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1. Lah JJ, Kuo JV, Chang KJ, Nguyen PT: EUS-guided brachytherapy. Gastrointest Endosc; 2005 Nov;62(5):805-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [MeSH-major] Brachytherapy. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / secondary. Endosonography. Esophageal Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Female. Humans. Lymph Nodes / pathology. Lymph Nodes / radiation effects. Lymphatic Metastasis. Neoplasm Recurrence, Local

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  • [CommentIn] Gastrointest Endosc. 2005 Nov;62(5):808-10 [16246707.001]
  • (PMID = 16246706.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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2. D'Agostino M, Cinelli C, Willard R, Hofmann J, Jellinek N, Robinson-Bostom L: Epidermotropic Merkel cell carcinoma: a case series with histopathologic examination. J Am Acad Dermatol; 2010 Mar;62(3):463-8
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  • [Title] Epidermotropic Merkel cell carcinoma: a case series with histopathologic examination.
  • BACKGROUND: Merkel cell carcinoma (MCC), an aggressive malignancy that has been increasing in incidence, rarely presents with an epidermotropic pattern.
  • In cases 1, 3, and 6, the perinuclear dot pattern observed with cytokeratin-20 in the epidermotropic MCC cells was less pronounced than the pattern observed in the dermis, and in all 6 of the tumors, the epidermal staining pattern observed with epithelial membrane antigen was not more or less prominent than the staining observed in the dermis.
  • CONCLUSION: The data presented reinforce the differential diagnosis of tumors with an epidermotropic growth pattern and the importance of immunohistochemical staining in the histologic workup of such tumors: squamous cell carcinoma in situ, melanoma, mycosis fungoides, eccrine porocarcinoma, sebaceous carcinoma of the eyelid, mammary and extramammary Paget disease, MCC, and epidermotropic metastases.
  • It is notable that 3 of 6 identified tumors were located on the eyelid; further study of epidermotropic MCC may shed more light on this finding, either as an unusual coincidence or a finding with unexplained significance.
  • [MeSH-major] Carcinoma, Merkel Cell / pathology. Eyelid Neoplasms / pathology

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  • [Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
  • (PMID = 20159312.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Chromogranin A; 0 / Keratin-20
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3. Nishimura G, Horiuchi C, Yoshida T, Kawakami M, Yabuki K, Taguchi T, Nagao J, Kondo N, Masuda Y, Matsuda H, Mikami Y, Tsukuda M: [Change of creatinine clearance rate in accordance with aging in Japanese patients with head and neck cancer]. Gan To Kagaku Ryoho; 2006 Apr;33(4):463-6
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  • Most of the head and neck tumors are squamous cell carcinomas (SCCs), which are relatively sensitive to chemotherapeutic agents.
  • The incident rate of end-stage renal disease is 1.3 times higher in the United States than in Japan.
  • [MeSH-major] Aging / physiology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / physiopathology. Creatinine / blood. Head and Neck Neoplasms / physiopathology. Kidney Function Tests


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4. Stratton SP, Alberts DS, Einspahr JG, Sagerman PM, Warneke JA, Curiel-Lewandrowski C, Myrdal PB, Karlage KL, Nickoloff BJ, Brooks C, Saboda K, Yozwiak ML, Krutzsch MF, Hu C, Lluria-Prevatt M, Dong Z, Bowden GT, Bartels PH: A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer. Cancer Prev Res (Phila); 2010 Feb;3(2):160-9
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  • The chemopreventive and antitumor properties of perillyl alcohol (POH) that were studied preclinically indicate that topical POH inhibits both UVB-induced murine skin carcinogenesis (squamous cell tumor models) and 7,12-dimethylbenz(a)anthracene-induced murine melanoma (transgenic models involving tyrosinase-driven Ras).
  • There was a borderline reduction in the histopathologic score of the lower-dose POH group compared with the placebo (P = 0.1), but this was not observed in the high-dose group.
  • No changes were observed in p53 expression, cellular proliferation (by proliferating cell nuclear antigen expression), or apoptosis in either treatment group compared with the placebo group.

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  • [CommentIn] Cancer Prev Res (Phila). 2010 Feb;3(2):132-5 [20103730.001]
  • (PMID = 20103724.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30 CA023074; United States / NCI NIH HHS / CA / P01 CA027502-25; United States / NCI NIH HHS / CA / CA027502; United States / NCI NIH HHS / CA / P30 CA023074-28; United States / NCI NIH HHS / CA / CA023074; United States / NCI NIH HHS / CA / CA027502-25; United States / NCI NIH HHS / CA / P01 CA027502
  • [Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Chromatin; 0 / Monoterpenes; 319R5C7293 / perilla alcohol
  • [Other-IDs] NLM/ NIHMS161246; NLM/ PMC3270887
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5. Krahl D, Sellheyer K: Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma. J Cutan Pathol; 2007 Oct;34(10):782-7
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  • [Title] Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma.
  • BACKGROUND: Sclerosing cutaneous neoplasms often represent a diagnostic challenge.
  • It is diagnostically highly reliable in the differentiation between basal cell carcinoma and cutaneous squamous cell carcinoma.
  • In this study, we report its application in the differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and basal cell carcinoma.
  • METHODS: Biopsy samples from 28 sclerosing and infiltrating basal cell carcinomas, 13 microcystic adnexal carcinomas and 16 desmoplastic trichoepitheliomas were examined after immunohistochemical staining with Ber-EP4.
  • RESULTS: Ber-EP4 did not label any of the microcystic adnexal carcinomas, whereas all 28 basal cell carcinomas were Ber-EP4 positive.
  • Only one basal cell carcinoma was weakly positive.
  • Twelve of the 16 desmoplastic trichoepitheliomas were immunoreactive with Ber-EP4 and the staining was more variable than those of basal cell carcinomas.
  • CONCLUSIONS: Ber-EP4 reliably differentiates microcystic adnexal carcinoma from basal cell carcinoma to the same extent as it distinguishes the latter tumor from squamous cell carcinoma.
  • While it stains the majority of desmoplastic trichoepitheliomas, these tumors still have to be considered in the differential diagnosis with microcystic adnexal carcinoma, when Ber-EP4 is applied.
  • [MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / diagnosis. Carcinoma, Skin Appendage / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Humans. Sclerosis / pathology


6. Mopuri N, Laitung JK, Cardozo C: Collision tumour of squamous cell carcinoma and invasive malignant melanoma of scalp - a case report. J Plast Reconstr Aesthet Surg; 2009 May;62(5):e104-5
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  • [Title] Collision tumour of squamous cell carcinoma and invasive malignant melanoma of scalp - a case report.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Melanoma / pathology. Neoplasms, Multiple Primary / pathology. Scalp. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Humans. Male. Neoplasm Invasiveness


7. Pfeifer GP, Rauch TA: DNA methylation patterns in lung carcinomas. Semin Cancer Biol; 2009 Jun;19(3):181-7
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  • The genome of epithelial tumors is characterized by numerous chromosomal aberrations, DNA base sequence changes, and epigenetic abnormalities.
  • In squamous cell carcinomas of the lung, CpG methylation patterns undergo substantial changes relative to normal lung epithelium.
  • Interestingly, a large fraction (almost 80%) of the tumor-specifically methylated sequences are targets of the Polycomb complex in embryonic stem cells.
  • Homeobox genes are particularly overrepresented and all four HOX gene loci on chromosomes 2, 7, 12, and 17 are hotspots for tumor-associated methylation because of the presence of multiple methylated CpG islands within these loci.
  • DNA hypomethylation at CpGs in squamous cell tumors preferentially affects repetitive sequence classes including SINEs, LINEs, subtelomeric repeats, and segmental duplications.
  • Since these epigenetic changes are found in early stage tumors, their contribution to tumor etiology as well as their potential usefulness as diagnostic or prognostic biomarkers of the disease should be considered.

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  • (PMID = 19429482.001).
  • [ISSN] 1096-3650
  • [Journal-full-title] Seminars in cancer biology
  • [ISO-abbreviation] Semin. Cancer Biol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA084469; None / None / / R21 CA128495-02; United States / NCI NIH HHS / CA / CA084469; United States / NCI NIH HHS / CA / R01 CA084469-09; United States / NCI NIH HHS / CA / CA128495; None / None / / R01 CA084469-09; United States / NCI NIH HHS / CA / R21 CA128495-02; United States / NCI NIH HHS / CA / R21 CA128495
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Polycomb-Group Proteins; 0 / Repressor Proteins
  • [Number-of-references] 85
  • [Other-IDs] NLM/ NIHMS96703; NLM/ PMC2680753
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8. Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med; 2006 Dec 14;355(24):2542-50
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  • [Title] Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.
  • METHODS: Between July 2001 and April 2004, the Eastern Cooperative Oncology Group (ECOG) conducted a randomized study in which 878 patients with recurrent or advanced non-small-cell lung cancer (stage IIIB or IV) were assigned to chemotherapy with paclitaxel and carboplatin alone (444) or paclitaxel and carboplatin plus bevacizumab (434).
  • Chemotherapy was administered every 3 weeks for six cycles, and bevacizumab was administered every 3 weeks until disease progression was evident or toxic effects were intolerable.
  • Patients with squamous-cell tumors, brain metastases, clinically significant hemoptysis, or inadequate organ function or performance status (ECOG performance status, >1) were excluded.
  • The median progression-free survival in the two groups was 6.2 and 4.5 months, respectively (hazard ratio for disease progression, 0.66; P<0.001), with corresponding response rates of 35% and 15% (P<0.001).
  • CONCLUSIONS: The addition of bevacizumab to paclitaxel plus carboplatin in the treatment of selected patients with non-small-cell lung cancer has a significant survival benefit with the risk of increased treatment-related deaths. (ClinicalTrials.gov number, NCT00021060. )
  • [MeSH-major] Angiogenesis Inhibitors / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Aged. Antibodies, Monoclonal, Humanized. Bevacizumab. Carboplatin / administration & dosage. Carboplatin / adverse effects. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Paclitaxel / administration & dosage. Paclitaxel / adverse effects. Vascular Endothelial Growth Factor A / blood

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  • [Copyright] 2006 Massachusetts Medical Society
  • [CommentIn] N Engl J Med. 2007 Mar 29;356(13):1373; author reply 1374-5 [17396305.001]
  • [CommentIn] N Engl J Med. 2007 Mar 29;356(13):1373; author reply 1374-5 [17392310.001]
  • [CommentIn] N Engl J Med. 2007 Mar 29;356(13):1374; author reply 1374-5 [17396304.001]
  • [CommentIn] N Engl J Med. 2007 Mar 29;356(13):1373-4; author reply 1374-5 [17396306.001]
  • [ErratumIn] N Engl J Med. 2007 Jan 18;356(3):318
  • (PMID = 17167137.001).
  • [ISSN] 1533-4406
  • [Journal-full-title] The New England journal of medicine
  • [ISO-abbreviation] N. Engl. J. Med.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00021060
  • [Grant] United States / NCI NIH HHS / CA / CA12046; United States / NCI NIH HHS / CA / CA14548; United States / NCI NIH HHS / CA / CA16116; United States / NCI NIH HHS / CA / CA21076; United States / NCI NIH HHS / CA / CA21115; United States / NCI NIH HHS / CA / CA23318; United States / NCI NIH HHS / CA / CA31946; United States / NCI NIH HHS / CA / CA49957; United States / NCI NIH HHS / CA / CA66636
  • [Publication-type] Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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9. Aréchaga-Ocampo E, Pereira-Suárez AL, del Moral-Hernández O, Cedillo-Barrón L, Rodríguez-Sastre MA, Castillo-Alvarez A, López-Bayghen E, Villegas-Sepúlveda N: HPV+ cervical carcinomas and cell lines display altered expression of caspases. Gynecol Oncol; 2008 Jan;108(1):10-8
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  • [Title] HPV+ cervical carcinomas and cell lines display altered expression of caspases.
  • OBJECTIVE: Loss of expression of apoptotic regulatory proteins in many neoplasias might result in defective or delayed apoptosis, thus facilitating tumor growth or survival.
  • We analyzed here, the basal expression of precursors of apoptotic Caspases in normal cervical epithelium, HPV+ cervical tumor samples and HPV+ tumor-derived cell lines.
  • METHODS: Expression of initiator and effector Caspases was analyzed by immunochemistry in normal cervical epithelium and three types of cervical tumors (squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma) whereas expression of Caspases in HeLa, SiHa and CaSki cells was by immunofluorescence, Western blot and RT-PCR.
  • RESULTS: Expression of Caspases 3 and 9 was undetectable in adenocarcinoma and adenosquamous cell carcinoma, respectively.
  • Whereas in squamous cell carcinoma, the expression of Caspases was similar those observed in normal samples.
  • Expression of Caspases 3 and 6 was low in HeLa and CaSki cells, while Caspase 8 was low in SiHa and it was not detected in C33-A cells.
  • We did not observe an effect of the E6/E7 oncogenes on the expression of Caspases in C33-A cell.
  • CONCLUSION: Our results showed a differential expression of several Caspases in carcinoma samples and cell lines, suggesting multiple alterations of the Caspase pathways in cervical cancer.
  • [MeSH-major] Caspases / biosynthesis. Papillomavirus Infections / enzymology. Uterine Cervical Neoplasms / enzymology. Uterine Cervical Neoplasms / virology
  • [MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Adenocarcinoma / virology. Blotting, Western. Carcinoma, Adenosquamous / enzymology. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / virology. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Cell Line, Tumor. Female. Fluorescent Antibody Technique. HeLa Cells. Human papillomavirus 16. Human papillomavirus 18. Humans. Immunohistochemistry. Isoenzymes / biosynthesis. Paraffin Embedding. Reverse Transcriptase Polymerase Chain Reaction

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  • (PMID = 17936882.001).
  • [ISSN] 1095-6859
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Isoenzymes; EC 3.4.22.- / Caspases
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10. Safranek PM, Sujendran V, Baron R, Warner N, Blesing C, Maynard ND: Oxford experience with neoadjuvant chemotherapy and surgical resection for esophageal adenocarcinomas and squamous cell tumors. Dis Esophagus; 2008;21(3):201-6
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  • [Title] Oxford experience with neoadjuvant chemotherapy and surgical resection for esophageal adenocarcinomas and squamous cell tumors.
  • Since February 2000 it has been our practice to offer this chemotherapy regime to patients with T2 and T3 or T1N1 tumors.
  • Six patients (5.7%) had progressive disease and were inoperable (discovered in four at surgery).
  • A total of 182 patients with a median age of 63 (range 30-80), 41 squamous and 141 adenocarcinomas underwent surgery.
  • A radical surgical approach to the primary tumor in combination with OEO2 neoadjuvant chemotherapy has led to a high R0 resection rate and good survival with acceptable morbidity and mortality.

