0232
  • [Journal-full-title] Oncology
  • [ISO-abbreviation] Oncology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 3.1.3.67 / PTEN Phosphohydrolase
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75. Radaideh SM, Cook VC, Kesler KA, Einhorn LH: Outcome following resection for patients with primary mediastinal nonseminomatous germ-cell tumors and rising serum tumor markers post-chemotherapy. Ann Oncol; 2010 Apr;21(4):804-7
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  • [Title] Outcome following resection for patients with primary mediastinal nonseminomatous germ-cell tumors and rising serum tumor markers post-chemotherapy.
  • BACKGROUND: To assess the outcome of surgical resection in patients with primary mediastinal nonseminomatous germ-cell tumors (PMNSGCT) with rising serum tumor markers (STM) following standard platinum-based chemotherapy.
  • Twenty-four of the 35 (69%) pathologically demonstrated viable germ-cell tumor, while 8 patients had teratoma and 3 patients had necrosis only at time of resection, despite the presence of rising STM.
  • Twenty-seven patients normalized their tumor markers postoperatively.

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  • (PMID = 19889611.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Pharmacological; 0 / Biomarkers, Tumor
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76. Hammond S, Zhu R, Youngren KK, Lam J, Anderson P, Matin A: Chromosome X modulates incidence of testicular germ cell tumors in Ter mice. Mamm Genome; 2007 Dec;18(12):832-8
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  • [Title] Chromosome X modulates incidence of testicular germ cell tumors in Ter mice.
  • Germ cell tumor development in humans has been proposed to be part of testicular dysgenesis syndrome (TDS), which manifests as undescended testes, sterility, hypospadias, and, in extreme cases, as germ cell tumors.
  • Males of the Ter mouse strain show interesting parallels to TDS because they either lack germ cells and are sterile or develop testicular germ cell tumors.
  • Here we report that chromosome X modulates germ cell tumor development in Ter mice.
  • We tested whether the X or the Y chromosome influences tumor incidence.
  • We found that Ter/Ter males with B6-Chr X, but not B6-Chr Y, showed a significant shift in propensity from testicular tumor development to sterile testes phenotype.
  • Thus, our studies provide unambiguous evidence that genetic factors from Chr X modulate the incidence of germ cell tumors in mice with inactivated Dnd1.

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  • (PMID = 18049836.001).
  • [ISSN] 0938-8990
  • [Journal-full-title] Mammalian genome : official journal of the International Mammalian Genome Society
  • [ISO-abbreviation] Mamm. Genome
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA075056; United States / NCI NIH HHS / CA / R01 CA075056-06; United States / NCI NIH HHS / CA / CA075056-03; United States / NCI NIH HHS / CA / R01 CA075056-03; United States / NCI NIH HHS / CA / CA93754; United States / NCI NIH HHS / CA / CA75056; United States / NCI NIH HHS / CA / CA075056-04; United States / NCI NIH HHS / CA / CA075056-02; United States / NCI NIH HHS / CA / CA075056-06; United States / NCI NIH HHS / CA / R01 CA093754; United States / NCI NIH HHS / CA / CA093754-04; United States / NCI NIH HHS / CA / R01 CA075056-02; United States / NCI NIH HHS / CA / CA075056-05; United States / NCI NIH HHS / CA / R01 CA075056-05; United States / NCI NIH HHS / CA / R01 CA075056-04; United States / NCI NIH HHS / CA / R01 CA093754-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Other-IDs] NLM/ NIHMS61385; NLM/ PMC2647741
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77. Amin RM, Kokubo T, Hiroshima K, Narita M, Itou K, Kuroki M, Tanizawa T, Nakatani Y: Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma. Pathol Int; 2005 Oct;55(10):649-54
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Metastatic germ cell tumor of the lung masquerading as primary rhabdomyosarcoma.
  • Two years after testicular resection was carried out in a 40-year-old man that revealed mixed germ cell tumor of more than one histological type (seminoma, embryonal cell carcinoma, and yolk sac tumor), he presented with an asymptomatic pulmonary nodule in his left lower lobe.
  • Video-assisted thoracoscopic partial resection of the tumor revealed a 24 x 20 mm teratoma with somatic-type malignancy in which pleomorphic rhabdomyosarcoma was a major element.
  • One year later, asymptomatic tumor recurrence occurred at both edges of the stapler line as 22 x 20 mm and 10 x 5 mm nodules composed only of pleomorphic rhabdomyosarcoma.
  • Throughout the course there was no abdominal lymph node swelling detected by computed tomography (CT) and tumor markers were normal.
  • Adjuvant chemotherapy was started after the tumor recurrence.
  • Currently, the patient is still undergoing chemotherapy 5 months after the tumor recurrence.
  • In conclusion, despite the fact that primary pulmonary rhabdromyosarcoma is a rare neoplasm, metastatic pulmonary germ cell tumor with somatic-type malignancy showing predominantly rhabdomyosarcomatous differentiation should be considered in the differential diagnosis of such lesions of the lung.
  • [MeSH-major] Lung Neoplasms / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Rhabdomyosarcoma / diagnosis. Testicular Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Chemotherapy, Adjuvant. Combined Modality Therapy. Diagnosis, Differential. Humans. Immunoenzyme Techniques. Male. Neoplasm Recurrence, Local. Tomography, X-Ray Computed

