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1. Hampl M, Sarajuuri H, Wentzensen N, Bender HG, Kueppers V: Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer. Obstet Gynecol; 2006 Dec;108(6):1361-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Effect of human papillomavirus vaccines on vulvar, vaginal, and anal intraepithelial lesions and vulvar cancer.
  • OBJECTIVE: Human papillomavirus (HPV) is a necessary cause for cervical cancer, and it has been associated with vulvar and vaginal cancer and vulvar (VIN) and vaginal (VaIN) and anal (AIN) intraepithelial neoplasia.
  • RESULTS: The analyses were performed on 210 intraepithelial neoplasia samples (VIN2/3, VaIN2/3, AIN2/3) and 48 vulvar carcinoma samples.
  • CONCLUSION: Based on the data obtained in this study, widely-implemented prophylactic HPV vaccination could make an important contribution to the reduction of the risk for cervical cancer and could also prevent about half the vulvar carcinomas in younger women and about two thirds of the intraepithelial lesions in the lower genital tract.
  • [MeSH-major] Carcinoma in Situ / prevention & control. Papillomavirus Vaccines / therapeutic use. Vaginal Neoplasms / prevention & control. Vulvar Neoplasms / prevention & control


2. Fillies T, Jogschies M, Kleinheinz J, Brandt B, Joos U, Buerger H: Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma. Oncol Rep; 2007 Sep;18(3):639-43
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  • One hundred and ninety-two patients with OSCC, 117 patients with oral leukoplakia without dysplasia (OL) and 23 with oral leukoplakia with dysplasia (squamous intraepithelial neoplasia) (OLD) of the oral cavity were investigated for the immunohistochemical expression of Ck 5-6, Ck 8/18, Ck 1 Ck 10, Ck 14, Ck 19 using the tissue microarray technique.
  • The expression of Ck 8/18, Ck 19 and Ck 1 was seen in 3.1% (Ck 8/18), 12.5% (Ck 19), 75.4% (Ck 1) of all leukoplakias, 1.0% (Ck 8/18), 9.4% (Ck 19), 76.8% (Ck 1) in OL, 13.0% (Ck 8/18), 27.3% (Ck 19), 68.4% (Ck 1) in OLD and was significantly associated with the degree of dysplasia (Ck 8/18 p<0.01; Ck 19 p<0.01; Ck 1 p<0.01) and the acquisition of invasive growth properties.
  • These results can be interpreted as first hints that oral leukoplakias with an expression of Ck 8/18 or 19 independent of dysplasia, should be resected totally since they might indicate an increased progression potential.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Keratins / metabolism. Leukoplakia / pathology. Mouth Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Staging


3. Garland SM, Hernandez-Avila M, Wheeler CM, Perez G, Harper DM, Leodolter S, Tang GW, Ferris DG, Steben M, Bryan J, Taddeo FJ, Railkar R, Esser MT, Sings HL, Nelson M, Boslego J, Sattler C, Barr E, Koutsky LA, Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators: Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med; 2007 May 10;356(19):1928-43
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  • The coprimary composite end points were the incidence of genital warts, vulvar or vaginal intraepithelial neoplasia, or cancer and the incidence of cervical intraepithelial neoplasia, adenocarcinoma in situ, or cancer associated with HPV type 6, 11, 16, or 18.
  • [MeSH-major] Alphapapillomavirus. Carcinoma in Situ / prevention & control. Condylomata Acuminata / prevention & control. Genital Neoplasms, Female / prevention & control. Papillomavirus Infections / prevention & control. Papillomavirus Vaccines


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4. Chene G, Penault-Llorca F, Le Bouëdec G, Mishellany F, Dauplat MM, Jaffeux P, Aublet-Cuvelier B, Pouly JL, Dechelotte P, Dauplat J: Ovarian epithelial dysplasia after ovulation induction: time and dose effects. Hum Reprod; 2009 Jan;24(1):132-8
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  • [Title] Ovarian epithelial dysplasia after ovulation induction: time and dose effects.
  • BACKGROUND: Ovarian epithelial dysplasia was first described after prophylactic oophorectomies for genetic risk.
  • In this study, we have investigated the risk of ovarian dysplasia after ovulation induction.
  • Eleven epithelial cytological and architectural features were defined and an ovarian epithelial dysplasia score was calculated to quantify the degree of ovarian epithelial abnormalities.
  • The mean ovarian dysplasia score was significantly higher in the ovulation induction group than in the control group (7.64 versus 3.62, P = 0.0002).
  • We also found a relationship between the number of ovulation-inducted cycles and the severity of ovarian dysplasia ('dose-effect') and a relationship between time after the end of ovulation induction (over 7 years) and the severity of ovarian dysplasia ('time-effect').
  • CONCLUSIONS: There is probably a relationship between ovarian epithelial dysplasia and either ovulation inducing drugs or infertility.
  • By Fathalla's incessant ovulation theory, 'the dose effect and the time effect' of ovarian stimulation may explain ovarian dysplasia formation.
  • [MeSH-major] Neoplasms, Glandular and Epithelial / etiology. Ovarian Neoplasms / chemically induced. Ovulation Induction / adverse effects. Precancerous Conditions / chemically induced

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  • (PMID = 18824470.001).
  • [ISSN] 1460-2350
  • [Journal-full-title] Human reproduction (Oxford, England)
  • [ISO-abbreviation] Hum. Reprod.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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5. Pech O, May A, Gossner L, Rabenstein T, Manner H, Huijsmans J, Vieth M, Stolte M, Berres M, Ell C: Curative endoscopic therapy in patients with early esophageal squamous-cell carcinoma or high-grade intraepithelial neoplasia. Endoscopy; 2007 Jan;39(1):30-5
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  • [Title] Curative endoscopic therapy in patients with early esophageal squamous-cell carcinoma or high-grade intraepithelial neoplasia.
  • BACKGROUND AND STUDY AIMS: Endoscopic resection of esophageal squamous-cell neoplasia with curative intent is considered to be a safe and effective alternative treatment to radical surgery in cases where the neoplasia is intraepithelial or limited to the mucosal layer.
  • We conducted a prospective study to evaluate the efficacy and safety of endoscopic resection and to analyze variables associated with recurrence in patients with mucosal or intraepithelial squamous-cell neoplasia.
  • PATIENTS AND METHODS: Between December 1997 and September 2005, 65 patients (mean age +/- standard deviation [SD] 62.9 +/- 9.5 years), 12 with high-grade intraepithelial neoplasia (HGIN) and 53 with mucosal squamous-cell cancer, were included in our study and were treated using endoscopic resection.
  • [MeSH-major] Carcinoma in Situ / therapy. Esophageal Neoplasms / therapy. Esophagoscopy
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prospective Studies


