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1. Arikawa S, Uchida M, Shinagawa M, Tohnan T, Hayabuchi N: Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst. Kurume Med J; 2006;53(1-2):37-40
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  • [Title] Significance of the " beak sign"in the differential diagnosis of uterine lipoleiomyoma from ovarian dermoid cyst.
  • Although a series of imaging studies suggested a lipomatous tumor, diagnosis was difficult because the tumor appeared as a pedunculated mass extending from the uterine body.
  • To distinguish the tumor from an ovarian lipomatous tumor, the "beak sign" in a magnetic resonance imaging study was diagnostic in this case.
  • The purpose of this paper is to review lipomatous masses of the female pelvis, to discuss the differential diagnosis of the unusual imaging features, and to discuss imaging techniques to optimize pelvic mass characterization.
  • [MeSH-major] Leiomyoma / diagnosis. Lipoma / diagnosis. Ovarian Cysts / diagnosis. Uterine Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Female. Humans. Magnetic Resonance Imaging. Tomography, X-Ray Computed

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  • (PMID = 17043394.001).
  • [ISSN] 0023-5679
  • [Journal-full-title] The Kurume medical journal
  • [ISO-abbreviation] Kurume Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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2. Zemel MB, Sun X: Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr; 2008 Jun;138(6):1047-52
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  • Accordingly, this study was designed to study the effects of the short-term (3 wk) basal suboptimal Ca (0.4%), high-Ca (1.2% from CaCO(3)), and high-dairy (1.2% Ca from milk) obesigenic diets on oxidative and inflammatory stress in adipocyte fatty acid-binding protein-agouti transgenic mice.
  • Adipose tissue reactive oxygen species (ROS) production and NADPH oxidase mRNA and plasma malondialdehyde (MDA) were reduced by the high-Ca diet (P < 0.001) compared with the basal diet and ROS and MDA were further decreased by the high-dairy diet (P < 0.001).
  • The high-Ca and -dairy diets also resulted in suppression of adipose tissue tumor necrosis factor alpha and interleukin (IL)-6 mRNA (P = 0.001) compared with the basal diet, whereas an inverse pattern was noted for adiponectin and IL-15 mRNA (P = 0.002).
  • These data demonstrate that dietary Ca suppresses adipose tissue oxidative and inflammatory stress.

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  • (PMID = 18492832.001).
  • [ISSN] 1541-6100
  • [Journal-full-title] The Journal of nutrition
  • [ISO-abbreviation] J. Nutr.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adiponectin; 0 / Calcium, Dietary; 0 / Dietary Carbohydrates; 0 / Dietary Fats; 9007-41-4 / C-Reactive Protein
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3. Moritani N, Yamada T, Mizobuchi K, Wakimoto M, Ikeya Y, Matsumura T, Mishima K, Iida S: Atypical lipomatous tumor of the tongue: report of a case. Acta Med Okayama; 2010 Aug;64(4):257-61
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  • [Title] Atypical lipomatous tumor of the tongue: report of a case.
  • The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL).
  • This tumor occurs very rarely in the tongue.
  • Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites.
  • A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue.
  • Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless.
  • We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia.
  • Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia.
  • [MeSH-major] Liposarcoma / diagnosis. Tongue Neoplasms / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Humans. Lipoma / diagnosis. Lipoma / pathology. Male. Prognosis. Treatment Outcome

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  • (PMID = 20802543.001).
  • [ISSN] 0386-300X
  • [Journal-full-title] Acta medica Okayama
  • [ISO-abbreviation] Acta Med. Okayama
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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4. Obora A, Kojima T, Kato T, Matsuda H, Horie H, Hashimoto H, Fukuta N, Takano Y, Okuda J, Ida K, Saio M: [An autopsy case of hepatocellular carcinoma in which sarcoma-like changes and peritoneal dissemination were observed after RFA/TACE treatment]. Gan To Kagaku Ryoho; 2009 Jul;36(7):1183-6
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  • Liver biopsy led to a diagnosis of well-differentiated hepatocellular carcinoma.
  • CT revealed pleural effusion/ascites and nodular tumor in the adipose tissue of the parietal peritoneum and mesentery around the liver.
  • Autopsy revealed a tumor involving the liver surface to the peritoneum, suggesting cancerous peritonitis.
  • [MeSH-major] Carcinoma, Hepatocellular / therapy. Catheter Ablation. Chemoembolization, Therapeutic. Liver Neoplasms / therapy

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  • (PMID = 19620814.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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5. Nishida J, Ehara S, Shiraishi H, Tada H, Satoh T, Okada K, Shimamura T: Clinical findings of hibernoma of the buttock and thigh: rare involvements and extremely high uptake of FDG-PET. Med Sci Monit; 2009 Jul;15(7):CS117-22
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  • BACKGROUND: Hibernoma is a rare adipose tissue tumor of the soft tissue and the term is derived from the histological similarities to the brown fat found in hibernating animals.
  • This was not typical of liposarcoma and suggestive of hibernoma.
  • Biopsy specimens revealed a proliferation of adipose cells with vacuolated granular eosinophilic cytoplasm.
  • CONCLUSIONS: While occurrences in the buttock or thigh are exceedingly rare, hibernoma should be included in the differential diagnosis of an adipose tissue tumor in the thigh, even though the imaging findings mimic liposarcoma.
  • A correct diagnosis should be established to prevent over-surgery.

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  • (PMID = 19564831.001).
  • [ISSN] 1643-3750
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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6. Mentzel T, Palmedo G, Kuhnen C: Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases. Mod Pathol; 2010 May;23(5):729-36
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  • [Title] Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases.
  • Well-differentiated spindle cell liposarcoma represents a rare atypical/low-grade malignant lipogenic neoplasm that has been regarded as a variant of atypical lipomatous tumor.
  • However, well-differentiated spindle cell liposarcoma tends to occur in subcutaneous tissue of the extremities, the trunk, and the head and neck region, contains slightly atypical spindled tumor cells often staining positively for CD34, and lacks an amplification of MDM2 and/or CDK4 in most of the cases analyzed.
  • The neoplasms arose on the shoulder, the chest wall, the thigh, the lower leg, the back of the hand, and in paratesticular location.
  • The size of the neoplasms ranged from 1.5 to 10 cm (mean: 6.0 cm).
  • All neoplasms were completely excised.
  • The neoplasms were confined to the subcutis in three cases, and in three cases, an infiltration of skeletal muscle was seen.
  • Histologically, the variably cellular neoplasms were composed of atypical lipogenic cells showing variations in size and shape, and spindled tumor cells with slightly enlarged, often hyperchromatic nuclei.
  • Multivacuolated lipoblasts were present in three neoplasms.
  • Immunohistochemically, CD34 was at least focally positive in all cases, whereas scattered tumor cells only showed a nuclear expression of MDM2 in two neoplasms.
  • Although well-differentiated spindle cell liposarcoma and atypical lipomatous tumor behave clinically similar, it can be speculated on the basis of clinicopathologic and molecular findings that well-differentiated spindle cell liposarcoma may constitute an independent entity rather than a morphologic variant of atypical lipomatous tumor, and may represent the atypical/low-grade counterpart of spindle cell lipoma.
  • [MeSH-major] Hand / pathology. Leg / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology. Thigh / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged

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  • (PMID = 20228779.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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7. Kaneko G, Nishimoto K, Ogata K, Uchida A: [A case of lipomatous tumor arising from the paratesticular lesion]. Hinyokika Kiyo; 2009 Nov;55(11):725-7
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  • [Title] [A case of lipomatous tumor arising from the paratesticular lesion].
  • We encountered a case of lipomatous tumor in the left scrotum, which was clinically and radiologically quite similar to an inguinal hernia.
  • A 75-year-old male patient visited a nearby hospital complaining of a painless left scrotal swelling.
  • The tumor marker levels were within the normal range.
  • A preoperative diagnosis of inguinal hernia containing the omentum was made.
  • Microscopically, most of the tumor consisted of mature adipocytes, some of which had different cellular sizes.
  • [MeSH-major] Genital Neoplasms, Male / pathology. Lipoma / pathology. Scrotum

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  • (PMID = 19946194.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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8. Weaver J, Downs-Kelly E, Goldblum JR, Turner S, Kulkarni S, Tubbs RR, Rubin BP, Skacel M: Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol; 2008 Aug;21(8):943-9
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  • [Title] Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms.
  • Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma can be difficult to distinguish from benign lipomatous neoplasms and other high-grade sarcomas, respectively.
  • Cytogenetics in these tumors has identified ring and giant chromosomes composed of 12q13-15 amplicons including the MDM2 gene.
  • Identifying MDM2 amplification by fluorescence in situ hybridization may prove an adjunctive tool in the diagnosis of lipomatous neoplasms.
  • Dual color fluorescence in situ hybridization employing a laboratory-developed BAC label probe cocktail specific for MDM2 (12q15) and a probe for the centromeric region of chromosome 12 (Abbott Molecular, DesPlaines, IL) was performed on formalin-fixed and paraffin-embedded tissue including whole sections from atypical lipomatous tumors (n=13), dedifferentiated liposarcomas (n=14), benign lipomatous tumors (n=30), and pleomorphic sarcoma, not otherwise specified (n=10), and a tissue microarray containing a variety of high-grade sarcomas (n=63).
  • MDM2/chromosome 12 fluorescence in situ hybridization is a sensitive and specific tool (both 100%) in evaluating low-grade lipomatous neoplasms.
  • Importantly, none of the benign lipomatous lesions were MDM2 amplified and even cells in areas of well-differentiated liposarcomas with minimal cytologic atypia were amplified, making the probe a valuable tool in the diagnosis of even limited biopsy samples of well-differentiated lipomatous neoplasms.
  • [MeSH-major] In Situ Hybridization, Fluorescence / methods. Lipoma / genetics. Liposarcoma / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Aneuploidy. Chromosomes, Human, Pair 12. Gene Amplification. Humans. Nucleic Acid Amplification Techniques. Tissue Array Analysis

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  • (PMID = 18500263.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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9. Kabasawa Y, Katsube K, Harada H, Nagumo K, Terasaki H, Perbal B, Okada N, Omura K: A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 May;103(5):677-82
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  • [Title] A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor.
  • METHODS: We examined morphological aspects of the tumor and immunohistochemical patterns.
  • RESULTS: Tumor proliferation was infiltrative, which did not show apparent encapsulation.
  • Positive immunoreactivity was found for CD-34, CD-99, Ki-67, and connective tissue growth factor/CCN2 in the fibrous region, S-100 in the adipose region, and Notch1 stain was observed in the eccrine sweat gland cells juxtaposed to the tumor adipose tissue, but no reactivity for Bcl-2, alphaSMA, Notch 2-4, CCN1, and CCN3.
  • Specific expression of CCN2 might be significant for the development of the tumor.
  • [MeSH-major] Fibroma / pathology. Head and Neck Neoplasms / metabolism. Head and Neck Neoplasms / pathology. Lipoma / pathology
  • [MeSH-minor] Adipose Tissue / chemistry. Adipose Tissue / pathology. Antigens, CD / analysis. Antigens, CD34 / analysis. Cell Adhesion Molecules / analysis. Connective Tissue Growth Factor. Humans. Immediate-Early Proteins / biosynthesis. Immunohistochemistry. Infant. Insulin-Like Growth Factor Binding Proteins / biosynthesis. Intercellular Signaling Peptides and Proteins / biosynthesis. Ki-67 Antigen / analysis. Male. Neoplasm Proteins / biosynthesis. Nephroblastoma Overexpressed Protein. Receptor, Notch1 / biosynthesis. S100 Proteins / analysis

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  • (PMID = 17466886.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD; 0 / Antigens, CD34; 0 / CD99 protein, human; 0 / CTGF protein, human; 0 / Cell Adhesion Molecules; 0 / Immediate-Early Proteins; 0 / Insulin-Like Growth Factor Binding Proteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ki-67 Antigen; 0 / NOTCH1 protein, human; 0 / NOV protein, human; 0 / Neoplasm Proteins; 0 / Nephroblastoma Overexpressed Protein; 0 / Receptor, Notch1; 0 / S100 Proteins; 139568-91-5 / Connective Tissue Growth Factor
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10. Novikov VV, Novikov GV, Fesenko EE: Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. Bioelectromagnetics; 2009 Jul;30(5):343-51
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  • [Title] Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma.
  • It was shown that the exposure of mice with EAC to combined MFs causes structural changes in some organs (liver, adrenal glands), which are probably due to the total degradation of the tumor tissue.
  • In mice with transplanted EAC, the tumor tissue after exposure to weak MFs was practically absent, as distinct from control animals in which the invasion of the tumor into the adipose tissue surrounding the kidneys, mesenteric lymph nodes, and spermatic appendages was observed.
  • In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism.
  • [MeSH-major] Carcinoma, Ehrlich Tumor / pathology. Carcinoma, Ehrlich Tumor / therapy. Magnetic Field Therapy / methods. Magnetics

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19267367.001).
  • [ISSN] 1521-186X
  • [Journal-full-title] Bioelectromagnetics
  • [ISO-abbreviation] Bioelectromagnetics
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Kurita H, Kamata T, Koike T, Kobayashi H, Kurashina K: Intraoperative tissue staining of invaded oral carcinoma. Pathol Oncol Res; 2008 Dec;14(4):461-5
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  • [Title] Intraoperative tissue staining of invaded oral carcinoma.
  • The purpose of this study was to assess the ability of intraoperative tissue staining with consecutive application of 0.4% indigo carmine and 0.5% Congo red to demonstrate the extent and border of oral carcinoma invasion.
  • Once the oral tumor was resected, a vertical section of surgical specimen was taken from the central part of the tumor.
  • The extent and border of the invaded carcinoma were assessed on digital microscopic examination with tissue staining.
  • Tissue staining produced a brown-black stain on normal muscle, connective, and salivary tissues but not tumor and epithelial tissues.
  • It clearly demonstrated the extent and border of tumor invasion in 13 of 17 patients (76.5%); however, detection of remnant vital tumor cells in scar tissue after neoadjuvant chemotherapy, and distinction between the tumor and adipose tissue scattered in the muscle tissue was difficult.
  • The results of this study showed that intraoperative tissue staining was a possible method in demonstrating the extent and border of carcinoma deeply invaded in the soft tissue and selecting the site for additional frozen section analysis, although the method needed some refinement.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Mouth Neoplasms / pathology. Mouth Neoplasms / surgery. Neoplasm Staging / methods. Staining and Labeling / methods

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  • (PMID = 18575826.001).
  • [ISSN] 1219-4956
  • [Journal-full-title] Pathology oncology research : POR
  • [ISO-abbreviation] Pathol. Oncol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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12. de Groot M, Appelman M, Spuls PI, de Rie MA, Bos JD: Initial experience with routine administration of etanercept in psoriasis. Br J Dermatol; 2006 Oct;155(4):808-14
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  • OBJECTIVES: We hypothesized: (i) that efficacy would be lower than that obtained in published phase II and III studies because (a) resistance to all conventional therapies as a reimbursement condition would select for more resistant cases and (b) inclusion would be more restricted to severe cases (higher PASI), and (ii) that efficacy would be lower in obese patients due to the possible role of adipose tissue in tumour necrosis factor (TNF)-alpha homeostasis.
  • Additionally, we related the clinical effect to the body mass index (BMI), for adipose tissue is thought to have a possible role in TNF-alpha homeostasis.
  • Although fatigue is not identified as a side-effect of etanercept, 10% of our patients reported fatigue as an adverse event during etanercept treatment.
  • Finally, the BMI does not seem to influence the patients' response to etanercept, although further investigations would be needed to confirm this.
  • [MeSH-major] Dermatologic Agents / therapeutic use. Immunoglobulin G / therapeutic use. Psoriasis / drug therapy. Receptors, Tumor Necrosis Factor / therapeutic use

