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[MeSH-major] Brachytherapy. Carcinoma, Squamous Cell / radiotherapy. Carcinoma, Squamous Cell / secondary. Endosonography. Esophageal Neoplasms / pathology

[MeSH-minor] Aged. Biopsy, Fine-Needle. Female. Humans. Lymph Nodes / pathology. Lymph Nodes / radiation effects. Lymphatic Metastasis. Neoplasm Recurrence, Local

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[CommentIn] Gastrointest Endosc. 2005 Nov;62(5):808-10 [16246707.001]

(PMID = 16246706.001).

[ISSN] 0016-5107

[Journal-full-title] Gastrointestinal endoscopy

[ISO-abbreviation] Gastrointest. Endosc.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

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[Title] Epidermotropic Merkel cell carcinoma: a case series with histopathologic examination.

BACKGROUND: Merkel cell carcinoma (MCC), an aggressive malignancy that has been increasing in incidence, rarely presents with an epidermotropic pattern.

In cases 1, 3, and 6, the perinuclear dot pattern observed with cytokeratin-20 in the epidermotropic MCC cells was less pronounced than the pattern observed in the dermis, and in all 6 of the tumors, the epidermal staining pattern observed with epithelial membrane antigen was not more or less prominent than the staining observed in the dermis.

CONCLUSION: The data presented reinforce the differential diagnosis of tumors with an epidermotropic growth pattern and the importance of immunohistochemical staining in the histologic workup of such tumors: squamous cell carcinoma in situ, melanoma, mycosis fungoides, eccrine porocarcinoma, sebaceous carcinoma of the eyelid, mammary and extramammary Paget disease, MCC, and epidermotropic metastases.

It is notable that 3 of 6 identified tumors were located on the eyelid; further study of epidermotropic MCC may shed more light on this finding, either as an unusual coincidence or a finding with unexplained significance.

[MeSH-major] Carcinoma, Merkel Cell / pathology. Eyelid Neoplasms / pathology

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[Copyright] Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

(PMID = 20159312.001).

[ISSN] 1097-6787

[Journal-full-title] Journal of the American Academy of Dermatology

[ISO-abbreviation] J. Am. Acad. Dermatol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Chromogranin A; 0 / Keratin-20

   

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Most of the head and neck tumors are squamous cell carcinomas (SCCs), which are relatively sensitive to chemotherapeutic agents.

The incident rate of end-stage renal disease is 1.3 times higher in the United States than in Japan.

[MeSH-major] Aging / physiology. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / physiopathology. Creatinine / blood. Head and Neck Neoplasms / physiopathology. Kidney Function Tests

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(PMID = 16612154.001).

[ISSN] 0385-0684

[Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy

[ISO-abbreviation] Gan To Kagaku Ryoho

[Language] jpn

[Publication-type] English Abstract; Journal Article

[Publication-country] Japan

[Chemical-registry-number] AYI8EX34EU / Creatinine; BG3F62OND5 / Carboplatin; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil

   

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The chemopreventive and antitumor properties of perillyl alcohol (POH) that were studied preclinically indicate that topical POH inhibits both UVB-induced murine skin carcinogenesis (squamous cell tumor models) and 7,12-dimethylbenz(a)anthracene-induced murine melanoma (transgenic models involving tyrosinase-driven Ras).

There was a borderline reduction in the histopathologic score of the lower-dose POH group compared with the placebo (P = 0.1), but this was not observed in the high-dose group.

No changes were observed in p53 expression, cellular proliferation (by proliferating cell nuclear antigen expression), or apoptosis in either treatment group compared with the placebo group.

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[Cites] Clin Cancer Res. 2000 Feb;6(2):390-6 [10690515.001]

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[CommentIn] Cancer Prev Res (Phila). 2010 Feb;3(2):132-5 [20103730.001]

(PMID = 20103724.001).

[ISSN] 1940-6215

[Journal-full-title] Cancer prevention research (Philadelphia, Pa.)

[ISO-abbreviation] Cancer Prev Res (Phila)

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / P30 CA023074; United States / NCI NIH HHS / CA / P01 CA027502-25; United States / NCI NIH HHS / CA / CA027502; United States / NCI NIH HHS / CA / P30 CA023074-28; United States / NCI NIH HHS / CA / CA023074; United States / NCI NIH HHS / CA / CA027502-25; United States / NCI NIH HHS / CA / P01 CA027502

[Publication-type] Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Chromatin; 0 / Monoterpenes; 319R5C7293 / perilla alcohol

[Other-IDs] NLM/ NIHMS161246; NLM/ PMC3270887

   

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[Title] Monoclonal antibody Ber-EP4 reliably discriminates between microcystic adnexal carcinoma and basal cell carcinoma.

BACKGROUND: Sclerosing cutaneous neoplasms often represent a diagnostic challenge.

It is diagnostically highly reliable in the differentiation between basal cell carcinoma and cutaneous squamous cell carcinoma.

In this study, we report its application in the differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and basal cell carcinoma.

METHODS: Biopsy samples from 28 sclerosing and infiltrating basal cell carcinomas, 13 microcystic adnexal carcinomas and 16 desmoplastic trichoepitheliomas were examined after immunohistochemical staining with Ber-EP4.

RESULTS: Ber-EP4 did not label any of the microcystic adnexal carcinomas, whereas all 28 basal cell carcinomas were Ber-EP4 positive.

Only one basal cell carcinoma was weakly positive.

Twelve of the 16 desmoplastic trichoepitheliomas were immunoreactive with Ber-EP4 and the staining was more variable than those of basal cell carcinomas.

CONCLUSIONS: Ber-EP4 reliably differentiates microcystic adnexal carcinoma from basal cell carcinoma to the same extent as it distinguishes the latter tumor from squamous cell carcinoma.

While it stains the majority of desmoplastic trichoepitheliomas, these tumors still have to be considered in the differential diagnosis with microcystic adnexal carcinoma, when Ber-EP4 is applied.

[MeSH-major] Biomarkers, Tumor / metabolism. Carcinoma, Basal Cell / diagnosis. Carcinoma, Skin Appendage / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis

[MeSH-minor] Biopsy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / metabolism. Diagnosis, Differential. Fluorescent Antibody Technique, Indirect. Humans. Sclerosis / pathology

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(PMID = 17880584.001).

[ISSN] 0303-6987

[Journal-full-title] Journal of cutaneous pathology

[ISO-abbreviation] J. Cutan. Pathol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Denmark

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / human epithelial antigen-125

   

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[Title] Collision tumour of squamous cell carcinoma and invasive malignant melanoma of scalp - a case report.

[MeSH-major] Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / pathology. Melanoma / pathology. Neoplasms, Multiple Primary / pathology. Scalp. Skin Neoplasms / pathology

[MeSH-minor] Aged, 80 and over. Humans. Male. Neoplasm Invasiveness

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(PMID = 19064339.001).

[ISSN] 1878-0539

[Journal-full-title] Journal of plastic, reconstructive & aesthetic surgery : JPRAS

[ISO-abbreviation] J Plast Reconstr Aesthet Surg

[Language] eng

[Publication-type] Case Reports; Letter

[Publication-country] Netherlands

   

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The genome of epithelial tumors is characterized by numerous chromosomal aberrations, DNA base sequence changes, and epigenetic abnormalities.

In squamous cell carcinomas of the lung, CpG methylation patterns undergo substantial changes relative to normal lung epithelium.

Interestingly, a large fraction (almost 80%) of the tumor-specifically methylated sequences are targets of the Polycomb complex in embryonic stem cells.

Homeobox genes are particularly overrepresented and all four HOX gene loci on chromosomes 2, 7, 12, and 17 are hotspots for tumor-associated methylation because of the presence of multiple methylated CpG islands within these loci.

DNA hypomethylation at CpGs in squamous cell tumors preferentially affects repetitive sequence classes including SINEs, LINEs, subtelomeric repeats, and segmental duplications.

Since these epigenetic changes are found in early stage tumors, their contribution to tumor etiology as well as their potential usefulness as diagnostic or prognostic biomarkers of the disease should be considered.

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(PMID = 19429482.001).

[ISSN] 1096-3650

[Journal-full-title] Seminars in cancer biology

[ISO-abbreviation] Semin. Cancer Biol.

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / R01 CA084469; None / None / / R21 CA128495-02; United States / NCI NIH HHS / CA / CA084469; United States / NCI NIH HHS / CA / R01 CA084469-09; United States / NCI NIH HHS / CA / CA128495; None / None / / R01 CA084469-09; United States / NCI NIH HHS / CA / R21 CA128495-02; United States / NCI NIH HHS / CA / R21 CA128495

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Polycomb-Group Proteins; 0 / Repressor Proteins

[Number-of-references] 85

[Other-IDs] NLM/ NIHMS96703; NLM/ PMC2680753

   

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[Title] Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer.

METHODS: Between July 2001 and April 2004, the Eastern Cooperative Oncology Group (ECOG) conducted a randomized study in which 878 patients with recurrent or advanced non-small-cell lung cancer (stage IIIB or IV) were assigned to chemotherapy with paclitaxel and carboplatin alone (444) or paclitaxel and carboplatin plus bevacizumab (434).

Chemotherapy was administered every 3 weeks for six cycles, and bevacizumab was administered every 3 weeks until disease progression was evident or toxic effects were intolerable.

Patients with squamous-cell tumors, brain metastases, clinically significant hemoptysis, or inadequate organ function or performance status (ECOG performance status, >1) were excluded.

The median progression-free survival in the two groups was 6.2 and 4.5 months, respectively (hazard ratio for disease progression, 0.66; P<0.001), with corresponding response rates of 35% and 15% (P<0.001).