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  • (PMID = 18430099.001).
  • [ISSN] 1442-2050
  • [Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
  • [ISO-abbreviation] Dis. Esophagus
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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11. Elamin I, Zecević RD, Vojvodić D, Medenica L, Pavlović MD: Cytokine concentrations in basal cell carcinomas of different histological types and localization. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Jun;17(2):55-9
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  • [Title] Cytokine concentrations in basal cell carcinomas of different histological types and localization.
  • BACKGROUND: Basal cell carcinoma (BCC) is the most common malignant skin tumor.
  • Cytokines as major mediators of the immune system have been shown to play an important role in biology of the neoplasm with the general predomination of Th2 cytokines, whereas IFN-?
  • and other Th1 cytokines are prevalent in spontaneously regressing tumors.
  • OBJECTIVE: We were interested in comparing cytokine levels in BCC and cutaneous squamous cell tumors with BCC of different localization and histological subtypes.
  • MATERIAL AND METHODS: Explants from freshly excised BCC from 18 patients, and cutaneous squamous cell tumors (solar keratoses and Bowen's disease) from 9 patients were cultivated for 24 h.
  • RESULTS: Tissue explants of BCC contained significantly higher concentrations of IL-1beta, IL-4, IL-5, and IL-6 compared to those of squamous cell tumors.
  • Higher levels of TNF-alpha (p = 0.042), IL-4 (p = 0.028), and IL-5 (p = 0.012) were found in tumors localized to the head and neck compared to those on the trunk or extremities.
  • Interleukin-6 concentrations were higher in aggressive BCC variants (infiltrative and micronodular), but the difference was not statistically significant (p = 0.068).
  • CONCLUSIONS: Confirming the earlier findings that BCC is a tumor with a Th2 cytokine microenvironment, this study further shows that BCC situated on the head and neck produce even more of certain Th2 cytokines (IL-4 and IL-5) and TNF-alpha, a crucial immunosuppressive cytokine released upon UVB irradiation.
  • [MeSH-major] Carcinoma, Basal Cell / chemistry. Cytokines / analysis. Skin Neoplasms / chemistry
  • [MeSH-minor] Aged. Carcinoma, Squamous Cell / chemistry. Female. Humans. Interleukin-4 / analysis. Interleukin-5 / analysis. Male. Tumor Necrosis Factor-alpha / analysis

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  • (PMID = 18709290.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovenia
  • [Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-5; 0 / Tumor Necrosis Factor-alpha; 207137-56-2 / Interleukin-4
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12. Jacob S, Mohapatra D: Placental site nodule: a tumor-like trophoblastic lesion. Indian J Pathol Microbiol; 2009 Apr-Jun;52(2):240-1
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  • [Title] Placental site nodule: a tumor-like trophoblastic lesion.
  • This entity may have bizarre histologic findings and should be distinguished from other aggressive lesions like placental site trophoblastic tumor, epithelioid trophoblastic tumor and squamous cell carcinoma.
  • [MeSH-major] Gestational Trophoblastic Disease / diagnosis. Placenta Diseases / pathology. Trophoblasts / pathology

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  • (PMID = 19332926.001).
  • [ISSN] 0974-5130
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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13. Gómez de la Fuente E, Sols M, Pinedo F, Alvarez-Fernández JG, Vicente FJ, Naz E, López-Estebaranz JL: [Atypical fibroxanthoma. Clinical/pathological study of 10 cases]. Actas Dermosifiliogr; 2005 Apr;96(3):153-8
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  • [Transliterated title] Fibroxantoma atípico. Estudio clinicopatológico de 10 casos.
  • INTRODUCTION: Atypical fibroxanthoma (AFX) is a rare tumor of unknown histogenesis, considered by most authorities as a superficial form of malignant fibrous histiocytoma (MFH).
  • Clinical (age, onset-diagnosis time, location, accompanying pathology, outcome), histological (architectural pattern, cell type, ulceration, vascular or perineural invasion, subcutis involvement, pleomorphism, mitosis, inflammatory infiltrate) and immunohistochemical variable were analyzed.
  • Pathologically all the cases showed a spindle-cell prevalence arranged in a vaguely storiform pattern, along with both, multinucleated and eosinophilic cells.
  • Other spindle-cell tumors such as squamous cell carcinoma, malignant melanoma, leyomiosarcoma or dermatofibrosarcoma protuberans must be ruled out by immunohistochemical techniques.
  • [MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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  • (PMID = 16476356.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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14. Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, McGinn TG, Wisnivesky JP: Racial disparities in esophageal cancer treatment and outcomes. Ann Surg Oncol; 2008 Mar;15(3):881-8
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  • Blacks were more likely to be diagnosed at a more advanced stage and to have squamous cell tumors, but were less likely to undergo surgery.
  • In multivariate regression controlling for age, sex, marital status, histology, and tumor location, black race was associated with worse survival.
  • When tumor status, surgery, and radiotherapy were added to the model, race was no longer significantly associated with survival.
  • While the disparity is due in part to differences in tumor histology, diagnosis at an earlier stage and higher rates of surgery among blacks could reduce this survival disparity.
  • [MeSH-major] Adenocarcinoma / ethnology. Carcinoma, Squamous Cell / ethnology. Esophageal Neoplasms / ethnology. Esophageal Neoplasms / therapy. Healthcare Disparities


15. Demarosi F, Lodi G, Carrassi A, Soligo D, Sardella A: Oral malignancies following HSCT: graft versus host disease and other risk factors. Oral Oncol; 2005 Oct;41(9):865-77
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  • [Title] Oral malignancies following HSCT: graft versus host disease and other risk factors.
  • Allogenic hematopoietic stem cell transplantation (HSCT), a procedure that is widely used in the treatment of a large number of malignant and non-malignant hematological diseases, is still associated with a wide range of complications, one of the most important of which is graft versus host disease (GVHD).
  • The patients undergoing allogenic HSCT are also at high risk of developing secondary neoplasms, particularly leukemias and lymphomas.
  • Solid tumors are less frequent, and the incidence appears to increase over time; the most frequent solid tumors are squamous cell carcinomas.
  • They include graft versus host disease (GVHD), preoperative regimens, with either radio-chemotherapy or chemotherapy alone, conditioning regimes, immunosuppressive GVHD prophylaxis, viral infection and chronic stimulation as a result of viral antigens, antigenic stimulation from histocompatibility differences between recipient and donor, primary diagnosis, interaction of any of these factors with genetic predisposition, and other factors such as sex and age.
  • All patients treated with HSCT should therefore be closely followed over the long term with the aim of identifying the onset of secondary tumors as early as possible.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Graft vs Host Disease / etiology. Hematopoietic Stem Cell Transplantation / adverse effects. Mouth Neoplasms / etiology. Neoplasms, Second Primary / etiology

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  • (PMID = 16084755.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 39
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16. Matsumoto K, Hyodo F, Matsumoto A, Koretsky AP, Sowers AL, Mitchell JB, Krishna MC: High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents. Clin Cancer Res; 2006 Apr 15;12(8):2455-62
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  • [Title] High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.
  • The levels of 3CP were examined by EPRI and MRI for differences in reduction between muscle and tumor (squamous cell carcinoma) implanted in the hind leg of C3H mice simultaneously.
  • The tumor regions exhibited a faster decay rate of the nitroxide compared to muscle (0.097 min(-1) versus 0.067 min(-1), respectively).
  • [MeSH-major] Magnetic Resonance Imaging / methods. Neoplasms, Experimental / pathology. Nitrogen Oxides / chemistry
  • [MeSH-minor] Animals. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Cyclic N-Oxides / chemistry. Cyclic N-Oxides / metabolism. Electron Spin Resonance Spectroscopy / methods. Female. Mice. Mice, Inbred C3H. Models, Chemical. Muscles / metabolism. Oxidation-Reduction. Pyrrolidines / chemistry. Pyrrolidines / metabolism

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  • (PMID = 16638852.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Grant] United States / Intramural NIH HHS / / Z01 NS003047-01
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cyclic N-Oxides; 0 / Nitrogen Oxides; 0 / Pyrrolidines; 14332-28-6 / nitroxyl; 4399-80-8 / 3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-N-oxyl
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17. Wilson MK, Granger EK, Preda VA: Pulmonary hypertension due to isolated metastatic squamous cell carcinoma thromboemboli. Heart Lung Circ; 2006 Apr;15(2):143-5
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  • [Title] Pulmonary hypertension due to isolated metastatic squamous cell carcinoma thromboemboli.
  • The differential diagnosis of pulmonary hypertension due to arterial tumour embolism is often overlooked and deserves contemplation.
  • This resulted in the surprising definitive diagnosis of thromboembolic pulmonary hypertension secondary to laminated thrombi of metastatic squamous cell tumour emboli.
  • The site of tumour origin was however not histologically apparent and was unable to be elucidated on extensive further investigation.
  • [MeSH-major] Arterial Occlusive Diseases / diagnosis. Hypertension, Pulmonary / diagnosis. Neoplasms, Squamous Cell / diagnosis. Pulmonary Embolism / diagnosis. Thromboembolism / diagnosis


18. Fuld AD, Dragnev KH, Rigas JR: Pemetrexed in advanced non-small-cell lung cancer. Expert Opin Pharmacother; 2010 Jun;11(8):1387-402
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  • [Title] Pemetrexed in advanced non-small-cell lung cancer.
  • IMPORTANCE OF THE FIELD: Current therapeutic options for advanced non-small-cell lung cancer (NSCLC) yield relatively modest improvements in survival leading to an ongoing search for new active treatment agents.
  • The efficacy of pemetrexed seems to vary between squamous and nonsquamous histologies.
  • There is growing evidence that, in patients treated with pemetrexed, nonsquamous tumors have improved outcomes compared to squamous cell tumors.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Glutamates / therapeutic use. Guanine / analogs & derivatives. Lung Neoplasms / drug therapy
  • [MeSH-minor] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Clinical Trials, Phase II as Topic. Clinical Trials, Phase III as Topic. Humans. Pemetrexed. Survival Rate. Treatment Outcome


19. Yilmaz A, Savaş I, Dizbay Sak S, Güngör A, Kaya A, Serinsöz E, Savaş B: Distribution of Bcl-2 gene expression and its prognostic value in non-small cell lung cancer. Tuberk Toraks; 2005;53(4):323-9
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  • [Title] Distribution of Bcl-2 gene expression and its prognostic value in non-small cell lung cancer.
  • The aim of this study was to determine the expression of Bcl-2 gene and prognostic importance of Bcl-2 expression in paraffin embedded blocks of patients diagnosed with non-small cell lung cancer (NSCLC).
  • These sections are transferred on to slides covered with poly-L-lysine, then de-paraffinization was made.
  • Positive staining was observed in 9 (19.6%) patients, but not in 37 (80.4%) patients.
  • Out of 32 cases with squamous cell tumor, 8 (25%) were observed to have positive staining in their sections, but 24 (75%) were not so.
  • No staining was observed in 11 cases whose cell type was adenoma and two cases whose cell type was adenosquamos (100%).
  • Staining was present in the section of one case with large cell (100%).
  • Median survival time was 36.6 months in cases in which staining was observed and 6.10 months in cases in which staining was not observed, with a significant difference (p< 0.05).
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / genetics. Gene Expression Regulation, Neoplastic. Genes, bcl-2. Lung Neoplasms / genetics. Proto-Oncogene Proteins c-bcl-2 / biosynthesis
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate


20. Pajor A, Stańczyk R, Durko T: [Malignant neoplasms of external and middle ear]. Otolaryngol Pol; 2005;59(2):251-6
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  • [Title] [Malignant neoplasms of external and middle ear].
  • [Transliterated title] Nowotwory złośliwe ucha zewnetrznego i środkowego.
  • INTRODUCTION: Neoplasms of external and middle ear are rare, which cause several problems in diagnosis and therapy.
  • The purpose of the study was to analyze retrospectively patients with malignant neoplasms of the ear.
  • METHODOLOGY: The study was carried out on 53 patients treated for malignant ear neoplasms in single institution during 25 years (1978-2002).
  • RESULTS: The most frequent neoplasm was squamous cell carcinoma--36 cases (67.9%), then basal cell carcinoma--9 cases (16.9%).
  • Neoplasm primarily involved auricle in 26 patients (49.1%), external auditory canal in 15 patients (28.3%) and middle ear in 12 patients (22.6%).
  • The characteristics of neoplasms related to the site of location were described.
  • The difficulties in precise histopathologic diagnosis and extent of disease were pointed out.
  • RESULTS: Neoplasms of external and middle ear constitute a group of various histopathological and clinical tumours, which differ in diagnostic difficulties, treatment and prognosis.
  • A diagnosis was often made in advanced stages of neoplasms, especially for middle ear tumours, that diminished a possibility of effective treatment.
  • [MeSH-major] Ear Neoplasms / pathology. Ear, External. Ear, Middle
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Ossicular Prosthesis. Retrospective Studies

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  • (PMID = 16095097.001).
  • [ISSN] 0030-6657
  • [Journal-full-title] Otolaryngologia polska = The Polish otolaryngology
  • [ISO-abbreviation] Otolaryngol Pol
  • [Language] pol
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Poland
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21. Zhang LN, Xiao ZP, Ding H, Ge HM, Xu C, Zhu HL, Tan RX: Synthesis and cytotoxic evaluation of novel 7-O-modified genistein derivatives. Chem Biodivers; 2007 Feb;4(2):248-55
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  • The cytotoxic activities of these compounds were evaluated against human chronic myeloid leukemia cells (K562) and a human nasopharyngeal epidermoid tumor cell line (KB).