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  • (PMID = 16185296.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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78. Willis SN, Mallozzi SS, Rodig SJ, Cronk KM, McArdel SL, Caron T, Pinkus GS, Lovato L, Shampain KL, Anderson DE, Anderson RC, Bruce JN, O'Connor KC: The microenvironment of germ cell tumors harbors a prominent antigen-driven humoral response. J Immunol; 2009 Mar 1;182(5):3310-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The microenvironment of germ cell tumors harbors a prominent antigen-driven humoral response.
  • Germ cell tumors are a heterogeneous group of neoplasms derived from residual primordial tissue.
  • These tumors are commonly found in the brain, testes, or ovaries, where they are termed germinomas, seminomas, or dysgerminomas, respectively.
  • Like several other tumor types, germ cell tumors often harbor an immune cell infiltrate that can include substantial numbers of B cells.
  • Yet little is known about whether the humoral immune response affects germ cell tumor biology.
  • To gain a deeper understanding of the role B cells play in this tumor family, we characterized the immune cell infiltrate of all three germ cell tumor subtypes and defined the molecular characteristics of the B cell Ag receptor expressed by tumor-associated B cells.
  • Immunohistochemistry revealed a prominent B cell infiltrate in the microenvironment of all tumors examined and clear evidence of extranodal lymphoid follicles with germinal center-like architecture in a subset of specimens.
  • Molecular characterization of the Ig variable region from 320 sequences expressed by germ cell tumor-infiltrating B cells revealed clear evidence of Ag experience, in that the cardinal features of an Ag-driven B cell response were present: significant somatic mutation, isotype switching, and codon insertion/deletion.
  • This characterization also revealed the presence of both B cell clonal expansion and variation, suggesting that local B cell maturation most likely occurs within the tumor microenvironment.
  • Collectively, these data strongly suggest that an adaptive and specific humoral immune response is occurring within the tumor microenvironment.
  • [MeSH-major] Antibodies, Neoplasm / biosynthesis. Antigens, Neoplasm / immunology. Neoplasms, Germ Cell and Embryonal / immunology. Neoplasms, Germ Cell and Embryonal / metabolism
  • [MeSH-minor] B-Lymphocyte Subsets / immunology. B-Lymphocyte Subsets / metabolism. B-Lymphocyte Subsets / pathology. Cell Movement / immunology. Clone Cells. Dysgerminoma / immunology. Dysgerminoma / metabolism. Dysgerminoma / pathology. Germinoma / immunology. Germinoma / metabolism. Germinoma / pathology. Humans. Immunoglobulin Heavy Chains / biosynthesis. Immunoglobulin Heavy Chains / genetics. Immunoglobulin Variable Region / biosynthesis. Immunoglobulin Variable Region / genetics. Medulloblastoma / immunology. Medulloblastoma / metabolism. Medulloblastoma / pathology. Molecular Sequence Data. Seminoma / immunology. Seminoma / metabolism. Seminoma / pathology. T-Lymphocyte Subsets / immunology. T-Lymphocyte Subsets / metabolism. T-Lymphocyte Subsets / pathology

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  • (PMID = 19234230.001).
  • [ISSN] 1550-6606
  • [Journal-full-title] Journal of immunology (Baltimore, Md. : 1950)
  • [ISO-abbreviation] J. Immunol.
  • [Language] eng
  • [Databank-accession-numbers] GENBANK/ FJ604240/ FJ604241/ FJ604242/ FJ604243/ FJ604244/ FJ604245
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Neoplasm; 0 / Antigens, Neoplasm; 0 / Immunoglobulin Heavy Chains; 0 / Immunoglobulin Variable Region
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79. Toller CA, Rustin GJ: Novel presentation of retroperitoneal germ cell tumor with loss of ejaculation but preservation of erection in two patients. Fertil Steril; 2005 Dec;84(6):1744
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  • [Title] Novel presentation of retroperitoneal germ cell tumor with loss of ejaculation but preservation of erection in two patients.
  • OBJECTIVE: To examine the effect of large-volume retroperitoneal germ cell tumor on nerve fibers required for erection and ejaculation.
  • Large-volume tumors would encase the sympathetic plexuses at L1 to L3, making ejaculation impossible.
  • Presentation with these symptoms requires further investigation at an early stage to exclude retroperitoneal tumor.
  • [MeSH-major] Ejaculation. Neoplasms, Germ Cell and Embryonal / diagnosis. Penile Erection. Retroperitoneal Neoplasms / diagnosis. Sexual Dysfunction, Physiological / diagnosis