CONCLUSIONS: The addition of bevacizumab to paclitaxel plus carboplatin in the treatment of selected patients with non-small-cell lung cancer has a significant survival benefit with the risk of increased treatment-related deaths. (ClinicalTrials.gov number, NCT00021060. )

[MeSH-major] Angiogenesis Inhibitors / administration & dosage. Antibodies, Monoclonal / administration & dosage. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy

[MeSH-minor] Aged. Antibodies, Monoclonal, Humanized. Bevacizumab. Carboplatin / administration & dosage. Carboplatin / adverse effects. Disease-Free Survival. Female. Humans. Kaplan-Meier Estimate. Male. Middle Aged. Paclitaxel / administration & dosage. Paclitaxel / adverse effects. Vascular Endothelial Growth Factor A / blood

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[Copyright] 2006 Massachusetts Medical Society

[CommentIn] N Engl J Med. 2007 Mar 29;356(13):1373; author reply 1374-5 [17396305.001]

[CommentIn] N Engl J Med. 2007 Mar 29;356(13):1373; author reply 1374-5 [17392310.001]

[CommentIn] N Engl J Med. 2007 Mar 29;356(13):1374; author reply 1374-5 [17396304.001]

[CommentIn] N Engl J Med. 2007 Mar 29;356(13):1373-4; author reply 1374-5 [17396306.001]

[ErratumIn] N Engl J Med. 2007 Jan 18;356(3):318

(PMID = 17167137.001).

[ISSN] 1533-4406

[Journal-full-title] The New England journal of medicine

[ISO-abbreviation] N. Engl. J. Med.

[Language] eng

[Databank-accession-numbers] ClinicalTrials.gov/ NCT00021060

[Grant] United States / NCI NIH HHS / CA / CA12046; United States / NCI NIH HHS / CA / CA14548; United States / NCI NIH HHS / CA / CA16116; United States / NCI NIH HHS / CA / CA21076; United States / NCI NIH HHS / CA / CA21115; United States / NCI NIH HHS / CA / CA23318; United States / NCI NIH HHS / CA / CA31946; United States / NCI NIH HHS / CA / CA49957; United States / NCI NIH HHS / CA / CA66636

[Publication-type] Clinical Trial, Phase III; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

[Publication-country] United States

[Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V / Bevacizumab; BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel

   

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[Title] HPV+ cervical carcinomas and cell lines display altered expression of caspases.

OBJECTIVE: Loss of expression of apoptotic regulatory proteins in many neoplasias might result in defective or delayed apoptosis, thus facilitating tumor growth or survival.

We analyzed here, the basal expression of precursors of apoptotic Caspases in normal cervical epithelium, HPV+ cervical tumor samples and HPV+ tumor-derived cell lines.

METHODS: Expression of initiator and effector Caspases was analyzed by immunochemistry in normal cervical epithelium and three types of cervical tumors (squamous cell carcinoma, adenocarcinoma and adenosquamous cell carcinoma) whereas expression of Caspases in HeLa, SiHa and CaSki cells was by immunofluorescence, Western blot and RT-PCR.

RESULTS: Expression of Caspases 3 and 9 was undetectable in adenocarcinoma and adenosquamous cell carcinoma, respectively.

Whereas in squamous cell carcinoma, the expression of Caspases was similar those observed in normal samples.

Expression of Caspases 3 and 6 was low in HeLa and CaSki cells, while Caspase 8 was low in SiHa and it was not detected in C33-A cells.

We did not observe an effect of the E6/E7 oncogenes on the expression of Caspases in C33-A cell.

CONCLUSION: Our results showed a differential expression of several Caspases in carcinoma samples and cell lines, suggesting multiple alterations of the Caspase pathways in cervical cancer.

[MeSH-major] Caspases / biosynthesis. Papillomavirus Infections / enzymology. Uterine Cervical Neoplasms / enzymology. Uterine Cervical Neoplasms / virology

[MeSH-minor] Adenocarcinoma / enzymology. Adenocarcinoma / pathology. Adenocarcinoma / virology. Blotting, Western. Carcinoma, Adenosquamous / enzymology. Carcinoma, Adenosquamous / pathology. Carcinoma, Adenosquamous / virology. Carcinoma, Squamous Cell / enzymology. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / virology. Cell Line, Tumor. Female. Fluorescent Antibody Technique. HeLa Cells. Human papillomavirus 16. Human papillomavirus 18. Humans. Immunohistochemistry. Isoenzymes / biosynthesis. Paraffin Embedding. Reverse Transcriptase Polymerase Chain Reaction

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(PMID = 17936882.001).

[ISSN] 1095-6859

[Journal-full-title] Gynecologic oncology

[ISO-abbreviation] Gynecol. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Isoenzymes; EC 3.4.22.- / Caspases

   

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[Title] Oxford experience with neoadjuvant chemotherapy and surgical resection for esophageal adenocarcinomas and squamous cell tumors.

Since February 2000 it has been our practice to offer this chemotherapy regime to patients with T2 and T3 or T1N1 tumors.

Six patients (5.7%) had progressive disease and were inoperable (discovered in four at surgery).

A total of 182 patients with a median age of 63 (range 30-80), 41 squamous and 141 adenocarcinomas underwent surgery.

A radical surgical approach to the primary tumor in combination with OEO2 neoadjuvant chemotherapy has led to a high R0 resection rate and good survival with acceptable morbidity and mortality.

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(PMID = 18430099.001).

[ISSN] 1442-2050

[Journal-full-title] Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

[ISO-abbreviation] Dis. Esophagus

[Language] ENG

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Cytokine concentrations in basal cell carcinomas of different histological types and localization.

BACKGROUND: Basal cell carcinoma (BCC) is the most common malignant skin tumor.

Cytokines as major mediators of the immune system have been shown to play an important role in biology of the neoplasm with the general predomination of Th2 cytokines, whereas IFN-?

and other Th1 cytokines are prevalent in spontaneously regressing tumors.

OBJECTIVE: We were interested in comparing cytokine levels in BCC and cutaneous squamous cell tumors with BCC of different localization and histological subtypes.

MATERIAL AND METHODS: Explants from freshly excised BCC from 18 patients, and cutaneous squamous cell tumors (solar keratoses and Bowen's disease) from 9 patients were cultivated for 24 h.

RESULTS: Tissue explants of BCC contained significantly higher concentrations of IL-1beta, IL-4, IL-5, and IL-6 compared to those of squamous cell tumors.

Higher levels of TNF-alpha (p = 0.042), IL-4 (p = 0.028), and IL-5 (p = 0.012) were found in tumors localized to the head and neck compared to those on the trunk or extremities.

Interleukin-6 concentrations were higher in aggressive BCC variants (infiltrative and micronodular), but the difference was not statistically significant (p = 0.068).

CONCLUSIONS: Confirming the earlier findings that BCC is a tumor with a Th2 cytokine microenvironment, this study further shows that BCC situated on the head and neck produce even more of certain Th2 cytokines (IL-4 and IL-5) and TNF-alpha, a crucial immunosuppressive cytokine released upon UVB irradiation.

[MeSH-major] Carcinoma, Basal Cell / chemistry. Cytokines / analysis. Skin Neoplasms / chemistry

[MeSH-minor] Aged. Carcinoma, Squamous Cell / chemistry. Female. Humans. Interleukin-4 / analysis. Interleukin-5 / analysis. Male. Tumor Necrosis Factor-alpha / analysis

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(PMID = 18709290.001).

[ISSN] 1318-4458

[Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica

[ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat

[Language] eng

[Publication-type] Journal Article

[Publication-country] Slovenia

[Chemical-registry-number] 0 / Cytokines; 0 / Interleukin-5; 0 / Tumor Necrosis Factor-alpha; 207137-56-2 / Interleukin-4

   

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[Title] Placental site nodule: a tumor-like trophoblastic lesion.

This entity may have bizarre histologic findings and should be distinguished from other aggressive lesions like placental site trophoblastic tumor, epithelioid trophoblastic tumor and squamous cell carcinoma.

[MeSH-major] Gestational Trophoblastic Disease / diagnosis. Placenta Diseases / pathology. Trophoblasts / pathology

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(PMID = 19332926.001).

[ISSN] 0974-5130

[Journal-full-title] Indian journal of pathology & microbiology

[ISO-abbreviation] Indian J Pathol Microbiol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

   

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[Transliterated title] Fibroxantoma atípico. Estudio clinicopatológico de 10 casos.

INTRODUCTION: Atypical fibroxanthoma (AFX) is a rare tumor of unknown histogenesis, considered by most authorities as a superficial form of malignant fibrous histiocytoma (MFH).

Clinical (age, onset-diagnosis time, location, accompanying pathology, outcome), histological (architectural pattern, cell type, ulceration, vascular or perineural invasion, subcutis involvement, pleomorphism, mitosis, inflammatory infiltrate) and immunohistochemical variable were analyzed.

Pathologically all the cases showed a spindle-cell prevalence arranged in a vaguely storiform pattern, along with both, multinucleated and eosinophilic cells.

Other spindle-cell tumors such as squamous cell carcinoma, malignant melanoma, leyomiosarcoma or dermatofibrosarcoma protuberans must be ruled out by immunohistochemical techniques.

[MeSH-major] Histiocytoma, Benign Fibrous / pathology. Skin Neoplasms / pathology

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(PMID = 16476356.001).

[ISSN] 0001-7310

[Journal-full-title] Actas dermo-sifiliográficas

[ISO-abbreviation] Actas Dermosifiliogr

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

   

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Blacks were more likely to be diagnosed at a more advanced stage and to have squamous cell tumors, but were less likely to undergo surgery.

In multivariate regression controlling for age, sex, marital status, histology, and tumor location, black race was associated with worse survival.

When tumor status, surgery, and radiotherapy were added to the model, race was no longer significantly associated with survival.

While the disparity is due in part to differences in tumor histology, diagnosis at an earlier stage and higher rates of surgery among blacks could reduce this survival disparity.

[MeSH-major] Adenocarcinoma / ethnology. Carcinoma, Squamous Cell / ethnology. Esophageal Neoplasms / ethnology. Esophageal Neoplasms / therapy. Healthcare Disparities

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[CommentIn] Ann Surg Oncol. 2008 Mar;15(3):674-6 [18095032.001]

(PMID = 17987341.001).

