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1. Whitt JC, Schafer DR, Callihan MD: Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth. Head Neck Pathol; 2008 Mar;2(1):41-8
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  • [Title] Multiple malignant salivary gland neoplasms: mucoepidermoid carcinoma of palate and adenoid cystic carcinoma of floor of mouth.
  • Salivary gland tumors usually occur as single lesions.
  • To have more than one tumor is unusual.
  • We report a case of an adult male who presented with a mucoepidermoid carcinoma involving the minor salivary glands of the palate at age 57 years, followed by an adenoid cystic carcinoma of the floor of mouth at age 63 years.
  • There are 31 acceptable cases of multiple malignant salivary gland neoplasms reported in the world literature.
  • Multiple malignant tumors of the same histologic type are more common than those of different histologic type.
  • Polymorphous low-grade adenocarcinoma accounted for three of the four cases of multiple malignant tumors involving minor salivary glands.
  • Individuals with a history of malignancy are at risk for the development of additional malignant tumors and should receive appropriate clinical follow-up.
  • [MeSH-major] Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / pathology. Mouth Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Palatal Neoplasms / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology

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  • (PMID = 20614341.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2807610
  • [Keywords] NOTNLM ; Metachronous neoplasms / Multiple malignant salivary gland neoplasms / Salivary gland neoplasms / Salivary gland tumors / Synchronous neoplasms
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2. Jung YH, Kang MS: Composite follicular variant of papillary carcinoma and mucoepidermoid carcinoma of thyroid gland: a case report. J Korean Med Sci; 2010 Nov;25(11):1683-7
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  • [Title] Composite follicular variant of papillary carcinoma and mucoepidermoid carcinoma of thyroid gland: a case report.
  • Pathologically, the tumor had two distinct tumor components with intermingled areas: follicular variant of papillary carcinoma and mucoepidermoid carcinoma.
  • Mucoepidermoid carcinoma composed of columnar cells, mucocytes, and squamoid cells showing solid and cystic lesion.
  • Several small cysts lined by benign ciliated columnar epithelia suggesting that this tumor had originated from solid cell nest were seen around the tumor.
  • By immunohistochemistry, columnar cells and squamoid cells in mucoepidermoid carcinoma were positive for cytokeratin but negative for thyroglobulin, TTF-1 and calcitonin.
  • Tumor cells of papillary carcinoma are positive for TTF-1, thyroglobulin but negative for CEA, calcitonin and p63.
  • [MeSH-major] Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Papillary / diagnosis. Thyroid Neoplasms / diagnosis

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  • (PMID = 21060764.001).
  • [ISSN] 1598-6357
  • [Journal-full-title] Journal of Korean medical science
  • [ISO-abbreviation] J. Korean Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1; 68238-35-7 / Keratins; 9007-12-9 / Calcitonin; 9010-34-8 / Thyroglobulin
  • [Other-IDs] NLM/ PMC2967012
  • [Keywords] NOTNLM ; Carcinoma, Mucoepidermoid / Carcinoma, Papillary / Solid Cell Nests / Thyroid Gland
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3. Khandekar MM, Kavatkar AN, Patankar SA, Bagwan IB, Puranik SC, Deshmukh SD: FNAC of salivary gland lesions with histopathological correlation. Indian J Otolaryngol Head Neck Surg; 2006 Jul;58(3):246-8

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  • To evaluate utility of FNAC in salivary gland lesions.Back ground: Salivary gland lesions form about 2-6.5% of all head and neck neoplasms in adults.
  • They are easily accessible for FNAC (Fine Needle Aspiration Cytology) and risks of fistula formation or tumour implantation are low compared surgical biopsy.
  • Also, cytology can provide a distinction between asalivary and non salivary lesion, benign and malignant lesions so also specific and non specific inflammation.
  • RESULTS: 80% of the lesions were neoplastic (61% benign, 31% malignant) and 20% were neoplastic.
  • Pleomorphic adenoma was the most frequent benign neoplasm while mucoepidermoid carcinoma was the most frequent malignant lesion.

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  • (PMID = 23120304.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3450424
  • [Keywords] NOTNLM ; FNAC / Salivary Gland / Salivary Gland Tumours
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4. Gao Y, Chen SX, Luo WJ: [Clinical study of lung mucoepidermoid tumors]. Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2008 Nov;33(11):1047-9
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  • [Title] [Clinical study of lung mucoepidermoid tumors].
  • OBJECTIVE: To investigate clinical and pathological characteristics of lung mucoepidermoid tumors and summarize methods for diagnosing and treating it.
  • METHODS: Records of a total of 2,751 consecutive patients with lung cancer were reviewed and 10 of whom with mucoepidermoid tumors were identified.
  • RESULTS: Pathological examination showed that the 10 patients had low-grade mucoepidermoid tumors.
  • One patient whose tumor was located in trachea recurred 5.2 years after the operation.
  • Lung mucoepidermoid tumors should be treated with complete surgical resection with lymph node sampling and dissection and close follow-up.
  • [MeSH-major] Carcinoma, Mucoepidermoid / drug therapy. Lung Neoplasms / diagnosis

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  • (PMID = 19060374.001).
  • [ISSN] 1672-7347
  • [Journal-full-title] Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
  • [ISO-abbreviation] Zhong Nan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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5. Chua AP, Joshi M, Mehta AC: Bronchial mucoepidermoid carcinoma. J Bronchology Interv Pulmonol; 2009 Jan;16(1):39-40

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  • [Title] Bronchial mucoepidermoid carcinoma.
  • We report a case of a minimally fluoro-2-deoxy-D-glucose avid bronchial mucoepidermoid tumor in a young male heavy smoker who presented with hemoptysis and a normal chest x-ray.

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  • (PMID = 23168467.001).
  • [ISSN] 1944-6586
  • [Journal-full-title] Journal of bronchology & interventional pulmonology
  • [ISO-abbreviation] J Bronchology Interv Pulmonol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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6. Bell D, Luna MA, Weber RS, Kaye FJ, El-Naggar AK: CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association. Genes Chromosomes Cancer; 2008 Apr;47(4):309-14
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  • [Title] CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association.
  • The t(11;19) translocation and its CRTC1/MAML2 fusion transcript have been identified in several examples of both Warthin's tumor and mucoepidermoid carcinoma and are believed to be associated with the development of a subset of these tumors.
  • To determine whether Warthin's tumor and mucoepidermoid carcinoma are genetically related, we used reverse transcriptase-polymerase chain reaction and DNA sequencing to analyze microdissected components of three tumors consisting of Warthin's tumor and mucoepidermoid carcinoma.
  • We also investigated a metastatic melanoma to Warthin's tumor and a Warthin's carcinoma of the parotid gland for comparison.
  • The fusion transcript was identified in both Warthin's tumor and matching mucoepidermoid carcinoma components of all three tumors, in the Warthin's carcinoma, and in the Warthin's tumor component but not in the metastatic melanoma.
  • The results provide evidence for a link between the t(11;19) fusion gene and the development of a subset of Warthin's tumors with concurrent mucoepidermoid carcinoma and possible malignant transformation to Warthin's carcinoma.
  • [MeSH-major] Adenolymphoma / genetics. Carcinoma, Mucoepidermoid / genetics. DNA-Binding Proteins / genetics. Nuclear Proteins / genetics. Oncogene Proteins, Fusion / genetics. Parotid Neoplasms / genetics. Transcription Factors / genetics
  • [MeSH-minor] Adult. Aged. Female. Humans. Male. Melanoma / genetics. Melanoma / secondary. Middle Aged. RNA, Messenger. Reverse Transcriptase Polymerase Chain Reaction. Thyroid Neoplasms / genetics

