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1
805 808 squamous cell neoplasms 2005:2010[pubdate] *count=100
174 results
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Items 1 to 100 of about 174
6.
Mopuri N, Laitung JK, Cardozo C:
Collision tumour of squamous cell carcinoma and invasive malignant melanoma of scalp - a case report.
J Plast Reconstr Aesthet Surg
; 2009 May;62(5):e104-5
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[Source]
The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
[Title]
Collision
tumour
of
squamous cell
carcinoma and invasive malignant melanoma of scalp - a case report.
[MeSH-major]
Carcinoma,
Squamous Cell
/ pathology. Head and Neck
Neoplasms
/ pathology. Melanoma / pathology.
Neoplasms
, Multiple Primary / pathology. Scalp. Skin
Neoplasms
/ pathology
[MeSH-minor]
Aged, 80 and over. Humans. Male.
Neoplasm
Invasiveness
Genetic Alliance.
consumer health - Carcinoma, Squamous Cell
.
MedlinePlus Health Information.
consumer health - Head and Neck Cancer
.
MedlinePlus Health Information.
consumer health - Melanoma
.
MedlinePlus Health Information.
consumer health - Skin Cancer
.
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(PMID = 19064339.001).
[ISSN]
1878-0539
[Journal-full-title]
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
[ISO-abbreviation]
J Plast Reconstr Aesthet Surg
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
Netherlands
7.
Pfeifer GP, Rauch TA:
DNA methylation patterns in lung carcinomas.
Semin Cancer Biol
; 2009 Jun;19(3):181-7
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The genome of epithelial
tumors
is characterized by numerous chromosomal aberrations, DNA base sequence changes, and epigenetic abnormalities.
In
squamous cell
carcinomas of the lung, CpG methylation patterns undergo substantial changes relative to normal lung epithelium.
Interestingly, a large fraction (almost 80%) of the
tumor
-specifically methylated sequences are targets of the Polycomb complex in embryonic stem cells.
Homeobox genes are particularly overrepresented and all four HOX gene loci on chromosomes 2, 7, 12, and 17 are hotspots for
tumor
-associated methylation because of the presence of multiple methylated CpG islands within these loci.
DNA hypomethylation at CpGs in
squamous cell
tumors
preferentially affects repetitive sequence classes including SINEs, LINEs, subtelomeric repeats, and segmental duplications.
Since these epigenetic changes are found in early stage
tumors
, their contribution to
tumor
etiology as well as their potential usefulness as diagnostic or prognostic biomarkers of the
disease
should be considered.
MedlinePlus Health Information.
consumer health - Lung Cancer
.
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(PMID = 19429482.001).
[ISSN]
1096-3650
[Journal-full-title]
Seminars in cancer biology
[ISO-abbreviation]
Semin. Cancer Biol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA084469; None / None / / R21 CA128495-02; United States / NCI NIH HHS / CA / CA084469; United States / NCI NIH HHS / CA / R01 CA084469-09; United States / NCI NIH HHS / CA / CA128495; None / None / / R01 CA084469-09; United States / NCI NIH HHS / CA / R21 CA128495-02; United States / NCI NIH HHS / CA / R21 CA128495
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Polycomb-Group Proteins; 0 / Repressor Proteins
[Number-of-references]
85
[Other-IDs]
NLM/ NIHMS96703; NLM/ PMC2680753
8.
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH:
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.
N Engl J Med
; 2006 Dec 14;355(24):2542-50
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[Title]
Paclitaxel-carboplatin alone or with bevacizumab for non-small-
cell
lung cancer.
METHODS: Between July 2001 and April 2004, the Eastern Cooperative Oncology Group (ECOG) conducted a randomized study in which 878 patients with recurrent or advanced non-small-
cell
lung cancer (stage IIIB or IV) were assigned to chemotherapy with paclitaxel and carboplatin alone (444) or paclitaxel and carboplatin plus bevacizumab (434).
Chemotherapy was administered every 3 weeks for six cycles, and bevacizumab was administered every 3 weeks until
disease
progression was evident or toxic effects were intolerable.
Patients with
squamous
-
cell
tumors
, brain metastases, clinically significant hemoptysis, or inadequate organ function or performance status (ECOG performance status, >1) were excluded.
The median progression-free survival in the two groups was 6.2 and 4.5 months, respectively (hazard ratio for
disease
progression, 0.66; P<0.001), with corresponding response rates of 35% and 15% (P<0.001).
CONCLUSIONS: The addition of bevacizumab to paclitaxel plus carboplatin in the treatment of selected patients with non-small-
cell
lung cancer has a significant survival benefit with the risk of increased treatment-related deaths. (ClinicalTrials.gov number, NCT00021060. )
[MeSH-major]
Angiogenesis Inhibitors / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-
Cell
Lung / drug therapy. Lung
Neoplasms
/ drug therapy
[MeSH-minor]
Aged. Antibodies, Monoclonal, Humanized. Bevacizumab. Carboplatin / administration & dosage. Carboplatin / adverse effects.
Disease
-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Paclitaxel / administration & dosage. Paclitaxel / adverse effects. Vascular Endothelial Growth Factor A / blood
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.
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.
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.
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.
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.
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TAXOL
.
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CARBOPLATIN
.
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Cited by Patents in
.
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[Copyright]
2006 Massachusetts Medical Society
[CommentIn]
N Engl J Med. 2007 Mar 29;356(13):1373; author reply 1374-5
[
17396305.001
]
[CommentIn]
N Engl J Med. 2007 Mar 29;356(13):1373; author reply 1374-5
[
17392310.001
]
[CommentIn]
N Engl J Med. 2007 Mar 29;356(13):1374; author reply 1374-5
[
17396304.001
]
[CommentIn]
N Engl J Med. 2007 Mar 29;356(13):1373-4; author reply 1374-5
[
17396306.001
]
[ErratumIn]
N Engl J Med. 2007 Jan 18;356(3):318
(PMID = 17167137.001).
[ISSN]
1533-4406
[Journal-full-title]
The New England journal of medicine
[ISO-abbreviation]
N. Engl. J. Med.
[Language]
eng
[Databank-accession-numbers]
ClinicalTrials.gov/ NCT00021060
[Grant]
United States / NCI NIH HHS / CA / CA12046; United States / NCI NIH HHS / CA / CA14548; United States / NCI NIH HHS / CA / CA16116; United States / NCI NIH HHS / CA / CA21076; United States / NCI NIH HHS / CA / CA21115; United States / NCI NIH HHS / CA / CA23318; United States / NCI NIH HHS / CA / CA31946; United States / NCI NIH HHS / CA / CA49957; United States / NCI NIH HHS / CA / CA66636
[Publication-type]
Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
9.
Aréchaga-Ocampo E, Pereira-Suárez AL, del Moral-Hernández O, Cedillo-Barrón L, Rodríguez-Sastre MA, Castillo-Alvarez A, López-Bayghen E, Villegas-Sepúlveda N:
HPV+ cervical carcinomas and cell lines display altered expression of caspases.
Gynecol Oncol
; 2008 Jan;108(1):10-8
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[Title]
HPV+ cervical carcinomas and
cell
lines display altered expression of caspases.
OBJECTIVE: Loss of expression of apoptotic regulatory proteins in many
neoplasias
might result in defective or delayed apoptosis, thus facilitating
tumor
growth or survival.
We analyzed here, the basal expression of precursors of apoptotic Caspases in normal cervical epithelium, HPV+ cervical
tumor
samples and HPV+
tumor
-derived
cell
lines.
METHODS: Expression of initiator and effector Caspases was analyzed by immunochemistry in normal cervical epithelium and three types of cervical
tumors
(
squamous cell
carcinoma, adenocarcinoma and adenosquamous
cell
carcinoma) whereas expression of Caspases in HeLa, SiHa and CaSki cells was by immunofluorescence, Western blot and RT-PCR.
RESULTS: Expression of Caspases 3 and 9 was undetectable in adenocarcinoma and adenosquamous
cell
carcinoma, respectively.
Whereas in
squamous cell
carcinoma, the expression of Caspases was similar those observed in normal samples.
Expression of Caspases 3 and 6 was low in HeLa and CaSki cells, while Caspase 8 was low in SiHa and it was
not
detected in C33-A cells.
We did
not
observe an effect of the E6/E7 oncogenes on the expression of Caspases in C33-A
cell
.
CONCLUSION: Our results showed a differential expression of several Caspases in carcinoma samples and
cell
lines, suggesting multiple alterations of the Caspase pathways in cervical cancer.
[MeSH-major]
Caspases / biosynthesis. Papillomavirus Infections / enzymology. Uterine Cervical
Neoplasms
/ enzymology. Uterine Cervical
Neoplasms
/ virology
[MeSH-minor]
Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Adenocarcinoma / virology. Blotting, Western. Carcinoma, Adenosquamous / enzymology. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / virology. Carcinoma,
Squamous Cell
/ enzymology. Carcinoma,
Squamous Cell
/ pathology. Carcinoma,
Squamous Cell
/ virology.
Cell
Line,
Tumor
. Female. Fluorescent Antibody Technique. HeLa Cells. Human papillomavirus 16. Human papillomavirus 18. Humans. Immunohistochemistry. Isoenzymes / biosynthesis. Paraffin Embedding. Reverse Transcriptase Polymerase Chain Reaction
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.
International Agency for Research on Cancer - Screening Group.
diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas
.
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(PMID = 17936882.001).
[ISSN]
1095-6859
[Journal-full-title]
Gynecologic oncology
[ISO-abbreviation]
Gynecol. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Isoenzymes; EC 3.4.22.- / Caspases
10.
Safranek PM, Sujendran V, Baron R, Warner N, Blesing C, Maynard ND:
Oxford experience with neoadjuvant chemotherapy and surgical resection for esophageal adenocarcinomas and squamous cell tumors.
Dis Esophagus
; 2008;21(3):201-6
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[Title]
Oxford experience with neoadjuvant chemotherapy and surgical resection for esophageal adenocarcinomas and
squamous cell
tumors
.
Since February 2000 it has been our practice to offer this chemotherapy regime to patients with T2 and T3 or T1N1
tumors
.
Six patients (5.7%) had progressive
disease
and were inoperable (discovered in four at surgery).
A total of 182 patients with a median age of 63 (range 30-80), 41
squamous
and 141 adenocarcinomas underwent surgery.
A radical surgical approach to the primary
tumor
in combination with OEO2 neoadjuvant chemotherapy has led to a high R0 resection rate and good survival with acceptable morbidity and mortality.
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(PMID = 18430099.001).
[ISSN]
1442-2050
[Journal-full-title]
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
[ISO-abbreviation]
Dis. Esophagus
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
11.
Elamin I, Zecević RD, Vojvodić D, Medenica L, Pavlović MD:
Cytokine concentrations in basal cell carcinomas of different histological types and localization.
Acta Dermatovenerol Alp Pannonica Adriat
; 2008 Jun;17(2):55-9
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[Title]
Cytokine concentrations in basal
cell
carcinomas of different histological types and localization.
BACKGROUND: Basal
cell
carcinoma (BCC) is the most common malignant skin
tumor
.
Cytokines as major mediators of the immune system have been shown to play an important role in biology of the
neoplasm
with the general predomination of Th2 cytokines, whereas IFN-?
and other Th1 cytokines are prevalent in spontaneously regressing
tumors
.
OBJECTIVE: We were interested in comparing cytokine levels in BCC and cutaneous
squamous cell
tumors
with BCC of different localization and histological subtypes.
MATERIAL AND METHODS: Explants from freshly excised BCC from 18 patients, and cutaneous
squamous cell
tumors
(solar keratoses and Bowen's
disease
) from 9 patients were cultivated for 24 h.
RESULTS: Tissue explants of BCC contained significantly higher concentrations of IL-1beta, IL-4, IL-5, and IL-6 compared to those of
squamous cell
tumors
.
Higher levels of TNF-alpha (p = 0.042), IL-4 (p = 0.028), and IL-5 (p = 0.012) were found in
tumors
localized to the head and neck compared to those on the trunk or extremities.
Interleukin-6 concentrations were higher in aggressive BCC variants (infiltrative and micronodular), but the difference was
not
statistically significant (p = 0.068).
CONCLUSIONS: Confirming the earlier findings that BCC is
a tumor
with a Th2 cytokine microenvironment, this study further shows that BCC situated on the head and neck produce even more of certain Th2 cytokines (IL-4 and IL-5) and TNF-alpha, a crucial immunosuppressive cytokine released upon UVB irradiation.
[MeSH-major]
Carcinoma, Basal
Cell
/ chemistry. Cytokines / analysis. Skin
Neoplasms
/ chemistry
[MeSH-minor]
Aged. Carcinoma,
Squamous Cell
/ chemistry. Female. Humans. Interleukin-4 / analysis. Interleukin-5 / analysis. Male.
Tumor
Necrosis Factor-alpha / analysis
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.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 18709290.001).
[ISSN]
1318-4458
[Journal-full-title]
Acta dermatovenerologica Alpina, Pannonica, et Adriatica
[ISO-abbreviation]
Acta Dermatovenerol Alp Pannonica Adriat
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Slovenia
[Chemical-registry-number]
0 / Cytokines; 0 / Interleukin-5; 0 / Tumor Necrosis Factor-alpha; 207137-56-2 / Interleukin-4
12.
Jacob S, Mohapatra D:
Placental site nodule: a tumor-like trophoblastic lesion.
Indian J Pathol Microbiol
; 2009 Apr-Jun;52(2):240-1
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[Title]
Placental site nodule:
a tumor
-like trophoblastic lesion.
This entity may have bizarre histologic findings and should be distinguished from other aggressive lesions like placental site trophoblastic
tumor
, epithelioid trophoblastic
tumor
and
squamous cell
carcinoma.
[MeSH-major]
Gestational Trophoblastic
Disease
/ diagnosis. Placenta Diseases / pathology. Trophoblasts / pathology
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(PMID = 19332926.001).
[ISSN]
0974-5130
[Journal-full-title]
Indian journal of pathology & microbiology
[ISO-abbreviation]
Indian J Pathol Microbiol
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
India
13.
Gómez de la Fuente E, Sols M, Pinedo F, Alvarez-Fernández JG, Vicente FJ, Naz E, López-Estebaranz JL:
[Atypical fibroxanthoma. Clinical/pathological study of 10 cases].
Actas Dermosifiliogr
; 2005 Apr;96(3):153-8
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[Transliterated title]
Fibroxantoma atípico. Estudio clinicopatológico
de
10 casos.
INTRODUCTION: Atypical fibroxanthoma (AFX) is a rare
tumor
of unknown histogenesis, considered by most authorities as a superficial form of malignant fibrous histiocytoma (MFH).
Clinical (age, onset-diagnosis time, location, accompanying pathology, outcome), histological (architectural pattern,
cell
type, ulceration, vascular or perineural invasion, subcutis involvement, pleomorphism, mitosis, inflammatory infiltrate) and immunohistochemical variable were analyzed.
Pathologically all the cases showed a spindle-
cell
prevalence arranged in a vaguely storiform pattern, along with both, multinucleated and eosinophilic cells.
Other spindle-
cell
tumors
such as
squamous cell
carcinoma, malignant melanoma, leyomiosarcoma or dermatofibrosarcoma protuberans must be ruled out by immunohistochemical techniques.
[MeSH-major]
Histiocytoma, Benign Fibrous / pathology. Skin
Neoplasms
/ pathology
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(PMID = 16476356.001).
[ISSN]
0001-7310
[Journal-full-title]
Actas dermo-sifiliográficas
[ISO-abbreviation]
Actas Dermosifiliogr
[Language]
spa
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Spain
1
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4.
Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, McGinn TG, Wisnivesky JP:
Racial disparities in esophageal cancer treatment and outcomes.
Ann Surg Oncol
; 2008 Mar;15(3):881-8
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Blacks were more likely to be diagnosed at a more advanced stage and to have
squamous cell
tumors
, but were less likely to undergo surgery.
In multivariate regression controlling for age, sex, marital status, histology, and
tumor
location, black race was associated with worse survival.
When
tumor
status, surgery, and radiotherapy were added to the model, race was no longer significantly associated with survival.
While the disparity is due in part to differences in
tumor
histology, diagnosis at an earlier stage and higher rates of surgery among blacks could reduce this survival disparity.
[MeSH-major]
Adenocarcinoma / ethnology. Carcinoma,
Squamous Cell
/ ethnology. Esophageal
Neoplasms
/ ethnology. Esophageal
Neoplasms
/ therapy. Healthcare Disparities
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[CommentIn]
Ann Surg Oncol. 2008 Mar;15(3):674-6
[
18095032.001
]
(PMID = 17987341.001).
[ISSN]
1534-4681
[Journal-full-title]
Annals of surgical oncology
[ISO-abbreviation]
Ann. Surg. Oncol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
15.
Demarosi F, Lodi G, Carrassi A, Soligo D, Sardella A:
Oral malignancies following HSCT: graft versus host disease and other risk factors.
Oral Oncol
; 2005 Oct;41(9):865-77
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[Title]
Oral malignancies following HSCT: graft versus host
disease
and other risk factors.