6. Zhang S, Pavlovitz B, Tull J, Wang Y, Deng FM, Fuller C: Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization. Diagn Mol Pathol; 2010 Sep;19(3):151-6
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  • [Title] Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization.
  • In this study, we examined adenocarcinomas, prostatic intraepithelial neoplasia (PIN), and normal epithelium of the prostate retrieved from radical prostatectomy specimens to determine the frequency, specificity, tissue heterogeneity, and prognostic value of TMPRSS2 genetic alterations using a direct-labeled TMPRSS2 dual-color break-apart fluorescence in situ hybridization (FISH) probe cocktail designed to detect all known TMPRSS2-associated deletions or translocations.
  • TMPRSS2 genetic alterations detectable by this method are strictly restricted in prostate neoplasia, and can be identified in the majority of prostate carcinomas.
  • [MeSH-major] Epithelium / pathology. In Situ Hybridization, Fluorescence / methods. Pathology, Molecular / methods. Prostate / pathology. Prostatic Neoplasms / pathology. Serine Endopeptidases / genetics
  • [MeSH-minor] Adenocarcinoma / pathology. Gene Deletion. Genetic Markers. Humans. Male. Prostatic Intraepithelial Neoplasia / pathology. Translocation, Genetic

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  • (PMID = 20736744.001).
  • [ISSN] 1533-4066
  • [Journal-full-title] Diagnostic molecular pathology : the American journal of surgical pathology, part B
  • [ISO-abbreviation] Diagn. Mol. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Genetic Markers; EC 3.4.21.- / Serine Endopeptidases; EC 3.4.21.- / TMPRSS2 protein, human
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7. Apgar BS, Kittendorf AL, Bettcher CM, Wong J, Kaufman AJ: Update on ASCCP consensus guidelines for abnormal cervical screening tests and cervical histology. Am Fam Physician; 2009 Jul 15;80(2):147-55
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  • Human papillomavirus testing is now included for management of atypical glandular cytology, for follow-up after treatment for cervical intraepithelial neoplasia, and in combination with cytologic screening in women 30 years and older.
  • Colposcopy is recommended for adult women with low-grade squamous intraepithelial lesion, atypical glandular cells, high-grade intraepithelial neoplasia, and atypical squamous cells-cannot exclude high-grade intraepithelial neoplasia.
  • Cervical intraepithelial neoplasia, grade 1 can be managed conservatively in adult women, but treatment for cervical intraepithelial neoplasia, grades 2 and 3 is recommended.
  • Immediate treatment is an option for adult women but not for adolescents with high-grade squamous intraepithelial lesion.
  • Conservative management of adolescents with any cytologic or histologic diagnosis except specified cervical intraepithelial neoplasia, grade 3 and adenocarcinoma in situ is recommended.
  • Colposcopy is preferred for pregnant women with low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion, but evaluation of the former may be deferred until no earlier than six weeks postpartum.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / diagnosis. Cervix Uteri / pathology. Precancerous Conditions / diagnosis. Uterine Cervical Neoplasms / diagnosis. Vaginal Smears


8. Gale N, Michaels L, Luzar B, Poljak M, Zidar N, Fischinger J, Cardesa A: Current review on squamous intraepithelial lesions of the larynx. Histopathology; 2009 May;54(6):639-56
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  • [Title] Current review on squamous intraepithelial lesions of the larynx.
  • Squamous intraepithelial lesions (SILs) of the larynx, clinically usually defined as leukoplakia and chronic laryngitis, have remained the main controversial topic in laryngeal pathology for decades as regards classification, histological diagnosis and treatment.
  • Three currently used classifications of SILs are reviewed here: the dysplasia system, the Ljubljana classification and the binary system of squamous intraepithelial neoplasia.
  • Transition from normal epithelium to SILs and squamous cell carcinoma is related to progressive accumulation of genetic changes leading to a clonal population of transformed epithelial cells.
  • [MeSH-major] Laryngeal Neoplasms / pathology. Larynx / pathology. Neoplasms, Squamous Cell / pathology

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  • (PMID = 18752537.001).
  • [ISSN] 1365-2559
  • [Journal-full-title] Histopathology
  • [ISO-abbreviation] Histopathology
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 189
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9. Offerhaus GJ: Grading gastrointestinal dysplasia and what to call it when you don't know what it is. J Pathol; 2007 Jun;212(2):121-3
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  • [Title] Grading gastrointestinal dysplasia and what to call it when you don't know what it is.
  • Dysplasia in the gastrointestinal tract is defined as intraepithelial neoplasia (IEN) according to the WHO nomenclature.
  • Invasive cancer is preceded by non-invasive precursor stages and the clonal epithelial cell proliferation in these pre-invasive stages is diagnosed as dysplasia or IEN.
  • Dysplasia is therefore a marker for cancer risk and guides surveillance.
  • Dysplasia is conventionally graded using a two-tier system and low- and high-grade dysplasia convey different connotations regarding cancer risk.
  • This perspective argues that the critical differential diagnosis is the one between neoplastic and non-neoplastic epithelial cell proliferations and the relevance of grading dysplasia is questionable.
  • [MeSH-major] Gastrointestinal Neoplasms / pathology
  • [MeSH-minor] Basement Membrane / pathology. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Epithelial Cells / pathology. Gastrointestinal Tract / pathology. Humans. Loss of Heterozygosity / genetics. Mutation. Neoplasm Invasiveness. Precancerous Conditions / pathology. Risk Assessment

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  • [Copyright] Copyright 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 17471451.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 10
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10. Cecena G, Wen F, Cardiff RD, Oshima RG: Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene. Am J Pathol; 2006 Jan;168(1):310-20
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  • [Title] Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene.
  • To determine how different epithelial cell types respond to the same oncogenic stimulation, we have used a modified human keratin 18 gene to conditionally express the polyomavirus middle T antigen (PyMT) oncogene in simple epithelial tissues of transgenic mice.
  • Activation of PyMT expression by transgenic Cre recombinase in mammary epithelial cells resulted in carcinomas in all bitransgenic females.
  • PyMT expression induced by K18-driven Cre in internal epithelial organs resulted in pancreatic acinar metaplasia and ductal dysplasia with remarkable desmoplastic stromal responses in all 25 bitransgenic mice.
  • Elevated PyMT RNA expression also correlated with intraepithelial neoplasia in the prostate.