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  • [Copyright] (c) 2008 Wiley-Liss, Inc.
  • (PMID = 18181164.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA-16672
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / RNA, Messenger; 0 / Transcription Factors
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7. Gilbert J, Li Y, Pinto HA, Jennings T, Kies MS, Silverman P, Forastiere AA: Phase II trial of taxol in salivary gland malignancies (E1394): a trial of the Eastern Cooperative Oncology Group. Head Neck; 2006 Mar;28(3):197-204
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  • BACKGROUND: Malignant tumors of the salivary glands make up approximately 5% of head and neck cancers.
  • METHODS: Chemo-naive patients with histologically confirmed recurrent or metastatic carcinoma of salivary gland origin (mucoepidermoid, adenocarcinoma, or adenoid cystic) were eligible.
  • Eight partial responses were seen among the 31 patients with mucoepidermoid or adenocarcinoma histologic findings for a response rate of 26%.
  • CONCLUSION: Paclitaxel demonstrates moderate activity in salivary gland tumors of mucoepidermoid and adenocarcinoma histology.
  • [MeSH-major] Antineoplastic Agents, Phytogenic / therapeutic use. Paclitaxel / therapeutic use. Salivary Gland Neoplasms / drug therapy
  • [MeSH-minor] Adenocarcinoma / drug therapy. Adenocarcinoma / mortality. Adult. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / drug therapy. Carcinoma, Adenoid Cystic / mortality. Carcinoma, Mucoepidermoid / drug therapy. Carcinoma, Mucoepidermoid / mortality. Female. Follow-Up Studies. Humans. Infusions, Intravenous. Male. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / mortality

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  • [Copyright] (c) 2005 Wiley Periodicals, Inc.
  • (PMID = 16470745.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / CA14548; United States / NCI NIH HHS / CA / CA16116; United States / NCI NIH HHS / CA / CA17145; United States / NCI NIH HHS / CA / CA21115; United States / NCI NIH HHS / CA / CA23318; United States / NCI NIH HHS / CA / CA66636
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel
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8. Friedrich RE, Klapdor R, Bartel-Friedrich S: Rapidly progressive and metastatic mucoepidermoid carcinoma: application of serological tumor markers. Anticancer Res; 2007 Jul-Aug;27(4A):2099-100
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  • [Title] Rapidly progressive and metastatic mucoepidermoid carcinoma: application of serological tumor markers.
  • Mucoepidermoid carcinoma (MEC) of the salivary gland is a rare entity.
  • A distinction of 2 variants has been proposed: the low-grade tumor with a favourable prognosis and the high-grade tumor with a poor prognosis.
  • This excellent prognosis might contribute to the unacceptable retention of the term "mucoepidermoid tumor" in the medical terminology, even in current medical textbooks.
  • We describe the rapid fatal outcome of a patient with MEC in order to emphasize the malignant characteristics of this tumor and the possible application of tumor markers for the diagnosis of metastasizing MEC.
  • [MeSH-major] Biomarkers, Tumor / blood. Carcinoma, Mucoepidermoid / blood. Salivary Gland Neoplasms / blood
  • [MeSH-minor] Bone Neoplasms / secondary. Disease Progression. Fatal Outcome. Humans. Liver Neoplasms / secondary. Lung Neoplasms / secondary. Male. Middle Aged. Salivary Glands, Minor / pathology

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  • (PMID = 17649828.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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9. Gbotolorun OM, Arotiba GT, Effiom OA, Omitola OG: Minor salivary gland tumours in a Nigerian hospital: a retrospective review of 146 cases. Odontostomatol Trop; 2008 Sep;31(123):17-23
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  • The majority (62.3%) of these tumours was malignant, and the most common malignant tumour was mucoepidermoid carcinoma (19.2%).
  • However, pleomorphic adenoma (34.2%) was the most common tumour overall.
  • Both benign (67.2%) and malignant (23.9%) tumors were most frequently located in the palate.
  • Both sexes were equally affected (Male-female ratio 1 to 1), but a higher proportion of benign tumours were found in the palate of females (75%) than their male counterparts (64%).
  • CONCLUSION: These findings show that majority of these tumours were malignant (62.3%), though pleomorphic adenoma was the most common tumour.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Salivary Gland Neoplasms / pathology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adolescent. Adult. Age Distribution. Age Factors. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / pathology. Child. Child, Preschool. Female. Humans. Male. Middle Aged. Nigeria. Palatal Neoplasms / pathology. Retrospective Studies. Sex Distribution. Young Adult

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  • (PMID = 19266846.001).
  • [ISSN] 0251-172X
  • [Journal-full-title] Odonto-stomatologie tropicale = Tropical dental journal
  • [ISO-abbreviation] Odontostomatol Trop
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Senegal
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10. Rapidis AD, Givalos N, Gakiopoulou H, Stavrianos SD, Faratzis G, Lagogiannis GA, Katsilieris I, Patsouris E: Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients. Oral Oncol; 2007 Feb;43(2):130-6
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  • [Title] Mucoepidermoid carcinoma of the salivary glands. Review of the literature and clinicopathological analysis of 18 patients.
  • Salivary gland carcinomas are a rare and clinically diverse group of neoplasms among which mucoepidermoid carcinomas (MEC) are reported to be the most frequently encountered.
  • Histologically, 50% of tumors were classified as low grade, 28% as intermediate and 22% as high-grade MECs.
  • Positive surgical margins were documented in six cases (33%) and all in tumors of high or intermediate histological grade.
  • The 5-year overall disease specific survival rate was 85%.
  • Statistical multivariate analysis demonstrated that the factor that significantly correlated with overall survival was the histological grade of tumors (Log Rank test: p=0.013).
  • [MeSH-major] Carcinoma, Mucoepidermoid / surgery. Salivary Gland Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Radiotherapy, Adjuvant. Retrospective Studies. Survival Analysis. Treatment Outcome

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  • (PMID = 16857410.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 37
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11. Musani MA, Sohail Z, Zafar S, Malik S: Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak; 2008 May;18(5):274-7