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  • (PMID = 16359977.001).
  • [ISSN] 1556-5653
  • [Journal-full-title] Fertility and sterility
  • [ISO-abbreviation] Fertil. Steril.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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80. Villalobos Gollás M, Negrete Pulido O, Mendez Probst C, Fuentes Corona R, Sotomayor de Zavaleta M, Feria Bernal G: [Importance of microlithiasis in testicular germ cell tumor ultrasound]. Actas Urol Esp; 2008 Feb;32(2):190-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Importance of microlithiasis in testicular germ cell tumor ultrasound].
  • [Transliterated title] Importancia de microlitiasis en ultrasonido de neoplasias de células germinales de testículo.
  • We analyzed the ultrasounds of patients with testicular germ cell tumors in order to analyze the correlation between TM, histological findings and clinical variables.
  • METHODS AND MATERIALS: Fifty-seven patients with germ cell tumors and radical orchiectomy were included.
  • Patients with TM had a greater likelihood of nonseminomatous germ cell tumors (NSGCT) vs seminomatous (55.6% vs 30%, p=0.05), stage II/III testicular cancer (51.8% vs 16.7%, p=0.005), positive surgical margins (18.5% vs 0%, p=0.021), and spermatic cord invasion (14.8% vs 0%, p=0.048).
  • CONCLUSION: This study showed that TM in testicular tumors is associated to NSGCT, advanced clinical stage, positive surgical margins, and spermatic cord invasion.
  • [MeSH-major] Lithiasis / complications. Lithiasis / ultrasonography. Neoplasms, Germ Cell and Embryonal / complications. Neoplasms, Germ Cell and Embryonal / ultrasonography. Testicular Diseases / complications. Testicular Diseases / ultrasonography. Testicular Neoplasms / complications. Testicular Neoplasms / ultrasonography

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  • (PMID = 18409468.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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81. Madden J, Foreman NK, Liu AK: Germ cell tumors of the brainstem: report on two cases with pulmonary complications and a review of the literature. J Neurooncol; 2009 Jul;93(3):405-8
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  • [Title] Germ cell tumors of the brainstem: report on two cases with pulmonary complications and a review of the literature.
  • Intracranial germ cell tumors most commonly present in the pineal and suprasellar regions.
  • Rare cases of brainstem germ cell tumors have been described.
  • Here, we present two cases with brainstem germ cell tumors and review the current literature.
  • [MeSH-major] Brain Stem Neoplasms / complications. Brain Stem Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / complications. Neoplasms, Germ Cell and Embryonal / pathology. Respiratory Insufficiency / etiology

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  • (PMID = 19139823.001).
  • [ISSN] 1573-7373
  • [Journal-full-title] Journal of neuro-oncology
  • [ISO-abbreviation] J. Neurooncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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82. Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL: [Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]. Zhonghua Bing Li Xue Za Zhi; 2005 Nov;34(11):711-5

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors].
  • OBJECTIVE: To study the immunohistochemical expression of OCT4, CD117 and CD30 in germ cell tumors and to assess their diagnostic value.
  • METHODS: Immunohistochemical study for OCT4 was performed on formalin-fixed, paraffin-embedded tissues of 63 cases of germ cell tumors, including seminoma (21), dysgerminoma (7), germinoma (8), embryonal carcinoma (8), yolk sac tumor (6), mature teratoma (10) and immature teratoma (3), as well as 25 cases of non-germ cell tumors, including granulosa cell tumor (8), clear cell adenocarcinoma (4), Leydig's cell tumor (5), diffuse large B-cell lymphoma (4) and malignant melanoma (4).
  • Besides, the expression of CD117 and CD30 in all germ cell tumors was studied.
  • All other germ cell tumors and non-germ cell tumors were negative for OCT4, except for 1 case of yolk sac tumor and 1 case of clear cell adenocarcinoma which showed weak staining.
  • Focal weak membranous staining was also noted in 1 case of yolk sac tumor.
  • One case of germinoma and 1 case of yolk sac tumor showed weak cytoplasmic positivity.
  • [MeSH-major] Antigens, CD30 / metabolism. Neoplasms, Germ Cell and Embryonal / metabolism. Octamer Transcription Factor-3 / metabolism. Proto-Oncogene Proteins c-kit / metabolism
  • [MeSH-minor] Carcinoma, Embryonal / metabolism. Carcinoma, Embryonal / pathology. Diagnosis, Differential. Dysgerminoma / metabolism. Dysgerminoma / pathology. Endodermal Sinus Tumor / metabolism. Endodermal Sinus Tumor / pathology. Female. Germinoma / metabolism. Germinoma / pathology. Humans. Male. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Seminoma / metabolism. Seminoma / pathology. Teratoma / metabolism. Teratoma / pathology. Testicular Neoplasms / metabolism. Testicular Neoplasms / pathology