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  • (PMID = 17311236.001).
  • [ISSN] 1612-1880
  • [Journal-full-title] Chemistry & biodiversity
  • [ISO-abbreviation] Chem. Biodivers.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Antineoplastic Agents; DH2M523P0H / Genistein
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22. Lo WC, Ting LL, Ko JY, Lou PJ, Yang TL, Chang YL, Wang CP: Malignancies of the ear in irradiated patients of nasopharyngeal carcinoma. Laryngoscope; 2008 Dec;118(12):2151-5
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  • RESULTS: Ten tumors were squamous cell carcinoma and one tumor was chondrosarcoma occurring within the radiation field of previous treatment for NPC.
  • Six tumors were located in the external auditory canal, two in the middle ear cavity, two in the periauricular region and one in the mastoid cavity.
  • The 3-year disease-free and overall survival rates were 30.3% and 20%, respectively.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Chondrosarcoma / etiology. Ear Neoplasms / etiology. Nasopharyngeal Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies

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  • (PMID = 18948828.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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23. Carlson M, Wuertz B, Lin J, Taylor R, Ondrey F: Exons 19 and 21 of epidermal growth factor receptor are highly conserved in squamous cell cancer of the head and neck. Int J Otolaryngol; 2009;2009:649615
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  • [Title] Exons 19 and 21 of epidermal growth factor receptor are highly conserved in squamous cell cancer of the head and neck.
  • EGFR inhibitors might be more effective in patients whose tumors harbor specific EGFR mutations.
  • The presence of specific EFGR mutations is predictive of over a 75% response rate to TKI therapies as compared to 10% in wild type cases of non-small cell lung cancer.
  • Design. DNA was extracted from 20 head and neck squamous cell tumors and 4 squamous cell carcinoma cell lines and sequenced the receptor using published primer pairs.
  • Results. No exon 19 or 21 mutations were found in any of the 20 tumors and 0 of 4 cell lines.
  • Based on the tumor data we would predict that no greater than 8% of head and neck tumors (CI 97.5%) would be likely to harbor either of these mutations.
  • Conclusions. Our findings are comparable to results recently published of Korean, Austrian, and Spanish patient populations and we conclude that exon 19 and 21 EGFR mutations are not more common in head and neck cancer than in nonsmall-cell carcinoma.

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  • (PMID = 20130810.001).
  • [ISSN] 1687-921X
  • [Journal-full-title] International journal of otolaryngology
  • [ISO-abbreviation] Int J Otolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2814135
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24. Pesek M, Benesova L, Belsanova B, Mukensnabl P, Bruha F, Minarik M: Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status. Anticancer Res; 2009 Jul;29(7):2767-73
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  • [Title] Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status.
  • Mutations in EGFR (exon 19 and 21) and KRAS (codons 12 and 13) and their impact on response and survival with respect to tumor subtype and smoking status were assessed.
  • No EGFR effect was recorded for squamous cell tumors.
  • KRAS mutation in tumors did not result in a poorer prognosis in the subtype-selected groups, nor did it present as a negative factor in smokers.
  • KRAS does not seem an "a priori" negative factor for TKI-based treatment of NSCLC.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Genes, ras. Lung Neoplasms / drug therapy. Mutation. Protein Kinase Inhibitors / therapeutic use. Receptor, Epidermal Growth Factor / genetics. Smoking

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  • (PMID = 19596959.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Codon; 0 / DNA Primers; 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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25. Kim Y, Liu XS, Liu C, Smith DE, Russell RM, Wang XD: Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer. Cancer Lett; 2006 Mar 28;234(2):209-19
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer.
  • Results showed that six out 12 ferrets exposed to both NNK injection and cigarette smoke developed grossly identifiable lung tumors whereas none of nine ferrets from the sham treatment group developed any lung lesions.
  • The histopathological types of these tumors (squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma) in ferret lungs are very similar to those in humans.
  • In addition, 10 out of 12 ferrets exposed to both NNK and cigarette smoke developed preneoplastic lesions (squamous metaplasia, dysplasia, and atypical adenomatous hyperplasia) with complex growth patterns whereas the sham group did not show any of these lesions.
  • Furthermore, the expression of proliferating cellular nuclear antigen increased markedly in both gross tumors and preneoplastic lesions in the lungs.
  • In summary, the development of both preneoplastic lesions and gross lung tumors in ferrets provides an excellent and unique model for studying lung cancer chemoprevention with agents such as carotenoids, and for studying the molecular mechanism of carcinogenesis in the earlier stages of smoke-related lung cancer.
  • [MeSH-major] Carcinogens / toxicity. Disease Models, Animal. Ferrets. Lung Neoplasms / etiology. Nitrosamines / toxicity. Smoking / adverse effects
  • [MeSH-minor] Adenocarcinoma / etiology. Adenocarcinoma / pathology. Animals. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Humans. Immunohistochemistry. Male. Precancerous Conditions / etiology. Precancerous Conditions / pathology

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  • (PMID = 15894421.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Grant] United States / NIDDK NIH HHS / DK / T32 DK062032
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Nitrosamines; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
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26. Guimarães Vde C, Viana MA, Barbosa MA, Paiva ML, Tavares JA, Camargo LA: [Vocal care: question of prevention and health]. Cien Saude Colet; 2010 Sep;15(6):2799-803
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  • [Transliterated title] Cuidados vocais: questão de prevenção e saúde.
  • Considering all the patients attended, only one presented malignant neoplasm (squamous cell carcinoma), confirmed later by biopsy.

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  • (PMID = 20922288.001).
  • [ISSN] 1678-4561
  • [Journal-full-title] Ciência & saúde coletiva
  • [ISO-abbreviation] Cien Saude Colet
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
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27. Narumi T, Kozawa E, Heshiki A, Tomoda M, Shimizu Y: CT and MRI findings of a solitary extramedullary plasmacytoma of the oropharynx: case report. Radiat Med; 2005 Dec;23(8):574-7
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  • A mass was endoscopically detected in his right posterior oropharyngeal wall, and biopsy revealed a neoplasm consisting of a uniform population of plasma cells.
  • Computed tomography (CT) showed a broad-based papillary soft tissue density mass projecting into the oropharynx from the right posterior wall of the pharynx, and post-contrast CT showed marked enhancement of the tumor.
  • The tumor showed slightly higher signal intensity compared with surrounding muscle on MR Tl-weighted images (T1WI) and high signal intensity on MR T2-weighted images (T2WI).
  • Following radiation therapy, a reduction in tumor size was observed.
  • Although SEP is a rare tumor, it should be included in the differential diagnosis of tumors of the oropharynx because of its imaging similarities to other, more common malignant tumors, such as squamous cell carcinoma and lymphoma.
  • [MeSH-major] Oropharyngeal Neoplasms / diagnosis. Plasmacytoma / diagnosis

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  • (PMID = 16555568.001).
  • [ISSN] 0288-2043
  • [Journal-full-title] Radiation medicine
  • [ISO-abbreviation] Radiat Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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28. Andratschke M, Stelter K, Ihrler S, Hagedorn H: Subglottic tracheal stenosis as primary manifestation of a marginal zone B-cell lymphoma of the larynx. In Vivo; 2005 May-Jun;19(3):547-50
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  • [Title] Subglottic tracheal stenosis as primary manifestation of a marginal zone B-cell lymphoma of the larynx.
  • BACKGROUND: More than 90% of laryngeal tumors are squamous cell carcinomas.
  • Primary hematopoetic neoplasms of the larynx are rare, being mainly extramedullary plasmocytoma and non-Hodgkin's lymphoma (NHL).
  • The biopsy revealed the diagnosis of a MALT-type lymphoma (marginal zone B-cell lymphoma).
  • [MeSH-major] Laryngeal Neoplasms / diagnosis. Lymphoma, B-Cell, Marginal Zone / diagnosis. Tracheal Stenosis / etiology

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  • (PMID = 15875774.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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29. Ferraz JG, Martins AL, de Souza JF, Matos A, Canto AP, Martins AM: Metastatic tumor of squamous cell carcinoma from uterine cervix to heart: ante-mortem diagnosis. Arq Bras Cardiol; 2006 Oct;87(4):e104-7
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  • [Title] Metastatic tumor of squamous cell carcinoma from uterine cervix to heart: ante-mortem diagnosis.
  • The pathological examination revealed metastasis of squamous cells with well-differentiated infiltrative areas.
  • Four months later, however, she was readmitted to hospital in terminal stage, confirming the guarded prognosis of the disease at this stage.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Heart Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


30. Mandic A, Novakovic P, Mihajlovic O, Stojiljkovic B, Rajovic J, Davidovic M: Clinical staging and histopathological findings after radical hysterectomy in FIGO stage IIB cervical cancer. J BUON; 2008 Jan-Mar;13(1):51-4
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  • The histopathological types of cervical tumors were: squamous cell carcinoma 80%, adenosquamous carcinoma 15% and adenocarcinoma 5%.
  • [MeSH-major] Hysterectomy. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Middle Aged. Neoplasm Staging


31. Shah S, Shukla K, Patel P: Role of fine needle aspiration cytology in diagnosis of lung tumours--a study of 100 cases. Indian J Pathol Microbiol; 2007 Jan;50(1):56-8
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  • The aim of this study was to assess the usefulness of fine needle aspiration cytology (FNAC) as a diagnostic method in lung tumour as well as to determine the incidence of lung cancer in various age and sex group and in relation with smoking.
  • The most common tumour was squamous cell carcinoma (45%) followed by adenocarcinoma (22%), small cell carcinoma (16%) and large cell carcinoma (8%).
  • [MeSH-major] Biopsy, Fine-Needle. Lung Neoplasms / diagnosis
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / epidemiology. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / epidemiology. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / epidemiology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Cytodiagnosis. Female. Histocytochemistry. Humans. Male. Middle Aged. Predictive Value of Tests. Risk Factors. Smoking

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  • (PMID = 17474260.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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32. Marom EM, Martinez CH, Truong MT, Lei X, Sabloff BS, Munden RF, Gladish GW, Herbst RS, Morice RC, Stewart DJ, Jimenez CA, Blumenschein GR Jr, Onn A: Tumor cavitation during therapy with antiangiogenesis agents in patients with lung cancer. J Thorac Oncol; 2008 Apr;3(4):351-7
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  • [Title] Tumor cavitation during therapy with antiangiogenesis agents in patients with lung cancer.
  • Tumor cavitation is frequently noted in these patients, but the clinical significance of this finding has not been fully determined.
  • Our purposes were to evaluate the frequency, imaging characteristics, and clinical outcome of patients receiving antiangiogenesis agents who develop tumor cavitation, and correlate these findings with therapy related adverse events, especially hemoptysis.
  • Seventeen patients developed tumor cavitation during the trial (14%; median time to event, 1.8 months; range, 0.7-6.2 months), 16 patients (13%) had preexisting cavitary tumors, and 91 (73%) did not develop cavitation.
  • Cavity formation was more common with squamous cell histology (p = 0.04) but was not associated with hemoptysis (p = 0.12), tumor location (central versus peripheral), imaging characteristics, progression-free survival (p = 0.56), or overall survival (p = 0.33).
  • One of five patients with hemoptysis was fatal in a cavitary squamous cell tumor.
  • CONCLUSION: Development of tumor cavitation is not rare in lung cancer patients treated with antiangiogenesis agents, but the clinical implications are minimal in most cases.
  • [MeSH-major] Angiogenesis Inhibitors / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy
  • [MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / blood supply. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Adult. Aged. Aged, 80 and over. Carcinoma, Large Cell / blood supply. Carcinoma, Large Cell / drug therapy. Carcinoma, Large Cell / secondary. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / secondary. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate

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  • (PMID = 18379352.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors
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33. Hamadah I, Binamer Y, Alajlan S, Nassar A, Saleh AJ: Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation. Hematol Oncol Stem Cell Ther; 2010;3(2):84-8
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  • [Title] Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation.
  • Allogeneic hemopoietic stem cell transplantation (HSCT) has been considered a curative treatment option for many hematological and non-hematological disorders.
  • Despite the use of advanced methods of tissue typing and new therapies, graft versus host disease (GVHD) remains a major obstacle.
  • Secondary malignancies are also among the most serious long-term complications after HSCT including leukemia, lymphomas, and to a lesser extent, solid tumors.
  • The most commonly observed solid tumor is squamous cell carcinoma (SCC).
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Hematopoietic Stem Cell Transplantation. Lip Neoplasms / pathology. Lip Neoplasms / surgery. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery
  • [MeSH-minor] Adult. Graft vs Host Disease / pathology. Graft vs Host Disease / surgery. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Male. Multiple Myeloma / pathology. Multiple Myeloma / therapy. Transplantation, Homologous


34. Li XJ, Lin M, Liu CY, Xie HL: [Expression and clinical significance of EMS1 gene in gastric carcinoma]. Ai Zheng; 2008 Mar;27(3):323-6
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  • BACKGROUND & OBJECTIVE: EMS1 (chromosome eleven, band q13, mammary tumor and squamous cell carcinoma-associated gene 1) is correlated to the genesis, progression, invasion and metastasis of some malignancies.
  • METHODS: The expression of EMS1 protein in 20 specimens of normal gastric mucosa, 38 specimens of intraepithelial neoplasia, and 146 specimens of gastric carcinoma was detected by immunohistochemistry.
  • The positive rate of EMS1 protein was significantly higher in gastric carcinoma than in intraepithelial neoplasia and normal gastric mucosa (89.7% vs. 68.4% and 20.0%, P<0.001), and significantly higher in intraepithelial neoplasia than in normal gastric mucosa (P<0.001).
  • EMS1 protein expression had no correlations to sex, age, tumor differentiation and diameter.
  • [MeSH-major] Cortactin / genetics. Stomach Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 18334127.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / CTTN protein, human; 0 / Cortactin
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35. Kanner WA, Galgano MT, Atkins KA: Podoplanin expression in basal and myoepithelial cells: utility and potential pitfalls. Appl Immunohistochem Mol Morphol; 2010 May;18(3):226-30
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  • In addition, many salivary gland tumors and squamous cell carcinomas had strong D2-40 expression, sometimes making distinction of lymphatics versus tumor edge staining difficult.
  • D2-40 is excellent for assessing lymphatic invasion in breast, prostate, and cervix as long as the pathologist is aware of the expression in myoepithelial cells/basal cells to avoid misinterpretation of ductal carcinoma in situ or normal prostate glands or tumor stroma retraction as tumor lymphatic invasion.
  • Given the patchy positivity in basal cells of skin and mucosa and the reactivity in squamous cell carcinoma, D2-40 was not helpful in assessing for microinvasion of squamous cell carcinoma.