[ISSN] 1534-4681

[Journal-full-title] Annals of surgical oncology

[ISO-abbreviation] Ann. Surg. Oncol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Oral malignancies following HSCT: graft versus host disease and other risk factors.

Allogenic hematopoietic stem cell transplantation (HSCT), a procedure that is widely used in the treatment of a large number of malignant and non-malignant hematological diseases, is still associated with a wide range of complications, one of the most important of which is graft versus host disease (GVHD).

The patients undergoing allogenic HSCT are also at high risk of developing secondary neoplasms, particularly leukemias and lymphomas.

Solid tumors are less frequent, and the incidence appears to increase over time; the most frequent solid tumors are squamous cell carcinomas.

They include graft versus host disease (GVHD), preoperative regimens, with either radio-chemotherapy or chemotherapy alone, conditioning regimes, immunosuppressive GVHD prophylaxis, viral infection and chronic stimulation as a result of viral antigens, antigenic stimulation from histocompatibility differences between recipient and donor, primary diagnosis, interaction of any of these factors with genetic predisposition, and other factors such as sex and age.

All patients treated with HSCT should therefore be closely followed over the long term with the aim of identifying the onset of secondary tumors as early as possible.

[MeSH-major] Carcinoma, Squamous Cell / etiology. Graft vs Host Disease / etiology. Hematopoietic Stem Cell Transplantation / adverse effects. Mouth Neoplasms / etiology. Neoplasms, Second Primary / etiology

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(PMID = 16084755.001).

[ISSN] 1368-8375

[Journal-full-title] Oral oncology

[ISO-abbreviation] Oral Oncol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Number-of-references] 39

   

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[Title] High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents.

The levels of 3CP were examined by EPRI and MRI for differences in reduction between muscle and tumor (squamous cell carcinoma) implanted in the hind leg of C3H mice simultaneously.

The tumor regions exhibited a faster decay rate of the nitroxide compared to muscle (0.097 min(-1) versus 0.067 min(-1), respectively).

[MeSH-major] Magnetic Resonance Imaging / methods. Neoplasms, Experimental / pathology. Nitrogen Oxides / chemistry

[MeSH-minor] Animals. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Cyclic N-Oxides / chemistry. Cyclic N-Oxides / metabolism. Electron Spin Resonance Spectroscopy / methods. Female. Mice. Mice, Inbred C3H. Models, Chemical. Muscles / metabolism. Oxidation-Reduction. Pyrrolidines / chemistry. Pyrrolidines / metabolism

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(PMID = 16638852.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] eng

[Grant] United States / Intramural NIH HHS / / Z01 NS003047-01

[Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Intramural

[Publication-country] United States

[Chemical-registry-number] 0 / Cyclic N-Oxides; 0 / Nitrogen Oxides; 0 / Pyrrolidines; 14332-28-6 / nitroxyl; 4399-80-8 / 3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-N-oxyl

   

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[Title] Pulmonary hypertension due to isolated metastatic squamous cell carcinoma thromboemboli.

The differential diagnosis of pulmonary hypertension due to arterial tumour embolism is often overlooked and deserves contemplation.

This resulted in the surprising definitive diagnosis of thromboembolic pulmonary hypertension secondary to laminated thrombi of metastatic squamous cell tumour emboli.

The site of tumour origin was however not histologically apparent and was unable to be elucidated on extensive further investigation.

[MeSH-major] Arterial Occlusive Diseases / diagnosis. Hypertension, Pulmonary / diagnosis. Neoplasms, Squamous Cell / diagnosis. Pulmonary Embolism / diagnosis. Thromboembolism / diagnosis

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(PMID = 16412689.001).

[ISSN] 1443-9506

[Journal-full-title] Heart, lung & circulation

[ISO-abbreviation] Heart Lung Circ

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Australia

   

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[Title] Pemetrexed in advanced non-small-cell lung cancer.

IMPORTANCE OF THE FIELD: Current therapeutic options for advanced non-small-cell lung cancer (NSCLC) yield relatively modest improvements in survival leading to an ongoing search for new active treatment agents.

The efficacy of pemetrexed seems to vary between squamous and nonsquamous histologies.

There is growing evidence that, in patients treated with pemetrexed, nonsquamous tumors have improved outcomes compared to squamous cell tumors.

[MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Glutamates / therapeutic use. Guanine / analogs & derivatives. Lung Neoplasms / drug therapy

[MeSH-minor] Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / pathology. Clinical Trials, Phase II as Topic. Clinical Trials, Phase III as Topic. Humans. Pemetrexed. Survival Rate. Treatment Outcome

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(PMID = 20446853.001).

[ISSN] 1744-7666

[Journal-full-title] Expert opinion on pharmacotherapy

[ISO-abbreviation] Expert Opin Pharmacother

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine

[Number-of-references] 92

   

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[Title] Distribution of Bcl-2 gene expression and its prognostic value in non-small cell lung cancer.

The aim of this study was to determine the expression of Bcl-2 gene and prognostic importance of Bcl-2 expression in paraffin embedded blocks of patients diagnosed with non-small cell lung cancer (NSCLC).

These sections are transferred on to slides covered with poly-L-lysine, then de-paraffinization was made.

Positive staining was observed in 9 (19.6%) patients, but not in 37 (80.4%) patients.

Out of 32 cases with squamous cell tumor, 8 (25%) were observed to have positive staining in their sections, but 24 (75%) were not so.

No staining was observed in 11 cases whose cell type was adenoma and two cases whose cell type was adenosquamos (100%).

Staining was present in the section of one case with large cell (100%).

Median survival time was 36.6 months in cases in which staining was observed and 6.10 months in cases in which staining was not observed, with a significant difference (p< 0.05).

[MeSH-major] Carcinoma, Non-Small-Cell Lung / genetics. Gene Expression Regulation, Neoplastic. Genes, bcl-2. Lung Neoplasms / genetics. Proto-Oncogene Proteins c-bcl-2 / biosynthesis

[MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / mortality. Adenocarcinoma / pathology. Adult. Aged. Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate

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(PMID = 16456730.001).

[ISSN] 0494-1373

[Journal-full-title] Tüberküloz ve toraks

[ISO-abbreviation] Tuberk Toraks

[Language] eng

[Publication-type] Journal Article

[Publication-country] Turkey

[Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2

   

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[Title] [Malignant neoplasms of external and middle ear].

[Transliterated title] Nowotwory złośliwe ucha zewnetrznego i środkowego.

INTRODUCTION: Neoplasms of external and middle ear are rare, which cause several problems in diagnosis and therapy.

The purpose of the study was to analyze retrospectively patients with malignant neoplasms of the ear.

METHODOLOGY: The study was carried out on 53 patients treated for malignant ear neoplasms in single institution during 25 years (1978-2002).

RESULTS: The most frequent neoplasm was squamous cell carcinoma--36 cases (67.9%), then basal cell carcinoma--9 cases (16.9%).

Neoplasm primarily involved auricle in 26 patients (49.1%), external auditory canal in 15 patients (28.3%) and middle ear in 12 patients (22.6%).

The characteristics of neoplasms related to the site of location were described.

The difficulties in precise histopathologic diagnosis and extent of disease were pointed out.

RESULTS: Neoplasms of external and middle ear constitute a group of various histopathological and clinical tumours, which differ in diagnostic difficulties, treatment and prognosis.

A diagnosis was often made in advanced stages of neoplasms, especially for middle ear tumours, that diminished a possibility of effective treatment.

[MeSH-major] Ear Neoplasms / pathology. Ear, External. Ear, Middle

[MeSH-minor] Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / pathology. Carcinoma, Basal Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Neoplasm Staging. Ossicular Prosthesis. Retrospective Studies

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(PMID = 16095097.001).

[ISSN] 0030-6657

[Journal-full-title] Otolaryngologia polska = The Polish otolaryngology

[ISO-abbreviation] Otolaryngol Pol

[Language] pol

[Publication-type] English Abstract; Journal Article

[Publication-country] Poland

   

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The cytotoxic activities of these compounds were evaluated against human chronic myeloid leukemia cells (K562) and a human nasopharyngeal epidermoid tumor cell line (KB).

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(PMID = 17311236.001).

[ISSN] 1612-1880

[Journal-full-title] Chemistry & biodiversity

[ISO-abbreviation] Chem. Biodivers.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Switzerland

[Chemical-registry-number] 0 / Antineoplastic Agents; DH2M523P0H / Genistein

   

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RESULTS: Ten tumors were squamous cell carcinoma and one tumor was chondrosarcoma occurring within the radiation field of previous treatment for NPC.

Six tumors were located in the external auditory canal, two in the middle ear cavity, two in the periauricular region and one in the mastoid cavity.

The 3-year disease-free and overall survival rates were 30.3% and 20%, respectively.

[MeSH-major] Carcinoma, Squamous Cell / etiology. Chondrosarcoma / etiology. Ear Neoplasms / etiology. Nasopharyngeal Neoplasms / radiotherapy. Neoplasms, Radiation-Induced / etiology. Neoplasms, Second Primary / etiology

[MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Disease-Free Survival. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Radiotherapy Dosage. Radiotherapy, Adjuvant. Retrospective Studies

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(PMID = 18948828.001).

[ISSN] 1531-4995

[Journal-full-title] The Laryngoscope

[ISO-abbreviation] Laryngoscope

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

   

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[Title] Exons 19 and 21 of epidermal growth factor receptor are highly conserved in squamous cell cancer of the head and neck.

EGFR inhibitors might be more effective in patients whose tumors harbor specific EGFR mutations.

The presence of specific EFGR mutations is predictive of over a 75% response rate to TKI therapies as compared to 10% in wild type cases of non-small cell lung cancer.

Design. DNA was extracted from 20 head and neck squamous cell tumors and 4 squamous cell carcinoma cell lines and sequenced the receptor using published primer pairs.