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  • (PMID = 16536313.001).
  • [ISSN] 0529-5807
  • [Journal-full-title] Zhonghua bing li xue za zhi = Chinese journal of pathology
  • [ISO-abbreviation] Zhonghua Bing Li Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antigens, CD30; 0 / Octamer Transcription Factor-3; 0 / Pou5f1 protein, mouse; EC 2.7.10.1 / Proto-Oncogene Proteins c-kit
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83. Tummala MK, Hussain A: Recent developments in germ cell tumors of the testes. Curr Opin Oncol; 2008 May;20(3):287-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recent developments in germ cell tumors of the testes.
  • PURPOSE OF REVIEW: An overview on several important developments in testicular germ cell tumors in the past year is provided.
  • RECENT FINDINGS: Despite being highly treatable even in advanced stages, recent studies demonstrate that testicular germ cell tumor mortalities can vary significantly in different regions of the world, suggesting limited access to appropriate treatments in certain geographic regions.
  • Large databases on testicular cancer survivors were analyzed to further define potentially delayed toxicities of initial treatments for testicular germ cell tumors.
  • SUMMARY: Significant challenges for poor-risk germ cell tumors remain.
  • Treatment paradigms and follow-up strategies for the different stages of testicular germ cell tumors continue to be defined and refined, as research in these areas continues.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Neoplasms, Germ Cell and Embryonal / drug therapy. Testicular Neoplasms / drug therapy
  • [MeSH-minor] Biomarkers, Tumor / analysis. Cisplatin / administration & dosage. Etoposide / administration & dosage. Humans. Lymph Node Excision. Lymph Nodes / surgery. Male. Prognosis. Retroperitoneal Space. Risk Factors. Seminoma / drug therapy

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  • (PMID = 18391628.001).
  • [ISSN] 1531-703X
  • [Journal-full-title] Current opinion in oncology
  • [ISO-abbreviation] Curr Opin Oncol
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 6PLQ3CP4P3 / Etoposide; Q20Q21Q62J / Cisplatin
  • [Number-of-references] 34
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84. Park DS, Chung MK, Chung JI, Ahn HJ, Lee ES, Choi HY, Yoon DK, Cheon J, Hong SJ, Lee YG, Yoon SM, Kim WJ, Kim HJ, Ryu SB, Ro JY: Histologic type, staging, and distribution of germ cell tumors in Korean adults. Urol Oncol; 2008 Nov-Dec;26(6):590-4
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  • [Title] Histologic type, staging, and distribution of germ cell tumors in Korean adults.
  • OBJECTIVES: To investigate the presentation of germ cell tumors (GCT) in terms of histology and stage, to better clarify the epidemiology of this disease in eastern Asia.
  • Clinical parameters at the time of initial diagnosis were classified in terms of the American Joint Committee on Cancer (AJCC) tumor, nodes, metastasis staging (TNMS) system, the International Germ Cell Cancer Collaborative Classification (IGCCC), for high-risk stage I nonseminomatous GCT (NSGCT) of testis.
  • RESULTS: The anatomic distributions for the primary sites of the observed tumors were as follows: testis 471 cases (67%); central nervous system (CNS) 137 cases (20%); mediastinum 78 cases (11%), and retroperitoneum 12 cases (2%); 239 (51%) of 471 tumors with testicular primary were seminoma.
  • Of NSGCT of testis, 129 (58%), 73 (33%), and 21 (9%) of tumors presented with good, intermediate, and poor prognosis, respectively, based on IGCCC, whereas 231 (99%) patients were classified with a good prognosis and 3 (1%) with an intermediate prognosis amongst seminomas of testis; 193 (82%) cases presented as stage I testicular seminoma whereas 120 (54%) cases presented as stage I NSGCT.
  • NSGCT presents itself as a more aggressive form whereas seminoma is a very indolent tumor when compared with cases in Western countries.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / pathology. Testicular Neoplasms / pathology
  • [MeSH-minor] Adult. Humans. Korea / epidemiology. Male. Neoplasm Staging. Prognosis