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  • All patients were surgically managed and their tumour specimen was sent for histopathology.
  • Classification of individual tumour was based on 1991 World Health Organization Classification.
  • RESULTS: Out of 204 cases, 152 (74.5%) were benign and 52 (25.5%) were malignant.
  • Benign tumours were more common in females whereas malignant tumours were common in males.
  • The mean age of patients was 34 years and 42 years for benign and malignant tumours respectively.
  • Pleomorphic adenoma was most common benign tumor (83.5%), followed by Warthins tumour.
  • The most common malignant tumour was mucoepidermoid carcinoma (60%), followed by adenoid cystic carcinoma.
  • Superficial lobe of parotid gland was the commonest site, 120 benign and all 52 malignant tumours arising from it while 32 benign tumours originated from deep lobe.
  • Parotid swelling for years was main feature of benign tumours, whereas malignant tumours presented with pain, fixation to skin or underlying structure, cervical lymphadenopathy and facial palsy.
  • CONCLUSION: Pleomorphic adenoma was the most common benign tumour and mucoepidermoid carcinoma was most common malignant tumour.
  • [MeSH-major] Parotid Neoplasms / diagnosis
  • [MeSH-minor] Adolescent. Adult. Aged. Biopsy, Fine-Needle. Child. Diagnosis, Differential. Disease Progression. Female. Humans. Magnetic Resonance Imaging. Male. Middle Aged. Morbidity / trends. Neoplasm Staging / methods. Pakistan / epidemiology. Retrospective Studies. Severity of Illness Index. Tomography, X-Ray Computed

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  • (PMID = 18541080.001).
  • [ISSN] 1022-386X
  • [Journal-full-title] Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
  • [ISO-abbreviation] J Coll Physicians Surg Pak
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Multicenter Study
  • [Publication-country] Pakistan
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12. Crain N, Nelson BL, Barnes EL, Thompson LD: Ceruminous gland carcinomas: a clinicopathologic and immunophenotypic study of 17 cases. Head Neck Pathol; 2009 Mar;3(1):1-17

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ceruminal gland carcinomas are rare neoplasms confined to the skin lining the cartilaginous part of the external auditory canal.
  • Histologically, the tumors demonstrated a solid to cystic pattern, composed of an infiltrating glandular to cribriform arrangement of epithelial cells.
  • Histologic features included a dual cell population (although not the dominant histology), increased cellularity, moderate to severe nuclear pleomorphism, irregular nucleoli, increased mitotic figures (mean, 3/10 HPF), including atypical forms, and tumor necrosis (n = 2).
  • Tumors were divided into three types of adenocarcinoma based on pattern of growth and cell type (ceruminous, NOS [n = 12], adenoid cystic [n = 4], mucoepidermoid [n = 1]).
  • Metastatic adenocarcinoma or direct extension from salivary gland neoplasms are the principle differential considerations.
  • Eleven patients were alive or had died of unrelated causes without evidence of disease (mean, 11.2 years); six patients had died with disease (mean, 4.9 years), all of whom had developed local recurrence.
  • CONCLUSION: Ceruminous-type carcinomas, with the exception of ceruminous mucoepidermoid carcinoma, all demonstrated a dual cell population of basal myoepithelial-type cells and luminal apocrine cells.
  • [MeSH-major] Carcinoma / pathology. Ear Neoplasms / pathology. Ear, External / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Disease-Free Survival. Female. Humans. Immunohistochemistry. Male. Middle Aged. Otorhinolaryngologic Surgical Procedures. Radiotherapy. Retrospective Studies

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  • (PMID = 20596983.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2807538
  • [Keywords] NOTNLM ; Adenoid cystic / Carcinoma / Ceruminal / Ceruminous / Ear / Gland / Immunohistochemistry / Mucoepidermoid / Prognosis
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13. Lin CC, Tsai MH, Huang CC, Hua CH, Tseng HC, Huang ST: Parotid tumors: a 10-year experience. Am J Otolaryngol; 2008 Mar-Apr;29(2):94-100

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid tumors: a 10-year experience.
  • PURPOSE: The aim of the present study was to analyze the clinical presentation, histopathology, and complications of parotid tumors, as well as the management of malignant parotid tumors.
  • Data including age, sex, clinical signs and symptoms, histologic findings, complications, malignant tumor stage, and prognosis were collected from medical charts.
  • RESULTS: Of the 271 patients who underwent parotidectomy, 229 (85%) had benign tumors, 33 (12%) had malignant tumors, and 9 had chronic inflammatory disease (3%).
  • The most common benign tumor was pleomorphic adenoma (51%), and the most common malignant tumor was mucoepidermoid carcinoma (3%).
  • The 5-year overall survival rate was 42%, and the disease-specific survival rate for malignant tumor was 72%.
  • Only disease stage was the statistically significant prognostic factor of malignancy.
  • CONCLUSIONS: Standardized superficial and total parotidectomy are safe procedures for treating parotid tumors.
  • Management of malignant tumors depends on tumor stage and histologic grade.
  • Advanced tumor stage is a predictor of poor outcome.
  • [MeSH-major] Parotid Neoplasms / pathology. Parotid Neoplasms / therapy
  • [MeSH-minor] Adenolymphoma / mortality. Adenolymphoma / pathology. Adenolymphoma / therapy. Adenoma, Oxyphilic / mortality. Adenoma, Oxyphilic / pathology. Adenoma, Oxyphilic / therapy. Adenoma, Pleomorphic / mortality. Adenoma, Pleomorphic / pathology. Adenoma, Pleomorphic / therapy. Adolescent. Adult. Aged. Aged, 80 and over. Carcinoma / mortality. Carcinoma / pathology. Carcinoma / therapy. Child. Facial Paralysis / etiology. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neck Dissection. Neoplasm Recurrence, Local. Neoplasm Staging. Postoperative Complications. Prognosis. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies

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  • (PMID = 18314019.001).
  • [ISSN] 0196-0709
  • [Journal-full-title] American journal of otolaryngology
  • [ISO-abbreviation] Am J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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14. While B, Whiteside OJ, Desai V, Gurr P: Sebaceous lymphadenoma: a case report and review of the literature. Ear Nose Throat J; 2010 Aug;89(8):E22-3
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Sebaceous lymphadenomas of the salivary glands are rare, benign tumors that are effectively treated by complete excision.
  • The challenge that these tumors present lies in their accurate diagnosis.
  • Because of their histologic similarity to related malignant tumors, such as mucoepidermoid carcinomas and sebaceous lymphadenocarcinomas, misdiagnosis could lead to unnecessarily radical treatment.
  • We highlight the need for careful clinical and histologic diagnosis in tumors of the salivary glands.
  • [MeSH-major] Adenolymphoma / diagnosis. Magnetic Resonance Imaging. Parotid Neoplasms / diagnosis

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  • (PMID = 20737364.001).
  • [ISSN] 1942-7522
  • [Journal-full-title] Ear, nose, & throat journal
  • [ISO-abbreviation] Ear Nose Throat J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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15. Carlson DL: Necrotizing sialometaplasia: a practical approach to the diagnosis. Arch Pathol Lab Med; 2009 May;133(5):692-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: Necrotizing sialometaplasia is a benign, self-limited lesion of both major and minor salivary glands, although more commonly the latter.
  • It can represent a diagnostic dilemma and may be mistaken for a malignant neoplasm, such as mucoepidermoid carcinoma, as well as invasive squamous cell carcinoma.
  • [MeSH-minor] Adult. Biomarkers / metabolism. Bulimia / complications. Bulimia / diagnosis. Calcium-Binding Proteins / metabolism. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Humans. Male. Membrane Proteins / metabolism. Microfilament Proteins / metabolism. Salivary Gland Neoplasms / diagnosis