Results. No exon 19 or 21 mutations were found in any of the 20 tumors and 0 of 4 cell lines.

Based on the tumor data we would predict that no greater than 8% of head and neck tumors (CI 97.5%) would be likely to harbor either of these mutations.

Conclusions. Our findings are comparable to results recently published of Korean, Austrian, and Spanish patient populations and we conclude that exon 19 and 21 EGFR mutations are not more common in head and neck cancer than in nonsmall-cell carcinoma.

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(PMID = 20130810.001).

[ISSN] 1687-921X

[Journal-full-title] International journal of otolaryngology

[ISO-abbreviation] Int J Otolaryngol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2814135

   

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[Title] Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status.

Mutations in EGFR (exon 19 and 21) and KRAS (codons 12 and 13) and their impact on response and survival with respect to tumor subtype and smoking status were assessed.

No EGFR effect was recorded for squamous cell tumors.

KRAS mutation in tumors did not result in a poorer prognosis in the subtype-selected groups, nor did it present as a negative factor in smokers.

KRAS does not seem an "a priori" negative factor for TKI-based treatment of NSCLC.

[MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Genes, ras. Lung Neoplasms / drug therapy. Mutation. Protein Kinase Inhibitors / therapeutic use. Receptor, Epidermal Growth Factor / genetics. Smoking

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(PMID = 19596959.001).

[ISSN] 1791-7530

[Journal-full-title] Anticancer research

[ISO-abbreviation] Anticancer Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Greece

[Chemical-registry-number] 0 / Codon; 0 / DNA Primers; 0 / Protein Kinase Inhibitors; EC 2.7.10.1 / Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor, Epidermal Growth Factor

   

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[Title] Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer.

Results showed that six out 12 ferrets exposed to both NNK injection and cigarette smoke developed grossly identifiable lung tumors whereas none of nine ferrets from the sham treatment group developed any lung lesions.

The histopathological types of these tumors (squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma) in ferret lungs are very similar to those in humans.

In addition, 10 out of 12 ferrets exposed to both NNK and cigarette smoke developed preneoplastic lesions (squamous metaplasia, dysplasia, and atypical adenomatous hyperplasia) with complex growth patterns whereas the sham group did not show any of these lesions.

Furthermore, the expression of proliferating cellular nuclear antigen increased markedly in both gross tumors and preneoplastic lesions in the lungs.

In summary, the development of both preneoplastic lesions and gross lung tumors in ferrets provides an excellent and unique model for studying lung cancer chemoprevention with agents such as carotenoids, and for studying the molecular mechanism of carcinogenesis in the earlier stages of smoke-related lung cancer.

[MeSH-major] Carcinogens / toxicity. Disease Models, Animal. Ferrets. Lung Neoplasms / etiology. Nitrosamines / toxicity. Smoking / adverse effects

[MeSH-minor] Adenocarcinoma / etiology. Adenocarcinoma / pathology. Animals. Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / pathology. Humans. Immunohistochemistry. Male. Precancerous Conditions / etiology. Precancerous Conditions / pathology

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(PMID = 15894421.001).

[ISSN] 0304-3835

[Journal-full-title] Cancer letters

[ISO-abbreviation] Cancer Lett.

[Language] eng

[Grant] United States / NIDDK NIH HHS / DK / T32 DK062032

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

[Publication-country] Ireland

[Chemical-registry-number] 0 / Carcinogens; 0 / Nitrosamines; 64091-91-4 / 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

   

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[Transliterated title] Cuidados vocais: questão de prevenção e saúde.

Considering all the patients attended, only one presented malignant neoplasm (squamous cell carcinoma), confirmed later by biopsy.

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(PMID = 20922288.001).

[ISSN] 1678-4561

[Journal-full-title] Ciência & saúde coletiva

[ISO-abbreviation] Cien Saude Colet

[Language] por

[Publication-type] English Abstract; Journal Article

[Publication-country] Brazil

   

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A mass was endoscopically detected in his right posterior oropharyngeal wall, and biopsy revealed a neoplasm consisting of a uniform population of plasma cells.

Computed tomography (CT) showed a broad-based papillary soft tissue density mass projecting into the oropharynx from the right posterior wall of the pharynx, and post-contrast CT showed marked enhancement of the tumor.

The tumor showed slightly higher signal intensity compared with surrounding muscle on MR Tl-weighted images (T1WI) and high signal intensity on MR T2-weighted images (T2WI).

Following radiation therapy, a reduction in tumor size was observed.

Although SEP is a rare tumor, it should be included in the differential diagnosis of tumors of the oropharynx because of its imaging similarities to other, more common malignant tumors, such as squamous cell carcinoma and lymphoma.

[MeSH-major] Oropharyngeal Neoplasms / diagnosis. Plasmacytoma / diagnosis

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(PMID = 16555568.001).

[ISSN] 0288-2043

[Journal-full-title] Radiation medicine

[ISO-abbreviation] Radiat Med

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

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[Title] Subglottic tracheal stenosis as primary manifestation of a marginal zone B-cell lymphoma of the larynx.

BACKGROUND: More than 90% of laryngeal tumors are squamous cell carcinomas.

Primary hematopoetic neoplasms of the larynx are rare, being mainly extramedullary plasmocytoma and non-Hodgkin's lymphoma (NHL).

The biopsy revealed the diagnosis of a MALT-type lymphoma (marginal zone B-cell lymphoma).

[MeSH-major] Laryngeal Neoplasms / diagnosis. Lymphoma, B-Cell, Marginal Zone / diagnosis. Tracheal Stenosis / etiology

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(PMID = 15875774.001).

[ISSN] 0258-851X

[Journal-full-title] In vivo (Athens, Greece)

[ISO-abbreviation] In Vivo

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Greece

   

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[Title] Metastatic tumor of squamous cell carcinoma from uterine cervix to heart: ante-mortem diagnosis.

The pathological examination revealed metastasis of squamous cells with well-differentiated infiltrative areas.

Four months later, however, she was readmitted to hospital in terminal stage, confirming the guarded prognosis of the disease at this stage.

[MeSH-major] Carcinoma, Squamous Cell / secondary. Heart Neoplasms / secondary. Uterine Cervical Neoplasms / pathology

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(PMID = 17128293.001).

[ISSN] 1678-4170

[Journal-full-title] Arquivos brasileiros de cardiologia

[ISO-abbreviation] Arq. Bras. Cardiol.

[Language] eng; por

[Publication-type] Case Reports; Journal Article

[Publication-country] Brazil

   

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The histopathological types of cervical tumors were: squamous cell carcinoma 80%, adenosquamous carcinoma 15% and adenocarcinoma 5%.

[MeSH-major] Hysterectomy. Uterine Cervical Neoplasms / pathology

[MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Magnetic Resonance Imaging. Middle Aged. Neoplasm Staging

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(PMID = 18404786.001).

[ISSN] 1107-0625

[Journal-full-title] Journal of B.U.ON. : official journal of the Balkan Union of Oncology

[ISO-abbreviation] J BUON

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

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The aim of this study was to assess the usefulness of fine needle aspiration cytology (FNAC) as a diagnostic method in lung tumour as well as to determine the incidence of lung cancer in various age and sex group and in relation with smoking.

The most common tumour was squamous cell carcinoma (45%) followed by adenocarcinoma (22%), small cell carcinoma (16%) and large cell carcinoma (8%).

[MeSH-major] Biopsy, Fine-Needle. Lung Neoplasms / diagnosis

[MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / epidemiology. Adult. Age Factors. Aged. Aged, 80 and over. Carcinoma, Large Cell / diagnosis. Carcinoma, Large Cell / epidemiology. Carcinoma, Small Cell / diagnosis. Carcinoma, Small Cell / epidemiology. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Cytodiagnosis. Female. Histocytochemistry. Humans. Male. Middle Aged. Predictive Value of Tests. Risk Factors. Smoking

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(PMID = 17474260.001).

[ISSN] 0377-4929

[Journal-full-title] Indian journal of pathology & microbiology

[ISO-abbreviation] Indian J Pathol Microbiol

[Language] eng

[Publication-type] Journal Article

[Publication-country] India

   

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[Title] Tumor cavitation during therapy with antiangiogenesis agents in patients with lung cancer.

Tumor cavitation is frequently noted in these patients, but the clinical significance of this finding has not been fully determined.

Our purposes were to evaluate the frequency, imaging characteristics, and clinical outcome of patients receiving antiangiogenesis agents who develop tumor cavitation, and correlate these findings with therapy related adverse events, especially hemoptysis.

Seventeen patients developed tumor cavitation during the trial (14%; median time to event, 1.8 months; range, 0.7-6.2 months), 16 patients (13%) had preexisting cavitary tumors, and 91 (73%) did not develop cavitation.

Cavity formation was more common with squamous cell histology (p = 0.04) but was not associated with hemoptysis (p = 0.12), tumor location (central versus peripheral), imaging characteristics, progression-free survival (p = 0.56), or overall survival (p = 0.33).

One of five patients with hemoptysis was fatal in a cavitary squamous cell tumor.

CONCLUSION: Development of tumor cavitation is not rare in lung cancer patients treated with antiangiogenesis agents, but the clinical implications are minimal in most cases.

[MeSH-major] Angiogenesis Inhibitors / therapeutic use. Carcinoma, Non-Small-Cell Lung / drug therapy. Lung Neoplasms / drug therapy

[MeSH-minor] Adenocarcinoma, Bronchiolo-Alveolar / blood supply. Adenocarcinoma, Bronchiolo-Alveolar / drug therapy. Adenocarcinoma, Bronchiolo-Alveolar / secondary. Adult. Aged. Aged, 80 and over. Carcinoma, Large Cell / blood supply. Carcinoma, Large Cell / drug therapy. Carcinoma, Large Cell / secondary. Carcinoma, Squamous Cell / blood supply. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / secondary. Female. Follow-Up Studies. Humans. Male. Middle Aged. Retrospective Studies. Survival Rate

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(PMID = 18379352.001).

