[X] Close
You are about to erase all the values you have customized, search history, page format, etc.
Click here to RESET all values       Click here to GO BACK without resetting any value
Items 1 to 100 of about 3494
1. Fonseca-Moutinho JA: [Vulvar intraepithelial neoplasia: a current problem]. Rev Bras Ginecol Obstet; 2008 Aug;30(8):420-6
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vulvar intraepithelial neoplasia: a current problem].
  • [Transliterated title] Neoplasia intraepitelial vulvar: um problema atual.
  • Vulvar intraepithelial neoplasia (VIN) is a pathological denomination coined by the International Society for Study of Vulvo-vaginal Diseases (ISSVD) and adopted by the International Society of Gynaecological Pathology (ISGYP) and by the World Health Organization.
  • The high-risk human papillomavirus (HR-HPV) infection, human immunodeficiency virus (HIV) infection, smoking, cervical, vaginal and rectal intraepithelial neoplasia are considered to be high risk factors for development of VIN.
  • [MeSH-major] Carcinoma in Situ. Vulvar Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19142526.001).
  • [ISSN] 1806-9339
  • [Journal-full-title] Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
  • [ISO-abbreviation] Rev Bras Ginecol Obstet
  • [Language] por
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Brazil
  • [Number-of-references] 50
  •  go-up   go-down


2. Membrilla-Fernández E, Parés D, Alameda F, Pascual M, Courtier R, Gil MJ, Vallecillo G, Fusté P, Pera M, Grande L: [Anal intraepithelial neoplasia: application of a diagnostic protocol in risk patients using anal cytology]. Cir Esp; 2009 Jun;85(6):365-70
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia: application of a diagnostic protocol in risk patients using anal cytology].
  • [Transliterated title] Neoplasia intraepitelial anal: resultados de la aplicación de un protocolo diagnóstico en pacientes de riesgo mediante el uso de citología anal.
  • INTRODUCTION: Anal intraepithelial neoplasia is a precursor condition of squamous anal carcinoma.
  • The groups at risk of this lesion are patients with anogenital condylomata, cervical dysplasia, human immunodeficiency virus infection and, in general, patients with HPV infection.
  • The aim of this study was to analyse the results of a diagnostics protocol of Anal Intraepithelial Neoplasia in high risk population using anal cytology.
  • In the overall series, 25 patients have been diagnosed with abnormal anal cytology: 9 atypical squamous cells of undetermined significance (ASCUS), 15 low-grade and 1 high-grade squamous intraepithelial lesions.
  • CONCLUSIONS: Our diagnostic protocol of anal intraepithelial neoplasia revealed 25% of patients with pre-invasive lesions of squamous anal cancer.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19303590.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


3. Preti VB, Hatschbach SB, Linhares JC, Guerreiro JA, Minari CL, Maestri CA, Fonseca FV: [High-grade cervical intraepithelial neoplasia during pregnancy: experience in a service in southern Brazil]. Rev Bras Ginecol Obstet; 2009 Dec;31(12):604-8
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [High-grade cervical intraepithelial neoplasia during pregnancy: experience in a service in southern Brazil].
  • [Transliterated title] Neoplasia intraepitelial cervical de alto grau durante a gestação: experiência de um serviço do Sul do Brasil.
  • PURPOSE: to evaluate the results of treatment to which patients with high grade intraepithelial cervical neoplasia (HSIL) are submitted, as well as their follow-up during pregnancy.
  • METHODS: retrospective study based on the review of the medical report of 30 patients with diagnosis of high-grade squamous intraepithelial lesions (HSIL) during pregnancy and attended to at a tertiary hospital in southern Brazil from 1990 to 2002.
  • RESULTS: from 30 patients, 3 were excluded of the sample because the diagnosis of high-grade squamous intraepithelial lesions (HSIL) was not confirmed by the colposcopy with biopsia.
  • The expectant procedure for intraepithelial lesions is the most widely chosen and safe due to the possibility of regression in the postpartum period.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / diagnosis. Cervical Intraepithelial Neoplasia / therapy. Uterine Cervical Neoplasms / diagnosis. Uterine Cervical Neoplasms / therapy

  • Genetic Alliance. consumer health - Cervical Intraepithelial Neoplasia.
  • Genetic Alliance. consumer health - Pregnancy.
  • MedlinePlus Health Information. consumer health - Cervical Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20101375.001).
  • [ISSN] 1806-9339
  • [Journal-full-title] Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
  • [ISO-abbreviation] Rev Bras Ginecol Obstet
  • [Language] por
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Brazil
  •  go-up   go-down


Advertisement
4. Parés D, Mullerat J, Pera M: [Anal intraepithelial neoplasia]. Med Clin (Barc); 2006 Nov 18;127(19):749-55
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia].
  • [Transliterated title] Neoplasia intraepitelial anal.
  • Human papillomavirus (HPV) is responsible for anal condylomata, anal intraepithelial neoplasia (AIN) and anal squamous cell carcinoma.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17198654.001).
  • [ISSN] 0025-7753
  • [Journal-full-title] Medicina clínica
  • [ISO-abbreviation] Med Clin (Barc)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 58
  •  go-up   go-down


5. Torres-Rendon A, Roy S, Craig GT, Speight PM: Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas. Br J Cancer; 2009 Apr 7;100(7):1128-34
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas.
  • Mcm2 and geminin have been scarcely explored in oral epithelial dysplasia (OED) and oral squamous-cell carcinoma (OSCC).
  • [MeSH-major] Carcinoma, Squamous Cell / chemistry. Cell Cycle Proteins / analysis. Ki-67 Antigen / analysis. Mouth Mucosa / chemistry. Mouth Neoplasms / chemistry. Nuclear Proteins / analysis. Precancerous Conditions / chemistry

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Cell Sci. 2004 Nov 15;117(Pt 24):5875-86 [15522891.001]
  • [Cites] Clin Cancer Res. 1999 Aug;5(8):2121-32 [10473096.001]
  • [Cites] Clin Cancer Res. 2005 Apr 1;11(7):2510-7 [15814627.001]
  • [Cites] Exp Cell Res. 2005 Sep 10;309(1):56-67 [16005865.001]
  • [Cites] Br J Cancer. 2005 Nov 28;93(11):1295-300 [16278669.001]
  • [Cites] Br J Cancer. 2006 Apr 24;94(8):1170-5 [16622441.001]
  • [Cites] Liver Int. 2006 May;26(4):424-32 [16629645.001]
  • [Cites] J Oral Pathol Med. 2006 Jul;35(6):369-75 [16762018.001]
  • [Cites] J Oral Pathol Med. 2008 Jan;37(1):1-10 [18154571.001]
  • [Cites] Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8956-61 [18579778.001]
  • [Cites] Lancet. 1999 Oct 30;354(9189):1524-5 [10551502.001]
  • [Cites] Neuropathol Appl Neurobiol. 2001 Aug;27(4):305-13 [11532161.001]
  • [Cites] Clin Cancer Res. 2001 Sep;7(9):2712-8 [11555583.001]
  • [Cites] Gut. 2002 Mar;50(3):290-1 [11839701.001]
  • [Cites] Gut. 2002 Mar;50(3):373-7 [11839717.001]
  • [Cites] Pathobiology. 2001;69(3):150-8 [11872961.001]
  • [Cites] Am J Pathol. 2002 Jul;161(1):267-73 [12107111.001]
  • [Cites] Mol Cell Biol. 2003 Apr;23(7):2351-61 [12640120.001]
  • [Cites] Head Neck. 2003 Apr;25(4):267-73 [12658730.001]
  • [Cites] J Oral Pathol Med. 2003 Sep;32(8):468-74 [12901728.001]
  • [Cites] Br J Cancer. 2003 Sep 15;89(6):1048-54 [12966424.001]
  • [Cites] Br J Cancer. 2004 Jul 19;91(2):262-9 [15199392.001]
  • [Cites] Eur J Biochem. 2004 Aug;271(16):3368-78 [15291814.001]
  • [Cites] Br J Cancer. 2004 Aug 16;91(4):714-9 [15266314.001]
  • [Cites] J Pathol. 2004 Oct;204(2):121-30 [15376260.001]
  • [Cites] J Immunol. 1984 Oct;133(4):1710-5 [6206131.001]
  • [Cites] J Cell Sci. 1994 Jan;107 ( Pt 1):253-65 [8175912.001]
  • [Cites] Cell. 1998 Jun 12;93(6):1043-53 [9635433.001]
  • [Cites] Biochim Biophys Acta. 1998 Jun 16;1398(2):113-36 [9689912.001]
  • [Cites] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14932-7 [9843993.001]
  • [Cites] Anticancer Res. 1998 Sep-Oct;18(5B):3705-8 [9854481.001]
  • [Cites] J Pathol. 2005 Jan;205(2):123-9 [15643673.001]
  • (PMID = 19293805.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / GMNN protein, human; 0 / Geminin; 0 / Ki-67 Antigen; 0 / Nuclear Proteins; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
  • [Other-IDs] NLM/ PMC2669983
  •  go-up   go-down


6. Soufla G, Baritaki S, Sifakis S, Zafiropulos A, Spandidos DA: Transcriptional inactivation of p53, Bax, Bcl-2 and Mdm2 correlates with malignant transformation of the uterine cervix. Int J Biol Markers; 2005 Jan - Mar;20(1):18-27
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : Deregulation of the apoptotic machinery plays a major role in cell death, cellular transformation and cancer. p53, Bcl-2, Bcl-XL, Bax and Mdm2 mRNA expression patterns were evaluated in tissue samples with cervical intraepithelial neoplasia (CIN) and cervical cancer compared to those of normal cervical tissues, and correlated with the underlying cervical lesions.
  • High-grade squamous intraepithelial lesions exhibited lower p53 and Bcl-2 mRNA levels than controls (p=0.002, p=0.016).

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 28207100.001).
  • [ISSN] 1724-6008
  • [Journal-full-title] The International journal of biological markers
  • [ISO-abbreviation] Int. J. Biol. Markers
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Italy
  •  go-up   go-down


7. Sierra-Torres CH, Acosta-Aragón MP, Orejuela-Aristizabal L: [Papillomavirus and factors associated with high-risk, cervical intraepithelial neoplasia in Cauca, Colombia]. Rev Salud Publica (Bogota); 2006 May;8 Suppl 1:47-58
MedlinePlus Health Information. consumer health - Cervical Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Papillomavirus and factors associated with high-risk, cervical intraepithelial neoplasia in Cauca, Colombia].
  • [Transliterated title] Papilomavirus y factores asociados a neoplasia intraepitelial cervical de alto grado en Cauca, Colombia.
  • OBJECTIVE: Evaluating the role of the main factors associated with high-risk cervical intraepithelial neoplasia in women from the Cauca Department in Colombia.
  • RESULTS: The study confirmed association between HPV and the risk of cervical neoplasia (OR = 19.0; 95% CI = 8.20-44.2).
  • The data suggested that multiparity (OR = 4.1; 95% CI = 1.62-10.6) and exposure to carcinogens present in wood-smoke (OR = 7.3; 95% CI = 3.00-19.4) are important co-factors for cervical neoplasia given the presence of HPV.
  • CONCLUSIONS: These results provide valuable information for public health institutions to develop better cervical neoplasia prevention programmes.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / epidemiology. Papillomaviridae / isolation & purification. Papillomavirus Infections / epidemiology. Uterine Cervical Neoplasms / epidemiology

  • Genetic Alliance. consumer health - Cervical Intraepithelial Neoplasia.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16925121.001).
  • [ISSN] 0124-0064
  • [Journal-full-title] Revista de salud pública (Bogotá, Colombia)
  • [ISO-abbreviation] Rev Salud Publica (Bogota)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Colombia
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal; 0 / DNA Probes, HPV; 0 / Smoke
  •  go-up   go-down


8. Madrigal de la Campa Mde L, Ruiz Moreno JA, Palacios J: [Vulvar intraepithelial neoplasm]. Ginecol Obstet Mex; 2005 Nov;73(11):573-8
MedlinePlus Health Information. consumer health - Vulvar Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vulvar intraepithelial neoplasm].
  • [Transliterated title] Neoplasia intraepitelial de la vulva.
  • BACKGROUND: Vulvar intraepithelial neoplasia is a challenge for the physician as it is asymptomatic and it can evolve to malignant disease.
  • OBJECTIVE: To establish the patient's characteristics with vulvar intraepithelial neoplasia, seen at the Clinica de Especialidades de la Mujer, SEDENA.
  • We identified patients with vulvar intraepithelial neoplasia or in situ vulvar cancer diagnosis.
  • We assessed the following variables: patient's age, intraepithelial neoplasia or history of cervical cancer, acuminated vagina or condylomas, prescribed treatment and current health state.
  • Patients with intraepithelial neoplasia I were the youngest, except one, whom at the moment of the diagnosis had 58 years old.
  • The histopathological diagnosis was of intraepithelial neoplasia type I (koilocytotic atypia) in 10 cases, type II in 10 more, and type III in 18 of them.
  • [MeSH-major] Carcinoma in Situ. Vulvar Neoplasms

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16579162.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
  •  go-up   go-down


9. Kekeeva TV, Zhevlova AI, Podisov IuI, Solov'eva IuV, Zaletataev DV, Nemtsova MV: [Aberrant methylation of tumor suppressor genes and allelic imbalance in cervical intraepitelial neoplasia]. Mol Biol (Mosk); 2006 Mar-Apr;40(2):224-30
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Aberrant methylation of tumor suppressor genes and allelic imbalance in cervical intraepitelial neoplasia].
  • There is no significant difference in methylation frequencies of MGMT and RB1 determined between dysplasia and control.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / genetics. Chromosomes, Human / genetics. DNA Methylation. Genes, Tumor Suppressor. Loss of Heterozygosity / genetics. Uterine Cervical Neoplasms / genetics


10. Pascual Mateo C, Luján Galán M, Rodríguez García N, Llanes González L, Berenguer Sánchez A: [Clinical significance of prostatic intraepithelial neoplasm and atypical small acinar proliferation: relationship with prostate cancer]. Actas Urol Esp; 2008 Jul-Aug;32(7):680-5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical significance of prostatic intraepithelial neoplasm and atypical small acinar proliferation: relationship with prostate cancer].
  • [Transliterated title] Significado clínico de la neoplasia intraepitelial prostática y de la proliferación acinar focal atípica: relación con el cáncer de próstata.
  • INTRODUCTION: Prostatic intraepithelial neoplasia (PIN) and atypical small acinar proliferation (ASAP) in the setting of prostatic needle biopsies are considered premalignant although questions still remain.
  • [MeSH-major] Prostatic Intraepithelial Neoplasia / pathology. Prostatic Neoplasms / pathology

  • Genetic Alliance. consumer health - Prostate cancer.
  • MedlinePlus Health Information. consumer health - Prostate Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18788482.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


11. Arzoz Fábregas M, Areal Calama J, Ibarz Servio L, Gago Ramos JL, Boix Orri R, Saladié Roig JM: [Isolated intraepithelial prostatic neoplasia and positive prostate adenocarcinoma results at repeated biopsy. Review of our series]. Actas Urol Esp; 2005 Sep;29(8):735-8
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Isolated intraepithelial prostatic neoplasia and positive prostate adenocarcinoma results at repeated biopsy. Review of our series].
  • [Transliterated title] Neoplasia intraepitelial prostática aislada y positividad para adenocarcinoma en la rebiopsia. Revision de nuestra serie.
  • OBJECTIVE: To review the incidence of isolated prostatic intraepithelial neoplasia (PIN) as well as the positive prostate cancer results in repeat biopsy in our series of transrectal biopsy of the prostate.
  • MATERIALS AND METHODS: We review the 2.475 transrectal ultrasound guided biopsies of the prostate made in our department from January 1992 to June 2004 looking for intraepithelial neoplasia and looking in particular for isolated High-grade PIN (HGPIN).
  • [MeSH-major] Adenocarcinoma / pathology. Prostatic Intraepithelial Neoplasia / pathology. Prostatic Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Prostate Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16304903.001).
  • [ISSN] 0210-4806
  • [Journal-full-title] Actas urologicas españolas
  • [ISO-abbreviation] Actas Urol Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


12. Lemus-Rocha SR, Andrade-Padilla MA, Rivera-Ibarra DB, Basavilvazo-Rodríguez MA, Hinojosa-Cruz JC, Veloz-Martínez MG: [Clinical aptitude of residents that attend patients with the cervical intraepithelial neoplasia]. Rev Med Inst Mex Seguro Soc; 2009 Nov-Dec;47(6):683-8
International Agency for Research on Cancer - Screening Group. diagnostics - A practical manual on visual screening for cervical neoplasia .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Clinical aptitude of residents that attend patients with the cervical intraepithelial neoplasia].
  • [Transliterated title] Aptitud clínica de médicos residentes en la atención de pacientes con neoplasia intraepitelial cervical.
  • OBJECTIVE: To build, validate and apply an instrument to evaluate the clinical aptitude in intraepitelial cervical neoplasia (ICN) in residents.
  • [MeSH-major] Cervical Intraepithelial Neoplasia. Clinical Competence. Internship and Residency / standards. Uterine Cervical Neoplasms

  • Genetic Alliance. consumer health - Cervical Intraepithelial Neoplasia.
  • MedlinePlus Health Information. consumer health - Cervical Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20602911.001).
  • [ISSN] 0443-5117
  • [Journal-full-title] Revista médica del Instituto Mexicano del Seguro Social
  • [ISO-abbreviation] Rev Med Inst Mex Seguro Soc
  • [Language] spa
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Validation Studies
  • [Publication-country] Mexico
  •  go-up   go-down


13. González Gleason A, Vera Gaspar D, López Castañares C: [Vaginal adenosis and vaginal intraepithelial neoplasia: a review of the literature and a case report]. Ginecol Obstet Mex; 2009 Jul;77(7):329-34
MedlinePlus Health Information. consumer health - Vaginal Diseases.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Vaginal adenosis and vaginal intraepithelial neoplasia: a review of the literature and a case report].
  • [Transliterated title] Adenosis vaginal y neoplasia intraepitelial de vagina: revisión de la bibliografia y reporte de un caso.
  • Vaginal intraepithelial neoplasia (VAIN) is another uncommon condition in women who have not been hysterectomized to treat cervical intraepithelial neoplasia (CIN), with an incidence of 0.3 per 100,000 women.
  • This paper aims at reviewing the literature on vaginal adenosis, vaginal intraepithelial neoplasia and their possible treatments.
  • [MeSH-major] Carcinoma in Situ / complications. Vaginal Diseases / complications. Vaginal Neoplasms / complications

  • MedlinePlus Health Information. consumer health - Vaginal Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19681363.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Mexico
  • [Number-of-references] 13
  •  go-up   go-down


14. Schwartz JD, Christy C, Grube B, Rishi M, Tavassoli F, Bossuyt V, Harris L, DiGiovanna MP, Lannin DR: Histologic subtypes of ductal intraepithelial neoplasia (DIN) of the breast: Characteristic associations and biology. J Clin Oncol; 2009 May 20;27(15_suppl):633

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histologic subtypes of ductal intraepithelial neoplasia (DIN) of the breast: Characteristic associations and biology.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27961448.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


15. Bogoevski D, Schurr PG, Koenig AM, Busch P, Kutup A, Izbicki JR: Is there still place for endoscopic mucosal resection in patients with early oesophageal carcinomas? J Clin Oncol; 2009 May 20;27(15_suppl):e15640

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • None of the 43 patients with high grade intraepithelial neoplasia (HGIEN) or oesophageal carcinoma limited to the mucosa had lymphatic spread, as compared with 15 of 68 (22.1%) with affection of the submucosa.
  • Multifocal neoplasia was detected in three patients with SCC HGIEN (30%) but not in AC HGIEN!
  • Nine out of 44 (20.4%) patients with early SCC had multifocal neoplasia, compared to 6 out of 53 (11.3%) patients in AC (p=0.322).