Allogenic hematopoietic stem
cell
transplantation (HSCT), a procedure that is widely used in the treatment of a large number of malignant and non-malignant hematological diseases, is still associated with a wide range of complications, one of the most important of which is graft versus host
disease
(GVHD).
The patients undergoing allogenic HSCT are also at high risk of developing secondary
neoplasms
, particularly leukemias and lymphomas.
Solid
tumors
are less frequent, and the incidence appears to increase over time; the most frequent solid
tumors
are
squamous cell
carcinomas.
They include graft versus host
disease
(GVHD), preoperative regimens, with either radio-chemotherapy or chemotherapy alone, conditioning regimes, immunosuppressive GVHD prophylaxis, viral infection and chronic stimulation as a result of viral antigens, antigenic stimulation from histocompatibility differences between recipient and donor, primary diagnosis, interaction of any of these factors with genetic predisposition, and other factors such as sex and age.
All patients treated with HSCT should therefore be closely followed over the long term with the aim of identifying the onset of secondary
tumors
as early as possible.
[MeSH-major]
Carcinoma,
Squamous Cell
/ etiology. Graft vs Host
Disease
/ etiology. Hematopoietic Stem
Cell
Transplantation / adverse effects. Mouth
Neoplasms
/ etiology.
Neoplasms
, Second Primary / etiology
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(PMID = 16084755.001).
[ISSN]
1368-8375
[Journal-full-title]
Oral oncology
[ISO-abbreviation]
Oral Oncol.
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Number-of-references]
39
16.
Matsumoto K, Hyodo F, Matsumoto A, Koretsky AP, Sowers AL, Mitchell JB, Krishna MC:
High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.
Clin Cancer Res
; 2006 Apr 15;12(8):2455-62
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[Title]
High-resolution mapping of
tumor
redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.
The levels of 3CP were examined by EPRI and MRI for differences in reduction between muscle and
tumor
(
squamous cell
carcinoma) implanted in the hind leg of C3H mice simultaneously.
The
tumor
regions exhibited a faster decay rate of the nitroxide compared to muscle (0.097 min(-1) versus 0.067 min(-1), respectively).
[MeSH-major]
Magnetic Resonance Imaging / methods.
Neoplasms
, Experimental / pathology. Nitrogen Oxides / chemistry
[MeSH-minor]
Animals. Carcinoma,
Squamous Cell
/ metabolism. Carcinoma,
Squamous Cell
/ pathology. Cyclic N-Oxides / chemistry. Cyclic N-Oxides / metabolism. Electron Spin Resonance Spectroscopy / methods. Female. Mice. Mice, Inbred C3H. Models, Chemical. Muscles / metabolism. Oxidation-Reduction. Pyrrolidines / chemistry. Pyrrolidines / metabolism
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(PMID = 16638852.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / / Z01 NS003047-01
[Publication-type]
Comparative Study; Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Cyclic N-Oxides; 0 / Nitrogen Oxides; 0 / Pyrrolidines; 14332-28-6 / nitroxyl; 4399-80-8 / 3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-N-oxyl
17.
Wilson MK, Granger EK, Preda VA:
Pulmonary hypertension due to isolated metastatic squamous cell carcinoma thromboemboli.
Heart Lung Circ
; 2006 Apr;15(2):143-5
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[Title]
Pulmonary hypertension due to isolated metastatic
squamous cell
carcinoma thromboemboli.
The differential diagnosis of pulmonary hypertension due to arterial
tumour
embolism is often overlooked and deserves contemplation.
This resulted in the surprising definitive diagnosis of thromboembolic pulmonary hypertension secondary to laminated thrombi of metastatic
squamous cell
tumour
emboli.
The site of
tumour
origin was however
not
histologically apparent and was unable to be elucidated on extensive further investigation.
[MeSH-major]
Arterial Occlusive Diseases / diagnosis. Hypertension, Pulmonary / diagnosis.
Neoplasms
,
Squamous Cell
/ diagnosis. Pulmonary Embolism / diagnosis. Thromboembolism / diagnosis
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(PMID = 16412689.001).
[ISSN]
1443-9506
[Journal-full-title]
Heart, lung & circulation
[ISO-abbreviation]
Heart Lung Circ
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
18.
Fuld AD, Dragnev KH, Rigas JR:
Pemetrexed in advanced non-small-cell lung cancer.
Expert Opin Pharmacother
; 2010 Jun;11(8):1387-402
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[Title]
Pemetrexed in advanced non-small-
cell
lung cancer.
IMPORTANCE OF THE FIELD: Current therapeutic options for advanced non-small-
cell
lung cancer (NSCLC) yield relatively modest improvements in survival leading to an ongoing search for new active treatment agents.
The efficacy of pemetrexed seems to vary between
squamous
and nonsquamous histologies.
There is growing evidence that, in patients treated with pemetrexed, nonsquamous
tumors
have improved outcomes compared to
squamous cell
tumors
.
[MeSH-major]
Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Non-Small-
Cell
Lung / drug therapy. Glutamates / therapeutic use. Guanine / analogs & derivatives. Lung
Neoplasms
/ drug therapy
[MeSH-minor]
Carcinoma,
Squamous Cell
/ drug therapy. Carcinoma,
Squamous Cell
/ metabolism. Carcinoma,
Squamous Cell
/ mortality. Carcinoma,
Squamous Cell
/ pathology. Clinical Trials, Phase II as Topic. Clinical Trials, Phase III as Topic. Humans. Pemetrexed. Survival Rate. Treatment Outcome
Genetic Alliance.
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.
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.
MedlinePlus Health Information.
consumer health - Lung Cancer
.
Hazardous Substances Data Bank.
PEMETREXED
.
Hazardous Substances Data Bank.
GUANINE
.
NCI CPTAC Assay Portal.
NCI CPTAC Assay Portal
.
SciCrunch.
DrugBank: Data: Chemical
.
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(PMID = 20446853.001).
[ISSN]
1744-7666
[Journal-full-title]
Expert opinion on pharmacotherapy
[ISO-abbreviation]
Expert Opin Pharmacother
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Antimetabolites, Antineoplastic; 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine
[Number-of-references]
92
19.
Yilmaz A, Savaş I, Dizbay Sak S, Güngör A, Kaya A, Serinsöz E, Savaş B:
Distribution of Bcl-2 gene expression and its prognostic value in non-small cell lung cancer.
Tuberk Toraks
; 2005;53(4):323-9
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[Title]
Distribution of Bcl-2 gene expression and its prognostic
value
in non-small
cell
lung cancer.
The aim of this study was to determine the expression of Bcl-2 gene and prognostic importance of Bcl-2 expression in paraffin embedded blocks of patients diagnosed with non-small
cell
lung cancer (NSCLC).
These sections are transferred on to slides covered with poly-L-lysine, then
de
-paraffinization was made.
Positive staining was observed in 9 (19.6%) patients, but
not
in 37 (80.4%) patients.
Out of 32 cases with
squamous cell
tumor
, 8 (25%) were observed to have positive staining in their sections, but 24 (75%) were
not
so.
No staining was observed in 11 cases whose
cell
type was adenoma and two cases whose
cell
type was adenosquamos (100%).
Staining was present in the section of one case with large
cell
(100%).
Median survival time was 36.6 months in cases in which staining was observed and 6.10 months in cases in which staining was
not
observed, with a significant difference (p< 0.05).
[MeSH-major]
Carcinoma, Non-Small-
Cell
Lung / genetics. Gene Expression Regulation, Neoplastic. Genes, bcl-2. Lung
Neoplasms
/ genetics. Proto-Oncogene Proteins c-bcl-2 / biosynthesis
[MeSH-minor]
Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adult. Aged. Biomarkers,
Tumor
/ metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate
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(PMID = 16456730.001).
[ISSN]
0494-1373
[Journal-full-title]
Tüberküloz ve toraks
[ISO-abbreviation]
Tuberk Toraks
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Turkey
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2
20.
Pajor A, Stańczyk R, Durko T:
[Malignant neoplasms of external and middle ear].
Otolaryngol Pol
; 2005;59(2):251-6
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[Title]
[Malignant
neoplasms
of external and middle ear].
[Transliterated title]
Nowotwory
złośliwe ucha zewnetrznego i środkowego.
INTRODUCTION:
Neoplasms
of external and middle ear are rare, which cause several problems in diagnosis and therapy.
The purpose of the study was to analyze retrospectively patients with malignant
neoplasms
of the ear.
METHODOLOGY: The study was carried out on 53 patients treated for malignant ear
neoplasms
in single institution during 25 years (1978-2002).
RESULTS: The most frequent
neoplasm
was
squamous cell
carcinoma--36 cases (67.9%), then basal
cell
carcinoma--9 cases (16.9%).
Neoplasm
primarily involved auricle in 26 patients (49.1%), external auditory canal in 15 patients (28.3%) and middle ear in 12 patients (22.6%).
The characteristics of
neoplasms
related to the site of location were described.
The difficulties in precise histopathologic diagnosis and extent of
disease
were pointed out.
RESULTS:
Neoplasms
of external and middle ear constitute a group of various histopathological and clinical tumours, which differ in diagnostic difficulties, treatment and prognosis.
A diagnosis was often made in advanced stages of
neoplasms
, especially for middle ear tumours, that diminished a possibility of effective treatment.
[MeSH-major]
Ear
Neoplasms
/ pathology. Ear, External. Ear, Middle
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Carcinoma, Basal
Cell
/ pathology. Carcinoma, Basal
Cell
/ therapy. Carcinoma,
Squamous Cell
/ pathology. Carcinoma,
Squamous Cell
/ therapy. Diagnosis, Differential. Female. Humans. Male. Middle Aged.
Neoplasm
Staging. Ossicular Prosthesis. Retrospective Studies
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(PMID = 16095097.001).
[ISSN]
0030-6657
[Journal-full-title]
Otolaryngologia polska = The Polish otolaryngology
[ISO-abbreviation]
Otolaryngol Pol
[Language]
pol
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Poland
21.
Zhang LN, Xiao ZP, Ding H, Ge HM, Xu C, Zhu HL, Tan RX:
Synthesis and cytotoxic evaluation of novel 7-O-modified genistein derivatives.
Chem Biodivers
; 2007 Feb;4(2):248-55
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The cytotoxic activities of these compounds were evaluated against human chronic myeloid leukemia cells (K562) and a human nasopharyngeal
epidermoid tumor
cell
line (KB).
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(PMID = 17311236.001).
[ISSN]
1612-1880
[Journal-full-title]
Chemistry & biodiversity
[ISO-abbreviation]
Chem. Biodivers.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Switzerland
[Chemical-registry-number]
0 / Antineoplastic Agents; DH2M523P0H / Genistein
22.
Lo WC, Ting LL, Ko JY, Lou PJ, Yang TL, Chang YL, Wang CP:
Malignancies of the ear in irradiated patients of nasopharyngeal carcinoma.
Laryngoscope
; 2008 Dec;118(12):2151-5
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RESULTS: Ten
tumors
were
squamous cell
carcinoma and one
tumor
was chondrosarcoma occurring within the radiation field of previous treatment for NPC.
Six
tumors
were located in the external auditory canal, two in the middle ear cavity, two in the periauricular region and one in the mastoid cavity.
The 3-year
disease
-free and overall survival rates were 30.3% and 20%, respectively.
[MeSH-major]
Carcinoma,
Squamous Cell
/ etiology. Chondrosarcoma / etiology. Ear
Neoplasms
/ etiology. Nasopharyngeal
Neoplasms
/ radiotherapy.
Neoplasms
, Radiation-Induced / etiology.
Neoplasms
, Second Primary / etiology
[MeSH-minor]
Adult. Aged. Aged, 80 and over. Combined Modality Therapy.
Disease
-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged.
Neoplasm
Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies
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(PMID = 18948828.001).
[ISSN]
1531-4995
[Journal-full-title]
The Laryngoscope
[ISO-abbreviation]
Laryngoscope
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
23.
Carlson M, Wuertz B, Lin J, Taylor R, Ondrey F:
Exons 19 and 21 of epidermal growth factor receptor are highly conserved in squamous cell cancer of the head and neck.
Int J Otolaryngol
; 2009;2009:649615
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[Title]
Exons 19 and 21 of epidermal growth factor receptor are highly conserved in
squamous cell
cancer of the head and neck.
EGFR inhibitors might be more effective in patients whose
tumors
harbor specific EGFR mutations.
The presence of specific EFGR mutations is predictive of over a 75% response rate to TKI therapies as compared to 10% in wild type cases of non-small
cell
lung cancer.
Design. DNA was extracted from 20 head and neck
squamous cell
tumors
and 4
squamous cell
carcinoma
cell
lines and sequenced the receptor using published primer pairs.
Results. No exon 19 or 21 mutations were found in any of the 20
tumors
and 0 of 4
cell
lines.
Based on the
tumor
data we would predict that no greater than 8% of head and neck
tumors
(CI 97.5%) would be likely to harbor either of these mutations.
Conclusions. Our findings are comparable to results recently published of Korean, Austrian, and Spanish patient populations and we conclude that exon 19 and 21 EGFR mutations are
not
more common in head and neck cancer than in nonsmall-
cell
carcinoma.
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[Cites]
Cancer Cell. 2002 Jun;1(5):413-5
[
12124170.001
]
[Cites]
Tumour Biol. 2007;28(5):273-9
[
17962724.001
]
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J Clin Oncol. 2004 Jan 1;22(1):77-85
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[
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Clin Cancer Res. 2006 Jul 1;12(13):3908-14
[
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[Cites]
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[
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[Cites]
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[
17661350.001
]
[Cites]
J Clin Oncol. 2003 May 15;21(10):1980-7
[
12743152.001
]
(PMID = 20130810.001).
[ISSN]
1687-921X
[Journal-full-title]
International journal of otolaryngology
[ISO-abbreviation]
Int J Otolaryngol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2814135
24.
Pesek M, Benesova L, Belsanova B, Mukensnabl P, Bruha F, Minarik M:
Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status.
Anticancer Res
; 2009 Jul;29(7):2767-73
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[Title]
Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by
tumor
subtype and smoking status.
Mutations in EGFR (exon 19 and 21) and KRAS (codons 12 and 13) and their impact on response and survival with respect to
tumor
subtype and smoking status were assessed.
No EGFR effect was recorded for
squamous cell
tumors
.
KRAS mutation in
tumors
did
not
result in a poorer prognosis in the subtype-selected groups, nor did it present as a negative factor in smokers.
KRAS does
not
seem an "a priori" negative factor for TKI-based treatment of NSCLC.
[MeSH-major]
Carcinoma, Non-Small-
Cell
Lung / drug therapy. Genes, ras. Lung
Neoplasms
/ drug therapy. Mutation. Protein Kinase Inhibitors / therapeutic use. Receptor, Epidermal Growth Factor / genetics. Smoking
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(PMID = 19596959.001).
[ISSN]
1791-7530
[Journal-full-title]
Anticancer research
[ISO-abbreviation]
Anticancer Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Greece
[Chemical-registry-number]
0 / Codon; 0 / DNA Primers; 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
25.
Kim Y, Liu XS, Liu C, Smith DE, Russell RM, Wang XD:
Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer.
Cancer Lett
; 2006 Mar 28;234(2):209-19
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[Title]
Induction of pulmonary
neoplasia
in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer.
Results showed that six out 12 ferrets exposed to both NNK injection and cigarette smoke developed grossly identifiable lung
tumors
whereas none of nine ferrets from the sham treatment group developed any lung lesions.
The histopathological types of these
tumors
(
squamous cell
carcinoma, adenosquamous carcinoma and adenocarcinoma) in ferret lungs are very similar to those in humans.
In addition, 10 out of 12 ferrets exposed to both NNK and cigarette smoke developed preneoplastic lesions (
squamous
metaplasia, dysplasia, and atypical adenomatous hyperplasia) with complex growth patterns whereas the sham group did
not
show any of these lesions.
Furthermore, the expression of proliferating cellular nuclear antigen increased markedly in both gross
tumors
and preneoplastic lesions in the lungs.
In summary, the development of both preneoplastic lesions and gross lung
tumors
in ferrets provides an excellent and unique model for studying lung cancer chemoprevention with agents such as carotenoids, and for studying the molecular mechanism of carcinogenesis in the earlier stages of smoke-related lung cancer.
[MeSH-major]
Carcinogens / toxicity.
Disease
Models, Animal. Ferrets. Lung
Neoplasms
/ etiology. Nitrosamines / toxicity. Smoking / adverse effects
[MeSH-minor]
Adenocarcinoma / etiology. Adenocarcinoma / pathology. Animals. Carcinoma,
Squamous Cell
/ etiology. Carcinoma,
Squamous Cell
/ pathology. Humans. Immunohistochemistry. Male. Precancerous Conditions / etiology. Precancerous Conditions / pathology
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author profiles
.
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4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
.
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(PMID = 15894421.001).
[ISSN]
0304-3835
[Journal-full-title]
Cancer letters
[ISO-abbreviation]
Cancer Lett.
[Language]
eng
[Grant]
United States / NIDDK NIH HHS / DK / T32 DK062032
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
Ireland
[Chemical-registry-number]
0 / Carcinogens; 0 / Nitrosamines; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
26.