[ISSN] 1556-1380

[Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

[ISO-abbreviation] J Thorac Oncol

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Angiogenesis Inhibitors

   

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[Title] Squamous cell carcinoma of the lip after allogeneic hemopoietic stem cell transplantation.

Allogeneic hemopoietic stem cell transplantation (HSCT) has been considered a curative treatment option for many hematological and non-hematological disorders.

Despite the use of advanced methods of tissue typing and new therapies, graft versus host disease (GVHD) remains a major obstacle.

Secondary malignancies are also among the most serious long-term complications after HSCT including leukemia, lymphomas, and to a lesser extent, solid tumors.

The most commonly observed solid tumor is squamous cell carcinoma (SCC).

[MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Hematopoietic Stem Cell Transplantation. Lip Neoplasms / pathology. Lip Neoplasms / surgery. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery

[MeSH-minor] Adult. Graft vs Host Disease / pathology. Graft vs Host Disease / surgery. Humans. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology. Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy. Male. Multiple Myeloma / pathology. Multiple Myeloma / therapy. Transplantation, Homologous

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(PMID = 20543542.001).

[ISSN] 1658-3876

[Journal-full-title] Hematology/oncology and stem cell therapy

[ISO-abbreviation] Hematol Oncol Stem Cell Ther

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Saudi Arabia

   

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BACKGROUND & OBJECTIVE: EMS1 (chromosome eleven, band q13, mammary tumor and squamous cell carcinoma-associated gene 1) is correlated to the genesis, progression, invasion and metastasis of some malignancies.

METHODS: The expression of EMS1 protein in 20 specimens of normal gastric mucosa, 38 specimens of intraepithelial neoplasia, and 146 specimens of gastric carcinoma was detected by immunohistochemistry.

The positive rate of EMS1 protein was significantly higher in gastric carcinoma than in intraepithelial neoplasia and normal gastric mucosa (89.7% vs. 68.4% and 20.0%, P<0.001), and significantly higher in intraepithelial neoplasia than in normal gastric mucosa (P<0.001).

EMS1 protein expression had no correlations to sex, age, tumor differentiation and diameter.

[MeSH-major] Cortactin / genetics. Stomach Neoplasms / genetics

[MeSH-minor] Adult. Aged. Female. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging

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(PMID = 18334127.001).

[Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer

[ISO-abbreviation] Ai Zheng

[Language] chi

[Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China

[Chemical-registry-number] 0 / CTTN protein, human; 0 / Cortactin

   

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In addition, many salivary gland tumors and squamous cell carcinomas had strong D2-40 expression, sometimes making distinction of lymphatics versus tumor edge staining difficult.

D2-40 is excellent for assessing lymphatic invasion in breast, prostate, and cervix as long as the pathologist is aware of the expression in myoepithelial cells/basal cells to avoid misinterpretation of ductal carcinoma in situ or normal prostate glands or tumor stroma retraction as tumor lymphatic invasion.

Given the patchy positivity in basal cells of skin and mucosa and the reactivity in squamous cell carcinoma, D2-40 was not helpful in assessing for microinvasion of squamous cell carcinoma.

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(PMID = 20042851.001).

[ISSN] 1533-4058

[Journal-full-title] Applied immunohistochemistry & molecular morphology : AIMM

[ISO-abbreviation] Appl. Immunohistochem. Mol. Morphol.

[Language] ENG

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Membrane Glycoproteins; 0 / PDPN protein, human

   

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[Title] Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.

Mutations in both p53 and BRCA2 are commonly seen together in human tumors suggesting that the loss of both genes enhances tumor development.

We found decreased survival and timing of tumor onsets, and significantly higher overall tumor incidences and prevalence of particular tumors, including stomach tumors and squamous cell carcinomas, associated with the homozygous loss of Brca2, independent of p53 status.

The addition of a p53 mutation had a further impact on overall survival, incidence of osteosarcomas and stomach tumors, and tumor latency.

The spectrum of tumors observed for this Brca2 germline mouse model suggest that it faithfully recapitulates some human disease phenotypes associated with BRCA2 loss.

In addition, these findings include extensive in vivo data demonstrating that germline Brca2 and p53 mutations cooperatively affect animal survivals, tumor susceptibilities, and tumor onsets.

[MeSH-major] BRCA2 Protein / genetics. Genes, p53. Germ-Line Mutation. Neoplasms / genetics. Neoplasms, Radiation-Induced / genetics. Radiation, Ionizing

[MeSH-minor] Animals. Bone Neoplasms / genetics. Bone Neoplasms / physiopathology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / physiopathology. Female. Gene Expression Regulation, Neoplastic. Genetic Predisposition to Disease. Genotype. Mice. Mice, Inbred C57BL. Mice, Mutant Strains. Osteosarcoma / genetics. Osteosarcoma / physiopathology. Phenotype. Stomach Neoplasms / genetics. Stomach Neoplasms / physiopathology. Survival Rate. Time Factors

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(PMID = 16546942.001).

[ISSN] 0192-6233

[Journal-full-title] Toxicologic pathology

[ISO-abbreviation] Toxicol Pathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / BRCA2 Protein; 0 / BRCA2 protein, mouse

   

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Survivin overexpression has been reported in relation to tumor malignancy, suggesting that it is an unfavorable prognostic marker, and antibody responses to this protein have been confirmed in human cancer patients.

The cut-off value for positivity in the anti-survivin ELISA was 0.35, as determined using the mean absorbance +2 S.D. of samples from healthy dogs.

Sera from 16 of 59 (27.1%) cancer and 3 of 25 (12%) non-cancer disease dogs were positive on ELISA.

The highest positivity rates (>50%) among the cancer cases were seen in dogs with mammary tumor, squamous cell carcinoma and melanoma.

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(PMID = 20179386.001).

[ISSN] 0916-7250

[Journal-full-title] The Journal of veterinary medical science

[ISO-abbreviation] J. Vet. Med. Sci.

[Language] ENG

[Publication-type] Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Autoantibodies; 0 / DNA Primers; 0 / Microtubule-Associated Proteins

   

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[Title] Premalignant neoplasms and squamous cell carcinoma of the anal margin.

Understanding anal anatomy and performing a biopsy of any suspicious lesions are essential in avoiding a delay in diagnosis and appropriately treating these tumors.

Combined multimodality treatment has come to play an important role in managing patient with more advanced or metastatic disease.

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(PMID = 20011315.001).

[ISSN] 1530-9681

[Journal-full-title] Clinics in colon and rectal surgery

[ISO-abbreviation] Clin Colon Rectal Surg

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Other-IDs] NLM/ PMC2780101

[Keywords] NOTNLM ; Anus neoplasms / Bowen's disease / Paget's disease / squamous cell cancer

   

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[Title] Immunolabeling pattern of podoplanin (d2-40) may distinguish basal cell carcinomas from trichoepitheliomas: a clinicopathologic and immunohistochemical study of 49 cases.

When the morphologic distinction between basal cell carcinomas (BCCs) and tichoepitheliomas is unclear, it poses a rare diagnostic challenge as the commonly defined histologic criterion is insufficient for differentiating these two neoplasms from each other.

Their distinction is clinically important because the risk of progressive disease in BCC can be problematic, and trichoepitheliomas misinterpreted as BCC burdens the patient with an inaccurate diagnosis and consequential inappropriate surgery.

Podoplanin (D2-40) is a well-known lymphatic endothelial surface marker that has been postulated to be upregulated in the outer root sheath of hair follicles and cutaneous neoplasms, such as adnexal tumors, squamous cell carcinomas, etc.

We studied the expression of D2-40 by immunohistochemistry to determine if this marker could reliably differentiate these neoplasms from each other.

A total of 49 cutaneous tumors, including 22 cases of trichoepitheliomas and 27 cases of BCC were examined.

This data suggests that D2-40 expression could be a useful potential marker to distinguish BCCs from trichoepitheliomas, especially when there is a high index of histologic suspicion for either of these two tumors.

[MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Basal Cell / diagnosis. Membrane Glycoproteins / biosynthesis. Neoplasms, Basal Cell / diagnosis. Skin Neoplasms / diagnosis

[MeSH-minor] Antibodies, Monoclonal. Antibodies, Monoclonal, Murine-Derived. Diagnosis, Differential. Humans. Immunohistochemistry. Predictive Value of Tests

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(PMID = 20559122.001).

[ISSN] 1533-0311

[Journal-full-title] The American Journal of dermatopathology

[ISO-abbreviation] Am J Dermatopathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / Membrane Glycoproteins; 0 / PDPN protein, human; 0 / monoclonal antibody D2-40

   

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[Title] Endoscopic submucosal dissection of esophageal squamous cell neoplasms.

BACKGROUND & AIMS: Endoscopic submucosal dissection (ESD) has recently been developed for en bloc resection of stomach neoplasms, which results in high tumor eradication rates as well as a modality for the precise histologic assessment of the entire lesion.

Application of the technique is desirable for esophageal squamous cell neoplasms (SCNs), but there have been no reports on the use of this procedure in the esophagus.

METHODS: An ESD with methods similar to those used for resections of early gastric cancer was performed on 58 consecutive esophageal SCNs with preoperative diagnoses of intraepithelial neoplasm or intramucosal invasive carcinoma occurring in 43 enrolled patients.

RESULTS: The rate of en bloc resection was 100% (58/58), and en bloc resection with tumor-free lateral/basal margins (R0 resection) was 78% (45/58).

Of 40 lesions occurring in 31 patients fulfilling the criteria of node-negative tumors (mean follow-up, 17 months), 1 lesion resected by en bloc resection with nonevaluable tumor-free lateral margins (Rx [lateral] resection) recurred locally 6 months after ESD, which was treated successfully by a second ESD procedure.

[MeSH-major] Esophageal Neoplasms / surgery. Esophagoscopy. Neoplasms, Squamous Cell / surgery

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(PMID = 16713746.001).