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  • (PMID = 16965432.001).
  • [ISSN] 0007-0963
  • [Journal-full-title] The British journal of dermatology
  • [ISO-abbreviation] Br. J. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Dermatologic Agents; 0 / Immunoglobulin G; 0 / Receptors, Tumor Necrosis Factor; OP401G7OJC / Etanercept
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13. Marsilia GM, Boscaino A, La Mura A, Ceriello A, De Ritis R: Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? Int J Surg Pathol; 2010 Dec;18(6):537-9
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  • Histologically, hepatic angiomyolipoma showed oncocytic features and scanty adipose tissue, the tumor cells expressed desmin, smooth muscle actin, S-100 protein and HMB45.
  • The tumor cells of intramural small intestinal mass were positive for S-100 protein and GFAP and negative for CD117, CD34 and desmin.
  • [MeSH-major] Angiomyolipoma / pathology. Jejunal Neoplasms / pathology. Liver Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Neurilemmoma / pathology

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  • (PMID = 19282295.001).
  • [ISSN] 1940-2465
  • [Journal-full-title] International journal of surgical pathology
  • [ISO-abbreviation] Int. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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14. Scariot R, Giovanini AF, Torres-Pereira CC, Piazzetta CM, Costa DJ, Rebellato NL, Müller PR: Massive growth of an intraoral lipoma. J Contemp Dent Pract; 2008;9(7):115-21
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  • BACKGROUND: Lipoma, a benign tumor of adipose tissue, is rarely seen in the oral cavity.
  • A clinical diagnosis of lipoma was established, and the treatment consisted of complete excision of the mass under local anesthesia.
  • [MeSH-major] Cheek / pathology. Lipoma / pathology. Mouth Neoplasms / pathology

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  • (PMID = 18997924.001).
  • [ISSN] 1526-3711
  • [Journal-full-title] The journal of contemporary dental practice
  • [ISO-abbreviation] J Contemp Dent Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Maruyama K, Motoyama S, Okuyama M, Sasaki K, Sato Y, Hayashi K, Nanjo H, Ogawa J: Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus. Surg Today; 2007;37(2):173-5
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  • [Title] Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus.
  • We describe how we removed a giant pedunculated atypical lipomatous tumor, arising in the cervical to upper thoracic esophagus and occupying a region extending from the cervical to the middle thoracic esophagus, through a cervical esophagotomy without thoracotomy or laparotomy.
  • We suggest that if the base of the tumor is located in the cervical portion of the esophagus, and if the tumor is not aggressive, the cervical approach is best, irrespective of the size of the tumor.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagectomy / methods. Liposarcoma / surgery. Neck / surgery. Thoracotomy / methods

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  • (PMID = 17243042.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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16. Carroll PA, Healy L, Lysaght J, Griffin M, Dunne B, Boyle MT, Reynolds JV, Kennedy MJ, Pidgeon G, Connolly EM: Mammary adipose tissue and cancer cell growth: The role of adipose tissue in the tumor microenvironment. J Clin Oncol; 2009 May 20;27(15_suppl):e22009
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  • [Title] Mammary adipose tissue and cancer cell growth: The role of adipose tissue in the tumor microenvironment.
  • Adipose tissue is considered an important endocrine organ producing several important hormones and cytokines including leptin and adiponectin.
  • Mechanisms for the role of obesity in cancer states includes the excess or unregulated secretion of adipocytokines from adipose tissue, and potentially the metabolic syndrome (a cluster of co-morbidities linked to metabolic dysregulation).
  • Mammary adipose tissue is proposed to play a vital role in the microenvironment of normal and tumour states within the breast<sup>2</sup>.
  • Breast adipose tissue is a good candidate to investigate effects of obesity and metabolic disturbances on cancer states.
  • METHODS: Peritumoural (PT) adipose tissue adjacent to the tumour and distal adipose tissue (D) within the breast was sampled in 10 patients.
  • The tissue was processed and cultured for 72hrs in serum free minimal cytokine media.
  • The adipocytokine profile at the mRNA and protein level was measured in ACM and adipose tissue for comparative differences using RT-PCR, ELISA and Cytokine Profiler technology.
  • RESULTS: ACM from both sites promoted tumour cell survival.
  • This may be mediated through increased pro-inflammatory or pro- mitogenic adipocytokine production in adipose tissue surrounding tumour.

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  • (PMID = 27963182.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Vecchio G, Amico P, Caltabiano R, Colella G, Lanzafame S, Magro G: Spindle cell/pleomorphic lipoma of the oral cavity. J Craniofac Surg; 2009 Nov;20(6):1992-4
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  • We herein report a rare case of a lipomatous tumor of the buccal mucosa, showing intermediate morphological features between spindle cell and pleomorphic lipomas, for which the term spindle cell/pleomorphic lipoma is proposed.
  • Morphological features helpful in the distinction between these tumors are emphasized.
  • [MeSH-major] Lipoma / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Liposarcoma / pathology. Male. Middle Aged. Mouth Mucosa / pathology. Receptors, Androgen / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis

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  • (PMID = 19881383.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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18. McQueen C, Montgomery E, Dufour B, Olney MS, Illei PB: Giant hypopharyngeal atypical lipomatous tumor. Adv Anat Pathol; 2010 Jan;17(1):38-41
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  • [Title] Giant hypopharyngeal atypical lipomatous tumor.
  • Microscopically, they display an admixture of fibrovascular and adipose tissue that is coated by unremarkable squamous mucosa.
  • Here, we report a case that had scattered hyperchromatic cells and lipoblasts within the adipose tissue component.
  • In other anatomic sites similar appearing lesions have been interpreted as pedunculated liposarcomas/atypical lipomatous tumors that are more prone to local recurrences than classic giant fibrovascular polyps.
  • To confirm our suspicion of liposarcomatous differentiation, we performed immunohistochemistry for MDM2 and p53, 2 markers that are known to be negative in benign lipomatous lesions and positive in well-differentiated liposarcomas/atypical lipomatous tumors.
  • The scattered atypical hyperchromatic cells and the lipoblasts both exhibited strong nuclear staining for both markers and supported the diagnosis of pedunculated giant hypopharyngeal atypical lipomatous tumor.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Liposarcoma / pathology
  • [MeSH-minor] Humans. Immunohistochemistry. Male. Middle Aged. Polyps / diagnosis. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 20032637.001).
  • [ISSN] 1533-4031
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 51
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19. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D: Fine needle aspiration of pleomorphic lipoma of the neck: report of two cases. Diagn Cytopathol; 2010 Mar;38(3):184-7
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  • Pleomorphic lipoma is a rare lipocytic neoplasm that most commonly occurs in the head and neck region in middle-aged to elderly men.
  • Histopathologically and cytogenetically, it has some features overlapping with other benign and malignant tumors, such as benign spindle cell lipoma, atypical lipomatous tumor, liposarcoma, and malignant fibrous histiocytoma.
  • Therefore, an accurate preoperative diagnosis is very important for proper treatment.
  • Due to the rarity of this tumor, few cases diagnosed by cytology have been reported in the English literature.
  • [MeSH-major] Head and Neck Neoplasms / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Biomarkers, Tumor / metabolism. Biopsy, Fine-Needle. Chromosome Aberrations. Chromosomes, Human, 16-18. Chromosomes, Human, Pair 13. Diagnosis, Differential. Fat Necrosis / diagnosis. Humans. Incidental Findings. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Neoplasms / pathology. Treatment Outcome

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  • (PMID = 19774616.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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20. Khan N, Afroz N, Fatima U, Raza MH, Rab AZ: Giant primary mesenteric liposarcoma: a rare case report. Indian J Pathol Microbiol; 2007 Oct;50(4):787-9
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  • Primary mesenteric liposarcoma is a rare malignant tumor of mesenchymal origin.
  • These tumors are often found to be of substantial size upon first clinical presentation.
  • We report a case of primary mesenteric liposarcoma in a 55 year old man who underwent laparotomy for the clinical/radiological impression of a mesenteric cyst.
  • Histopathology showed features of atypical lipomatous tumor / well differentiated liposarcoma (ALT/WDLS) with mixed histological pattern (e.g. lipoma like, sclerosing and myxoid areas) varying from area to area.
  • [MeSH-major] Liposarcoma / diagnosis. Liposarcoma / pathology. Mesentery / pathology

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  • (PMID = 18306555.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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21. Jung SM, Chang PY, Luo CC, Huang CS, Lai JY, Hsueh C: Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan. Pediatr Surg Int; 2005 Oct;21(10):809-12
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  • Lipoblastoma/lipoblastomatosis is an uncommon benign lipomatous tumor affecting mainly infants and children.
  • Histologically, the majority (11/16) of primary tumors were of diffuse type.
  • Four patients experienced a recurrence of tumors in the neck (n = 2) and lower extremities (n = 2) 11-84 months after operation.
  • [MeSH-major] Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16180007.001).
  • [ISSN] 0179-0358
  • [Journal-full-title] Pediatric surgery international
  • [ISO-abbreviation] Pediatr. Surg. Int.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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22. Suster S, Morrison C: Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Histopathology; 2008 Feb;52(3):283-93
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  • [Title] Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue.
  • AIMS: To present eight cases of a distinctive morphological subtype of lipomatous tumour of soft tissue.
  • Four cases arose de novo and four cases presented as local recurrences of previously resected liposarcomas.
  • [MeSH-major] Liposarcoma / pathology. Oncogene Proteins, Fusion / genetics. Proto-Oncogene Proteins c-mdm2 / genetics. RNA-Binding Protein FUS / genetics. Soft Tissue Neoplasms / pathology. Transcription Factor CHOP / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Fatal Outcome. Female. Humans. Immunoenzyme Techniques. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Recurrence, Local. Sclerosis / pathology. Translocation, Genetic

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  • (PMID = 18269578.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Oncogene Proteins, Fusion; 0 / RNA-Binding Protein FUS; 0 / TLS-CHOP fusion protein, human; 147336-12-7 / Transcription Factor CHOP; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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23. Acar GO, Cansiz H, Acioğlu E, Yağiz C, Dervişoğlu S: Atypical lipomatous tumour of the head and neck region with dyspnea and dysphagia: a case report. Eur Arch Otorhinolaryngol; 2007 Aug;264(8):947-50
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  • [Title] Atypical lipomatous tumour of the head and neck region with dyspnea and dysphagia: a case report.
  • Liposarcoma is one of the most common soft tissue sarcomas in adults.
  • Atypical lipomatous tumour (ALT) rarely occurs in the head and neck region.
  • Histopathologic grade of these tumours affect prognosis of this disease.
  • In this article, a case of a huge ALT arising from the head and neck region and invading nearly entire left hemi-facial region is presented.
  • Clinical and histopathologic features and therapeutic approaches related to this tumour are discussed reviewing the literature.
  • [MeSH-major] Deglutition Disorders / etiology. Dyspnea / etiology. Head and Neck Neoplasms / complications. Liposarcoma / complications
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Female. Follow-Up Studies. Humans. Magnetic Resonance Imaging. Middle Aged


24. Cheng H, Dodge J, Mehl E, Liu S, Poulin N, van de Rijn M, Nielsen TO: Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays. Hum Pathol; 2009 Sep;40(9):1244-51
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  • [Title] Validation of immature adipogenic status and identification of prognostic biomarkers in myxoid liposarcoma using tissue microarrays.
  • Expression profiling followed by tissue microarray validation linked to patient outcome is a powerful approach for validating biological mechanisms and identifying prognostic biomarkers.
  • We applied these techniques to independent series of primary myxoid liposarcomas in an effort to assess markers of adipose differentiation in myxoid liposarcoma and to identify prognostic markers that can be efficiently assessed by immunohistochemistry.
  • Candidate genes were selected based on analysis of expression profiles from 9 primary myxoid/round liposarcomas and 45 other soft tissue tumors, and by reference to publicly available data sets.
  • Protein products were validated on an adipose neoplasm tissue microarray, including 32 myxoid liposarcomas linked to patient outcome.
  • [MeSH-major] Adipogenesis. Biomarkers, Tumor / analysis. Liposarcoma, Myxoid / genetics. Soft Tissue Neoplasms / genetics. Tissue Array Analysis / methods

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  • (PMID = 19368956.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Insulin-Like Growth Factor Binding Protein 2; EC 2.7.10.1 / Proto-Oncogene Proteins c-ret; EC 2.7.10.1 / Receptor, IGF Type 1
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25. Doğan R, Kara M, Yazicioğlu A, Onder S: Giant atypical lipomatous tumor of the mediastinum. Tuberk Toraks; 2008;56(1):100-3
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  • [Title] Giant atypical lipomatous tumor of the mediastinum.
  • Atypical lipomatous tumors, so-called well differentiated liposarcomas are the intermediate or locally aggressive form of adipocytic tumors.
  • Mediastinum is an uncommon localization for these tumors and they have a potential risk of recurrence following excision.
  • We herein report a case with a giant atypical lipomatous tumor located at the mediastinum that was surgically excised.
  • [MeSH-major] Liposarcoma / surgery. Mediastinal Neoplasms / surgery

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  • (PMID = 18330763.001).
  • [ISSN] 0494-1373
  • [Journal-full-title] Tüberküloz ve toraks
  • [ISO-abbreviation] Tuberk Toraks
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
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26. Fernandez-Flores A, Juanes F: Value of cytological imprints in the diagnosis of atypical lipomatous tumor. Diagn Cytopathol; 2005 Jan;32(1):51-2
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  • [Title] Value of cytological imprints in the diagnosis of atypical lipomatous tumor.
  • The diagnosis of atypical lipomatous tumor by biopsy, requires careful examination of several slides, in order to look for atypical cells.
  • We suggest that imprints of lipomatous tumors may play a complementary role in such a search, and report a case of a 74-yr-old woman with an atypical lipomatous tumor of the left thigh, in which imprints helped to make the diagnosis..
  • [MeSH-major] Cytodiagnosis / methods. Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • [Copyright] (c) 2005 Wiley-Liss, Inc.
  • (PMID = 15584038.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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27. Vicioso L, Gallego E, Sanz A: Cutaneous mixed tumor with lipomatous stroma. J Cutan Pathol; 2006 Sep;33 Suppl 2:35-8
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  • [Title] Cutaneous mixed tumor with lipomatous stroma.
  • AIM: Mixed tumors are usually composed of two components, one epithelial and the other mesenchymal.
  • The latter component is commonly myxoid or myxochondroid; a massively lipomatous stroma is very unusual.
  • To date, only two cases of mixed tumor of the skin have been reported with this type of stroma.
  • METHODS AND RESULTS: We report the case of a 61-year-old man with a mixed tumor situated on the hand, an unusual site for these tumors, with over 90% of the tumor composed of adipose tissue.
  • The tumor was a well-circumscribed, 4.5-cm mass, with the gross appearance of a lipoma.
  • The lipomatous stroma contained nests and ribbons of epithelial cells, with occasional tubular structures, surrounded by a scarce amount of fibromyxoid tissue.
  • Immunohistochemical study showed findings similar to those seen in classic mixed tumors.
  • CONCLUSION: Together with a few other cases in the skin and parotid gland, this report shows how massive adipose differentiation can arise in a mixed tumor of the skin.
  • [MeSH-major] Adipose Tissue / pathology. Fibroma / pathology. Mixed Tumor, Malignant / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Differentiation. Humans. Immunohistochemistry. Male. Middle Aged