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  • (PMID = 20042851.001).
  • [ISSN] 1533-4058
  • [Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM
  • [ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
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36. McAllister KA, Houle CD, Malphurs J, Ward T, Collins NK, Gersch W, Wharey L, Seely JC, Betz L, Bennett LM, Wiseman RW, Davis BJ: Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation. Toxicol Pathol; 2006;34(2):187-98
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  • [Title] Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.
  • Mutations in both p53 and BRCA2 are commonly seen together in human tumors suggesting that the loss of both genes enhances tumor development.
  • We found decreased survival and timing of tumor onsets, and significantly higher overall tumor incidences and prevalence of particular tumors, including stomach tumors and squamous cell carcinomas, associated with the homozygous loss of Brca2, independent of p53 status.
  • The addition of a p53 mutation had a further impact on overall survival, incidence of osteosarcomas and stomach tumors, and tumor latency.
  • The spectrum of tumors observed for this Brca2 germline mouse model suggest that it faithfully recapitulates some human disease phenotypes associated with BRCA2 loss.
  • In addition, these findings include extensive in vivo data demonstrating that germline Brca2 and p53 mutations cooperatively affect animal survivals, tumor susceptibilities, and tumor onsets.
  • [MeSH-major] BRCA2 Protein / genetics. Genes, p53. Germ-Line Mutation. Neoplasms / genetics. Neoplasms, Radiation-Induced / genetics. Radiation, Ionizing
  • [MeSH-minor] Animals. Bone Neoplasms / genetics. Bone Neoplasms / physiopathology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / physiopathology. Female. Gene Expression Regulation, Neoplastic. Genetic Predisposition to Disease. Genotype. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Osteosarcoma / genetics. Osteosarcoma / physiopathology. Phenotype. Stomach Neoplasms / genetics. Stomach Neoplasms / physiopathology. Survival Rate. Time Factors


37. Tango Y, Kano R, Maruyama H, Asano K, Tanaka S, Hasegawa A, Kamata H: Detection of autoantibodies against survivin in sera from cancer dogs. J Vet Med Sci; 2010 Jul;72(7):917-20
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  • Survivin overexpression has been reported in relation to tumor malignancy, suggesting that it is an unfavorable prognostic marker, and antibody responses to this protein have been confirmed in human cancer patients.
  • The cut-off value for positivity in the anti-survivin ELISA was 0.35, as determined using the mean absorbance +2 S.D. of samples from healthy dogs.
  • Sera from 16 of 59 (27.1%) cancer and 3 of 25 (12%) non-cancer disease dogs were positive on ELISA.
  • The highest positivity rates (>50%) among the cancer cases were seen in dogs with mammary tumor, squamous cell carcinoma and melanoma.

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  • (PMID = 20179386.001).
  • [ISSN] 0916-7250
  • [Journal-full-title] The Journal of veterinary medical science
  • [ISO-abbreviation] J. Vet. Med. Sci.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Autoantibodies; 0 / DNA Primers; 0 / Microtubule-Associated Proteins
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38. Sahai A, Kodner IJ: Premalignant neoplasms and squamous cell carcinoma of the anal margin. Clin Colon Rectal Surg; 2006 May;19(2):88-93
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  • [Title] Premalignant neoplasms and squamous cell carcinoma of the anal margin.
  • Understanding anal anatomy and performing a biopsy of any suspicious lesions are essential in avoiding a delay in diagnosis and appropriately treating these tumors.
  • Combined multimodality treatment has come to play an important role in managing patient with more advanced or metastatic disease.

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  • (PMID = 20011315.001).
  • [ISSN] 1530-9681
  • [Journal-full-title] Clinics in colon and rectal surgery
  • [ISO-abbreviation] Clin Colon Rectal Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2780101
  • [Keywords] NOTNLM ; Anus neoplasms / Bowen's disease / Paget's disease / squamous cell cancer
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39. Plaza JA, Ortega PF, Bengana C, Stockman DL, Suster S: Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases. Am J Dermatopathol; 2010 Oct;32(7):683-7
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  • [Title] Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases.
  • When the morphologic distinction between basal cell carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two neoplasms from each other.
  • Their distinction is clinically important because the risk of progressive disease in BCC can be problematic, and trichoepitheliomas misinterpreted as BCC burdens the patient with an inaccurate diagnosis and consequential inappropriate surgery.
  • Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous neoplasms, such as adnexal tumors, squamous cell carcinomas, etc.
  • We studied the expression of D2-40 by immunohistochemistry to determine if this marker could reliably differentiate these neoplasms from each other.
  • A total of 49 cutaneous tumors, including 22 cases of trichoepitheliomas and 27 cases of BCC were examined.
  • This data suggests that D2-40 expression could be a useful potential marker to distinguish BCCs from trichoepitheliomas, especially when there is a high index of histologic suspicion for either of these two tumors.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Membrane Glycoproteins / biosynthesis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Antibodies, Monoclonal. Antibodies, Monoclonal, Murine-Derived. Diagnosis, Differential. Humans. Immunohistochemistry. Predictive Value of Tests

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  • (PMID = 20559122.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
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40. Fujishiro M, Yahagi N, Kakushima N, Kodashima S, Muraki Y, Ono S, Yamamichi N, Tateishi A, Shimizu Y, Oka M, Ogura K, Kawabe T, Ichinose M, Omata M: Endoscopic submucosal dissection of esophageal squamous cell neoplasms. Clin Gastroenterol Hepatol; 2006 Jun;4(6):688-94
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  • [Title] Endoscopic submucosal dissection of esophageal squamous cell neoplasms.
  • BACKGROUND & AIMS: Endoscopic submucosal dissection (ESD) has recently been developed for en bloc resection of stomach neoplasms, which results in high tumor eradication rates as well as a modality for the precise histologic assessment of the entire lesion.
  • Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus.
  • METHODS: An ESD with methods similar to those used for resections of early gastric cancer was performed on 58 consecutive esophageal SCNs with preoperative diagnoses of intraepithelial neoplasm or intramucosal invasive carcinoma occurring in 43 enrolled patients.
  • RESULTS: The rate of en bloc resection was 100% (58/58), and en bloc resection with tumor-free lateral/basal margins (R0 resection) was 78% (45/58).
  • Of 40 lesions occurring in 31 patients fulfilling the criteria of node-negative tumors (mean follow-up, 17 months), 1 lesion resected by en bloc resection with nonevaluable tumor-free lateral margins (Rx [lateral] resection) recurred locally 6 months after ESD, which was treated successfully by a second ESD procedure.
  • [MeSH-major] Esophageal Neoplasms / surgery. Esophagoscopy. Neoplasms, Squamous Cell / surgery

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  • (PMID = 16713746.001).
  • [ISSN] 1542-3565
  • [Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • [ISO-abbreviation] Clin. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 9679TC07X4 / Iodine
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41. Fallai C, Bolner A, Signor M, Gava A, Franchin G, Ponticelli P, Taino R, Rossi F, Ardizzoia A, Oggionni M, Crispino S, Olmi P: Long-term results of conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus concomitant radiotherapy and chemotherapy in locoregionally advanced carcinoma of the oropharynx. Tumori; 2006 Jan-Feb;92(1):41-54
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  • AIMS AND BACKGROUND: To compare conventional fractionation (CF) radiation therapy (RT), arm A, versus a split-course accelerated hyperfractionated schedule (S-AHF), arm B, versus CFRT plus concomitant chemotherapy (CT), arm C, in terms of five-year survival and toxicity for squamous cell tumors of the oropharynx.
  • Five-year second-tumor-free survival was 85%.
  • The 13 second tumors were equally distributed and were mainly correlated with tobacco and alcohol consumption (five lung, two esophagus, two oral cavity, one larynx, one pancreas, one hepatocarcinoma, one myeloma).
  • CONCLUSIONS: The results obtained with the combination of CT and RT compared with RT alone did not reach statistical significance, but combined treatment almost doubled the five-year overall survival, relapse-free survival and locoregional control rate.
  • Patients with advanced squamous cell carcinomas of the oropharynx who are medically suitable for the combined approach should be treated with a combination of radiotherapy and chemotherapy.
  • The occurrence of second tumors is relatively common in these patients and may contribute substantially to the causes of death.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Carboplatin / administration & dosage. Chemotherapy, Adjuvant / adverse effects. Dose Fractionation. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / drug therapy. Neoplasms, Second Primary / radiotherapy. Radiotherapy, Adjuvant / adverse effects. Radiotherapy, Adjuvant / methods. Risk Factors. Salvage Therapy. Survival Analysis. Time Factors. Treatment Failure. Treatment Outcome

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  • (PMID = 16683383.001).
  • [ISSN] 0300-8916
  • [Journal-full-title] Tumori
  • [ISO-abbreviation] Tumori
  • [Language] eng
  • [Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil
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42. Kluger N, Minier-Thoumin C, Plantier F: Keratoacanthoma occurring within the red dye of a tattoo. J Cutan Pathol; 2008 May;35(5):504-7
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  • Keratoacanthoma (KA) is a common keratinizing squamous cell neoplasm of unknown origin characterized by rapid growth and spontaneous involution.
  • Lack of papillomatosis and viral inclusions ruled out the diagnosis of viral wart, absence of granulomatous reaction ruled out deep fungal or mycobacterial infection and lack of cytological atypia and frank architectural abnormalities did not favour a squamous cell carcinoma.
  • Diagnosis can be challenging as differential diagnoses include pseudoepitheliomatous hyperplasia and squamous cell carcinoma.
  • [MeSH-minor] Adult. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Histiocytes / pathology. Humans. Keratinocytes / pathology. Keratins / analysis. Lymphocytes / pathology. Skin Neoplasms / diagnosis

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  • (PMID = 17976209.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents; 68238-35-7 / Keratins
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43. Shestakova T, Zhuravel E, Bolgova L, Alekseenko O, Soldatkina M, Pogrebnoy P: Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study. Exp Oncol; 2008 Jun;30(2):153-6
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  • [Title] Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study.
  • AIM: To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human lung tumors.
  • MATERIALS AND METHODS: Tissue samples of surgically resected human lung tumors (squamous cell carcinoma (SCC), n=10; adenocarcinoma (AC), n=10) paired with conditionally normal tissue samples were analyzed for expression of hBD-1, 2, 4 mRNA by semiquantitative RT-PCR.
  • No correlation was detected between the levels of hBD-1, hBD-2 and hBD-4 mRNA and histological type, differentiation grade of the tumor, and the stage of the disease, as well as the content of hBD-2 peptide in blood serum of lung cancer patients.
  • CONCLUSION: Human beta-defensins-1 and -2 are often up-regulated in human lung tumors.
  • [MeSH-major] Gene Expression Regulation, Neoplastic. Lung Neoplasms / metabolism. Up-Regulation. beta-Defensins / biosynthesis
  • [MeSH-minor] Cell Line, Tumor. Cohort Studies. Humans. Pilot Projects. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tissue Distribution

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  • (PMID = 18566581.001).
  • [ISSN] 1812-9269
  • [Journal-full-title] Experimental oncology
  • [ISO-abbreviation] Exp. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ukraine
  • [Chemical-registry-number] 0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / RNA, Messenger; 0 / beta-Defensins
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44. Jiang Y, Chen Y, Gao L, Ye Q, Alonso MA: [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 May;23(10):451-3
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  • [Title] [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx].
  • METHOD: Use the immunohistochemical technique to analyze the distribution of MAL in normal laryngeal epithelial cells, polyp of vocal cords, laryngeal atypical hyperplasia and laryngeal squamous cell carcinoma.
  • Comparatively, MAL expression is significantly down regulated in laryngeal atypical hyperplasia and laryngeal squamous cell carcinomas (P < 0.05).
  • MAL, therefore, is a potential marker for early diagnosis of laryngeal squamous cell carcinoma.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Laryngeal Mucosa / metabolism. Laryngeal Neoplasms / metabolism. Membrane Transport Proteins / metabolism. Myelin Proteins / metabolism. Proteolipids / metabolism

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  • (PMID = 19670627.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / MAL protein, human; 0 / Membrane Transport Proteins; 0 / Myelin Proteins; 0 / Myelin and Lymphocyte-Associated Proteolipid Proteins; 0 / Proteolipids
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45. Gualberto A, Dolled-Filhart M, Gustavson M, Christiansen J, Wang YF, Hixon ML, Reynolds J, McDonald S, Ang A, Rimm DL, Langer CJ, Blakely J, Garland L, Paz-Ares LG, Karp DD, Lee AV: Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition. Clin Cancer Res; 2010 Sep 15;16(18):4654-65
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  • [Title] Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition.
  • PURPOSE: This study aimed to identify molecular determinants of sensitivity of non-small cell lung cancer (NSCLC) to anti-insulin-like growth factor receptor (IGF-IR) therapy.
  • EXPERIMENTAL DESIGN: A total of 216 tumor samples were investigated, of which 165 consisted of retrospective analyses of banked tissue and an additional 51 were from patients enrolled in a phase II study of figitumumab, a monoclonal antibody against IGF-IR, in stage IIIb/IV NSCLC.
  • RESULTS: IGF-IR was differentially expressed across histologic subtypes (P = 0.04), with highest levels observed in squamous cell tumors.
  • Elevated IGF-IR expression was also observed in a small number of squamous cell tumors responding to chemotherapy combined with figitumumab (P = 0.008).
  • Furthermore, a higher response rate to the combination of chemotherapy and figitumumab was observed in transitional tumors (71%) compared with those in the mesenchymal-like subset (32%; P = 0.03).
  • Only one epithelial-like tumor was identified in the phase II study, suggesting that advanced NSCLC has undergone significant dedifferentiation at diagnosis.