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  • (PMID = 16400032.001).
  • [ISSN] 0002-9440
  • [Journal-full-title] The American journal of pathology
  • [ISO-abbreviation] Am. J. Pathol.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / R01 CA89140; United States / NCI NIH HHS / CA / R01 CA089140; United States / NCI NIH HHS / CA / CA30199; United States / NCI NIH HHS / CA / P30 CA030199; United States / NCRR NIH HHS / RR / U42 RR14905; United States / NCRR NIH HHS / RR / U42 RR014905; United States / NCI NIH HHS / CA / R01CA42302; United States / NCI NIH HHS / CA / P01 CA102583
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Polyomavirus Transforming; 0 / Basic Helix-Loop-Helix Transcription Factors; 0 / Hes1 protein, mouse; 0 / Homeodomain Proteins; 0 / KRT18 protein, human; 0 / Keratin-18; 0 / RNA, Messenger; 68238-35-7 / Keratins; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases
  • [Other-IDs] NLM/ PMC1592648
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11. Nobili C, Franciosi C, Degrate L, Caprotti R, Romano F, Perego E, Trezzi R, Leone BE, Uggeri F: A case of pancreatic heterotopy of duodenal wall, intraductal papillary mucinous tumor and intraepithelial neoplasm of pancreas, papillary carcinoma of kidney in a single patient. Tumori; 2006 Sep-Oct;92(5):455-8
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  • [Title] A case of pancreatic heterotopy of duodenal wall, intraductal papillary mucinous tumor and intraepithelial neoplasm of pancreas, papillary carcinoma of kidney in a single patient.
  • We report a case of the contemporaneous presence of two histologically different pancreatic neoplasms, one renal cancer and one embryogenic duodenal anomaly in a single patient.
  • Histopathologic analysis of the surgical specimen revealed mild differentiated papillary renal carcinoma, intraductal papillary mucinous adenoma of the pancreatic head, foci of intraepithelial pancreatic neoplasm and pancreatic heterotopy of duodenal muscular and submucosal layers.
  • [MeSH-major] Carcinoma, Pancreatic Ductal. Carcinoma, Papillary. Choristoma. Cystadenocarcinoma, Mucinous. Duodenal Diseases. Kidney Neoplasms. Neoplasms, Multiple Primary. Pancreas. Pancreatic Neoplasms


12. Howell-Jones R, Bailey A, Beddows S, Sargent A, de Silva N, Wilson G, Anton J, Nichols T, Soldan K, Kitchener H, Study Group Collaborators: Multi-site study of HPV type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in England. Br J Cancer; 2010 Jul 13;103(2):209-16
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multi-site study of HPV type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in England.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / virology. Cervix Uteri / virology. Papillomavirus Infections / epidemiology. Uterine Cervical Neoplasms / virology
  • [MeSH-minor] Adenocarcinoma / virology. Adult. Biopsy. England / epidemiology. Female. Human papillomavirus 16 / isolation & purification. Human papillomavirus 18 / isolation & purification. Humans. Middle Aged. Neoplasms, Squamous Cell / virology. Papillomavirus Vaccines. Prevalence


13. Seifi S, Shafaei SN, Nosrati K, Ariaeifar B: Lack of elevated HER2/neu expression in epithelial dysplasia and oral squamous cell carcinoma in Iran. Asian Pac J Cancer Prev; 2009 Oct-Dec;10(4):661-4
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  • [Title] Lack of elevated HER2/neu expression in epithelial dysplasia and oral squamous cell carcinoma in Iran.
  • MATERIALS AND METHODS: Expression of HER2/neu oncoprotein in OSCCs (N= 18), oral epithelial dysplasia (N= 18) and normal oral mucosa (N= 18) was assessed by immunohistochemistry using a cerbB2 antibody kit.
  • In oral epithelial dysplasia, 2/18 (11.1%) demonstrated staining, as did 3/18 OSCCs.
  • Membrane staining was observed in all cases and there was no significant variation in frequency/intensity between normal oral mucosa / oral epithelial dysplasia and OSCCs (p>0.05).
  • [MeSH-major] Carcinoma, Squamous Cell / metabolism. Mouth Mucosa / metabolism. Mouth Neoplasms / metabolism. Precancerous Conditions / metabolism. Receptor, ErbB-2 / metabolism
  • [MeSH-minor] Humans. Immunoenzyme Techniques. Iran. Neoplasm Staging. Prognosis. Retrospective Studies. Survival Rate. Up-Regulation


14. Goldstein NS: Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am J Clin Pathol; 2006 Jan;125(1):132-45
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  • [Title] Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases.
  • Eight sessile serrated adenoma (SSA), right colon polypectomies with focal invasive adenocarcinoma or high-grade dysplasia were studied to identify features indicating a high risk of transformation and characterize the morphologic features of serrated dysplasia; 6 cases had invasive adenocarcinoma; 2 were high-grade dysplasia.
  • In the 6 invasive adenocarcinomas, the neoplasm extended directly down into the submucosa without lateral intramucosal spread.
  • All 8 cases had high-grade serrated-type dysplasia.
  • Small proximal SSAs can transform into adenocarcinoma without a component of adenomatous dysplasia.
  • [MeSH-major] Adenocarcinoma / pathology. Adenoma / pathology. Chromosomal Instability. Colonic Neoplasms / pathology. Microsatellite Repeats

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  • (PMID = 16483002.001).
  • [ISSN] 0002-9173
  • [Journal-full-title] American journal of clinical pathology
  • [ISO-abbreviation] Am. J. Clin. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Adaptor Proteins, Signal Transducing; 0 / Carrier Proteins; 0 / MLH1 protein, human; 0 / Nuclear Proteins
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15. McCredie MR, Sharples KJ, Paul C, Baranyai J, Medley G, Jones RW, Skegg DC: Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol; 2008 May;9(5):425-34
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study.
  • BACKGROUND: The invasive potential of cervical intraepithelial neoplasia 3 (CIN3; also termed stage 0 carcinoma) has been poorly defined.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / pathology. Uterine Cervical Neoplasms / pathology. Vaginal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Biopsy. Cohort Studies. Colposcopy. Disease Progression. Female. Humans. Hysterectomy. Incidence. Kaplan-Meier Estimate. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Neoplasm, Residual. New Zealand / epidemiology. Proportional Hazards Models. Refusal to Treat. Retrospective Studies. Risk Assessment. Time Factors. Treatment Outcome. Vaginal Smears


16. Ortner MA, Fusco V, Ebert B, Sukowski U, Weber-Eibel J, Fleige B, Stolte M, Oberhuber G, Rinneberg H, Lochs H: Time-gated fluorescence spectroscopy improves endoscopic detection of low-grade dysplasia in ulcerative colitis. Gastrointest Endosc; 2010 Feb;71(2):312-8
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  • [Title] Time-gated fluorescence spectroscopy improves endoscopic detection of low-grade dysplasia in ulcerative colitis.
  • BACKGROUND: Dysplasia in ulcerative colitis is frequently missed with 4-quadrant biopsies.
  • OBJECTIVE: We compared detection of invisible flat intraepithelial neoplasia with protoporphyrin IX fluorescence and standard 4-quadrant biopsies.
  • MAIN OUTCOME MEASUREMENTS: The primary outcome criterion was detection rate of invisible flat intraepithelial neoplasia.
  • RESULTS: Invisible flat intraepithelial neoplasia was detected in 3 (7%) patients by white light 4-quadrant biopsies and in 10 (24%) patients by fluorescence-guided endoscopy (P = .02).
  • The sensitivity and specificity for differentiating patients with and without dysplasia were 100% and 81%, respectively.
  • CONCLUSION: The detection rate of intraepithelial neoplasia in patients with ulcerative colitis can be improved by fluorescence-guided colonoscopy.
  • [MeSH-major] Carcinoma in Situ / pathology. Colitis, Ulcerative / pathology. Colonoscopy / methods. Colorectal Neoplasms / pathology. Precancerous Conditions / pathology. Spectrometry, Fluorescence / methods