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27962740.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


16. Seoud MA, Seoud KM, Lindely S, Anis S: Human papilloma virus (HPV): Burden of the disease in cervical cancer in the Extended Middle East and North Africa (EMENA). A comprehensive review. J Clin Oncol; 2009 May 20;27(15_suppl):e16577

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this paper is to review the prevalence of HPV in the general population (GP), in cervical intraepithelial neoplasia (CIN) and in cervical cancer (CCA) in the EMENA.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27961497.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


17. Giannios J, Peristeris J, Alexandropoulos N, Kononas T, Ginopoulos P: Effect on humoral and cellular immunity and on apoptosis in CIN2, CIN3, and HPV16+ cervical cancer of therapeutic divalent genetic vaccination with CMV replicon system (CRS) delivering HPV16 recombinantly mutated E6 and E7 viral oncogenes targeting p53 and Rb, respectively. J Clin Oncol; 2009 May 20;27(15_suppl):3062

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • : 3062 Background: Prophylactic vaccines have no therapeutic capacity for all the women who are already infected with HPV16 and have developed cervical intraepithelial neoplasia (CIN) or cervical cancer.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27962003.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


18. Christy CJ, Rishi M, Schwartz J, Grube BJ, Bossuyt V, Philpotts L, DiGiovanna MP, Tavassoli F, Lannin DR: Association between HER2/neu overexpression and calcifications in breast cancer. J Clin Oncol; 2009 May 20;27(15_suppl):579

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Among 155 cases with histologic calcifications seen within a ductal intraepithelial neoplasia (DIN) component, there were 45 (29%) that were HER-2/neu positive, compared with 67/414 (16%) that did not have calcifications within DIN (p < 0.001).

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 27960749.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


19. Kononov AV: [Interpretation of the notion "dysplasia/ intraepitelial neoplasia" in the international classification of tumors]. Arkh Patol; 2005 Nov-Dec;67(6):44-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Interpretation of the notion "dysplasia/ intraepitelial neoplasia" in the international classification of tumors].
  • Principal definitions are considered, the content of terms "dysplastic" and "neoplasia" is analysed.
  • The attempt to systematize the description of morphological picture of neoplasia (adenoma/dysplasia) of low and high degree and difference of uncertain neoplastic (dysplasia) from true neoplastic changes.
  • [MeSH-major] Digestive System Neoplasms / classification. Terminology as Topic

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16405022.001).
  • [ISSN] 0004-1955
  • [Journal-full-title] Arkhiv patologii
  • [ISO-abbreviation] Arkh. Patol.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Russia (Federation)
  • [Number-of-references] 34
  •  go-up   go-down


20. García-Tamayo J, Molina J, Blasco-Olaetxea E: [Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Review]. Invest Clin; 2009 Jun;50(2):241-50
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Importance of immunohistochemical studies in the diagnosis and the prognostic evaluation of cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Review].
  • [Transliterated title] Importancia de los estudios de inmunohistoquímica en el diagnóstico y la evaluación pronóstica de la neoplasia intraepitelial y el cáncer cervical. Revisión.
  • Immunohistochemical studies in cervical intraepithelial neoplasia and cervical carcinoma are evaluated in this review.
  • A variety of proteins like p53, bcl2, C-Myc, Ki 67, Cyclines, P16 INK4a, p21, p27, beta-catenin, Wnt and MCM, have been related to the development of cervical neoplasia and human papilloma virus infection.
  • It is described how transcriptional factors of genes induce loss of heterozygosity, numerical chromosome abnormality and inactivation of gene products or the partial loss of some membrane glycoproteins induced by oncogenic human papillomaviruses (HPV).
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / diagnosis. Cervical Intraepithelial Neoplasia / diagnosis. Uterine Cervical Neoplasms / diagnosis
  • [MeSH-minor] Blood Group Antigens / analysis. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Gene Expression Regulation, Viral. Genes, Neoplasm. Genes, Viral. Humans. Mutation. Neoplasm Proteins / analysis. Oncogene Proteins, Viral / analysis. Papillomaviridae / classification. Papillomaviridae / genetics. Papillomaviridae / isolation & purification. Papillomaviridae / pathogenicity. Papillomavirus Infections / diagnosis. Papillomavirus Infections / pathology. Prognosis


21. Charúa-Guindic L, Esquivel-Ocampo EA, Villanueva-Herrero JA, Jiménez-Bobadilla B, Muñoz-Cortés SB, Leal-Tamez M, Avendaño-Espinosa O: [Anal intraepithelial neoplasia (NIA) and infection with human papillomavirus (HPV) in anoreceptive patients]. Rev Gastroenterol Mex; 2009;74(3):195-201
MedlinePlus Health Information. consumer health - Anal Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Anal intraepithelial neoplasia (NIA) and infection with human papillomavirus (HPV) in anoreceptive patients].
  • [Transliterated title] La neoplasia intraepitelial anal y la infección por virus del papiloma humano en pacientes anorreceptivos.
  • BACKGROUND: An association between human papilloma virus (HPV) infection and progression to anal intraepithelial neoplasia (AIN) and epidermoid cancer has been established.
  • Anal cytology showed inflammatory alterations in 21 patients (28%), low grade intraepithelial lesion in 23 (52%); there were not patients with high grade epithelial lesion.
  • According to the high definition anoscopy, there were low grade intraepithelial lesion in 42 patients (95%) and high grade in 2 (5%).
  • Biopsy showed low grade intraepithelial in 26 patients (59%), high grade in 4 (9%) and inflammatory alterations in 14 (32%).
  • [MeSH-major] Anus Neoplasms / complications. Carcinoma in Situ / complications. Papillomavirus Infections / complications. Sexual Behavior / statistics & numerical data

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19858007.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
  •  go-up   go-down


22. Salazar EL, González JL, Olmos A, Calzada L: [Influence of the use of oral contraceptives as risk factors for human papillomavirus infection and cervical intraepithelial neoplasia]. Ginecol Obstet Mex; 2005 Feb;73(2):83-9
MedlinePlus Health Information. consumer health - Cervical Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Influence of the use of oral contraceptives as risk factors for human papillomavirus infection and cervical intraepithelial neoplasia].
  • [Transliterated title] Influencia del uso de anticonceptivos orales como factores de riesgo para infección por virus del papiloma humano y neoplasia intraepitelial cervical.
  • OBJECTIVE: To study the influence of oral contraception use as risk factor for human papillomavirus infection (HPV) and progression to cervical intraepithelial neoplasia (CIN).
  • [MeSH-major] Cervical Intraepithelial Neoplasia / epidemiology. Contraceptives, Oral, Hormonal. Papillomavirus Infections / epidemiology. Uterine Cervical Neoplasms / epidemiology

  • Genetic Alliance. consumer health - Cervical Intraepithelial Neoplasia.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 21961342.001).
  • [ISSN] 0300-9041
  • [Journal-full-title] Ginecología y obstetricia de México
  • [ISO-abbreviation] Ginecol Obstet Mex
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Mexico
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal
  •  go-up   go-down


23. Takeda T, Sugihara K, Hirayama Y, Hirano M, Tanuma JI, Semba I: Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias. J Oral Pathol Med; 2006 Jul;35(6):369-75
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistological evaluation of Ki-67, p63, CK19 and p53 expression in oral epithelial dysplasias.
  • BACKGROUND: Oral squamous cell carcinoma develops through a multistep of genetic mutations, and the process can be morphologically recognized as oral epithelial dysplasia.
  • To evaluate the hypothesis that distributional alterations of proliferating and stem cells may be a useful index to estimate the grading and development of epithelial dysplasia, we examined the distribution patterns according to stratified cell layers.
  • METHODS: Sixty-two oral dysplasia cases according to the histological grades were immunohistologically examined and the nuclear expression of Ki-67 and p63 antigens was counted according to epithelial layers as labeling index.
  • RESULTS: The Ki-67 labeling index in the basal and suprabasal layers and that of p63 in the basal layer showed a significant difference between low- and high-grade groups of epithelial dysplasia.
  • CONCLUSION: The architectural alteration of proliferating cell and stem cell distribution in the layers of epithelial dysplasias may provide useful information to evaluate the grading of oral epithelial dysplasias.
  • [MeSH-major] Mouth Neoplasms / metabolism. Neoplasm Proteins / biosynthesis. Neoplastic Stem Cells / metabolism. Precancerous Conditions / metabolism

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • COS Scholar Universe. author profiles.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16762018.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Ki-67 Antigen; 0 / Membrane Proteins; 0 / Neoplasm Proteins; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
  •  go-up   go-down


24. Laria-Ochaita C, Alió-y-Sanz JL: [Corneal intra-epithelial neoplasia (CIN). Treatment by combined excision and antimetabolite therapy]. Arch Soc Esp Oftalmol; 2005 Nov;80(11):671-4
Hazardous Substances Data Bank. MITOMYCIN C .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Corneal intra-epithelial neoplasia (CIN). Treatment by combined excision and antimetabolite therapy].
  • [Transliterated title] Neoplasia intraepitelial corneal (CIN). Tratamiento mediante exéresis y antimetabolitos.
  • CASE REPORT: We present two clinical cases of corneal intra-epithelial neoplasia defined histopathologically.
  • DISCUSSION: We sought to establish the importance of treatment with Mitomycin-C in two cases of corneal intra-epithelial neoplasia.
  • [MeSH-major] Carcinoma in Situ / therapy. Corneal Diseases / therapy. Eye Neoplasms / therapy

  • MedlinePlus Health Information. consumer health - Corneal Disorders.
  • MedlinePlus Health Information. consumer health - Eye Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16311958.001).
  • [ISSN] 0365-6691
  • [Journal-full-title] Archivos de la Sociedad Española de Oftalmología
  • [ISO-abbreviation] Arch Soc Esp Oftalmol
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 50SG953SK6 / Mitomycin
  •  go-up   go-down


25. Lauwers GY, Srivastava A: Gastric preneoplastic lesions and epithelial dysplasia. Gastroenterol Clin North Am; 2007 Dec;36(4):813-29, vi
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric preneoplastic lesions and epithelial dysplasia.
  • This article describes gastric preneoplastic lesions and epithelial dysplasia.
  • [MeSH-major] Gastric Mucosa / pathology. Gastritis / pathology. Precancerous Conditions / pathology. Stomach Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Stomach Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17996792.001).
  • [ISSN] 0889-8553
  • [Journal-full-title] Gastroenterology clinics of North America
  • [ISO-abbreviation] Gastroenterol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 135
  •  go-up   go-down


26. Bradley G, Odell EW, Raphael S, Ho J, Le LW, Benchimol S, Kamel-Reid S: Abnormal DNA content in oral epithelial dysplasia is associated with increased risk of progression to carcinoma. Br J Cancer; 2010 Oct 26;103(9):1432-42
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Abnormal DNA content in oral epithelial dysplasia is associated with increased risk of progression to carcinoma.
  • BACKGROUND: Oral epithelial dysplasia (OED) is a histologically detectable lesion that may progress to carcinoma but there are no accurate markers that predict progression.
  • METHODS: Epithelial dysplasias from the Oral Pathology Diagnostic Service were matched against the Ontario Cancer Registry database to identify cases that progressed to carcinoma.
  • A case-control study was conducted to compare DNA image cytometry of dysplasias that progressed with those that have not progressed.
  • For a subset of the progressed dysplasias, DNA content of the carcinoma was also analysed.
  • RESULTS: A total of 8% of epithelial dysplasias progressed to carcinoma after 6-131 months.
  • In all, 28 of 99 dysplasias showed abnormal DNA content by image cytometry.
  • In multivariate analysis of time to progression, abnormal DNA content was a significant predictor with hazard ratio of 3.3 (95% confidence interval: 1.5-7.4) corrected for site and grade of dysplasia.
  • Analysis of sequential samples of dysplasia and carcinoma suggested that epithelial cell populations with grossly abnormal DNA content were transient intermediates during oral cancer development.
  • [MeSH-major] DNA, Neoplasm / ultrastructure. Disease Progression. Mouth Mucosa / pathology. Mouth Neoplasms / genetics. Precancerous Conditions / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer Res. 2008 May 1;68(9):3099-107 [18451134.001]
  • [Cites] J Oral Pathol Med. 2008 Mar;37(3):127-33 [18251935.001]
  • [Cites] J Cell Sci. 2008 Dec 1;121(Pt 23):3859-66 [19020304.001]
  • [Cites] Oral Oncol. 2009 Jun;45(6):468-73 [18805043.001]
  • [Cites] Hum Mol Genet. 2009 Dec 15;18(24):4818-29 [19776030.001]
  • [Cites] J Oral Pathol Med. 2008 Jan;37(1):1-10 [18154571.001]
  • [Cites] Clin Cancer Res. 2000 Feb;6(2):357-62 [10690511.001]
  • [Cites] Cancer Res. 2000 Jul 15;60(14):3893-8 [10919665.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):603-9 [11401909.001]
  • [Cites] Am J Gastroenterol. 2001 Nov;96(11):3071-83 [11721752.001]
  • [Cites] Anal Cell Pathol. 2001;23(2):89-95 [11904464.001]
  • [Cites] Crit Rev Oral Biol Med. 2003;14(1):47-62 [12764019.001]
  • [Cites] Clin Cancer Res. 2004 Oct 1;10(19):6460-5 [15475433.001]
  • [Cites] Cancer Res. 2004 Oct 15;64(20):7629-33 [15492292.001]
  • [Cites] Methods Cell Biol. 1994;41:231-40 [7861965.001]
  • [Cites] Pathologica. 1995 Jun;87(3):286-99 [8570289.001]
  • [Cites] Cancer Res. 1996 Jun 1;56(11):2488-92 [8653682.001]
  • [Cites] Nat Med. 1996 Jun;2(6):682-5 [8640560.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7081-4 [8692948.001]
  • [Cites] J Pathol. 1998 Apr;184(4):360-8 [9664901.001]
  • [Cites] Oral Oncol. 1998 Jul;34(4):270-5 [9813722.001]
  • [Cites] Nat Rev Cancer. 2005 Feb;5(2):127-35 [15685196.001]
  • [Cites] Oral Oncol. 2005 Apr;41(4):416-22 [15792614.001]
  • [Cites] Carcinogenesis. 2006 Feb;27(2):337-43 [16123119.001]
  • [Cites] Oral Oncol. 2006 May;42(5):461-74 [16316774.001]
  • [Cites] N Engl J Med. 2006 Nov 2;355(18):1927 [17079770.001]
  • [Cites] Oral Oncol. 2007 Mar;43(3):310-6 [16931117.001]
  • [Cites] Curr Opin Genet Dev. 2007 Apr;17(2):157-62 [17324569.001]
  • [Cites] J Oral Pathol Med. 2007 Nov;36(10):575-80 [17944749.001]
  • [Cites] Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2174-9 [18708411.001]
  • (PMID = 20859287.001).
  • [ISSN] 1532-1827
  • [Journal-full-title] British journal of cancer
  • [ISO-abbreviation] Br. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm
  • [Other-IDs] NLM/ PMC2990600
  •  go-up   go-down


27. Drewa T, Wolski Z, Skok Z, Czajkowski R, Wiśniewska H: The FAS-related apoptosis signaling pathway in the prostate intraepithelial neoplasia and cancer lesions. Acta Pol Pharm; 2006 Jul-Aug;63(4):311-5
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The FAS-related apoptosis signaling pathway in the prostate intraepithelial neoplasia and cancer lesions.
  • An aim of the study was to determine the protein expression of the FAS-related apoptosis signaling pathway (FADD-FAS Associating Protein with Death Domain, PRO-CASPASE-8 and CASPASE-8), which are responsible for signal transduction to trigger programmed cell death (apoptosis) in cancer and Prostatic Intraepitelial Neoplasia (PIN).
  • [MeSH-major] Antigens, CD95 / physiology. Apoptosis / physiology. Prostatic Neoplasms / pathology. Signal Transduction / physiology

  • Genetic Alliance. consumer health - Prostate cancer.
  • MedlinePlus Health Information. consumer health - Prostate Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17203870.001).
  • [ISSN] 0001-6837
  • [Journal-full-title] Acta poloniae pharmaceutica
  • [ISO-abbreviation] Acta Pol Pharm
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Antigens, CD95; EC 3.4.22.- / Caspase 8
  •  go-up   go-down


28. Goldstein NS: Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol; 2006 Jan;125(1):132-45
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases.
  • Eight sessile serrated adenoma (SSA), right colon polypectomies with focal invasive adenocarcinoma or high-grade dysplasia were studied to identify features indicating a high risk of transformation and characterize the morphologic features of serrated dysplasia; 6 cases had invasive adenocarcinoma; 2 were high-grade dysplasia.
  • In the 6 invasive adenocarcinomas, the neoplasm extended directly down into the submucosa without lateral intramucosal spread.
  • All 8 cases had high-grade serrated-type dysplasia.
  • Small proximal SSAs can transform into adenocarcinoma without a component of adenomatous dysplasia.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Chromosomal Instability. Colonic Neoplasms / pathology. Microsatellite Repeats

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16483002.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins
  •  go-up   go-down


29. Torres-Rendon A, Stewart R, Craig GT, Wells M, Speight PM: DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression. Oral Oncol; 2009 Jun;45(6):468-73
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression.
  • Abnormal DNA content (aneuploidy) has been associated with malignant and premalignant epithelial lesions.
  • Forty-two lesions of oral epithelial dysplasias (OED) that had progressed to oral squamous cell carcinoma (OSCC) and 44 lesions that did not progress were analysed for DNA ploidy using image cytometry of nuclear monolayers prepared from paraffin-embedded tissue.
  • [MeSH-major] Aneuploidy. Carcinoma, Squamous Cell / genetics. Mouth Mucosa / pathology. Mouth Neoplasms / genetics. Mouth Neoplasms / pathology. Precancerous Conditions / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Case-Control Studies. Female. Great Britain. Humans. Image Cytometry / methods. Male. Middle Aged. Neoplasm Staging. Prognosis. Retrospective Studies. Risk Assessment. Sensitivity and Specificity

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18805043.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  •  go-up   go-down


30. Kawczyk-Krupka A, Ledwon A, Malyszek J, Sieron A: Balanoposthitis with epithelial dysplasia treated by photodynamic therapy. Photodiagnosis Photodyn Ther; 2007 Mar;4(1):76-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Balanoposthitis with epithelial dysplasia treated by photodynamic therapy.
  • OBJECTIVE: We present the case of 50-year-old male with balanoposthitis associated with epithelial dysplasia treated by topical aminolaevulinic acid photodynamic therapy.
  • CONCLUSION: Photodynamic therapy appears to be an alternative, non-invasive, well tolerated method of treatment of eithelial dysplasia of the penis.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 25047196.001).
  • [ISSN] 1572-1000
  • [Journal-full-title] Photodiagnosis and photodynamic therapy
  • [ISO-abbreviation] Photodiagnosis Photodyn Ther
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  •  go-up   go-down