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  • [Copyright] ©2010 AACR.
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  • (PMID = 20670944.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R01 ES015704-04; United States / NCI NIH HHS / CA / P50CA58183; United States / NIEHS NIH HHS / ES / R01 ES015704; United States / NIEHS NIH HHS / ES / ES015704; United States / NCI NIH HHS / CA / P50 CA058183; United States / NCI NIH HHS / CA / R01 CA094118
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Retracted Publication; Validation Studies
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Hormone Antagonists; 0 / Immunoglobulins, Intravenous; 67763-96-6 / Insulin-Like Growth Factor I; VE267FC2UB / figitumumab
  • [Other-IDs] NLM/ NIHMS226076; NLM/ PMC2952544
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46. Rodrigo JP, Cabanillas R, Chiara MD, García Pedrero J, Florentino Fresno M, Suárez Nieto C: [Molecular alterations in nodal metastases and its primary tumors in squamous cell carcinomas of the larynx]. Acta Otorrinolaringol Esp; 2008 Mar;59(3):114-9
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  • [Title] [Molecular alterations in nodal metastases and its primary tumors in squamous cell carcinomas of the larynx].
  • [Transliterated title] Alteraciones moleculares en las metástasis ganglionares y sus tumores primarios en los carcinomas epidermoides de laringe.
  • INTRODUCTION AND OBJECTIVES: The successive acquisition of molecular alterations determines tumour progression.
  • During this progression, the development of nodal metastases is one of the most important prognostic factors in laryngeal squamous cell carcinomas.
  • The aim of this study is to analyze if, in these carcinomas, the molecular alterations in the nodal metastases are different from those present in the primary tumour.
  • MATERIAL AND METHOD: Paired samples of primary tumour and nodal metastases from 51 patients with squamous cell carcinoma of the supraglottic larynx were studied.
  • RESULTS: A close correlation in the expression of the proteins studied was observed in the nodal metastases and the corresponding primary tumour, with the exception of HIF-1a expression and the degree of vascularization.
  • CONCLUSIONS: Most of the molecular alterations in the nodal metastases are already present in the primary tumour, suggesting that these alterations are early events in carcinogenesis.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Laryngeal Neoplasms / pathology
  • [MeSH-minor] Humans. Immunohistochemistry. Lymphatic Metastasis. Neoplasm Proteins / biosynthesis

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  • (PMID = 18364203.001).
  • [ISSN] 0001-6519
  • [Journal-full-title] Acta otorrinolaringológica española
  • [ISO-abbreviation] Acta Otorrinolaringol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Neoplasm Proteins
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47. Kitcher E, Yarney J, Gyasi R, Cheyuo C: Laryngeal cancer at the korle bu teaching hospital accra ghana. Ghana Med J; 2006 Jun;40(2):45-9
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  • The aim of this study was to determine the number of cases of laryngeal cancer seen at the Korle Bu Teaching Hospital, establish epidemiological parameters of the disease and to outline preventive measures.
  • METHOD: One hundred and fifteen (115) patients who were managed for laryngeal cancer from 1(st) January 1998 to 31(st) December 2003 were studied retrospectively with respect to age, sex, duration of symptoms at presentation, risk factors, symptoms complex, histopathology, stage of tumor, details of treatment offered and follow up.
  • A significant proportion of cases (37.3%) presented with locally advanced disease.
  • The commonest histological type of laryngeal tumour seen was squamous cell carcinoma.
  • Only 58 (69.9%) patients completed radiotherapy treatment and in all 32 (24.3 %) patients did not report for any treatment.
  • CONCLUSIONS: We conclude that significant number of patients with laryngeal cancer presented with locally advanced disease and dysphonia was the commonest symptom.

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  • (PMID = 17299565.001).
  • [ISSN] 0016-9560
  • [Journal-full-title] Ghana medical journal
  • [ISO-abbreviation] Ghana Med J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ghana
  • [Other-IDs] NLM/ PMC1790844
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48. Nishimura G, Horiuchi C, Yoshida T, Kawakami M, Yabuki K, Matsuda H, Mikami Y, Tsukuda M: Fibromatous polyp of the hypopharynx. Auris Nasus Larynx; 2006 Sep;33(3):333-6
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  • We treated a patient with hypopharyngeal fibromatous polyp and speculated the mechanism of this disease.
  • The greater part of hypopharyngeal tumors is squamous cell carcinomas, and benign tumors are really uncommon.
  • Fibromatous polyp is not thought to be a true tumor, but the symptoms are almost the same as tumorous diseases, e.g., discomfort in the throat, swallowing difficulty and respiratory distress.
  • [MeSH-major] Hypopharyngeal Neoplasms / diagnosis. Polyps / diagnosis

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  • (PMID = 16504437.001).
  • [ISSN] 0385-8146
  • [Journal-full-title] Auris, nasus, larynx
  • [ISO-abbreviation] Auris Nasus Larynx
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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49. Cai T, Nesi G, Boddi V, Mazzoli S, Dal Canto M, Bartoletti R: Prognostic role of the tumor-associated tissue inflammatory reaction in transitional bladder cell carcinoma. Oncol Rep; 2006 Aug;16(2):329-34
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  • [Title] Prognostic role of the tumor-associated tissue inflammatory reaction in transitional bladder cell carcinoma.
  • Many authors have indicated that the presence of an inflammatory response within the tumor may predict not only recurrence and progression but also survival in several tumors, including transitional cell carcinoma (TCC) of the urinary bladder.
  • The aim of the present study was to define the influence of inflammatory cell infiltrate on recurrence, progression and survival in TCC of the bladder over a long follow-up period.
  • Between January and December 1995, 410 consecutive patients, who had undergone transurethral or open surgery for bladder tumors at the same urologic center, were selected for the study.
  • All cases were reviewed to assess histotype, stage and grade of the tumor and presence or absence of tumor-associated inflammatory reaction.
  • Pathologic evaluation showed superficial TCC in 312 patients, while 98 had an invasive bladder tumor.
  • Three among 410 bladder tumors were squamous cell carcinomas.
  • Out of 407 TCCs, 119 (29.23%) presented inflammation within the tumor or the lamina propria.
  • At 10 years follow-up, a statistically significant association was shown between the presence of inflammation within the tumor or lamina propria and the number of recurrences (p<0.0001).
  • Moreover, the absence of inflammatory infiltrate in the tumor established the relative risk of suffering more than one recurrence at 2.287 (95% CI 1.180-3.346).
  • The Mann-Whitney test confirmed a statistically significant difference between superficial bladder tumors with inflammation and those without (26.3 vs 11.5 months, p<0.001).
  • On multivariate analysis, the presence of inflammation within the tumor was found to be an independent predictor of survival in patients with TCC of the bladder (p=0.027).
  • Survival analysis by means of the Kaplan-Meier curves showed a statistically significant difference between patients with tumor-associated inflammatory reaction and those without (p=0.0098).
  • These results confirm that the presence of inflammatory reaction has a good prognostic value in transitional bladder cell carcinoma.
  • However, to better define its prognostic significance, the characterization of inflammatory cells in tumor-associated tissue reaction must be accomplished.
  • [MeSH-major] Carcinoma, Transitional Cell / mortality. Carcinoma, Transitional Cell / pathology. Urinary Bladder Neoplasms / mortality. Urinary Bladder Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Inflammation / diagnosis. Inflammation / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis

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  • (PMID = 16820911.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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50. Au JT, Sugiyama G, Wang H, Nicastri A, Lee D, Ko W, Tak V: Carcinosarcoma of the oesophagus - a rare mixed type of tumor. J Surg Case Rep; 2010;2010(7):7
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  • [Title] Carcinosarcoma of the oesophagus - a rare mixed type of tumor.
  • Oesophageal carcinosarcoma is a rare type of oesophageal cancer composed of both squamous cells and sarcomatous cells.
  • On surgical pathology, it was discovered that the tumor had both squamous cell and sarcomatous cell components, and the final diagnosis was changed to oesophageal carcinosarcoma.

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  • [Copyright] © JSCR.
  • (PMID = 24946341.001).
  • [ISSN] 2042-8812
  • [Journal-full-title] Journal of surgical case reports
  • [ISO-abbreviation] J Surg Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3649142
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51. Wang L, Chang X, Yuan G, Zhao Y, Wang P: Expression of peptidylarginine deiminase type 4 in ovarian tumors. Int J Biol Sci; 2010;6(5):454-64
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  • [Title] Expression of peptidylarginine deiminase type 4 in ovarian tumors.
  • The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in SKOV-3 cells that originated from ovary tumors.
  • We utilized immunohistochemistry, real-time PCR and western blotting to analyze the expression of PADI4 in the tumor tissues and in the cell line that were cultured with estrodial-17β.
  • PADI4 was detected in serious cystadenocarcinoma (n=39, positivity=100%), clear cell cancer (n=7, positivity= 100%), mucinous cystadenocarcinoma (n=6, positivity=100%), dysgerminoma (n=6, positivity=100%), squamous cell tumor (n=6, positivity=100%), sibnet-ring cell carcinoma (n=6, positivity=100%), endodermal sinus tumor (n=6, positivity=100%), germ cell tumors (n=6, positivity=100%) and immature teratoma (n=6, positivity=100%).
  • However, PADI4 was either not detected or detected at low levels in granulosa cell tumor (n=6), malignant thecoma (n=6), ovarian cystadenoma (n=5) and normal ovarian tissue (n=11).
  • PADI4 was evenly distributed in the cytoplasm of tumor cells of serious cystadenocarcinoma that were classified as being grade II and III by histopathological scoring.
  • However, PADI4 showed granular cellular distribution in the tumor tissues that were isolated from grade I cystadenocarcinoma.
  • [MeSH-major] Hydrolases / metabolism. Ovarian Neoplasms / enzymology
  • [MeSH-minor] Blotting, Western. Cell Line, Tumor. Estradiol / pharmacology. Estradiol / physiology. Female. Gene Expression / drug effects. Humans. Immunohistochemistry. Polymerase Chain Reaction. RNA, Messenger / metabolism

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  • (PMID = 20827398.001).
  • [ISSN] 1449-2288
  • [Journal-full-title] International journal of biological sciences
  • [ISO-abbreviation] Int. J. Biol. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / RNA, Messenger; 4TI98Z838E / Estradiol; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase type IV
  • [Other-IDs] NLM/ PMC2935668
  • [Keywords] NOTNLM ; Peptidylarginine deiminase type 4 (PADI4/PAD4) / estrodial-17β. / ovarian cancer (OCa)
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52. Hainsworth JD, Fizazi K: Treatment for patients with unknown primary cancer and favorable prognostic factors. Semin Oncol; 2009 Feb;36(1):44-51
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  • Specific subsets include women with peritoneal carcinomatosis, women with isolated axillary lymph node metastases, adenocarcinoma presenting as a single metastatic lesion, young men with features of extragonadal germ cell tumor, squamous carcinoma involving cervical or inguinal lymph nodes, and neuroendocrine carcinoma.
  • [MeSH-major] Neoplasms, Unknown Primary / therapy
  • [MeSH-minor] Biomarkers, Tumor / analysis. Humans. Prognosis

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  • (PMID = 19179187.001).
  • [ISSN] 0093-7754
  • [Journal-full-title] Seminars in oncology
  • [ISO-abbreviation] Semin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 58
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53. Vilen ST, Nyberg P, Hukkanen M, Sutinen M, Ylipalosaari M, Bjartell A, Paju A, Haaparanta V, Stenman UH, Sorsa T, Salo T: Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. Exp Cell Res; 2008 Feb 15;314(4):914-26
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  • Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas.
  • We describe here that oral squamous cell carcinomas express all members of this cascade: MMP-9, trypsin-2 and enterokinase.
  • The expression of enterokinase in a carcinoma cell line not derived from the duodenum was shown here for the first time.
  • However, although both proteases were present also in various bone tumor tissues, MMP-9 and trypsin-2 never co-localized at the cellular level in these tissues.
  • This suggests that the intracellular vesicular co-localization, storage and possible activation of these proteases may be a unique feature for aggressive epithelial tumors, such as squamous cell carcinomas, but not for tumors of mesenchymal origin.
  • [MeSH-major] Carcinoma, Squamous Cell / enzymology. Enteropeptidase / metabolism. Matrix Metalloproteinase 9 / metabolism. Mouth Neoplasms / enzymology. Trypsin / metabolism. Trypsinogen / metabolism
  • [MeSH-minor] Bone Neoplasms / enzymology. Carcinoma / enzymology. Cell Line, Tumor. Enzyme Precursors / metabolism. Humans