  • The Weizmann Institute of Science GeneCards and MalaCards databases. gene/protein/disease-specific - MalaCards for necrotizing sialometaplasia .
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  • [CommentIn] Arch Pathol Lab Med. 2010 Jan;134(1):17 [20073597.001]
  • (PMID = 19415943.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CKAP4 protein, human; 0 / Calcium-Binding Proteins; 0 / Membrane Proteins; 0 / Microfilament Proteins; 0 / calponin
  • [Number-of-references] 25
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16. Lee EY, Vargas SO, Sawicki GS, Boyer D, Grant FD, Voss SD: Mucoepidermoid carcinoma of bronchus in a pediatric patient: (18)F-FDG PET findings. Pediatr Radiol; 2007 Dec;37(12):1278-82
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid carcinoma of bronchus in a pediatric patient: (18)F-FDG PET findings.
  • In children, primary neoplasms of the tracheobronchial tree and lungs are rare; most are malignant.
  • Of the primary malignant pulmonary neoplasms arising in childhood, mucoepidermoid carcinoma accounts for approximately 10%.
  • Due to its well-confined local growth within the airway, mucoepidermoid carcinoma commonly produces respiratory symptoms from progressive tracheal or bronchial obstruction.
  • Mucoepidermoid tumor has minimal metastatic potential in children, and local resection alone is the current treatment of choice.
  • Early detection, diagnosis, and surgical resection of mucoepidermoid tumor are especially important in pediatric patients since the bulk of the remaining pulmonary parenchyma can be preserved, thereby decreasing the thoracic deformity and pulmonary functional morbidity.
  • Radiographic and CT imaging findings of bronchial mucoepidermoid carcinoma in children have been described in several case reports.
  • However, to the best of our knowledge, imaging findings of 2-((18)F)-fluoro-2-deoxy-D: -glucose positron emission tomography ((18)F-FDG PET) of mucoepidermoid carcinoma of the bronchus in pediatric patients have not been well established.
  • We report a mucoepidermoid carcinoma arising from the right upper lobe bronchus in a 15-year-old girl with an emphasis on the (18)F-FDG PET findings.
  • [MeSH-major] Bronchial Neoplasms / diagnostic imaging. Carcinoma, Mucoepidermoid / diagnostic imaging. Tomography, Emission-Computed

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  • (PMID = 17922270.001).
  • [ISSN] 0301-0449
  • [Journal-full-title] Pediatric radiology
  • [ISO-abbreviation] Pediatr Radiol
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 5 K08 CA 093554
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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17. Neville HL, Hogan AR, Zhuge Y, Perez EA, Cheung MC, Koniaris LG, Thompson WR, Sola JE: Incidence and outcomes of malignant pediatric lung neoplasms. J Surg Res; 2009 Oct;156(2):224-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Incidence and outcomes of malignant pediatric lung neoplasms.
  • BACKGROUND: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors.
  • METHODS: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age.
  • Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%).
  • The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%).
  • Endocrine and mucoepidermoid tumors had the best survival.
  • Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death.
  • Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis.
  • [MeSH-major] Lung Neoplasms / epidemiology. SEER Program

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  • (PMID = 19631347.001).
  • [ISSN] 1095-8673
  • [Journal-full-title] The Journal of surgical research
  • [ISO-abbreviation] J. Surg. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Dhanuthai K, Boonadulyarat M, Jaengjongdee T, Jiruedee K: A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais. J Oral Pathol Med; 2009 Jul;38(6):495-500
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A clinico-pathologic study of 311 intra-oral salivary gland tumors in Thais.
  • BACKGROUND: There have been several epidemiologic studies on intra-oral salivary gland tumors in several countries, but little is known of these tumors in Thailand.
  • OBJECTIVES: To determine the relative frequency and distribution of various types of intra-oral salivary gland tumors in the Thai population.
  • METHODS: The files of the Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, from 1969 to 2007 were searched for intra-oral salivary gland tumors.
  • Histopathologic slides were reviewed and reclassified according to the 2005 WHO Classification of Head and Neck Tumors.
  • The age, gender, race, and anatomical distribution of the tumors were collected from the patients' records.
  • RESULTS: Of the 16,358 accessioned cases, 311 cases (1.90%) were diagnosed as intra-oral salivary gland tumors.
  • One hundred and forty-seven cases (47.27%) were benign tumors, while 164 cases (52.73%) were malignant tumors.
  • Pleomorphic adenoma was the most common intra-oral salivary gland tumor.
  • CONCLUSIONS: Pleomorphic adenoma is the most common intra-oral salivary gland tumor and the most common benign intra-oral salivary gland tumor, while mucoepidermoid carcinoma is the most common malignant intra-oral salivary gland tumor.
  • Intra-oral salivary gland tumors in Thailand elicit similar trend as in previous studies, with only minor differences such as the ranking of some tumors, the higher incidence of intra-bony location, and the lower incidence of polymorphous low-grade adenocarcinoma.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Mucoepidermoid / epidemiology. Child. Female. Humans. Incidence. Male. Middle Aged. Palatal Neoplasms / epidemiology. Retrospective Studies. Sex Factors. Thailand / epidemiology. Young Adult

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  • (PMID = 19594840.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
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19. Laikui L, Hongwei L, Hongbing J, Zhixiu H: Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases. J Oral Pathol Med; 2008 Apr;37(4):201-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial salivary gland tumors of children and adolescents in west China population: a clinicopathologic study of 79 cases.
  • OBJECTIVE: Determine the clinical and histopathologic features of epithelial salivary gland tumors of children and adolescents.
  • METHODS: A total of 79 cases of epithelial salivary gland tumors of children and adolescents were retrieved from the files.
  • RESULTS: Sixty tumors (75.9%) were benign and 19 (24.1%) malignant.
  • The most common tumor overall was pleomorphic adenoma (PA).
  • PA was the most common type of benign tumor.
  • The most common malignant tumor was mucoepidermoid carcinoma.
  • One patient with mucoepidermoid carcinoma showed local recurrences and died from the tumor 3 years after the initial treatment.
  • CONCLUSIONS: Our data showed that the salivary gland tumors in children and adolescents may be the higher incidence of benign tumors, especially of PA; the slightly higher tendency for female predominance; the higher incidence of parotid glands.
  • Mucoepidermoid carcinoma was the most common malignant tumor, with majority of low grade.
  • Initial treatment should be planned to excise the tumor completely with satisfactory margins.
  • [MeSH-major] Adenoma, Pleomorphic / pathology. Carcinoma, Mucoepidermoid / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 18205745.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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20. Drivas EI, Skoulakis CE, Symvoulakis EK, Bizaki AG, Lachanas VA, Bizakis JG: Pattern of parotid gland tumors on Crete, Greece: a retrospective study of 131 cases. Med Sci Monit; 2007 Mar;13(3):CR136-40