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  • (PMID = 16972952.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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28. Kuhnen C, Mentzel T, Lehnhardt M, Homann HH, Sciot R, Debiec-Rychter M: [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition]. Pathologe; 2010 Mar;31(2):129-34
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  • [Title] [Lipoma and atypical lipomatous tumor within the same neoplasia: Evidence for a continuous transition].
  • [Transliterated title] Lipom und atypischer lipomatöser Tumor innerhalb einer Neoplasie: Hinweis für einen kontinuierlichen Ubergang.
  • The case of a lipomatous tumor with a predominant lipoma component and transition to an atypical lipomatous tumor is presented.
  • A deep-seated soft tissue tumor of the right thigh with a maximum size of 14 cm was resected in a 70-year-old female patient.
  • In the remaining portion (approximately 20%) histopathology showed an atypical lipomatous tumor (ALT, lipoma-like subtype).
  • Interphase dual-color fluorescence in situ hybridization showed no amplification of the MDM 2 gene and rarely CDK4 gene amplification within the lipoma component, but high level amplification of MDM 2/CDK4 gene in the ALT area, further supporting the morphologically based diagnosis of a lipomatous tumor including areas of a true lipoma and ALT.
  • This case underlines the concept of a continuous stepwise development of lipomatous soft tissue tumors from benign to malignant counterparts as a biological continuum.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Aged. Biomarkers, Tumor / genetics. Cyclin-Dependent Kinase 4 / genetics. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. In Situ Hybridization, Fluorescence. Proto-Oncogene Proteins c-mdm2 / genetics. Thigh

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  • (PMID = 20063101.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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29. Walter M, Liang S, Ghosh S, Hornsby PJ, Li R: Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene; 2009 Jul 30;28(30):2745-55
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  • [Title] Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells.
  • Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated.
  • Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model.
  • Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs.
  • Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells.

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  • [CommentIn] Oncogene. 2010 Apr 29;29(17):2599-600; author reply 2601-3 [20140019.001]
  • (PMID = 19483720.001).
  • [ISSN] 1476-5594
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA093506-08; United States / NCI NIH HHS / CA / R01 CA093506; United States / NCI NIH HHS / CA / R01 CA093506-05A1; United States / NCI NIH HHS / CA / CA093506-05A1; United States / NCI NIH HHS / CA / CA93506; United States / NCI NIH HHS / CA / CA093506-08
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cofilin 1; 0 / Interleukin-6; 0 / ROCK1 protein, human; EC 2.7.11.1 / rho-Associated Kinases
  • [Other-IDs] NLM/ NIHMS111638; NLM/ PMC2806057
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30. Olaleye O, Fu B, Moorthy R, Lawson C, Black M, Mitchell D: Left supraclavicular spindle cell lipoma. Int J Otolaryngol; 2010;2010:942152
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  • Background. Spindle cell lipoma (SCL) is a benign lipomatous tumour, typically occurring in the posterior neck, shoulder or upper back of elderly males.
  • This case highlights a rare presentation of SCL and the need for pre-operative diagnosis. Case Report.
  • CT neck showed a left supraclavicular mass of fatty density with fine internal septations.
  • A low-grade liposarcoma could not be excluded. Histopathology.
  • Conclusion. Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management.

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  • (PMID = 20508829.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2876251
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31. Jaovisidha S, Suvikapakornkul Y, Woratanarat P, Subhadrabandhu T, Nartthanarung A, Siriwongpairat P: MR imaging of fat-containing tumours: the distinction between lipoma and liposarcoma. Singapore Med J; 2010 May;51(5):418-23
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  • INTRODUCTION: This study aimed to retrospectively review the magnetic resonance (MR) imaging features of the lipomatous tumour in order to differentiate between lipoma and liposarcoma.
  • The images were assessed for the number, site, size and margin of the lesions, as well as the signal intensity (homogenous, bright signal on T1-weighted [T1W] image, bright signal suppressed on T1W with fat-suppression image, bright signal on T2-weighted with fat-suppression image), the internal architecture (thin/thick septum, cystic change), the effect on the surrounding tissue (oedema, neurovascular involvement) and the enhancement pattern.
  • RESULTS: A partially ill-defined margin, neurovascular involvement, enhancing thick/nodular septum and a partially bright signal intensity on T1W images were statistically significant MR imaging features that favoured a diagnosis of liposarcoma (p-value is less than 0.0001).
  • Male gender, an internal cystic change and surrounding soft tissue oedema increased the risk of liposarcoma approximately 2.8, 3.5 and 3.5 times, respectively, compared with the reference group (lipoma), but this was not a statistically significant finding.
  • CONCLUSION: Statistically significant MR imaging features that favour a diagnosis of liposarcoma included a partially ill-defined margin, neurovascular involvement, enhancing thick/nodular septum, and a partially bright signal intensity on T1W images.
  • [MeSH-major] Lipoma / diagnosis. Liposarcoma / diagnosis. Magnetic Resonance Imaging. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Confidence Intervals. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Muscle Neoplasms / diagnosis. Muscle Neoplasms / pathology. Odds Ratio. Retrospective Studies. Risk Factors

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  • (PMID = 20593147.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Singapore
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32. Miller DV, Tazelaar HD: Cardiovascular pseudoneoplasms. Arch Pathol Lab Med; 2010 Mar;134(3):362-8
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  • CONTEXT: Primary cardiac tumors are rare and the great majority are benign neoplasms.
  • Mass-forming reactive and pseudoneoplastic growths are less common, but recognizing and distinguishing these lesions from the neoplasms they resemble is critical to appropriate patient care.
  • OBJECTIVE: The general clinical, imaging, gross pathologic, and histologic features of 5 important pseudoneoplasms (inflammatory myofibroblastic tumor, hamartoma of mature cardiac myocytes, mesothelial/monocytic cardiac excrescences, calcified amorphous tumor, and lipomatous hypertrophy of the atrial septum) are discussed, with an emphasis on features differentiating them from other benign and malignant tumors.
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Male

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  • [CommentIn] Arch Pathol Lab Med. 2010 Nov;134(11):1584-6 [21043810.001]
  • (PMID = 20196664.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 37
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33. Shi HY, Wei LX, Wang HT, Sun L: Clinicopathological features of atypical lipomatous tumors of the laryngopharynx. J Zhejiang Univ Sci B; 2010 Dec;11(12):918-22
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  • [Title] Clinicopathological features of atypical lipomatous tumors of the laryngopharynx.
  • Atypical lipomatous tumor (ALT) of the laryngopharynx is rare.
  • All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass.
  • Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5).
  • Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT.
  • Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4).
  • Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up.
  • ALT of laryngopharynx is an indolent tumor.
  • Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.
  • [MeSH-major] Hypopharyngeal Neoplasms / pathology. Lipoma / pathology

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  • (PMID = 21121069.001).
  • [ISSN] 1862-1783
  • [Journal-full-title] Journal of Zhejiang University. Science. B
  • [ISO-abbreviation] J Zhejiang Univ Sci B
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] EC 2.7.11.22 / CDK4 protein, human; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Other-IDs] NLM/ PMC2997399
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34. Katenkamp K, Katenkamp D: Soft tissue tumors: new perspectives on classification and diagnosis. Dtsch Arztebl Int; 2009 Sep;106(39):632-6
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  • [Title] Soft tissue tumors: new perspectives on classification and diagnosis.
  • BACKGROUND: In recent years, new tumor entities have been described and previously known tumor types have undergone a reassessment.
  • This article offers an overview of recent developments in the classification and interpretation of soft tissue tumors.
  • METHODS: Selective review of publications from 1990 until 2008 from the literature database of the Consultation and Referral Center for Soft Tissue Tumors in Jena.
  • The current status of the classification and morphological diagnosis of these tumors is described.
  • RESULTS: The description of the biological behavior of soft tissue tumors has become more detailed with the introduction of two intermediate categories ("intermediate, locally aggressive" and "intermediate, rarely metastasizing").
  • Previously established terms such as "malignant fibrous histiocytoma" or "hemangiopericytoma" will be used much less often in future, because these tumor types have been reinterpreted.
  • The WHO recommends that highly differentiated liposarcoma be renamed "atypical lipomatous tumor."
  • The importance of molecular tumor characterization for individually tailored therapy is already becoming clear.
  • CONCLUSIONS: Optimal diagnosis is the prerequisite for effective therapy and can be achieved only with state-of-the-art knowledge of the pathology of soft tissue tumors.
  • [MeSH-major] Soft Tissue Neoplasms / classification. Soft Tissue Neoplasms / diagnosis

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  • (PMID = 19890408.001).
  • [ISSN] 1866-0452
  • [Journal-full-title] Deutsches Ärzteblatt international
  • [ISO-abbreviation] Dtsch Arztebl Int
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 21
  • [Other-IDs] NLM/ PMC2770206
  • [Keywords] NOTNLM ; biopsy / cancer diagnosis / molecular biology / molecular medicine / soft-tissue sarcoma
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35. Mandal RV, Duncan LM, Austen WG Jr, Nielsen GP: Infiltrating intramuscular spindle cell lipoma of the face. J Cutan Pathol; 2009 Oct;36 Suppl 1:70-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell lipoma is a benign lipomatous tumor, which usually arises on the back of the neck, shoulder or upper back of males in the third to seventh decade of life.
  • We report herein an unusual infiltrating intramuscular spindle cell lipoma arising in the nose of a 53-year-old man.
  • Histologically, a proliferation of mature adipocytes, ropey collagen fibers and spindle cells within a myxoid stroma was present in the subcutaneous tissue and infiltrated between skeletal muscle fibers.
  • [MeSH-major] Lipoma / pathology. Neoplasm Recurrence, Local / pathology. Nose Neoplasms / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 19187113.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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36. Nilsson M, Domanski H, Mertens F, Mandahl N: Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12. Oncol Rep; 2005 Apr;13(4):649-52
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Atypical lipomatous tumor with rare structural rearrangements involving chromosomes 8 and 12.
  • Atypical lipomatous tumor (ALT), an intermediate malignant neoplasm of soft tissues, is characterized by the presence of supernumerary ring and giant marker chromosomes.
  • The complex rearrangement was not only the result of multiple breaks and reunions of these chromosomes, but was also associated with a gain of chromosome 12 sequences.
  • Whether ALTs with these types of aberrations have a lower risk of tumor progression than ALTs with the notoriously mitotically unstable ring and giant marker chromosomes remains to be investigated.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 8. Lipoma / genetics. Lipoma / pathology. Neoplasms, Adipose Tissue / genetics. Neoplasms, Adipose Tissue / pathology
  • [MeSH-minor] Biopsy. Chromosome Banding. Chromosomes / ultrastructure. Disease Progression. Female. Humans. In Situ Hybridization, Fluorescence. Interphase. Karyotyping. Middle Aged. Phenotype

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  • (PMID = 15756437.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
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37. Schmack I, Patel RM, Folpe AL, Wojno T, Zaldivar RA, Balzer B, Kang SJ, Weiss SW, Grossniklaus HE: Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor. Am J Surg Pathol; 2007 Feb;31(2):193-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
  • Over the past several years, we have seen a number of cases in which this prolapsed fat was confused pathologically with a neoplasm of adipocytic lineage, specifically pleomorphic lipoma and atypical lipomatous neoplasm (well-differentiated liposarcoma).
  • We conclude that subconjunctival herniated orbital fat commonly contains multinucleated floretlike giant cells, fibrous septae, and Lochkern cells, features that may result in diagnostic confusion with pleomorphic lipoma and atypical lipomatous neoplasms.
  • Importantly, specific diagnostic features, such as aggregates of bland spindled cells associated with wiry collagen, as seen in pleomorphic lipoma, and enlarged hyperchromatic cells within fibrous septae, as in atypical lipomatous neoplasms, are entirely absent in herniated orbital fat.
  • Multinucleated floret cells present in prolapsed orbital fat likely represent a reactive phenomenon, as they are not present in normal orbital fat.
  • [MeSH-major] Adipose Tissue / pathology. Conjunctiva / pathology. Conjunctival Diseases / pathology. Eye Neoplasms / diagnosis. Lipoma / diagnosis. Liposarcoma / diagnosis. Orbit / pathology
  • [MeSH-minor] Adipocytes / metabolism. Adipocytes / pathology. Adult. Aged. Aged, 80 and over. Biomarkers / metabolism. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Prolapse. Tomography, X-Ray Computed

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  • (PMID = 17255763.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Grant] United States / NEI NIH HHS / EY / P30-EY06360
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers
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38. O'Neill JK, Stone CA, Sarsfield P, Smith M, Smithson SF, Silver D, Devaraj VS: An association of multiple well differentiated liposarcomas, lipomatous tissue and hereditary retinoblastoma. Sarcoma; 2005;9(3-4):151-6
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  • [Title] An association of multiple well differentiated liposarcomas, lipomatous tissue and hereditary retinoblastoma.
  • Well differentiated liposarcoma (atypical lipomatous tumour) is a low grade tumour, with no metastatic potential unless dedifferentiation supervenes.
  • We present a patient in whom bilateral childhood retinoblastoma was followed by later development of massive confluent areas of low grade liposarcoma and lipomatous tissue affecting the upper extremities and trunk.

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  • (PMID = 18521424.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2395631
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39. Yalniz E, Alicioglu B, Oz Puyan F: Hibernoma: a benign lipomatous tumor mimicking liposarcoma. J BUON; 2008 Jan-Mar;13(1):127-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Hibernoma: a benign lipomatous tumor mimicking liposarcoma.
  • Hibernoma is a rare, benign, slow-growing soft tissue tumor.
  • Due to its rich vascularity and magnetic resonance appearance, this tumor may mimic a liposarcoma before tissue diagnosis.
  • Malignant potential has not been demonstrated.
  • The clinical presentation, radiographic and histopathologic features of this rare benign soft tissue tumor are presented.
  • This tumor is clinically important because it is indistinguishable from malignant lesions.
  • [MeSH-major] Lipoma / pathology. Liposarcoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 18404800.001).
  • [ISSN] 1107-0625
  • [Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology
  • [ISO-abbreviation] J BUON
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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40. Saifzadeh S, Derakhshanfar A, Hadian M: Congenital lipoblastoma in a neonate calf: first report in veterinary literature. Vet Dermatol; 2007 Apr;18(2):130-3
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  • Lipoblastoma is a rare benign tumour of adipose tissue that usually occurs in young children.
  • This case report describes the clinical and histopathological findings of a congenital lipoblastoma located at the tail base of a 2-day-old male calf.
  • Lipoblastoma should thus be considered in the differential diagnosis list for congenital adipose tissue tumours in animals.
  • [MeSH-major] Cattle Diseases / diagnosis. Lipoma / veterinary. Skin Neoplasms / veterinary
  • [MeSH-minor] Animals. Animals, Newborn. Cattle. Diagnosis, Differential. Male. Tail

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  • (PMID = 17355429.001).
  • [ISSN] 0959-4493
  • [Journal-full-title] Veterinary dermatology
  • [ISO-abbreviation] Vet. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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41. Michaelidis IG, Stefanopoulos PK, Sambaziotis D, Zahos MA, Papadimitriou GA: Sialolipoma of the parotid gland. J Craniomaxillofac Surg; 2006 Jan;34(1):43-6
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  • A case of slow-enlarging mass of the parotid region in a 44-year-old male is presented, which proved to be a lipomatous tumour of the parotid gland.
  • The clinical impression was that of a benign salivary gland tumour.
  • The tumour was situated in the deep lobe of the gland, thus a total parotidectomy was performed, with preservation of the facial nerve.
  • Microscopically the lesion was described as consisting of mature adipose tissue, which, however, encompassed both glandular elements and nerve bundles within it.
  • This tumour has been recently recognized as a separate entity under the term 'sialolipoma'.
  • [MeSH-major] Lipoma / pathology. Parotid Neoplasms / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Adult. Diagnosis, Differential. Facial Nerve / pathology. Follow-Up Studies. Humans. Male. Parotid Gland / innervation

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  • (PMID = 16343917.001).
  • [ISSN] 1010-5182
  • [Journal-full-title] Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
  • [ISO-abbreviation] J Craniomaxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Scotland
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42. Gokhale U, Pillai GR, Varghese PV, Samarsinghe D: Chondroid lipoma: a case report. Oman Med J; 2008 Apr;23(2):116-7
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  • Chondroid lipoma is a unique, uncommon benign lipomatous tumour.
  • We report such a neoplasm with brief a review of literature.