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  • (PMID = 18367106.001).
  • [ISSN] 1078-1439
  • [Journal-full-title] Urologic oncology
  • [ISO-abbreviation] Urol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Cheng MF, Peng YJ, Huang GS, Lee CH, Chiang PC, Lee HS: Unusual scapular metastasis as initial manifestation of advanced nonseminomatous germ cell tumor of the mediastinum. Heart Lung; 2007 Jan-Feb;36(1):79-84
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  • [Title] Unusual scapular metastasis as initial manifestation of advanced nonseminomatous germ cell tumor of the mediastinum.
  • Primary malignant germ cell tumors of the mediastinum are relatively rare, occurring predominantly in young male adults, and have a poor prognosis.
  • We present a case of a 27-year-old man who initially experienced a persistent, intractable painful sensation over the right lower scapula despite taking an analgesic agent for 2 months.
  • Excisional biopsy of the scapula revealed a metastatic carcinoma, suggestive of nonseminomatous germ cell tumor origin.
  • Chest computed tomography and magnetic resonance imaging showed a primary tumor mass in the anterior mediastinum.
  • The mediastinal tumor mass was markedly reduced in size and remission without evidence of tracer uptake by [(18)F]fluorodeoxyglucose positron emission tomography examination.
  • Six months after chemotherapy, the patient received advanced surgical intervention to remove the mediastinal tumor, the pathologic features of which were similar to the previous scapular lesion.
  • [MeSH-major] Bone Neoplasms / secondary. Mediastinal Neoplasms / pathology. Neoplasms, Germ Cell and Embryonal / secondary. Scapula
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Humans. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 17234481.001).
  • [ISSN] 0147-9563
  • [Journal-full-title] Heart & lung : the journal of critical care
  • [ISO-abbreviation] Heart Lung
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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86. Dagli AF, Pehlivan S, Cihangiroglu G, Ozercan MR: Cytology of mixed germ cell tumor with mediastinal metastasis. J Cytol; 2009 Jul;26(3):120-2
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  • [Title] Cytology of mixed germ cell tumor with mediastinal metastasis.
  • Nonseminomatous germ cell tumors of the testis are common and are very aggressive malignant tumors.
  • Most of the cases have metastases at the time of diagnosis, and involvement of the posterior mediastinum in particular is well known.
  • A 33 year-old male patient presented with complaints of a swelling on the right side of the neck that had been growing for the last month, as well as shortness of breath and cough.
  • The patient, who was given the preliminary diagnosis of a mixture metastatic bronchial tumor plus lymphoma, was subjected to transthoracic fine needle aspiration cytology (FNAC).
  • The patient, who could not be typed in his cytopathological examination, was diagnosed with malignant epithelial tumor and was recommended to undergo a genitourinary system examination.
  • Histopathological examination of the orchiectomy material resulted in the diagnosis of mixed germ cell tumor (60% mature teratoma and 40% yolk sac tumor).
  • Even though metastatic lesions are mostly seen in the posterior mediastinum, our findings reveal that specimens obtained with FNAC from the anterior mediastinum bear discohesive, pleomorphic, small nuclei in epithelial cells with microvacoules in the cytoplasm.
  • These cytopathological alterations in specimens from the anterior mediastinum might promote germ cell and yolk sac tumors.

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  • (PMID = 21938171.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3168014
  • [Keywords] NOTNLM ; Nonseminomatous germ cell tumor / fine needle aspiration cytology / mixed germ cell tumor / testis
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87. Matsumoto J, Kochi M, Morioka M, Nakamura H, Makino K, Hamada J, Kuratsu J, Ushio Y: A long-term ventricular drainage for patients with germ cell tumors or medulloblastoma. Surg Neurol; 2006 Jan;65(1):74-80; discussion 80
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  • [Title] A long-term ventricular drainage for patients with germ cell tumors or medulloblastoma.
  • BACKGROUND: Hydrocephalus associated with intracranial germ cell tumors or disseminated medulloblastoma has been treated with ventriculoperitoneal shunt.
  • However, this procedure has a potential risk of intraperitoneal metastasis of these brain tumors.
  • METHODS: From 1979 to 2003, we have treated 96 patients with germ cell tumors and medulloblastoma in our hospital.
  • Of 96 patients, 59 (germ cell tumor, 31; medulloblastoma, 28) had hydrocephalus and 13 needed long-term cerebrospinal fluid drainage to manage the obstructive hydrocephalus due to persistent tumor or communicating hydrocephalus due to dissemination.
  • CONCLUSIONS: Percutaneous long-tunneled ventricular drainage was an effective method to manage long-lasting obstructive or communicating hydrocephalus with germ cell tumors and medulloblastoma.
  • [MeSH-major] Brain Neoplasms / complications. Hydrocephalus / etiology. Hydrocephalus / surgery. Medulloblastoma / complications. Neoplasms, Germ Cell and Embryonal / complications. Ventriculoperitoneal Shunt


88. Ketata H, Bouacida M, Bouhlel A, Sahnoun A, Bahloul A, Yaich S, Hachicha J, Mhiri MN: A transplant recipient with a mixed germ-cell ovarian tumor. Saudi J Kidney Dis Transpl; 2008 Nov;19(6):973-5
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  • [Title] A transplant recipient with a mixed germ-cell ovarian tumor.
  • Immunosuppressed renal transplant recipients seem to be at significantly increased risk of developing neoplasms comparatively to nonimmunosuppressed individuals.
  • We present a trans-plant recipient with a history of an ovarian mixed germ-cell tumor, with choriocarcinoma component, which was treated seven years prior to transplantation.
  • After three years of follow-up, there was no evidence of tumor relapse.
  • Regarding our case report and patients with a history of ovarian germ-cell neoplasm, waiting time before transplantation must take into consideration the stage of the tumor, its prognosis, the proportion of different tumor components, and the overall prognosis of the patient if transplantation is withheld.
  • [MeSH-major] Kidney Failure, Chronic / epidemiology. Kidney Transplantation. Neoplasms, Germ Cell and Embryonal / epidemiology. Ovarian Neoplasms / epidemiology

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  • (PMID = 18974587.001).
  • [ISSN] 1319-2442
  • [Journal-full-title] Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
  • [ISO-abbreviation] Saudi J Kidney Dis Transpl
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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89. Fitzgerald JP, Ercole B, Parekh DJ: Management of post-chemotherapy residual mass in patients with metastatic nonseminomatous germ cell tumors of the testis. Indian J Urol; 2010 Jan-Mar;26(1):98-101

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  • [Title] Management of post-chemotherapy residual mass in patients with metastatic nonseminomatous germ cell tumors of the testis.
  • The basis of treatment for advanced germ cell tumors is chemotherapy and surgical resection of residual disease.
  • Complete removal of all post-chemotherapy residual masses remains the standard of care in the treatment of advanced nonseminomatous germ cell tumors both within and outside of the retroperitoneum.