Guimarães Vde C, Viana MA, Barbosa MA, Paiva ML, Tavares JA, Camargo LA:
[Vocal care: question of prevention and health].
Cien Saude Colet
; 2010 Sep;15(6):2799-803
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[Transliterated title]
Cuidados vocais: questão
de
prevenção e saúde.
Considering all the patients attended, only one presented malignant
neoplasm
(
squamous cell
carcinoma), confirmed later by biopsy.
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(PMID = 20922288.001).
[ISSN]
1678-4561
[Journal-full-title]
Ciência & saúde coletiva
[ISO-abbreviation]
Cien Saude Colet
[Language]
por
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Brazil
27.
Narumi T, Kozawa E, Heshiki A, Tomoda M, Shimizu Y:
CT and MRI findings of a solitary extramedullary plasmacytoma of the oropharynx: case report.
Radiat Med
; 2005 Dec;23(8):574-7
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A mass was endoscopically detected in his right posterior oropharyngeal wall, and biopsy revealed
a neoplasm
consisting of a uniform population of plasma cells.
Computed tomography (CT) showed a broad-based papillary soft tissue density mass projecting into the oropharynx from the right posterior wall of the pharynx, and post-contrast CT showed marked enhancement of the
tumor
.
The
tumor
showed slightly higher signal intensity compared with surrounding muscle on MR Tl-weighted images (T1WI) and high signal intensity on MR T2-weighted images (T2WI).
Following radiation therapy, a reduction in
tumor
size was observed.
Although SEP is a rare
tumor
, it should be included in the differential diagnosis of
tumors
of the oropharynx because of its imaging similarities to other, more common malignant
tumors
, such as
squamous cell
carcinoma and lymphoma.
[MeSH-major]
Oropharyngeal
Neoplasms
/ diagnosis. Plasmacytoma / diagnosis
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(PMID = 16555568.001).
[ISSN]
0288-2043
[Journal-full-title]
Radiation medicine
[ISO-abbreviation]
Radiat Med
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Japan
28.
Andratschke M, Stelter K, Ihrler S, Hagedorn H:
Subglottic tracheal stenosis as primary manifestation of a marginal zone B-cell lymphoma of the larynx.
In Vivo
; 2005 May-Jun;19(3):547-50
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[Title]
Subglottic tracheal stenosis as primary manifestation of a marginal zone B-
cell
lymphoma of the larynx.
BACKGROUND: More than 90% of laryngeal
tumors
are
squamous cell
carcinomas.
Primary hematopoetic
neoplasms
of the larynx are rare, being mainly extramedullary plasmocytoma and non-Hodgkin's lymphoma (NHL).
The biopsy revealed the diagnosis of a MALT-type lymphoma (marginal zone B-
cell
lymphoma).
[MeSH-major]
Laryngeal
Neoplasms
/ diagnosis. Lymphoma, B-
Cell
, Marginal Zone / diagnosis. Tracheal Stenosis / etiology
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(PMID = 15875774.001).
[ISSN]
0258-851X
[Journal-full-title]
In vivo (Athens, Greece)
[ISO-abbreviation]
In Vivo
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Greece
29.
Ferraz JG, Martins AL, de Souza JF, Matos A, Canto AP, Martins AM:
Metastatic tumor of squamous cell carcinoma from uterine cervix to heart: ante-mortem diagnosis.
Arq Bras Cardiol
; 2006 Oct;87(4):e104-7
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[Title]
Metastatic
tumor
of
squamous cell
carcinoma from uterine cervix to heart: ante-mortem diagnosis.
The pathological examination revealed metastasis of
squamous
cells with well-differentiated infiltrative areas.
Four months later, however, she was readmitted to hospital in terminal stage, confirming the guarded prognosis of the
disease
at this stage.
[MeSH-major]
Carcinoma,
Squamous Cell
/ secondary. Heart
Neoplasms
/ secondary. Uterine Cervical
Neoplasms
/ pathology
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.
International Agency for Research on Cancer - Screening Group.
diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas
.
International Agency for Research on Cancer - Screening Group.
diagnostics - A practical manual on visual screening for cervical neoplasia
.
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(PMID = 17128293.001).
[ISSN]
1678-4170
[Journal-full-title]
Arquivos brasileiros de cardiologia
[ISO-abbreviation]
Arq. Bras. Cardiol.
[Language]
eng; por
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Brazil
30.
Mandic A, Novakovic P, Mihajlovic O, Stojiljkovic B, Rajovic J, Davidovic M:
Clinical staging and histopathological findings after radical hysterectomy in FIGO stage IIB cervical cancer.
J BUON
; 2008 Jan-Mar;13(1):51-4
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The histopathological types of cervical
tumors
were:
squamous cell
carcinoma 80%, adenosquamous carcinoma 15% and adenocarcinoma 5%.
[MeSH-major]
Hysterectomy. Uterine Cervical
Neoplasms
/ pathology
[MeSH-minor]
Adult. Female. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Middle Aged.
Neoplasm
Staging
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International Agency for Research on Cancer - Screening Group.
diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas
.
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(PMID = 18404786.001).
[ISSN]
1107-0625
[Journal-full-title]
Journal of B.U.ON. : official journal of the Balkan Union of Oncology
[ISO-abbreviation]
J BUON
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
31.
Shah S, Shukla K, Patel P:
Role of fine needle aspiration cytology in diagnosis of lung tumours--a study of 100 cases.
Indian J Pathol Microbiol
; 2007 Jan;50(1):56-8
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The aim of this study was to assess the usefulness of fine needle aspiration cytology (FNAC) as a diagnostic method in lung
tumour
as well as to determine the incidence of lung cancer in various age and sex group and in relation with smoking.
The most common
tumour
was
squamous cell
carcinoma (45%) followed by adenocarcinoma (22%), small
cell
carcinoma (16%) and large
cell
carcinoma (8%).
[MeSH-major]
Biopsy, Fine-Needle. Lung
Neoplasms
/ diagnosis
[MeSH-minor]
Adenocarcinoma / diagnosis. Adenocarcinoma / epidemiology. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Large
Cell
/ diagnosis. Carcinoma, Large
Cell
/ epidemiology. Carcinoma, Small
Cell
/ diagnosis. Carcinoma, Small
Cell
/ epidemiology. Carcinoma,
Squamous Cell
/ diagnosis. Carcinoma,
Squamous Cell
/ epidemiology. Cytodiagnosis. Female. Histocytochemistry. Humans. Male. Middle Aged. Predictive
Value
of Tests. Risk Factors. Smoking
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(PMID = 17474260.001).
[ISSN]
0377-4929
[Journal-full-title]
Indian journal of pathology & microbiology
[ISO-abbreviation]
Indian J Pathol Microbiol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
India
32.
Marom EM, Martinez CH, Truong MT, Lei X, Sabloff BS, Munden RF, Gladish GW, Herbst RS, Morice RC, Stewart DJ, Jimenez CA, Blumenschein GR Jr, Onn A:
Tumor cavitation during therapy with antiangiogenesis agents in patients with lung cancer.
J Thorac Oncol
; 2008 Apr;3(4):351-7
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[Title]
Tumor
cavitation during therapy with antiangiogenesis agents in patients with lung cancer.
Tumor
cavitation is frequently noted in these patients, but the clinical significance of this
finding
has
not
been fully determined.
Our purposes were to evaluate the frequency, imaging characteristics, and clinical outcome of patients receiving antiangiogenesis agents who develop
tumor
cavitation, and correlate these findings with therapy related adverse events, especially hemoptysis.
Seventeen patients developed
tumor
cavitation during the trial (14%; median time to event, 1.8 months; range, 0.7-6.2 months), 16 patients (13%) had preexisting cavitary
tumors
, and 91 (73%) did
not
develop cavitation.
Cavity formation was more common with
squamous cell
histology (p = 0.04) but was
not
associated with hemoptysis (p = 0.12),
tumor
location (central versus peripheral), imaging characteristics, progression-free survival (p = 0.56), or overall survival (p = 0.33).
One of five patients with hemoptysis was fatal in a cavitary
squamous cell
tumor
.
CONCLUSION: Development of
tumor
cavitation is
not
rare in lung cancer patients treated with antiangiogenesis agents, but the clinical implications are minimal in most cases.
[MeSH-major]
Angiogenesis Inhibitors / therapeutic use. Carcinoma, Non-Small-
Cell
Lung / drug therapy. Lung
Neoplasms
/ drug therapy
[MeSH-minor]
Adenocarcinoma, Bronchiolo-Alveolar / blood supply. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Adult. Aged. Aged, 80 and over. Carcinoma, Large
Cell
/ blood supply. Carcinoma, Large
Cell
/ drug therapy. Carcinoma, Large
Cell
/ secondary. Carcinoma,
Squamous Cell
/ blood supply. Carcinoma,
Squamous Cell
/ drug therapy. Carcinoma,
Squamous Cell
/ secondary. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate
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(PMID = 18379352.001).
[ISSN]
1556-1380
[Journal-full-title]
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
[ISO-abbreviation]
J Thorac Oncol
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Angiogenesis Inhibitors
33.
Hamadah I, Binamer Y, Alajlan S, Nassar A, Saleh AJ:
Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation.
Hematol Oncol Stem Cell Ther
; 2010;3(2):84-8
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[Title]
Squamous cell
carcinoma of the lip after allogeneic hemopoietic stem
cell
transplantation.
Allogeneic hemopoietic stem
cell
transplantation (HSCT) has been considered a curative treatment option for many hematological and non-hematological disorders.
Despite the use of advanced methods of tissue typing and new therapies, graft versus host
disease
(GVHD) remains a major obstacle.
Secondary malignancies are also among the most serious long-term complications after HSCT including leukemia, lymphomas, and to a lesser extent, solid
tumors
.
The most commonly observed solid
tumor
is
squamous cell
carcinoma (SCC).
[MeSH-major]
Carcinoma,
Squamous Cell
/ pathology. Carcinoma,
Squamous Cell
/ surgery. Hematopoietic Stem
Cell
Transplantation. Lip
Neoplasms
/ pathology. Lip
Neoplasms
/ surgery.
Neoplasms
, Second Primary / pathology.
Neoplasms
, Second Primary / surgery
[MeSH-minor]
Adult. Graft vs Host
Disease
/ pathology. Graft vs Host
Disease
/ surgery. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Male. Multiple Myeloma / pathology. Multiple Myeloma / therapy. Transplantation, Homologous
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(PMID = 20543542.001).
[ISSN]
1658-3876
[Journal-full-title]
Hematology/oncology and stem cell therapy
[ISO-abbreviation]
Hematol Oncol Stem Cell Ther
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Saudi Arabia
34.
Li XJ, Lin M, Liu CY, Xie HL:
[Expression and clinical significance of EMS1 gene in gastric carcinoma].
Ai Zheng
; 2008 Mar;27(3):323-6
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BACKGROUND & OBJECTIVE: EMS1 (chromosome eleven, band q13, mammary
tumor
and
squamous cell
carcinoma-associated gene 1) is correlated to the genesis, progression, invasion and metastasis of some malignancies.
METHODS: The expression of EMS1 protein in 20 specimens of normal gastric mucosa, 38 specimens of intraepithelial
neoplasia
, and 146 specimens of gastric carcinoma was detected by immunohistochemistry.
The positive rate of EMS1 protein was significantly higher in gastric carcinoma than in intraepithelial
neoplasia
and normal gastric mucosa (89.7% vs. 68.4% and 20.0%, P<0.001), and significantly higher in intraepithelial
neoplasia
than in normal gastric mucosa (P<0.001).
EMS1 protein expression had no correlations to sex, age,
tumor
differentiation and diameter.
[MeSH-major]
Cortactin / genetics. Stomach
Neoplasms
/ genetics
[MeSH-minor]
Adult. Aged. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged.
Neoplasm
Staging
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(PMID = 18334127.001).
[Journal-full-title]
Ai zheng = Aizheng = Chinese journal of cancer
[ISO-abbreviation]
Ai Zheng
[Language]
chi
[Publication-type]
English Abstract; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
China
[Chemical-registry-number]
0 / CTTN protein, human; 0 / Cortactin
35.
Kanner WA, Galgano MT, Atkins KA:
Podoplanin expression in basal and myoepithelial cells: utility and potential pitfalls.
Appl Immunohistochem Mol Morphol
; 2010 May;18(3):226-30
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In addition, many salivary gland
tumors
and
squamous cell
carcinomas had strong D2-40 expression, sometimes making distinction of lymphatics versus
tumor
edge staining difficult.
D2-40 is excellent for assessing lymphatic invasion in breast, prostate, and cervix as long as the pathologist is aware of the expression in myoepithelial cells/basal cells to avoid misinterpretation of ductal carcinoma in situ or normal prostate glands or
tumor
stroma retraction as
tumor
lymphatic invasion.
Given the patchy positivity in basal cells of skin and mucosa and the reactivity in
squamous cell
carcinoma, D2-40 was
not
helpful in assessing for microinvasion of
squamous cell
carcinoma.
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(PMID = 20042851.001).
[ISSN]
1533-4058
[Journal-full-title]
Applied immunohistochemistry & molecular morphology : AIMM
[ISO-abbreviation]
Appl. Immunohistochem. Mol. Morphol.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Membrane Glycoproteins; 0 / PDPN protein, human
36.
McAllister KA, Houle CD, Malphurs J, Ward T, Collins NK, Gersch W, Wharey L, Seely JC, Betz L, Bennett LM, Wiseman RW, Davis BJ:
Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.
Toxicol Pathol
; 2006;34(2):187-98
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[Title]
Spontaneous and irradiation-induced
tumor
susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.
Mutations in both p53 and BRCA2 are commonly seen together in human
tumors
suggesting that the loss of both genes enhances
tumor
development.
We found decreased survival and timing of
tumor
onsets, and significantly higher overall
tumor
incidences and prevalence of particular
tumors
, including stomach
tumors
and
squamous cell
carcinomas, associated with the homozygous loss of Brca2, independent of p53 status.
The addition of a p53 mutation had a further impact on overall survival, incidence of osteosarcomas and stomach
tumors
, and
tumor
latency.
The spectrum of
tumors
observed for this Brca2 germline mouse model suggest that it faithfully recapitulates some human
disease
phenotypes associated with BRCA2 loss.
In addition, these findings include extensive in vivo data demonstrating that germline Brca2 and p53 mutations cooperatively affect animal survivals,
tumor
susceptibilities, and
tumor
onsets.
[MeSH-major]
BRCA2 Protein / genetics. Genes, p53. Germ-Line Mutation.
Neoplasms
/ genetics.
Neoplasms
, Radiation-Induced / genetics. Radiation, Ionizing
[MeSH-minor]
Animals. Bone
Neoplasms
/ genetics. Bone
Neoplasms
/ physiopathology. Carcinoma,
Squamous Cell
/ genetics. Carcinoma,
Squamous Cell
/ physiopathology. Female. Gene Expression Regulation, Neoplastic. Genetic Predisposition to
Disease
. Genotype. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Osteosarcoma / genetics. Osteosarcoma / physiopathology. Phenotype. Stomach
Neoplasms
/ genetics. Stomach
Neoplasms
/ physiopathology. Survival Rate. Time Factors
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(PMID = 16546942.001).
[ISSN]
0192-6233
[Journal-full-title]
Toxicologic pathology
[ISO-abbreviation]
Toxicol Pathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / BRCA2 Protein; 0 / BRCA2 protein, mouse
37.
Tango Y, Kano R, Maruyama H, Asano K, Tanaka S, Hasegawa A, Kamata H:
Detection of autoantibodies against survivin in sera from cancer dogs.
J Vet Med Sci
; 2010 Jul;72(7):917-20
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Survivin overexpression has been reported in relation to
tumor
malignancy, suggesting that it is an unfavorable prognostic marker, and antibody responses to this protein have been confirmed in human cancer patients.
The cut-off
value
for positivity in the anti-survivin ELISA was 0.35, as determined using the mean absorbance +2 S.D. of samples from healthy dogs.
Sera from 16 of 59 (27.1%) cancer and 3 of 25 (12%) non-cancer
disease
dogs were positive on ELISA.
The highest positivity rates (>50%) among the cancer cases were seen in dogs with mammary
tumor
,
squamous cell
carcinoma and melanoma.
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(PMID = 20179386.001).
[ISSN]
0916-7250
[Journal-full-title]
The Journal of veterinary medical science
[ISO-abbreviation]
J. Vet. Med. Sci.
[Language]
ENG
[Publication-type]
Journal Article
[Publication-country]
Japan
[Chemical-registry-number]
0 / Autoantibodies; 0 / DNA Primers; 0 / Microtubule-Associated Proteins
38.
Sahai A, Kodner IJ:
Premalignant neoplasms and squamous cell carcinoma of the anal margin.
Clin Colon Rectal Surg
; 2006 May;19(2):88-93
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[Title]
Premalignant
neoplasms
and
squamous cell
carcinoma of the anal margin.
Understanding anal anatomy and performing a biopsy of any suspicious lesions are essential in avoiding a delay in diagnosis and appropriately treating these
tumors
.