17. Soreide K, Buter TC, Janssen EA, Gudlaugsson E, Skaland I, Körner H, Baak JP: Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. Cell Oncol; 2007;29(4):301-13
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  • Influence of classic features (e.g., intraepithelial neoplasia grade, histological type, size) was examined.
  • [MeSH-major] Adenoma / pathology. Apoptosis Regulatory Proteins / metabolism. Cell Cycle Proteins / metabolism. Colorectal Neoplasms / pathology. Neoplasms, Second Primary / pathology
  • [MeSH-minor] Adult. Aged. Biomarkers, Tumor / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / metabolism. Cyclin-Dependent Kinase Inhibitor p21 / metabolism. Demography. Female. Humans. Immunohistochemistry. Inhibitor of Apoptosis Proteins. Kaplan-Meier Estimate. Male. Microtubule-Associated Proteins / metabolism. Middle Aged. Multivariate Analysis. Neoplasm Proteins / metabolism. Proportional Hazards Models. Telomerase / metabolism. beta Catenin / metabolism

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  • (PMID = 17641414.001).
  • [ISSN] 1570-5870
  • [Journal-full-title] Cellular oncology : the official journal of the International Society for Cellular Oncology
  • [ISO-abbreviation] Cell. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Apoptosis Regulatory Proteins; 0 / BIRC5 protein, human; 0 / Biomarkers, Tumor; 0 / Cell Cycle Proteins; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Cyclin-Dependent Kinase Inhibitor p21; 0 / Inhibitor of Apoptosis Proteins; 0 / Microtubule-Associated Proteins; 0 / Neoplasm Proteins; 0 / beta Catenin; EC 2.7.7.49 / TERT protein, human; EC 2.7.7.49 / Telomerase
  • [Other-IDs] NLM/ PMC4617994
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18. Mou YP, Xu XW, Xie K, Zhou W, Zhou YC, Chen K: Laparoscopic wedge resection of synchronous gastric intraepithelial neoplasia and stromal tumor: a case report. World J Gastroenterol; 2010 Oct 21;16(39):5005-8
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  • [Title] Laparoscopic wedge resection of synchronous gastric intraepithelial neoplasia and stromal tumor: a case report.
  • Synchronous occurrence of epithelial neoplasia and gastrointestinal stromal tumor (GIST) in the stomach is uncommon.
  • We present here a 60-year-old female case of synchronous occurrence of gastric high-level intraepithelial neoplasia and GIST with the features of 22 similar cases and detailed information reported in the English-language literature summarized.
  • In the present patient, epithelial neoplasia and GIST were removed en bloc by laparoscopic wedge resection.
  • [MeSH-major] Carcinoma in Situ / surgery. Gastrointestinal Stromal Tumors / surgery. Laparoscopy. Neoplasms, Multiple Primary. Stomach Neoplasms / surgery
  • [MeSH-minor] Female. Gastroscopy. Humans. Middle Aged. Neoplasm Staging. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 20954290.001).
  • [ISSN] 2219-2840
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Other-IDs] NLM/ PMC2957612
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19. Hosni ES, Salum FG, Cherubini K, Yurgel LS, Figueiredo MA: Oral erythroplakia and speckled leukoplakia: retrospective analysis of 13 cases. Braz J Otorhinolaryngol; 2009 Mar-Apr;75(2):295-9
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  • The lesions showed epithelial dysplasia, where more than 50% were diagnosed as in situ or invasive carcinoma.
  • CONCLUSIONS: Despite low prevalence, oral homogeneous erythroplakia and speckled leukoplakia show Histopathological alterations vary from epithelial dysplasia to invasive carcinoma.


20. Hillemanns P, Wang X, Staehle S, Michels W, Dannecker C: Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy. Gynecol Oncol; 2006 Feb;100(2):271-5
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  • [Title] Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy.
  • OBJECTIVES: To evaluate various treatment modalities for vulvar intraepithelial neoplasia (VIN) in relation to possible risk factors for recurrence.
  • The risk for recurrence significantly increased with VIN grade (P = 0.02), multifocal VIN disease (P = 0.01), multicentric intraepithelial neoplasia (P = 0.05) and high-risk HPV infection (P < 0.001).
  • [MeSH-major] Carcinoma in Situ / drug therapy. Carcinoma in Situ / surgery. Vulvar Neoplasms / drug therapy. Vulvar Neoplasms / surgery
  • [MeSH-minor] Adult. Aminolevulinic Acid / therapeutic use. Female. Gynecologic Surgical Procedures / methods. Humans. Laser Therapy / methods. Middle Aged. Neoplasm Recurrence, Local. Papillomaviridae. Papillomavirus Infections / complications. Photochemotherapy. Photosensitizing Agents / therapeutic use. Retrospective Studies. Risk Factors. Treatment Outcome

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  • (PMID = 16169064.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 88755TAZ87 / Aminolevulinic Acid
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21. Folker MB, Bernstein IT, Holck S: [Serrated, hyperplastic and hyperplasia-like colorectal polyps]. Ugeskr Laeger; 2006 Nov 13;168(46):4005-9
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  • Since epithelial dysplasia is an integrated component of mixed hyperplastic/adenomatous polyp and of the serrated adenoma, such a diagnosis would dictate control colonoscopy comparable to the guidelines for subjects with conventional adenomas.
  • [MeSH-major] Adenoma / pathology. Colonic Polyps / pathology. Colorectal Neoplasms / pathology

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  • (PMID = 17125655.001).
  • [ISSN] 1603-6824
  • [Journal-full-title] Ugeskrift for laeger
  • [ISO-abbreviation] Ugeskr. Laeg.
  • [Language] dan
  • [Publication-type] Comparative Study; English Abstract; Journal Article; Review
  • [Publication-country] Denmark
  • [Number-of-references] 40
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22. Fléjou JF: Barrett's oesophagus: from metaplasia to dysplasia and cancer. Gut; 2005 Mar;54 Suppl 1:i6-12
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  • [Title] Barrett's oesophagus: from metaplasia to dysplasia and cancer.
  • On morphology, the carcinogenetic process of Barrett's mucosa progresses through increasing grades of epithelial dysplasia.
  • Dysplasia, a synonym of intraepithelial neoplasia, is the only marker that can be used at the present time to delineate a population of patients at high risk of cancer.
  • [MeSH-major] Barrett Esophagus / pathology. Esophageal Neoplasms / pathology. Precancerous Conditions / pathology
  • [MeSH-minor] Aneuploidy. Cell Transformation, Neoplastic / pathology. DNA, Neoplasm / analysis. Esophagus / pathology. Genes, p53 / genetics. Humans. Immunohistochemistry / methods. Mucins / analysis. Mucous Membrane / pathology. Neoplasms, Glandular and Epithelial / classification. Neoplasms, Glandular and Epithelial / pathology. Risk Factors