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  • (PMID = 22379550.001).
  • [ISSN] 1999-768X
  • [Journal-full-title] Oman medical journal
  • [ISO-abbreviation] Oman Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Oman
  • [Other-IDs] NLM/ PMC3282416
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43. Kuriu A, Shimono T, Kuwabara M, Ashikaga R, Hosono M, Murakami T: Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult. Jpn J Radiol; 2010 Feb;28(2):166-8
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  • [Title] Fourth ventricular mixed germ cell tumor demonstrating adipose tissue in a young adult.
  • We report a case of fourth ventricular mixed germ cell tumor (GCT) in a 20-year-old man.
  • Neuroradiological investigations revealed a fourth ventricular hemorrhagic tumor with adipose tissue.
  • We suspected mixed GCT because adipose tissue was seen preoperatively, but mixed GCT occurring after childhood in this location has not previously been reported.
  • We describe herein the imaging findings for mixed GCT and discuss the differential diagnoses of fourth ventricular tumors with adipose tissue.
  • [MeSH-major] Adipose Tissue / pathology. Adipose Tissue / radiography. Brain Neoplasms / diagnosis. Fourth Ventricle / pathology. Fourth Ventricle / radiography. Neoplasms, Germ Cell and Embryonal / diagnosis
  • [MeSH-minor] Adult. Biomarkers / blood. Biomarkers, Tumor / blood. Cerebral Ventriculography / methods. Chorionic Gonadotropin / blood. Contrast Media. Diagnosis, Differential. Follow-Up Studies. Headache / etiology. Humans. Hydrocephalus / complications. Image Enhancement / methods. Magnetic Resonance Imaging / methods. Male. Tomography, X-Ray Computed / methods. Vomiting / etiology. Young Adult. alpha-Fetoproteins

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  • (PMID = 20182853.001).
  • [ISSN] 1867-108X
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Chorionic Gonadotropin; 0 / Contrast Media; 0 / alpha-Fetoproteins
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44. Sadeghian H, Eslami B, Shirani S, Sadeghian A: Lipomatous tumor of the tricuspid valve: report of a rare case. J Heart Valve Dis; 2009 Nov;18(6):720-2
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  • [Title] Lipomatous tumor of the tricuspid valve: report of a rare case.
  • The case is reported of a 19-year-old man with cardiac valve lipomatosis which was accidentally discovered during the work-up for an atypical chest pain.
  • Magnetic resonance imaging showed evidence of tricuspid valve lipomatosis, a rare cardiac valve tumor.
  • After five months, echocardiography showed that the mass had not grown.
  • To the best of the present authors' knowledge, very few reports exist of cardiac valve lipomatous tumors.
  • [MeSH-major] Heart Neoplasms / ultrasonography. Lipoma / ultrasonography. Tricuspid Valve / ultrasonography

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  • (PMID = 20099724.001).
  • [ISSN] 0966-8519
  • [Journal-full-title] The Journal of heart valve disease
  • [ISO-abbreviation] J. Heart Valve Dis.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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45. Yamaguchi T, Takimoto T, Yamashita T, Kitahara S, Omura M, Ueda Y: Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney. Urology; 2005 Jan;65(1):175
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  • [Title] Fat-containing variant of solitary fibrous tumor (lipomatous hemangiopericytoma) arising on surface of kidney.
  • Fat-containing variant of a solitary fibrous tumor is a recently recognized benign soft-tissue tumor that usually affects the thigh and retroperitoneum.
  • We report a 51-year-old woman with a fat-containing variant of a solitary fibrous tumor that is the first reported case involving a visceral organ.
  • The tumor was well delineated and seemed to arise from the renal capsule, radiographically and macroscopically.
  • The tumor microscopically mimicked a solitary fibrous tumor but exhibited focal aggregates of fat cells.
  • A fat-containing variant of a solitary fibrous tumor involving the kidney should be distinguished from spindle cell carcinoma, angiomyolipoma, gastrointestinal stromal tumor, and cellular schwannoma.
  • [MeSH-major] Adipose Tissue / pathology. Hemangiopericytoma / pathology. Kidney Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Diagnosis, Differential. Female. Humans. Middle Aged. Nephrectomy. Tomography, X-Ray Computed

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  • (PMID = 15667897.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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46. Spinelli C, Costanzo S, Severi E, Giannotti G, Massart F: A thoracic wall lipoblastoma in a 3-month-old infant: A case report and review of the literature. J Pediatr Hematol Oncol; 2006 Sep;28(9):594-600
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Lipoblastoma is a rare benign tumor of adipose tissue seen almost always in infancy and early childhood.
  • Lipoblastoma is a tumor with good prognosis with no reported metastases, despite its potential for local invasion and rapid growth.
  • With the aim of both diagnosis and treatment, the lipomatous mass was removed by local resection.
  • In addition to the patient's age, histologic and cytogenetic analyses assisted the diagnosis of diffuse lipoblastoma.
  • [MeSH-major] Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology. Thoracic Wall / pathology

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  • (PMID = 17006266.001).
  • [ISSN] 1077-4114
  • [Journal-full-title] Journal of pediatric hematology/oncology
  • [ISO-abbreviation] J. Pediatr. Hematol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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47. Parratt MT, Gokaraju K, Spiegelberg BG, Miles J, Cannon SR, Briggs TW: Myolipoma affecting the erector spinae: a case report in a child. Case Rep Med; 2009;2009:520126
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  • Myolipoma is a rare, benign, lipomatous tumour which most commonly occurs in the retroperitoneum, pelvis, and abdomen.
  • Magnetic Resonance Imaging (MRI) revealed a soft tissue lesion with high fat content and areas of calcification.
  • Excision and histopathological analysis revealed a tumour composed of lobules of mature adipose tissue and broad septa of well-differentiated smooth muscle tissue.
  • This paper represents the youngest patient diagnosed with this rare soft tissue tumour which is normally confined to the adult population.
  • A newly reported site of the tumour is also highlighted.

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  • [Cites] Am J Surg Pathol. 1991 Feb;15(2):121-5 [1703396.001]
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  • (PMID = 19902012.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2774534
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48. Italiano A, Chambonniere ML, Attias R, Chibon F, Coindre JM, Pedeutour F: Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas. Cancer Genet Cytogenet; 2008 Jul 15;184(2):99-104
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Spindle cell liposarcoma (SCL) is a rare malignant adipose tissue tumor presently regarded as a variant of well-differentiated liposarcoma (WDLPS).
  • In these two cases, we did not identify supernumerary ring or giant chromosomes containing 12q amplification or any other chromosome 12 rearrangement.
  • Monosomy 7 is not usual in adipose tissue tumors.
  • It has been described in myelodysplastic syndromes and acute myeloid or lymphoblastic leukemias, as well as in several benign or malignant solid tumors.
  • Our data suggest that the loss of material from chromosome 7 might play a crucial role in the pathogenesis of some SCL probably through the inactivation of tumor suppressor genes located on chromosome 7.
  • [MeSH-major] Carcinoma / genetics. Chromosomes, Human, Pair 12. Chromosomes, Human, Pair 7. Gene Amplification. Liposarcoma / genetics. Monosomy / diagnosis

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  • (PMID = 18617058.001).
  • [ISSN] 1873-4456
  • [Journal-full-title] Cancer genetics and cytogenetics
  • [ISO-abbreviation] Cancer Genet. Cytogenet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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49. Speer AL, Schofield DE, Wang KS, Shin CE, Stein JE, Shaul DB, Mahour GH, Ford HR: Contemporary management of lipoblastoma. J Pediatr Surg; 2008 Jul;43(7):1295-300
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • PURPOSE: Lipoblastoma is a rare, benign, adipose tissue tumor.
  • We report the largest single institution experience managing these uncommon neoplasms.
  • CONCLUSIONS: A staged approach with meticulous sparing of the neurovascular bundle provides excellent functional outcome for patients with large tumors.
  • [MeSH-major] Neoplasms, Adipose Tissue / surgery. Soft Tissue Neoplasms / surgery

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  • (PMID = 18639685.001).
  • [ISSN] 1531-5037
  • [Journal-full-title] Journal of pediatric surgery
  • [ISO-abbreviation] J. Pediatr. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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50. Miyakura T, Irisawa R, Miyamoto M, Iwaya K, Yamamoto T, Tsuboi R: An atypical case of atypical lipomatous tumor. Am J Dermatopathol; 2008 Dec;30(6):590-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An atypical case of atypical lipomatous tumor.
  • Immunohistochemically, some of the tumor cells were positive for p53 and MDM2.
  • Histologically, the atypical lipomatous tumor, lipoblastoma, spindle cell lipoma, pleomorphic liposarcoma, and hibernoma comprised the list of possible, differential diagnoses.
  • We considered our case to be a variant of atypical lipomatous tumor, although it did not correspond to any of the 4 atypical lipomatous tumor subgroups.
  • [MeSH-major] Adipocytes / pathology. Liposarcoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Female. Humans. Magnetic Resonance Imaging. Middle Aged. Proto-Oncogene Proteins c-mdm2 / metabolism. Tumor Suppressor Protein p53 / metabolism

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  • (PMID = 19033936.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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51. Zhang H, Erickson-Johnson M, Wang X, Oliveira JL, Nascimento AG, Sim FH, Wenger DE, Zamolyi RQ, Pannain VL, Oliveira AM: Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors. Am J Surg Pathol; 2010 Sep;34(9):1304-11
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Molecular testing for lipomatous tumors: critical analysis and test recommendations based on the analysis of 405 extremity-based tumors.
  • Ancillary molecular testing has been advocated for diagnostic accuracy in the differentiation of lipomas from atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDL); however, the implications and specific indications for use are not well-established in the current literature.
  • Herein, we extend previous findings by quantitatively evaluating the impact of molecular testing of lipomatous neoplasms in our routine clinical practice, how it modifies the historical perspective of their clinical course, and the effect of distinct surgical procedures in modulating the risk of local recurrence for these tumors after molecular classification.
  • On the basis of these analyses, we suggest a specific set of basic recommendations for complementary molecular assessment in the diagnosis of lipomatous tumors.
  • Four hundred and five lipomatous neoplasms located in the trunk and extremities were analyzed histologically and for the presence of 12q13-15 amplification on paraffin-embedded tissues by assessing MDM2/CPM amplification.
  • The 405 tumors were histologically classified as ordinary lipoma (n=324), intramuscular lipoma (n=29), and ALT/WDL (n=52).
  • The level of agreement between the histologic diagnosis and the molecular diagnosis was high (96%) but pathologists showed a tendency to overestimate cytologic atypia and the diagnosis of ALT/WDL (precision, 79%; accuracy, 88%).
  • Molecular assessment led to a major diagnostic reclassification in 18 tumors (4%).
  • Eleven of the tumors histologically classified as ALT/WDL were reclassified as ordinary lipoma (n=5) and intramuscular lipoma (n=6); none of which recurred.
  • Multivariate analyses after molecular assessment showed tumor type and type of resection to be associated with the risk of local recurrence.
  • Complementary molecular testing refines the histologic classification of lipomatous tumors and better estimates the impact of surgical procedures on the risk of local recurrence.
  • Pathologists tend to overestimate the degree of cytologic atypia and the indiscriminate use of molecular testing should be avoided, especially for extremity-based tumors.
  • Molecular testing should be considered for "relapsing lipomas," tumors with questionable cytologic atypia (even if widely excised), or for large lipomatous tumors (>15 cm) without diagnostic cytologic atypia.
  • [MeSH-major] Lipoma / genetics. Liposarcoma / genetics. Molecular Diagnostic Techniques. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Chromosomes, Human, Pair 12. DNA, Neoplasm / analysis. Disease-Free Survival. Extremities. Female. GPI-Linked Proteins. Gene Amplification. Humans. In Situ Hybridization, Fluorescence. Male. Metalloendopeptidases / genetics. Metalloendopeptidases / metabolism. Middle Aged. Neoplasm Recurrence, Local. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism. Treatment Outcome

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  • (PMID = 20679883.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / GPI-Linked Proteins; EC 3.4.17.12 / carboxypeptidase M; EC 3.4.24.- / Metalloendopeptidases; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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52. Allon I, Vered M, Dayan D: Liposarcoma of the tongue: clinico-pathologic correlations of a possible underdiagnosed entity. Oral Oncol; 2005 Aug;41(7):657-65
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  • [Title] Liposarcoma of the tongue: clinico-pathologic correlations of a possible underdiagnosed entity.
  • Liposarcoma (LS), one of the most common malignant tumors, is considered as a rarity in the oral cavity, the tongue being the most frequent site for its occurrence.
  • LS of the tongue is a tumor of adult and old age, with a mean age of approximately 62 years and a peak incidence in the seventh and eighth decades.
  • Clinically, it is a long-standing tumor that commonly presents as a solitary nodular mass, but can also present as a multi-nodular lesion.
  • The most common histopathologic type is that of atypical lipomatous tumor (ALT)/well-differentiated LS (75%).
  • LS can be easily misdiagnosed with both benign and malignant lipomatous and non-lipomatous tumors.
  • When a lipomatous lesion is encountered in the oral cavity, and especially in the tongue, LS should certainly be among the lesions that top the list of differential diagnosis.
  • The follow-up must be on a long-term basis since this tumor can recur years after initial surgical treatment and can also undergo dedifferentiation.
  • [MeSH-major] Liposarcoma / pathology. Tongue Neoplasms / pathology

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  • (PMID = 16023982.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Number-of-references] 27
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53. Skipworth RJ, Smith GH, Stewart KJ, Anderson DN: The tip of the iceberg: a giant pelvic atypical lipoma presenting as a sciatic hernia. World J Surg Oncol; 2006;4:33
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  • It illustrates the need to be aware that hernias may not always simply contain intra-abdominal viscera.
  • CASE PRESENTATION: A 36 year old woman presented with an expanding, yet reducible, right gluteal mass, indicative of a sciatic hernia.
  • However, magnetic resonance imaging demonstrated a large intra- and extra-pelvic fatty mass traversing the greater sciatic foramen.
  • The tumour was surgically removed through an abdomino-perineal approach.
  • Subsequent pathological examination revealed an atypical lipomatous tumour (synonym: lipoma-like well-differentiated liposarcoma).
  • CONCLUSION: The presence of a gluteal mass should always suggest the possibility of a sciatic hernia.
  • Although lipoma-like well-differentiated liposarcomas have only a low potential for recurrence, the variable nature of fatty tumours demands that patients require regular clinical and radiological review.