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  • (PMID = 18062964.001).
  • [ISSN] 0014-4827
  • [Journal-full-title] Experimental cell research
  • [ISO-abbreviation] Exp. Cell Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Precursors; 103964-84-7 / PRSS2 protein, human; 9002-08-8 / Trypsinogen; EC 3.4.21.4 / Trypsin; EC 3.4.21.9 / Enteropeptidase; EC 3.4.24.- / pro-matrix metalloproteinase 9; EC 3.4.24.35 / Matrix Metalloproteinase 9
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54. Candelaria M, Arias-Bonfill D, Chávez-Blanco A, Chanona J, Cantú D, Pérez C, Dueñas-González A: Lack in efficacy for imatinib mesylate as second-line treatment of recurrent or metastatic cervical cancer expressing platelet-derived growth factor receptor alpha. Int J Gynecol Cancer; 2009 Dec;19(9):1632-7
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  • The median age was 49.8 years; all but 1 tumor were squamous cell carcinomas.
  • Ten (83.3%) had pelvic and systemic disease, whereas only 2 had systemic disease alone.
  • A single patient having metastatic disease in the lung showed stabilization for 6 months to then progressing in bone.
  • Despite lack of activity of single-agent imatinib, further studies in cervical cancer are deserved to better define the status of imatinib targets in this tumor and to investigate its activity in combination with cytotoxic drugs.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Uterine Cervical Neoplasms / drug therapy
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Benzamides. Chemotherapy, Adjuvant. Female. Humans. Imatinib Mesylate. Middle Aged. Neoplasm Metastasis. Recurrence. Survival Analysis. Treatment Outcome

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  • (PMID = 19955950.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
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55. Orrock JM, Abbott JJ, Gibson LE, Folpe AL: INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics. Am J Dermatopathol; 2009 Apr;31(2):152-6
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  • The morphological features of epithelioid sarcoma may closely mimic those of epithelial neoplasms, such as squamous cell carcinoma, mesenchymal tumors, such as benign fibrous histiocytoma, and nonneoplastic lesions, such as granuloma annulare.
  • Recently, loss of expression of INI1, a tumor suppressor gene/protein, and expression of GLUT-1, a glucose transporter protein, have been described in epithelioid sarcoma.
  • Twenty-four cases of epithelioid sarcoma, 13 cases of granuloma annulare, 10 cases of rheumatoid nodule, 19 cases of cutaneous squamous cell carcinoma, 7 cases of atypical fibroxanthoma, 9 cases of benign fibrous histiocytoma (dermatofibroma), and 3 cases of nodular fasciitis were immunostained for GLUT-1 and INI1 using commercially available antibodies, heat-induced epitope retrieval, and the Dako Envision detection system.
  • GLUT-1 was positive in 40%-50% of epithelioid sarcomas, all cases of granuloma annulare and rheumatoid nodules, 67% of benign fibrous histiocytomas, and in all squamous cell carcinomas.
  • In this clinical context, loss of INI1 expression seems to be an entirely specific marker of epithelioid sarcoma and this finding may be of great value in distinguishing CD34-negative epithelioid sarcoma from squamous cell carcinoma and in the distinction of rare cytokeratin-negative epithelioid sarcomas from necrobiotic processes, nodular fasciitis, and benign fibrous histiocytomas.
  • In contrast, there does not seem to be a role for GLUT-1 immunohistochemistry in this differential diagnosis.
  • [MeSH-major] Chromosomal Proteins, Non-Histone / metabolism. DNA-Binding Proteins / metabolism. Glucose Transporter Type 1 / metabolism. Granuloma Annulare / metabolism. Sarcoma / metabolism. Skin Diseases / metabolism. Skin Neoplasms / metabolism. Transcription Factors / metabolism
  • [MeSH-minor] Biomarkers / metabolism. Diagnosis, Differential. Fasciitis / metabolism. Fasciitis / pathology. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Humans. Neoplasms, Squamous Cell / metabolism. Neoplasms, Squamous Cell / pathology. Rheumatoid Nodule / metabolism. Rheumatoid Nodule / pathology. Xanthomatosis / metabolism. Xanthomatosis / pathology

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  • (PMID = 19318800.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Glucose Transporter Type 1; 0 / SMARCB1 protein, human; 0 / Transcription Factors
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56. Wyatt RM, Jones BJ, Dale RG: Radiotherapy treatment delays and their influence on tumour control achieved by various fractionation schedules. Br J Radiol; 2008 Jul;81(967):549-63
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  • [Title] Radiotherapy treatment delays and their influence on tumour control achieved by various fractionation schedules.
  • There is often a considerable delay from initial tumour diagnosis to the start of radiotherapy treatment.
  • This paper extends the calculations of a previous paper on the effects of delays before the initiation of radiotherapy treatment to include results from a variety of practical fractionation regimes for three different types of tumour: squamous cell carcinoma (head and neck), breast and prostate.
  • The linear quadratic model of radiation effect, logarithmic tumour growth (coupled with delay times where relevant) and the Poisson model for tumour control probability (TCP) are used to calculate the change in TCP for delays between diagnosis and treatment.
  • The results show that delays in the start of radiotherapy treatment do have an adverse effect on tumour control for fast-growing tumours.
  • For example, calculations predict a reduction in local tumour control of up to 1.5% per week's delay for head and neck cancers treated following surgery.
  • In addition, there may be a variety of fractionation regimes that will yield very similar clinical results for each tumour type.
  • It is shown theoretically that, for the tumour types considered here, it is possible to increase the dose per fraction and decrease the number of fractions while maintaining or increasing TCP relative to standard 2 Gy fractionation regimes, although there may be some advantage to using hyperfractionated regimes for head and neck cancers in order to reduce normal tissue effects.
  • [MeSH-major] Breast Neoplasms / radiotherapy. Head and Neck Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy


57. Hong JH, Yang YM, Kim HS, Lee SI, Muallem S, Shin DM: Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes. Prog Biophys Mol Biol; 2010 Sep;103(1):81-7
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  • [Title] Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes.
  • A mutation of Atp2a2 gene encoding the sarco/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) causes Darier's disease in human and null mutation in one copy of Atp2a2 leads to a high incidence of squamous cell tumor in a mouse model.
  • In SERCA2 heterozygote (SERCA2(+/-)) mice keratinocytes, mechanisms involved in partial depletion of SERCA2 gene and its related tumor induction have not been studied.
  • Using the gene fishing system, we first found in SERCA2(+/-) keratinocytes that gene level of tumor-associated calcium signal transducer 1, crystalline alphaB, procollagen XVIII alpha1, and nuclear factor I-B were increased.
  • These results suggest that the alterations of Ca(2+) signaling by SERCA2 haploinsufficiency alternate the gene expression of tumor induction and differentiation in keratinocytes.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Heterozygote. Keratinocytes / metabolism. Sarcoplasmic Reticulum Calcium-Transporting ATPases / genetics. Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism

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  • [Copyright] Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.
  • (PMID = 19840814.001).
  • [ISSN] 1873-1732
  • [Journal-full-title] Progress in biophysics and molecular biology
  • [ISO-abbreviation] Prog. Biophys. Mol. Biol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases
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58. Das M, Ansari KM, Dhawan A, Shukla Y, Khanna SK: Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice. Int J Cancer; 2005 Dec 10;117(5):709-17
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  • Single topical application of AO (0.15-0.3 ml) or isolated sanguinarine (4.5-18 micromol) followed by twice-weekly application of tetradecanoylphorbolmyristate acetate (TPA) for 25 weeks resulted in formation of tumors.
  • Histopathologically these tumors were of squamous cell carcinoma type and similar to those found in the positive control group using dimethylbenzanthracene (DMBA)/TPA.
  • Although the genotoxic lesions may be repaired to some extent on withdrawal of consumption of AO contaminated mustard oil and the residual genotoxic effects caused by AO may not be expressed as signs of carcinogenesis.

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc
  • (PMID = 15981203.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Alkaloids; 0 / Benzophenanthridines; 0 / Carcinogens; 0 / Isoquinolines; 0 / Plant Oils; 0 / argemone oil; AV9VK043SS / sanguinarine
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59. Kada S, Hirano S, Tateya I, Kitamura M, Ishikawa S, Kanda T, Asato R, Tanaka S, Ito J: Ten years single institutional experience of treatment for advanced laryngeal cancer in Kyoto University. Acta Otolaryngol Suppl; 2010 Nov;(563):68-73
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  • All tumors were squamous cell carcinoma, arising at the glottis in 21 cases and the supraglottis in 12 cases.
  • Five-year disease-specific survival rates for stage III of glottic cancer, stage IV of glottic cancer, stage III of supraglottic cancer, and stage IV of supraglottic cancer were 100%, 56.3%, 100%, and 28.1%, respectively.
  • Both of them died of disease despite undergoing chemotherapy.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / therapy

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  • (PMID = 20879822.001).
  • [ISSN] 0365-5237
  • [Journal-full-title] Acta oto-laryngologica. Supplementum
  • [ISO-abbreviation] Acta Otolaryngol Suppl
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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60. Abel EL, Angel JM, Kiguchi K, DiGiovanni J: Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat Protoc; 2009;4(9):1350-62
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  • For more than 60 years, the chemical induction of tumors in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors.
  • Subsequently, tumor development is elicited by repeated treatment with a tumor-promoting agent.
  • The initiation protocol can be completed within 1-3 h depending on the number of mice used; whereas the promotion phase requires twice weekly treatments (1-2 h) and once weekly tumor palpation (1-2 h) for the duration of the study.
  • Using the protocol described here, a highly reproducible papilloma burden is expected within 10-20 weeks with progression of a portion of the tumors to squamous cell carcinomas within 20-50 weeks.

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  • (PMID = 19713956.001).
  • [ISSN] 1750-2799
  • [Journal-full-title] Nature protocols
  • [ISO-abbreviation] Nat Protoc
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA076520; United States / NCI NIH HHS / CA / P30 CA016672; United States / NIEHS NIH HHS / ES / ES007784; United States / NCI NIH HHS / CA / R01 CA037111; United States / NCI NIH HHS / CA / CA016672; United States / NIEHS NIH HHS / ES / R01 ES016623; United States / NIEHS NIH HHS / ES / ES015718; United States / NIEHS NIH HHS / ES / P30 ES007784; United States / NIEHS NIH HHS / ES / R01 ES016623-02; United States / NIEHS NIH HHS / ES / ES016623; United States / NCI NIH HHS / CA / CA37111; United States / NCI NIH HHS / CA / R01 CA076520
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens
  • [Other-IDs] NLM/ NIHMS334643; NLM/ PMC3213400
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61. Clayton AC, Bentz JS, Wasserman PG, Schwartz MR, Souers RJ, Chmara BA, Laucirica R, Clary KM, Moriarty AT, College of American Pathologists Cytopathology Resource Committee: Comparison of ThinPrep preparations to other preparation types in gastrointestinal cytology: observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med; 2010 Aug;134(8):1116-20
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  • DESIGN: Participant responses between 2000 and 2007 were evaluated for esophageal wash/brush, gastric wash/brush, and biliary tract brush specimens with a reference diagnosis of adenocarcinoma, squamous cell carcinoma, carcinoid, or spindle cell neoplasm.
  • Overall performance of cytotechnologists was not different from that of pathologists (89.2% versus 89.0%; P = .75).
  • Cytotechnologists had better performance for detecting squamous cell carcinoma (96.3% versus 92.6%; P < .001), while pathologists had better performance for detecting spindle cell neoplasm (79.7% versus 42.9%; P < .001).
  • Cytotechnologists and pathologists performed at the same level overall, but with differences for the diagnosis of spindle cell neoplasm and squamous carcinoma.
  • [MeSH-major] Adenocarcinoma / diagnosis. Carcinoma, Squamous Cell / diagnosis. Gastrointestinal Neoplasms / diagnosis. Laboratories, Hospital / standards. Pathology, Clinical / methods

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  • (PMID = 20670130.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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62. Koike R, Nishimura Y, Nakamatsu K, Kanamori S, Shibata T: Concurrent chemoradiotherapy for esophageal cancer with malignant fistula. Int J Radiat Oncol Biol Phys; 2008 Apr 1;70(5):1418-22
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  • There were 9 patients with Stage III disease and 7 with Stage IV disease.
  • All tumors were squamous cell carcinomas.
  • [MeSH-major] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Esophageal Fistula / drug therapy. Esophageal Fistula / radiotherapy. Esophageal Neoplasms / drug therapy. Esophageal Neoplasms / radiotherapy

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  • (PMID = 18234437.001).
  • [ISSN] 0360-3016
  • [Journal-full-title] International journal of radiation oncology, biology, physics
  • [ISO-abbreviation] Int. J. Radiat. Oncol. Biol. Phys.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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63. Stewart DJ: Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. Crit Rev Oncol Hematol; 2010 Sep;75(3):173-234
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  • [Title] Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer.
  • While chemotherapy provides useful palliation, advanced lung cancer remains incurable since those tumors that are initially sensitive to therapy rapidly develop acquired resistance.
  • Resistance may arise from impaired drug delivery, extracellular factors, decreased drug uptake into tumor cells, increased drug efflux, drug inactivation by detoxifying factors, decreased drug activation or binding to target, altered target, increased damage repair, tolerance of damage, decreased proapoptotic factors, increased antiapoptotic factors, or altered cell cycling or transcription factors.
  • Factors for which there is now substantial clinical evidence of a link to small cell lung cancer (SCLC) resistance to chemotherapy include MRP (for platinum-based combination chemotherapy) and MDR1/P-gp (for non-platinum agents).
  • In non-small cell lung cancer (NSCLC), the strongest clinical evidence is for taxane resistance with elevated expression or mutation of class III beta-tubulin (and possibly alpha tubulin), platinum resistance and expression of ERCC1 or BCRP, gemcitabine resistance and RRM1 expression, and resistance to several agents and COX-2 expression (although COX-2 inhibitors have had minimal impact on drug efficacy clinically).
  • Tumors expressing high BRCA1 may have increased resistance to platinums but increased sensitivity to taxanes.
  • Limited early clinical data suggest that chemotherapy resistance in NSCLC may also be increased with decreased expression of cyclin B1 or of Eg5, or with increased expression of ICAM, matrilysin, osteopontin, DDH, survivin, PCDGF, caveolin-1, p21WAF1/CIP1, or 14-3-3sigma, and that IGF-1R inhibitors may increase efficacy of chemotherapy, particularly in squamous cell carcinomas.
  • Equivocal data (with some positive studies but other negative studies) suggest that NSCLC tumors with some EGFR mutations may have increased sensitivity to chemotherapy, while K-ras mutations and expression of GST-pi, RB or p27kip1 may possibly confer resistance.
  • To date, resistance-modulating strategies have generally not proven clinically useful in lung cancer, although small randomized trials suggest a modest benefit of verapamil and related agents in NSCLC.