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  • (PMID = 15711008.001).
  • [ISSN] 0017-5749
  • [Journal-full-title] Gut
  • [ISO-abbreviation] Gut
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / DNA, Neoplasm; 0 / Mucins
  • [Number-of-references] 66
  • [Other-IDs] NLM/ PMC1867794
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23. López-Morales D, Velázquez-Márquez N, Valenzuela O, Santos-López G, Reyes-Leyva J, Vallejo-Ruiz V: Enhanced sialyltransferases transcription in cervical intraepithelial neoplasia. Invest Clin; 2009 Mar;50(1):45-53
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  • [Title] Enhanced sialyltransferases transcription in cervical intraepithelial neoplasia.
  • A study of the sialic acid concentration in local tissue of cervix and in serum showed a slight elevation in benign inflammatory lesions and a moderate elevation in severe neoplasia, but to date, altered expression of STs in cervical intraepithelial neoplasia has not yet been evaluated.
  • This study investigates the changes in mRNA expression of three STs (ST6Gal I, ST3Gal III, and ST3Gal IV) in cervical intraepithelial lesions (CIN).
  • [MeSH-major] Cervical Intraepithelial Neoplasia / enzymology. Neoplasm Proteins / genetics. RNA, Messenger / biosynthesis. RNA, Neoplasm / biosynthesis. Sialyltransferases / genetics. Uterine Cervical Neoplasms / enzymology

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  • (PMID = 19418726.001).
  • [ISSN] 0535-5133
  • [Journal-full-title] Investigación clínica
  • [ISO-abbreviation] Invest Clin
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Venezuela
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / RNA, Messenger; 0 / RNA, Neoplasm; EC 2.4.99.- / Sialyltransferases; GZP2782OP0 / N-Acetylneuraminic Acid
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24. Gagne SE, Jensen R, Polvi A, Da Costa M, Ginzinger D, Efird JT, Holly EA, Darragh T, Palefsky JM: High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia. J Acquir Immune Defic Syndr; 2005 Oct 1;40(2):182-9
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  • [Title] High-resolution analysis of genomic alterations and human papillomavirus integration in anal intraepithelial neoplasia.
  • Anal intraepithelial neoplasia (AIN) is the likely precursor to anal cancer.
  • AIN is associated with human papillomavirus (HPV) infection, and HPV-associated genomic instability may play an important role in the progression of squamous intraepithelial neoplasia to cancer.
  • [MeSH-major] Anus Neoplasms / virology. Carcinoma in Situ / virology. Genome, Viral. Papillomaviridae / physiology. Virus Integration

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  • (PMID = 16186736.001).
  • [ISSN] 1525-4135
  • [Journal-full-title] Journal of acquired immune deficiency syndromes (1999)
  • [ISO-abbreviation] J. Acquir. Immune Defic. Syndr.
  • [Language] eng
  • [Grant] United States / NCRR NIH HHS / RR / 5 M01-RR-00079; United States / NCI NIH HHS / CA / R01CA54053; United States / NCI NIH HHS / CA / U01 CA66529; United States / NCI NIH HHS / CA / U01 CA70019
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
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25. Hurlstone DP, Sanders DS, Lobo AJ, McAlindon ME, Cross SS: Indigo carmine-assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation. Endoscopy; 2005 Dec;37(12):1186-92
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  • [Title] Indigo carmine-assisted high-magnification chromoscopic colonoscopy for the detection and characterisation of intraepithelial neoplasia in ulcerative colitis: a prospective evaluation.
  • BACKGROUND AND STUDY AIMS: Recent data suggest that panchromoscopy using methylene blue can improve the detection of intraepithelial neoplastic lesions in the context of surveillance colonoscopy for patients with chronic ulcerative colitis.
  • We hypothesised that targeted chromoscopy alone, with high-magnification imaging, may increase the total number of intraepithelial neoplastic lesions detected, compared with conventional colonoscopy and biopsy surveillance according to current protocols.
  • RESULTS: Significantly more intraepithelial neoplastic lesions were detected in the magnification chromoscopy group compared with controls (69 vs. 24, P<0.0001).
  • Intraepithelial neoplasia was observed in 67 lesions, of which 53 (79%) were detected using magnification chromoscopy alone.
  • Chromoscopy increased the number of flat lesions with intraepithelial neoplasia detected compared with controls (P<0.001).
  • Twenty intraepithelial neoplastic lesions were detected from 12,850 non-targeted biopsies in the HMCC group (0.16%), while 49 intraepithelial neoplastic lesions were detected from the 644 targeted biopsies in the HMCC group (8%).
  • From 12,482 non-targeted biopsies taken in the control group patients, 18 (0.14%) showed intraepithelial neoplasia.
  • The yield of intraepithelial neoplastic lesions from targeted biopsies in the control group (i. e. without HMCC imaging), however, was only modestly improved at 1.6% (6/369).
  • CONCLUSIONS: Magnification chromoscopy improves the detection of intraepithelial neoplasia in the endoscopic screening of patients with chronic ulcerative colitis.
  • [MeSH-major] Carcinoma in Situ / diagnosis. Colitis, Ulcerative / diagnosis. Colonic Neoplasms / diagnosis. Colonoscopy / methods. Image Enhancement / methods. Indigo Carmine


26. Xu HX, Xie XY, Lu MD, Liu GJ, Xu ZF, Liang JY, Chen LD: Unusual benign focal liver lesions: findings on real-time contrast-enhanced sonography. J Ultrasound Med; 2008 Feb;27(2):243-54
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  • The pathologic examinations proved that they were intrahepatic biliary cystadenoma (n = 1), angiomyolipoma (AML; n = 4), lipoma (n = 1), biliary epithelial dysplasia (n = 1), a fungal inflammatory mass (n = 1), tuberculoma (n = 2), an inflammatory pseudotumor (n = 7), sarcoidosis (n = 1), solitary necrotic nodules (n = 2), peliosis hepatis (n = 2), and focal fibrosis after surgery (n = 4).
  • On the other hand, for those lesions showing hyperenhancement, isoenhancement, or hypoenhancement during the arterial phase and hypoenhancement during the late phase, including intrahepatic biliary cystadenoma, biliary epithelial dysplasia, infected liver diseases, the inflammatory pseudotumor, sarcoidosis, and peliosis hepatis, the differential diagnosis between benignity and malignancy was difficult, and pathologic tests were mandatory.