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  • [Cites] Br J Radiol. 2002 Apr;75(892):381-3 [12000699.001]
  • (PMID = 16790047.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1526433
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54. Milczarek R, Klimek J: [Aromatase--key enzyme of estrogen biosynthesis]. Postepy Biochem; 2005;51(4):430-9
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  • It was pointed that unique human CYP19 gene expression results from presence of many tissue specific promoters and alternative splicing.
  • The molecular mechanism of control aromatase cytochrome P450 gene expression in various species ovaries, testes and human adipose tissue and placenta was discussed in details.
  • Because of a very important role of estrogen in breast cancer a molecular base of aberrant expression CYP19 gene in breast tumor and adipose tissue proximal to breast tumor and potential possibility of pharmacological silencing of this gene expression was discussed in the article.
  • [MeSH-minor] Adipose Tissue / metabolism. Animals. Antineoplastic Agents / pharmacology. Bone Development / physiology. Breast Neoplasms / drug therapy. Breast Neoplasms / genetics. Breast Neoplasms / metabolism. Female. Fertility / physiology. Gene Expression / drug effects. Humans. Male. Placenta / metabolism. Reproduction / physiology

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  • (PMID = 16676578.001).
  • [ISSN] 0032-5422
  • [Journal-full-title] Postepy biochemii
  • [ISO-abbreviation] Postepy Biochem.
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Estrogens; EC 1.14.14.1 / Aromatase
  • [Number-of-references] 66
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55. de Vreeze RS, Koops W, Haas RL, van Coevorden F: An unusual case of hemosiderotic fibrohistiocytic lipomatous lesion: correlation of MRI and pathologic findings. Sarcoma; 2008;2008:893918
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  • [Title] An unusual case of hemosiderotic fibrohistiocytic lipomatous lesion: correlation of MRI and pathologic findings.
  • The spectrum of lipomatous lesions ranges from benign to highly malignant disease.
  • Differentiation between these lesions is important to indicate prognosis and choose the most appropriate treatment.
  • Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) is a rare subtype of lipomatous tumor.
  • The diagnosis is usually based on clinical, histological, and immunohistochemical information.
  • Where magnetic resonance (MR) imaging is a suitable modality to assess fatty tumors, no data is reported on MR imaging of HFLL.

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  • (PMID = 18584051.001).
  • [ISSN] 1357-714X
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2435605
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56. Brandal P, Bjerkehagen B, Heim S: Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology. J Pathol; 2006 Feb;208(3):388-94
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  • [Title] Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology.
  • Cytogenetics is of considerable value when diagnosing lipomatous tumours, as different tumour types have different more or less specific chromosomal abnormalities.
  • One such entity is lipoblastoma, which is a benign lipomatous tumour that often exhibits rearrangements of chromosome bands 8q11-13, and the gene PLAG1 has been implicated as the target of these chromosomal changes.
  • All lipomatous tumours karyotyped at the Norwegian Radium Hospital were reviewed, looking for rearrangements of 8q11-13.
  • The findings raise the question as to what extent the diagnosis lipoblastoma should be based on histopathological or cytogenetic/molecular data or a combination thereof.
  • When karyotypic information from this series was combined with available literature data, it was found that the sensitivity of 8q11-13 rearrangements for diagnosing lipoblastomas when found in a lipomatous tumour was 77% and that the corresponding specificity was 98%.
  • The validity of these calculations of the diagnostic information provided by the cytogenetic findings is, of course, totally dependent on the morphological diagnosis made in each case.
  • Regardless of what the precise phenotypic diagnosis was, it is suggested that lipomatous tumours with 8q11-13 rearrangement constitute a distinct pathogenetic entity.
  • When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance.
  • [MeSH-major] Chromosome Aberrations. Chromosomes, Human, Pair 8. Gene Rearrangement. Lipoma / genetics. Neoplasms, Adipose Tissue / genetics

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  • (PMID = 16308870.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA-Binding Proteins; 0 / Genetic Markers; 0 / PLAG1 protein, human
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57. Akhaddar A, Albouzidi A, Elmostarchid B, Gazzaz M, Boucetta M: Sudden onset of paraplegia caused by hemorrhagic spinal epidural angiolipoma. A case report. Eur Spine J; 2008 Sep;17 Suppl 2:S296-8
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  • Spinal epidural angiolipoma is a rare benign tumor containing vascular and mature adipose elements.
  • A bilateral T2-T4 laminectomy was performed to achieve resection of a lipomatous tumor containing area of spontaneous hemorrhage.
  • Histologic examination revealed the tumor as an angiolipoma.
  • Because the prognosis after rapid surgical management of this lesion is favorable, the diagnosis of spinal angiolipoma with bleeding should be considered in the differential diagnosis of hyperacute spinal cord compression.
  • [MeSH-major] Angiolipoma / complications. Hematoma, Epidural, Spinal / etiology. Hemorrhage / complications. Paraplegia / etiology. Spinal Cord Compression / etiology. Spinal Neoplasms / complications
  • [MeSH-minor] Back Pain / etiology. Decompression, Surgical. Diagnosis, Differential. Disease Progression. Epidural Space / pathology. Epidural Space / physiopathology. Humans. Laminectomy. Magnetic Resonance Imaging. Male. Middle Aged. Spinal Cord / pathology. Spinal Cord / physiopathology. Spine / pathology. Spine / physiopathology. Thoracic Vertebrae / pathology. Thoracic Vertebrae / physiopathology. Treatment Outcome

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  • [Cites] Neurochirurgie. 2000 Dec;46(6):523-533 [11148405.001]
  • [Cites] Acta Neurochir (Wien). 2004 Mar;146(3):299-302; discussion 302 [15015054.001]
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  • (PMID = 18228054.001).
  • [ISSN] 1432-0932
  • [Journal-full-title] European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
  • [ISO-abbreviation] Eur Spine J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Other-IDs] NLM/ PMC2525899
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58. Kocaoğlu B, Erol B, Yalçin S, Bozkurt S, Altun E: Pediatric diffuse lipoblastomatosis of the foot -- a case report and review of the literature. Eur J Pediatr Surg; 2006 Jun;16(3):217-21
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Diffuse lipoblastomatosis is a rare lipomatous tumor of infancy that derives from fetal-embryonal fat.
  • In spite of its benign nature, the tumor may behave in a locally aggressive manner and invade the surrounding tissues.
  • A case of isolated diffuse lipoblastomatosis of a 5-year-old boy in the plantar aspect of his right foot that has not been documented in that area before is described.
  • The clinical and radiological presentation and histologic evaluation of diffuse lipoblastomatosis are discussed, in order to make a differential diagnosis between this rare tumor and other soft tissue tumors.
  • In addition, the treatment principles of the tumor are described.
  • [MeSH-major] Foot Diseases / diagnosis. Lipoma / diagnosis

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  • (PMID = 16909365.001).
  • [ISSN] 0939-7248
  • [Journal-full-title] European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie
  • [ISO-abbreviation] Eur J Pediatr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 11
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59. Evans HL: Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol; 2007 Jan;31(1):1-14
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  • [Title] Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years.
  • Sixty-one cases of neoplasms composed wholly or in part of atypical lipomatous tumor were reviewed.
  • The cases were divided into 4 groups based on the findings in the initial excision specimen: conventional atypical lipomatous tumor (n=15), cellular atypical lipomatous tumor (n=21), dedifferentiated liposarcoma (n=24), and atypical lipomatous tumor with a pleomorphic liposarcoma-like component (n=1).
  • The term "cellular atypical lipomatous tumor" was applied to atypical lipomatous tumors having areas of increased cellularity that when non-lipogenic lacked the 5 mitotic figures per 10 high-power fields (maximal rate) required for a dedifferentiated component and when lipogenic fell short of being truly pleomorphic liposarcoma-like.
  • The most important prognostic factor was tumor location, as none of the 12 patients with a subcutaneous or intramuscular neoplasm died of tumor.
  • Among the 49 patients with neoplasms of central body sites (mostly retroperitoneum), those with dedifferentiated liposarcoma had significantly shorter survival (median 77 mo) than those with cellular (median 142 mo) or conventional (median 209 mo) atypical lipomatous tumor, whereas there was no statistically significant difference between the latter 2 categories.
  • Patients with atypical lipomatous tumor (either cellular or conventional) in central body sites had significantly shorter survival if the tumor transformed into dedifferentiated liposarcoma in recurrence, and, conversely, those with central body site dedifferentiated liposarcoma had significantly longer survival if it recurred as atypical lipomatous tumor.
  • [MeSH-major] Liposarcoma / secondary. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Age Distribution. Aged. Follow-Up Studies. Humans. Middle Aged. Mitosis. Neoplasm Recurrence, Local. Prognosis. Survival Rate

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  • (PMID = 17197914.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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60. Patel J, Deb R, Speake W, Macculloch TA: Primary small bowel liposarcoma (atypical lipomatous tumour) with myogenic differentiation. Sarcoma; 2010;2010
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  • [Title] Primary small bowel liposarcoma (atypical lipomatous tumour) with myogenic differentiation.
  • Primary small intestinal liposarcomas originating in the small bowel are uncommon with a generally poor prognosis due to the advanced stage at the time of diagnosis.
  • The current case is unusual as the tumour seemingly originated from the bowel and the well-differentiated component was seen extensively infiltrating the bowel wall including the small bowel submucosa.

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  • [Cites] Am J Surg Pathol. 1979 Dec;3(6):507-23 [534388.001]
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  • (PMID = 20706648.001).
  • [ISSN] 1369-1643
  • [Journal-full-title] Sarcoma
  • [ISO-abbreviation] Sarcoma
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Egypt
  • [Other-IDs] NLM/ PMC2913843
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61. He M, Aisner S, Benevenia J, Patterson F, Harrison LE, Hameed M: Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma. Pathol Res Pract; 2009;205(6):386-94
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  • The atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive subtype of liposarcoma unless dedifferentiation occurs.
  • The mechanism driving this progression is not clear.
  • Loss of p16 is believed to be an early and critical event in tumor progression.
  • Gene silencing by methylation of p16INK4a gene promoter has been reported in several soft tissue sarcomas.
  • The aim of this study is to study the role of p16INK4a gene promoter methylation and p16 expression in tumor progression (dedifferentiation) and recurrence of ALT/WDLPS.
  • The other two DDLPS and three recurrent WDLPS were not methylated.
  • All three recurrent WDLPS showed positive p16 expression with similar intensity between primary and recurrent tumors.
  • Even though linear correlation between p16 promoter hypermethylation and p16 protein expression was not present, there appears to be a role for p16INK4a gene promoter hypermethylation in DDLPS and not in recurrent WDLPS.
  • [MeSH-major] Cell Dedifferentiation / genetics. Epigenesis, Genetic. Genes, p16. Liposarcoma / genetics. Soft Tissue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged, 80 and over. Cyclin-Dependent Kinase Inhibitor p16 / biosynthesis. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation / genetics. Female. Humans. Immunohistochemistry. Male. Middle Aged. Neoplasm Recurrence, Local / genetics. Neoplasm Recurrence, Local / metabolism. Neoplasm Recurrence, Local / pathology. Promoter Regions, Genetic / genetics. Proto-Oncogene Proteins c-mdm2 / biosynthesis. Retinoblastoma Protein / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis

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  • (PMID = 19186005.001).
  • [ISSN] 1618-0631
  • [Journal-full-title] Pathology, research and practice
  • [ISO-abbreviation] Pathol. Res. Pract.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Retinoblastoma Protein; 0 / Tumor Suppressor Protein p53; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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62. Takahira T, Oda Y, Tamiya S, Yamamoto H, Kobayashi C, Izumi T, Ito K, Iwamoto Y, Tsuneyoshi M: Alterations of the RB1 gene in dedifferentiated liposarcoma. Mod Pathol; 2005 Nov;18(11):1461-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Dedifferentiated liposarcoma is a malignant adipocytic neoplasm containing a non-lipogenic sarcoma of variable histological grade that arises against the background of a pre-existing well-differentiated liposarcoma.
  • The phenomenon of dedifferentiation is considered to be time-dependent, but the mechanism is not well known.
  • The retinoblastoma protein, encoded by the RB1 gene located at 13q14, is a key regulator of proliferation, development, and differentiation of certain cell types, including adipocytes.
  • [MeSH-major] Liposarcoma / genetics. Retinoblastoma Protein / genetics. Soft Tissue Neoplasms / genetics

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  • [Copyright] .Modern Pathology (2005) 18, 1454-1460. doi:10.1038/modpathol.3800444; published online 20 May 2005.
  • (PMID = 15933756.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Retinoblastoma Protein
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63. Willmore-Payne C, Holden J, Turner KC, Proia A, Layfield LJ: Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe. Arch Pathol Lab Med; 2008 Jun;132(6):952-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Amplifications occur within the 12q13-15 region of atypical lipomatous tumors and well-differentiated liposarcomas but not lipomas.
  • OBJECTIVE: To investigate the performance characteristics of the LSI CHOP Breakapart Rearrangement Probe for the diagnosis of myxoid/round cell liposarcomas and atypical lipomas/well-differentiated liposarcomas.
  • DESIGN: We investigated a series of lipomatous neoplasms (5 lipomas, 5 well-differentiated liposarcomas, 22 myxoid/round cell liposarcomas, 2 liposarcomas not otherwise specified, and 2 dedifferentiated liposarcomas) and normal myometrium for abnormalities in the q13-15 region of chromosome 12.
  • Cases were studied for the presence or absence of t(12;16)(q13;p11) or t(12;22)(q13;q12) translocations by the LSI CHOP Breakapart Rearrangement Probe.
  • Rearrangements were seen in 1 dedifferentiated liposarcoma but not in normal myometrium or lipomas.
  • The probe also demonstrated amplification of the 12q13-15 region in well-differentiated liposarcomas, making it useful for the diagnosis of these neoplasms.
  • [MeSH-major] Chromosomes, Human, Pair 12 / genetics. DNA, Complementary. Liposarcoma / diagnosis. Liposarcoma / genetics. Transcription Factor CHOP / genetics

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  • (PMID = 18517278.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DDIT3 protein, human; 0 / DNA, Complementary; 0 / Reagent Kits, Diagnostic; 147336-12-7 / Transcription Factor CHOP
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64. Plaza JA, Wakely PE Jr, Suster S: Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation. Am J Surg Pathol; 2006 Mar;30(3):337-44
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation.
  • Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes.
  • Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue.
  • We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features.
  • The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years.
  • Four tumors predominantly showed features of schwannoma and one of neurofibroma; however, intimately admixed with the spindle cell population, there were also numerous scattered mature adipocytes as well as lipoblast-like cells displaying a signet-ring cell appearance.
  • The signet-ring cells were negative for mucin stains, cytokeratin, EMA, CEA, and several other differentiation markers.
  • The signet-ring cells contained large cytoplasmic lipid droplets that displaced the nuclei to the periphery, consistent with lipoblastic differentiation, whereas complex, interdigitating cytoplasmic processes covered by basal lamina material characteristic of nerve sheath differentiation could be identified in the spindle cells.
  • The presence of mature fat and signet-ring lipoblast-like cells within a nerve sheath neoplasm is quite rare and may signify a process of aberrant differentiation.
  • Neurogenic tumors should be added in the differential diagnosis of spindle cell tumors capable of displaying prominent signet-ring cell features.
  • [MeSH-major] Adipose Tissue / pathology. Nerve Sheath Neoplasms / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adult. Carcinoma, Signet Ring Cell / pathology. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron, Transmission. Middle Aged

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  • (PMID = 16538053.001).
  • [ISSN] 0147-5185
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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65. He M, Aisner S, Benevenia J, Patterson F, Aviv H, Hameed M: p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma. Appl Immunohistochem Mol Morphol; 2009 Jan;17(1):51-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.
  • Atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) is a locally aggressive malignant mesenchymal neoplasm, resembling ordinary lipoma in many clinical aspects.
  • Fifty cases of lipomatous neoplasms, with cytogenetic results, from 45 patients were collected from the archives in Department of Pathology, University of Medicine and Dentistry of New Jersey/New Jersey Medical School during 1998 to 2006.