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Pattern of parotid gland tumors on Crete, Greece: a retrospective study of 131 cases.
  • BACKGROUND: Salivary gland tumors constitute a highly heterogeneous group.
  • There are few large epidemiological studies of benign and malignant salivary gland tumors in Greece.
  • The aim of the present study was to define the pattern of parotid gland neoplasms on the island of Crete.
  • Gender and age of the patients, size, location, and histology of the tumors, as well as postoperative complications were analyzed and tabulated.
  • RESULTS: There were 101 (77.1%) benign parotid gland tumors and 30 (22.9%) of malignant ones.
  • The most common benign tumor was pleomorphic adenoma (44.2%), while the most common malignant tumor was mucoepidermoid carcinoma (5.3%).
  • Median age was 48.2 years (range: 16-75 years) in patients with benign tumors and 65.4 years (range: 27-90 years) in patients with malignancy.
  • CONCLUSIONS: On Crete, parotid gland tumors show epidemiological characteristics similar to studies worldwide.
  • Benign parotid tumors are largely more frequent than malignant tumors.
  • The most common benign parotid gland tumor was pleomorphic adenoma, while the most frequent malignant tumor was mucoepidermoid carcinoma.
  • Future research needs to be done to better define the epidemiology of these tumors among the Greek population.
  • [MeSH-major] Parotid Neoplasms / pathology

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  • (PMID = 17325637.001).
  • [ISSN] 1234-1010
  • [Journal-full-title] Medical science monitor : international medical journal of experimental and clinical research
  • [ISO-abbreviation] Med. Sci. Monit.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
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21. Khadilkar UN, Kumar S, Prabhu PP, Kamath M: Mucoepidermoid carcinoma of lung: a case report. Indian J Pathol Microbiol; 2007 Jul;50(3):560-2
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  • [Title] Mucoepidermoid carcinoma of lung: a case report.
  • Mucoepidermoid lung tumours are uncommon neoplasms comprising of 0.2% of all the lung tumours and historically included under the term bronchial adenomas.
  • This is a case report of a bronchial tumour in the hilar region present since 3 years.
  • The neoplasm could be easily classified as a mucoepidermoid tumour of low malignant potential, as it resembled the histologically identical lesion in the main salivary glands.
  • The case is reported for its rarity and for the histological evaluation of the malignant potential in an apparently clinically benign neoplasm.
  • [MeSH-major] Carcinoma, Mucoepidermoid / diagnosis. Lung Neoplasms / diagnosis

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  • (PMID = 17883135.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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22. Gaissert HA, Grillo HC, Shadmehr MB, Wright CD, Gokhale M, Wain JC, Mathisen DJ: Uncommon primary tracheal tumors. Ann Thorac Surg; 2006 Jul;82(1):268-72; discussion 272-3
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  • [Title] Uncommon primary tracheal tumors.
  • BACKGROUND: Primary tracheal tumors other than adenoid cystic or squamous cell carcinoma are uncommon and have a heterogeneous histologic appearance.
  • METHODS: A retrospective analysis was performed of uncommon tracheal tumors among 360 primary tracheal tumors seen over 40 years, excluding adenoid cystic and squamous cell carcinoma.
  • RESULTS: Of 90 patients, 34 (38%) had benign tumors and 56 malignant: 11 carcinoid tumors, 14 mucoepidermoid carcinomas, 13 sarcomas, 15 nonsquamous bronchogenic carcinomas, 2 lymphomas, and 1 melanoma.
  • Dyspnea was the most common symptom in benign tumors and hemoptysis in malignant tumors.
  • After resection, survival at 10 years was 94% for benign and 83% for carcinoid tumors, and at 5 years survival was 60% for bronchogenic carcinoma, 100% for mucoepidermoid tumors, and 78% for sarcomas.
  • CONCLUSIONS: Surgical resection of uncommon primary tracheal tumors alleviates airway obstruction, is curative in patients with benign or slow-growing malignant lesions, and prolongs survival in highly malignant lesions.
  • [MeSH-major] Tracheal Neoplasms / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Bronchi / surgery. Bronchoscopy. Child. Child, Preschool. Combined Modality Therapy. Female. Follow-Up Studies. Hospital Mortality. Humans. Laryngeal Neoplasms / epidemiology. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / surgery. Laryngectomy. Life Tables. Male. Middle Aged. Neoplasm Metastasis. Neoplasm Recurrence, Local / epidemiology. Postoperative Complications / epidemiology. Radiotherapy, Adjuvant. Reoperation. Retrospective Studies. Survival Analysis

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  • (PMID = 16798228.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
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23. Luna MA: Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol; 2006 Nov;13(6):293-307
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  • [Title] Salivary mucoepidermoid carcinoma: revisited.
  • Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm composed of varying proportions of mucous, epidermoid, intermediate, columnar, and clear cells and often demonstrates prominent cystic growth.
  • Because even low-grade neoplasms may metastasize, the term mucoepidermoid tumor is inappropriate.
  • The 3-level grading approach to tumor classification has found general acceptance among pathologists; differences in biologic behavior can be demonstrated even though clinical stage has become a better prognosticator.
  • We describe these new schemes, the histologic variants of MEC, and the ancillary methods that allow for further stratification of patients with MEC, especially for patients with grade 2 tumors, which have a variable and unpredictable clinical course.
  • [MeSH-major] Carcinoma, Mucoepidermoid / pathology. Salivary Gland Neoplasms / pathology

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  • (PMID = 17075295.001).
  • [ISSN] 1072-4109
  • [Journal-full-title] Advances in anatomic pathology
  • [ISO-abbreviation] Adv Anat Pathol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 65
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24. Hunt JL: Unusual thyroid tumors: a review of pathologic and molecular diagnosis. Expert Rev Mol Diagn; 2005 Sep;5(5):725-34
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  • [Title] Unusual thyroid tumors: a review of pathologic and molecular diagnosis.
  • The most common thyroid neoplasms are either follicular derived (papillary, follicular and Hürthle cell lesions) or C-cell derived (medullary carcinoma).
  • The diagnosis of these tumors can usually be made at the histologic level, with immunohistochemical stains necessary in some circumstances.
  • Specific molecular mutations have been described that can be diagnostically useful or explain, in part, their pathogenesis, including the well-known Ret/PTC and PPARgamma-PAX8 translocations, point mutations in the Ret, Ras and BRAF genes, and loss of heterozygosity of multiple different tumor suppressor genes.
  • Some unusual tumors of the thyroid gland are more difficult to diagnose.
  • In examining these lesions, the pathologist may use the hematoxylin and eosin-stained morphology, coupled with an analysis of the immunohistochemical staining profiles and possibly analysis of the underlying molecular mutational patterns.
  • These less common thyroid tumors include tall cell and cribriform-morular variants of papillary carcinoma, hyalinizing trabecular tumor, mucoepidermoid and sclerosing mucoepidermoid carcinoma with eosinophilia, poorly differentiated (insular) carcinoma, and undifferentiated (anaplastic) carcinoma.
  • The diagnostic features of these rare tumors, including the histology, immunohistochemical expression profiles and the known molecular mutational profiles of each, are reviewed.
  • [MeSH-major] Molecular Diagnostic Techniques. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / metabolism

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  • (PMID = 16149875.001).
  • [ISSN] 1744-8352
  • [Journal-full-title] Expert review of molecular diagnostics
  • [ISO-abbreviation] Expert Rev. Mol. Diagn.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 116
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25. Shet T, Ghodke R, Kane S, Chinoy RN: Cytomorphologic patterns in papillary cystic variant of acinic cell carcinoma of the salivary gland. Acta Cytol; 2006 Jul-Aug;50(4):388-92
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  • However, common to all was a papillary pattern and a cystic fluid background with or without mucin blobs; that led to misdiagnosing the tumor as mucoepidermoid carcinoma on 2 occasions.
  • The tumor did not show any acinar pattern and lacked naked nuclei in the background.