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  • (PMID = 20047843.001).
  • [ISSN] 1879-0461
  • [Journal-full-title] Critical reviews in oncology/hematology
  • [ISO-abbreviation] Crit. Rev. Oncol. Hematol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA016672-32; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / 5-P30 CA16672-32; United States / NCI NIH HHS / CA / P30 CA016672-32
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Other-IDs] NLM/ NIHMS168520; NLM/ PMC2888634
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64. Razek AA: Diffusion-weighted magnetic resonance imaging of head and neck. J Comput Assist Tomogr; 2010 Nov-Dec;34(6):808-15
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  • Diffusion-weighted magnetic resonance imaging plays a role in the differentiation of benign from malignant head and neck tumors, squamous cell carcinoma from lymphoma, and metastatic from benign lymphadenopathy as well as in the selection of the biopsy site.
  • It can be used for the differentiation of recurrent tumors from posttreatment changes and in monitoring the patient after radiotherapy.
  • It helps in the differentiation of necrotic tumors from abscesses.
  • [MeSH-major] Diffusion Magnetic Resonance Imaging / methods. Head and Neck Neoplasms / diagnosis
  • [MeSH-minor] Biopsy. Diagnosis, Differential. Echo-Planar Imaging. Humans. Image Enhancement / methods. Lymphatic Metastasis. Neoplasm Recurrence, Local / diagnosis. Neoplasm Staging

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  • (PMID = 21084893.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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65. National Toxicology Program: Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study). Natl Toxicol Program Tech Rep Ser; 2010 Sep;(553):7-33, 35-97, 99-103 passim
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  • Mice that received no cream treatment and were exposed to increasing levels of SSL showed significant SSL exposure-dependent decreases in survival and significant increases in the in-life observations of skin lesion onset, incidence, and multiplicity, and significant SSL exposure-dependent increases in the incidences and multiplicities of histopathology-determined squamous cell nonneoplastic skin lesions (squamous hyperplasia and focal atypical hyperplasia) and squamous cell neoplasms (papilloma, carcinoma in situ, and/or carcinoma).
  • Squamous cell neoplasms were not detected in mice that received no SSL exposure.
  • The topical treatment with the control cream of mice that were exposed to SSL did not impart a measurable effect when compared with comparable measurements in mice that received no cream treatment and were exposed to the same level of SSL, suggesting that the control cream used in these studies did not alter the efficiency of the SSL delivered to mice or the tolerability of mice to SSL.
  • The administration of aloe gel creams to male mice had no effect on the incidences or multiplicities of histopathology-determined squamous cell nonneoplastic skin lesions or neoplasms.
  • Female mice treated with aloe gel creams (3% and 6%) had significantly increased multiplicities of squamous cell neoplasms.
  • In male mice exposed to SSL and treated with the 6% whole leaf cream, a significant increase was observed in the multiplicity of squamous cell neoplasms.
  • Female mice exposed to SSL and treated with the 3% whole leaf creams had significantly decreased multiplicity of squamous cell nonneoplastic lesions and significantly increased multiplicity of squamous cell neoplasms.
  • Female mice exposed to SSL and treated with the 6% whole leaf cream had significantly decreased multiplicity of squamous cell nonneoplastic lesions.
  • Male mice administered the 3% decolorized whole leaf cream had significantly increased multiplicity of squamous cell neoplasms.
  • Female mice administered the 3% decolorized whole leaf cream had significantly decreased multiplicity of squamous cell nonneoplastic skin lesions and significantly increased multiplicity of squamous cell neoplasms.
  • In female mice that received the 6% decolorized whole leaf cream, there was a significant increase in the multiplicity of squamous cell neoplasms.
  • The administration of aloe-emodin creams to male mice had no effect on the incidence or multiplicity of histopathology-determined nonneoplastic skin lesions or squamous cell neoplasms.
  • Female mice treated with the 74.6 µg/g aloe-emodin cream had significantly decreased multiplicity of histopathology-determined squamous cell nonneoplastic skin lesions and significantly increased multiplicity of squamous cell neoplasms.
  • ALOE GEL OR ALOE-EMODIN: under the conditions of these studies, there was a weak enhancing effect of aloe gel or aloe-emodin on the photocarcinogenic activity of SSL in female but not in male SKH-1 mice based on an increase in the multiplicity of histopathologically-determined squamous cell neoplasms.
  • ALOE WHOLE LEAF OR DECOLORIZED WHOLE LEAF: under the conditions of these studies, there was a weak enhancing effect of aloe whole leaf or decolorized whole leaf on the photocarcinogenic activity of SSL in both male and female SKH-1 mice based on an increase in the multiplicity of histopathologically-determined squamous cell neoplasms.
  • [MeSH-major] Aloe / toxicity. Plant Extracts / toxicity. Skin Neoplasms / etiology. Sunlight / adverse effects

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  • (PMID = 21031007.001).
  • [ISSN] 0888-8051
  • [Journal-full-title] National Toxicology Program technical report series
  • [ISO-abbreviation] Natl Toxicol Program Tech Rep Ser
  • [Language] eng
  • [Publication-type] Journal Article; Technical Report
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts
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66. Srivastava A, Ghosh A, Saha S, Saha VP, Chakraborty D: Sarcomas of head and neck - A 10 yrs experience. Indian J Otolaryngol Head Neck Surg; 2007 Dec;59(4):322-6
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  • Compared to other types of head and neck neoplasms, such as squamous cell carcinoma, soft tissue sarcomas have low rates of regional metastases.
  • Surgery generally has been recommended as the primary method of treatment for achieving local control, except in those high-grade tumours arising in sites not amenable to resection.

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  • (PMID = 23120465.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3452262
  • [Keywords] NOTNLM ; CT Scan / Chemoradiation / Excisional Biopsy / Prognostic factors / Soft tissue sarcoma / Survival rate
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67. Greenberger JS, Epperly MW: Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization. In Vivo; 2007 Mar-Apr;21(2):141-6
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  • [Title] Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization.
  • In experiments to determine whether organ-specific radioprotection would also protect orthotopic tumors, mice with Lewis lung carcinoma orthotopically placed at the carina or in other experiments with mice with cheek pouch placed SCCVII orthotopic squamous cell tumors demonstrated paradoxical and beneficial tumor radiosensitization following intratracheal or intraoral MnSOD-PL, respectively.
  • The mechanism of MnSOD-PL tumor radiosensitization may involve a difference in redox balance between tumors and normal tissues.
  • Differences in handling radiation-induced oxidative stress between tumors and normal tissues can provide a fundamental basis to design new cancer therapeutic agents which can exploit differences between normal tissue and tumor mechanisms of handling the oxidative stress of ionizing irradiation damage.
  • [MeSH-major] Antioxidants / therapeutic use. Neoplasms / radiotherapy. Radiation-Protective Agents / therapeutic use
  • [MeSH-minor] Animals. Genetic Therapy / methods. Humans. Lung Neoplasms / radiotherapy. Mice

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  • (PMID = 17436562.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / 1-R01-CA101837-01
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Antioxidants; 0 / Radiation-Protective Agents
  • [Number-of-references] 73
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68. Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo AA, Ji Y, Leapman RD, Gutkind JS, Rusling JF: Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond); 2010 Dec;5(10):1535-46
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  • Efficacy of PEG-SWCNT-cisplatin for tumor growth inhibition was studied in mice.
  • RESULTS & DISCUSSION: PEG-SWCNTs were efficiently dispersed in aqueous media compared with controls, and did not induce apoptosis in vitro.
  • PEG-SWCNT-cisplatin with the attached targeting ligand EGF successfully inhibited growth of head and neck tumor xenografts in mice.
  • CONCLUSIONS: PEG-SWCNTs, as opposed to control SWCNTs, form more highly dispersed delivery vehicles that, when loaded with both cisplatin and EGF, inhibit growth of squamous cell tumors.

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  • (PMID = 21143032.001).
  • [ISSN] 1748-6963
  • [Journal-full-title] Nanomedicine (London, England)
  • [ISO-abbreviation] Nanomedicine (Lond)
  • [Language] ENG
  • [Grant] United States / NIEHS NIH HHS / ES / R01 ES013557; United States / NIEHS NIH HHS / ES / R01 ES013557-05; United States / NIEHS NIH HHS / ES / ES013557; United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Nanotubes, Carbon; 30IQX730WE / Polyethylene Glycols
  • [Other-IDs] NLM/ NIHMS323825; NLM/ PMC3175610
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69. Oki-Idouchi CE, Lorenzo PS: Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin. Cancer Res; 2007 Jan 1;67(1):276-80
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  • [Title] Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin.
  • We have recently shown expression of RasGRP1 in the epidermal keratinocytes where it can mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a well-known mouse skin tumor promoter.
  • However, a percentage of the adult transgenic population developed spontaneous skin tumors, mainly squamous cell papillomas.
  • The transgene was detected in the tumors as well as in primary keratinocytes isolated from transgenic mice.
  • We noticed a correlation between tumor incidence and wounding, which suggests that RasGRP1 overexpression may confer sensitivity to promotional stimuli, like wound repair mechanisms.

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  • (PMID = 17210708.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA096841; United States / NCI NIH HHS / CA / 1R01 CA 096841; United States / NCI NIH HHS / CA / R01 CA096841-04
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Guanine Nucleotide Exchange Factors; 0 / Rasgrp1 protein, mouse
  • [Other-IDs] NLM/ NIHMS19989; NLM/ PMC1885541
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70. Créhange G, Bosset M, Lorchel F, Buffet-Miny J, Dumas JL, Mercier M, Puyraveau M, Maingon P, Bosset JF: Tumor volume as outcome determinant in patients treated with chemoradiation for locally advanced esophageal cancer. Am J Clin Oncol; 2006 Dec;29(6):583-7
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  • [Title] Tumor volume as outcome determinant in patients treated with chemoradiation for locally advanced esophageal cancer.
  • OBJECTIVE: The currently used tumor-node metastasis (TNM) staging method is generally not applicable to patients with unresectable esophageal carcinomas.
  • There is a need for both an efficient, easy-to-perform clinical classification and for identification of pretherapeutic prognostic factors that would be useful for oncologists, one of which is tumor volume.
  • Using the computed tomography (CT) scan classification, tumors were recorded as follows: 1 T1, 42 T2, 93 T3, 6 T4, 2 Nx, 72 N0, 74 N1.
  • Tumor volume from the CT scans was determined as the sum of 2 opposed truncated cones.
  • Median tumor volume was 57.5 cm3 (range, 0.6-288 cm3).
  • Prognostic factors identified by univariate analysis were: dysphagia grade > or =2, other histology than squamous cell, tumor location below the carina, age <65 years and tumor volume > or =100 cm3.
  • Prognostic factors identified with multivariate analysis were: dysphagia grade > or =2 (P = 0.013), weight loss > or =10% (P = 0.047), tumor location below the carina (P = 0.002), and tumor volume > or =100 cm3 (P = 0.041).
  • CONCLUSIONS: For patients that the TNM staging system is not applicable, tumor volume is a new powerful determinant of survival.
  • [MeSH-major] Esophageal Neoplasms / pathology. Neoplasm Staging / methods


71. Dessolle L, Dalmon C, Roche B, Menain N, Daraï E: Placental metastases from a maternal squamous cell tumor of the maxillary. Eur J Obstet Gynecol Reprod Biol; 2005 Nov 1;123(1):117-8
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  • [Title] Placental metastases from a maternal squamous cell tumor of the maxillary.
  • [MeSH-major] Maxillary Neoplasms / pathology. Neoplasms, Squamous Cell / pathology. Placenta / pathology
  • [MeSH-minor] Adult. Cesarean Section. Female. Humans. Infant, Newborn. Maxillary Sinus Neoplasms / drug therapy. Maxillary Sinus Neoplasms / pathology. Maxillary Sinus Neoplasms / radiotherapy. Neoplasm Metastasis. Pregnancy. Pregnancy Complications, Neoplastic / etiology