31. Sousa FA, Paradella TC, Carvalho YR, Rosa LE: Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia. J Oral Sci; 2009 Mar;51(1):117-21
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia.
  • The expression of proteins related to cell proliferation and apoptosis in oral lichen planus and epithelial dysplasia was analyzed to evaluate the true potential for malignant transformation of this disease.
  • Of the 24 cases of oral lichen planus, 14 (58.33%) were positive for PCNA, 10 (41.67%) for p53, 4 (16.67%) for bcl-2 and 12 (50%) for bax, whereas of the 24 cases of epithelial dysplasia, 20 (83.33%) were positive for PCNA, 10 (41.67%) for p53, 6 (25%) for bcl-2, and 20 (83.33%) for bax.
  • Chi-squared test showed no statistically significant differences between the expression of p53 and bcl-2 in oral lichen planus and epithelial dysplasia, regardless of the grade (P > 0.05).
  • However, the expression of PCNA and bax was significantly increased in epithelial dysplasia (P < 0.05).
  • The results of this study showed that alterations in expression of these proteins are observed in oral lichen planus and epithelial dysplasia, suggesting the potential for malignant transformation in both lesions.
  • [MeSH-major] Lichen Planus, Oral / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology. Proliferating Cell Nuclear Antigen / analysis. Proto-Oncogene Proteins c-bcl-2 / analysis. Tumor Suppressor Protein p53 / analysis. bcl-2-Associated X Protein / analysis

  • Genetic Alliance. consumer health - Oral lichen planus.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19325208.001).
  • [ISSN] 1343-4934
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / BAX protein, human; 0 / Coloring Agents; 0 / Proliferating Cell Nuclear Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / Tumor Suppressor Protein p53; 0 / bcl-2-Associated X Protein
  •  go-up   go-down


32. de Sousa FA, Paradella TC, Carvalho YR, Rosa LE: Comparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal; 2009 Nov;14(11):e563-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma.
  • AIM: To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indicate the potential for malignant transformation.
  • RESULTS: Positivity for PCNA was observed in 58.33% of oral lichen planus cases, 83.33% of epithelial dysplasia cases and 91.67% of oral squamous cell carcinoma cases.
  • No significant statistical difference between oral lichen planus and epithelial dysplasia (p>0.05) and between the epithelial dysplasia and oral squamous cell carcinoma (p>0.05) was observed.
  • The mean NORs/nucleus in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma were 1.74+/-0.32, 2.42+/-0.62 e 2.41+/-0.61, respectively.
  • CONCLUSION: Oral lichen planus cell proliferation rate was less than in oral epithelial dysplasia and oral squamous cell carcinoma which might explain the lower malignant transformation rate.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Cell Proliferation. Lichen Planus, Oral / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology


33. Syafriadi M, Cheng J, Jen KY, Ida-Yonemochi H, Suzuki M, Saku T: Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells. J Oral Pathol Med; 2005 Mar;34(3):140-9
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two-phase appearance of oral epithelial dysplasia resulting from focal proliferation of parabasal cells and apoptosis of prickle cells.
  • BACKGROUND: One of the histologic characteristics of epithelial dysplasias of the oral mucosa is droplet-shaped rete processes resulting from a solid proliferation of basaloid cells.
  • However, in epithelial dysplasias, apoptotic cells were scattered in the middle or even in the lower parts of the epithelial layer with frequent vacuolation changes of epithelial cells.
  • Within the epithelial layer of dysplasias, there were increased number of lymphocytes, which were immunopositive for CD45RO, CD8, and CD57- and CD68-immunopositive (+), S-100 protein-positive and major histocompatibility complex (MHC) class II-positive monocytic lineages.
  • They increased in number with the severity of dysplastic degrees, and they were often located in the vicinity of apoptotic epithelial cells, but decreased in carcinomas in situ and invasive carcinomas, which contained fewer numbers of apoptotic figures.
  • CONCLUSION: The findings indicate that intraepithelial infiltrations of both cytotoxic T cells and natural killer cells are closely related to the apoptotic phenomena of prickle cells, which may result in the characteristic 'two-phase appearance' of epithelial dysplasia.
  • [MeSH-major] Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Apoptosis. CD8-Positive T-Lymphocytes / pathology. Carcinoma in Situ / pathology. Carcinoma, Squamous Cell / pathology. Cell Proliferation. Cell Transformation, Neoplastic / pathology. Epithelial Cells / classification. Epithelial Cells / pathology. Histocompatibility Antigens Class II / analysis. Humans. Hyperplasia. Killer Cells, Natural / pathology. Lymphocyte Subsets / pathology. Macrophages / pathology. Monocytes / pathology. Neoplasm Invasiveness. Parakeratosis / pathology. S100 Proteins / analysis. T-Lymphocytes, Cytotoxic / pathology. Vacuoles / ultrastructure

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15689227.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Histocompatibility Antigens Class II; 0 / S100 Proteins
  •  go-up   go-down


34. Neppelberg E, Johannessen AC: DNA content, Cyclooxygenase-2 expression and loss of E-cadherin expression do not predict risk of malignant transformation in oral lichen planus. Eur Arch Otorhinolaryngol; 2007 Oct;264(10):1223-30
Genetic Alliance. consumer health - Oral lichen planus.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Using cases which had transformed, and those which had not, this study aimed to evaluate the potential of DNA content, expression of Cyclooxygenase-2 (Cox-2) and of epithelial (E)-cadherin as risk markers in lesions of OLP.
  • (1) 26 OLP patients with at least two biopsies, of whom seven presented OLP with epithelial dysplasia, followed by oral squamous cell carcinoma (OSCC) in five of them, (2) 19 OLP patients with one biopsy taken.
  • All OLP biopsies investigated were classified as diploid, one OLP with epithelial dysplasia was tetraploid and all OSCC were diploid.
  • Cox-2 was detected in the epithelium of all OLP specimens investigated, as well as in epithelial dysplasias and OSCC.
  • Focal loss of E-cadherin expression was observed in basal keratinocytes in 88% of the OLP specimens investigated, in all epithelial dysplasias and OSCC.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17530268.001).
  • [ISSN] 0937-4477
  • [Journal-full-title] European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
  • [ISO-abbreviation] Eur Arch Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cadherins; EC 1.14.99.1 / Cyclooxygenase 2
  •  go-up   go-down


35. Buonomo O, Orsaria P, Contino G, Varvaras D, Gioia A, Bonanno E, Pistolese C, Cossu E, Perretta T, Schillaci O, Del Monte G, Roselli M, Mineo TC, Petrella G: Pathological classification of DCIS and planning of therapeutic management. Anticancer Res; 2009 May;29(5):1499-506
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Ductal intraepitelial neoplasia (DIN) represents a spectrum of disease that may progress from usual hyperplasia to ductal carcinoma in situ (DCIS) grade 3.
  • [MeSH-major] Breast Neoplasms / classification. Carcinoma, Intraductal, Noninfiltrating / classification

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19443357.001).
  • [ISSN] 0250-7005
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  •  go-up   go-down


36. Ponniah I: A rare case of sialadenoma papilliferum with epithelial dysplasia and carcinoma in situ. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2007 Aug;104(2):e27-9
MedlinePlus Health Information. consumer health - Salivary Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A rare case of sialadenoma papilliferum with epithelial dysplasia and carcinoma in situ.
  • The present article reports a rare case of sialadenoma papilliferum with epithelial dysplasia and carcinoma-in-situ in the exophytic component.
  • [MeSH-major] Carcinoma in Situ / pathology. Mouth Floor / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology. Salivary Gland Neoplasms / pathology
  • [MeSH-minor] Adult. Cell Transformation, Neoplastic. Epithelial Cells / pathology. Humans. Male. Rare Diseases

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17630095.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  •  go-up   go-down


37. Zhao J, Guo B, Ma SC, Zhou XD: [Expression of p53 and Ki-67 genes in epithelial dysplasia from old oral mucosa and clinical significance]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2005 Sep;36(5):689-91
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Expression of p53 and Ki-67 genes in epithelial dysplasia from old oral mucosa and clinical significance].
  • OBJECTIVE: To elucidate the relationship between the malignant transformation of oral epithelial dysplasia and the expression of p53 and Ki-67 proteins.
  • METHODS: The expression of p53 and Ki-67 proteins from 60 cases of oral epithelial dysplasia (28 cases of mild epithelial dysplasia, 32 cases of severe epithelial dysplasia) and 30 normal oral mucosa tissue was determined by immunihistochemistry, and a 5-year follow-up study was made.
  • In the cases of mild epithelial dysplasia, low levels of Ki-67 and p53 expression were detected.
  • In the cases of severe epithelial dysplasia, the expression of p53 and Ki-67 protein was significantly higher than that in the normal oral mucosa and in the mild epithelial cases (P < 0.05).
  • There was a correlation between the malignant transformation and the mutation of p53, Ki-67 in the cases of oral epithelial dysplasia.
  • [MeSH-major] Ki-67 Antigen / biosynthesis. Mouth Neoplasms / genetics. Precancerous Conditions / genetics. Tumor Suppressor Protein p53 / biosynthesis

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16235539.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53
  •  go-up   go-down


38. Uehara M, Ikeda H, Nonaka M, Asahina I: Histopathological change of oral malignant tumour and epithelial dysplasia subjected to photodynamic therapy. J Oral Maxillofac Res; 2010;1(3):e5
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histopathological change of oral malignant tumour and epithelial dysplasia subjected to photodynamic therapy.
  • OBJECTIVES: The purpose of this study is to analyze the morphological change of cell nuclei and the change of proliferating activity of oral malignancy and epithelial dysplasia between before and after photodynamic therapy in order to predict recurrence.
  • MATERIAL AND METHODS: We experienced 14 cases of oral squamous cell carcinoma, one case of verrucous carcinoma and seven cases of epithelial dysplasia treated by photodynamic therapy (PDT).
  • CONCLUSIONS: Mean nuclear area in the biopsy specimen after photodynamic therapy is likely to be a predictive marker for the recurrence of oral squamous cell carcinoma or epithelial dysplasia subjected to photodynamic therapy, while coefficient of variation of the nuclear area and proliferating cell nuclear antigen labelling indices are less helpful in predicting the recurrence of such lesions.

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 24421975.001).
  • [ISSN] 2029-283X
  • [Journal-full-title] Journal of oral & maxillofacial research
  • [ISO-abbreviation] J Oral Maxillofac Res
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Lithuania
  • [Other-IDs] NLM/ PMC3886051
  • [Keywords] NOTNLM ; cell nucleus / epithelial cells / photodynamic therapy / proliferating cell nuclear antigen. / squamous cell carcinoma / verrucous carcinoma
  •  go-up   go-down


39. Watanabe S, Sato K, Okazaki Y, Tonogi M, Tanaka Y, Yamane GY: Activation of PI3K-AKT pathway in oral epithelial dysplasia and early cancer of tongue. Bull Tokyo Dent Coll; 2009 Aug;50(3):125-33
Genetic Alliance. consumer health - Tongue cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Activation of PI3K-AKT pathway in oral epithelial dysplasia and early cancer of tongue.
  • Samples of normal epithelium, epithelial dysplasia, and cancer tissues were collected by laser microdissection, RNA was extracted, and the signals converted to numerical values.
  • Five genes showed a 2 times or greater level of increase in expression in epithelial tissue in comparison with in normal tissue, while 4 genes showed a 2 times or greater increase in early cancer tissues.
  • In cancer tissues and epithelial dysplasia tissues, PI3K class III was expressed at 2.5 times and 11 times the level of that found in normal tissue, respectively.
  • Positive cells were noted in the basal and parabasal cell layers, and partially in the spinous layer of epithelial dysplasia tissues, and in the spinous layer of early cancer tissues.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Leukoplakia, Oral / metabolism. Phosphatidylinositol 3-Kinases / biosynthesis. Proto-Oncogene Proteins c-akt / metabolism. Tongue Neoplasms / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Early Detection of Cancer. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Gene Expression Profiling. Gene Expression Regulation, Neoplastic. Humans. Immunoenzyme Techniques. Male. Microdissection. Middle Aged. Oligonucleotide Array Sequence Analysis. Proto-Oncogene Proteins c-bcl-2 / biosynthesis. Signal Transduction

  • Genetic Alliance. consumer health - Oral cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19887755.001).
  • [ISSN] 0040-8891
  • [Journal-full-title] The Bulletin of Tokyo Dental College
  • [ISO-abbreviation] Bull. Tokyo Dent. Coll.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / BCL2-related protein A1; 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 2.7.11.1 / Proto-Oncogene Proteins c-akt
  •  go-up   go-down


40. Chen YK, Hsue SS, Lin LM: Expression of p63 protein and mRNA in oral epithelial dysplasia. J Oral Pathol Med; 2005 Apr;34(4):232-9
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of p63 protein and mRNA in oral epithelial dysplasia.
  • The aim of the present study was to investigate the expression of p63 protein and mRNA in oral epithelial dysplasia.
  • METHODS: Immunohistochemical p63 staining was compared for samples from 90 male patients with buccal epithelial dysplasias and 15 healthy individuals with normal buccal mucosa and 15 subjects with reactive epithelial hyperplasia of the oral mucosa secondary to traumatic insult.
  • The buccal lesions consisted of mild, moderate and severe epithelial dysplasias (30 samples in each category).
  • The mRNA expression using reverse transcription polymerase chain reaction (RT-PCR) was also included for a subset of available fresh tissue specimens (four samples in each category of mild and moderate epithelial dysplasia; five samples in severe epithelial dysplasia; five samples in each of normal and reactive epithelial hyperplasia).
  • RESULTS: Nuclear p63 staining was demonstrated predominantly in the basal layers of the epithelium of the normal buccal mucosa and reactive epithelial hyperplasia specimens.
  • For epithelial dysplasia lesions, however, staining was not restricted to the basal layers, extending to the middle spinous layer for samples in the mild category, with p63 immunoexpression observed across almost the full thickness of the dysplastic epithelium for analogous moderate and severe specimens.
  • The severity of dysplasia was increased with the increase of p63 staining.
  • A subset of moderate epithelial dysplasia and severe variant showing p63-positive staining has undergone malignant transformation to squamous cell carcinomas in about 5 years follow-up.
  • CONCLUSION: Our results indicate that impaired p63 immunoexpression (predominantly Delta N isoform) is associated with the severity of oral epithelial dysplasias and up-regulation of p63 may play a role in the early stage of human oral tumorigenesis.
  • [MeSH-minor] Adult. Aged. Carcinoma, Squamous Cell / pathology. Cell Nucleus / ultrastructure. Cell Transformation, Neoplastic / pathology. Coloring Agents. DNA-Binding Proteins. Epithelium / metabolism. Epithelium / pathology. Follow-Up Studies. Genes, Tumor Suppressor. Humans. Hyperplasia. Male. Middle Aged. Mouth Neoplasms / pathology. Protein Isoforms / analysis. Reverse Transcriptase Polymerase Chain Reaction. Transcription Factors

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15752259.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / DNA-Binding Proteins; 0 / Phosphoproteins; 0 / Protein Isoforms; 0 / RNA, Messenger; 0 / TP63 protein, human; 0 / Trans-Activators; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins
  •  go-up   go-down


41. Ankle MR, Kale AD, Charantimath S: Comparison of staining of mitotic figures by haematoxylin and eosin-and crystal violet stains, in oral epithelial dysplasia and squamous cell carcinoma. Indian J Dent Res; 2007 Jul-Sep;18(3):101-5
Hazardous Substances Data Bank. Gentian Violet .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Comparison of staining of mitotic figures by haematoxylin and eosin-and crystal violet stains, in oral epithelial dysplasia and squamous cell carcinoma.
  • 2) To compare the number of mitotic figures present in normal oral mucosa, epithelial dysplasia and oral squamous cell carcinoma in crystal violet-stained sections with that in H and E-stained sections.
  • MATERIALS AND METHODS: Ten tissues of normal oral mucosa and 15 tissues each of oral epithelial dysplasia seen in tobacco-associated leukoplakia and squamous cell carcinoma were studied to evaluate the selectivity of 1% crystal violet for mitotic figures.
  • RESULTS: A statistically significant increase in the mean mitotic count was observed in crystal violet-stained sections of epithelial dysplasia as compared to the H and E-stained sections (p=0.0327).
  • No significant difference was found in the mitotic counts determined in dysplasia or carcinoma by either the crystal violet (p=0.4429) or the H and E-staining techniques (p=0.2717).
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Mitosis / physiology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology. Staining and Labeling / methods

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • Genetic Alliance. consumer health - Oral squamous cell carcinoma.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • Hazardous Substances Data Bank. HEMATOXYLIN .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17687171.001).
  • [ISSN] 0970-9290
  • [Journal-full-title] Indian journal of dental research : official publication of Indian Society for Dental Research
  • [ISO-abbreviation] Indian J Dent Res
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] India
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Fluorescent Dyes; J4Z741D6O5 / Gentian Violet; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
  •  go-up   go-down


42. Etemad-Moghadam S, Khalili M, Tirgary F, Alaeddini M: Evaluation of myofibroblasts in oral epithelial dysplasia and squamous cell carcinoma. J Oral Pathol Med; 2009 Sep;38(8):639-43
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of myofibroblasts in oral epithelial dysplasia and squamous cell carcinoma.
  • The purpose of this study was to evaluate and compare the presence of myofibroblasts in normal mucosa, oral epithelial dysplasia, and different grades of oral squamous cell carcinoma.
  • METHODS: The study sample consisted of three groups, including 40 oral squamous cell carcinomas, 15 dysplasias, and 15 sections of normal oral epithelium.
  • RESULTS: The percentage and intensity of alpha-smooth muscle actin were examined, and positive immunostaining was observed in the myofibroblasts of all squamous cell carcinomas; however these cells did not stain in the dysplasias or normal epithelium specimens.
  • The presence of myofibroblasts was significantly higher in oral squamous cell carcinomas compared to both, dysplasias and normal mucosa cases (P < 0.001).
  • CONCLUSIONS: These findings show the presence of myofibroblasts in the stroma of oral squamous cell carcinoma but not dysplasia and normal mucosa, suggesting further investigation to clarify the role of myofibroblasts in the carcinogenesis of this tumor.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Fibroblasts / cytology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Muscle Cells / cytology. Precancerous Conditions / pathology

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • Genetic Alliance. consumer health - Oral squamous cell carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19473444.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Actins; 0 / Desmin; 0 / Vimentin
  •  go-up   go-down


43. Seifi S, Shafaei SN, Nosrati K, Ariaeifar B: Lack of elevated HER2/neu expression in epithelial dysplasia and oral squamous cell carcinoma in Iran. Asian Pac J Cancer Prev; 2009 Oct-Dec;10(4):661-4
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lack of elevated HER2/neu expression in epithelial dysplasia and oral squamous cell carcinoma in Iran.
  • MATERIALS AND METHODS: Expression of HER2/neu oncoprotein in OSCCs (N= 18), oral epithelial dysplasia (N= 18) and normal oral mucosa (N= 18) was assessed by immunohistochemistry using a cerbB2 antibody kit.
  • In oral epithelial dysplasia, 2/18 (11.1%) demonstrated staining, as did 3/18 OSCCs.
  • Membrane staining was observed in all cases and there was no significant variation in frequency/intensity between normal oral mucosa / oral epithelial dysplasia and OSCCs (p>0.05).
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Mouth Mucosa / metabolism. Mouth Neoplasms / metabolism. Precancerous Conditions / metabolism. Receptor, ErbB-2 / metabolism
  • [MeSH-minor] Humans. Immunoenzyme Techniques. Iran. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Up-Regulation


44. Seoane JM, Varela-Centelles PI, Ramirez JR, Cameselle-Teijeiro J, Romero MA, Aguirre JM: Heat shock proteins (HSP70 and HSP27) as markers of epithelial dysplasia in oral leukoplakia. Am J Dermatopathol; 2006 Oct;28(5):417-22
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Heat shock proteins (HSP70 and HSP27) as markers of epithelial dysplasia in oral leukoplakia.
  • HSP70 and HSP27 are constitutively and gradually expressed in a broad range of normal tissues and neoplasms, and their expression has been assessed as markers for oral epithelial dysplasia.
  • The presence of epithelial dysplasia and its histologic grading was evaluated according to the World Health Organization classification: mild, moderate, and severe squamous epithelial dysplasia.
  • No significant difference for HSP27 cytoplasmic expression could be identified between OL with or without epithelial dysplasia(Equation is included in full-text article.
  • It is concluded that the nuclear HSP70 immunoexpression could be an objective marker for the presence of the epithelial dysplasia in OL.