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  • (PMID = 16901000.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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26. Fauroux B, Aynie V, Larroquet M, Boccon-Gibod L, Ducou le Pointe H, Tamalet A, Clément A: Carcinoid and mucoepidermoid bronchial tumours in children. Eur J Pediatr; 2005 Dec;164(12):748-52
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  • [Title] Carcinoid and mucoepidermoid bronchial tumours in children.
  • The aim of the study was to determine the characteristic features and outcome of carcinoid or mucoepidermoid tumours in children.
  • A retrospective analysis of all patients treated for a carcinoid or mucoepidermoid tumour in France between 1984 and 2001 was performed.
  • There were 11 cases of carcinoid tumour and 6 cases of mucoepidermoid tumour.
  • Fibre optic bronchoscopy confirmed the presence of a bronchial tumour in all cases and endobronchial biopsies were diagnostic in 11 of 12 cases.
  • A chest CT scan revealed the presence of a hypervascular tumour in 8 of 12 patients.
  • The distribution of the location of the tumours was equal between the right and the left lung, and, in 9 cases, the airways were totally occluded by the tumour.
  • In 2 patients, auscultation assymetry and an episode of haemoptysis revealed the recurrence of a mucoepidermoid tumour, successfully cured by removal of the tumour and chemotherapy and radiotherapy in one child.
  • CONCLUSION: Pulmonary carcinoid and mucoepidermoid tumours are rare in children.
  • [MeSH-major] Bronchial Neoplasms. Carcinoid Tumor. Carcinoma, Mucoepidermoid

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  • (PMID = 16133240.001).
  • [ISSN] 0340-6199
  • [Journal-full-title] European journal of pediatrics
  • [ISO-abbreviation] Eur. J. Pediatr.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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27. Sánchez-Mora N, Parra-Blanco V, Cebollero-Presmanes M, Carretero-Albiñana L, Herranz ML, Alvarez-Fernández E: Mucoepidermoid tumors of the bronchus. Ultrastructural and immunohistochemical study. Histiogenic correlations. Histol Histopathol; 2007 01;22(1):9-13

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mucoepidermoid tumors of the bronchus. Ultrastructural and immunohistochemical study. Histiogenic correlations.
  • Bronchial mucoepidermoid tumors are uncommon neoplasms, morphologically similar to their salivary gland counterpart.
  • The aim of this study is to identify myoepithelial cells and speculate on their role in the origin of these tumors.
  • METHODS AND RESULTS: Sixteen bronchial mucoepidermoid tumor surgical specimens were formalin-fixed, paraffin-embedded and studied using a panel of nine antibodies in order to identify a myoepithelial differentiation.
  • The different types of cells of the primary bronchial mucoepidermoid tumor (mucous luminal, intermediate and squamous) reacted strongly against AE1, CK7, 34bE12 and weakly with AE3, CK18 and CK8/18/19.
  • CONCLUSION: The immunohistochemical and the ultrastructural study of bronchial mucoepidermiod tumors support a ductal unit origin, without a myoepithelial participation.
  • [MeSH-major] Bronchi / pathology. Bronchi / ultrastructure. Bronchial Neoplasms / pathology. Bronchial Neoplasms / ultrastructure. Gene Expression Regulation, Neoplastic. Mucoepidermoid Tumor / pathology. Mucoepidermoid Tumor / ultrastructure
  • [MeSH-minor] Adult. Aged. Antigens, Neoplasm / biosynthesis. Biopsy. Female. Humans. Immunohistochemistry. Male. Microscopy, Electron. Middle Aged

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  • (PMID = 17128406.001).
  • [ISSN] 1699-5848
  • [Journal-full-title] Histology and histopathology
  • [ISO-abbreviation] Histol. Histopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antigens, Neoplasm
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28. Ito FA, Ito K, Coletta RD, Vargas PA, Lopes MA: Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors. Braz Oral Res; 2009 Oct-Dec;23(4):393-8
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  • [Title] Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors.
  • The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands.
  • A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed.
  • Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma.
  • In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas.
  • However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.
  • [MeSH-major] Adenocarcinoma / pathology. Neoplasms, Complex and Mixed / pathology. Receptors, Androgen / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Salivary Gland Neoplasms / pathology

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  • (PMID = 20027446.001).
  • [ISSN] 1807-3107
  • [Journal-full-title] Brazilian oral research
  • [ISO-abbreviation] Braz Oral Res
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Brazil
  • [Chemical-registry-number] 0 / Receptors, Androgen; 0 / Receptors, Estrogen; 0 / Receptors, Progesterone
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29. Anzick SL, Chen WD, Park Y, Meltzer P, Bell D, El-Naggar AK, Kaye FJ: Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions. Genes Chromosomes Cancer; 2010 Jan;49(1):59-69
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  • [Title] Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions.
  • The CRTC1-MAML2 fusion oncogene underlies the etiology of mucoepidermoid salivary gland carcinoma (MEC) where it confers a favorable survival outcome as compared with fusion-negative MEC.
  • While these analyses suggested that detection of CRTC1-MAML2 serves as a useful prognostic biomarker, we recently identified outlier cases of fusion-positive MEC associated with advanced-staged lethal disease.
  • To identify additional genetic alterations that might cooperate with CRTC1-MAML2 to promote disease progression, we performed a pilot high-resolution oligonucleotide array CGH (aCGH) and PCR-based genotyping study on 23 MEC samples including 14 fusion-positive samples for which we had clinical outcome information.
  • We did not detect either activating EGFR mutations, nor copy number gains at the EGFR or ERBB2 loci as poor prognostic features for fusion-positive MEC in any of the tumor specimens.
  • Prospective studies with larger case series will be needed to confirm that combined CRTC1-MAML2 and CDKN2A genotyping will optimally stage this disease.
  • [MeSH-major] Carcinoma, Mucoepidermoid / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA-Binding Proteins / genetics. Gene Deletion. Nuclear Proteins / genetics. Oncogene Proteins, Fusion. Transcription Factors / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Comparative Genomic Hybridization. Disease Progression. Female. Gene Expression Regulation, Neoplastic. Genotype. Humans. Male. Middle Aged. Pilot Projects. Polymerase Chain Reaction. Prognosis. Receptor, Epidermal Growth Factor. Receptor, ErbB-2. Salivary Gland Neoplasms / genetics. Salivary Gland Neoplasms / pathology