[ISSN] 1542-3565

[Journal-full-title] Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

[ISO-abbreviation] Clin. Gastroenterol. Hepatol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Coloring Agents; 9679TC07X4 / Iodine

   

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AIMS AND BACKGROUND: To compare conventional fractionation (CF) radiation therapy (RT), arm A, versus a split-course accelerated hyperfractionated schedule (S-AHF), arm B, versus CFRT plus concomitant chemotherapy (CT), arm C, in terms of five-year survival and toxicity for squamous cell tumors of the oropharynx.

Five-year second-tumor-free survival was 85%.

The 13 second tumors were equally distributed and were mainly correlated with tobacco and alcohol consumption (five lung, two esophagus, two oral cavity, one larynx, one pancreas, one hepatocarcinoma, one myeloma).

CONCLUSIONS: The results obtained with the combination of CT and RT compared with RT alone did not reach statistical significance, but combined treatment almost doubled the five-year overall survival, relapse-free survival and locoregional control rate.

Patients with advanced squamous cell carcinomas of the oropharynx who are medically suitable for the combined approach should be treated with a combination of radiotherapy and chemotherapy.

The occurrence of second tumors is relatively common in these patients and may contribute substantially to the causes of death.

[MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / radiotherapy. Oropharyngeal Neoplasms / drug therapy. Oropharyngeal Neoplasms / radiotherapy

[MeSH-minor] Aged. Biomarkers, Tumor / analysis. Carboplatin / administration & dosage. Chemotherapy, Adjuvant / adverse effects. Dose Fractionation. Female. Fluorouracil / administration & dosage. Humans. Male. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / drug therapy. Neoplasms, Second Primary / radiotherapy. Radiotherapy, Adjuvant / adverse effects. Radiotherapy, Adjuvant / methods. Risk Factors. Salvage Therapy. Survival Analysis. Time Factors. Treatment Failure. Treatment Outcome

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(PMID = 16683383.001).

[ISSN] 0300-8916

[Journal-full-title] Tumori

[ISO-abbreviation] Tumori

[Language] eng

[Publication-type] Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor; BG3F62OND5 / Carboplatin; U3P01618RT / Fluorouracil

   

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Keratoacanthoma (KA) is a common keratinizing squamous cell neoplasm of unknown origin characterized by rapid growth and spontaneous involution.

Lack of papillomatosis and viral inclusions ruled out the diagnosis of viral wart, absence of granulomatous reaction ruled out deep fungal or mycobacterial infection and lack of cytological atypia and frank architectural abnormalities did not favour a squamous cell carcinoma.

Diagnosis can be challenging as differential diagnoses include pseudoepitheliomatous hyperplasia and squamous cell carcinoma.

[MeSH-minor] Adult. Carcinoma, Squamous Cell / diagnosis. Diagnosis, Differential. Female. Histiocytes / pathology. Humans. Keratinocytes / pathology. Keratins / analysis. Lymphocytes / pathology. Skin Neoplasms / diagnosis

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(PMID = 17976209.001).

[ISSN] 1600-0560

[Journal-full-title] Journal of cutaneous pathology

[ISO-abbreviation] J. Cutan. Pathol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Denmark

[Chemical-registry-number] 0 / Coloring Agents; 68238-35-7 / Keratins

   

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[Title] Expression of human beta-defensins-1, 2 and 4 mRNA in human lung tumor tissue: a pilot study.

AIM: To analyze the patterns of human beta-defensin-1, 2, 4 (hBDs) expression in human lung tumors.

MATERIALS AND METHODS: Tissue samples of surgically resected human lung tumors (squamous cell carcinoma (SCC), n=10; adenocarcinoma (AC), n=10) paired with conditionally normal tissue samples were analyzed for expression of hBD-1, 2, 4 mRNA by semiquantitative RT-PCR.

No correlation was detected between the levels of hBD-1, hBD-2 and hBD-4 mRNA and histological type, differentiation grade of the tumor, and the stage of the disease, as well as the content of hBD-2 peptide in blood serum of lung cancer patients.

CONCLUSION: Human beta-defensins-1 and -2 are often up-regulated in human lung tumors.

[MeSH-major] Gene Expression Regulation, Neoplastic. Lung Neoplasms / metabolism. Up-Regulation. beta-Defensins / biosynthesis

[MeSH-minor] Cell Line, Tumor. Cohort Studies. Humans. Pilot Projects. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Tissue Distribution

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(PMID = 18566581.001).

[ISSN] 1812-9269

[Journal-full-title] Experimental oncology

[ISO-abbreviation] Exp. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Ukraine

[Chemical-registry-number] 0 / DEFB1 protein, human; 0 / DEFB4A protein, human; 0 / RNA, Messenger; 0 / beta-Defensins

   

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[Title] [Expression pattern of MAL in normal epithelial cells, benign tumor, and squamous cell carcinoma of larynx].

METHOD: Use the immunohistochemical technique to analyze the distribution of MAL in normal laryngeal epithelial cells, polyp of vocal cords, laryngeal atypical hyperplasia and laryngeal squamous cell carcinoma.

Comparatively, MAL expression is significantly down regulated in laryngeal atypical hyperplasia and laryngeal squamous cell carcinomas (P < 0.05).

MAL, therefore, is a potential marker for early diagnosis of laryngeal squamous cell carcinoma.

[MeSH-major] Carcinoma, Squamous Cell / metabolism. Laryngeal Mucosa / metabolism. Laryngeal Neoplasms / metabolism. Membrane Transport Proteins / metabolism. Myelin Proteins / metabolism. Proteolipids / metabolism

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(PMID = 19670627.001).

[ISSN] 1001-1781

[Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

[ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi

[Language] chi

[Publication-type] English Abstract; Journal Article

[Publication-country] China

[Chemical-registry-number] 0 / MAL protein, human; 0 / Membrane Transport Proteins; 0 / Myelin Proteins; 0 / Myelin and Lymphocyte-Associated Proteolipid Proteins; 0 / Proteolipids

   

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[Title] Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition.

PURPOSE: This study aimed to identify molecular determinants of sensitivity of non-small cell lung cancer (NSCLC) to anti-insulin-like growth factor receptor (IGF-IR) therapy.

EXPERIMENTAL DESIGN: A total of 216 tumor samples were investigated, of which 165 consisted of retrospective analyses of banked tissue and an additional 51 were from patients enrolled in a phase II study of figitumumab, a monoclonal antibody against IGF-IR, in stage IIIb/IV NSCLC.

RESULTS: IGF-IR was differentially expressed across histologic subtypes (P = 0.04), with highest levels observed in squamous cell tumors.

Elevated IGF-IR expression was also observed in a small number of squamous cell tumors responding to chemotherapy combined with figitumumab (P = 0.008).

Furthermore, a higher response rate to the combination of chemotherapy and figitumumab was observed in transitional tumors (71%) compared with those in the mesenchymal-like subset (32%; P = 0.03).

Only one epithelial-like tumor was identified in the phase II study, suggesting that advanced NSCLC has undergone significant dedifferentiation at diagnosis.

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[Copyright] ©2010 AACR.

[Cites] Appl Immunohistochem Mol Morphol. 2009 Jul;17(4):329-37 [19318915.001]

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[RetractionIn] Clin Cancer Res. 2014 Jun 15;20(12):3358 [24928947.001]

(PMID = 20670944.001).

[ISSN] 1078-0432

[Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research

[ISO-abbreviation] Clin. Cancer Res.

[Language] ENG

[Grant] United States / NIEHS NIH HHS / ES / R01 ES015704-04; United States / NCI NIH HHS / CA / P50CA58183; United States / NIEHS NIH HHS / ES / R01 ES015704; United States / NIEHS NIH HHS / ES / ES015704; United States / NCI NIH HHS / CA / P50 CA058183; United States / NCI NIH HHS / CA / R01 CA094118

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Retracted Publication; Validation Studies

[Publication-country] United States

[Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antineoplastic Agents; 0 / Hormone Antagonists; 0 / Immunoglobulins, Intravenous; 67763-96-6 / Insulin-Like Growth Factor I; VE267FC2UB / figitumumab

[Other-IDs] NLM/ NIHMS226076; NLM/ PMC2952544

   

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[Title] [Molecular alterations in nodal metastases and its primary tumors in squamous cell carcinomas of the larynx].

[Transliterated title] Alteraciones moleculares en las metástasis ganglionares y sus tumores primarios en los carcinomas epidermoides de laringe.

INTRODUCTION AND OBJECTIVES: The successive acquisition of molecular alterations determines tumour progression.

During this progression, the development of nodal metastases is one of the most important prognostic factors in laryngeal squamous cell carcinomas.

The aim of this study is to analyze if, in these carcinomas, the molecular alterations in the nodal metastases are different from those present in the primary tumour.

MATERIAL AND METHOD: Paired samples of primary tumour and nodal metastases from 51 patients with squamous cell carcinoma of the supraglottic larynx were studied.

RESULTS: A close correlation in the expression of the proteins studied was observed in the nodal metastases and the corresponding primary tumour, with the exception of HIF-1a expression and the degree of vascularization.

CONCLUSIONS: Most of the molecular alterations in the nodal metastases are already present in the primary tumour, suggesting that these alterations are early events in carcinogenesis.

[MeSH-major] Carcinoma, Squamous Cell / secondary. Laryngeal Neoplasms / pathology

[MeSH-minor] Humans. Immunohistochemistry. Lymphatic Metastasis. Neoplasm Proteins / biosynthesis

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(PMID = 18364203.001).

[ISSN] 0001-6519

[Journal-full-title] Acta otorrinolaringológica española

[ISO-abbreviation] Acta Otorrinolaringol Esp

[Language] spa

[Publication-type] English Abstract; Journal Article

[Publication-country] Spain

[Chemical-registry-number] 0 / Neoplasm Proteins

   

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The aim of this study was to determine the number of cases of laryngeal cancer seen at the Korle Bu Teaching Hospital, establish epidemiological parameters of the disease and to outline preventive measures.