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  • (PMID = 18779733.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Neoplasm Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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66. Coindre JM, Pédeutour F, Aurias A: Well-differentiated and dedifferentiated liposarcomas. Virchows Arch; 2010 Feb;456(2):167-79
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Atypical lipomatous tumor or well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) share the same basic genetic abnormality characterized by a simple genomic profile with a 12q14-15 amplification involving MDM2 gene.
  • These tumors are the most frequent LPS.

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  • (PMID = 19688222.001).
  • [ISSN] 1432-2307
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 46
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67. Gurel D, Kargi A, Lebe B: Pedunculated cutaneous spindle cell/pleomorphic lipoma. J Cutan Pathol; 2010 Sep;37(9):e57-9
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  • Spindle cell/pleomorphic lipoma is an infrequently seen benign adipose tissue tumor.
  • This tumor, mostly arising from the subcutaneous tissue, usually affects male patients and occurs in back, shoulders, head and neck area.
  • [MeSH-major] Lipoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Antigens, CD34 / metabolism. Biomarkers, Tumor / metabolism. Dermis / pathology. Humans. Male. Vimentin / metabolism

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  • (PMID = 19678825.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; 0 / Vimentin
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68. Fernandes H, Naik CN, Swethadri GK, Bangera I, Miranda D: Pure lipoma of the uterus: a rare case report. Indian J Pathol Microbiol; 2007 Oct;50(4):800-1
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  • Pure fatty tumors of the uterus are exceedingly rare.
  • The more common lipomatous tumor is lipoleiomyoma with varying amounts of two components.
  • Computed Tomography and Magnetic Resonance Imaging can assist in pre-operative diagnosis.
  • Ultrasound revealed fibroid uterus with lipomatous areas.
  • As clinical symptoms and signs of uterine lipoma are indistinguishable from uterine leiomyoma, various imaging techniques can aid in pre-operative diagnosis.
  • The diagnosis of pure lipoma of the uterus should only be made when any smooth muscle if present is confined to the periphery of the tumor.
  • [MeSH-major] Lipoma / diagnosis. Lipoma / pathology. Uterine Neoplasms / diagnosis. Uterine Neoplasms / pathology
  • [MeSH-minor] Abdomen / ultrasonography. Diagnosis, Differential. Female. Humans. Hysterectomy. Leiomyoma / diagnosis. Leiomyoma / pathology. Middle Aged. Uterus / pathology

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  • (PMID = 18306560.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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69. Yoshida T, Saito J, Ichimaru N, Miyagawa Y, Nishimura K, Okuyama A, Tomita H, Aozasa K: [Local recurrence of spermatic cord liposarcoma: a case report]. Hinyokika Kiyo; 2006 Jul;52(7):581-4
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  • A 46-year-old man had undergone radical high orchiectomy because of a tumor of the right spermatic cord.
  • Pathological diagnosis was atypical lipomatous tumor.
  • Local recurrence was suspected, and surgical resection of the tumor with a sufficient surgical margin was performed.
  • Pathological diagnosis was well-differentiated liposarcoma, sclerosing type.
  • [MeSH-major] Genital Neoplasms, Male / surgery. Liposarcoma / surgery. Neoplasm Recurrence, Local / surgery. Orchiectomy. Spermatic Cord

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  • (PMID = 16910596.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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70. Funahashi Y, Kamihira O, Isobe Y, Kimura K, Sasa N, Matsuura O: [Retroperitoneal liposarcoma: a case report]. Hinyokika Kiyo; 2006 Mar;52(3):203-5
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  • A 66-year-old male was referred to our hospital for a retroperitoneal tumor that was detected during gallbladder stone examination.
  • Computed tomography (CT) and magnetic resonance imaging (MRI) revealed an extrarenal lipomatous tumor, 20 x 14 x 8 cm in size, in the right retroperitoneal space.
  • He underwent surgical excision of the tumor with concomitant resection of the right kidney and adrenal gland.
  • The resected tissue weighed 730 g.
  • [MeSH-major] Liposarcoma / surgery. Retroperitoneal Neoplasms / surgery

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  • (PMID = 16617874.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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71. Chen CW, Chang WC, Lee HS, Ko KH, Chang CC, Huang GS: MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients. Clin Imaging; 2010 Nov-Dec;34(6):453-7
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  • [Title] MRI features of lipoblastoma: differentiating from other palpable lipomatous tumor in pediatric patients.
  • The purpose of this study was to describe the magnetic resonance imaging (MRI) features of lipoblastomas in pediatric patients and to differentiate them from other palpable benign lipomatous tumors.
  • The relatively specific MRI features of nonenhancing cystic change and enhancing soft tissue nodules seen in lipoblastoma may help to differentiate it from other types of lipomatous tumor in pediatric patients.
  • [MeSH-major] Lipoma / diagnosis. Magnetic Resonance Imaging / methods. Palpation. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Child. Child, Preschool. Diagnosis, Differential. Female. Humans. Infant. Male

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 21092875.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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72. Li H, Fan X, Kovi RC, Jo Y, Moquin B, Konz R, Stoicov C, Kurt-Jones E, Grossman SR, Lyle S, Rogers AB, Montrose M, Houghton J: Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res; 2007 Nov 15;67(22):10889-98
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  • Based on the facts that mesenchymal stem cells (MSC) transform with higher frequency than other cell types, and tumors in aged C57BL/6 mice are frequently fibrosarcomas, we used a genetically tagged bone marrow (BM) transplant model to show that aged mice develop MSC-derived fibrosarcomas.
  • Spontaneously transformed MSCs contribute directly to the tumor, tumor vasculature, and tumor adipose tissue, recruit additional host BM-derived cells (BMDC) to the area, and fuse with the host BMDC.
  • Unfused transformed MSCs act as the cancer stem cell and are able to form tumors in successive mice, whereas fusion restores a nonmalignant phenotype.
  • These data suggest that MSCs may play a key role in age-related tumors, and fusion with host cells restores a nonmalignant phenotype, thereby providing a mechanism for regulating tumor cell activity.


73. Guo J, Zhou S, Rao NP, Pez GH: Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. Appl Immunohistochem Mol Morphol; 2010 Oct;18(5):473-8
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  • Pleomorphic malignant fibrous histiocytoma (MFH), also known as undifferentiated high-grade pleomorphic sarcoma according to the latest World Health Organization classification, is a diagnosis of exclusion and extremely rare in adult scrotal/paratesticular region.
  • Fluorescence in-situ hybridization showed an aneuploid karyotype and negative results for lipomatous tumor abnormalities.
  • The diagnosis of scrotal/paratesticular pleomorphic MFH with concurrent Fournier gangrene was made.


74. Panzarella MJ, Naqvi AH, Cohen HE, Damron TA: Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors. Skeletal Radiol; 2005 May;34(5):272-8
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  • [Title] Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors.
  • OBJECTIVE: To determine the predictive value of gadolinium enhancement on MRI in differentiating atypical lipomatous tumor (ALT)/well-differentiated (WD) liposarcoma from benign fatty tumors.
  • DESIGN: All histologically proven fatty tumors with preoperative gadolinium-enhanced MRI were reviewed.
  • Only those tumors with predominantly fatty signal were included.
  • Sensitivity, specificity, and positive and negative predictive values for both gadolinium enhancement and biopsy as predictors for the final diagnosis of ALT/WD liposarcoma were calculated.
  • PATIENTS: From 129 patients evaluated for fatty tumors between 1994 and 2002, the patient population was narrowed to 32 excised fatty tumors with preoperative gadolinium-enhanced MRI.
  • Needle or incisional biopsy yielded 57% sensitivity, 100% specificity, 100% positive predictive value and 63% negative predictive value for a diagnosis of ALT/WD liposarcoma.
  • CONCLUSIONS: Gadolinium enhancement of a homogeneous fatty soft tissue tumor is a sensitive screening tool to determine possible diagnosis of ALT/WD liposarcoma.
  • [MeSH-major] Contrast Media. Gadolinium. Lipoma / diagnosis. Liposarcoma / diagnosis. Magnetic Resonance Imaging
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Predictive Value of Tests. Sensitivity and Specificity

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  • (PMID = 15742204.001).
  • [ISSN] 0364-2348
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Contrast Media; AU0V1LM3JT / Gadolinium
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75. Anaya DA, Lahat G, Wang X, Xiao L, Tuvin D, Pisters PW, Lev DC, Pollock RE: Establishing prognosis in retroperitoneal sarcoma: a new histology-based paradigm. Ann Surg Oncol; 2009 Mar;16(3):667-75
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  • BACKGROUND: Retroperitoneal sarcoma (RPS) American Joint Committee on Cancer (AJCC) staging applies to primary tumors only; due to specific RPS disease characteristics, staging is driven primarily by grade, stratifying patients into only two distinct prognostic subsets.
  • METHODS: A RPS database of 1,118 patients seen at our institution (1996-2006) identified 343 patients treated for resectable primary or recurrent disease; a histologic subtype-based RPS prognostic system was designed and evaluated for prognostic accuracy in comparison with the current AJCC staging system.
  • RESULTS: Histology stratified patients into three groups by prognosis (P<0.0002): atypical lipomatous tumor (ALT), non-ALT liposarcoma (LPS), and "other," an improvement compared with AJCC staging which could only identify two distinct prognostic groups.
  • Distinct risk stratification is critical for specific assessment of prognosis as well as decisions regarding individualized adjuvant therapies, hence the advantage of a three-tiered histology-based system applicable in both primary and recurrent RPS.
  • [MeSH-major] Neoplasm Recurrence, Local / pathology. Retroperitoneal Neoplasms / pathology. Sarcoma / pathology

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  • (PMID = 19101765.001).
  • [ISSN] 1534-4681
  • [Journal-full-title] Annals of surgical oncology
  • [ISO-abbreviation] Ann. Surg. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Giannopoulou I, Fernhall B, Carhart R, Weinstock RS, Baynard T, Figueroa A, Kanaley JA: Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes. Metabolism; 2005 Jul;54(7):866-75
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  • Plasma resistin levels were not altered by the 3 interventions from pre- to posttreatment (D: pre = 6.9 +/- 0.6, post = 6.2 +/- 0.4 ng/mL; D + E: pre = 5.6 +/- 0.6, post = 5.7 +/- 0.4 ng/mL; E: pre = 6.2 +/- 0.6, post = 5.9 +/- 0.6 ng/mL, P > .05), and no differences in adiponectin and tumor necrosis factor alpha (TNF- alpha ) levels were found.
  • Visceral adipose tissue and tumor necrosis factor alpha were the only predictors of calculated insulin resistance ( P < .05), explaining 43% of the variability.


77. Kumazoe H, Nagamatsu Y, Nishi T, Kimura YN, Nakazono T, Kudo S: Dumbbell-shaped thoracic hibernoma: computed tomography and magnetic resonance imaging findings. Jpn J Radiol; 2009 Jan;27(1):37-40
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  • Hibernoma is an uncommon, benign soft tissue tumor that arises in brown adipose tissue.
  • We report the unique appearance of a rare thoracic wall hibernoma, which appeared as a dumbbell-shaped lipomatous tumor across an intercostal region.
  • [MeSH-major] Lipoma / radiography. Soft Tissue Neoplasms / radiography

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  • (PMID = 19373530.001).
  • [ISSN] 1867-1071
  • [Journal-full-title] Japanese journal of radiology
  • [ISO-abbreviation] Jpn J Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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78. Adachi S, Kawamura N, Hatano K, Kakuta Y, Takada T, Hara T, Yamaguchi S: Lipomatous ganglioneuroma of the retroperitoneum. Pathol Int; 2008 Mar;58(3):183-6
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  • [Title] Lipomatous ganglioneuroma of the retroperitoneum.
  • A unique case of ganglioneuroma mimicking a lipomatous tumor in a 73-year-old man is reported.
  • The tumor was incidentally found on radiography performed for unrelated reasons.
  • The laparotomy indicated that the tumor was located on the right adrenal gland.
  • It was well circumscribed but not encapsulated, and was approximately 2 cm in diameter.
  • Microscopically, ganglioneuromatous component was scattered in the background of a large amount of adipose tissue.
  • Because the presence of such a large amount of adipose tissue seems to be rare in ganglioneuromas, its histogenesis is discussed.
  • [MeSH-major] Adipose Tissue / pathology. Ganglioneuroma / diagnosis. Myelolipoma / diagnosis. Retroperitoneal Neoplasms / diagnosis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Chromogranins / analysis. Diagnosis, Differential. Glial Fibrillary Acidic Protein / analysis. Humans. Immunohistochemistry. Male. S100 Proteins / analysis. Synaptophysin / analysis

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  • (PMID = 18251782.001).
  • [ISSN] 1440-1827
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Chromogranins; 0 / Glial Fibrillary Acidic Protein; 0 / S100 Proteins; 0 / Synaptophysin
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79. Cappellani A, Zanghì A, Di Vita M, La Porta D, Alfano G, D'Angelo AF: Very atypical presentation of a retroperitoneal "atypical lipoma". A well differentiated liposarcoma presenting as sciatic hernia. Ann Ital Chir; 2007 Jan-Feb;78(1):69-72
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  • [Title] Very atypical presentation of a retroperitoneal "atypical lipoma". A well differentiated liposarcoma presenting as sciatic hernia.
  • Unlike hernias and neoplasms of any other body site, the sciatic hernia is uncommon and the finding of an atypical lipoma in it is probably unique.
  • In such instance making the correct diagnosis is paramount in order to perform a procedure with a radical intent.
  • A CT scan must be considered any time a rare form of hernia is observed and the surgical treatment of a retroperitoneal lipoma has to be radical, to prevent a recurrence.
  • This is the strategy followed by the authors in a case of a 53 year old lady presenting with a large retroperitoneal lipomatous neoplasm within a sciatic hernia.
  • [MeSH-major] Hernia / etiology. Lipoma / diagnosis. Liposarcoma / diagnosis. Retroperitoneal Neoplasms / diagnosis. Sciatic Nerve
  • [MeSH-minor] Diagnosis, Differential. Female. Herniorrhaphy. Humans. Middle Aged. Treatment Outcome