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  • (PMID = 18204015.001).
  • [ISSN] 0278-4297
  • [Journal-full-title] Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • [ISO-abbreviation] J Ultrasound Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media
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27. Sasaki M, Yamaguchi J, Itatsu K, Ikeda H, Nakanuma Y: Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis. J Pathol; 2008 Jun;215(2):175-83
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  • Neoplastic biliary lesions were classified into biliary intraepithelial neoplasm (BilIN-1, 2 and 3) and invasive carcinoma.
  • We selected 15 foci of invasive carcinoma, 8 BilIN-3 (carcinoma in situ), 12 BilIN-2 (high-grade dysplasia), 32 BilIN-1 (low-grade dysplasia) and 37 non-neoplastic biliary epithelia from these livers.
  • Our data suggest that over-expression of EZH2 may induce hypermethylation of p16 INK4a promoter followed by decreased expression of p16 INK4a in the multi-step cholangiocarcinogenesis through intraepithelial neoplasm in hepatolithiasis.
  • [MeSH-major] Bile Duct Neoplasms / metabolism. Cholangiocarcinoma / metabolism. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA-Binding Proteins / genetics. Gene Expression Regulation, Neoplastic. Transcription Factors / genetics

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  • [Copyright] Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
  • (PMID = 18393368.001).
  • [ISSN] 0022-3417
  • [Journal-full-title] The Journal of pathology
  • [ISO-abbreviation] J. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / BMI1 protein, human; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins; 0 / RNA, Small Interfering; 0 / Repressor Proteins; 0 / Transcription Factors; EC 2.1.1.43 / EZH2 protein, human; EC 2.1.1.43 / Polycomb Repressive Complex 2; EC 6.3.2.19 / Polycomb Repressive Complex 1
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28. Hansmann J, Grenacher L: [Radiological imaging of the upper gastrointestinal tract. Part 1. The esophagus]. Radiologe; 2006 Dec;46(12):1077-87; quiz 1088
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  • The diagnosis of gastroesophageal reflux disease should be made by barium studies, but discrete inflammation as well as epithelial dysplasia are best investigated by classic endoscopy and modern endoscopic techniques.
  • [MeSH-major] Esophageal Diseases / diagnosis. Esophageal Neoplasms / diagnosis. Magnetic Resonance Imaging. Tomography, X-Ray Computed
  • [MeSH-minor] Deglutition Disorders / etiology. Diagnosis, Differential. Diverticulum, Esophageal / diagnosis. Esophagoscopy. Esophagus / pathology. Humans. Neoplasm Invasiveness. Neoplasm Staging. Sensitivity and Specificity


29. Li Z, Yu T, Zuo XL, Gu XM, Zhou CJ, Ji R, Li CQ, Wang P, Zhang TG, Ho KY, Li YQ: Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: a feasibility study. Gastrointest Endosc; 2010 Dec;72(6):1146-53
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  • [Title] Confocal laser endomicroscopy for in vivo diagnosis of gastric intraepithelial neoplasia: a feasibility study.
  • Several studies have reported that this technique is of value in the diagnosis of premalignant lesions in the GI tract, but as yet no investigations have reported its application in the analysis of gastric intraepithelial neoplasia (GIN).
  • MAIN OUTCOME MEASUREMENTS: Sensitivity, specificity, and positive and negative likelihood ratios of CLE diagnosis of biopsy-proven intraepithelial neoplasia by per-lesion analysis.
  • Intraepithelial neoplasia score ≥5 differentiated high-grade from low-grade intraepithelial neoplasia with a sensitivity of 66.7% and a specificity of 88.0%.
  • [MeSH-major] Carcinoma in Situ / pathology. Gastroscopy. Microscopy, Confocal. Stomach Neoplasms / pathology

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  • [Copyright] Copyright © 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
  • (PMID = 21111868.001).
  • [ISSN] 1097-6779
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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30. Jeong CW, Lee JH, Sohn SS, Ryu SW, Kim DK: Mitochondrial microsatellite instability in gastric cancer and gastric epithelial dysplasia as a precancerous lesion. Cancer Epidemiol; 2010 Jun;34(3):323-7
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  • [Title] Mitochondrial microsatellite instability in gastric cancer and gastric epithelial dysplasia as a precancerous lesion.
  • To clarify the role of genetic instability in the progression from gastric dysplasia to gastric cancer, mitochondrial microsatellite instability (mtMSI) was studied in gastric cancer and gastric dysplasia.
  • METHODS: DNA was isolated from paired normal and tumoral tissues in 24 patients with gastric dysplasia (low grade) and 49 patients with gastric cancer. mtMSI was analyzed using eight microsatellite markers. mtMSI in gastric dysplasia was studied prospectively to elucidate the relation between mtMSI and gastric carcinogenesis.
  • In gastric dysplasia, mtMSI was detected in 3 (12.5%) of 24 patients with gastric dysplasia. mtMSI-positive gastric dysplasia showed a poor prognosis statistically compared to mtMSI negative through progression to high-grade dysplasia or gastric cancer.
  • [MeSH-major] DNA, Mitochondrial / chemistry. Gastric Mucosa / pathology. Microsatellite Instability. Precancerous Conditions / genetics. Stomach Neoplasms / genetics

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  • [Copyright] Copyright (c) 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20409774.001).
  • [ISSN] 1877-783X
  • [Journal-full-title] Cancer epidemiology
  • [ISO-abbreviation] Cancer Epidemiol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / DNA, Mitochondrial
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31. Emerson LL, Carney HM, Layfield LJ, Sherbotie JR: Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study. Pediatr Transplant; 2008 Aug;12(5):600-5
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  • A renal neoplasm developing in the adult donor kidney of a pediatric transplant recipient has only rarely been reported.
  • Our case is the second report of neoplasia occurring in association with BK virus nephropathy post-transplantation, suggesting that BK virus may play a role in oncogenesis.
  • In our study, immunohistochemical staining with antibody directed against BK virus large T antigen showed nuclear staining within urothelium, tubular epithelium, tubular intraepithelial neoplasia, and invasive carcinoma.
  • The finding of T-Ag protein expression in both intraepithelial and invasive neoplastic tissues in our case raises the possibility of BK virus as a causative agent in oncogenesis.
  • [MeSH-major] BK Virus / genetics. Carcinoma / virology. Kidney Diseases / virology. Kidney Neoplasms / virology. Kidney Tubules, Collecting / pathology
  • [MeSH-minor] Child. Humans. Immunohistochemistry / methods. In Situ Hybridization. Kidney Transplantation / adverse effects. Kidney Transplantation / methods. Male. Neoplasm Invasiveness. Postoperative Period


32. Pankova OV, Perel'muter VM, Cheremisina OV: [A relationship of squamous-cell metaplasia with the pattern of the course of a respiratory epithelial dysplastic process]. Klin Lab Diagn; 2008 Apr;(4):46-8
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  • [Title] [A relationship of squamous-cell metaplasia with the pattern of the course of a respiratory epithelial dysplastic process].
  • A follow-up of the patients indicated that in the group of patients with epithelial dysplasia without squamous-cell metaplasia, the prognosis was good in 65.6% of cases.
  • In the group of patients with epithelial dysplasia and squamous-cell metaplasia, the prognosis was poor in 86.2% of cases.