Combined multimodality treatment has come to play an important role in managing patient with more advanced or metastatic
disease
.
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(PMID = 20011315.001).
[ISSN]
1530-9681
[Journal-full-title]
Clinics in colon and rectal surgery
[ISO-abbreviation]
Clin Colon Rectal Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Other-IDs]
NLM/ PMC2780101
[Keywords]
NOTNLM ; Anus neoplasms / Bowen's disease / Paget's disease / squamous cell cancer
39.
Plaza JA, Ortega PF, Bengana C, Stockman DL, Suster S:
Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases.
Am J Dermatopathol
; 2010 Oct;32(7):683-7
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[Title]
Immunolabeling pattern of podoplanin (d2-40) may distinguish basal
cell
carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases.
When the
morphologic
distinction between basal
cell
carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two
neoplasms
from each other.
Their distinction is clinically important because the risk of progressive
disease
in BCC can be problematic, and trichoepitheliomas misinterpreted as BCC burdens the patient with an inaccurate diagnosis and consequential inappropriate surgery.
Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous
neoplasms
, such as adnexal
tumors
,
squamous cell
carcinomas, etc.
We studied the expression of D2-40 by immunohistochemistry to determine if this marker could reliably differentiate these
neoplasms
from each other.
A total of 49 cutaneous
tumors
, including 22 cases of trichoepitheliomas and 27 cases of BCC were examined.
This data suggests that D2-40 expression could be a useful potential marker to distinguish BCCs from trichoepitheliomas, especially when there is a high index of histologic suspicion for either of these two
tumors
.
[MeSH-major]
Biomarkers,
Tumor
/ analysis. Carcinoma, Basal
Cell
/ diagnosis. Membrane Glycoproteins / biosynthesis.
Neoplasms
, Basal
Cell
/ diagnosis. Skin
Neoplasms
/ diagnosis
[MeSH-minor]
Antibodies, Monoclonal. Antibodies, Monoclonal, Murine-Derived. Diagnosis, Differential. Humans. Immunohistochemistry. Predictive
Value
of Tests
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(PMID = 20559122.001).
[ISSN]
1533-0311
[Journal-full-title]
The American Journal of dermatopathology
[ISO-abbreviation]
Am J Dermatopathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40
40.
Fujishiro M, Yahagi N, Kakushima N, Kodashima S, Muraki Y, Ono S, Yamamichi N, Tateishi A, Shimizu Y, Oka M, Ogura K, Kawabe T, Ichinose M, Omata M:
Endoscopic submucosal dissection of esophageal squamous cell neoplasms.
Clin Gastroenterol Hepatol
; 2006 Jun;4(6):688-94
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[Title]
Endoscopic submucosal dissection of esophageal
squamous cell neoplasms
.
BACKGROUND & AIMS: Endoscopic submucosal dissection (ESD) has recently been developed for en bloc resection of stomach
neoplasms
, which results in high
tumor
eradication rates as well as a modality for the precise histologic assessment of the entire lesion.
Application of the technique is desirable for esophageal
squamous cell neoplasms
(SCNs), but there have been no reports on the use of this procedure in the esophagus.
METHODS: An ESD with methods similar to those used for resections of early gastric cancer was performed on 58 consecutive esophageal SCNs with preoperative diagnoses of intraepithelial
neoplasm
or intramucosal invasive carcinoma occurring in 43 enrolled patients.
RESULTS: The rate of en bloc resection was 100% (58/58), and en bloc resection with
tumor
-free lateral/basal margins (R0 resection) was 78% (45/58).
Of 40 lesions occurring in 31 patients fulfilling the criteria of node-negative
tumors
(mean follow-up, 17 months), 1 lesion resected by en bloc resection with nonevaluable
tumor
-free lateral margins (Rx [lateral] resection) recurred locally 6 months after ESD, which was treated successfully by a second ESD procedure.
[MeSH-major]
Esophageal
Neoplasms
/ surgery. Esophagoscopy.
Neoplasms
,
Squamous Cell
/ surgery
MedlinePlus Health Information.
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(PMID = 16713746.001).
[ISSN]
1542-3565
[Journal-full-title]
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
[ISO-abbreviation]
Clin. Gastroenterol. Hepatol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Coloring Agents; 9679TC07X4 / Iodine
41.
Fallai C, Bolner A, Signor M, Gava A, Franchin G, Ponticelli P, Taino R, Rossi F, Ardizzoia A, Oggionni M, Crispino S, Olmi P:
Long-term results of conventional radiotherapy versus accelerated hyperfractionated radiotherapy versus concomitant radiotherapy and chemotherapy in locoregionally advanced carcinoma of the oropharynx.
Tumori
; 2006 Jan-Feb;92(1):41-54
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AIMS AND BACKGROUND: To compare conventional fractionation (CF) radiation therapy (RT), arm A, versus a split-course accelerated hyperfractionated schedule (S-AHF), arm B, versus CFRT plus concomitant chemotherapy (CT), arm C, in terms of five-year survival and toxicity for
squamous cell
tumors
of the oropharynx.
Five-year second-
tumor
-free survival was 85%.
The 13 second
tumors
were equally distributed and were mainly correlated with tobacco and alcohol consumption (five lung, two esophagus, two oral cavity, one larynx, one pancreas, one hepatocarcinoma, one myeloma).
CONCLUSIONS: The results obtained with the combination of CT and RT compared with RT alone did
not
reach statistical significance, but combined treatment almost doubled the five-year overall survival, relapse-free survival and locoregional control rate.
Patients with advanced
squamous cell
carcinomas of the oropharynx who are medically suitable for the combined approach should be treated with a combination of radiotherapy and chemotherapy.
The occurrence of second
tumors
is relatively common in these patients and may contribute substantially to the causes of death.
[MeSH-major]
Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma,
Squamous Cell
/ drug therapy. Carcinoma,
Squamous Cell
/ radiotherapy. Oropharyngeal
Neoplasms
/ drug therapy. Oropharyngeal
Neoplasms
/ radiotherapy
[MeSH-minor]
Aged. Biomarkers,
Tumor
/ analysis. Carboplatin / administration & dosage. Chemotherapy, Adjuvant / adverse effects. Dose Fractionation. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged.
Neoplasm
Staging.
Neoplasms
, Second Primary / drug therapy.
Neoplasms
, Second Primary / radiotherapy. Radiotherapy, Adjuvant / adverse effects. Radiotherapy, Adjuvant / methods. Risk Factors. Salvage Therapy. Survival Analysis. Time Factors. Treatment Failure. Treatment Outcome
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(PMID = 16683383.001).
[ISSN]
0300-8916
[Journal-full-title]
Tumori
[ISO-abbreviation]
Tumori
[Language]
eng
[Publication-type]
Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil
42.
Kluger N, Minier-Thoumin C, Plantier F:
Keratoacanthoma occurring within the red dye of a tattoo.
J Cutan Pathol
; 2008 May;35(5):504-7
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Keratoacanthoma (KA) is a common keratinizing
squamous cell
neoplasm
of unknown origin characterized by rapid growth and spontaneous involution.
Lack of papillomatosis and viral inclusions ruled out the diagnosis of viral wart, absence of granulomatous reaction ruled out deep fungal or mycobacterial infection and lack of cytological atypia and frank architectural abnormalities did
not
favour a
squamous cell
carcinoma.
Diagnosis can be challenging as differential diagnoses include pseudoepitheliomatous hyperplasia and
squamous cell
carcinoma.
[MeSH-minor]
Adult. Carcinoma,
Squamous Cell
/ diagnosis. Diagnosis, Differential. Female. Histiocytes / pathology. Humans. Keratinocytes / pathology. Keratins / analysis. Lymphocytes / pathology. Skin
Neoplasms
/ diagnosis
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(PMID = 17976209.001).
[ISSN]
1600-0560
[Journal-full-title]
Journal of cutaneous pathology
[ISO-abbreviation]
J. Cutan. Pathol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Denmark
[Chemical-registry-number]
0 / Coloring Agents; 68238-35-7 / Keratins
43.
Shestakova T, Zhuravel E, Bolgova L, Alekseenko O, Soldatkina M, Pogrebnoy P:
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study.
Exp Oncol
; 2008 Jun;30(2):153-6
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[Title]
Expression of human beta-defensins-1, 2 and 4 mRNA in human lung
tumor
tissue: a pilot study.
AIM: To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human lung
tumors
.
MATERIALS AND METHODS: Tissue samples of surgically resected human lung
tumors
(
squamous cell
carcinoma (SCC), n=10; adenocarcinoma (AC), n=10) paired with conditionally normal tissue samples were analyzed for expression of hBD-1, 2, 4 mRNA by semiquantitative RT-PCR.
No correlation was detected between the levels of hBD-1, hBD-2 and hBD-4 mRNA and histological type, differentiation grade of the
tumor
, and the stage of the
disease
, as well as the content of hBD-2 peptide in blood serum of lung cancer patients.
CONCLUSION: Human beta-defensins-1 and -2 are often up-regulated in human lung
tumors
.
[MeSH-major]
Gene Expression Regulation, Neoplastic. Lung
Neoplasms
/ metabolism. Up-Regulation. beta-Defensins / biosynthesis
[MeSH-minor]
Cell
Line,
Tumor
. Cohort Studies. Humans. Pilot Projects. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tissue Distribution
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(PMID = 18566581.001).
[ISSN]
1812-9269
[Journal-full-title]
Experimental oncology
[ISO-abbreviation]
Exp. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Ukraine
[Chemical-registry-number]
0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / RNA, Messenger; 0 / beta-Defensins
44.
Jiang Y, Chen Y, Gao L, Ye Q, Alonso MA:
[Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx].
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 2009 May;23(10):451-3
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[Title]
[Expression pattern of MAL in normal epithelial cells, benign
tumor
, and
squamous cell
carcinoma of larynx].
METHOD: Use the immunohistochemical technique to analyze the distribution of MAL in normal laryngeal epithelial cells, polyp of vocal cords, laryngeal atypical hyperplasia and laryngeal
squamous cell
carcinoma.
Comparatively, MAL expression is significantly down regulated in laryngeal atypical hyperplasia and laryngeal
squamous cell
carcinomas (P < 0.05).
MAL, therefore, is a potential marker for early diagnosis of laryngeal
squamous cell
carcinoma.
[MeSH-major]
Carcinoma,
Squamous Cell
/ metabolism. Laryngeal Mucosa / metabolism. Laryngeal
Neoplasms
/ metabolism. Membrane Transport Proteins / metabolism. Myelin Proteins / metabolism. Proteolipids / metabolism
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(PMID = 19670627.001).
[ISSN]
1001-1781
[Journal-full-title]
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
[ISO-abbreviation]
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
[Language]
chi
[Publication-type]
English Abstract; Journal Article
[Publication-country]
China
[Chemical-registry-number]
0 / MAL protein, human; 0 / Membrane Transport Proteins; 0 / Myelin Proteins; 0 / Myelin and Lymphocyte-Associated Proteolipid Proteins; 0 / Proteolipids
45.
Gualberto A, Dolled-Filhart M, Gustavson M, Christiansen J, Wang YF, Hixon ML, Reynolds J, McDonald S, Ang A, Rimm DL, Langer CJ, Blakely J, Garland L, Paz-Ares LG, Karp DD, Lee AV:
Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition.
Clin Cancer Res
; 2010 Sep 15;16(18):4654-65
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[Title]
Molecular analysis of non-small
cell
lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition.
PURPOSE: This study aimed to identify molecular determinants of sensitivity of non-small
cell
lung cancer (NSCLC) to anti-insulin-like growth factor receptor (IGF-IR) therapy.
EXPERIMENTAL DESIGN: A total of 216
tumor
samples were investigated, of which 165 consisted of retrospective analyses of banked tissue and an additional 51 were from patients enrolled in a phase II study of figitumumab, a monoclonal antibody against IGF-IR, in stage IIIb/IV NSCLC.
RESULTS: IGF-IR was differentially expressed across histologic subtypes (P = 0.04), with highest levels observed in
squamous cell
tumors
.
Elevated IGF-IR expression was also observed in a small number of
squamous cell
tumors
responding to chemotherapy combined with figitumumab (P = 0.008).
Furthermore, a higher response rate to the combination of chemotherapy and figitumumab was observed in transitional
tumors
(71%) compared with those in the mesenchymal-like subset (32%; P = 0.03).
Only one epithelial-like
tumor
was identified in the phase II study, suggesting that advanced NSCLC has undergone significant dedifferentiation at diagnosis.
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[Copyright]
©2010 AACR.
[Cites]
Appl Immunohistochem Mol Morphol. 2009 Jul;17(4):329-37
[
19318915.001
]
[Cites]
Cancer Lett. 2009 Sep 8;282(1):14-24
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19153117.001
]
[RetractionIn]
Clin Cancer Res. 2014 Jun 15;20(12):3358
[
24928947.001
]
(PMID = 20670944.001).
[ISSN]
1078-0432
[Journal-full-title]
Clinical cancer research : an official journal of the American Association for Cancer Research
[ISO-abbreviation]
Clin. Cancer Res.
[Language]
ENG
[Grant]
United States / NIEHS NIH HHS / ES / R01 ES015704-04; United States / NCI NIH HHS / CA / P50CA58183; United States / NIEHS NIH HHS / ES / R01 ES015704; United States / NIEHS NIH HHS / ES / ES015704; United States / NCI NIH HHS / CA / P50 CA058183; United States / NCI NIH HHS / CA / R01 CA094118
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Retracted Publication; Validation Studies
[Publication-country]
United States
[Chemical-registry-number]
0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Hormone Antagonists; 0 / Immunoglobulins, Intravenous; 67763-96-6 / Insulin-Like Growth Factor I; VE267FC2UB / figitumumab
[Other-IDs]
NLM/ NIHMS226076; NLM/ PMC2952544
46.
Rodrigo JP, Cabanillas R, Chiara MD, García Pedrero J, Florentino Fresno M, Suárez Nieto C:
[Molecular alterations in nodal metastases and its primary tumors in squamous cell carcinomas of the larynx].
Acta Otorrinolaringol Esp
; 2008 Mar;59(3):114-9
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[Title]
[Molecular alterations in nodal metastases and its primary
tumors
in
squamous cell
carcinomas of the larynx].
[Transliterated title]
Alteraciones moleculares en las metástasis ganglionares y sus tumores primarios en los carcinomas epidermoides
de
laringe.
INTRODUCTION AND OBJECTIVES: The successive acquisition of molecular alterations determines
tumour
progression.
During this progression, the development of nodal metastases is one of the most important prognostic factors in laryngeal
squamous cell
carcinomas.
The aim of this study is to analyze if, in these carcinomas, the molecular alterations in the nodal metastases are different from those present in the primary
tumour
.
MATERIAL AND METHOD: Paired samples of primary
tumour
and nodal metastases from 51 patients with
squamous cell
carcinoma of the supraglottic larynx were studied.
RESULTS: A close correlation in the expression of the proteins studied was observed in the nodal metastases and the corresponding primary
tumour
, with the exception of HIF-1a expression and the degree of vascularization.
CONCLUSIONS: Most of the molecular alterations in the nodal metastases are already present in the primary
tumour
, suggesting that these alterations are early events in carcinogenesis.
[MeSH-major]
Carcinoma,
Squamous Cell
/ secondary. Laryngeal
Neoplasms
/ pathology
[MeSH-minor]
Humans. Immunohistochemistry. Lymphatic Metastasis.
Neoplasm
Proteins / biosynthesis
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(PMID = 18364203.001).
[ISSN]
0001-6519
[Journal-full-title]
Acta otorrinolaringológica española
[ISO-abbreviation]
Acta Otorrinolaringol Esp
[Language]
spa
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Spain
[Chemical-registry-number]
0 / Neoplasm Proteins
47.
Kitcher E, Yarney J, Gyasi R, Cheyuo C:
Laryngeal cancer at the korle bu teaching hospital accra ghana.
Ghana Med J
; 2006 Jun;40(2):45-9
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The aim of this study was to determine the number of cases of laryngeal cancer seen at the Korle Bu Teaching Hospital, establish epidemiological parameters of the
disease
and to outline preventive measures.
METHOD: One hundred and fifteen (115) patients who were managed for laryngeal cancer from 1(st) January 1998 to 31(st) December 2003 were studied retrospectively with respect to age, sex, duration of symptoms at presentation, risk factors, symptoms complex, histopathology, stage of
tumor
, details of treatment offered and follow up.
A significant proportion of cases (37.3%) presented with locally advanced
disease
.
The commonest histological type of laryngeal
tumour
seen was
squamous cell
carcinoma.
Only 58 (69.9%) patients completed radiotherapy treatment and in all 32 (24.3 %) patients did
not
report for any treatment.
CONCLUSIONS: We conclude that significant number of patients with laryngeal cancer presented with locally advanced
disease
and dysphonia was the commonest symptom.
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[Cites]
Laryngoscope. 1975 Jul;85(7):1190-6
[
1152568.001
]
[Cites]
Int J Radiat Oncol Biol Phys. 1991 Jan;20(1):21-8
[
1993628.001
]
[Cites]
Am J Surg. 1991 Oct;162(4):337-40
[
1951884.001
]
(PMID = 17299565.001).