  • Genetic Alliance. consumer health - Leukoplakia.
  • Genetic Alliance. consumer health - Oral leukoplakia.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17012917.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Biomarkers; 0 / HSP70 Heat-Shock Proteins; 0 / Heat-Shock Proteins
  •  go-up   go-down


45. Ralhan R, Desouza LV, Matta A, Chandra Tripathi S, Ghanny S, Dattagupta S, Thakar A, Chauhan SS, Siu KW: iTRAQ-multidimensional liquid chromatography and tandem mass spectrometry-based identification of potential biomarkers of oral epithelial dysplasia and novel networks between inflammation and premalignancy. J Proteome Res; 2009 Jan;8(1):300-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] iTRAQ-multidimensional liquid chromatography and tandem mass spectrometry-based identification of potential biomarkers of oral epithelial dysplasia and novel networks between inflammation and premalignancy.
  • Isobaric mass tags (iTRAQ)-labeled oral dysplasias and normal tissues were compared against pooled normal control by online liquid chromatography and tandem mass spectrometry.
  • A panel of three best-performing biomarkers identified by iTRAQ analysis and verified by immunohistochemistrystratifin (SFN), YWHAZ, and hnRNPKachieved a sensitivity of 0.83, 0.91, specificity of 0.74, 0.95, and predictive value of 0.87 and 0.96, respectively, in discriminating dysplasias from normal tissues, thereby confirming their utility as potential OPL biomarkers.
  • In conclusion, our work on determining the OPL proteome unraveled novel networks linking inflammation and development of epithelial dysplasia and their key regulatory proteins may serve as novel chemopreventive/therapeutic targets for early intervention.
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Squamous Cell / diagnosis. Humans. Inflammation. Models, Biological. Mouth Neoplasms / diagnosis. Proteome. ROC Curve. Reverse Transcriptase Polymerase Chain Reaction

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19072117.001).
  • [ISSN] 1535-3893
  • [Journal-full-title] Journal of proteome research
  • [ISO-abbreviation] J. Proteome Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Biomarkers, Tumor; 0 / Proteome
  •  go-up   go-down


46. Kujan O, Oliver RJ, Khattab A, Roberts SA, Thakker N, Sloan P: Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation. Oral Oncol; 2006 Nov;42(10):987-93
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation.
  • The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the WHO classification 2005.
  • Ninety-six consecutive oral epithelial dysplasia biopsies with known clinical outcomes were retrieved from the Oral Pathology archives.
  • Interestingly, all pathologists showed satisfactory agreement on the distinction of mild dysplasia from severe dysplasia and from carcinoma in situ using the new WHO classification.
  • However, assessment of moderate dysplasia remains problematic.
  • The sensitivity and specificity of the new binary grading system for predicting malignant transformation in oral epithelial dysplasia were 85% and 80%, respectively and the accuracy was 82%.
  • The new binary grading system complemented the WHO Classification 2005 and may have merit in helping clinicians to make critical clinical decisions particularly for the cases of moderate dysplasia.
  • Histological grading of dysplasia using established criteria is a reproducible prognosticator in oral epithelial dysplasia.
  • Furthermore, the present study showed that more consensus scoring on either the degree of dysplasia, assessment of risk or the presence of each morphological characteristic by a panel should be encouraged.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16731030.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


47. Volchenko NN, Medovyĭ VS, Klimova NV, Slavnova EN, Savostikova MV: [Cytomorphometric diagnosis of dysplasias during dyshormonal and hyperplastic processes in the mammary gland]. Klin Lab Diagn; 2006 May;(5):52-4
MedlinePlus Health Information. consumer health - Breast Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Cytomorphometric diagnosis of dysplasias during dyshormonal and hyperplastic processes in the mammary gland].
  • A hundred and twenty-nine cytograms of benign tumors of the breast with different degrees of its dysplasia were morphometrically analyzed, by using a "MECOS-Ts" set for digital microscopy.
  • The informative differentially diagnostic morphometric signs of nuclei were identified in mild, moderate, and severe epithelial dysplasias of the breast.
  • The derived quantitative decision rules may reduce the error of a differential diagnosis of severe dysplasia by 2-3.5 times, as compared with a visual microscopy-based diagnosis.
  • [MeSH-major] Breast Neoplasms / diagnosis. Fibrocystic Breast Disease / diagnosis. Precancerous Conditions / diagnosis

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16827243.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Hormones
  •  go-up   go-down


48. Al-Osman A, Perry JB, Birek C: Extensive papillomatosis of the palate exhibiting epithelial dysplasia and HPV 16 gene expression in a renal transplant recipient. J Can Dent Assoc; 2006 May;72(4):331-4
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Extensive papillomatosis of the palate exhibiting epithelial dysplasia and HPV 16 gene expression in a renal transplant recipient.
  • The condition resembled inflammatory papillary hyperplasia; it exhibited severe epithelial dysplasia and concurred with generalized gingival hyperplasia.
  • [MeSH-major] Focal Epithelial Hyperplasia / pathology. Immunosuppression / adverse effects. Palatal Neoplasms / virology. Papilloma / virology. Papillomavirus Infections / etiology

  • Genetic Alliance. consumer health - Renal dysplasia.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16684477.001).
  • [ISSN] 1488-2159
  • [Journal-full-title] Journal (Canadian Dental Association)
  • [ISO-abbreviation] J Can Dent Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
  • [Chemical-registry-number] 0 / RNA, Viral
  •  go-up   go-down


49. Väänänen A, Ylipalosaari M, Parikka M, Kainulainen T, Rehn M, Heljasvaara R, Tjäderhane L, Salo T: Collagen XVIII modulation is altered during progression of oral dysplasia and carcinoma. J Oral Pathol Med; 2007 Jan;36(1):35-42
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Collagen XVIII modulation is altered during progression of oral dysplasia and carcinoma.
  • METHODS: Using immunohistochemistry and in situ hybridization, we studied the expression and localization of collagen XVIII in different stages of normal oral wound healing, epithelial dysplasia and squamous cell carcinoma (SCC).
  • RESULTS: In mild epithelial dysplasias collagen XVIII appeared as a continuous signal in the BM, whereas in severe epithelial dysplasias and in the invasive areas of oral SCCs collagen XVIII was absent.
  • In situ hybridization showed that collagen XVIII mRNA expression did not decrease in severe dysplasia or oral carcinoma samples when compared with the mild dysplasias.
  • CONCLUSIONS: The results indicate that the absence of collagen XVIII protein in severe oral dysplasias is related to the processing of the protein rather than to changes in mRNA expression.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Collagen Type XVIII / analysis. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Angiogenesis Inhibitors / analysis. Basement Membrane / pathology. Cell Line, Tumor. Cell Transformation, Neoplastic / pathology. Endostatins / analysis. Humans. Immunohistochemistry. In Situ Hybridization. Matrix Metalloproteinase 9 / analysis. Neoplasm Invasiveness. Protein Modification, Translational. RNA, Messenger / analysis. Wound Healing / physiology

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17181740.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Collagen Type XVIII; 0 / Endostatins; 0 / RNA, Messenger; EC 3.4.24.35 / Matrix Metalloproteinase 9
  •  go-up   go-down


50. Shigeishi H, Higashikawa K, Hiraoka M, Fujimoto S, Mitani Y, Ohta K, Takechi M, Kamata N: Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas. Oncol Rep; 2008 Jun;19(6):1557-64
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We examined the expression of epiregulin and amphiregulin mRNA in 39 oral SCCs, 2 epithelial dysplasias and 7 normal gingivae by real-time RT-PCR.
  • The mean expression level of epiregulin mRNA was higher in oral SCCs (0.29+/-0.50) than normal gingivae (0.01+/-0.007) and epithelial dysplasias (0.01+/-0.001).
  • The mean expression level of amphiregulin mRNA was higher in oral SCCs (0.18+/-0.24) than normal gingivae (0.002+/-0.003) and epithelial dysplasias (0.01+/-0.001).
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Epidermal Growth Factor / genetics. Gene Expression Regulation, Neoplastic / physiology. Mouth Neoplasms / genetics. Receptor, Epidermal Growth Factor / metabolism

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18497965.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / AREG protein, human; 0 / Amphiregulin; 0 / EGF Family of Proteins; 0 / EREG protein, human; 0 / Epiregulin; 0 / Glycoproteins; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ligands; 0 / RNA, Messenger; 62229-50-9 / Epidermal Growth Factor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
  •  go-up   go-down


51. Li JN, Feng CJ, Lu YJ, Li HJ, Tu Z, Liao GQ, Liang C: mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue. BMC Cancer; 2008;8:395
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue.
  • Overexpression of the DNA replication-initiation proteins has been associated with dysplasia and malignancy.
  • RESULTS: We found that the expression levels are significantly higher in malignant SCC than mild precancerous epithelial dysplasia, and the expression levels in general increase with increasing grade of precancerous lesions from mild, moderate to severe epithelial dysplasia.
  • CDC6 and CDC45 expression is dependent of the dysplasia grade and lymph node status.
  • CDT1 expression is higher in severe dysplasia than in mild and moderate dysplasia.
  • MCM2 expression is dependent of the dysplasia grade, lymph node status and clinical stage.
  • A simple linear regression analysis revealed a linear increase in the mRNA levels of the four genes from the mild to severe dysplasia and SCC.
  • The nonparametric receiver operating characteristic analysis suggested that MCM2 and CDC45 had a higher accuracy than CDC6 and CDT1 for distinguishing dysplasia from tongue SCC.
  • CONCLUSION: These proteins can be used as biomarkers to distinguish precancerous dysplasia from SCC and are useful for early detection and diagnosis of SCC as an adjunct to clinicopathological parameters.
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Cell Cycle Proteins / genetics. Nuclear Proteins / genetics. Tongue Neoplasms / genetics
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / genetics. DNA Replication. Epithelial Cells / metabolism. Epithelial Cells / pathology. Female. Gene Expression Regulation, Neoplastic. Humans. Male. Middle Aged. Minichromosome Maintenance Complex Component 2. RNA, Messenger / genetics. Young Adult

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • COS Scholar Universe. author profiles.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Cancer Res. 2007 Nov 15;67(22):10899-909 [18006835.001]
  • [Cites] FEBS J. 2007 Jul;274(14):3669-84 [17608804.001]
  • [Cites] J Cell Sci. 2001 Jun;114(Pt 11):2027-41 [11493639.001]
  • [Cites] Methods. 2001 Dec;25(4):409-18 [11846610.001]
  • [Cites] Oncogene. 2002 Feb 14;21(8):1150-8 [11850834.001]
  • [Cites] Pathobiology. 2001;69(3):150-8 [11872961.001]
  • [Cites] Annu Rev Biochem. 2002;71:333-74 [12045100.001]
  • [Cites] Cell. 2002 Jun 28;109(7):849-60 [12110182.001]
  • [Cites] CA Cancer J Clin. 2002 Jul-Aug;52(4):195-215 [12139232.001]
  • [Cites] Genes Dev. 2002 Oct 15;16(20):2639-49 [12381663.001]
  • [Cites] Curr Opin Plant Biol. 2002 Dec;5(6):480-6 [12393009.001]
  • [Cites] Eur J Biochem. 2003 Mar;270(6):1089-101 [12631269.001]
  • [Cites] Cancer Cell. 2003 Apr;3(4):311-6 [12726857.001]
  • [Cites] Cancer Res. 2003 Nov 1;63(21):7356-64 [14612534.001]
  • [Cites] Oncogene. 2004 May 6;23(21):3802-12 [14990995.001]
  • [Cites] Exp Mol Med. 2004 Apr 30;36(2):165-71 [15150445.001]
  • [Cites] Blood. 1997 Feb 1;89(3):965-74 [9028328.001]
  • [Cites] Lab Invest. 1998 Jan;78(1):73-8 [9461123.001]
  • [Cites] Mol Cell Biol. 1998 Nov;18(11):6679-97 [9774682.001]
  • [Cites] J Oral Pathol Med. 1998 Oct;27(9):434-40 [9790097.001]
  • [Cites] J Clin Pathol. 2005 May;58(5):525-34 [15858126.001]
  • [Cites] Head Neck. 2000 Jul;22(4):347-54 [10862017.001]
  • (PMID = 19116018.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDC45 protein, human; 0 / CDC6 protein, human; 0 / CDT1 protein, human; 0 / Cell Cycle Proteins; 0 / Nuclear Proteins; 0 / RNA, Messenger; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
  • [Other-IDs] NLM/ PMC2648984
  •  go-up   go-down


52. Park DY, Srivastava A, Kim GH, Mino-Kenudson M, Deshpande V, Zukerberg LR, Song GA, Lauwers GY: CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance. Mod Pathol; 2010 Jan;23(1):54-61
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance.
  • CDX2 is an intestinal transcription factor responsible for regulating the proliferation and differentiation of intestinal epithelial cells.
  • The aims of this study were to analyze CDX2 expression in a series of well-characterized cases of gastric epithelial dysplasia, based on the morphologic and mucin phenotypes, and also to analyze CDX2 expression along the metaplasia-dysplasia-carcinoma sequence.
  • CDX2 expression was evaluated in 69 cases of gastric epithelial dysplasia, 88 cases of intestinal-type early gastric cancers, and 56 cases of advanced gastric cancers.
  • Increased CDX2 expression was more frequently associated with adenomatous-type gastric epithelial dysplasia (27/31, 87%) compared with foveolar (7/15, 47%) or hybrid (10/23, 44%) types of gastric epithelial dysplasia (P=0.001).
  • CDX2 expression correlated with an increase in CD10 expression (P=0.005), and a decrease in MUC5AC expression (P=0.001) in gastric epithelial dysplasia.
  • CDX2 expression was also gradually decreased from gastric epithelial dysplasia, to early and advanced gastric cancers (present in 64, 40 and 27% of the cases, respectively).
  • Our results indicate that CDX2 expression is associated with specific morphological and mucin phenotypes of gastric epithelial dysplasias, and decreases progressively with the advancing stage of gastric cancers, suggesting a possible tumor suppressor role for CDX2.
  • [MeSH-major] Adenocarcinoma / metabolism. Adenocarcinoma / pathology. Homeodomain Proteins / biosynthesis. Stomach Neoplasms / metabolism. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / analysis. Female. Humans. Immunohistochemistry. Intestinal Mucosa / pathology. Male. Middle Aged. Mucin 5AC / biosynthesis. Neoplasm Staging. Neprilysin / biosynthesis. Phenotype. Precancerous Conditions / metabolism. Precancerous Conditions / pathology

  • MedlinePlus Health Information. consumer health - Stomach Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19820687.001).
  • [ISSN] 1530-0285
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / CDX2 protein, human; 0 / Homeodomain Proteins; 0 / MUC5AC protein, human; 0 / Mucin 5AC; EC 3.4.24.11 / Neprilysin
  •  go-up   go-down


53. Yu CH, Chen HM, Hung HY, Cheng SJ, Tsai T, Chiang CP: Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion. Oral Oncol; 2008 Jun;44(6):595-600

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion.
  • OVH lesions with an clinical appearance of a mass, with the greatest diameter <1.5 cm, with the pink color, with epithelial dysplasia, or with the surface keratin layer < or =40 microm needed significantly less mean treatment numbers of PDT to achieve a CR than OVH lesions with an outer appearance of a plaque or a combination type of peripheral plaque and central mass (p=0.000), with the greatest diameter > or =1.5 cm (p=0.011), with the white color (p=0.000), without epithelial dysplasia (p=0.043), or with the surface keratin layer > 40 microm(p=0.003), respectively.
  • The PDT treatment outcome for OVH depends on the outer appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18203648.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
  •  go-up   go-down


54. Fong Y, Chou SJ, Hung KF, Wu HT, Kao SY: An investigation of the differential expression of Her2/neu gene expression in normal oral mucosa, epithelial dysplasia, and oral squamous cell carcinoma in Taiwan. J Chin Med Assoc; 2008 Mar;71(3):123-7
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] An investigation of the differential expression of Her2/neu gene expression in normal oral mucosa, epithelial dysplasia, and oral squamous cell carcinoma in Taiwan.
  • METHODS: Immunohistochemistry (IHC) was used to detect Her2/neu expression in normal oral mucosa (NOM) (n = 20), oral precancerous lesions of epithelial dysplasia (ED) (n = 20), and oral squamous cell carcinoma (OSCC) (n = 30).
  • [MeSH-major] Carcinoma, Squamous Cell / chemistry. Mouth Mucosa / chemistry. Mouth Neoplasms / chemistry. Precancerous Conditions / chemistry. Receptor, ErbB-2 / analysis. Receptor, ErbB-2 / genetics


55. Cury PR, Furuse C, de Araújo NS, de Araújo VC: Signal transducer and activator of transcription-3 expression and activation is dysregulated in actinic cheilitis. J Cutan Pathol; 2007 Aug;34(8):606-11
Genetic Alliance. consumer health - Actinic Cheilitis.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: The present study evaluates the signal transducer and activator of transcription-3 (STAT-3) expression and activation in actinic cheilitis (AC) and the relationship of this protein with the degree of epithelial dysplasia.
  • AC lesions were graded as mild, moderate and severe dysplasias.
  • In AC, STAT-3 was expressed in the cell cytoplasm of the epithelial layers, except in the superficial layer.
  • Nuclear expression of STAT-3 in occasional basal and parabasal cells was seen in moderate and severe dysplasias.
  • However, in moderate and severe dysplasias, some epithelial cells exhibited loss of STAT-3P expression.
  • CONCLUSION: In AC, STAT-3 expression depends on the degree of dysplasia, and STAT-3 activation is dysregulated compared with normal tissue.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17640230.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / STAT3 Transcription Factor; 0 / STAT3 protein, human
  •  go-up   go-down