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  • (PMID = 19827123.001).
  • [ISSN] 1098-2264
  • [Journal-full-title] Genes, chromosomes & cancer
  • [ISO-abbreviation] Genes Chromosomes Cancer
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 SC007256-19
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CRTC1 protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / MAML2 protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Transcription Factors; EC 2.7.10.1 / EGFR protein, human; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ NIHMS143697; NLM/ PMC2783528
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30. Whatley WS, Thompson JW, Rao B: Salivary gland tumors in survivors of childhood cancer. Otolaryngol Head Neck Surg; 2006 Mar;134(3):385-8
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  • [Title] Salivary gland tumors in survivors of childhood cancer.
  • BACKGROUND: There is an increased incidence of second malignant neoplasms in survivors of childhood cancers.
  • The most common second malignancies are acute leukemia, bone and soft tissue tumors, and carcinoma of the skin, breast, and thyroid.
  • Although, ionizing radiation has been demonstrated to increase the risk of developing a salivary gland neoplasm, there are few reports of salivary gland neoplasms occurring in patients treated for cancer in childhood.
  • RESULTS: Twelve survivors of childhood cancer developed a salivary gland neoplasm after completion of treatment.
  • The pathology of the salivary gland tumors were mucoepidermoid carcinoma (10), adenoid cystic carcinoma (1) , and pleomorphic adenoma (1).
  • All patients were treated with surgical excision of the primary tumor, and postoperative radiation was added in select patients.
  • Eleven patients were alive with no evidence of disease at last follow-up, and 1 patient was alive with clinical evidence of pulmonary metastasis.
  • CONCLUSION: Radiation and chemotherapy used to treat patients with childhood malignancies increases the risk of developing a second neoplasm of salivary gland origin.
  • The majority of these neoplasms are malignant; mucoepidermoid carcinoma occurs most frequently.
  • The treatment of these tumors includes surgical excision of the primary, with neck dissection in patients with clinical evidence of nodal metastasis, and postoperative radiation added for pathologies with adverse features.
  • [MeSH-major] Neoplasms, Second Primary / diagnosis. Salivary Gland Neoplasms / diagnosis. Survivors
  • [MeSH-minor] Adenoma, Pleomorphic / diagnosis. Adenoma, Pleomorphic / surgery. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / surgery. Carcinoma, Mucoepidermoid / diagnosis. Carcinoma, Mucoepidermoid / surgery. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis / diagnosis. Male. Neck Dissection. Neoplasms / drug therapy. Neoplasms / radiotherapy. Radiotherapy, Adjuvant. Registries. Retrospective Studies. Risk Factors


31. Atarbashi Moghadam S, Atarbashi Moghadam F, Dadfar M: Epithelial salivary gland tumors in ahvaz, southwest of iran. J Dent Res Dent Clin Dent Prospects; 2010;4(4):120-3

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epithelial salivary gland tumors in ahvaz, southwest of iran.
  • BACKGROUND AND AIMS: Salivary gland tumors are rare and specific lesions.
  • There are differences in the incidence and frequency of salivary tumors in both minor and major salivary glands in different countries.
  • This study was carried out to determine the prevalence of major and minor salivary gland tumors in Ahvaz in the south of Iran.
  • RESULTS: Of 112 cases, 84 cases were benign and 28 cases were malignant.
  • The incidence of malignant salivary gland tumors increased with age and male predominance was found in malignant tumors.
  • The majority of the tumors occurred in parotid gland.
  • Mucoepidermoid carcinoma and adenoid cystic carcinoma were the most common malignant tumors.
  • CONCLUSION: It was shown that the peak incidence age of all salivary gland tumors was the third to fifth decades, and malignant tumors mostly occurred in the sixth to eighth decades.
  • Female predominance for all the tumors and slight male predominance in malignant tumors were observed.
  • Pleomorphic adenoma was the most common benign tumor.
  • The most common malignant tumors were mucoepidermoid carcinoma and adenoid cystic carcinoma.

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  • (PMID = 23346338.001).
  • [ISSN] 2008-210X
  • [Journal-full-title] Journal of dental research, dental clinics, dental prospects
  • [ISO-abbreviation] J Dent Res Dent Clin Dent Prospects
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Iran
  • [Other-IDs] NLM/ PMC3429964
  • [Keywords] NOTNLM ; Epithelial salivary gland tumors / major salivary gland tumors / minor salivary gland tumors / salivary gland
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32. Ali NS, Nawaz A, Rajput S, Ikram M: Parotidectomy: a review of 112 patients treated at a teaching hospital in Pakistan. Asian Pac J Cancer Prev; 2010;11(4):1111-3
MedlinePlus Health Information. consumer health - After Surgery.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • RESULTS: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors.
  • The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%).
  • High grade or advanced tumour is a predictor of poor outcome which may require adjuvant therapy.
  • [MeSH-major] Adenoma / surgery. Carcinoma / surgery. Facial Paralysis / etiology. Parotid Neoplasms / surgery. Postoperative Complications

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  • (PMID = 21133633.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Thailand
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33. Ansari MH: Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg; 2007 Nov;65(11):2187-94
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.
  • PURPOSE: Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia.
  • In the absence of epidemiologic studies of these neoplasms in an Iranian population, we conducted a preliminary survey of 130 cases over the last 20 years in Hamedan, Iran.
  • PATIENTS AND METHODS: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003.
  • This review found 89 patients with benign tumors and 41 patients with malignant tumors.
  • The collection of data included gender, age, location, and histopathology of the tumor.
  • Patients with benign and malignant tumors presented with a mean age of 41.3 and 47 years, respectively.
  • The frequency of benign tumors was 68.4% (n = 89) and 31.6% for malignant tumors (n = 41).
  • Tumors were localized in the parotid gland (63%; n = 82), the submandibular gland (23%; n = 30), and in the minor salivary glands (14%; n = 18).
  • The most common benign tumor was pleomorphic adenoma (65.4%; n = 85).
  • Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n = 15), followed by adenocarcinoma (10%; n = 13).
  • Greater than 63% of malignant tumors were treated surgically, and the remaining with combined therapy.
  • Seven patients died over the follow-up period (6 with persistent disease), 5 were lost to follow-up, and 23 remained cancer-free.
  • CONCLUSION: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously.
  • In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology
  • [MeSH-minor] Adenocarcinoma / epidemiology. Adenoma, Pleomorphic / epidemiology. Adolescent. Adult. Aged. Carcinoma, Mucoepidermoid / epidemiology. Disease-Free Survival. Female. Follow-Up Studies. Humans. Iran / epidemiology. Male. Middle Aged. Neoadjuvant Therapy. Parotid Neoplasms / epidemiology. Retrospective Studies. Salivary Glands, Minor / pathology. Submandibular Gland Neoplasms / epidemiology. Survival Rate