[ISSN]
0016-9560
[Journal-full-title]
Ghana medical journal
[ISO-abbreviation]
Ghana Med J
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Ghana
[Other-IDs]
NLM/ PMC1790844
48.
Nishimura G, Horiuchi C, Yoshida T, Kawakami M, Yabuki K, Matsuda H, Mikami Y, Tsukuda M:
Fibromatous polyp of the hypopharynx.
Auris Nasus Larynx
; 2006 Sep;33(3):333-6
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We treated a patient with hypopharyngeal fibromatous polyp and speculated the mechanism of this
disease
.
The greater part of hypopharyngeal
tumors
is
squamous cell
carcinomas, and benign
tumors
are really uncommon.
Fibromatous polyp is
not
thought to be a true
tumor
, but the symptoms are almost the same as tumorous diseases, e.g., discomfort in the throat, swallowing difficulty and respiratory distress.
[MeSH-major]
Hypopharyngeal
Neoplasms
/ diagnosis. Polyps / diagnosis
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(PMID = 16504437.001).
[ISSN]
0385-8146
[Journal-full-title]
Auris, nasus, larynx
[ISO-abbreviation]
Auris Nasus Larynx
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Netherlands
49.
Cai T, Nesi G, Boddi V, Mazzoli S, Dal Canto M, Bartoletti R:
Prognostic role of the tumor-associated tissue inflammatory reaction in transitional bladder cell carcinoma.
Oncol Rep
; 2006 Aug;16(2):329-34
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[Title]
Prognostic role of the
tumor
-associated tissue inflammatory reaction in transitional bladder
cell
carcinoma.
Many authors have indicated that the presence of an inflammatory response within the
tumor
may predict
not
only recurrence and progression but also survival in several
tumors
, including transitional
cell
carcinoma (TCC) of the urinary bladder.
The aim of the present study was to define the influence of inflammatory
cell
infiltrate on recurrence, progression and survival in TCC of the bladder over a long follow-up period.
Between January and December 1995, 410 consecutive patients, who had undergone transurethral or open surgery for bladder
tumors
at the same urologic center, were selected for the study.
All cases were reviewed to assess histotype, stage and grade of the
tumor
and presence or absence of
tumor
-associated inflammatory reaction.
Pathologic evaluation showed superficial TCC in 312 patients, while 98 had an invasive bladder
tumor
.
Three among 410 bladder
tumors
were
squamous cell
carcinomas.
Out of 407 TCCs, 119 (29.23%) presented inflammation within the
tumor
or the lamina propria.
At 10 years follow-up, a statistically significant association was shown between the presence of inflammation within the
tumor
or lamina propria and the number of recurrences (p<0.0001).
Moreover, the absence of inflammatory infiltrate in the
tumor
established the relative risk of suffering more than one recurrence at 2.287 (95% CI 1.180-3.346).
The Mann-Whitney test confirmed a statistically significant difference between superficial bladder
tumors
with inflammation and those without (26.3 vs 11.5 months, p<0.001).
On multivariate analysis, the presence of inflammation within the
tumor
was found to be an independent predictor of survival in patients with TCC of the bladder (p=0.027).
Survival analysis by means of the Kaplan-Meier curves showed a statistically significant difference between patients with
tumor
-associated inflammatory reaction and those without (p=0.0098).
These results confirm that the presence of inflammatory reaction has a good prognostic
value
in transitional bladder
cell
carcinoma.
However, to better define its prognostic significance, the characterization of inflammatory cells in
tumor
-associated tissue reaction must be accomplished.
[MeSH-major]
Carcinoma, Transitional
Cell
/ mortality. Carcinoma, Transitional
Cell
/ pathology. Urinary Bladder
Neoplasms
/ mortality. Urinary Bladder
Neoplasms
/ pathology
[MeSH-minor]
Adult. Aged.
Disease
Progression. Female. Humans. Inflammation / diagnosis. Inflammation / pathology. Male. Middle Aged.
Neoplasm
Recurrence, Local / diagnosis.
Neoplasm
Recurrence, Local / mortality.
Neoplasm
Recurrence, Local / pathology.
Neoplasm
Staging. Prognosis
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(PMID = 16820911.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Greece
50.
Au JT, Sugiyama G, Wang H, Nicastri A, Lee D, Ko W, Tak V:
Carcinosarcoma of the oesophagus - a rare mixed type of tumor.
J Surg Case Rep
; 2010;2010(7):7
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[Title]
Carcinosarcoma of the oesophagus - a rare mixed type of
tumor
.
Oesophageal carcinosarcoma is a rare type of oesophageal cancer composed of both
squamous
cells and sarcomatous cells.
On surgical pathology, it was discovered that the
tumor
had both
squamous cell
and sarcomatous
cell
components, and the final diagnosis was changed to oesophageal carcinosarcoma.
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[Copyright]
© JSCR.
(PMID = 24946341.001).
[ISSN]
2042-8812
[Journal-full-title]
Journal of surgical case reports
[ISO-abbreviation]
J Surg Case Rep
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
[Other-IDs]
NLM/ PMC3649142
51.
Wang L, Chang X, Yuan G, Zhao Y, Wang P:
Expression of peptidylarginine deiminase type 4 in ovarian tumors.
Int J Biol Sci
; 2010;6(5):454-64
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[Title]
Expression of peptidylarginine deiminase type 4 in ovarian
tumors
.
The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in SKOV-3 cells that originated from ovary
tumors
.
We utilized immunohistochemistry, real-time PCR and western blotting to analyze the expression of PADI4 in the
tumor
tissues and in the
cell
line that were cultured with estrodial-17β.
PADI4 was detected in serious cystadenocarcinoma (n=39, positivity=100%), clear
cell
cancer (n=7, positivity= 100%), mucinous cystadenocarcinoma (n=6, positivity=100%), dysgerminoma (n=6, positivity=100%),
squamous cell
tumor
(n=6, positivity=100%), sibnet-ring
cell
carcinoma (n=6, positivity=100%), endodermal sinus
tumor
(n=6, positivity=100%), germ
cell
tumors
(n=6, positivity=100%) and immature teratoma (n=6, positivity=100%).
However, PADI4 was either
not
detected or detected at low levels in granulosa
cell
tumor
(n=6), malignant thecoma (n=6), ovarian cystadenoma (n=5) and normal ovarian tissue (n=11).
PADI4 was evenly distributed in the cytoplasm of
tumor
cells of serious cystadenocarcinoma that were classified as being grade II and III by histopathological scoring.
However, PADI4 showed granular cellular distribution in the
tumor
tissues that were isolated from grade I cystadenocarcinoma.
[MeSH-major]
Hydrolases / metabolism. Ovarian
Neoplasms
/ enzymology
[MeSH-minor]
Blotting, Western.
Cell
Line,
Tumor
. Estradiol / pharmacology. Estradiol / physiology. Female. Gene Expression / drug effects. Humans. Immunohistochemistry. Polymerase Chain Reaction. RNA, Messenger / metabolism
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Int Immunol. 1998 Dec;10(12):1891-5
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9885910.001
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Clin Endocrinol (Oxf). 1998 Dec;49(6):695-707
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Rheumatology (Oxford). 2005 Jan;44(1):40-50
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Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10746-50
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(PMID = 20827398.001).
[ISSN]
1449-2288
[Journal-full-title]
International journal of biological sciences
[ISO-abbreviation]
Int. J. Biol. Sci.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Australia
[Chemical-registry-number]
0 / RNA, Messenger; 4TI98Z838E / Estradiol; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase type IV
[Other-IDs]
NLM/ PMC2935668
[Keywords]
NOTNLM ; Peptidylarginine deiminase type 4 (PADI4/PAD4) / estrodial-17β. / ovarian cancer (OCa)
52.
Hainsworth JD, Fizazi K:
Treatment for patients with unknown primary cancer and favorable prognostic factors.
Semin Oncol
; 2009 Feb;36(1):44-51
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Specific subsets include women with peritoneal carcinomatosis, women with isolated axillary lymph node metastases, adenocarcinoma presenting as a single metastatic lesion, young men with features of extragonadal germ
cell
tumor
,
squamous
carcinoma involving cervical or inguinal lymph nodes, and neuroendocrine carcinoma.
[MeSH-major]
Neoplasms
, Unknown Primary / therapy
[MeSH-minor]
Biomarkers,
Tumor
/ analysis. Humans. Prognosis
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(PMID = 19179187.001).
[ISSN]
0093-7754
[Journal-full-title]
Seminars in oncology
[ISO-abbreviation]
Semin. Oncol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor
[Number-of-references]
58
53.
Vilen ST, Nyberg P, Hukkanen M, Sutinen M, Ylipalosaari M, Bjartell A, Paju A, Haaparanta V, Stenman UH, Sorsa T, Salo T:
Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma.
Exp Cell Res
; 2008 Feb 15;314(4):914-26
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Tumor
-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive
squamous cell
carcinomas.
We describe here that oral
squamous cell
carcinomas express all members of this cascade: MMP-9, trypsin-2 and enterokinase.
The expression of enterokinase in a carcinoma
cell
line
not
derived from the duodenum was shown here for the first time.
However, although both proteases were present also in various bone
tumor
tissues, MMP-9 and trypsin-2 never co-localized at the cellular level in these tissues.
This suggests that the intracellular vesicular co-localization, storage and possible activation of these proteases may be a unique feature for aggressive epithelial
tumors
, such as
squamous cell
carcinomas, but
not
for
tumors
of mesenchymal origin.
[MeSH-major]
Carcinoma,
Squamous Cell
/ enzymology. Enteropeptidase / metabolism. Matrix Metalloproteinase 9 / metabolism. Mouth
Neoplasms
/ enzymology. Trypsin / metabolism. Trypsinogen / metabolism
[MeSH-minor]
Bone
Neoplasms
/ enzymology. Carcinoma / enzymology.
Cell
Line,
Tumor
. Enzyme Precursors / metabolism. Humans
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(PMID = 18062964.001).
[ISSN]
0014-4827
[Journal-full-title]
Experimental cell research
[ISO-abbreviation]
Exp. Cell Res.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Enzyme Precursors; 103964-84-7 / PRSS2 protein, human; 9002-08-8 / Trypsinogen; EC 3.4.21.4 / Trypsin; EC 3.4.21.9 / Enteropeptidase; EC 3.4.24.- / pro-matrix metalloproteinase 9; EC 3.4.24.35 / Matrix Metalloproteinase 9
54.
Candelaria M, Arias-Bonfill D, Chávez-Blanco A, Chanona J, Cantú D, Pérez C, Dueñas-González A:
Lack in efficacy for imatinib mesylate as second-line treatment of recurrent or metastatic cervical cancer expressing platelet-derived growth factor receptor alpha.
Int J Gynecol Cancer
; 2009 Dec;19(9):1632-7
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The median age was 49.8 years; all but 1
tumor
were
squamous cell
carcinomas.
Ten (83.3%) had pelvic and systemic
disease
, whereas only 2 had systemic
disease
alone.
A single patient having metastatic
disease
in the lung showed stabilization for 6 months to then progressing in bone.
Despite lack of activity of single-agent imatinib, further studies in cervical cancer are deserved to better define the status of imatinib targets in this
tumor
and to investigate its activity in combination with cytotoxic drugs.
[MeSH-major]
Carcinoma,
Squamous Cell
/ drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Uterine Cervical
Neoplasms
/ drug therapy
[MeSH-minor]
Adult. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Benzamides. Chemotherapy, Adjuvant. Female. Humans. Imatinib Mesylate. Middle Aged.
Neoplasm
Metastasis. Recurrence. Survival Analysis. Treatment Outcome
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(PMID = 19955950.001).
[ISSN]
1525-1438
[Journal-full-title]
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
[ISO-abbreviation]
Int. J. Gynecol. Cancer
[Language]
eng
[Publication-type]
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha
55.
Orrock JM, Abbott JJ, Gibson LE, Folpe AL:
INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimics.
Am J Dermatopathol
; 2009 Apr;31(2):152-6
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The morphological features of epithelioid sarcoma may closely mimic those of epithelial
neoplasms
, such as
squamous cell
carcinoma, mesenchymal
tumors
, such as benign fibrous histiocytoma, and nonneoplastic lesions, such as granuloma annulare.
Recently, loss of expression of INI1,
a tumor
suppressor gene/protein, and expression of GLUT-1, a glucose transporter protein, have been described in epithelioid sarcoma.
Twenty-four cases of epithelioid sarcoma, 13 cases of granuloma annulare, 10 cases of rheumatoid nodule, 19 cases of cutaneous
squamous cell
carcinoma, 7 cases of atypical fibroxanthoma, 9 cases of benign fibrous histiocytoma (dermatofibroma), and 3 cases of nodular fasciitis were immunostained for GLUT-1 and INI1 using commercially available antibodies, heat-induced epitope retrieval, and the Dako Envision detection system.
GLUT-1 was positive in 40%-50% of epithelioid sarcomas, all cases of granuloma annulare and rheumatoid nodules, 67% of benign fibrous histiocytomas, and in all
squamous cell
carcinomas.
In this clinical context, loss of INI1 expression seems to be an entirely specific marker of epithelioid sarcoma and this
finding
may be of great
value
in distinguishing CD34-negative epithelioid sarcoma from
squamous cell
carcinoma and in the distinction of rare cytokeratin-negative epithelioid sarcomas from necrobiotic processes, nodular fasciitis, and benign fibrous histiocytomas.
In contrast, there does
not
seem to be a role for GLUT-1 immunohistochemistry in this differential diagnosis.
[MeSH-major]
Chromosomal Proteins, Non-Histone / metabolism. DNA-Binding Proteins / metabolism. Glucose Transporter Type 1 / metabolism. Granuloma Annulare / metabolism. Sarcoma / metabolism. Skin Diseases / metabolism. Skin
Neoplasms
/ metabolism. Transcription Factors / metabolism
[MeSH-minor]
Biomarkers / metabolism. Diagnosis, Differential. Fasciitis / metabolism. Fasciitis / pathology. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Humans.
Neoplasms
,
Squamous Cell
/ metabolism.
Neoplasms
,
Squamous Cell
/ pathology. Rheumatoid Nodule / metabolism. Rheumatoid Nodule / pathology. Xanthomatosis / metabolism. Xanthomatosis / pathology
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(PMID = 19318800.001).
[ISSN]
1533-0311
[Journal-full-title]
The American Journal of dermatopathology
[ISO-abbreviation]
Am J Dermatopathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Glucose Transporter Type 1; 0 / SMARCB1 protein, human; 0 / Transcription Factors
56.
Wyatt RM, Jones BJ, Dale RG:
Radiotherapy treatment delays and their influence on tumour control achieved by various fractionation schedules.
Br J Radiol
; 2008 Jul;81(967):549-63
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[Title]
Radiotherapy treatment delays and their influence on
tumour
control achieved by various fractionation schedules.
There is often a considerable delay from initial
tumour
diagnosis to the start of radiotherapy treatment.
This paper extends the calculations of a previous paper on the effects of delays before the initiation of radiotherapy treatment to include results from a variety of practical fractionation regimes for three different types of
tumour
:
squamous cell
carcinoma (head and neck), breast and prostate.
The linear quadratic model of radiation effect, logarithmic
tumour
growth (coupled with delay times where relevant) and the Poisson model for
tumour
control probability (TCP) are used to calculate the change in TCP for delays between diagnosis and treatment.
The results show that delays in the start of radiotherapy treatment do have an adverse effect on
tumour
control for fast-growing tumours.
For example, calculations predict a reduction in local
tumour
control of up to 1.5% per week's delay for head and neck cancers treated following surgery.
In addition, there may be a variety of fractionation regimes that will yield very similar clinical results for each
tumour
type.
It is shown theoretically that, for the
tumour
types considered here, it is possible to increase the dose per fraction and decrease the number of fractions while maintaining or increasing TCP relative to standard 2 Gy fractionation regimes, although there may be some advantage to using hyperfractionated regimes for head and neck cancers in order to reduce normal tissue effects.
[MeSH-major]
Breast
Neoplasms
/ radiotherapy. Head and Neck
Neoplasms
/ radiotherapy. Prostatic
Neoplasms
/ radiotherapy
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(PMID = 18378526.001).
[ISSN]
1748-880X
[Journal-full-title]
The British journal of radiology
[ISO-abbreviation]
Br J Radiol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
57.
Hong JH, Yang YM, Kim HS, Lee SI, Muallem S, Shin DM:
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes.
Prog Biophys Mol Biol
; 2010 Sep;103(1):81-7
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[Title]
Markers of
squamous cell
carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes.
A mutation of Atp2a2 gene encoding the sarco/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) causes Darier's
disease
in human and null mutation in one copy of Atp2a2 leads to a high incidence of
squamous cell
tumor
in a mouse model.
In SERCA2 heterozygote (SERCA2(+/-)) mice keratinocytes, mechanisms involved in partial depletion of SERCA2 gene and its related
tumor
induction have
not
been studied.