56. Xavier FC, Takiya CM, Reis SR, Ramalho LM: p63 Immunoexpression in lip carcinogenesis. J Mol Histol; 2009 Apr;40(2):131-7
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Actinic cheilitis (AC) is a potentially malignant disorder, which can present degrees of epithelial dysplasia, and may even evolve into lip squamous cell carcinoma (LSCC).
  • Since p63 is a protein homologous to p53, which can be associated with tumorigenesis in epithelial tissues, this study aims to evaluate it in AC and LSCC, in the hopes to estimate the biological behavior of these lesions.
  • There was no statistically significant difference between immunostained cells and degree of epithelial dysplasias, nor between the LSCC grading malignancy.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Cheilitis / metabolism. Gene Expression Regulation, Neoplastic. Lip Neoplasms / metabolism. Membrane Proteins / metabolism

  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19526317.001).
  • [ISSN] 1567-2387
  • [Journal-full-title] Journal of molecular histology
  • [ISO-abbreviation] J. Mol. Histol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / CKAP4 protein, human; 0 / Membrane Proteins
  •  go-up   go-down


57. Chung WC, Jung SH, Lee KM, Paik CN, Kawk JW, Jung JH, Lee MK, Lee YK: The detection of Helicobacter pylori cag pathogenicity islands (PAIs) and expression of matrix metalloproteinase-7 (MMP-7) in gastric epithelial dysplasia and intramucosal cancer. Gastric Cancer; 2010 Aug;13(3):162-9
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The detection of Helicobacter pylori cag pathogenicity islands (PAIs) and expression of matrix metalloproteinase-7 (MMP-7) in gastric epithelial dysplasia and intramucosal cancer.
  • Matrix metalloproteinase-7(MMP-7) is upregulated in the epithelial cells of gastric cancer.
  • In this study, we aimed to identify virulent H. pylori strains and the expression of MMP-7 in samples of gastric epithelial dysplasia and intramucosal cancer.
  • METHODS: One hundred and twelve tissues excised by endoscopic mucosal resection, 76 specimens with gastric epithelial dysplasia and 36 with intramucosal cancer, were examined.
  • All tissue samples were paired with surrounding normal epithelial tissue samples.
  • We performed polymerase chain reaction for cagA and cagL in neoplasia and paired normal specimens, and assessed the matrix metalloproteinase (MMP)-7 expression by immunohistochemical staining.
  • RESULTS: There was a significant difference in the frequencies of cagA or cagL between specimens with gastric dysplasia and those with intramucosal cancer.
  • [MeSH-major] Genomic Islands. Helicobacter Infections / enzymology. Helicobacter pylori / pathogenicity. Matrix Metalloproteinase 7 / biosynthesis. Stomach Neoplasms / enzymology

  • MedlinePlus Health Information. consumer health - Helicobacter Pylori Infections.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20820985.001).
  • [ISSN] 1436-3305
  • [Journal-full-title] Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
  • [ISO-abbreviation] Gastric Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antigens, Bacterial; 0 / Bacterial Proteins; 0 / cagA protein, Helicobacter pylori; EC 3.4.24.23 / Matrix Metalloproteinase 7
  •  go-up   go-down


58. Meyer P, Messerli J: [Inflammation of the conjunctiva]. Ther Umsch; 2009 Mar;66(3):153-61
MedlinePlus Health Information. consumer health - Pinkeye.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Neoplastic processes such as low grade epithelial dysplasias and lymphomas may mascarade conjunctivitis.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19266461.001).
  • [ISSN] 0040-5930
  • [Journal-full-title] Therapeutische Umschau. Revue thérapeutique
  • [ISO-abbreviation] Ther Umsch
  • [Language] ger
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 0 / Adrenal Cortex Hormones; 0 / Anti-Bacterial Agents; 0 / Anti-Inflammatory Agents, Non-Steroidal; 0 / Histamine Antagonists; 0 / Ophthalmic Solutions
  • [Number-of-references] 0
  •  go-up   go-down


59. Tilakaratne WM, Kobayashi T, Ida-Yonemochi H, Swelam W, Yamazaki M, Mikami T, Alvarado CG, Shahidul AM, Maruyama S, Cheng J, Saku T: Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers. J Oral Pathol Med; 2009 Apr;38(4):348-55
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers.
  • BACKGROUND: As one of the valuable tools for differential diagnoses of oral epithelial dysplasia, carcinoma in situ (CIS) and squamous cell carcinoma (SCC), we have proposed the immunohistochemistry for perlecan, a heparan sulfate proteoglycan (HSPG).
  • METHODS: Twenty cases each of moderate dysplasia, CIS, SCC, and normal/hyperplastic/mild dysplastic epithelia of the tongue and buccal mucosa were immunohistochemically examined for MMP-1, -2 and -7 in reference to their perlecan immunolocalization.
  • The most striking finding was strong expression of MMP-7 in epithelial dysplasia with a two-phase appearance: a clear demarcation of MMP-7-immunopositive (+) lower dysplastic/basaloid cells from non-positive upper keratinized cells.
  • MMP-7+ cells were spread over the whole epithelial layer of CIS.
  • CONCLUSION: These results suggest that the enhanced metabolism of perlecan associated with MMP-7 plays an important role in the cell proliferation of oral epithelia in their malignant transformation process, and that MMP-7 immunohistochemistry may be a valuable aid for identification of the cell proliferation center in oral CIS and dysplasia.
  • [MeSH-major] Carcinoma in Situ / metabolism. Carcinoma, Squamous Cell / metabolism. Cell Transformation, Neoplastic / metabolism. Heparan Sulfate Proteoglycans / metabolism. Matrix Metalloproteinase 7 / biosynthesis. Precancerous Conditions / metabolism. Tongue Neoplasms / metabolism
  • [MeSH-minor] Cell Proliferation. Diagnosis, Differential. Epithelial Cells / metabolism. Epithelial Cells / pathology. Humans. Immunohistochemistry. Matrix Metalloproteinase 1 / biosynthesis. Matrix Metalloproteinase 2 / biosynthesis

  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19239574.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Heparan Sulfate Proteoglycans; 143972-95-6 / perlecan; EC 3.4.24.23 / Matrix Metalloproteinase 7; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.7 / Matrix Metalloproteinase 1
  •  go-up   go-down


60. Kurtovic M, Mehmedbasic S, Drljevic K, Drljevic I: Frequency of HPV infection in pre-malignant lesions of cervix at the public institution "Institute for Health Protection of Women and Maternity" of Sarajevo Canton. Med Arh; 2009;63(1):24-7
MedlinePlus Health Information. consumer health - Cervical Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONCLUSION: HPV infection is most common in women 20-30 years of age and is present in all types of epithelial dysplasias.
  • [MeSH-major] Papillomavirus Infections / complications. Precancerous Conditions / virology. Uterine Cervical Neoplasms / virology
  • [MeSH-minor] Adult. Cervical Intraepithelial Neoplasia / virology. Female. Humans. Middle Aged. Risk Factors. Young Adult

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19419122.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
  •  go-up   go-down


61. Shigeishi H, Higashikawa K, Ono S, Mizuta K, Ninomiya Y, Yoneda S, Taki M, Kamata N: Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncol Rep; 2006 Nov;16(5):1071-5
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We examined the expression of Centromere protein H (CENP-H) mRNA in 38 oral squamous cell carcinomas (SCCs), 2 epithelial dysplasias and 5 normal gingivae using the real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR).
  • The mean expression level of CENP-H mRNA was higher in oral SCCs (0.11+/-0.08) than epithelial dysplasias (0.03+/-0.01) and normal gingivae (0.027+/-0.01).
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / pathology. Chromosomal Proteins, Non-Histone / genetics. Mouth Neoplasms / genetics. Mouth Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17016595.001).
  • [ISSN] 1021-335X
  • [Journal-full-title] Oncology reports
  • [ISO-abbreviation] Oncol. Rep.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CENPH protein, human; 0 / Chromosomal Proteins, Non-Histone; 0 / Ki-67 Antigen; 0 / RNA, Messenger
  •  go-up   go-down


62. Srivastava A, Lauwers GY: Gastric epithelial dysplasia: the Western perspective. Dig Liver Dis; 2008 Aug;40(8):641-9
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Gastric epithelial dysplasia: the Western perspective.
  • The aggressive surveillance and definite therapy for low and high-grade dysplasia, which can be achieved endoscopic means, remains the cornerstone of clinical management.
  • Although the precursor status of dysplasia is not contested, its classification is controversial and fraught with marked inter-observer variations.
  • Most cases of gastric dysplasia have an "intestinal" phenotype referred to as adenomatous dysplasia.
  • Hyperplastic (type II dysplasia) is another less common variant.
  • The progression of dysplasia to carcinoma is paralleled by a stepwise accumulation of multiple, but yet uncertain, genetic abnormalities.
  • Given the low rate of transformation of low-grade dysplasia, annual endoscopic surveillance with re-biopsy is advocated.
  • A diagnosis of indefinite for dysplasia should also prompt endoscopic surveillance.
  • A diagnosis of high-grade dysplasia is more ominous, since it progress to cancer in most cases.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Gastric Mucosa / pathology. Precancerous Conditions / pathology. Stomach Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18424243.001).
  • [ISSN] 1878-3562
  • [Journal-full-title] Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • [ISO-abbreviation] Dig Liver Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  •  go-up   go-down


63. Fontes A, de Sousa SM, dos Santos E, Martins MT: The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis. J Cutan Pathol; 2009 Nov;36(11):1151-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis.
  • METHODS: Sections from 36 cases diagnosed as AC (18 cases with mild epithelial dysplasia, 11 with moderate and 7 with severe), 18 cases diagnosed as lip SCC and 7 specimens containing normal lip vermillion epithelium were submitted for immunohistochemical analysis to detect maspin.
  • RESULTS: All AC cases with mild and two cases with moderate dysplasia were scored 3.
  • The remaining nine cases with moderate dysplasia were identified as score 2, whereas all cases with severe dysplasia were scored 1.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / metabolism. Lip Neoplasms / metabolism. Precancerous Conditions / metabolism. Serpins / biosynthesis

  • Genetic Alliance. consumer health - Actinic Cheilitis.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19222699.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / SERPIN-B5; 0 / Serpins
  •  go-up   go-down


64. Tuganova TN, Bolgova LS, Alekseenko OI, Ligirda NF: [Reasons for cytohistological differences in the determination of the degree of epithelial dysplasia of the cervix uteri]. Klin Lab Diagn; 2009 Feb;(2):46-50

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Reasons for cytohistological differences in the determination of the degree of epithelial dysplasia of the cervix uteri].
  • Retrospective cytohistological comparison of the results of two morphological methods for diagnosing epithelial dysplastic changes in the cervix uteri made it possible to reveal and analyze a number of objective and subjective reasons for misinterpretation of cytological specimens.
  • [MeSH-major] Diagnostic Errors. Uterine Cervical Dysplasia / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19334479.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  •  go-up   go-down


65. Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH: Somatic LKB1 mutations promote cervical cancer progression. PLoS One; 2009;4(4):e5137
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Yet, infection with HPV is not sufficient to cause cervical cancer, because most infected women develop transient epithelial dysplasias that spontaneously regress.
  • LKB1 is thus a major cervical tumor suppressor, demonstrating that acquired genetic alterations drive progression of HPV-induced dysplasias to invasive, lethal cancers.

  • Genetic Alliance. consumer health - Cervical cancer.
  • Genetics Home Reference. consumer health - STK11 gene.
  • MedlinePlus Health Information. consumer health - Cervical Cancer.
  • COS Scholar Universe. author profiles.
  • International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Am J Obstet Gynecol. 1997 Jun;176(6):S227-8 [9215212.001]
  • [Cites] EMBO J. 1984 May;3(5):1151-7 [6329740.001]
  • [Cites] Semin Surg Oncol. 1999 Apr-May;16(3):203-11 [10225296.001]
  • [Cites] Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9248-51 [10430928.001]
  • [Cites] Biochem Biophys Res Commun. 1999 Aug 11;261(3):750-5 [10441497.001]
  • [Cites] J Clin Pathol. 2005 Mar;58(3):313-6 [15735167.001]
  • [Cites] Clin Cancer Res. 2006 May 15;12(10):3209-15 [16707622.001]
  • [Cites] Annu Rev Biochem. 2006;75:137-63 [16756488.001]
  • [Cites] Nature. 2007 Aug 16;448(7155):807-10 [17676035.001]
  • [Cites] Oncogene. 2007 Aug 30;26(40):5911-8 [17384680.001]
  • [Cites] Gynecol Oncol. 2007 Nov;107(2 Suppl 1):S2-5 [17938014.001]
  • [Cites] Obstet Gynecol. 2008 Jan;111(1):167-77 [18165406.001]
  • [Cites] Cancer Res. 2008 Jan 1;68(1):55-63 [18172296.001]
  • [Cites] Cancer Res. 2008 Feb 1;68(3):759-66 [18245476.001]
  • [Cites] Cancer Res. 2008 Apr 1;68(7):2223-32 [18381428.001]
  • [Cites] Cancer Res. 2008 Oct 15;68(20):8249-59 [18922896.001]
  • [Cites] Oncogene. 2008 Nov 24;27(55):6908-19 [19029933.001]
  • [Cites] Am J Pathol. 2000 Jan;156(1):339-45 [10623683.001]
  • [Cites] Oncogene. 2000 Jan 6;19(1):164-8 [10644993.001]
  • [Cites] Cancer Res. 2000 Feb 1;60(3):546-8 [10676634.001]
  • [Cites] Nat Rev Cancer. 2002 Apr;2(4):315-9 [12001993.001]
  • [Cites] Histopathology. 2002 Sep;41(3):185-207 [12207781.001]
  • [Cites] Nature. 2002 Sep 12;419(6903):162-7 [12226664.001]
  • [Cites] Hum Mutat. 2003 Feb;21(2):172 [12552571.001]
  • [Cites] Cancer Cell. 2004 Jun;5(6):533-8 [15193256.001]
  • [Cites] Obstet Gynecol. 1971 Dec;38(6):945-9 [4942173.001]
  • [Cites] Science. 1976 Jan 30;191(4225):392-4 [1246620.001]
  • [Cites] Cancer Res. 1976 Feb;36(2 pt 2):794 [175942.001]
  • [Cites] Am J Pathol. 1999 Mar;154(3):677-81 [10079245.001]
  • (PMID = 19340305.001).
  • [ISSN] 1932-6203
  • [Journal-full-title] PloS one
  • [ISO-abbreviation] PLoS ONE
  • [Language] ENG
  • [Grant] United States / NCRR NIH HHS / RR / K26 RR024196; United States / NCRR NIH HHS / RR / RR024196-02; United States / NCRR NIH HHS / RR / K26 RR024196-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
  • [Other-IDs] NLM/ PMC2660434
  •  go-up   go-down


66. Joo M, Kim H, Kim MK, Yu HJ, Kim JP: Expression of Ep-CAM in intestinal metaplasia, gastric epithelial dysplasia and gastric adenocarcinoma. J Gastroenterol Hepatol; 2005 Jul;20(7):1039-45
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of Ep-CAM in intestinal metaplasia, gastric epithelial dysplasia and gastric adenocarcinoma.
  • BACKGROUND: The epithelial cell adhesion molecule (Ep-CAM) is widely associated with human carcinomas.
  • METHOD: We examined the expression of Ep-CAM in 99 cases of gastric adenocarcinoma and associated uninvolved gastric mucosa, 39 cases of gastric biopsy specimens with chronic gastritis (CG) with or without intestinal metaplasia (IM) (25 cases) and gastric epithelial dysplasia (GED) (14 cases) by immunohistochemical staining.
  • [MeSH-major] Adenocarcinoma / metabolism. Antigens, Neoplasm / biosynthesis. Cell Adhesion Molecules / biosynthesis. Gastric Mucosa / metabolism. Intestines / pathology. Stomach Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Immunohistochemistry. In Vitro Techniques. Male. Metaplasia / metabolism. Metaplasia / pathology. Middle Aged. Neoplasm Staging

  • MedlinePlus Health Information. consumer health - Stomach Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15955212.001).
  • [ISSN] 0815-9319
  • [Journal-full-title] Journal of gastroenterology and hepatology
  • [ISO-abbreviation] J. Gastroenterol. Hepatol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / Biomarkers, Tumor; 0 / Cell Adhesion Molecules; 0 / EPCAM protein, human
  •  go-up   go-down


67. Jaber MA: Oral epithelial dysplasia in non-users of tobacco and alcohol: an analysis of clinicopathologic characteristics and treatment outcome. J Oral Sci; 2010 Mar;52(1):13-21
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral epithelial dysplasia in non-users of tobacco and alcohol: an analysis of clinicopathologic characteristics and treatment outcome.
  • Oral epithelial dysplasia (OED) is a histopathological diagnosis that is associated with an increased risk of oral cancer.
  • An erythro-leukoplakic-type lesion with mild dysplasia was the common presenting feature.
  • [MeSH-major] Alcohol Drinking. Carcinoma, Squamous Cell / pathology. Epithelial Cells / pathology. Leukoplakia, Oral / pathology. Mouth Mucosa / pathology. Mouth Neoplasms / pathology. Smoking

  • MedlinePlus Health Information. consumer health - Alcohol.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • MedlinePlus Health Information. consumer health - Smoking.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20339228.001).
  • [ISSN] 1880-4926
  • [Journal-full-title] Journal of oral science
  • [ISO-abbreviation] J Oral Sci
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  •  go-up   go-down


68. Thirthagiri E, Robinson CM, Huntley S, Davies M, Yap LF, Prime SS, Paterson IC: Spindle assembly checkpoint and centrosome abnormalities in oral cancer. Cancer Lett; 2007 Dec 18;258(2):276-85
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Centrosomal abnormalities were then examined in tissue samples of oral epithelial dysplasias and carcinomas.
  • The percentage of cells containing centrosome abnormalities was significantly higher in the carcinomas than in the dysplasias (p<0.02) and in the poorly differentiated SCCs relative to their moderately differentiated (p<0.04) and well-differentiated (p<0.01) counterparts.
  • The presence of centrosome abnormalities in oral dysplasias raises the possibility that such defects might contribute to malignant progression.
  • [MeSH-minor] Aneuploidy. Blotting, Western. Caco-2 Cells. Calcium-Binding Proteins / metabolism. Cdc20 Proteins. Cell Cycle Proteins / metabolism. Cell Line, Tumor. Flow Cytometry. HCT116 Cells. Humans. Mad2 Proteins. Mitotic Index. Mouth Mucosa / metabolism. Mouth Mucosa / pathology. Mouth Neoplasms / genetics. Mouth Neoplasms / metabolism. Mouth Neoplasms / pathology. Repressor Proteins / metabolism

  • Genetic Alliance. consumer health - Oral cancer.
  • COS Scholar Universe. author profiles.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17959302.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Calcium-Binding Proteins; 0 / Cdc20 Proteins; 0 / Cell Cycle Proteins; 0 / MAD2L1 protein, human; 0 / Mad2 Proteins; 0 / Repressor Proteins; 156288-95-8 / CDC20 protein, human
  •  go-up   go-down