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  • (PMID = 18619206.001).
  • [ISSN] 0869-2084
  • [Journal-full-title] Klinicheskaia laboratornaia diagnostika
  • [ISO-abbreviation] Klin. Lab. Diagn.
  • [Language] rus
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
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33. Roa I, de Aretxabala X, Araya JC, Roa J: Preneoplastic lesions in gallbladder cancer. J Surg Oncol; 2006 Jun 15;93(8):615-23
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  • The knowledge regarding the etiology and mechanisms through which this neoplasia is developed is significantly less compared to other malignant tumors.
  • RESULTS: The epithelial lesions involved in gallbladder carcinogenesis are dysplasia and adenomas that represent two biologically distinct carcinogenetic models.
  • Dysplasia progresses to carcinoma in situ (CIS) and subsequently becomes invasive.
  • Over 80% of invasive gallbladder cancers present areas adjacent to the CIS and epithelial dysplasia.
  • Epithelial dysplasia which is not associated with gallbladder cancer is observed in approximately 1% of cholecystectomies for symptomatic lithiasis.
  • Metaplasia, dysplasia, and CIS are present in the mucosa adjacent to the cancer in 66%, 81.3%, and 69%, respectively.
  • The average ages of patients with dysplasia not associated to cancer (51.9 years), early carcinomas (56.8 years), and advanced carcinomas (62.9 years) demonstrate a gradient which suggests the progression of these lesions.
  • CONCLUSIONS: From the morphological point of view, the dysplasia-carcinoma sequence is the most plausible carcinogenic pathway for gallbladder cancer, a process which would require a period of approximately 10 years.
  • [MeSH-major] Adenoma / pathology. Carcinoma in Situ / pathology. Gallbladder / pathology. Gallbladder Neoplasms / pathology. Precancerous Conditions / pathology

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  • [Copyright] Copyright 2006 Wiley-Liss, Inc.
  • (PMID = 16724345.001).
  • [ISSN] 0022-4790
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] United States
  • [Number-of-references] 86
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34. Darvin VV, Funygin DV: [Endoscopic chromoscopy in diagnosing and treatment of complicated gastroesophageal reflux disease]. Vestn Khir Im I I Grek; 2008;167(4):30-1
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  • Inclusion of chromoendoscopy in the program of examination and treatment of patients with gastroesophageal reflux disease allowed higher detection of severe epithelial dysplasia (to 10.3%), leukoplakia (to 62.1%) and esophagus cancer (to 3.5%) and improvement of the results of endoscopic treatment.
  • [MeSH-major] Electrocoagulation / methods. Endoscopy, Gastrointestinal / methods. Esophageal Neoplasms / diagnosis. Esophagus / pathology. Gastroesophageal Reflux / diagnosis. Iodides. Leukoplakia / diagnosis

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  • (PMID = 18942432.001).
  • [ISSN] 0042-4625
  • [Journal-full-title] Vestnik khirurgii imeni I. I. Grekova
  • [ISO-abbreviation] Vestn. Khir. Im. I. I. Grek.
  • [Language] rus
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Russia (Federation)
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Iodides; T66M6Y3KSA / Lugol's solution
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35. Arens C, Glanz H, Wönckhaus J, Hersemeyer K, Kraft M: Histologic assessment of epithelial thickness in early laryngeal cancer or precursor lesions and its impact on endoscopic imaging. Eur Arch Otorhinolaryngol; 2007 Jun;264(6):645-9
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  • [Title] Histologic assessment of epithelial thickness in early laryngeal cancer or precursor lesions and its impact on endoscopic imaging.
  • The objective of the study was to assess the epithelial thickness in different lesions of the vocal folds in order to gain more information about its influence on endoscopic imaging.
  • Morphometric measurement of epithelial thickness was performed using a normal white light and an autofluorescence microscope.
  • The vocal fold mucosa revealed a progressive thickening from normal epithelium (NE = 147 microm) over the different grades of epithelial dysplasia (EDI = 258 microm, EDII = 301 microm, CIS = 445 microm) to early invasive carcinoma (EIC = 974 microm), while benign lesions presented only a slight epithelial thickening of an additional 100 microm.
  • In such a manner, moderate dysplasia showed a double increase, carcinoma in situ a triple increase and early invasive carcinoma even a sixfold increase of the mean epithelial thickness compared to normal laryngeal mucosa.
  • As fluorescence inducing light has a penetration depth of approximately 300 microm, a marked loss of autofluorescence was recognized from moderate dysplasia onwards, while mild dysplasia simply revealed a slight loss of fluorescence.
  • Autofluorescence microscopy demonstrated a threefold higher fluorescence intensity of the submucosal connective tissue compared to the epithelium, which showed always the same weak intensity independent of the grade of dysplasia.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Laryngeal Neoplasms / pathology. Laryngoscopy / methods. Precancerous Conditions / pathology. Vocal Cords / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Fluorescence. Humans. Male. Microscopy, Fluorescence. Middle Aged. Neoplasm Invasiveness. Retrospective Studies

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  • [ISSN] 0937-4477
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36. Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, Pearce HL, Reid BJ, Szabo E, Jordan VC, Spitz MR, Mills GB, Papadimitrakopoulou VA, Lotan R, Aggarwal BB, Bresalier RS, Kim J, Arun B, Lu KH, Thomas ME, Rhodes HE, Brewer MA, Follen M, Shin DM, Parnes HL, Siegfried JM, Evans AA, Blot WJ, Chow WH, Blount PL, Maley CC, Wang KK, Lam S, Lee JJ, Dubinett SM, Engstrom PF, Meyskens FL Jr, O'Shaughnessy J, Hawk ET, Levin B, Nelson WG, Hong WK, AACR Task Force on Cancer Prevention: Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clin Cancer Res; 2006 Jun 15;12(12):3661-97
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  • [Title] Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward.
  • This article reviews progress in chemopreventive drug development, especially data and concepts that are new since the 2002 AACR report on treatment and prevention of intraepithelial neoplasia.
  • Molecular biomarker expressions involved in mechanisms of carcinogenesis and genetic progression models of intraepithelial neoplasia are discussed and analyzed for how they can inform mechanism-based, molecularly targeted drug development as well as risk stratification, cohort selection, and end-point selection for clinical trials.
  • We outline the concept of augmenting the risk, mechanistic, and disease data from histopathologic intraepithelial neoplasia assessments with molecular biomarker data.
  • [MeSH-major] Biomarkers, Tumor / analysis. Neoplasms, Glandular and Epithelial / prevention & control
  • [MeSH-minor] Breast Neoplasms / prevention & control. Chemoprevention. Colorectal Neoplasms / prevention & control. Disease Progression. Female. Humans. Infection. Inflammation. Male. Monitoring, Physiologic. Signal Transduction

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  • (PMID = 16778094.001).
  • [ISSN] 1078-0432
  • [Journal-full-title] Clinical cancer research : an official journal of the American Association for Cancer Research
  • [ISO-abbreviation] Clin. Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 410
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37. Jansen SA, Conzen SD, Fan X, Markiewicz EJ, Newstead GM, Karczmar GS: Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study. Breast Cancer Res; 2009;11(5):R65
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  • [Title] Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.
  • The purpose of this study was to use magnetic resonance (MR) imaging to track in vivo the transition from in situ neoplasia to invasive cancer in a transgenic mouse model of human cancer.
  • METHODS: MR images of 12 female C3(1) SV40 Tag mice that develop mammary intraepithelial neoplasia (MIN) were obtained.
  • CONCLUSIONS: To our knowledge, the results reported here are the first measurements of the timescale and characteristics of progression from in situ neoplasia to invasive carcinoma and provide image-based evidence that DCIS may be a non-obligate precursor lesion with highly variable outcomes.
  • In addition, this study represents a first step towards developing methods of image acquisition for identifying radiological characteristics that might predict which in situ neoplasias will become invasive cancers and which are unlikely to progress.