Using the gene fishing system, we first found in SERCA2(+/-) keratinocytes that gene level of
tumor
-associated calcium signal transducer 1, crystalline alphaB, procollagen XVIII alpha1, and nuclear factor I-B were increased.
These results suggest that the alterations of Ca(2+) signaling by SERCA2 haploinsufficiency alternate the gene expression of
tumor
induction and differentiation in keratinocytes.
[MeSH-major]
Carcinoma,
Squamous Cell
/ metabolism. Heterozygote. Keratinocytes / metabolism. Sarcoplasmic Reticulum Calcium-Transporting ATPases / genetics. Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism
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.
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.
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.
NCI CPTAC Assay Portal.
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.
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[Copyright]
Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.
(PMID = 19840814.001).
[ISSN]
1873-1732
[Journal-full-title]
Progress in biophysics and molecular biology
[ISO-abbreviation]
Prog. Biophys. Mol. Biol.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't; Review
[Publication-country]
England
[Chemical-registry-number]
0 / Biomarkers; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases
58.
Das M, Ansari KM, Dhawan A, Shukla Y, Khanna SK:
Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice.
Int J Cancer
; 2005 Dec 10;117(5):709-17
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Single topical application of AO (0.15-0.3 ml) or isolated sanguinarine (4.5-18 micromol) followed by twice-weekly application of tetradecanoylphorbolmyristate acetate (TPA) for 25 weeks resulted in formation of
tumors
.
Histopathologically these
tumors
were of
squamous cell
carcinoma type and similar to those found in the positive control group using dimethylbenzanthracene (DMBA)/TPA.
Although the genotoxic lesions may be repaired to some extent on withdrawal of consumption of AO contaminated mustard oil and the residual genotoxic effects caused by AO may
not
be expressed as signs of carcinogenesis.
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[Copyright]
Copyright 2005 Wiley-Liss, Inc
(PMID = 15981203.001).
[ISSN]
0020-7136
[Journal-full-title]
International journal of cancer
[ISO-abbreviation]
Int. J. Cancer
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
0 / Alkaloids; 0 / Benzophenanthridines; 0 / Carcinogens; 0 / Isoquinolines; 0 / Plant Oils; 0 / argemone oil; AV9VK043SS / sanguinarine
59.
Kada S, Hirano S, Tateya I, Kitamura M, Ishikawa S, Kanda T, Asato R, Tanaka S, Ito J:
Ten years single institutional experience of treatment for advanced laryngeal cancer in Kyoto University.
Acta Otolaryngol Suppl
; 2010 Nov;(563):68-73
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All
tumors
were
squamous cell
carcinoma, arising at the glottis in 21 cases and the supraglottis in 12 cases.
Five-year
disease
-specific survival rates for stage III of glottic cancer, stage IV of glottic cancer, stage III of supraglottic cancer, and stage IV of supraglottic cancer were 100%, 56.3%, 100%, and 28.1%, respectively.
Both of them died of
disease
despite undergoing chemotherapy.
[MeSH-major]
Carcinoma,
Squamous Cell
/ pathology. Carcinoma,
Squamous Cell
/ therapy. Laryngeal
Neoplasms
/ pathology. Laryngeal
Neoplasms
/ therapy
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(PMID = 20879822.001).
[ISSN]
0365-5237
[Journal-full-title]
Acta oto-laryngologica. Supplementum
[ISO-abbreviation]
Acta Otolaryngol Suppl
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
England
60.
Abel EL, Angel JM, Kiguchi K, DiGiovanni J:
Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications.
Nat Protoc
; 2009;4(9):1350-62
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For more than 60 years, the chemical induction of
tumors
in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors.
Subsequently,
tumor
development is elicited by repeated treatment with
a tumor
-promoting agent.
The initiation protocol can be completed within 1-3 h depending on the number of mice used; whereas the promotion phase requires twice weekly treatments (1-2 h) and once weekly
tumor
palpation (1-2 h) for the duration of the study.
Using the protocol described here, a highly reproducible papilloma burden is expected within 10-20 weeks with progression of a portion of the
tumors
to
squamous cell
carcinomas within 20-50 weeks.
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(PMID = 19713956.001).
[ISSN]
1750-2799
[Journal-full-title]
Nature protocols
[ISO-abbreviation]
Nat Protoc
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA076520; United States / NCI NIH HHS / CA / P30 CA016672; United States / NIEHS NIH HHS / ES / ES007784; United States / NCI NIH HHS / CA / R01 CA037111; United States / NCI NIH HHS / CA / CA016672; United States / NIEHS NIH HHS / ES / R01 ES016623; United States / NIEHS NIH HHS / ES / ES015718; United States / NIEHS NIH HHS / ES / P30 ES007784; United States / NIEHS NIH HHS / ES / R01 ES016623-02; United States / NIEHS NIH HHS / ES / ES016623; United States / NCI NIH HHS / CA / CA37111; United States / NCI NIH HHS / CA / R01 CA076520
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
England
[Chemical-registry-number]
0 / Carcinogens
[Other-IDs]
NLM/ NIHMS334643; NLM/ PMC3213400
61.
Clayton AC, Bentz JS, Wasserman PG, Schwartz MR, Souers RJ, Chmara BA, Laucirica R, Clary KM, Moriarty AT, College of American Pathologists Cytopathology Resource Committee:
Comparison of ThinPrep preparations to other preparation types in gastrointestinal cytology: observations from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology.
Arch Pathol Lab Med
; 2010 Aug;134(8):1116-20
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DESIGN: Participant responses between 2000 and 2007 were evaluated for esophageal wash/brush, gastric wash/brush, and biliary tract brush specimens with a reference diagnosis of adenocarcinoma,
squamous cell
carcinoma, carcinoid, or spindle
cell
neoplasm
.
Overall performance of cytotechnologists was
not
different from that of pathologists (89.2% versus 89.0%; P = .75).
Cytotechnologists had better performance for detecting
squamous cell
carcinoma (96.3% versus 92.6%; P < .001), while pathologists had better performance for detecting spindle
cell
neoplasm
(79.7% versus 42.9%; P < .001).
Cytotechnologists and pathologists performed at the same level overall, but with differences for the diagnosis of spindle
cell
neoplasm
and
squamous
carcinoma.
[MeSH-major]
Adenocarcinoma / diagnosis. Carcinoma,
Squamous Cell
/ diagnosis. Gastrointestinal
Neoplasms
/ diagnosis. Laboratories, Hospital / standards. Pathology, Clinical / methods
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(PMID = 20670130.001).
[ISSN]
1543-2165
[Journal-full-title]
Archives of pathology & laboratory medicine
[ISO-abbreviation]
Arch. Pathol. Lab. Med.
[Language]
eng
[Publication-type]
Comparative Study; Journal Article
[Publication-country]
United States
62.
Koike R, Nishimura Y, Nakamatsu K, Kanamori S, Shibata T:
Concurrent chemoradiotherapy for esophageal cancer with malignant fistula.
Int J Radiat Oncol Biol Phys
; 2008 Apr 1;70(5):1418-22
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There were 9 patients with Stage III
disease
and 7 with Stage IV
disease
.
All
tumors
were
squamous cell
carcinomas.
[MeSH-major]
Carcinoma,
Squamous Cell
/ drug therapy. Carcinoma,
Squamous Cell
/ radiotherapy. Esophageal Fistula / drug therapy. Esophageal Fistula / radiotherapy. Esophageal
Neoplasms
/ drug therapy. Esophageal
Neoplasms
/ radiotherapy
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(PMID = 18234437.001).
[ISSN]
0360-3016
[Journal-full-title]
International journal of radiation oncology, biology, physics
[ISO-abbreviation]
Int. J. Radiat. Oncol. Biol. Phys.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
United States
[Chemical-registry-number]
Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
63.
Stewart DJ:
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer.
Crit Rev Oncol Hematol
; 2010 Sep;75(3):173-234
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[Title]
Tumor
and host factors that may limit efficacy of chemotherapy in non-small
cell
and small
cell
lung cancer.
While chemotherapy provides useful palliation, advanced lung cancer remains incurable since those
tumors
that are initially sensitive to therapy rapidly develop acquired resistance.
Resistance may arise from impaired drug delivery, extracellular factors, decreased drug uptake into
tumor
cells, increased drug efflux, drug inactivation by detoxifying factors, decreased drug activation or binding to target, altered target, increased damage repair, tolerance of damage, decreased proapoptotic factors, increased antiapoptotic factors, or altered
cell
cycling or transcription factors.
Factors for which there is now substantial clinical evidence of a link to small
cell
lung cancer (SCLC) resistance to chemotherapy include MRP (for platinum-based combination chemotherapy) and MDR1/P-gp (for non-platinum agents).
In non-small
cell
lung cancer (NSCLC), the strongest clinical evidence is for taxane resistance with elevated expression or mutation of class III beta-tubulin (and possibly alpha tubulin), platinum resistance and expression of ERCC1 or BCRP, gemcitabine resistance and RRM1 expression, and resistance to several agents and COX-2 expression (although COX-2 inhibitors have had minimal impact on drug efficacy clinically).
Tumors
expressing high BRCA1 may have increased resistance to platinums but increased sensitivity to taxanes.
Limited early clinical data suggest that chemotherapy resistance in NSCLC may also be increased with decreased expression of cyclin B1 or of Eg5, or with increased expression of ICAM, matrilysin, osteopontin, DDH, survivin, PCDGF, caveolin-1, p21WAF1/CIP1, or 14-3-3sigma, and that IGF-1R inhibitors may increase efficacy of chemotherapy, particularly in
squamous cell
carcinomas.
Equivocal data (with some positive studies but other negative studies) suggest that NSCLC
tumors
with some EGFR mutations may have increased sensitivity to chemotherapy, while K-ras mutations and expression of GST-pi, RB or p27kip1 may possibly confer resistance.
To date, resistance-modulating strategies have generally
not
proven clinically useful in lung cancer, although small randomized trials suggest a modest benefit of verapamil and related agents in NSCLC.
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[Copyright]
Published by Elsevier Ireland Ltd.
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(PMID = 20047843.001).
[ISSN]
1879-0461
[Journal-full-title]
Critical reviews in oncology/hematology
[ISO-abbreviation]
Crit. Rev. Oncol. Hematol.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / CA016672-32; United States / NCI NIH HHS / CA / P30 CA016672; United States / NCI NIH HHS / CA / 5-P30 CA16672-32; United States / NCI NIH HHS / CA / P30 CA016672-32
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
[Publication-country]
Netherlands
[Chemical-registry-number]
0 / Antineoplastic Agents
[Other-IDs]
NLM/ NIHMS168520; NLM/ PMC2888634
64.
Razek AA:
Diffusion-weighted magnetic resonance imaging of head and neck.
J Comput Assist Tomogr
; 2010 Nov-Dec;34(6):808-15
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Diffusion-weighted magnetic resonance imaging plays a role in the differentiation of benign from malignant head and neck
tumors
,
squamous cell
carcinoma from lymphoma, and metastatic from benign lymphadenopathy as well as in the selection of the biopsy site.
It can be used for the differentiation of recurrent
tumors
from posttreatment changes and in monitoring the patient after radiotherapy.
It helps in the differentiation of necrotic
tumors
from abscesses.
[MeSH-major]
Diffusion Magnetic Resonance Imaging / methods. Head and Neck
Neoplasms
/ diagnosis
[MeSH-minor]
Biopsy. Diagnosis, Differential. Echo-Planar Imaging. Humans. Image Enhancement / methods. Lymphatic Metastasis.
Neoplasm
Recurrence, Local / diagnosis.
Neoplasm
Staging
MedlinePlus Health Information.
consumer health - Head and Neck Cancer
.
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(PMID = 21084893.001).
[ISSN]
1532-3145
[Journal-full-title]
Journal of computer assisted tomography
[ISO-abbreviation]
J Comput Assist Tomogr
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
United States
65.
National Toxicology Program:
Photocarcinogenesis study of aloe vera [CAS NO. 481-72-1(Aloe-emodin)] in SKH-1 mice (simulated solar light and topical application study).
Natl Toxicol Program Tech Rep Ser
; 2010 Sep;(553):7-33, 35-97, 99-103 passim
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Mice that received no cream treatment and were exposed to increasing levels of SSL showed significant SSL exposure-dependent decreases in survival and significant increases in the in-life observations of skin lesion onset, incidence, and multiplicity, and significant SSL exposure-dependent increases in the incidences and multiplicities of histopathology-determined
squamous cell
nonneoplastic skin lesions (
squamous
hyperplasia and focal atypical hyperplasia) and
squamous cell neoplasms
(papilloma, carcinoma in situ, and/or carcinoma).
Squamous cell neoplasms
were
not
detected in mice that received no SSL exposure.
The topical treatment with the control cream of mice that were exposed to SSL did
not
impart a measurable effect when compared with comparable measurements in mice that received no cream treatment and were exposed to the same level of SSL, suggesting that the control cream used in these studies did
not
alter the efficiency of the SSL delivered to mice or the tolerability of mice to SSL.
The administration of aloe gel creams to male mice had no effect on the incidences or multiplicities of histopathology-determined
squamous cell
nonneoplastic skin lesions or
neoplasms
.
Female mice treated with aloe gel creams (3% and 6%) had significantly increased multiplicities of
squamous cell neoplasms
.
In male mice exposed to SSL and treated with the 6% whole leaf cream, a significant increase was observed in the multiplicity of
squamous cell neoplasms
.
Female mice exposed to SSL and treated with the 3% whole leaf creams had significantly decreased multiplicity of
squamous cell
nonneoplastic lesions and significantly increased multiplicity of
squamous cell neoplasms
.
Female mice exposed to SSL and treated with the 6% whole leaf cream had significantly decreased multiplicity of
squamous cell
nonneoplastic lesions.
Male mice administered the 3% decolorized whole leaf cream had significantly increased multiplicity of
squamous cell neoplasms
.
Female mice administered the 3% decolorized whole leaf cream had significantly decreased multiplicity of
squamous cell
nonneoplastic skin lesions and significantly increased multiplicity of
squamous cell neoplasms
.
In female mice that received the 6% decolorized whole leaf cream, there was a significant increase in the multiplicity of
squamous cell neoplasms
.
The administration of aloe-emodin creams to male mice had no effect on the incidence or multiplicity of histopathology-determined nonneoplastic skin lesions or
squamous cell neoplasms
.
Female mice treated with the 74.6 µg/g aloe-emodin cream had significantly decreased multiplicity of histopathology-determined
squamous cell
nonneoplastic skin lesions and significantly increased multiplicity of
squamous cell neoplasms
.
ALOE GEL OR ALOE-EMODIN: under the conditions of these studies, there was a weak enhancing effect of aloe gel or aloe-emodin on the photocarcinogenic activity of SSL in female but
not
in male SKH-1 mice based on an increase in the multiplicity of histopathologically-determined
squamous cell neoplasms
.
ALOE WHOLE LEAF OR DECOLORIZED WHOLE LEAF: under the conditions of these studies, there was a weak enhancing effect of aloe whole leaf or decolorized whole leaf on the photocarcinogenic activity of SSL in both male and female SKH-1 mice based on an increase in the multiplicity of histopathologically-determined
squamous cell neoplasms
.
[MeSH-major]
Aloe / toxicity. Plant Extracts / toxicity. Skin
Neoplasms
/ etiology. Sunlight / adverse effects
MedlinePlus Health Information.
consumer health - Skin Cancer
.
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(PMID = 21031007.001).
[ISSN]
0888-8051
[Journal-full-title]
National Toxicology Program technical report series
[ISO-abbreviation]
Natl Toxicol Program Tech Rep Ser
[Language]
eng
[Publication-type]
Journal Article; Technical Report
[Publication-country]
United States
[Chemical-registry-number]
0 / Plant Extracts
66.
Srivastava A, Ghosh A, Saha S, Saha VP, Chakraborty D:
Sarcomas of head and neck - A 10 yrs experience.
Indian J Otolaryngol Head Neck Surg
; 2007 Dec;59(4):322-6
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Compared to other types of head and neck
neoplasms
, such as
squamous cell
carcinoma, soft tissue sarcomas have low rates of regional metastases.
Surgery generally has been recommended as the primary method of treatment for achieving local control, except in those high-grade tumours arising in sites
not
amenable to resection.
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[ISSN]
2231-3796
[Journal-full-title]
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
[ISO-abbreviation]
Indian J Otolaryngol Head Neck Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
India
[Other-IDs]
NLM/ PMC3452262
[Keywords]
NOTNLM ; CT Scan / Chemoradiation / Excisional Biopsy / Prognostic factors / Soft tissue sarcoma / Survival rate
67.
Greenberger JS, Epperly MW:
Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization.
In Vivo
; 2007 Mar-Apr;21(2):141-6
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[Title]
Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and
tumor
radiosensitization.
In experiments to determine whether organ-specific radioprotection would also protect orthotopic
tumors
, mice with Lewis lung carcinoma orthotopically placed at the carina or in other experiments with mice with cheek pouch placed SCCVII orthotopic
squamous cell
tumors
demonstrated paradoxical and beneficial
tumor
radiosensitization following intratracheal or intraoral MnSOD-PL, respectively.