METHOD: One hundred and fifteen (115) patients who were managed for laryngeal cancer from 1(st) January 1998 to 31(st) December 2003 were studied retrospectively with respect to age, sex, duration of symptoms at presentation, risk factors, symptoms complex, histopathology, stage of tumor, details of treatment offered and follow up.

A significant proportion of cases (37.3%) presented with locally advanced disease.

The commonest histological type of laryngeal tumour seen was squamous cell carcinoma.

Only 58 (69.9%) patients completed radiotherapy treatment and in all 32 (24.3 %) patients did not report for any treatment.

CONCLUSIONS: We conclude that significant number of patients with laryngeal cancer presented with locally advanced disease and dysphonia was the commonest symptom.

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[Cites] Laryngoscope. 1975 Jul;85(7):1190-6 [1152568.001]

[Cites] Int J Radiat Oncol Biol Phys. 1991 Jan;20(1):21-8 [1993628.001]

[Cites] Am J Surg. 1991 Oct;162(4):337-40 [1951884.001]

(PMID = 17299565.001).

[ISSN] 0016-9560

[Journal-full-title] Ghana medical journal

[ISO-abbreviation] Ghana Med J

[Language] eng

[Publication-type] Journal Article

[Publication-country] Ghana

[Other-IDs] NLM/ PMC1790844

   

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We treated a patient with hypopharyngeal fibromatous polyp and speculated the mechanism of this disease.

The greater part of hypopharyngeal tumors is squamous cell carcinomas, and benign tumors are really uncommon.

Fibromatous polyp is not thought to be a true tumor, but the symptoms are almost the same as tumorous diseases, e.g., discomfort in the throat, swallowing difficulty and respiratory distress.

[MeSH-major] Hypopharyngeal Neoplasms / diagnosis. Polyps / diagnosis

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(PMID = 16504437.001).

[ISSN] 0385-8146

[Journal-full-title] Auris, nasus, larynx

[ISO-abbreviation] Auris Nasus Larynx

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Netherlands

   

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[Title] Prognostic role of the tumor-associated tissue inflammatory reaction in transitional bladder cell carcinoma.

Many authors have indicated that the presence of an inflammatory response within the tumor may predict not only recurrence and progression but also survival in several tumors, including transitional cell carcinoma (TCC) of the urinary bladder.

The aim of the present study was to define the influence of inflammatory cell infiltrate on recurrence, progression and survival in TCC of the bladder over a long follow-up period.

Between January and December 1995, 410 consecutive patients, who had undergone transurethral or open surgery for bladder tumors at the same urologic center, were selected for the study.

All cases were reviewed to assess histotype, stage and grade of the tumor and presence or absence of tumor-associated inflammatory reaction.

Pathologic evaluation showed superficial TCC in 312 patients, while 98 had an invasive bladder tumor.

Three among 410 bladder tumors were squamous cell carcinomas.

Out of 407 TCCs, 119 (29.23%) presented inflammation within the tumor or the lamina propria.

At 10 years follow-up, a statistically significant association was shown between the presence of inflammation within the tumor or lamina propria and the number of recurrences (p<0.0001).

Moreover, the absence of inflammatory infiltrate in the tumor established the relative risk of suffering more than one recurrence at 2.287 (95% CI 1.180-3.346).

The Mann-Whitney test confirmed a statistically significant difference between superficial bladder tumors with inflammation and those without (26.3 vs 11.5 months, p<0.001).

On multivariate analysis, the presence of inflammation within the tumor was found to be an independent predictor of survival in patients with TCC of the bladder (p=0.027).

Survival analysis by means of the Kaplan-Meier curves showed a statistically significant difference between patients with tumor-associated inflammatory reaction and those without (p=0.0098).

These results confirm that the presence of inflammatory reaction has a good prognostic value in transitional bladder cell carcinoma.

However, to better define its prognostic significance, the characterization of inflammatory cells in tumor-associated tissue reaction must be accomplished.

[MeSH-major] Carcinoma, Transitional Cell / mortality. Carcinoma, Transitional Cell / pathology. Urinary Bladder Neoplasms / mortality. Urinary Bladder Neoplasms / pathology

[MeSH-minor] Adult. Aged. Disease Progression. Female. Humans. Inflammation / diagnosis. Inflammation / pathology. Male. Middle Aged. Neoplasm Recurrence, Local / diagnosis. Neoplasm Recurrence, Local / mortality. Neoplasm Recurrence, Local / pathology. Neoplasm Staging. Prognosis

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(PMID = 16820911.001).

[ISSN] 1021-335X

[Journal-full-title] Oncology reports

[ISO-abbreviation] Oncol. Rep.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Greece

   

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[Title] Carcinosarcoma of the oesophagus - a rare mixed type of tumor.

Oesophageal carcinosarcoma is a rare type of oesophageal cancer composed of both squamous cells and sarcomatous cells.

On surgical pathology, it was discovered that the tumor had both squamous cell and sarcomatous cell components, and the final diagnosis was changed to oesophageal carcinosarcoma.

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[Copyright] © JSCR.

(PMID = 24946341.001).

[ISSN] 2042-8812

[Journal-full-title] Journal of surgical case reports

[ISO-abbreviation] J Surg Case Rep

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Other-IDs] NLM/ PMC3649142

   

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[Title] Expression of peptidylarginine deiminase type 4 in ovarian tumors.

The current study focused on the expression of PADI4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on PADI4 expression in SKOV-3 cells that originated from ovary tumors.

We utilized immunohistochemistry, real-time PCR and western blotting to analyze the expression of PADI4 in the tumor tissues and in the cell line that were cultured with estrodial-17β.

PADI4 was detected in serious cystadenocarcinoma (n=39, positivity=100%), clear cell cancer (n=7, positivity= 100%), mucinous cystadenocarcinoma (n=6, positivity=100%), dysgerminoma (n=6, positivity=100%), squamous cell tumor (n=6, positivity=100%), sibnet-ring cell carcinoma (n=6, positivity=100%), endodermal sinus tumor (n=6, positivity=100%), germ cell tumors (n=6, positivity=100%) and immature teratoma (n=6, positivity=100%).

However, PADI4 was either not detected or detected at low levels in granulosa cell tumor (n=6), malignant thecoma (n=6), ovarian cystadenoma (n=5) and normal ovarian tissue (n=11).

PADI4 was evenly distributed in the cytoplasm of tumor cells of serious cystadenocarcinoma that were classified as being grade II and III by histopathological scoring.

However, PADI4 showed granular cellular distribution in the tumor tissues that were isolated from grade I cystadenocarcinoma.

[MeSH-major] Hydrolases / metabolism. Ovarian Neoplasms / enzymology

[MeSH-minor] Blotting, Western. Cell Line, Tumor. Estradiol / pharmacology. Estradiol / physiology. Female. Gene Expression / drug effects. Humans. Immunohistochemistry. Polymerase Chain Reaction. RNA, Messenger / metabolism

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(PMID = 20827398.001).

[ISSN] 1449-2288

[Journal-full-title] International journal of biological sciences

[ISO-abbreviation] Int. J. Biol. Sci.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Australia

[Chemical-registry-number] 0 / RNA, Messenger; 4TI98Z838E / Estradiol; EC 3.- / Hydrolases; EC 3.5.3.15 / peptidylarginine deiminase type IV

[Other-IDs] NLM/ PMC2935668

[Keywords] NOTNLM ; Peptidylarginine deiminase type 4 (PADI4/PAD4) / estrodial-17β. / ovarian cancer (OCa)

   

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Specific subsets include women with peritoneal carcinomatosis, women with isolated axillary lymph node metastases, adenocarcinoma presenting as a single metastatic lesion, young men with features of extragonadal germ cell tumor, squamous carcinoma involving cervical or inguinal lymph nodes, and neuroendocrine carcinoma.

[MeSH-major] Neoplasms, Unknown Primary / therapy

[MeSH-minor] Biomarkers, Tumor / analysis. Humans. Prognosis

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(PMID = 19179187.001).

[ISSN] 0093-7754

[Journal-full-title] Seminars in oncology

[ISO-abbreviation] Semin. Oncol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers, Tumor

[Number-of-references] 58

   

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Tumor-associated trypsin-2 and matrix metalloprotease-9 (MMP-9) are associated with cancer, particularly with invasive squamous cell carcinomas.

We describe here that oral squamous cell carcinomas express all members of this cascade: MMP-9, trypsin-2 and enterokinase.

The expression of enterokinase in a carcinoma cell line not derived from the duodenum was shown here for the first time.

However, although both proteases were present also in various bone tumor tissues, MMP-9 and trypsin-2 never co-localized at the cellular level in these tissues.

This suggests that the intracellular vesicular co-localization, storage and possible activation of these proteases may be a unique feature for aggressive epithelial tumors, such as squamous cell carcinomas, but not for tumors of mesenchymal origin.

[MeSH-major] Carcinoma, Squamous Cell / enzymology. Enteropeptidase / metabolism. Matrix Metalloproteinase 9 / metabolism. Mouth Neoplasms / enzymology. Trypsin / metabolism. Trypsinogen / metabolism

[MeSH-minor] Bone Neoplasms / enzymology. Carcinoma / enzymology. Cell Line, Tumor. Enzyme Precursors / metabolism. Humans

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(PMID = 18062964.001).

[ISSN] 0014-4827

[Journal-full-title] Experimental cell research

[ISO-abbreviation] Exp. Cell Res.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Enzyme Precursors; 103964-84-7 / PRSS2 protein, human; 9002-08-8 / Trypsinogen; EC 3.4.21.4 / Trypsin; EC 3.4.21.9 / Enteropeptidase; EC 3.4.24.- / pro-matrix metalloproteinase 9; EC 3.4.24.35 / Matrix Metalloproteinase 9

   

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The median age was 49.8 years; all but 1 tumor were squamous cell carcinomas.

Ten (83.3%) had pelvic and systemic disease, whereas only 2 had systemic disease alone.