69. Silva SD, Cunha IW, Rangel AL, Jorge J, Zecchin KG, Agostini M, Kowalski LP, Coletta RD, Graner E: Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. Virchows Arch; 2008 Jul;453(1):57-67
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • FAS expression was higher in hyperkeratosis, dysplasias, and OSCC than in normal epithelium.
  • Ki-67 index is higher in epithelial dysplasias and OSCC than in morphologically normal oral epithelium.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Fatty Acid Synthases / metabolism. Head and Neck Neoplasms / metabolism. Keratinocytes / metabolism. Mouth / metabolism. Mouth Neoplasms / metabolism. Receptor, ErbB-2 / metabolism

  • MedlinePlus Health Information. consumer health - Head and Neck Cancer.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18528705.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Germany
  • [Chemical-registry-number] EC 2.3.1.85 / Fatty Acid Synthases; EC 2.7.10.1 / ERBB2 protein, human; EC 2.7.10.1 / Receptor, ErbB-2
  •  go-up   go-down


70. Chen YK, Huse SS, Lin LM: Inhibitory effect of inducible nitric oxide synthase inhibitors on DMBA-induced hamster buccal-pouch squamous-cell carcinogenesis. Nitric Oxide; 2005 Dec;13(4):232-9
Hazardous Substances Data Bank. 7,12-DIMETHYLBENZ(A)ANTHRACENE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • We investigated the effects of two NOS inhibitors (AG and l-NAME) on DMBA-induced hamster buccal-pouch carcinogenesis.
  • Post-mortem analysis revealed that both inhibitors can suppress the development of epithelial dysplasias and squamous-cell carcinomas.
  • An associated increase in the numbers of epithelial hyperplasias was paralleled by a decrease in iNOS protein expression.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16125987.001).
  • [ISSN] 1089-8603
  • [Journal-full-title] Nitric oxide : biology and chemistry
  • [ISO-abbreviation] Nitric Oxide
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Enzyme Inhibitors; 0 / Guanidines; 57-97-6 / 9,10-Dimethyl-1,2-benzanthracene; EC 1.14.13.39 / Nitric Oxide Synthase Type II; SCQ4EZQ113 / pimagedine; V55S2QJN2X / NG-Nitroarginine Methyl Ester
  •  go-up   go-down


71. Villarroel Dorrego M, Speight PM, Barrett AW: The immunohistology of CD40 in human oral epithelium in health and disease. J Oral Pathol Med; 2006 May;35(5):268-73
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Expression was lost in nine of 33 (27%) epithelial dysplasias, seven of which were severe.
  • Expression is lost in approximately one-third of oral epithelial dysplasias and OSCC.
  • [MeSH-major] Antigens, CD40 / immunology. Carcinoma, Squamous Cell / immunology. Keratinocytes / immunology. Mouth Mucosa / immunology. Mouth Neoplasms / immunology

  • Genetic Alliance. consumer health - Oral Health.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16630289.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD40
  •  go-up   go-down


72. Kujan O, Khattab A, Oliver RJ, Roberts SA, Thakker N, Sloan P: Why oral histopathology suffers inter-observer variability on grading oral epithelial dysplasia: an attempt to understand the sources of variation. Oral Oncol; 2007 Mar;43(3):224-31
COS Scholar Universe. author profiles.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Why oral histopathology suffers inter-observer variability on grading oral epithelial dysplasia: an attempt to understand the sources of variation.
  • The present study attempted to assess the reasons behind the inter-observer variation in grading oral epithelial dysplasia (OED).
  • Despite these observations, comparing these data with that from our previous paper on the same slides showed that the inter-observer agreement on the degree of dysplasia either by using the new binary system of "low-risk" or "high-risk" or by using the 2005 WHO classification turned out to be better than the agreement on the individual characteristics of architecture and cytology changes.
  • In conclusion, grading dysplasia is not an exact science and pathologists are doing their best to reach optimal results.
  • [MeSH-major] Carcinoma in Situ / pathology. Mouth Neoplasms / pathology

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16931119.001).
  • [ISSN] 1368-8375
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


73. García-Flórez LJ: [High-grade gastric epithelial dysplasia. Diagnostic and therapeutic controversies]. Cir Esp; 2007 Apr;81(4):222-3
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [High-grade gastric epithelial dysplasia. Diagnostic and therapeutic controversies].
  • [Transliterated title] Displasia epitelial gástrica de alto grado. Controversias diagnósticas y terapéuticas.
  • Gastric epithelial dysplasia is a premalignant lesion.
  • [MeSH-major] Gastric Mucosa / pathology. Gastric Mucosa / surgery. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery
  • [MeSH-minor] Female. Humans. Laparotomy. Middle Aged. Neoplasm Staging

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17403360.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
  •  go-up   go-down


74. Angiero F, Gatta LB, Seramondi R, Berenzi A, Benetti A, Magistro S, Ordesi P, Grigolato P, Dessy E: Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer. Anticancer Res; 2010 Sep;30(9):3435-40
NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Frequency and role of HPV in the progression of epithelial dysplasia to oral cancer.
  • BACKGROUND: Human papillomavirus DNA (HPV DNA) and p16 and p53 protein expressions were investigated for their role in transforming dysplasia into squamous cell carcinoma of the oral cavity in a non-smoker and non-drinker patient group.
  • The specimens were grouped into three categories: group 1 included 31 cases of hyperplastic mucosa and mild dysplasia, group 2 included 14 cases of moderate and severe dysplasia, while group 3 comprised 11 cases of invasive squamous cell carcinomas.
  • [MeSH-major] Carcinoma, Squamous Cell / virology. Mouth Neoplasms / virology. Papillomavirus Infections / epidemiology. Precancerous Conditions / virology

  • Genetic Alliance. consumer health - Oral cancer.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20944119.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA, Viral; 0 / Tumor Suppressor Protein p53
  •  go-up   go-down


75. Kondakova IV, Cheremisina OV, Kakurina GV, Choĭnzonov EL: [Association of the degree of bronchial epithelial dysplasia to the serum level of non-enzymatic antioxidants]. Klin Lab Diagn; 2007 Dec;(12):23-4, 33
Hazardous Substances Data Bank. VITAMIN A .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Association of the degree of bronchial epithelial dysplasia to the serum level of non-enzymatic antioxidants].
  • The serum levels of non-enzymatic antioxidants were studied in patients with chronic nonspecific lung diseases with first-to-third-degree dysplasia of the bronchial epithelium (BE) before and after therapeutic correction.
  • During the therapy contributing to reversal of BE dysplastic alterations, there was an increase in the serum levels of vitamin A and uric acid in patients with simple chronic bronchitis with both first- and second-degree dysplasia.
  • [MeSH-major] Antioxidants / analysis. Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / etiology. Bronchitis, Chronic / complications. Uric Acid / blood. Vitamin A / blood
  • [MeSH-minor] Adult. Female. Humans. Male. Middle Aged. Neoplasm Staging

  • MedlinePlus Health Information. consumer health - Antioxidants.
  • MedlinePlus Health Information. consumer health - Chronic Bronchitis.
  • MedlinePlus Health Information. consumer health - Vitamin A.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18228666.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Antioxidants; 11103-57-4 / Vitamin A; 268B43MJ25 / Uric Acid
  •  go-up   go-down


76. Soni S, Kaur J, Kumar A, Chakravarti N, Mathur M, Bahadur S, Shukla NK, Deo SV, Ralhan R: Alterations of rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma. Oncology; 2005;68(4-6):314-25
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Alterations of rb pathway components are frequent events in patients with oral epithelial dysplasia and predict clinical outcome in patients with squamous cell carcinoma.
  • OBJECTIVE: This study was designed to test the hypothesis that alterations in expression of G1/S modulators cyclin D1, p16 and pRb occur in patients with oral epithelial dysplasia, considered to be at increased risk for malignant transformation.
  • PATIENTS AND METHODS: A prospective study was undertaken to carry out immunohistochemical analysis of cyclin D1, p16 and pRb proteins in serial paraffin-embedded tissue sections of 220 oral squamous cell carcinomas (OSCCs), 90 potentially malignant lesions (52 oral hyperplastic lesions, 38 dysplasias) and 81 matched histologically normal oral tissues and correlated them with clinicopathological parameters.
  • In a multivariate model, loss of pRb was associated with transition from hyperplasia to dysplasia (OR = 3.727, p = 0.005).
  • CONCLUSIONS: Deregulation of the p16/pRb/cyclin D1 pathway is an early event in acquisition of dysplasia, but deregulation of both pRb and p53 pathways is associated with malignant transformation and adverse prognosis in oral tumorigenesis.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Epithelial Cells / metabolism. Mouth Neoplasms / metabolism. Retinoblastoma Protein / metabolism
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Biomarkers, Tumor / metabolism. Case-Control Studies. Cyclin D1 / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Female. Humans. Leukoplakia, Oral / metabolism. Leukoplakia, Oral / pathology. Male. Middle Aged. Mouth Mucosa / metabolism. Mouth Mucosa / pathology. Neoplasm Invasiveness. Neoplasm Staging. Prognosis. Prospective Studies. Tumor Suppressor Protein p53 / metabolism


77. Chêne G, Penault-Llorca F, Le Bouëdec G, Mishellany F, Dauplat MM, Jaffeux P, Aublet-Cuvelier B, Pouly JL, Déchelotte P, Dauplat J: Ovarian epithelial dysplasia and prophylactic oophorectomy for genetic risk. Int J Gynecol Cancer; 2009 Jan;19(1):65-72
MedlinePlus Health Information. consumer health - Ovarian Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian epithelial dysplasia and prophylactic oophorectomy for genetic risk.
  • To make an accurate histopathological description of ovarian dysplasia in a population at genetic risk of ovarian cancer and devise an ovarian dysplasia score.
  • Eleven epithelial cytological and architectural features were defined.
  • An ovarian dysplasia score was devised to quantify extent of ovarian epithelial abnormalities.
  • The degrees of ovarian epithelial abnormalities (dysplasia scores) were compared between the two groups.
  • RESULTS: Mean dysplasia score was significantly higher in Group A (prophylactic oophorectomies) than in Group B (control group) (9.67 vs. 4.19, P < 0.001).
  • The ovarian dysplasia may be a pre-malignant, non-invasive histological lesion that could be an important step in early neoplasia.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19258944.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  •  go-up   go-down


78. Safadi RA, Musleh AS, Al-Khateeb TH, Hamasha AA: Analysis of immunohistochemical expression of k19 in oral epithelial dysplasia and oral squamous cell carcinoma using color deconvolution-image analysis method. Head Neck Pathol; 2010 Dec;4(4):282-9
Hazardous Substances Data Bank. HEMATOXYLIN .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Analysis of immunohistochemical expression of k19 in oral epithelial dysplasia and oral squamous cell carcinoma using color deconvolution-image analysis method.
  • The aim of the present study was to objectively analyze K19 immunoexpression in OSCC and to validate the utility of K19 in differentiation among grades of oral epithelial dysplasia (OED).
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Immunohistochemistry / methods. Keratin-19 / metabolism. Mouth Neoplasms / metabolism. Mouth Neoplasms / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Biopsy. Cell Differentiation. Eosine Yellowish-(YS). Epithelial Cells / metabolism. Epithelial Cells / pathology. Hematoxylin. Humans. Image Processing, Computer-Assisted / methods. Paraffin Embedding. Staining and Labeling / methods

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • Genetic Alliance. consumer health - Oral squamous cell carcinoma.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Oral Pathol Med. 2004 Feb;33(2):65-70 [14720191.001]
  • [Cites] Oral Surg Oral Med Oral Pathol. 1978 Oct;46(4):518-39 [280847.001]
  • [Cites] Scand J Dent Res. 1984 Oct;92(5):448-68 [6593810.001]
  • [Cites] Am J Pathol. 1989 Jan;134(1):89-98 [2464285.001]
  • [Cites] Am J Clin Pathol. 1989 Dec;92(6):836-43 [2480062.001]
  • [Cites] Cancer Res. 1991 Aug 1;51(15):3972-81 [1713123.001]
  • [Cites] J Oral Pathol Med. 1993 Apr;22(4):183-9 [7686226.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Aug;80(2):188-91 [7552884.001]
  • [Cites] J Cell Sci. 1996 May;109 ( Pt 5):1017-28 [8743949.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Aug;82(2):117 [8863297.001]
  • [Cites] Oral Dis. 1998 Jun;4(2):70-7 [9680893.001]
  • [Cites] J Biol Chem. 1998 Dec 25;273(52):35176-84 [9857055.001]
  • [Cites] BMC Cancer. 2006;6:10 [16412231.001]
  • [Cites] J Oral Pathol Med. 2006 Jul;35(6):369-75 [16762018.001]
  • [Cites] Oral Oncol. 2006 Nov;42(10):987-93 [16731030.001]
  • [Cites] Oncol Rep. 2007 Sep;18(3):639-43 [17671713.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Sep;104(3):377-84 [17095259.001]
  • [Cites] Kokubyo Gakkai Zasshi. 2007 Mar;73(3)-74(1):37-42 [17722467.001]
  • [Cites] J Oral Pathol Med. 2008 Mar;37(3):127-33 [18251935.001]
  • [Cites] J Cancer Res Clin Oncol. 2008 Apr;134(4):515-21 [17786476.001]
  • [Cites] Oral Oncol. 2009 Apr-May;45(4-5):309-16 [18804401.001]
  • [Cites] J Pathol. 2000 Mar;190(4):407-9 [10699986.001]
  • [Cites] Clin Dermatol. 2000 Sep-Oct;18(5):563-8 [11134851.001]
  • [Cites] Head Neck. 2001 Jul;23(7):536-43 [11400241.001]
  • [Cites] Anal Quant Cytol Histol. 2001 Aug;23(4):291-9 [11531144.001]
  • [Cites] Oral Oncol. 2002 Feb;38(2):125-30 [11854058.001]
  • [Cites] Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 May;37(3):187-90 [12419140.001]
  • [Cites] Community Dent Oral Epidemiol. 2003 Aug;31(4):300-5 [12846853.001]
  • (PMID = 20882374.001).
  • [ISSN] 1936-0568
  • [Journal-full-title] Head and neck pathology
  • [ISO-abbreviation] Head Neck Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-19; TDQ283MPCW / Eosine Yellowish-(YS); YKM8PY2Z55 / Hematoxylin
  • [Other-IDs] NLM/ PMC2996498
  •  go-up   go-down


79. Kobayashi M, Shibuya Y, Takeuchi J, Murata M, Suzuki H, Yokoo S, Umeda M, Minami Y, Komori T: Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2009 Mar;107(3):398-406
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity.
  • In this study, the expressions of Ror2 in the normal mucosa, the epithelium dysplasia, and squamous cell carcinoma (SCC) of the oral cavity were investigated, and possible differences in the expression patterns of Ror2 and of p53, Ki67, or PCNA were examined.
  • The tissue area with an Ror2-positive expression tended to differ from the area with a positive expression of p53, ki67, or PCNA, and the number of cells with an Ror2 expression tended to increase as the degree of malignancy rose in the epithelial tissues.
  • These results suggest that Ror2 was not related to cell proliferation, but rather associated with cell polarity and cell motility, and that it was also closely associated with the degree of malignancy in oral epithelial tissue.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Precancerous Conditions / metabolism. Receptor Protein-Tyrosine Kinases / biosynthesis. Receptors, Cell Surface / biosynthesis. Tongue Neoplasms / metabolism

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • Genetic Alliance. consumer health - Oral squamous cell carcinoma.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [CommentIn] Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jul;116(1):120 [23465658.001]
  • (PMID = 19217015.001).
  • [ISSN] 1528-395X
  • [Journal-full-title] Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • [ISO-abbreviation] Oral Surg Oral Med Oral Pathol Oral Radiol Endod
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proliferating Cell Nuclear Antigen; 0 / ROR2 protein, human; 0 / Receptors, Cell Surface; 0 / Tumor Suppressor Protein p53; EC 2.7.10.1 / Receptor Protein-Tyrosine Kinases; EC 2.7.10.1 / Receptor Tyrosine Kinase-like Orphan Receptors
  •  go-up   go-down


80. Angiero F, Berenzi A, Benetti A, Rossi E, Del Sordo R, Sidoni A, Stefani M, Dessy E: Expression of p16, p53 and Ki-67 proteins in the progression of epithelial dysplasia of the oral cavity. Anticancer Res; 2008 Sep-Oct;28(5A):2535-9
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Expression of p16, p53 and Ki-67 proteins in the progression of epithelial dysplasia of the oral cavity.
  • The samples included 18 cases of normal/hyperplastic mucosa, 25 cases of dysplasia and 11 cases of invasive squamous cell carcinoma.
  • The specimens were grouped into three categories: 1 = no or mild dysplasia, 2 = moderate or severe dysplasia, and 3 = invasive carcinoma.
  • In the group 2 specimens, the number of p16-, p53-, and Ki-67-positive cells increased as the grade of dysplasia progressed.
  • CONCLUSION: The expression of the cell-cycle proteins p16 and p53 in the dysplastic epithelium, in association with Ki-67, may represent significant markers to recognize evolution of precancerous disease in the oral cavity and to improve identification of the degree of dysplasia.
  • [MeSH-major] Biomarkers, Tumor / biosynthesis. Carcinoma, Squamous Cell / metabolism. Ki-67 Antigen / biosynthesis. Mouth Neoplasms / metabolism. Neoplasm Proteins / biosynthesis. Tumor Suppressor Protein p53 / biosynthesis


81. Chene G, Penault-Llorca F, Le Bouëdec G, Mishellany F, Dauplat MM, Jaffeux P, Aublet-Cuvelier B, Pouly JL, Dechelotte P, Dauplat J: Ovarian epithelial dysplasia after ovulation induction: time and dose effects. Hum Reprod; 2009 Jan;24(1):132-8
MedlinePlus Health Information. consumer health - Ovarian Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian epithelial dysplasia after ovulation induction: time and dose effects.
  • BACKGROUND: Ovarian epithelial dysplasia was first described after prophylactic oophorectomies for genetic risk.
  • In this study, we have investigated the risk of ovarian dysplasia after ovulation induction.
  • Eleven epithelial cytological and architectural features were defined and an ovarian epithelial dysplasia score was calculated to quantify the degree of ovarian epithelial abnormalities.
  • The mean ovarian dysplasia score was significantly higher in the ovulation induction group than in the control group (7.64 versus 3.62, P = 0.0002).
  • We also found a relationship between the number of ovulation-inducted cycles and the severity of ovarian dysplasia ('dose-effect') and a relationship between time after the end of ovulation induction (over 7 years) and the severity of ovarian dysplasia ('time-effect').
  • CONCLUSIONS: There is probably a relationship between ovarian epithelial dysplasia and either ovulation inducing drugs or infertility.
  • By Fathalla's incessant ovulation theory, 'the dose effect and the time effect' of ovarian stimulation may explain ovarian dysplasia formation.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / etiology. Ovarian Neoplasms / chemically induced. Ovulation Induction / adverse effects. Precancerous Conditions / chemically induced

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18824470.001).
  • [ISSN] 1460-2350
  • [Journal-full-title] Human reproduction (Oxford, England)
  • [ISO-abbreviation] Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  •  go-up   go-down