The mechanism of MnSOD-PL
tumor
radiosensitization may involve a difference in redox balance between
tumors
and normal tissues.
Differences in handling radiation-induced oxidative stress between
tumors
and normal tissues can provide a fundamental basis to design new cancer therapeutic agents which can exploit differences between normal tissue and
tumor
mechanisms of handling the oxidative stress of ionizing irradiation damage.
[MeSH-major]
Antioxidants / therapeutic use.
Neoplasms
/ radiotherapy. Radiation-Protective Agents / therapeutic use
[MeSH-minor]
Animals. Genetic Therapy / methods. Humans. Lung
Neoplasms
/ radiotherapy. Mice
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(PMID = 17436562.001).
[ISSN]
0258-851X
[Journal-full-title]
In vivo (Athens, Greece)
[ISO-abbreviation]
In Vivo
[Language]
eng
[Grant]
United States / NCI NIH HHS / CA / 1-R01-CA101837-01
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Review
[Publication-country]
Greece
[Chemical-registry-number]
0 / Antioxidants; 0 / Radiation-Protective Agents
[Number-of-references]
73
68.
Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo AA, Ji Y, Leapman RD, Gutkind JS, Rusling JF:
Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice.
Nanomedicine (Lond)
; 2010 Dec;5(10):1535-46
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Efficacy of PEG-SWCNT-cisplatin for
tumor
growth inhibition was studied in mice.
RESULTS & DISCUSSION: PEG-SWCNTs were efficiently dispersed in aqueous media compared with controls, and did
not
induce apoptosis in vitro.
PEG-SWCNT-cisplatin with the attached targeting ligand EGF successfully inhibited growth of head and neck
tumor
xenografts in mice.
CONCLUSIONS: PEG-SWCNTs, as opposed to control SWCNTs, form more highly dispersed delivery vehicles that, when loaded with both cisplatin and EGF, inhibit growth of
squamous cell
tumors
.
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(PMID = 21143032.001).
[ISSN]
1748-6963
[Journal-full-title]
Nanomedicine (London, England)
[ISO-abbreviation]
Nanomedicine (Lond)
[Language]
ENG
[Grant]
United States / NIEHS NIH HHS / ES / R01 ES013557; United States / NIEHS NIH HHS / ES / R01 ES013557-05; United States / NIEHS NIH HHS / ES / ES013557; United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Chemical-registry-number]
0 / Nanotubes, Carbon; 30IQX730WE / Polyethylene Glycols
[Other-IDs]
NLM/ NIHMS323825; NLM/ PMC3175610
69.
Oki-Idouchi CE, Lorenzo PS:
Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin.
Cancer Res
; 2007 Jan 1;67(1):276-80
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[Title]
Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous
tumors
of the skin.
We have recently shown expression of RasGRP1 in the epidermal keratinocytes where it can mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a well-known mouse skin
tumor
promoter.
However, a percentage of the adult transgenic population developed spontaneous skin
tumors
, mainly
squamous cell
papillomas.
The transgene was detected in the
tumors
as well as in primary keratinocytes isolated from transgenic mice.
We noticed a correlation between
tumor
incidence and wounding, which suggests that RasGRP1 overexpression may confer sensitivity to promotional stimuli, like wound repair mechanisms.
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[Cites]
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(PMID = 17210708.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA096841; United States / NCI NIH HHS / CA / 1R01 CA 096841; United States / NCI NIH HHS / CA / R01 CA096841-04
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural
[Publication-country]
United States
[Chemical-registry-number]
0 / Guanine Nucleotide Exchange Factors; 0 / Rasgrp1 protein, mouse
[Other-IDs]
NLM/ NIHMS19989; NLM/ PMC1885541
70.
Créhange G, Bosset M, Lorchel F, Buffet-Miny J, Dumas JL, Mercier M, Puyraveau M, Maingon P, Bosset JF:
Tumor volume as outcome determinant in patients treated with chemoradiation for locally advanced esophageal cancer.
Am J Clin Oncol
; 2006 Dec;29(6):583-7
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[Title]
Tumor
volume as outcome determinant in patients treated with chemoradiation for locally advanced esophageal cancer.
OBJECTIVE: The currently used
tumor
-node metastasis (TNM) staging method is generally
not
applicable to patients with unresectable esophageal carcinomas.
There is a need for both an efficient, easy-to-perform clinical classification and for identification of pretherapeutic prognostic factors that would be useful for oncologists, one of which is
tumor
volume.
Using the computed tomography (CT) scan classification,
tumors
were recorded as follows: 1 T1, 42 T2, 93 T3, 6 T4, 2 Nx, 72 N0, 74 N1.
Tumor
volume from the CT scans was determined as the sum of 2 opposed truncated cones.
Median
tumor
volume was 57.5 cm3 (range, 0.6-288 cm3).
Prognostic factors identified by univariate analysis were: dysphagia grade > or =2, other histology than
squamous cell
,
tumor
location below the carina, age <65 years and
tumor
volume > or =100 cm3.
Prognostic factors identified with multivariate analysis were: dysphagia grade > or =2 (P = 0.013), weight loss > or =10% (P = 0.047),
tumor
location below the carina (P = 0.002), and
tumor
volume > or =100 cm3 (P = 0.041).
CONCLUSIONS: For patients that the TNM staging system is
not
applicable,
tumor
volume is a new powerful determinant of survival.
[MeSH-major]
Esophageal
Neoplasms
/ pathology.
Neoplasm
Staging / methods
Genetic Alliance.
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.
ClinicalTrials.gov.
clinical trials - ClinicalTrials.gov
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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[ErratumIn]
Am J Clin Oncol. 2007 Feb;30(1):7. Fabrice, Lorchel [corrected to Lorchel, Fabrice]
(PMID = 17148995.001).
[ISSN]
1537-453X
[Journal-full-title]
American journal of clinical oncology
[ISO-abbreviation]
Am. J. Clin. Oncol.
[Language]
eng
[Publication-type]
Evaluation Studies; Journal Article
[Publication-country]
United States
71.
Dessolle L, Dalmon C, Roche B, Menain N, Daraï E:
Placental metastases from a maternal squamous cell tumor of the maxillary.
Eur J Obstet Gynecol Reprod Biol
; 2005 Nov 1;123(1):117-8
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[Title]
Placental metastases from a maternal
squamous cell
tumor
of the maxillary.
[MeSH-major]
Maxillary
Neoplasms
/ pathology.
Neoplasms
,
Squamous Cell
/ pathology. Placenta / pathology
[MeSH-minor]
Adult. Cesarean Section. Female. Humans. Infant, Newborn. Maxillary Sinus
Neoplasms
/ drug therapy. Maxillary Sinus
Neoplasms
/ pathology. Maxillary Sinus
Neoplasms
/ radiotherapy.
Neoplasm
Metastasis. Pregnancy. Pregnancy Complications, Neoplastic / etiology
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(PMID = 16225980.001).
[ISSN]
0301-2115
[Journal-full-title]
European journal of obstetrics, gynecology, and reproductive biology
[ISO-abbreviation]
Eur. J. Obstet. Gynecol. Reprod. Biol.
[Language]
eng
[Publication-type]
Case Reports; Letter
[Publication-country]
Ireland
72.
Pagaki E, Patsouris E, Gonidi M, Athanassiadou AM, Maurikakis M, Athanassiades P, Chelidonis G, Athanassiadou P:
The value of E-cadherin/beta-catenin expression in imprints of NCSLC: relationship with clinicopathological factors.
Diagn Cytopathol
; 2010 Jun;38(6):419-24
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[Title]
The
value
of E-cadherin/beta-catenin expression in imprints of NCSLC: relationship with clinicopathological factors.
Metastasis is specific for malignant
tumors
and its control is one of the most important problems in the design of therapies for cancer patients.
Loss or reduction of E-cadherin expression and/or beta-catenin expression plays a casual role in
tumor
progression and metastasis and is associated with poor prognosis.
The purpose of the study is to investigate the expression of E-cadherin and beta-catenin and their significance as independent prognostic markers in imprints of resected nonsmall
cell
lung cancer (NSCLC).
Histologically 47 (67.1%) of the
tumors
were
squamous cell
carcinomas and 23 (32.9%) were adenocarcinomas.
Tumors
stage was I in 29 (41.4%), II in 13 (18.6%), III in 24 (34.3%) and IV in 4 (5.7%).
Positive expression of E-cadherin and beta-catenin was observed in moderate and well differentiated
tumors
(P < 0.0001 for both respectively).
There was no statistically significant association between histological type,
tumor
stage, pleural invasion,
tumor
size (P > 0.05 for all) and E-cadherin/beta-catenin expression.Reduced E-cadherin or beta-catenin negative expression relates to dedifferentiation and progression of NSCLC.
[MeSH-major]
Cadherins / biosynthesis. Carcinoma, Non-Small-
Cell
Lung / metabolism. Carcinoma, Non-Small-
Cell
Lung / pathology. Lung
Neoplasms
/ metabolism. Lung
Neoplasms
/ pathology. beta Catenin / biosynthesis
[MeSH-minor]
Aged. Biomarkers,
Tumor
/ analysis. Humans. Immunohistochemistry. Middle Aged.
Neoplasm
Staging. Prognosis
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[Copyright]
(c) 2010 Wiley-Liss, Inc.
(PMID = 20474081.001).
[ISSN]
1097-0339
[Journal-full-title]
Diagnostic cytopathology
[ISO-abbreviation]
Diagn. Cytopathol.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Biomarkers, Tumor; 0 / Cadherins; 0 / beta Catenin
73.
El Khatib K, Danino A, Trost O, Jidal B, Malka G:
[Use of nasolabial flap for mouth floor reconstruction].
Ann Chir Plast Esthet
; 2005 Jun;50(3):216-20
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SUBJECT: Oral cavity cancers represent 30% of the cephalic extremity
tumors
.
The patients benefited from a surgical resection of the
tumor
by respecting the safety margins, with an immediate reconstruction allowing the restoring of the oral functions.
The majority of
tumors
were
squamous cell
carcinomas (50 cases).
As complications, we noted one complete necrosis and two partial necrosis of the flap, two postoperative wound complications with dehiscence as well as a massive local recurrence of initial
tumor
in one patient.
[MeSH-major]
Mouth
Neoplasms
/ surgery.
Neoplasm
Recurrence, Local. Postoperative Complications. Reconstructive Surgical Procedures / methods. Surgical Flaps
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.
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.
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.
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(PMID = 15896896.001).
[ISSN]
0294-1260
[Journal-full-title]
Annales de chirurgie plastique et esthétique
[ISO-abbreviation]
Ann Chir Plast Esthet
[Language]
fre
[Publication-type]
English Abstract; Journal Article
[Publication-country]
France
74.
Castillo A, Aguayo F, Koriyama C, Shuyama K, Akiba S, Herrera-Goepfert R, Carrascal E, Klinge G, Sánchez J, Eizuru Y:
Human papillomavirus in lung carcinomas among three Latin American countries.
Oncol Rep
; 2006 Apr;15(4):883-8
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We examined HPV genome in 36 lung carcinomas, consisting of 14
squamous cell
carcinomas, 13 adenocarcinomas, and 9 small
cell
carcinomas, collected from Colombia, Mexico and Peru.
This percentage is similar to the
value
of 22% reported by Syrjänen, who conducted a meta-analysis of nearly 2500 lung carcinomas examined to date.
HPV-16 was more frequently found among female than male cases (P=0.008) but was
not
detected in any adenocarcinoma cases.
The presence of HPV tended to be more frequent in well-differentiated
tumors
when
squamous cell
carcinomas and adenocarcinomas were combined.
However, it was
not
statistically significant (P=0.093).
[MeSH-major]
Lung
Neoplasms
/ virology. Papillomaviridae / genetics. Papillomavirus Infections / virology
[MeSH-minor]
Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Adenocarcinoma / virology. Aged. Blotting, Southern. Carcinoma, Small
Cell
/ metabolism. Carcinoma, Small
Cell
/ pathology. Carcinoma, Small
Cell
/ virology. Carcinoma,
Squamous Cell
/ metabolism. Carcinoma,
Squamous Cell
/ pathology. Carcinoma,
Squamous Cell
/ virology. Colombia. Cyclin-Dependent Kinase Inhibitor p16 / analysis. DNA, Viral / chemistry. DNA, Viral / genetics. DNA, Viral / isolation & purification. Female. Genome, Viral. Genotype. Human papillomavirus 16 / genetics. Human papillomavirus 18 / genetics. Humans. Immunohistochemistry. Male. Mexico. Middle Aged. Peru. Sequence Analysis, DNA. Sex Factors.
Tumor
Suppressor Protein p53 / analysis
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(PMID = 16525675.001).
[ISSN]
1021-335X
[Journal-full-title]
Oncology reports
[ISO-abbreviation]
Oncol. Rep.
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Greece
[Chemical-registry-number]
0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
75.
Doi AM, Hailey JR, Hejtmancik M, Toft JD 2nd, Vallant M, Chhabra RS:
Topical application of representative multifunctional acrylates produced proliferative and inflammatory lesions in F344/N rats and B6C3F1 mice, and squamous cell neoplasms in Tg.AC mice.
Toxicol Pathol
; 2005;33(6):631-40
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[Title]
Topical application of representative multifunctional acrylates produced proliferative and inflammatory lesions in F344/N rats and B6C3F1 mice, and
squamous cell neoplasms
in Tg.AC mice.
Topical application of TMPTA and PETA to Tg.AC mice showed dose-dependent increases in
squamous cell
papillomas at the site of application, with decreases in the latency of their appearance in mice receiving 3 mg/kg or greater.
Papillomas, the reporter phenotype in Tg.AC mice, were accompanied by a few
squamous cell
carcinomas, along with hyperplastic and inflammatory lesions.
[MeSH-major]
Acrylates / toxicity. Papilloma / chemically induced. Precancerous Conditions / chemically induced. Propylene Glycols / toxicity. Skin
Neoplasms
/ chemically induced. Stomach
Neoplasms
/ chemically induced
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(PMID = 16176922.001).
[ISSN]
0192-6233
[Journal-full-title]
Toxicologic pathology
[ISO-abbreviation]
Toxicol Pathol
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
[Chemical-registry-number]
0 / Acrylates; 0 / Propylene Glycols; 4B67KGL96S / trimethylolpropane triacrylate; PJJ1161ULF / pentaerythrityl triacrylate
76.
Gevaert O, Daemen A, De Moor B, Libbrecht L:
A taxonomy of epithelial human cancer and their metastases.
BMC Med Genomics
; 2009;2:69
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Additionally, it has
not
yet been extensively investigated whether metastases resemble their tissue of origin or tissue of destination.
Chromophobe renal
cell
carcinoma clustered together with follicular differentiated thyroid carcinoma, which supports recent morphological descriptions of thyroid follicular carcinoma-like
tumors
in the kidney and suggests that they represent a subtype of chromophobe carcinoma.
We also found an expression signature identifying primary
tumors
of
squamous cell
histology in multiple tissues.
Next, a subset of ovarian
tumors
enriched with endometrioid histology clustered together with endometrium
tumors
, confirming that they share their etiopathogenesis, which strongly differs from serous ovarian
tumors
.
In addition, the clustering of colon and breast
tumors
correlated with clinico-pathological characteristics.
Moreover, a signature was developed based on our unsupervised clustering of breast
tumors
and this was predictive for
disease
-specific survival in three independent studies.
A significant part clusters with tissue of origin while the remaining
tumors
cluster with the tissue of destination.
[MeSH-major]
Neoplasm
Metastasis.
Neoplasms
, Glandular and Epithelial / classification.
Neoplasms
, Glandular and Epithelial / pathology. Systems Biology
[MeSH-minor]
Cluster Analysis. Gene Expression Profiling. Genomics. Humans. Internationality.
Neoplasms
, Unknown Primary / therapy. Oligonucleotide Array Sequence Analysis
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[ISSN]
1755-8794
[Journal-full-title]
BMC medical genomics
[ISO-abbreviation]
BMC Med Genomics
[Language]
eng
[Publication-type]
Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
England
[Other-IDs]
NLM/ PMC2806369
77.
Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C:
Activator protein-1 activity regulates epithelial tumor cell identity.
Cancer Res
; 2006 Aug 1;66(15):7578-88
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[Title]
Activator protein-1 activity regulates epithelial
tumor
cell
identity.
When A-FOS was expressed during chemical-induced skin carcinogenesis, mice do
not
develop characteristic benign and malignant
squamous
lesions but instead develop benign sebaceous adenomas containing a signature mutation in the H-ras proto-oncogene.
Inhibiting AP-1 activity after
tumor
formation caused
squamous
tumors
to transdifferentiate into sebaceous
tumors
.
Furthermore, reactivating AP-1 in sebaceous
tumors
results in a reciprocal transdifferentiation into
squamous
tumors
.
In both cases of transdifferentiation, individual cells express molecular markers for both
cell
types, indicating individual
tumor
cells have the capacity to express multiple lineages.
Molecular characterization of cultured keratinocytes and
tumor
material indicates that AP-1 regulates the balance between the wnt/beta-catenin and hedgehog signaling pathways that determine
squamous
and sebaceous lineages, respectively.