A single patient having metastatic disease in the lung showed stabilization for 6 months to then progressing in bone.

Despite lack of activity of single-agent imatinib, further studies in cervical cancer are deserved to better define the status of imatinib targets in this tumor and to investigate its activity in combination with cytotoxic drugs.

[MeSH-major] Carcinoma, Squamous Cell / drug therapy. Piperazines / therapeutic use. Pyrimidines / therapeutic use. Receptor, Platelet-Derived Growth Factor alpha / metabolism. Uterine Cervical Neoplasms / drug therapy

[MeSH-minor] Adult. Aged. Antineoplastic Agents / adverse effects. Antineoplastic Agents / therapeutic use. Benzamides. Chemotherapy, Adjuvant. Female. Humans. Imatinib Mesylate. Middle Aged. Neoplasm Metastasis. Recurrence. Survival Analysis. Treatment Outcome

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(PMID = 19955950.001).

[ISSN] 1525-1438

[Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

[ISO-abbreviation] Int. J. Gynecol. Cancer

[Language] eng

[Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate; EC 2.7.10.1 / Receptor, Platelet-Derived Growth Factor alpha

   

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The morphological features of epithelioid sarcoma may closely mimic those of epithelial neoplasms, such as squamous cell carcinoma, mesenchymal tumors, such as benign fibrous histiocytoma, and nonneoplastic lesions, such as granuloma annulare.

Recently, loss of expression of INI1, a tumor suppressor gene/protein, and expression of GLUT-1, a glucose transporter protein, have been described in epithelioid sarcoma.

Twenty-four cases of epithelioid sarcoma, 13 cases of granuloma annulare, 10 cases of rheumatoid nodule, 19 cases of cutaneous squamous cell carcinoma, 7 cases of atypical fibroxanthoma, 9 cases of benign fibrous histiocytoma (dermatofibroma), and 3 cases of nodular fasciitis were immunostained for GLUT-1 and INI1 using commercially available antibodies, heat-induced epitope retrieval, and the Dako Envision detection system.

GLUT-1 was positive in 40%-50% of epithelioid sarcomas, all cases of granuloma annulare and rheumatoid nodules, 67% of benign fibrous histiocytomas, and in all squamous cell carcinomas.

In this clinical context, loss of INI1 expression seems to be an entirely specific marker of epithelioid sarcoma and this finding may be of great value in distinguishing CD34-negative epithelioid sarcoma from squamous cell carcinoma and in the distinction of rare cytokeratin-negative epithelioid sarcomas from necrobiotic processes, nodular fasciitis, and benign fibrous histiocytomas.

In contrast, there does not seem to be a role for GLUT-1 immunohistochemistry in this differential diagnosis.

[MeSH-major] Chromosomal Proteins, Non-Histone / metabolism. DNA-Binding Proteins / metabolism. Glucose Transporter Type 1 / metabolism. Granuloma Annulare / metabolism. Sarcoma / metabolism. Skin Diseases / metabolism. Skin Neoplasms / metabolism. Transcription Factors / metabolism

[MeSH-minor] Biomarkers / metabolism. Diagnosis, Differential. Fasciitis / metabolism. Fasciitis / pathology. Histiocytoma, Benign Fibrous / metabolism. Histiocytoma, Benign Fibrous / pathology. Humans. Neoplasms, Squamous Cell / metabolism. Neoplasms, Squamous Cell / pathology. Rheumatoid Nodule / metabolism. Rheumatoid Nodule / pathology. Xanthomatosis / metabolism. Xanthomatosis / pathology

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(PMID = 19318800.001).

[ISSN] 1533-0311

[Journal-full-title] The American Journal of dermatopathology

[ISO-abbreviation] Am J Dermatopathol

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Biomarkers; 0 / Chromosomal Proteins, Non-Histone; 0 / DNA-Binding Proteins; 0 / Glucose Transporter Type 1; 0 / SMARCB1 protein, human; 0 / Transcription Factors

   

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[Title] Radiotherapy treatment delays and their influence on tumour control achieved by various fractionation schedules.

There is often a considerable delay from initial tumour diagnosis to the start of radiotherapy treatment.

This paper extends the calculations of a previous paper on the effects of delays before the initiation of radiotherapy treatment to include results from a variety of practical fractionation regimes for three different types of tumour: squamous cell carcinoma (head and neck), breast and prostate.

The linear quadratic model of radiation effect, logarithmic tumour growth (coupled with delay times where relevant) and the Poisson model for tumour control probability (TCP) are used to calculate the change in TCP for delays between diagnosis and treatment.

The results show that delays in the start of radiotherapy treatment do have an adverse effect on tumour control for fast-growing tumours.

For example, calculations predict a reduction in local tumour control of up to 1.5% per week's delay for head and neck cancers treated following surgery.

In addition, there may be a variety of fractionation regimes that will yield very similar clinical results for each tumour type.

It is shown theoretically that, for the tumour types considered here, it is possible to increase the dose per fraction and decrease the number of fractions while maintaining or increasing TCP relative to standard 2 Gy fractionation regimes, although there may be some advantage to using hyperfractionated regimes for head and neck cancers in order to reduce normal tissue effects.

[MeSH-major] Breast Neoplasms / radiotherapy. Head and Neck Neoplasms / radiotherapy. Prostatic Neoplasms / radiotherapy

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(PMID = 18378526.001).

[ISSN] 1748-880X

[Journal-full-title] The British journal of radiology

[ISO-abbreviation] Br J Radiol

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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[Title] Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes.

A mutation of Atp2a2 gene encoding the sarco/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) causes Darier's disease in human and null mutation in one copy of Atp2a2 leads to a high incidence of squamous cell tumor in a mouse model.

In SERCA2 heterozygote (SERCA2(+/-)) mice keratinocytes, mechanisms involved in partial depletion of SERCA2 gene and its related tumor induction have not been studied.

Using the gene fishing system, we first found in SERCA2(+/-) keratinocytes that gene level of tumor-associated calcium signal transducer 1, crystalline alphaB, procollagen XVIII alpha1, and nuclear factor I-B were increased.

These results suggest that the alterations of Ca(2+) signaling by SERCA2 haploinsufficiency alternate the gene expression of tumor induction and differentiation in keratinocytes.

[MeSH-major] Carcinoma, Squamous Cell / metabolism. Heterozygote. Keratinocytes / metabolism. Sarcoplasmic Reticulum Calcium-Transporting ATPases / genetics. Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism

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[Copyright] Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.

(PMID = 19840814.001).

[ISSN] 1873-1732

[Journal-full-title] Progress in biophysics and molecular biology

[ISO-abbreviation] Prog. Biophys. Mol. Biol.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] England

[Chemical-registry-number] 0 / Biomarkers; EC 3.6.3.8 / Sarcoplasmic Reticulum Calcium-Transporting ATPases

   

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Single topical application of AO (0.15-0.3 ml) or isolated sanguinarine (4.5-18 micromol) followed by twice-weekly application of tetradecanoylphorbolmyristate acetate (TPA) for 25 weeks resulted in formation of tumors.

Histopathologically these tumors were of squamous cell carcinoma type and similar to those found in the positive control group using dimethylbenzanthracene (DMBA)/TPA.

Although the genotoxic lesions may be repaired to some extent on withdrawal of consumption of AO contaminated mustard oil and the residual genotoxic effects caused by AO may not be expressed as signs of carcinogenesis.

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[Copyright] Copyright 2005 Wiley-Liss, Inc

(PMID = 15981203.001).

[ISSN] 0020-7136

[Journal-full-title] International journal of cancer

[ISO-abbreviation] Int. J. Cancer

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] United States

[Chemical-registry-number] 0 / Alkaloids; 0 / Benzophenanthridines; 0 / Carcinogens; 0 / Isoquinolines; 0 / Plant Oils; 0 / argemone oil; AV9VK043SS / sanguinarine

   

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All tumors were squamous cell carcinoma, arising at the glottis in 21 cases and the supraglottis in 12 cases.

Five-year disease-specific survival rates for stage III of glottic cancer, stage IV of glottic cancer, stage III of supraglottic cancer, and stage IV of supraglottic cancer were 100%, 56.3%, 100%, and 28.1%, respectively.

Both of them died of disease despite undergoing chemotherapy.

[MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / therapy

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(PMID = 20879822.001).

[ISSN] 0365-5237

[Journal-full-title] Acta oto-laryngologica. Supplementum

[ISO-abbreviation] Acta Otolaryngol Suppl

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

   

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For more than 60 years, the chemical induction of tumors in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors.

Subsequently, tumor development is elicited by repeated treatment with a tumor-promoting agent.

The initiation protocol can be completed within 1-3 h depending on the number of mice used; whereas the promotion phase requires twice weekly treatments (1-2 h) and once weekly tumor palpation (1-2 h) for the duration of the study.

Using the protocol described here, a highly reproducible papilloma burden is expected within 10-20 weeks with progression of a portion of the tumors to squamous cell carcinomas within 20-50 weeks.

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(PMID = 19713956.001).

[ISSN] 1750-2799

[Journal-full-title] Nature protocols

[ISO-abbreviation] Nat Protoc

[Language] ENG

[Grant] United States / NCI NIH HHS / CA / CA076520; United States / NCI NIH HHS / CA / P30 CA016672; United States / NIEHS NIH HHS / ES / ES007784; United States / NCI NIH HHS / CA / R01 CA037111; United States / NCI NIH HHS / CA / CA016672; United States / NIEHS NIH HHS / ES / R01 ES016623; United States / NIEHS NIH HHS / ES / ES015718; United States / NIEHS NIH HHS / ES / P30 ES007784; United States / NIEHS NIH HHS / ES / R01 ES016623-02; United States / NIEHS NIH HHS / ES / ES016623; United States / NCI NIH HHS / CA / CA37111; United States / NCI NIH HHS / CA / R01 CA076520

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] England

[Chemical-registry-number] 0 / Carcinogens

[Other-IDs] NLM/ NIHMS334643; NLM/ PMC3213400