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  • (PMID = 20535294.001).
  • [ISSN] 1998-3824
  • [Journal-full-title] Indian journal of urology : IJU : journal of the Urological Society of India
  • [ISO-abbreviation] Indian J Urol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2878447
  • [Keywords] NOTNLM ; Cancer / testis
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90. Skotheim RI, Autio R, Lind GE, Kraggerud SM, Andrews PW, Monni O, Kallioniemi O, Lothe RA: Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes. Cell Oncol; 2006;28(5-6):315-26
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  • [Title] Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes.
  • INTRODUCTION: Testicular germ cell tumors of adolescent and young adult men (TGCTs) generally have near triploid and complex karyotypes.
  • We analyzed 17 TGCTs, three precursor lesions, and the embryonal carcinoma cell lines, NTERA2 and 2102Ep, by comparative genomic hybridization microarrays (array-CGH), and integrated the data with transcriptome profiles of the same samples.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 12 / genetics. Gene Expression Regulation, Neoplastic. Genome, Human / genetics. Neoplasms, Germ Cell and Embryonal / genetics. Oligonucleotide Array Sequence Analysis / methods. Testicular Neoplasms / genetics
  • [MeSH-minor] Adolescent. Adult. DNA, Neoplasm / genetics. Gene Dosage. Gene Expression Profiling. Genes, Neoplasm. Humans. Male. Nucleic Acid Hybridization. Reproducibility of Results. Up-Regulation / genetics

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  • (PMID = 17167184.001).
  • [ISSN] 1570-5870
  • [Journal-full-title] Cellular oncology : the official journal of the International Society for Cellular Oncology
  • [ISO-abbreviation] Cell. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC4615958
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91. Zhukova VA, Ageeva TA, Nadeev AP, Gorbacheva OV, Travin MA: [A case of malignant germ-cell tumor with choriocarcinoma]. Arkh Patol; 2009 Jul-Aug;71(4):55-6
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  • [Title] [A case of malignant germ-cell tumor with choriocarcinoma].
  • The authors describe a case of the malignant retroperitoneal germ-cell tumor in a 20-year-old male, which appears as several types of tissues that are derivatives of three germinal layers with the presence in its composition of choriocarcinoma, metastases of which to the vital organs were a cause of death.
  • [MeSH-major] Choriocarcinoma / secondary. Retroperitoneal Neoplasms / pathology. Teratoma / secondary
  • [MeSH-minor] Fatal Outcome. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Young Adult

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  • (PMID = 19824434.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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92. Lorch A, Oechsle K, Bokemeyer C, Beyer J: [Salvage treatment in germ cell tumors : high-dose chemotherapy and the impact of prognostic factors]. Urologe A; 2009 Apr;48(4):364-71
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  • [Title] [Salvage treatment in germ cell tumors : high-dose chemotherapy and the impact of prognostic factors].
  • The majority of patients with germ cell tumors who fail first-line treatment will still be cured.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / surgery. Orchiectomy / methods. Salvage Therapy / methods. Testicular Neoplasms / drug therapy. Testicular Neoplasms / surgery

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  • (PMID = 19255738.001).
  • [ISSN] 1433-0563
  • [Journal-full-title] Der Urologe. Ausg. A
  • [ISO-abbreviation] Urologe A
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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93. Kumar N, Kotagal S, Parisi JE, Westmoreland BF: Cerebral hemiatrophy with superficial siderosis and PLEDs due to a germ cell tumor of the basal ganglia. Eur J Neurol; 2006 Aug;13(8):904-7
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  • [Title] Cerebral hemiatrophy with superficial siderosis and PLEDs due to a germ cell tumor of the basal ganglia.
  • The diagnosis of basal ganglia germ cell tumors may be delayed due to slow progression and minimal early changes on magnetic resonance imaging (MRI).
  • The cystic nature of some tumors may lead to non-diagnostic biopsies.
  • We describe the clinical, imaging, laboratory, and postmortem findings of a basal ganglia germ cell tumor in a 19-year-old man.
  • Clues to an early antemortem diagnosis based on MRI findings and determination of tumor markers are discussed.
  • An early diagnosis and accurate characterization of basal ganglia germ cell tumors is essential for optimal therapy.
  • Measurement of serum and cerebrospinal fluid markers such as human chorionic gonadotropin may suggest the diagnosis.
  • [MeSH-major] Basal Ganglia / pathology. Basal Ganglia Diseases / complications. Brain Neoplasms / complications. Cerebral Cortex / pathology. Epilepsy / etiology. Neoplasms, Germ Cell and Embryonal / complications. Siderosis / etiology