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  • (PMID = 17954313.001).
  • [ISSN] 0278-2391
  • [Journal-full-title] Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • [ISO-abbreviation] J. Oral Maxillofac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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34. Ghraïri H, Kartas S, Ammar J, Abid H, Ayadi A, Kilani T, Hamzaoui A: [Prognosis of mucoepidermoid carcinoma of the bronchi]. Rev Pneumol Clin; 2007 Feb;63(1):29-34
Genetic Alliance. consumer health - Mucoepidermoid carcinoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Prognosis of mucoepidermoid carcinoma of the bronchi].
  • BACKGROUND: Mucoepidermoid cancer is exceptional in the respiratory tract, accounting for only 0.2% of primary lung cancers.
  • CASE REPORTS: We report three cases of mucoepidermoid carcinoma.
  • Bronchial fibroscopy disclosed a proximal endobronchial tumor in all three patients.
  • Pathology study of the operative specimen identified low-grade malignant mucoepidermoid carcinoma in the two children and high-grade malignant mucoepidermoid carcinoma in the adult.
  • DISCUSSION: The prognosis of mucoepidermoid tumors of the bronchi is closely related to tumor grade and extension at diagnosis.
  • Unlike high-grade mucoepidermoid carcinoma, the progression of low-grade tumors, which predominate in children, is generally slow, enabling good prognosis if diagnosis is established early.
  • Early search for these tumors in patients presenting chronic or recurrent respiratory manifestations would avoid late diagnosis and improve prognosis.
  • [MeSH-major] Bronchial Neoplasms. Carcinoma, Mucoepidermoid
  • [MeSH-minor] Adolescent. Adult. Bronchi / pathology. Bronchoscopy. Child. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Prognosis. Radiography, Thoracic. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 17457281.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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35. Buchner A, Merrell PW, Carpenter WM: Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med; 2007 Apr;36(4):207-14
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world.
  • BACKGROUND: The relative frequency of individual intra-oral minor salivary gland tumors (IMSGT) is not well documented in the literature.
  • Tumors were classified according to the 2005 WHO classification of salivary gland tumors.
  • Of the 380 tumors, 224 (59%) were benign and 156 (41%) were malignant.
  • Of the benign tumors, pleomorphic adenoma (PA) was the most common (39.2%), followed by cystadenoma (6.3%), canalicular adenoma (6.1%), ductal papillomas (4.4%), basal cell adenoma (1.6%), and myoepithelioma (1.3%).
  • Of the malignant tumors, mucoepidermoid carcinoma was the most common (21.8%), followed by polymorphous low-grade adenocarcinoma (7.1%), adenoid cystic carcinoma (6.3%), adenocarcinoma, not otherwise specified (NOS; 2.1%), acinic cell carcinoma (1.6%), clear cell carcinoma, NOS (1.0%), and carcinoma ex PA (0.5%).
  • CONCLUSIONS: Studies related to the relative frequency of individual IMSGTs from different parts of the world are difficult to compare because many studies are outdated, the number of cases is small, the list of tumors is limited, and new entities are not included.
  • To determine the true relative frequency, more studies should be conducted, on a large number of cases from one source, by experienced pathologists in the field of salivary gland tumors.
  • [MeSH-major] Salivary Gland Neoplasms / epidemiology. Salivary Glands, Minor / pathology
  • [MeSH-minor] Adenoma, Pleomorphic / epidemiology. Adenoma, Pleomorphic / pathology. Adolescent. Adult. Aged. Aged, 80 and over. California / epidemiology. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / pathology. Carcinoma, Mucoepidermoid / epidemiology. Carcinoma, Mucoepidermoid / pathology. Child. Cystadenoma / epidemiology. Cystadenoma / pathology. Female. Humans. Male. Middle Aged. Prevalence

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  • (PMID = 17391298.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
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36. Boffano P, Cassarino E, Zavattero E, Campisi P, Garzino-Demo P: Surgical treatment of glandular odontogenic cysts. J Craniofac Surg; 2010 May;21(3):776-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Glandular odontogenic cyst (GOC) is an unusual entity of jaws, which shows features that overlap with botryoid odontogenic cyst and mucoepidermoid tumor.
  • Glandular odontogenic cyst has an uncertain histogenesis and was recently listed by the World Health Organization as a developmental odontogenic epithelial cyst: it is characterized by an epithelial lining with cuboidal or columnar cells, both at the surface and lining, with crypts or cystlike spaces within the thickness of the epithelium.

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  • (PMID = 20485046.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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37. Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. EMBO J; 2005 Jul 6;24(13):2391-402
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Salivary gland tumors, a group of histologically diverse benign and malignant neoplasms, represent a challenging problem for diagnosis and treatment.
  • A specific recurring t(11;19)(q21;p13) translocation is associated with two types of salivary gland tumors, mucoepidermoid carcinomas and Warthin's tumors.
  • This translocation generates a fusion protein comprised of the N-terminal CREB (cAMP response element-binding protein)-binding domain of the CREB regulator MECT1 (Mucoepidermoid carcinoma translocated-1) and the C-terminal transcriptional activation domain of the Notch coactivator Mastermind-like 2 (MAML2).
  • This study has identified a novel, critical mechanism of transformation for an oncogene associated very specifically with salivary gland tumors, and identified potential targets for the development of novel therapies.

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  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
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  • (PMID = 15961999.001).
  • [ISSN] 0261-4189
  • [Journal-full-title] The EMBO journal
  • [ISO-abbreviation] EMBO J.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA036167; United States / NCI NIH HHS / CA / R01 CA097148; United States / NCI NIH HHS / CA / R37 CA036167
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CREB1 protein, human; 0 / Cyclic AMP Response Element-Binding Protein; 0 / MECT1-MAML2 fusion protein, human; 0 / Nuclear Proteins; 0 / Oncogene Proteins, Fusion; 0 / Trans-Activators; 0 / Transcription Factors; E0399OZS9N / Cyclic AMP
  • [Other-IDs] NLM/ PMC1173159
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38. Takahama Junior A, Almeida OP, Kowalski LP: Parotid neoplasms: analysis of 600 patients attended at a single institution. Braz J Otorhinolaryngol; 2009 Jul-Aug;75(4):497-501

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Parotid neoplasms: analysis of 600 patients attended at a single institution.
  • Salivary gland tumors are rare, generally benign and affect mainly the parotid gland.
  • AIM: The purpose of this study was to retrospectively analyze all cases of parotid tumors treated at our institution from 1953 to 2003.
  • METHODS: All patients with primary parotid tumors were selected; clinical and histopathological data were analyzed and described.
  • RESULTS: 600 cases of parotid tumors were selected; 369 were benign and 231 were malignant.
  • Pleomorphic adenoma was the most frequent benign tumor.
  • The most common malignant tumor was the mucoepidermoid carcinoma.
  • Adjuvant therapy -- mainly radiotherapy -- was used in some cases with malignant tumors.
  • The incidences of local, regional and distant recurrences of malignant tumors were 10%, 8% and 9%.
  • CONCLUSION: Patients with parotid tumors treated at our institution were mainly adults, with marginally more female patients.
  • Benign tumors were mostly the pleomorphic adenoma, which were more frequent than malignancies.
  • Adjuvant therapy, mainly radiotherapy, was used in selected malignant cases.
  • [MeSH-major] Adenoma, Pleomorphic / surgery. Carcinoma, Mucoepidermoid / surgery. Parotid Neoplasms / surgery
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Recurrence, Local. Neoplasm Staging. Retrospective Studies. Treatment Outcome

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  • (PMID = 19784416.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
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