Thus, AP-1 activity regulates
tumor
cell
lineage and is essential to maintain the
squamous
tumor
cell
identity.
[MeSH-major]
Adenocarcinoma, Sebaceous / metabolism. Carcinoma,
Squamous Cell
/ metabolism. Skin
Neoplasms
/ metabolism. Transcription Factor AP-1 / metabolism
[MeSH-minor]
Animals. DNA,
Neoplasm
/ metabolism. Hyperplasia. Keratinocytes / metabolism. Mice. Mice, Transgenic. Precancerous Conditions / genetics. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Promoter Regions, Genetic. Protein Binding. Proto-Oncogene Proteins c-fos / biosynthesis. Proto-Oncogene Proteins c-fos / genetics. Proto-Oncogene Proteins c-jun / metabolism. Sebaceous Glands / pathology. Transcriptional Activation. Wnt Proteins / genetics
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(PMID = 16885357.001).
[ISSN]
0008-5472
[Journal-full-title]
Cancer research
[ISO-abbreviation]
Cancer Res.
[Language]
eng
[Grant]
United States / Intramural NIH HHS / /
[Publication-type]
Journal Article; Research Support, N.I.H., Intramural
[Publication-country]
United States
[Chemical-registry-number]
0 / DNA, Neoplasm; 0 / Proto-Oncogene Proteins c-fos; 0 / Proto-Oncogene Proteins c-jun; 0 / Transcription Factor AP-1; 0 / Wnt Proteins
78.
Paruchuri V, Prasad A, McHugh K, Bhat HK, Polyak K, Ganju RK:
S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation.
PLoS One
; 2008 Mar 05;3(3):e1741
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S100A7 is a small calcium binding protein, which has been shown to be differentially expressed in psoriatic skin lesions, as well as in
squamous cell
tumors
of the skin, lung and breast.
Although its expression has been correlated to HER+ high-grade
tumors
and to a high risk of progression, the molecular mechanisms of these S100A7-mediated tumorigenic effects are
not
well known.
Here, we showed for the first time that epidermal growth factor (EGF) induces S100A7 expression in both MCF-7 and MDA-MB-468
cell
lines.
We also observed a decrease in EGF-directed migration in shRNA-downregulated MDA-MB-468
cell
lines.
Furthermore, our signaling studies revealed that EGF induced simultaneous EGF receptor phosphorylation at Tyr1173 and HER2 phosphorylation at Tyr1248 in S100A7-downregulated
cell
lines as compared to the vector-transfected controls.
In addition, reduced phosphorylation of Src at tyrosine 416 and p-SHP2 at tyrosine 542 was observed in these downregulated
cell
lines.
Our results also showed decreased
tumor
-induced osteoclastic resorption in an intra-tibial bone injection model involving SCID mice.
S100A7-downregulated cells had decreased osteoclast number and size as compared to the vector controls, and this decrease was associated with variations in IL-8 expression in in vitro
cell
cultures.
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]
[Cites]
Cancer Res. 1999 Nov 15;59(22):5849-55
[
10582709.001
]
(PMID = 18320059.001).
[ISSN]
1932-6203
[Journal-full-title]
PloS one
[ISO-abbreviation]
PLoS ONE
[Language]
ENG
[Grant]
United States / NCI NIH HHS / CA / R01 CA109527; United States / NCI NIH HHS / CA / CA109527
[Publication-type]
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
[Publication-country]
United States
[Chemical-registry-number]
0 / Calcium-Binding Proteins; 0 / Drug Combinations; 0 / Interleukin-8; 0 / Laminin; 0 / Proteoglycans; 0 / S100 Proteins; 0 / S100A7 protein, human; 0 / S100A7 protein, mouse; 119978-18-6 / matrigel; 42HK56048U / Tyrosine; 62229-50-9 / Epidermal Growth Factor; 9007-34-5 / Collagen; EC 2.7.10.1 / Erbb2 protein, mouse; EC 2.7.10.1 / Receptor, Epidermal Growth Factor; EC 2.7.10.1 / Receptor, ErbB-2
[Other-IDs]
NLM/ PMC2254193
79.
Subhashraj K, Orafi M, Nair KV, El-Gehani R, Elarbi M:
Primary malignant tumors of orofacial region at Benghazi, Libya: a 17 years review.
Cancer Epidemiol
; 2009 Nov;33(5):332-6
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[Title]
Primary malignant
tumors
of orofacial region at Benghazi, Libya: a 17 years review.
The aim of this study was to systematically analyze the clinical presentations of orofacial malignant
tumors
in a Libyan population over a period of 17 years and compare the results with the reports from other countries.
During the study period,
tumors
of epithelial origin were found in 160 patients (82%), followed by
tumors
of immune system, 22 (11%) and
tumors
of mesenchymal origin, 14 (7%).
Of the total malignant
tumors
, 115 were men and 81 were women and the male to female ratio was 1.41:1.
Malignant non-odontogenic
tumors
were seen in 194 patients (99%) and malignant odontogenic
tumors
were seen in 2 patients (1%).
Among the epithelial
tumors
,
squamous cell
carcinoma (50.6%) was the most common
neoplasm
, followed by mucoepidermoid carcinoma (15%) and adenoid cystic carcinoma (8.7%).
[MeSH-major]
Facial
Neoplasms
/ epidemiology. Facial
Neoplasms
/ pathology. Mouth
Neoplasms
/ epidemiology. Mouth
Neoplasms
/ pathology
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(PMID = 19932650.001).
[ISSN]
1877-783X
[Journal-full-title]
Cancer epidemiology
[ISO-abbreviation]
Cancer Epidemiol
[Language]
eng
[Publication-type]
Journal Article; Review
[Publication-country]
Netherlands
[Number-of-references]
35
80.
Domínguez-Cherit J, Chanussot-Deprez C, Maria-Sarti H, Fonte-Avalos V, Vega-Memije E, Luis-Montoya P:
Nail unit tumors: a study of 234 patients in the dermatology department of the "Dr Manuel Gea González" General Hospital in Mexico City.
Dermatol Surg
; 2008 Oct;34(10):1363-71
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[Title]
Nail unit
tumors
: a study of 234 patients in the dermatology department of the "Dr Manuel Gea González" General Hospital in Mexico City.
BACKGROUND: The frequency of nail unit
tumors
is
not
well known because they are often misdiagnosed, and the clinical appearance of benign and malignant
tumors
is
not
characteristic.
RESULTS: The
tumors
most frequently diagnosed were fibrous
tumors
(29.05%), osteocartilaginous
tumors
(21.79%), and myxoid pseudocysts (11.96%).
Malignant melanoma occupied the fourth place (9.82%), and the second most frequent malignant
tumor
was
squamous cell
carcinoma (SCC; 4.70%).
Among other
tumors
were glomus, neurofibromas, giant
cell
tumors
of tendon sheath, and pyogenic granulomas.
CONCLUSION: This study in a Mexican population sheds light on the frequency and the alterations produced by nail unit
tumors
, which we must keep in mind for a more accurate diagnosis.
[MeSH-major]
Nail Diseases / diagnosis. Skin
Neoplasms
/ diagnosis
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.
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consumer health - Skin Cancer
.
NCI CPTC Antibody Characterization Program.
NCI CPTC Antibody Characterization Program
.
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(PMID = 18616533.001).
[ISSN]
1524-4725
[Journal-full-title]
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
[ISO-abbreviation]
Dermatol Surg
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
86.
Falsarella PM, Alves-Filho G, Mazzali M:
Skin malignancies in renal transplant recipients: a Brazilian center registry.
Transplant Proc
; 2008 Apr;40(3):767-8
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Recipients of pancreas kidney transplants or with suspected but
not
biopsy-proven skin malignancy were excluded from this series.
The most frequent skin cancer was
squamous cell
carcinoma (46.2%), in single or multiple lesions (50% each group).
Basal
cell
carcinoma was diagnosed in seven patients; most presented as a single lesion (71.3%).
Eight patients presented with more than one histologic type of skin cancer; most frequently
squamous
and basal
cell
carcinomas.
Kaposi sarcoma was diagnosed in four patients, one of whom also had a basal
cell
carcinoma.
The most frequent
tumor
was
squamous cell
carcinoma, isolated or in association with basal
cell
carcinoma.
[MeSH-major]
Kidney Transplantation / adverse effects. Postoperative Complications / epidemiology. Skin
Neoplasms
/ epidemiology
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.
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.
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(PMID = 18455011.001).
[ISSN]
0041-1345
[Journal-full-title]
Transplantation proceedings
[ISO-abbreviation]
Transplant. Proc.
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
United States
87.
Song XM, Yuan Y, Tao ZJ, Wu HM, Yuan H, Wu YN:
Application of lateral arm free flap in oral and maxillofacial reconstruction following tumor surgery.
Med Princ Pract
; 2007;16(5):394-8
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[Title]
Application of lateral arm free flap in oral and maxillofacial reconstruction following
tumor
surgery.
Sixteen LAFF were harvested to reconstruct defects caused by the dissection of malignant
tumors
of the oral and maxillofacial regions.
The
tumor
was
squamous cell
carcinoma of the tongue (6 cases), floor of the mouth (4), retromolar area (3), inner cheek (2), and lower gingival (1).
[MeSH-major]
Carcinoma,
Squamous Cell
/ surgery. Mouth
Neoplasms
/ surgery. Reconstructive Surgical Procedures / methods. Surgical Flaps
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.
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.
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[Copyright]
2007 S. Karger AG, Basel
(PMID = 17709930.001).
[ISSN]
1423-0151
[Journal-full-title]
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
[ISO-abbreviation]
Med Princ Pract
[Language]
eng
[Publication-type]
Journal Article
[Publication-country]
Switzerland
88.
Sumino Y, Emoto A, Satoh F, Nakagawa M, Mimata H:
Transitional cell carcinoma of the navicular fossa detected human papillomavirus 16.
Int J Urol
; 2006 May;13(5):645-7
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[Title]
Transitional
cell
carcinoma of the navicular fossa detected human papillomavirus 16.
We present a rare case of transitional
cell
carcinoma of the navicular fossa in an elderly man.
We detected the expression of human papillomavirus type 16 specific DNA sequence in the
tumor
using polymerase chain reaction.
Human papillomavirus dissemination into the urethra by urethral instrumentation might cause urethral
tumors
, such as
squamous cell
carcinoma or condyloma acuminatum, and also transitional
cell
carcinoma as seen in the present case.
[MeSH-major]
Carcinoma, Transitional
Cell
/ complications. Carcinoma, Transitional
Cell
/ virology. Human papillomavirus 16 / physiology. Papillomavirus Infections / complications. Papillomavirus Infections / virology. Urethral
Neoplasms
/ complications. Urethral
Neoplasms
/ virology
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(PMID = 16771747.001).
[ISSN]
0919-8172
[Journal-full-title]
International journal of urology : official journal of the Japanese Urological Association
[ISO-abbreviation]
Int. J. Urol.
[Language]
eng
[Publication-type]
Case Reports; Journal Article
[Publication-country]
Australia
89.
Dietl B, Marienhagen J, Schaefer C, Pohl F, Kölbl O:
[Frequency and distribution pattern of distant metastases in patients with ENT tumors and their consequences for pretherapeutic staging].
Strahlenther Onkol
; 2007 Mar;183(3):138-43
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[Title]
[Frequency and distribution pattern of distant metastases in patients with ENT
tumors
and their consequences for pretherapeutic staging].
[Transliterated title]
Häufigkeit und Topographie von Fernmetastasen bei Patienten mit HNO-
Tumoren
und ihre onsequenzen für das prätherapeutische Staging.
PURPOSE: To address the following questions: which parameters influenced the frequency of distant metastases in patients with locally advanced ear-nose-throat (ENT)
tumors
, which was the distribution pattern of metastases, and what were the diagnostic consequences for pretherapeutic staging?
PATIENTS AND METHODS: 600 patients (526 men, 76 women, median age 56 years) with ENT
tumors
(
squamous cell
carcinoma histology) were studied retrospectively.
The distribution of primary
tumor
site and stage (AJCC) was as follows: oropharynx: n = 161 (26.8%), hypopharynx: n = 187 (31.2%), oral cavity: n = 89 (14.8%), larynx: n = 118 (19.7%), cancer of unknown origin: n = 13 (2.2%), others: n = 32(5.3%), I: n = 24 (4%), II: n = 49 (8.2%), III: n = 89 (14.8%), IV: n = 438 (73%).
The following parameters were analyzed in association with distant metastases:
tumor
localization, T- and N-category, primary treatment, local
tumor
control, and second
neoplasms
.
RESULTS: 114/600 patients (19%) developed distant metastases, 29/600 (4.9%) at presentation, 50% within 9.3 months after diagnosis of the primary
tumor
.
Distant metastases were most frequent in stage IV (24.2%), carcinoma of the hypopharynx (25.7%), local recurrence (24.3%), and second
neoplasm
(31.7%) with the following distribution pattern: pulmonary 61/114 (53.5%), pleural 15/114 (13.1%), osseous 45/114 (39.5%), hepatic 14/114 (12.3%), cerebral 8/114 (7%), cutaneous 14/114 (12.3%).
82/600 (13.6%) patients additionally had second
neoplasms
, 20 corresponding with synchronous or metachronous bronchial
tumors
.
CONCLUSION: With locally advanced ENT
tumor
stage IVa/b, carcinoma of the hypopharynx, local recurrence or second
neoplasms
, at least a pretherapeutic CT of the thorax should be performed because every seventh patient (88/600) developed metastases or second primary
tumors
within the thoracic space during the course of
disease
.
Regarding the side effects and costs of curative therapy, the definition of generally accepted guidelines for the systemic staging of locally advanced ENT
tumors
should be undertaken.
[MeSH-major]
Carcinoma,
Squamous Cell
/ secondary. Otorhinolaryngologic
Neoplasms
/ pathology
[MeSH-minor]
Carcinoma, Bronchogenic / pathology. Carcinoma, Bronchogenic / secondary. Combined Modality Therapy.
Disease
Progression. Female. Humans. Lung
Neoplasms
/ pathology. Lung
Neoplasms
/ secondary. Magnetic Resonance Imaging. Male. Middle Aged.
Neoplasm
Metastasis / pathology.
Neoplasm
Staging.
Neoplasms
, Multiple Primary / drug therapy.
Neoplasms
, Multiple Primary / pathology.
Neoplasms
, Multiple Primary / radiotherapy.
Neoplasms
, Multiple Primary / surgery.
Neoplasms
, Second Primary / pathology. Positron-Emission Tomography. Retrospective Studies. Tomography, X-Ray Computed
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(PMID = 17340072.001).
[ISSN]
0179-7158
[Journal-full-title]
Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
[ISO-abbreviation]
Strahlenther Onkol
[Language]
ger
[Publication-type]
English Abstract; Journal Article
[Publication-country]
Germany
90.
Han TJ, Lee CH, Yoo CW, Shin HJ, Park HJ, Cho KH, Park JY, Choi SW, Kim JY:
Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia.
Radiother Oncol
; 2009 Jul;92(1):138-41
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[Title]
Synchronous multifocal HPV-related
neoplasm
involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia.
We report the case of a 32-year-old woman who presented with multiple
squamous cell neoplasms
synchronously arising in the cervix, vulva, oral cavity and oropharynx.
[MeSH-major]
Carcinoma,
Squamous Cell
/ complications. Fanconi Anemia / complications. Genital
Neoplasms
, Female / complications. Head and Neck
Neoplasms
/ complications. Papillomavirus Infections / complications
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(PMID = 19368986.001).
[ISSN]
1879-0887
[Journal-full-title]
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
[ISO-abbreviation]
Radiother Oncol
[Language]
eng
[Publication-type]
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
[Publication-country]
Ireland
91.
Avilés-Izquierdo JA, Velázquez-Tarjuelo D, Lecona-Echevarría M, Lázaro-Ochaita P:
[Dermoscopic features of eccrine poroma].
Actas Dermosifiliogr
; 2009 Mar;100(2):133-6
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Eccrine poroma is a benign adnexal
neoplasm
that clinically may mimic malignant skin
tumors
such as
squamous cell
carcinoma and amelanotic melanoma.
Dermoscopy can improve the clinical diagnosis of this benign adnexal skin
tumor
.
[MeSH-major]
Acrospiroma / pathology. Dermoscopy. Foot Diseases / pathology. Sweat Gland
Neoplasms
/ pathology
[MeSH-minor]
Aged. Aged, 80 and over. Buttocks. Diagnosis, Differential. Female. Humans. Skin
Neoplasms
/ diagnosis
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(PMID = 19445878.001).
[ISSN]
0001-7310
[Journal-full-title]
Actas dermo-sifiliográficas
[ISO-abbreviation]
Actas Dermosifiliogr
[Language]
spa
[Publication-type]
Case Reports; English Abstract; Journal Article
[Publication-country]
Spain
92.
Ruan BF, Huang XF, Ding H, Xu C, Ge HM, Zhu HL, Tan RX:
Synthesis and cytotoxic evaluation of a series of resveratrol derivatives.
Chem Biodivers
; 2006 Sep;3(9):975-81