80. Weaver J, Rao P, Goldblum JR, Joyce MJ, Turner SL, Lazar AJ, López-Terada D, Tubbs RR, Rubin BP: Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Mod Pathol; 2010 Oct;23(10):1301-6
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  • Well-differentiated liposarcoma/atypical lipomatous tumor can be difficult to differentiate from benign lipomatous tumors, especially on limited biopsy material.
  • Adjunctive tests for MDM2 (murine double minute 2) have proven useful in whole-tissue sections; however, their utility has not been determined within the increasingly popular core needle biopsy.
  • Herein, we compare the ability of MDM2 immunohistochemistry and MDM2 fluorescence in situ hybridization (FISH) to discriminate benign lipomatous tumors from well-differentiated liposarcoma on core needle biopsies.
  • Well-differentiated liposarcoma (n=17) and an assortment of benign lipomatous tumors (n=37), which had concurrent or previous core needle biopsies, and resection specimens were subjected to both MDM2 immunohistochemistry and MDM2 FISH on both whole-tissue sections and corresponding core needle biopsy sections.
  • Percentage tumor cells positive for MDM2 by immunohistochemistry and an MDM2:CEP12 FISH ratio was calculated in each biopsy and resection specimen pair and the results were compared.
  • The average MDM2:CEP12 ratio was similar in the biopsy material compared with the whole-tissue sections in both well-differentiated liposarcoma and the benign lipomatous tumor group of neoplasms.
  • Detection of MDM2 amplification by FISH is a more sensitive and specific adjunctive test than MDM2 immunohistochemistry to differentiate well-differentiated liposarcoma from various benign lipomatous tumors, especially on limited tissue samples.
  • [MeSH-major] Biomarkers, Tumor / analysis. Biopsy, Needle. Liposarcoma / diagnosis. Proto-Oncogene Proteins c-mdm2 / biosynthesis
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Lipoma / diagnosis. Sensitivity and Specificity


81. Dutton JJ, Wright JD Jr: Intramuscular lipoma of the superior oblique muscle. Orbit; 2006 Sep;25(3):227-33
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  • We describe a rare intramuscular infiltrating lipomatous tumor affecting the superior oblique muscle.
  • Biopsy showed an infiltrative tumor consisting of adipocytes with included degenerated muscle fibers.
  • Lipomas are common tumors that usually do not cause functional impairment but are very rare in the orbit.
  • Enlargement of an extraocular or periorbital muscle with a low-density infiltrating lesion should raise suspicion for this unusual tumor.
  • [MeSH-major] Lipoma / pathology. Muscle Neoplasms / pathology. Oculomotor Muscles

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  • (PMID = 16987771.001).
  • [ISSN] 0167-6830
  • [Journal-full-title] Orbit (Amsterdam, Netherlands)
  • [ISO-abbreviation] Orbit
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
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82. Shimada S, Harada H, Ishizawa K, Hirose T: Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma. Pathol Int; 2006 Oct;56(10):638-41
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  • [Title] Retroperitoneal lipomatous angiomyolipoma associated with amyloid deposition masquerading as well-differentiated liposarcoma.
  • A 16 x 13 cm lipomatous tumor was resected from the perirenal retroperitoneum of a 71-year-old woman.
  • Microscopically, the tumor was exclusively composed of mature adipose tissue and abnormal thick blood vessels, but bundles of smooth muscle were lacking.
  • Real-time polymerase chain reaction failed to demonstrate the amplification of the murine double-minute type 2 gene and cyclin-dependent kinase 4 gene in this tumor.
  • Therefore, the tumor was diagnosed as lipomatous angiomyolipoma.
  • After the diagnosis, it was found that the patient had multiple myeloma and cardiac amyloidosis, suggesting that the amyloid deposition within the tumor was a complication of the myeloma.
  • Lipomatous angiomyolipoma may be a diagnostic pitfall of retroperitoneal lipomatous tumors.
  • [MeSH-major] Amyloid / metabolism. Angiomyolipoma / diagnosis. Angiomyolipoma / metabolism. Liposarcoma / diagnosis. Liposarcoma / metabolism. Retroperitoneal Neoplasms / diagnosis. Retroperitoneal Neoplasms / metabolism
  • [MeSH-minor] Aged. Cyclin-Dependent Kinase 4 / genetics. Cyclin-Dependent Kinase 4 / metabolism. Diagnosis, Differential. Female. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Humans. Proto-Oncogene Proteins c-mdm2 / genetics. Proto-Oncogene Proteins c-mdm2 / metabolism

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  • (PMID = 16984623.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Amyloid; EC 2.7.11.22 / Cyclin-Dependent Kinase 4; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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83. Chen E, Fletcher CD: Cellular angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. Am J Surg Pathol; 2010 May;34(5):707-14
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  • Cellular angiofibroma is a mesenchymal neoplasm that is characterized by a bland spindle cell component, morphologically reminiscent of spindle cell lipoma, and thick-walled vessels.
  • The tumor occurs equally in men and women and usually arises in the inguino-scrotal or vulvovaginal regions.
  • An earlier study of 51 cases from our group showed that the tumor follows a benign course without any tendency for recurrence.
  • In this study, we characterized clinicopathologic features in 13 cases of cellular angiofibroma with morphologic atypia or sarcomatous transformation.
  • Tumor size ranged from 1.2 to 7.5 cm.
  • In 11 cases, the tumors occurred in the vulva.
  • Most tumors were located in subcutaneous tissue.
  • There were 9 cases of cellular angiofibroma with morphologic features of sarcomatous transformation.
  • Three of these 9 cases showed discrete nodule(s) closely resembling atypical lipomatous tumor within usual cellular angiofibroma.
  • The 3 cases with atypical lipomatous tumor-like areas were negative for MDM-2 and CDK4.
  • Six patients did not develop recurrence or metastasis.
  • One patient died of metastatic carcinoma of unknown primary site 27 months after the diagnosis of cellular angiofibroma with sarcomatous transformation.
  • Cellular angiofibroma with atypia or morphologic sarcomatous transformation occurs predominantly in the subcutaneous tissue of the vulva and, as yet, shows no evident tendency to recur based on limited clinical follow-up available for 7 cases.
  • The sarcomatous component can show variable features including atypical lipomatous tumor, pleomorphic liposarcoma, and pleomorphic sarcoma NOS.
  • [MeSH-major] Angiofibroma / pathology. Cell Transformation, Neoplastic. Sarcoma / pathology. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / analysis. Female. Humans. Male. Middle Aged. Vulva / pathology. Vulvar Neoplasms / chemistry. Vulvar Neoplasms / pathology. Vulvar Neoplasms / surgery

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  • (PMID = 20305534.001).
  • [ISSN] 1532-0979
  • [Journal-full-title] The American journal of surgical pathology
  • [ISO-abbreviation] Am. J. Surg. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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84. Xu Y, Wang J, Peng Y, Zeng J: CT characteristics of primary retroperitoneal neoplasms in children. Eur J Radiol; 2010 Sep;75(3):321-8
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  • [Title] CT characteristics of primary retroperitoneal neoplasms in children.
  • Primary retroperitoneal neoplasms are uncommon in children.
  • Retroperitoneal neoplasms are either mesodermal, neurogenic, germ cell ectodermal or lymphatic in origin.
  • In general, primary retroperitoneal neoplasms in children have different spectrum and prevalence compared to those in adults.
  • Neuroblastoma, rhabdomyosarcoma, benign teratoma and lymphoma are the common retroperitoneal neoplasms.
  • In this review, the clinical and CT futures of common retroperitoneal neoplasms in children are described.
  • In children, lipoblastoma is the most common lipomatous tumor in the retroperitoneum.
  • The percentage of visible fat in tumor varies depending on the cellular composition of the lesion.
  • In conclusion, making a final histological diagnosis of retroperitoneal tumor base on CT features is not often possible; however, CT can help to develop a differential diagnosis and determine the size and extent of the retroperitoneal neoplasms.
  • [MeSH-major] Retroperitoneal Neoplasms / radiography. Tomography, X-Ray Computed / methods

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  • [Copyright] Copyright © 2010. Published by Elsevier Ireland Ltd.
  • (PMID = 20591598.001).
  • [ISSN] 1872-7727
  • [Journal-full-title] European journal of radiology
  • [ISO-abbreviation] Eur J Radiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
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85. Aust MC, Spies M, Kall S, Jokuszies A, Gohritz A, Vogt P: Posttraumatic lipoma: fact or fiction? Skinmed; 2007 Nov-Dec;6(6):266-70
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  • Lipomas are usually benign adipose tumors with as-yet unexplained pathogenesis and etiology.
  • A link between soft tissue trauma and the formation of lipomas has been described, with the latter being named posttraumatic lipomas.
  • The average time between soft tissue trauma and lipoma formation was 2.6 years (range, 0.5-6.0 years).
  • All tumors were located epifascially.
  • Pathology demonstrated capsulated and noncapsulated benign adipose tumors in 23 cases.
  • CONCLUSIONS: The pathogenetic link between soft tissue trauma and the formation of posttraumatic lipomas is still controversially discussed.
  • There are 2 potential explanations to correlate soft tissue trauma and adipose tissue tumor growth.
  • The first is the formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact.
  • A second possibility points toward lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation.
  • [MeSH-major] Adipose Tissue / injuries. Lipoma / etiology. Neoplasms, Adipose Tissue / etiology. Wounds, Nonpenetrating / complications

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  • (PMID = 17975353.001).
  • [ISSN] 1540-9740
  • [Journal-full-title] Skinmed
  • [ISO-abbreviation] Skinmed
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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86. Browne TJ, Fletcher CD: Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity. Histopathology; 2006 Mar;48(4):453-61
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  • [Title] Haemosiderotic fibrolipomatous tumour (so-called haemosiderotic fibrohistiocytic lipomatous tumour): analysis of 13 new cases in support of a distinct entity.
  • AIMS: To describe 13 new cases of a rare soft tissue neoplasm currently known as haemosiderotic fibrohistiocytic lipomatous tumour (HFHLL) and to further its characterization.
  • Grossly the lesions were fatty/gelatinous or lipoma-like.
  • Dissecting between adipocytic lobules were septa containing short spindle cells with streaming, swirling or honeycomb growth patterns.
  • CONCLUSIONS: So-called HFHLL, better termed haemosiderotic fibrolipomatous tumour, is a distinct lesion characterized by an admixture of fibroblastic spindle cells, mature adipocytes and haemosiderin pigmentation, shows a predilection for the distal extremities and quite often recurs locally.
  • [MeSH-major] Hemosiderosis / pathology. Histiocytoma, Benign Fibrous / pathology. Lipoma / pathology. Soft Tissue Neoplasms / pathology

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  • (PMID = 16487368.001).
  • [ISSN] 0309-0167
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, CD34; 9011-92-1 / Hemosiderin
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87. Colella G, Biondi P, Caltabiano R, Vecchio GM, Amico P, Magro G: Giant intramuscular lipoma of the tongue: a case report and literature review. Cases J; 2009;2:7906
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  • A 75-year-old Italian male presented at our department with a large tumor at the tip of the tongue that had been present for over 30 years.
  • Histological examination showed an unencapsulated lipomatous tumor composed of mature adipocytes, uniform in size and shape, diffusely infiltrating striated muscle fibers of the tongue.

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  • [Cites] J Oral Maxillofac Surg. 1991 Nov;49(11):1231-6 [1941342.001]
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  • (PMID = 19830025.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3302006
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88. Ferrari G, Paci M, Sgarbi G: Thymolipoma of the anterior mediastinum: videothoracoscopic removal using a bilateral approach. Thorac Cardiovasc Surg; 2006 Sep;54(6):435-7
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  • Thymolipoma, a rare benign neoplasm of the anterior mediastinum, is often asymptomatic and as a result it can become quite large before it is diagnosed.
  • CT is the most accurate diagnostic technique to identify the adipose tissue, but it often cannot make a differential diagnosis differentiating it from other anterior mediastinal masses; transthoracic biopsy also reveals the presence of fatty tissue, but a definitive diagnosis can only be achieved by means of surgical excision, which is also curative.
  • We describe the case of a young woman who presented with a fatty neoplasm of the anterior mediastinum.
  • The histopathological diagnosis was thymolipoma.
  • [MeSH-major] Lipoma / surgery. Mediastinal Neoplasms / surgery. Thoracic Surgery, Video-Assisted. Thymus Neoplasms / surgery

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  • (PMID = 16967386.001).
  • [ISSN] 0171-6425
  • [Journal-full-title] The Thoracic and cardiovascular surgeon
  • [ISO-abbreviation] Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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89. Erickson-Johnson MR, Seys AR, Roth CW, King AA, Hulshizer RL, Wang X, Asmann YW, Lloyd RV, Jacob EK, Oliveira AM: Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. Mod Pathol; 2009 Dec;22(12):1541-7
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  • The discrimination between well-differentiated liposarcomas/atypical lipomatous tumors and lipomas can be diagnostically challenging at the histological level.
  • However, cytogenetic identification of ring and giant rod chromosomes supports the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumor.
  • MDM2 is consistently amplified in well-differentiated liposarcomas/atypical lipomatous tumors, and up to 25% in other sarcomas.
  • As part of a large genomic study of lipomatous neoplasms, we initially found CPM to be consistently amplified in well-differentiated liposarcomas/atypical lipomatous tumors.
  • To further explore this initial finding, we investigated the copy number status of MDM2 and CPM by fluorescent in situ hybridization (FISH) on a series of 138 tumors and 17 normal tissues, including 32 well-differentiated liposarcoma/atypical lipomatous tumors, 63 lipomas, 11 pleomorphic lipomas, 2 lipoblastomas, 30 other tumors and 17 normal fat samples.
  • All 32 well-differentiated liposarcoma/atypical lipomatous tumors showed amplification of MDM2 and CPM, usually >20 copies per cell.
  • The other tumors lacked MDM2 and/or CPM amplification.
  • Chromogenic in situ hybridization confirmed the above results on a subset of these tumors (n=27).
  • These findings suggest that identification of CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors.
  • [MeSH-major] Biomarkers, Tumor / genetics. Cell Differentiation. Gene Amplification. Lipoma / diagnosis. Liposarcoma / diagnosis. Metalloendopeptidases / genetics
  • [MeSH-minor] Comparative Genomic Hybridization. Diagnosis, Differential. GPI-Linked Proteins. Gene Dosage. Gene Expression Regulation, Enzymologic. Gene Expression Regulation, Neoplastic. Genetic Testing. Humans. In Situ Hybridization, Fluorescence. Predictive Value of Tests. Proto-Oncogene Proteins c-mdm2 / genetics