82. Wang GF, Lai MD, Yang RR, Chen PH, Su YY, Lv BJ, Sun LP, Huang Q, Chen SZ: Histological types and significance of bronchial epithelial dysplasia. Mod Pathol; 2006 Mar;19(3):429-37
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Histological types and significance of bronchial epithelial dysplasia.
  • Squamous dysplasia and atypical adenomatous hyperplasia have been identified and classified as preinvasive lesions of squamous cell carcinoma and peripheral pulmonary adenocarcinoma, respectively.
  • By examining 114 resection lung specimens, we concluded that there are four histological patterns of bronchial epithelial dysplasia based on morphological features (basal cell dysplasia, columnar cell dysplasia, bronchial epithelial dysplasia with transitional differentiation, and squamous dysplasia).
  • Basal cell dysplasia was focally positive for cytokeratin (CK) 17 and 10/13; columnar cell dysplasia was generally positive for CK7, 8, and 18; bronchial epithelial dysplasia with transitional differentiation had a heterogeneous immunoprofile, while squamous dysplasia was positive for CK10/13 and focally positive for CK17.
  • Various degrees of abnormal expression of p53 and Ki-67 were found in the different types of bronchial epithelial dysplasia.
  • The cases were divided into three groups based on degree and extent of bronchial epithelial dysplasia.
  • By Crosstabs McNemar test, the Mann-Whitney U-test (for two independent groups), the Kruskal-Wallis one-way nonparametric ANOVA (for >2 independent groups) and Spearman correlation analysis, the degree and extent of bronchial epithelial dysplasia was shown to be positively correlated with the incidence of bronchogenic carcinoma and multifocal primary lung carcinoma (P<0.05).
  • (1) bronchial epithelium can develop various patterns of dysplasia with abnormal/ambiguous cell differentiation and abnormal expressions of p53 and Ki-67.
  • Thus, these bronchial epithelial dysplastic lesions may represent a preneoplastic process. (2) The degree of bronchial epithelial dysplasia may significantly predispose individuals to bronchogenic carcinoma and multifocal primary lung carcinoma.
  • [MeSH-major] Lung Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Adult. Aged. Bronchial Neoplasms / metabolism. Bronchial Neoplasms / pathology. Carcinoma, Bronchogenic / metabolism. Carcinoma, Bronchogenic / pathology. Cell Differentiation. Epithelial Cells / chemistry. Epithelial Cells / pathology. Female. Humans. Immunohistochemistry. Keratins / analysis. Ki-67 Antigen / analysis. Male. Middle Aged. Respiratory Mucosa / chemistry. Respiratory Mucosa / pathology. Tumor Suppressor Protein p53 / analysis

  • MedlinePlus Health Information. consumer health - Lung Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16415791.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Tumor Suppressor Protein p53; 68238-35-7 / Keratins
  •  go-up   go-down


83. Just T, Lankenau E, Prall F, Hüttmann G, Pau HW, Sommer K: Optical coherence tomography allows for the reliable identification of laryngeal epithelial dysplasia and for precise biopsy: a clinicopathological study of 61 patients undergoing microlaryngoscopy. Laryngoscope; 2010 Oct;120(10):1964-70

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Optical coherence tomography allows for the reliable identification of laryngeal epithelial dysplasia and for precise biopsy: a clinicopathological study of 61 patients undergoing microlaryngoscopy.
  • OBJECTIVES/HYPOTHESIS: A newly developed microscope-based spectral-domain optical coherence tomography (SD-OCT) device and an endoscope-based time-domain OCT (TD-OCT) were used to assess the inter-rater reliability, sensitivity, specificity, and accuracy of benign and dysplastic laryngeal epithelial lesions.
  • RESULTS: Thickness of the epithelium was seen to be the main criterion for degree of dysplasia.
  • OCT provided test outcomes for differentiation between benign laryngeal lesions and dysplasia/CIS with sensitivity of 88%, specificity of 89%, PPV of 85%, NPV of 91%, and predictive accuracy of 88%.
  • CONCLUSIONS: OCT allows for a fairly accurate assessment of benign and dysplastic laryngeal epithelial lesion and greatly facilitates the taking of precise biopsies.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20824740.001).
  • [ISSN] 1531-4995
  • [Journal-full-title] The Laryngoscope
  • [ISO-abbreviation] Laryngoscope
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  •  go-up   go-down


84. Chêne G, Penault-Llorca F, Le Bouëdec G, Mishellany F, Dauplat MM, Tardieu AS, Pomel C, Jaffeux P, Aublet-Cuvelier B, Pouly JL, Déchelotte P, Dauplat J: [Ovarian epithelial dysplasia: myth or reality? Review]. Gynecol Obstet Fertil; 2008 Jul-Aug;36(7-8):800-7
MedlinePlus Health Information. consumer health - Ovarian Disorders.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Ovarian epithelial dysplasia: myth or reality? Review].
  • [Transliterated title] Dysplasie épithéliale ovarienne: mythe ou réalité? Revue de la littérature.
  • Ovarian epithelial dysplasia has been described in the ovarian surface epithelium by histologic, morphometric and nuclear profile studies.
  • Diagnosis and identification of ovarian dysplasia would certainly be useful to understand the early steps of ovarian carcinogenesis.
  • However, dysplasia in relation with ovulation induction seems to have a different pattern.
  • We report dysplasia definitions and the current clinical management.
  • [MeSH-major] Ovarian Diseases / pathology. Uterine Cervical Dysplasia / pathology
  • [MeSH-minor] Female. Genes, BRCA1. Genes, BRCA2. Humans. Immunohistochemistry. Ovarian Neoplasms / epidemiology. Ovarian Neoplasms / genetics. Ovulation

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18657463.001).
  • [ISSN] 1297-9589
  • [Journal-full-title] Gynécologie, obstétrique & fertilité
  • [ISO-abbreviation] Gynecol Obstet Fertil
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] France
  • [Number-of-references] 64
  •  go-up   go-down


85. Jaber MA: Tobacco smoking and alcohol consumption as risk factors for site-specific intraoral epithelial dysplasia. J Investig Clin Dent; 2010 Nov;1(2):101-7
MedlinePlus Health Information. consumer health - Smoking and Youth.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tobacco smoking and alcohol consumption as risk factors for site-specific intraoral epithelial dysplasia.
  • AIM: The aim of the present study was to evaluate the role of tobacco and alcohol as possible risk factors for oral epithelial dysplasia in the various oral subsites.
  • METHODS: Data were gathered from 630 patients with oral epithelial dysplasia in the United Arab Emirates between 1997 and 2007.
  • Odds ratios for oral epithelial dysplasia at various oral subsites were estimated using multiple logistic regression for each level of exposure of interest.
  • RESULTS: The results showed that in males, oral epithelial dysplasia of the labial mucosa and floor of the mouth were strongly associated with tobacco smoking.
  • In females, oral epithelial dysplasia of the floor of the mouth and tongue were the sites associated with tobacco smoking.
  • Alcohol was not a significant determinant of the sites of oral epithelial dysplasia in either sex.
  • CONCLUSION: Tobacco smoking has a significant role in determining the oral epithelial dysplasia subsites, but alcohol consumption is not a risk factor for oral epithelial dysplasia sites.
  • [MeSH-major] Alcohol Drinking / epidemiology. Mouth Mucosa / pathology. Mouth Neoplasms / epidemiology. Precancerous Conditions / epidemiology. Smoking / epidemiology
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Alcoholic Beverages / classification. Alcoholic Beverages / statistics & numerical data. Beer / classification. Beer / statistics & numerical data. Female. Humans. Lip Neoplasms / epidemiology. Male. Middle Aged. Mouth Floor / pathology. Risk Factors. Sex Factors. Tobacco Products / classification. Tobacco Products / statistics & numerical data. Tongue Neoplasms / epidemiology. United Arab Emirates / epidemiology. Wine / classification. Wine / statistics & numerical data. Young Adult

  • MedlinePlus Health Information. consumer health - Alcohol.
  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • MedlinePlus Health Information. consumer health - Smoking.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] © 2010 Blackwell Publishing Asia Pty Ltd.
  • (PMID = 25427265.001).
  • [ISSN] 2041-1626
  • [Journal-full-title] Journal of investigative and clinical dentistry
  • [ISO-abbreviation] J Investig Clin Dent
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Keywords] NOTNLM ; alcohol / mouth / oral epithelial dysplasia / risk factor / tobacco
  •  go-up   go-down


86. Jeong CW, Lee JH, Sohn SS, Ryu SW, Kim DK: Mitochondrial microsatellite instability in gastric cancer and gastric epithelial dysplasia as a precancerous lesion. Cancer Epidemiol; 2010 Jun;34(3):323-7
MedlinePlus Health Information. consumer health - Stomach Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Mitochondrial microsatellite instability in gastric cancer and gastric epithelial dysplasia as a precancerous lesion.
  • To clarify the role of genetic instability in the progression from gastric dysplasia to gastric cancer, mitochondrial microsatellite instability (mtMSI) was studied in gastric cancer and gastric dysplasia.
  • METHODS: DNA was isolated from paired normal and tumoral tissues in 24 patients with gastric dysplasia (low grade) and 49 patients with gastric cancer. mtMSI was analyzed using eight microsatellite markers. mtMSI in gastric dysplasia was studied prospectively to elucidate the relation between mtMSI and gastric carcinogenesis.
  • In gastric dysplasia, mtMSI was detected in 3 (12.5%) of 24 patients with gastric dysplasia. mtMSI-positive gastric dysplasia showed a poor prognosis statistically compared to mtMSI negative through progression to high-grade dysplasia or gastric cancer.
  • [MeSH-major] DNA, Mitochondrial / chemistry. Gastric Mucosa / pathology. Microsatellite Instability. Precancerous Conditions / genetics. Stomach Neoplasms / genetics

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20409774.001).
  • [ISSN] 1877-783X
  • [Journal-full-title] Cancer epidemiology
  • [ISO-abbreviation] Cancer Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
  •  go-up   go-down


87. Lee J, Lee SK, Lee BU, Lee HJ, Cho NP, Yoon JH, Choi HR, Lee SK, Kim EC: Upregulation of heme oxygenase-1 in oral epithelial dysplasias. Int J Oral Maxillofac Surg; 2008 Mar;37(3):287-92
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Upregulation of heme oxygenase-1 in oral epithelial dysplasias.
  • The expression of heme oxygenase-1 (HO-1), stress-related enzyme, is induced in leukaemia and some cancer tissues, but relatively little is known about the differential pattern of HO-1 expression and proliferation in premalignant lesions of the epithelial oral mucosa.
  • Immunohistochemical staining was used to examine the expression patterns of HO-1 and proliferating cell nuclear antigen (PCNA) in a series of normal mucosa and mild-to-severe cases of oral epithelial dysplasia (OED) and oral squamous cell carcinoma.
  • HO-1 and PCNA expression was correlated with the degree of epithelial dysplasia.
  • [MeSH-major] Heme Oxygenase-1 / analysis. Mouth Mucosa / enzymology. Mouth Neoplasms / enzymology. Precancerous Conditions / enzymology
  • [MeSH-minor] Adult. Aged. Carcinoma in Situ / enzymology. Carcinoma, Squamous Cell / enzymology. Cytoprotection / physiology. Epithelial Cells / enzymology. Female. Humans. Immunohistochemistry. Leukoplakia, Oral / enzymology. Male. Middle Aged. Proliferating Cell Nuclear Antigen / analysis. Retrospective Studies. Up-Regulation

  • MedlinePlus Health Information. consumer health - Oral Cancer.
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18272347.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Proliferating Cell Nuclear Antigen; EC 1.14.99.3 / Heme Oxygenase-1
  •  go-up   go-down


88. Foster KW, Liu Z, Nail CD, Li X, Fitzgerald TJ, Bailey SK, Frost AR, Louro ID, Townes TM, Paterson AJ, Kudlow JE, Lobo-Ruppert SM, Ruppert JM: Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene; 2005 Feb 24;24(9):1491-500
eagle-i research resources. PMID 15674344 (Special Collections) .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia.
  • KLF4/GKLF normally functions in differentiating epithelial cells, but also acts as a transforming oncogene in vitro.
  • When induced in basal keratinocytes, KLF4 rapidly abolished the distinctive properties of basal and parabasal epithelial cells.
  • KLF4 caused a transitory apoptotic response and the skin progressed through phases of hyperplasia and dysplasia.
  • By 6 weeks, lesions exhibited nuclear KLF4 and other morphologic and molecular similarities to squamous cell carcinoma in situ. p53 determined the patch size sufficient to establish lesions, as induction in a mosaic pattern produced skin lesions only when p53 was deficient.
  • The results suggest that KLF4 can function in the nucleus to induce squamous epithelial dysplasia, and indicate roles for p53 and epithelial-mesenchymal signaling in these early neoplastic lesions.

  • COS Scholar Universe. author profiles.
  • Addgene Non-profit plasmid repository. clones/clone libraries - Get Article's Plasmids - Addgene (subscription/membership/fee required).
  • Hazardous Substances Data Bank. DOXORUBICIN .
  • Jackson Laboratory JAX®Mice Database. culture/stock collections - FVB.Cg-Tg(tetO-KLF4)32831Rup/Mmjax (subscription/membership/fee required).
  • KOMP Repository. gene/protein/disease-specific - KOMP Repository (subscription/membership/fee required).
  • Mouse Genome Informatics (MGI). Mouse Genome Informatics (MGI) .
  • NCI CPTAC Assay Portal. NCI CPTAC Assay Portal .
  • SciCrunch. Marmoset Gene list: Data: Gene Annotation .
  • The Lens. Cited by Patents in .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] J Biol Chem. 2001 Jul 20;276(29):26737-40 [11389134.001]
  • [Cites] Cancer Surv. 1998;32:69-113 [10489624.001]
  • [Cites] Curr Opin Cell Biol. 2001 Dec;13(6):778-84 [11698196.001]
  • [Cites] Nat Genet. 2001 Dec;29(4):418-25 [11694875.001]
  • [Cites] N Engl J Med. 2001 Dec 27;345(26):1890-900 [11756581.001]
  • [Cites] Development. 2002 Jun;129(11):2619-28 [12015290.001]
  • [Cites] J Invest Dermatol. 2002 Jun;118(6):998-1002 [12060394.001]
  • [Cites] Trends Cell Biol. 2001 Nov;11(11):S2-9 [11684435.001]
  • [Cites] Nucleic Acids Res. 1999 Dec 1;27(23):4562-9 [10556311.001]
  • [Cites] Cell. 2000 Jan 7;100(1):57-70 [10647931.001]
  • [Cites] J Biol Chem. 2000 Jun 16;275(24):18391-8 [10749849.001]
  • [Cites] Nucleic Acids Res. 2000 Aug 1;28(15):2969-76 [10908361.001]
  • [Cites] J Biol Chem. 2000 Dec 1;275(48):37798-806 [10954723.001]
  • [Cites] Cancer Res. 2000 Nov 15;60(22):6488-95 [11103818.001]
  • [Cites] Nature. 2001 Apr 26;410(6832):1111-6 [11323676.001]
  • [Cites] Cancer Res. 2002 Oct 15;62(20):5867-73 [12384550.001]
  • [Cites] Cell. 2002 Oct 18;111(2):241-50 [12408868.001]
  • [Cites] J Biol Chem. 2003 Mar 28;278(13):11661-9 [12538588.001]
  • [Cites] Cancer Cell. 2003 Mar;3(3):203-5 [12676578.001]
  • [Cites] Development. 2003 Jun;130(12):2767-77 [12736219.001]
  • [Cites] Oncogene. 2003 May 29;22(22):3424-30 [12776194.001]
  • [Cites] Curr Opin Cell Biol. 2003 Dec;15(6):763-70 [14644203.001]
  • [Cites] Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G23-30 [12919939.001]
  • [Cites] Cancer Cell. 2003 Nov;4(5):383-91 [14667505.001]
  • [Cites] Cancer Cell. 2003 Dec;4(6):425-9 [14706334.001]
  • [Cites] Oncogene. 2004 Jan 15;23(2):395-402 [14724568.001]
  • [Cites] Cell. 2004 Jan 23;116(2):235-46 [14744434.001]
  • [Cites] Cancer Cell. 2004 Apr;5(4):311-6 [15093538.001]
  • [Cites] Clin Cancer Res. 2004 Apr 15;10(8):2709-19 [15102675.001]
  • [Cites] Clin Cancer Res. 2004 Jun 1;10(11):3815-24 [15173090.001]
  • [Cites] Anal Biochem. 1987 Apr;162(1):156-9 [2440339.001]
  • [Cites] J Cell Sci. 1987 Oct;88 ( Pt 3):305-12 [3129440.001]
  • [Cites] Cancer Res. 1989 Jul 15;49(14):3713-21 [2660980.001]
  • [Cites] Cell Differ Dev. 1990 Apr;30(1):27-34 [2350734.001]
  • [Cites] Cell. 1990 Jun 15;61(6):1147-55 [2161707.001]
  • [Cites] Nature. 1991 Jul 25;352(6333):345-7 [1852210.001]
  • [Cites] Nature. 1992 Mar 19;356(6366):215-21 [1552940.001]
  • [Cites] Cell. 1993 Sep 10;74(5):813-22 [8374952.001]
  • [Cites] Cancer Res. 1993 Oct 1;53(19):4477-80 [8402617.001]
  • [Cites] J Virol. 1994 Jul;68(7):4358-68 [7515971.001]
  • [Cites] Nature. 1994 Dec 22-29;372(6508):773-6 [7997263.001]
  • [Cites] Nucleic Acids Res. 1995 May 25;23(10):1686-90 [7784172.001]
  • [Cites] Cancer Metastasis Rev. 1995 Jun;14(2):113-24 [7554029.001]
  • [Cites] Methods Enzymol. 1995;254:3-20 [8531694.001]
  • [Cites] Science. 1996 Jun 14;272(5268):1621-5 [8658135.001]
  • [Cites] Science. 1996 Jun 14;272(5268):1668-71 [8658145.001]
  • [Cites] J Cell Biochem. 1995 Dec;59(4):463-72 [8749716.001]
  • [Cites] J Biol Chem. 1996 Aug 16;271(33):20009-17 [8702718.001]
  • [Cites] J Biol Chem. 1996 Dec 6;271(49):31384-90 [8940147.001]
  • [Cites] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14025-9 [8943054.001]
  • [Cites] Am J Pathol. 1996 Dec;149(6):1899-917 [8952526.001]
  • [Cites] Nature. 1997 Apr 24;386(6627):761, 763 [9126728.001]
  • [Cites] Eur Arch Otorhinolaryngol. 1997;254(8):376-83 [9332893.001]
  • [Cites] FEBS Lett. 1997 Dec 15;419(2-3):239-43 [9428642.001]
  • [Cites] J Biol Chem. 1998 Apr 24;273(17):10747-54 [9553140.001]
  • [Cites] J Biol Chem. 1998 Jul 10;273(28):17917-25 [9651398.001]
  • [Cites] J Cell Biol. 1998 Oct 19;143(2):469-86 [9786956.001]
  • [Cites] J Cell Biochem Suppl. 1998;30-31:111-22 [9893262.001]
  • [Cites] Oncogene. 1999 Jun 17;18(24):3593-607 [10380881.001]
  • [Cites] Cell Growth Differ. 1999 Jun;10(6):423-34 [10392904.001]
  • [Cites] Nat Genet. 1999 Aug;22(4):356-60 [10431239.001]
  • [Cites] Nature. 2001 May 17;411(6835):349-54 [11357142.001]
  • (PMID = 15674344.001).
  • [ISSN] 0950-9232
  • [Journal-full-title] Oncogene
  • [ISO-abbreviation] Oncogene
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P30CA13148; United States / NCI NIH HHS / CA / P50 CA089019; United States / NCI NIH HHS / CA / P30 CA013148; United States / NCI NIH HHS / CA / R01 CA094030; United States / NCI NIH HHS / CA / R29 CA065686; United States / NCI NIH HHS / CA / CA89019; United States / NCI NIH HHS / CA / R01 CA065686; United States / NCI NIH HHS / CA / CA65686; United States / NCI NIH HHS / CA / CA094030
  • [Publication-type] Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA Primers; 0 / DNA-Binding Proteins; 0 / GKLF protein; 0 / Kruppel-Like Transcription Factors; 0 / Transcription Factors; 80168379AG / Doxorubicin
  • [Other-IDs] NLM/ NIHMS7908; NLM/ PMC1361530
  •  go-up   go-down


89. Ogbureke KU, Abdelsayed RA, Kushner H, Li L, Fisher LW: Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma. Cancer; 2010 Apr 1;116(7):1709-17
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma.
  • RESULTS: : The OPL patient population was representative of previous studies with 20% progressing to OSCC, and no correlation between degree of dysplasia and progression.