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  • (PMID = 16225980.001).
  • [ISSN] 0301-2115
  • [Journal-full-title] European journal of obstetrics, gynecology, and reproductive biology
  • [ISO-abbreviation] Eur. J. Obstet. Gynecol. Reprod. Biol.
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Ireland
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72. Pagaki E, Patsouris E, Gonidi M, Athanassiadou AM, Maurikakis M, Athanassiades P, Chelidonis G, Athanassiadou P: The value of E-cadherin/beta-catenin expression in imprints of NCSLC: relationship with clinicopathological factors. Diagn Cytopathol; 2010 Jun;38(6):419-24
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  • [Title] The value of E-cadherin/beta-catenin expression in imprints of NCSLC: relationship with clinicopathological factors.
  • Metastasis is specific for malignant tumors and its control is one of the most important problems in the design of therapies for cancer patients.
  • Loss or reduction of E-cadherin expression and/or beta-catenin expression plays a casual role in tumor progression and metastasis and is associated with poor prognosis.
  • The purpose of the study is to investigate the expression of E-cadherin and beta-catenin and their significance as independent prognostic markers in imprints of resected nonsmall cell lung cancer (NSCLC).
  • Histologically 47 (67.1%) of the tumors were squamous cell carcinomas and 23 (32.9%) were adenocarcinomas.
  • Tumors stage was I in 29 (41.4%), II in 13 (18.6%), III in 24 (34.3%) and IV in 4 (5.7%).
  • Positive expression of E-cadherin and beta-catenin was observed in moderate and well differentiated tumors (P < 0.0001 for both respectively).
  • There was no statistically significant association between histological type, tumor stage, pleural invasion, tumor size (P > 0.05 for all) and E-cadherin/beta-catenin expression.Reduced E-cadherin or beta-catenin negative expression relates to dedifferentiation and progression of NSCLC.
  • [MeSH-major] Cadherins / biosynthesis. Carcinoma, Non-Small-Cell Lung / metabolism. Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / metabolism. Lung Neoplasms / pathology. beta Catenin / biosynthesis
  • [MeSH-minor] Aged. Biomarkers, Tumor / analysis. Humans. Immunohistochemistry. Middle Aged. Neoplasm Staging. Prognosis

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  • [Copyright] (c) 2010 Wiley-Liss, Inc.
  • (PMID = 20474081.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cadherins; 0 / beta Catenin
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73. El Khatib K, Danino A, Trost O, Jidal B, Malka G: [Use of nasolabial flap for mouth floor reconstruction]. Ann Chir Plast Esthet; 2005 Jun;50(3):216-20
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  • SUBJECT: Oral cavity cancers represent 30% of the cephalic extremity tumors.
  • The patients benefited from a surgical resection of the tumor by respecting the safety margins, with an immediate reconstruction allowing the restoring of the oral functions.
  • The majority of tumors were squamous cell carcinomas (50 cases).
  • As complications, we noted one complete necrosis and two partial necrosis of the flap, two postoperative wound complications with dehiscence as well as a massive local recurrence of initial tumor in one patient.
  • [MeSH-major] Mouth Neoplasms / surgery. Neoplasm Recurrence, Local. Postoperative Complications. Reconstructive Surgical Procedures / methods. Surgical Flaps

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  • (PMID = 15896896.001).
  • [ISSN] 0294-1260
  • [Journal-full-title] Annales de chirurgie plastique et esthétique
  • [ISO-abbreviation] Ann Chir Plast Esthet
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] France
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74. Castillo A, Aguayo F, Koriyama C, Shuyama K, Akiba S, Herrera-Goepfert R, Carrascal E, Klinge G, Sánchez J, Eizuru Y: Human papillomavirus in lung carcinomas among three Latin American countries. Oncol Rep; 2006 Apr;15(4):883-8
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  • We examined HPV genome in 36 lung carcinomas, consisting of 14 squamous cell carcinomas, 13 adenocarcinomas, and 9 small cell carcinomas, collected from Colombia, Mexico and Peru.
  • This percentage is similar to the value of 22% reported by Syrjänen, who conducted a meta-analysis of nearly 2500 lung carcinomas examined to date.
  • HPV-16 was more frequently found among female than male cases (P=0.008) but was not detected in any adenocarcinoma cases.
  • The presence of HPV tended to be more frequent in well-differentiated tumors when squamous cell carcinomas and adenocarcinomas were combined.
  • However, it was not statistically significant (P=0.093).
  • [MeSH-major] Lung Neoplasms / virology. Papillomaviridae / genetics. Papillomavirus Infections / virology
  • [MeSH-minor] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / virology. Aged. Blotting, Southern. Carcinoma, Small Cell / metabolism. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / virology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Colombia. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA, Viral / chemistry. DNA, Viral / genetics. DNA, Viral / isolation & purification. Female. Genome, Viral. Genotype. Human papillomavirus 16 / genetics. Human papillomavirus 18 / genetics. Humans. Immunohistochemistry. Male. Mexico. Middle Aged. Peru. Sequence Analysis, DNA. Sex Factors. Tumor Suppressor Protein p53 / analysis

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  • (PMID = 16525675.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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75. Doi AM, Hailey JR, Hejtmancik M, Toft JD 2nd, Vallant M, Chhabra RS: Topical application of representative multifunctional acrylates produced proliferative and inflammatory lesions in F344/N rats and B6C3F1 mice, and squamous cell neoplasms in Tg.AC mice. Toxicol Pathol; 2005;33(6):631-40
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  • [Title] Topical application of representative multifunctional acrylates produced proliferative and inflammatory lesions in F344/N rats and B6C3F1 mice, and squamous cell neoplasms in Tg.AC mice.
  • Topical application of TMPTA and PETA to Tg.AC mice showed dose-dependent increases in squamous cell papillomas at the site of application, with decreases in the latency of their appearance in mice receiving 3 mg/kg or greater.
  • Papillomas, the reporter phenotype in Tg.AC mice, were accompanied by a few squamous cell carcinomas, along with hyperplastic and inflammatory lesions.
  • [MeSH-major] Acrylates / toxicity. Papilloma / chemically induced. Precancerous Conditions / chemically induced. Propylene Glycols / toxicity. Skin Neoplasms / chemically induced. Stomach Neoplasms / chemically induced


76. Gevaert O, Daemen A, De Moor B, Libbrecht L: A taxonomy of epithelial human cancer and their metastases. BMC Med Genomics; 2009;2:69
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  • Additionally, it has not yet been extensively investigated whether metastases resemble their tissue of origin or tissue of destination.
  • Chromophobe renal cell carcinoma clustered together with follicular differentiated thyroid carcinoma, which supports recent morphological descriptions of thyroid follicular carcinoma-like tumors in the kidney and suggests that they represent a subtype of chromophobe carcinoma.
  • We also found an expression signature identifying primary tumors of squamous cell histology in multiple tissues.
  • Next, a subset of ovarian tumors enriched with endometrioid histology clustered together with endometrium tumors, confirming that they share their etiopathogenesis, which strongly differs from serous ovarian tumors.
  • In addition, the clustering of colon and breast tumors correlated with clinico-pathological characteristics.
  • Moreover, a signature was developed based on our unsupervised clustering of breast tumors and this was predictive for disease-specific survival in three independent studies.
  • A significant part clusters with tissue of origin while the remaining tumors cluster with the tissue of destination.
  • [MeSH-major] Neoplasm Metastasis. Neoplasms, Glandular and Epithelial / classification. Neoplasms, Glandular and Epithelial / pathology. Systems Biology
  • [MeSH-minor] Cluster Analysis. Gene Expression Profiling. Genomics. Humans. Internationality. Neoplasms, Unknown Primary / therapy. Oligonucleotide Array Sequence Analysis

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  • (PMID = 20017941.001).
  • [ISSN] 1755-8794
  • [Journal-full-title] BMC medical genomics
  • [ISO-abbreviation] BMC Med Genomics
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2806369
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77. Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C: Activator protein-1 activity regulates epithelial tumor cell identity. Cancer Res; 2006 Aug 1;66(15):7578-88
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  • [Title] Activator protein-1 activity regulates epithelial tumor cell identity.
  • When A-FOS was expressed during chemical-induced skin carcinogenesis, mice do not develop characteristic benign and malignant squamous lesions but instead develop benign sebaceous adenomas containing a signature mutation in the H-ras proto-oncogene.
  • Inhibiting AP-1 activity after tumor formation caused squamous tumors to transdifferentiate into sebaceous tumors.
  • Furthermore, reactivating AP-1 in sebaceous tumors results in a reciprocal transdifferentiation into squamous tumors.
  • In both cases of transdifferentiation, individual cells express molecular markers for both cell types, indicating individual tumor cells have the capacity to express multiple lineages.
  • Molecular characterization of cultured keratinocytes and tumor material indicates that AP-1 regulates the balance between the wnt/beta-catenin and hedgehog signaling pathways that determine squamous and sebaceous lineages, respectively.
  • Thus, AP-1 activity regulates tumor cell lineage and is essential to maintain the squamous tumor cell identity.
  • [MeSH-major] Adenocarcinoma, Sebaceous / metabolism. Carcinoma, Squamous Cell / metabolism. Skin Neoplasms / metabolism. Transcription Factor AP-1 / metabolism
  • [MeSH-minor] Animals. DNA, Neoplasm / metabolism. Hyperplasia. Keratinocytes / metabolism. Mice. Mice, Transgenic. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Promoter Regions, Genetic. Protein Binding. Proto-Oncogene Proteins c-fos / biosynthesis. Proto-Oncogene Proteins c-fos / genetics. Proto-Oncogene Proteins c-jun / metabolism. Sebaceous Glands / pathology. Transcriptional Activation. Wnt Proteins / genetics


78. Paruchuri V, Prasad A, McHugh K, Bhat HK, Polyak K, Ganju RK: S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation. PLoS One; 2008 Mar 05;3(3):e1741
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  • S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in squamous cell tumors of the skin, lung and breast.
  • Although its expression has been correlated to HER+ high-grade tumors and to a high risk of progression, the molecular mechanisms of these S100A7-mediated tumorigenic effects are not well known.
  • Here, we showed for the first time that epidermal growth factor (EGF) induces S100A7 expression in both MCF-7 and MDA-MB-468 cell lines.
  • We also observed a decrease in EGF-directed migration in shRNA-downregulated MDA-MB-468 cell lines.
  • Furthermore, our signaling studies revealed that EGF induced simultaneous EGF receptor phosphorylation at Tyr1173 and HER2 phosphorylation at Tyr1248 in S100A7-downregulated cell lines as compared to the vector-transfected controls.
  • In addition, reduced phosphorylation of Src at tyrosine 416 and p-SHP2 at tyrosine 542 was observed in these downregulated cell lines.
  • Our results also showed decreased tumor-induced osteoclastic resorption in an intra-tibial bone injection model involving SCID mice.
  • S100A7-downregulated cells had decreased osteoclast number and size as compared to the vector controls, and this decrease was associated with variations in IL-8 expression in in vitro cell cultures.

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  • (PMID = 18320059.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA109527; United States / NCI NIH HHS / CA / CA109527
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Drug Combinations; 0 / Interleukin-8; 0 / Laminin; 0 / Proteoglycans; 0 / S100 Proteins; 0 / S100A7 protein, human; 0 / S100A7 protein, mouse; 119978-18-6 / matrigel; 42HK56048U / Tyrosine; 62229-50-9 / Epidermal Growth Factor; 9007-34-5 / Collagen; EC 2.7.10.1 / Erbb2 protein, mouse; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
  • [Other-IDs] NLM/ PMC2254193
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79. Subhashraj K, Orafi M, Nair KV, El-Gehani R, Elarbi M: Primary malignant tumors of orofacial region at Benghazi, Libya: a 17 years review. Cancer Epidemiol; 2009 Nov;33(5):332-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary malignant tumors of orofacial region at Benghazi, Libya: a 17 years review.
  • The aim of this study was to systematically analyze the clinical presentations of orofacial malignant tumors in a Libyan population over a period of 17 years and compare the results with the reports from other countries.
  • During the study period, tumors of epithelial origin were found in 160 patients (82%), followed by tumors of immune system, 22 (11%) and tumors of mesenchymal origin, 14 (7%).
  • Of the total malignant tumors, 115 were men and 81 were women and the male to female ratio was 1.41:1.
  • Malignant non-odontogenic tumors were seen in 194 patients (99%) and malignant odontogenic tumors were seen in 2 patients (1%).
  • Among the epithelial tumors, squamous cell carcinoma (50.6%) was the most common neoplasm, followed by mucoepidermoid carcinoma (15%) and adenoid cystic carcinoma (8.7%).
  • [MeSH-major] Facial Neoplasms / epidemiology. Facial Neoplasms / pathology. Mouth Neoplasms / epidemiology. Mouth Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Oral Cancer.
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  • (PMID = 19932650.001).
  • [ISSN] 1877-783X
  • [Journal-full-title] Cancer epidemiology
  • [ISO-abbreviation] Cancer Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Netherlands
  • [Number-of-references] 35
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80. Domínguez-Cherit J, Chanussot-Deprez C, Maria-Sarti H, Fonte-Avalos V, Vega-Memije E, Luis-Montoya P: Nail unit tumors: a study of 234 patients in the dermatology department of the "Dr Manuel Gea González" General Hospital in Mexico City. Dermatol Surg; 2008 Oct;34(10):1363-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Nail unit tumors: a study of 234 patients in the dermatology department of the "Dr Manuel Gea González" General Hospital in Mexico City.
  • BACKGROUND: The frequency of nail unit tumors is not well known because they are often misdiagnosed, and the clinical appearance of benign and malignant tumors is not characteristic.
  • RESULTS: The tumors most frequently diagnosed were fibrous tumors (29.05%), osteocartilaginous tumors (21.79%), and myxoid pseudocysts (11.96%).
  • Malignant melanoma occupied the fourth place (9.82%), and the second most frequent malignant tumor was squamous cell carcinoma (SCC; 4.70%).
  • Among other tumors were glomus, neurofibromas, giant cell tumors of tendon sheath, and pyogenic granulomas.
  • CONCLUSION: This study in a Mexican population sheds light on the frequency and the alterations produced by nail unit tumors, which we must keep in mind for a more accurate diagnosis.
  • [MeSH-major] Nail Diseases / diagnosis. Skin Neoplasms / diagnosis