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  • (PMID = 16879304.001).
  • [ISSN] 1468-1331
  • [Journal-full-title] European journal of neurology
  • [ISO-abbreviation] Eur. J. Neurol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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94. Muramaki M, Hara I, Miyake H, Yamada Y, Kawabata G, Kamidono S: Clinical study of six cases showing late relapse of germ cell tumors. Int J Urol; 2005 Sep;12(9):855-8
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  • [Title] Clinical study of six cases showing late relapse of germ cell tumors.
  • Late relapse of germ cell tumors has been considered rare.
  • We report six patients treated at our institution with relapses of germ cell tumors more than 2 years after first successful management.
  • Median time to late relapse for pure seminomas and non-seminomatous germ cell tumors was 30.0 and 75.5 months, respectively.
  • Two patients with non-seminomatous germ cell tumors received salvage chemotherapy at the time of late relapse, but tumor markers did not normalize in either case.
  • A complete resection of relapsed masses was performed in three cases of non-seminomatous germ cell tumors.
  • [MeSH-major] Neoplasm Recurrence, Local. Neoplasms, Germ Cell and Embryonal. Testicular Neoplasms

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  • (PMID = 16201988.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
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95. Casellato S, Gazzano G, Musi G, Spinelli M, Carmignani L, Rocco F: First case of bilateral intratubular germ cell tumor in androgen insensivity syndrome. Arch Ital Urol Androl; 2007 Sep;79(3):135-7
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  • [Title] First case of bilateral intratubular germ cell tumor in androgen insensivity syndrome.
  • INTRODUCTION AND OBJECTIVE: Androgen insensivity syndrome is an X-linked recessive disorder caused by a mutation of the androgen receptor gene localized in Xq 11-q12-b.
  • Aim of the study is the description of the first case of bilateral intratubular germ cell tumor in androgen insensivity syndrome.
  • METHODS: In September 2002, a 24-year-old woman with XY karyotype and childhood diagnosis of complete testicular feminization first came under our observation.
  • Only for the right gonad, furthermore, the presence of a round anechoic image could be seen, of about 1.5 cm and small multiple microcalcifications (6).
  • RESULTS: Histological examination revealed the presence of a bilateral intratubular germ cell tumor.
  • In patients with TIN, orchiectomy is a valid therapeutic option, followed by a strict follow-up abdomen/pelvic CT scan, chest XR, tumor markers every three months for the first two years.

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  • (PMID = 18041366.001).
  • [ISSN] 1124-3562
  • [Journal-full-title] Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • [ISO-abbreviation] Arch Ital Urol Androl
  • [Language] ENG
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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96. Boeck S, Metzeler KH, Hausmann A, Baumann A, Gallmeier E, Parhofer KG, Stemmler HJ: Cisplatin-based chemotherapy for pulmonary metastasized germ cell tumors of the testis--be aware of acute respiratory distress syndrome. Onkologie; 2009 Mar;32(3):125-8
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  • [Title] Cisplatin-based chemotherapy for pulmonary metastasized germ cell tumors of the testis--be aware of acute respiratory distress syndrome.
  • BACKGROUND: Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors.
  • In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of a 'tumorassociated' acute respiratory distress syndrome (ARDS) has been hypothesized.
  • CASE REPORT: We report the clinical course of a 19-year-old patient who rapidly developed fatal ARDS during the first cycle of chemotherapy using the PEI regimen (cisplatin, etoposide and ifosfamide) for a metastasized (lung, liver, lymph nodes) germ cell tumor of the testis.
  • [MeSH-major] Cisplatin / administration & dosage. Cisplatin / adverse effects. Giant Cell Tumors / drug therapy. Giant Cell Tumors / secondary. Lung Neoplasms / secondary. Respiratory Distress Syndrome, Adult / chemically induced. Testicular Neoplasms / drug therapy. Testicular Neoplasms / secondary

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • (PMID = 19295253.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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97. Arrigo T, Messina MF, Valenzise M, Rosano M, Alaggio R, Cecchetto G, Zirilli G, De Luca F: Testicular microlithiasis heralding mixed germ cell tumor of the testis in a boy. J Endocrinol Invest; 2006 Jan;29(1):82-5
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  • [Title] Testicular microlithiasis heralding mixed germ cell tumor of the testis in a boy.
  • The clinical implications of the association between testicular microlithiasis (TM) and germ cell tumor (GCT) of the testis are still debated since the natural history of incidentally discovered TM has not been defined.
  • We are reporting the case of a 9-yr-old boy with a mixed GCT who had presented 3 yr earlier with TM and hydrocele.
  • [MeSH-major] Lithiasis / diagnosis. Neoplasms, Germ Cell and Embryonal / diagnosis. Testicular Diseases / diagnosis
  • [MeSH-minor] Child. Humans. Male. Testicular Neoplasms / diagnosis. Testicular Neoplasms / pathology. Testicular Neoplasms / ultrasonography