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  • (PMID = 19820690.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / GPI-Linked Proteins; EC 3.4.17.12 / carboxypeptidase M; EC 3.4.24.- / Metalloendopeptidases; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
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90. Weaver J, Goldblum JR, Turner S, Tubbs RR, Wang WL, Lazar AJ, Rubin BP: Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma. Mod Pathol; 2009 Jan;22(1):66-70
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  • Inflammatory liposarcoma is a variant of well-differentiated liposarcoma/atypical lipomatous tumor that consists of a mixture of lymphocytes, histiocytes, scattered atypical stromal cells, mature adipocytes, and rarely lipoblasts.
  • When the inflammatory infiltrate predominates, the morphological features overlap with various fibroinflammatory disorders including sclerosing mesenteritis and retroperitoneal fibrosis, making the diagnosis difficult.
  • Well-differentiated liposarcoma/atypical lipomatous tumor and dedifferentiated liposarcoma have characteristic molecular markers in the form of giant marker and ring chromosomes consisting of amplicons of 12q13-15, which includes MDM2.
  • [MeSH-major] Biomarkers, Tumor / genetics. Liposarcoma / diagnosis. Panniculitis, Peritoneal / diagnosis. Proto-Oncogene Proteins c-mdm2 / genetics. Retroperitoneal Fibrosis / diagnosis
  • [MeSH-minor] Diagnosis, Differential. Gene Amplification. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Inflammation / diagnosis. Inflammation / genetics. Sensitivity and Specificity


91. de Saint Aubain Somerhausen N, Coindre JM, Debiec-Rychter M, Delplace J, Sciot R: Lipoblastoma in adolescents and young adults: report of six cases with FISH analysis. Histopathology; 2008 Feb;52(3):294-8
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  • AIMS: Lipoblastoma is a rare benign adipocytic neoplasm that occurs primarily in infancy and early childhood.
  • Histologically, there is some morphological overlap with atypical lipomatous tumour and myxoid liposarcoma and the age at presentation is often regarded as a major diagnostic criterion.
  • CONCLUSIONS: Lipoblastoma occurs rarely in young adults and should enter into the differential diagnosis of 'atypical' fatty tumours in adults.
  • [MeSH-major] DNA, Neoplasm / analysis. In Situ Hybridization, Fluorescence. Lipoma / genetics. Lipoma / pathology. Soft Tissue Neoplasms / genetics. Soft Tissue Neoplasms / pathology
  • [MeSH-minor] Adipocytes / pathology. Adolescent. Adult. Chromosome Aberrations. Disease-Free Survival. Female. Humans. Male. Neoplasm Recurrence, Local

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  • (PMID = 18269579.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
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92. Titiz A, Yilmaz YF, Ceyhan S, Unal T: Atypical lipomatous tumor in the submental region. J Craniofac Surg; 2008 Nov;19(6):1558-60
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  • [Title] Atypical lipomatous tumor in the submental region.
  • A 54-year-old male patient presented to our outpatient clinic complaining of a mass under his chin, which appeared nearly 1 year earlier.
  • Pathologic diagnosis was atypical lipomatous tumor.
  • Atypical lipomatous tumors/well-differentiated liposarcomas are rarely reported in the head and neck.
  • We review the clinical and management features of atypical lipomatous tumors.
  • [MeSH-major] Head and Neck Neoplasms / diagnosis. Liposarcoma / diagnosis
  • [MeSH-minor] Adipocytes / pathology. Biomarkers, Tumor / analysis. Biopsy, Fine-Needle. Cell Nucleus / ultrastructure. Contrast Media. Humans. Male. Middle Aged. Proto-Oncogene Proteins c-mdm2 / analysis. S100 Proteins / analysis. Stromal Cells / pathology. Tomography, X-Ray Computed

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  • (PMID = 19098551.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Contrast Media; 0 / S100 Proteins; EC 6.3.2.19 / MDM2 protein, human; EC 6.3.2.19 / Proto-Oncogene Proteins c-mdm2
  • [Number-of-references] 13
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93. Fernández-Sueiro JL, Pinto JA, Blanco FJ, Freire M, Veiga JA, Galdo F, González-Gay MA: Multiple parosteal lipoma associated to polyarthritis. Joint Bone Spine; 2006 Mar;73(2):202-4
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  • Parosteal lipoma is a benign adipose tissue tumor situated directly in the bone cortex.
  • We describe a patient who presented with polyarthritis associated with multiple parosteal lipomatous involvement.
  • A tissue sample from the distal portion of the forearm confirmed the presence of cumulative fat tissue with nodes of esteatonecrosis.
  • [MeSH-major] Arthritis / etiology. Bone Neoplasms / complications. Lipoma / complications. Periosteum / pathology
  • [MeSH-minor] Adipose Tissue / pathology. Anti-Inflammatory Agents, Non-Steroidal / therapeutic use. Drug Therapy, Combination. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Prednisone / therapeutic use. Tomography, X-Ray Computed. Wrist / pathology. Wrist / radiography

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  • (PMID = 16226479.001).
  • [ISSN] 1297-319X
  • [Journal-full-title] Joint, bone, spine : revue du rhumatisme
  • [ISO-abbreviation] Joint Bone Spine
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents, Non-Steroidal; VB0R961HZT / Prednisone
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94. Calò PG, Farris S, Tatti A, Tuveri M, Catani G, Nicolosi A: Primary mesenteric liposarcoma. Report of a case. G Chir; 2007 Aug-Sep;28(8-9):318-20
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  • [Title] Primary mesenteric liposarcoma. Report of a case.
  • Primary mesenteric liposarcomas are very rare neoplasms.
  • Surgical excision with a tumour-free margin was achieved.
  • The histologic appearances were those of a well-differentiated liposarcoma (atypical lipomatous tumour).
  • The patient is alive and disease-free 33 months after the surgery.
  • Primary mesenteric liposarcoma is often resectable and requires aggressive surgical management; in consideration of the high risk of tumour recurrence, the treatment of choice is a wide surgical excision.
  • [MeSH-minor] Adult. Female. Humans. Peritoneal Neoplasms / diagnosis

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  • (PMID = 17785044.001).
  • [ISSN] 0391-9005
  • [Journal-full-title] Il Giornale di chirurgia
  • [ISO-abbreviation] G Chir
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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95. Siddiqui MK, Jyoti, Singh S, Mehrotra PK, Singh K, Sarangi R: Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study. Environ Int; 2006 Jul;32(5):630-7
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  • [Title] Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: an Indian study.
  • Fifty women residing in and around New Delhi, India and identified to have benign (25 nos.) and malignant (25 nos.) breast lesions were studied for the first time to access the association between environmental exposure to lead and risk of breast cancer and to determine the potential of changes in trace elements concentration as a diagnostic marker and/or its etiological involvement in the disease.
  • Blood, tumor tissue and breast adipose tissue from tumor free area from each patient of the two groups, collected at the time of lumpectomy or mastectomy (only blood sample was collected from disease free control group), were analyzed to determine the concentration of Pb, Zn, Cu, Fe and Ca using Atomic Absorption Spectrometry.
  • Lead level was also higher in tumor tissue when compared with their respective normal tumor free breast tissue, though non-significant, in both benign and malignant cases.
  • Furthermore, these metals were also higher in tumor of malignant and benign cases as compared to normal tumor free breast tissue, many of them statistically significant (p<0.05/0.01/0.001).
  • However, Cu level was insignificantly lower in the blood and tumor tissue of malignant cases when compared with their benign counterparts while it was significantly higher (p<0.05) in tumor of benign cases when compared with those of their respective normal tumor free breast tissue.
  • There were statistically significant correlations between lead and trace element levels only in normal tumor free breast tissue of benign and malignant cases (r=0.41-0.73; p<0.05-0.001) but neither in blood nor tumor tissue of the two groups.
  • Further, modulation of trace elements level in both benign and malignant breast diseases patients may be of potential to be used as diagnostic marker of the disease process and its possible relationship etiologically.
  • [MeSH-major] Biomarkers, Tumor / blood. Breast Neoplasms / blood. Mammary Glands, Human / metabolism. Trace Elements / blood

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  • (PMID = 16580070.001).
  • [ISSN] 0160-4120
  • [Journal-full-title] Environment international
  • [ISO-abbreviation] Environ Int
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Trace Elements
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96. Svegliati-Baroni G, Candelaresi C, Saccomanno S, Ferretti G, Bachetti T, Marzioni M, De Minicis S, Nobili L, Salzano R, Omenetti A, Pacetti D, Sigmund S, Benedetti A, Casini A: A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol; 2006 Sep;169(3):846-60
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  • [Title] A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.
  • Insulin resistance induces nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH).
  • We used a high-fat, high-calorie solid diet (HFD) to create a model of insulin resistance and NASH in nongenetically modified rats and to study the relationship between visceral adipose tissue and liver.
  • Obesity and insulin resistance occurred in HFD rats, accompanied by a progressive increase in visceral adipose tissue tumor necrosis factor (TNF)-alpha mRNA and in circulating free fatty acids.
  • HFD also decreased adiponectin mRNA and peroxisome proliferator-activated receptor (PPAR)-alpha expression in the visceral adipose tissue and the liver, respectively, and induced hepatic insulin resistance through TNF-alpha-mediated c-Jun N-terminal kinase (JNK)-dependent insulin receptor substrate-1Ser307 phosphorylation.
  • Supplementation of n-3 polyunsaturated fatty acid, a PPARalpha ligand, to HFD-treated animals restored hepatic adiponectin and PPARalpha expression, reduced TNF-alpha hepatic levels, and ameliorated fatty liver and the degree of liver injury.
  • Thus, our model mimics the most common features of NASH in humans and provides an ideal tool to study the role of individual pathogenetic events (as for PPARalpha down-regulation) and to define any future experimental therapy, such as n-3 polyunsaturated fatty acid, which ameliorated the degree of liver injury.
  • [MeSH-major] Fatty Acids, Omega-3 / metabolism. Fatty Liver / metabolism. Insulin Resistance. Intra-Abdominal Fat / metabolism. Liver / metabolism
  • [MeSH-minor] Animals. Apoptosis. Disease Models, Animal. Down-Regulation. Fibrosis / metabolism. Fibrosis / pathology. Food, Formulated / adverse effects. Hepatocytes / metabolism. Hepatocytes / pathology. Humans. Insulin Receptor Substrate Proteins. JNK Mitogen-Activated Protein Kinases / metabolism. Male. Necrosis / metabolism. Necrosis / pathology. Oxidative Stress. Phosphoproteins / metabolism. Protein Processing, Post-Translational. RNA, Messenger / biosynthesis. Rats. Rats, Sprague-Dawley. Tumor Necrosis Factor-alpha / biosynthesis

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  • (PMID = 16936261.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Fatty Acids, Omega-3; 0 / IRS1 protein, human; 0 / Insulin Receptor Substrate Proteins; 0 / Irs1 protein, rat; 0 / Phosphoproteins; 0 / RNA, Messenger; 0 / Tumor Necrosis Factor-alpha; EC 2.7.11.24 / JNK Mitogen-Activated Protein Kinases
  • [Other-IDs] NLM/ PMC1698833
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97. Casanova Espinosa A, Cisneros Serrano C, Girón Moreno RM, Olivera MJ, Moreno Balsalobre R, Zamora García E: [Pleural empyema associated with endobronchial lipoma]. Arch Bronconeumol; 2005 Mar;41(3):172-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Bronchial benign tumors comprise fewer than 4% of pulmonary neoplasms.
  • Endobronchial lipoma is an extremely rare benign neoplasm accounting for only 0.1% to 0.5% of all lung tumors.
  • Clinical symptoms of lipoma depend on the location of the tumor, the severity of bronchial obstruction, and the functional and anatomical effects on the parenchyma distal to the obstruction.
  • Computed axial tomography usually reveals the adipose composition of the lipomatous tumor.
  • We report the case of an 83-year-old man diagnosed with community-acquired pneumonia that led to complications: pleural empyema caused by Haemophilus influenzae infection and atelectasis of the right middle and lower lobes secondary to a lipomatous endobronchial obstruction.
  • [MeSH-major] Bronchial Neoplasms / complications. Empyema, Pleural / etiology. Lipoma / complications

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  • (PMID = 15766470.001).
  • [ISSN] 0300-2896
  • [Journal-full-title] Archivos de bronconeumología
  • [ISO-abbreviation] Arch. Bronconeumol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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98. Aftab S, Casey A, Tirabosco R, Kabir SR, Saifuddin A: Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review. Skeletal Radiol; 2010 Oct;39(10):1039-42
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Fat-forming solitary fibrous tumour (lipomatous haemangiopericytoma) of the spine: case report and literature review.
  • Solitary fibrous tumour (SFT) is a rare soft tissue tumour of uncertain histogenesis and unpredictable biological behaviour, which was first described in the pleura and subsequently in many extra-pleural locations.
  • We present the clinical, radiological and histological features of a case of intraspinal fat-forming SFT, along with a literature review.
  • This is the first known report of a fat-forming SFT in the spine.
  • [MeSH-major] Solitary Fibrous Tumors / diagnosis. Spinal Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Follow-Up Studies. Hemangiopericytoma / diagnosis. Hemangiopericytoma / surgery. Humans. Lipoma / diagnosis. Lipoma / surgery. Magnetic Resonance Imaging / methods. Male. Rectal Neoplasms / diagnosis. Rectal Neoplasms / surgery. Treatment Outcome

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  • (PMID = 20628877.001).
  • [ISSN] 1432-2161
  • [Journal-full-title] Skeletal radiology
  • [ISO-abbreviation] Skeletal Radiol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] Lipomatous hemangiopericytoma
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99. Mentzel T, Toennissen J, Rütten A, Schaller J: Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location. Virchows Arch; 2005 Mar;446(3):300-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Palmar atypical lipomatous tumour with spindle cell features (well-differentiated spindle cell liposarcoma): a rare neoplasm arising in an unusual anatomical location.
  • Lipomatous tumours, both benign and malignant, arising on the hands are uncommon.
  • We present a rare atypical lipomatous tumour with spindle cell features (synonym: well-differentiated spindle cell liposarcoma) arising on the left palm of a 54-year-old male patient.
  • The neoplasm presented as a long-standing, exophytic neoplasm measuring 9 x 9 cm.
  • The well-circumscribed neoplasm was completely excised, and margins were tumour free.
  • Histologically, the neoplasm showed features closely resembling spindle cell lipoma, being composed of mature adipocytic cells associated with bland, neuroid spindle cells staining positively for CD34.
  • However, focally, atypia of adipocytic and stromal cells as well as scattered lipoblasts were noted, and immunohistochemical stainings showed focal overexpression of MDM 2 and CDK4.
  • Aypical lipomatous tumour with spindle cell features may arise very rarely in palmar location and has to be distinguished from a number of benign and malignant mesenchymal neoplasms.
  • [MeSH-minor] Diagnosis, Differential. Humans. Immunohistochemistry. Male. Middle Aged

  • Genetic Alliance. consumer health - Liposarcoma.
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  • (PMID = 15719245.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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100. Fimmanò A, Coppola Bottazzi E, Cirillo C, Tammaro P, Casazza D: [Giant atypical muscle-involving lipoma of the right thigh: a case report and review of the literature]. Chir Ital; 2005 Nov-Dec;57(6):773-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Ultrasonography confirmed the presence of the tumefaction but did not allow us to identify its origin with certainty.
  • The histological findings indicated an atypical lipomatous tumour.
  • [MeSH-major] Lipoma. Soft Tissue Neoplasms. Thigh

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  • (PMID = 16400775.001).
  • [ISSN] 0009-4773
  • [Journal-full-title] Chirurgia italiana
  • [ISO-abbreviation] Chir Ital
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 14
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