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • Genetic Alliance. consumer health - Oral squamous cell carcinoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Cites] Oral Oncol. 2000 May;36(3):253-5 [10793326.001]
  • [Cites] Cancer Res. 2008 May 1;68(9):3099-107 [18451134.001]
  • [Cites] BMJ. 2000 Jul 22;321(7255):225-8 [10903660.001]
  • [Cites] Int J Oral Maxillofac Surg. 2001 Feb;30(1):49-53 [11289621.001]
  • [Cites] Cancer. 2001 Nov 1;92(9):2349-56 [11745290.001]
  • [Cites] Crit Rev Oral Biol Med. 2003;14(1):47-62 [12764019.001]
  • [Cites] Connect Tissue Res. 2003;44 Suppl 1:33-40 [12952171.001]
  • [Cites] J Dent Res. 2004 Sep;83(9):664-70 [15329369.001]
  • [Cites] Cancer. 1975 Oct;36(4):1386-92 [1175136.001]
  • [Cites] Cancer. 1975 Sep;36(3):1021-8 [1182656.001]
  • [Cites] Cancer. 1976 Oct;38(4):1790-5 [1033027.001]
  • [Cites] Oral Surg Oral Med Oral Pathol. 1976 Dec;42(6):766-74 [1069220.001]
  • [Cites] Oral Surg Oral Med Oral Pathol. 1977 Mar;43(3):383-90 [265042.001]
  • [Cites] Community Dent Oral Epidemiol. 1980;8(6):283-333 [6937277.001]
  • [Cites] Cancer. 1984 Feb 1;53(3):563-8 [6537892.001]
  • [Cites] J Exp Med. 1990 Oct 1;172(4):1177-83 [1976736.001]
  • [Cites] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Mar;79(3):321-9 [7621010.001]
  • [Cites] Oral Oncol. 1997 Sep;33(5):317-21 [9415329.001]
  • [Cites] J Pathol. 1998 Apr;184(4):360-8 [9664901.001]
  • [Cites] J Oral Pathol Med. 1999 Mar;28(3):97-101 [10069535.001]
  • [Cites] Kidney Int. 2005 Jul;68(1):155-66 [15954904.001]
  • [Cites] J Oral Pathol Med. 2007 Jan;36(1):25-9 [17181738.001]
  • [Cites] J Histochem Cytochem. 2007 Apr;55(4):403-9 [17210923.001]
  • [Cites] Oral Oncol. 2007 Oct;43(9):920-32 [17306612.001]
  • [Cites] J Oral Pathol Med. 2008 Jan;37(1):1-10 [18154571.001]
  • [Cites] J Oral Pathol Med. 2008 Mar;37(3):127-33 [18251935.001]
  • [Cites] Nat Rev Cancer. 2008 Mar;8(3):212-26 [18292776.001]
  • [Cites] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387.001]
  • [Cites] Br J Oral Maxillofac Surg. 2008 Apr;46(3):187-91 [18096283.001]
  • [Cites] Clin Cancer Res. 2000 May;6(5):1702-10 [10815888.001]
  • (PMID = 20186700.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / DE017791-05; United States / NIDCR NIH HHS / DE / K23 DE017791-05; United States / NIDCR NIH HHS / DE / K23DE017791-01A1; United States / Intramural NIH HHS / / ; United States / NIDCR NIH HHS / DE / K23 DE017791; United States / NIDCR NIH HHS / DE / K23 DE017791-01A1; United States / NIDCR NIH HHS / DE / DE017791-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / IBSP protein, human; 0 / Integrin-Binding Sialoprotein; 0 / Phosphoproteins; 0 / Sialoglycoproteins; 0 / dentin sialophosphoprotein
  • [Other-IDs] NLM/ NIHMS164598; NLM/ PMC2847022
  •  go-up   go-down


90. Sousa FA, Paradella TC, Brandão AA, Rosa LE: Oral lichen planus versus epithelial dysplasia: difficulties in diagnosis. Braz J Otorhinolaryngol; 2009 Sep-Oct;75(5):716-20
Genetic Alliance. consumer health - Oral lichen planus.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Oral lichen planus versus epithelial dysplasia: difficulties in diagnosis.
  • Histopathological diagnosis of oral lichen planus is not easy since some cases of epithelial dysplasia may present traits which are very similar to those from lichen planus.
  • AIM: to compare cell alterations which suggest malignancy present in oral lichen planus with those from epithelial dysplasia.
  • MATERIAL AND METHODS: histological cross-sections of oral lichen planus and dysplasia, dyed by hematoxylin-eosin, were analyzed by means of light microscopy.
  • RESULTS: variance analysis (alpha=5%) revealed a statistically significant difference between the average number of cell alterations in the lichen planus (5.83 + or - 1.61) and epithelial dysplasia (4.46 + or - 1.26).
  • The chi-squared test did not show statistically significant differences between oral lichen planus and epithelial dysplasia in relation to the following cell alterations: increase in nucleus/cytoplasm ratio, nuclear hyperchromatism, irregular chromatin distribution and enlarged nuclei (p>0.05).
  • CONCLUSION: Some cell alterations which suggest malignancy present in the oral lichen planus may also be found in epithelial dysplasia, impairing its diagnosis and, consequently, stressing the importance of following these patients in the long run.
  • [MeSH-major] Epithelial Cells / pathology. Lichen Planus, Oral / pathology. Mouth Mucosa / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19893941.001).
  • [ISSN] 1808-8686
  • [Journal-full-title] Brazilian journal of otorhinolaryngology
  • [ISO-abbreviation] Braz J Otorhinolaryngol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Brazil
  •  go-up   go-down


91. Wang GF, Lai MD, Chen PH: [Correlation of multiple primary lung cancer with bronchial and alveolar epithelial dysplasia]. Zhejiang Da Xue Xue Bao Yi Xue Ban; 2005 Sep;34(5):427-31
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Correlation of multiple primary lung cancer with bronchial and alveolar epithelial dysplasia].
  • OBJECTIVE: To investigate the correlation of multiple primary lung cancer with bronchial epithelial dysplasia and atypical adenomatous hyperplasia of bronchiolo-alveolar epithelium.
  • The correlation of multiple primary lung cancer with bronchial epithelial dysplasia and atypical adenomatous hyperplasia of bronchiolo-alveolar epithelium was analyzed.
  • The rate of multiple primary lung cancers was significantly higher in individuals with high grade bronchial epithelial dysplasia than in those with low grade dysplasia (r=0.238, P<0.05).
  • CONCLUSION: Bronchial and alveolar epithelial cells may develop malignancy synchronously or metachronously.
  • The probability of developing multiple primary lung cancer will increase in the lungs with extensive and severe bronchial epithelial dysplasia.
  • [MeSH-major] Bronchi / pathology. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Pulmonary Alveoli / pathology

  • Genetic Alliance. consumer health - Lung Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16216054.001).
  • [ISSN] 1008-9292
  • [Journal-full-title] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
  • [ISO-abbreviation] Zhejiang Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


92. Maeda K, Yamashiro M, Michi Y, Suzuki T, Ohyama Y, Okada N, Amagasa T: Effective staining method with iodine for leukoplakia and lesions surrounding squamous cell carcinomas of the tongue assessed by colorimetric analysis. J Med Dent Sci; 2009 Dec;56(4):123-30
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Color difference values (DeltaE*ab) using 3% and 5% Lugol solutions were significantly different between epithelial hyperplasia/mild epithelial dysplasia and moderate to severe dysplasia (P < 0.05).
  • These results suggest that the most effective method for obtaining a clear boundary and distinguishing moderate to severe dysplasia from mild or no epithelial dysplasia according to the measured color value was to stain with 3% followed by 5% Lugol solution.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Colorimetry / methods. Coloring Agents. Iodides. Leukoplakia, Oral / diagnosis. Tongue Neoplasms / diagnosis

  • Genetic Alliance. consumer health - Leukoplakia.
  • Hazardous Substances Data Bank. Gentian Violet .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 20432796.001).
  • [ISSN] 1342-8810
  • [Journal-full-title] Journal of medical and dental sciences
  • [ISO-abbreviation] J. Med. Dent. Sci.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Iodides; J4Z741D6O5 / Gentian Violet; T66M6Y3KSA / Lugol's solution
  •  go-up   go-down


93. Lin ZH, Shen XH, Jin Z, Kim Y, Lee E, Kim H, Kim I: Human papillomavirus genotyping by oligonucleotide microarray and p16 expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in Korean women. Pathol Int; 2005 Aug;55(8):491-6
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Human papillomavirus genotyping by oligonucleotide microarray and p16 expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in Korean women.
  • For evaluating the diagnostic significance of p16(INK4A) over-expression in the uterine cervical intraepithelial neoplasm and in invasive carcinoma, human papillomavirus (HPV) was detected and genotyped by oligonucleotide microarray in archival tissues of 117 cervical specimens, including 47 invasive squamous cell carcinomas (SCC), 30 cases of cervical intraepithelial neoplasia (CIN), 20 adenocarcinomas, and 20 cases of non-neoplastic cervix.
  • In conclusion, the presence of p16(INK4A) expression in cervical squamous and glandular epithelium indicates the existence of dysplasia or malignancy in the uterine cervix, regardless of HPV infection.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / virology. Cyclin-Dependent Kinase Inhibitor p16 / genetics. Papillomaviridae / genetics. Papillomavirus Infections / virology. Uterine Cervical Neoplasms / virology
  • [MeSH-minor] Adenocarcinoma / genetics. Adenocarcinoma / metabolism. Adenocarcinoma / virology. Carcinoma, Squamous Cell / genetics. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / virology. Cell Line, Tumor. Female. Gene Expression Regulation, Neoplastic. Genotype. HeLa Cells. Humans. Korea. Neoplasm Invasiveness. Oligonucleotide Array Sequence Analysis / methods. Polymerase Chain Reaction / methods

  • MedlinePlus Health Information. consumer health - Cervical Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 15998377.001).
  • [ISSN] 1320-5463
  • [Journal-full-title] Pathology international
  • [ISO-abbreviation] Pathol. Int.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16
  •  go-up   go-down


94. Tsai HT, Wu CH, Lai HL, Li RN, Tung YC, Chuang HY, Wu TN, Lin LJ, Ho CK, Liu HW, Wu MT: Association between quantitative high-risk human papillomavirus DNA load and cervical intraepithelial neoplasm risk. Cancer Epidemiol Biomarkers Prev; 2005 Nov;14(11 Pt 1):2544-9
The Lens. Cited by Patents in .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Association between quantitative high-risk human papillomavirus DNA load and cervical intraepithelial neoplasm risk.
  • Human papillomavirus (HPV) infection is a high-risk factor for cervical intraepithelial neoplasm (CIN) but the association between the quantitative HPV DNA load and the severity of CIN remains controversial.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / etiology. Cervical Intraepithelial Neoplasia / virology. Human papillomavirus 16 / genetics. Papillomavirus Infections / complications. Uterine Cervical Neoplasms / etiology. Uterine Cervical Neoplasms / virology. Viral Load

  • MedlinePlus Health Information. consumer health - Cervical Cancer.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16284376.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / DNA, Viral
  •  go-up   go-down


95. Hagiwara S, Hirayama M, Takahashi T, Meguro T, Morita T, Horita S, Niitsu Y: [Undifferentiated pleomorphic sarcoma detected in the descending colon: report of a case]. Nihon Shokakibyo Gakkai Zasshi; 2008 May;105(5):692-8
MedlinePlus Health Information. consumer health - Soft Tissue Sarcoma.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Main occupied lesion of the tumor was mesenterium and submucosa, with no epithelial dysplasia.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Peritoneal Neoplasms / secondary. Sarcoma / surgery

  • Genetic Alliance. consumer health - Pleomorphic Undifferentiated Sarcoma.
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 18460858.001).
  • [ISSN] 0446-6586
  • [Journal-full-title] Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • [ISO-abbreviation] Nihon Shokakibyo Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 30
  •  go-up   go-down


96. Colović R, Grubor N, Radak V, Micev M, Colović N, Stojković M: [Tubular adenoma of the gallbladder with squamous metaplasia]. Srp Arh Celok Lek; 2006 Mar-Apr;134(3-4):159-61
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Histology showed tubular adenoma with mild epithelial dysplasia in some places and with antral and squamous metaplasia.
  • [MeSH-major] Adenoma / pathology. Gallbladder Neoplasms / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16915759.001).
  • [ISSN] 0370-8179
  • [Journal-full-title] Srpski arhiv za celokupno lekarstvo
  • [ISO-abbreviation] Srp Arh Celok Lek
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia and Montenegro
  •  go-up   go-down


97. Roa I, de Aretxabala X, Araya JC, Roa J: Preneoplastic lesions in gallbladder cancer. J Surg Oncol; 2006 Jun 15;93(8):615-23
MedlinePlus Health Information. consumer health - Gallbladder Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The knowledge regarding the etiology and mechanisms through which this neoplasia is developed is significantly less compared to other malignant tumors.
  • RESULTS: The epithelial lesions involved in gallbladder carcinogenesis are dysplasia and adenomas that represent two biologically distinct carcinogenetic models.
  • Dysplasia progresses to carcinoma in situ (CIS) and subsequently becomes invasive.
  • Over 80% of invasive gallbladder cancers present areas adjacent to the CIS and epithelial dysplasia.
  • Epithelial dysplasia which is not associated with gallbladder cancer is observed in approximately 1% of cholecystectomies for symptomatic lithiasis.
  • Metaplasia, dysplasia, and CIS are present in the mucosa adjacent to the cancer in 66%, 81.3%, and 69%, respectively.
  • The average ages of patients with dysplasia not associated to cancer (51.9 years), early carcinomas (56.8 years), and advanced carcinomas (62.9 years) demonstrate a gradient which suggests the progression of these lesions.
  • CONCLUSIONS: From the morphological point of view, the dysplasia-carcinoma sequence is the most plausible carcinogenic pathway for gallbladder cancer, a process which would require a period of approximately 10 years.
  • [MeSH-major] Adenoma / pathology. Carcinoma in Situ / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology. Precancerous Conditions / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16724345.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 86
  •  go-up   go-down


98. Yu H, Li X, Wang Y, Yang H, Guo X, Pan Z, Jiang X: [Clinic and pathological analysis the larynx leukoplakia in 74 cases]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2009 Aug;23(15):688-9
Genetic Alliance. consumer health - Leukoplakia.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Fifty-six cases were leukoplakia with epithelial dysplasia histologically.
  • The patients with histological epithelial dysplasia should be pay great attention because of their higher canceration rate, and enlarged operation ranges appropriately with the patient consent could effectually prevent recurrence or canceration during the early lesions.

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 19947253.001).
  • [ISSN] 1001-1781
  • [Journal-full-title] Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
  • [ISO-abbreviation] Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  •  go-up   go-down


99. Li C, Shintani S, Terakado N, Klosek SK, Ishikawa T, Nakashiro K, Hamakawa H: Microvessel density and expression of vascular endothelial growth factor, basic fibroblast growth factor, and platelet-derived endothelial growth factor in oral squamous cell carcinomas. Int J Oral Maxillofac Surg; 2005 Jul;34(5):559-65
MedlinePlus Health Information. consumer health - Oral Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Microvessel density did not differ significantly between normal oral mucosa and epithelial dysplasia, but was significantly increased in tumor tissues.
  • [MeSH-major] Carcinoma, Squamous Cell / blood supply. Fibroblast Growth Factor 2 / analysis. Mouth Neoplasms / blood supply. Thymidine Phosphorylase / analysis. Vascular Endothelial Growth Factor A / analysis
  • [MeSH-minor] Adult. Aged. Angiogenesis Inducing Agents / analysis. Cell Differentiation. Epithelium / blood supply. Epithelium / pathology. Female. Humans. Male. Microcirculation / pathology. Middle Aged. Mouth Mucosa / blood supply. Mouth Mucosa / pathology. Neoplasm Invasiveness. Neoplasm Staging. Neovascularization, Pathologic / pathology. Platelet-Derived Growth Factor / analysis. Precancerous Conditions / blood supply. Precancerous Conditions / pathology

  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 16053878.001).
  • [ISSN] 0901-5027
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Angiogenesis Inducing Agents; 0 / Platelet-Derived Growth Factor; 0 / Vascular Endothelial Growth Factor A; 103107-01-3 / Fibroblast Growth Factor 2; EC 2.4.2.4 / Thymidine Phosphorylase
  •  go-up   go-down


100. Li SY, Dai J, Hu JA: [Expression of pJAK, pERK and Cyclin D1 proteins in squamous-cell carcinoma of tongue]. Zhejiang Da Xue Xue Bao Yi Xue Ban; 2007 Jul;36(4):396-400
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • METHODS: The expression of JAK, ERK and Cyclin D1 proteins was determined with SP immunohistochemical method in 30 cases of lingual Squamous cell carcinoma, 20 of normal lingual mucosa, 10 of mild epithelial dysplasia and 20 of severe epithelial dysplasia.
  • RESULTS: The expression of pJAK in lingual squamous-cell carcinoma and epithelial dysplasia was stronger than that of normal lingual mucosa (chi2=37.54, P<0.01), and the expression of pJAK in lingual squamous-cell carcinoma was significantly higher than that of the epithelial dysplasia (chi2=6.83, P<0.05).
  • There was no significant difference in pERK expression among lingual squamous-cell carcinoma, normal lingual mucosa and epithelial dysplasia.
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Cyclin D1 / metabolism. Extracellular Signal-Regulated MAP Kinases / metabolism. Janus Kinases / metabolism. Tongue Neoplasms / metabolism

  • Genetic Alliance. consumer health - Carcinoma, Squamous Cell.
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .
  • [Email] Email this result item
    Email the results to the following email address:   [X] Close
  • (PMID = 17717834.001).
  • [ISSN] 1008-9292
  • [Journal-full-title] Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
  • [ISO-abbreviation] Zhejiang Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 136601-57-5 / Cyclin D1; EC 2.7.10.2 / Janus Kinases; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  •  go-up   go-down






Advertisement