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  • (PMID = 16553039.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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98. Palenzuela G, Martin E, Meunier A, Beuzeboc P, Laurence V, Orbach D, Frappaz D: Comprehensive staging allows for excellent outcome in patients with localized malignant germ cell tumor of the ovary. Ann Surg; 2008 Nov;248(5):836-41
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comprehensive staging allows for excellent outcome in patients with localized malignant germ cell tumor of the ovary.
  • BACKGROUND: The management of malignant germ cell tumors of the ovary (OMGCT) requires multidisciplinary expertise.
  • We analyze the surgical and medical outcomes of a cohort of patients treated for OMGCT.
  • PATIENTS AND METHODS: Data concerning diagnosis, surgery, and medical decisions were reviewed for all patients seen for postoperative management of OMGCT at the Centre Léon Bérard in Lyon and the Institut Curie in Paris between 1985 and 2003.
  • Sixty patients aged 0.4 to 27.9 years (mean 12.8 years) at diagnosis were included.
  • RESULTS: Twenty (53%) of 38 the International Federation of Gynecology and Obstetrics (FIGO) stage I tumors were staged Ix.
  • All stage Ix tumors had been operated by a nongynecologic surgeon.
  • Relapses occurred in 8 of 24 stage I tumors that were observed (0/8 stage Ia; 5/13 stage Ix (P = 0.044) and 3/3 stage Ic) versus 0/14 stage I treated by adjuvant chemotherapy (P = 0.0015).
  • The risk of relapse was significantly increased if patients underwent postsurgical observation ((HR) = 4.5 (95% CI, 1.5 to 13.3)), and when the tumor contained yolk sac tumor (HR = 7.3 (95% CI, 2.3 to 22.7)).
  • There was no significant prognostic value for age, stage, level of tumor markers at diagnosis, type of surgery, and type of chemotherapy.
  • It allows a safe observation strategy in stage Ia tumors.
  • Patients with stages Ix and Ic tumors may benefit from adjuvant chemotherapy.
  • [MeSH-major] Neoplasms, Germ Cell and Embryonal / surgery. Ovarian Neoplasms / surgery
  • [MeSH-minor] Chemotherapy, Adjuvant. Child. Dysgerminoma / diagnosis. Dysgerminoma / surgery. Endodermal Sinus Tumor / pathology. Endodermal Sinus Tumor / surgery. Fallopian Tubes / surgery. Female. Humans. Neoplasm Staging. Ovariectomy. Radiotherapy, Adjuvant. Retrospective Studies. Teratoma / diagnosis. Teratoma / pathology. Teratoma / surgery. Treatment Outcome

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  • (PMID = 18948812.001).
  • [ISSN] 1528-1140
  • [Journal-full-title] Annals of surgery
  • [ISO-abbreviation] Ann. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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99. Honecker F, Souchon R, Krege S, Bokemeyer C: [A multi-disciplinary approach to the treatment of germ cell tumors]. Internist (Berl); 2010 Nov;51(11):1382-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A multi-disciplinary approach to the treatment of germ cell tumors].
  • [Transliterated title] Multimodale Therapiekonzepte von Keimzelltumoren.
  • The management of patients with germ cell tumors must be based upon complete staging and should be risk-adapted.
  • Prognosis is particularly poor in patients with either primary mediastinal nonseminoma, and/or metastases to liver, brain or bone, or inadequate tumor marker decline.
  • [MeSH-major] Cooperative Behavior. Interdisciplinary Communication. Neoplasms, Germ Cell and Embryonal / drug therapy. Neoplasms, Germ Cell and Embryonal / radiotherapy
  • [MeSH-minor] Biomarkers, Tumor / blood. Combined Modality Therapy. Humans. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / pathology. Neoplasm Recurrence, Local / radiotherapy. Neoplasm Staging. Neoplasm, Residual / drug therapy. Neoplasm, Residual / pathology. Neoplasm, Residual / radiotherapy. Patient Care Team. Prognosis. Seminoma / drug therapy. Seminoma / pathology. Seminoma / radiotherapy

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  • (PMID = 20938625.001).
  • [ISSN] 1432-1289
  • [Journal-full-title] Der Internist
  • [ISO-abbreviation] Internist (Berl)
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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100. Kuroda N, Amano S, Shiotsu T, Tamura M, Hes O, Michal M, Lee GH: Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome. APMIS; 2007 Nov;115(11):1292-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome.
  • We here present a case of mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome.
  • A 20-year-old Japanese man with a mass in the left inguinal region underwent orchidectomy as a left testicular tumor was suspected.
  • Histology showed a mixed germ-cell tumor with embryonal carcinoma and yolk sac tumor with syncytiotrophoblastic giant cells occurring in a cryptorchid testis.
  • Our case provides further evidence that these three conditions-Down's syndrome, cryptorchidism and testicular germ cell tumor-may be closely associated.
  • To our knowledge this is the first case of mixed germ cell tumor arising in a patient with Down's syndrome and cryptorchidism.
  • [MeSH-major] Cryptorchidism / pathology. Down Syndrome / pathology. Neoplasms, Germ Cell and Embryonal / pathology. Testicular Neoplasms / pathology

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  • (PMID = 18092963.001).
  • [ISSN] 0903-4641
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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