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  • (PMID = 19732414.001).
  • [ISSN] 1465-542X
  • [Journal-full-title] Breast cancer research : BCR
  • [ISO-abbreviation] Breast Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA125183-01; United States / NCI NIH HHS / CA / R33 CA100996-02
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antigens, Polyomavirus Transforming
  • [Other-IDs] NLM/ PMC2790840
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38. Ananthanarayanan V, Deaton RJ, Yang XJ, Pins MR, Gann PH: Alteration of proliferation and apoptotic markers in normal and premalignant tissue associated with prostate cancer. BMC Cancer; 2006 Mar 17;6:73
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  • We evaluated the following markers: Ki67, Minichromosome Maintenance Protein-2 (Mcm-2), activated caspase-3 (a-casp3) and Bcl-2 to determine if they showed differential expression across progressive degrees of intraepithelial neoplasia and cancer in the prostate.
  • Tissue compartments representing normal, low grade prostatic intraepithelial neoplasia (LGPIN), high grade prostatic intraepithelial neoplasia (HGPIN), as well as different grades of cancer were mapped on H&E slides and adjacent sections were analyzed using immunohistochemistry.
  • Randomly selected nuclei and 40 x fields were scored by a single observer; basal and luminal epithelial layers were scored separately.

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  • (PMID = 16545117.001).
  • [ISSN] 1471-2407
  • [Journal-full-title] BMC cancer
  • [ISO-abbreviation] BMC Cancer
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA090386; United States / NCI NIH HHS / CA / R01 CA090759; United States / NCI NIH HHS / CA / P50 CA 90386; United States / NCI NIH HHS / CA / R01 CA 90759
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Cell Cycle Proteins; 0 / Ki-67 Antigen; 0 / Neoplasm Proteins; 0 / Nuclear Proteins; 0 / Proto-Oncogene Proteins c-bcl-2; EC 3.4.22.- / CASP3 protein, human; EC 3.4.22.- / Caspase 3; EC 3.4.22.- / Caspases; EC 3.6.4.12 / MCM2 protein, human; EC 3.6.4.12 / Minichromosome Maintenance Complex Component 2
  • [Other-IDs] NLM/ PMC1448200
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39. Leão JC, Duarte A, Gueiros LA, Carvalho AA, Barrett AW, Scully C, Porter S: Severe oral epithelial dysplasia in a patient receiving adalimumab therapy. J Oral Pathol Med; 2005 Aug;34(7):447-8
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  • [Title] Severe oral epithelial dysplasia in a patient receiving adalimumab therapy.

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  • [CommentOn] J Oral Pathol Med. 2005 Jan;34(1):53-5 [15610407.001]
  • (PMID = 16011616.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Comment; Letter
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Tumor Necrosis Factor-alpha; FYS6T7F842 / Adalimumab
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40. Liu J, Song XH, Wang QX: [Clinical significance of atypical squamous cells and low grade squamous intraepithelial lesions in cervical smear]. Zhonghua Yi Xue Za Zhi; 2007 Jul 3;87(25):1764-6
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  • [Title] [Clinical significance of atypical squamous cells and low grade squamous intraepithelial lesions in cervical smear].
  • OBJECTIVE: To investigate the clinical significance of atypical squamous cells (ASCUS) and low-grade squamous intraepithelial lesions (LSIL).
  • (1) Among the 405 patients with ASCUS, the percentage with chronic cervicitis was 57.04%, LSIL was 34.81%, HSIL was 3.95%, otherwise 2 cases (0.49%) of microinvasive cervical cancer and 15 cases (3.70%) of vulvar intraepithelial neoplasia (VIN) were found respectively.
  • CONCLUSION: ASCUS and LSIL does not represent a single biologic entity; it subsumes changes that are unrelated to neoplasia as well as findings that suggest the possible presence of underlying Cervical intraepithelial neoplasia (CIN) and rarely carcinoma.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / pathology. Neoplasms, Squamous Cell / pathology. Uterine Cervical Neoplasms / pathology


41. Eriksson NK, Färkkilä MA, Voutilainen ME, Arkkila PE: The clinical value of taking routine biopsies from the incisura angularis during gastroscopy. Endoscopy; 2005 Jun;37(6):532-6
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  • Dysplasia (intraepithelial neoplasia) was not found in any of the biopsied sites in any of the 272 patients. H. pylori was found in 39 of the 272 patients (14 %).

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  • (PMID = 15933925.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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42. von Knebel Doeberitz M, Reuschenbach M: [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus]. Hautarzt; 2010 Jan;61(1):13-20
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  • [Title] [Human papillomaviruses in the pathogenesis of intraepithelial neoplasia (AIN) and carcinoma of the anus].
  • [MeSH-major] Anus Neoplasms / virology. Biomarkers, Tumor / analysis. Carcinoma in Situ / physiopathology. Papillomavirus Infections / diagnosis. Papillomavirus Infections / virology. Precancerous Conditions / virology

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  • (PMID = 20033115.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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43. Barbagli G, Palminteri E, Mirri F, Guazzoni G, Turini D, Lazzeri M: Penile carcinoma in patients with genital lichen sclerosus: a multicenter survey. J Urol; 2006 Apr;175(4):1359-63
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  • All cases of histologically proven epithelial malignancy, namely SCC, VC and EQ, were reviewed to confirm the presence of neoplastic changes and ascertain the degree of SCC differentiation.
  • In 6 of 11 patients (55%) the histological study showed the presence of epithelial dysplasia.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Carcinoma, Squamous Cell / pathology. Carcinoma, Verrucous / complications. Carcinoma, Verrucous / pathology. Lichen Sclerosus et Atrophicus / complications. Lichen Sclerosus et Atrophicus / pathology. Penile Diseases / complications. Penile Neoplasms / complications

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  • (PMID = 16515998.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study
  • [Publication-country] United States
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44. Fontes A, de Sousa SM, dos Santos E, Martins MT: The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis. J Cutan Pathol; 2009 Nov;36(11):1151-6
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  • [Title] The severity of epithelial dysplasia is associated with loss of maspin expression in actinic cheilitis.
  • METHODS: Sections from 36 cases diagnosed as AC (18 cases with mild epithelial dysplasia, 11 with moderate and 7 with severe), 18 cases diagnosed as lip SCC and 7 specimens containing normal lip vermillion epithelium were submitted for immunohistochemical analysis to detect maspin.
  • RESULTS: All AC cases with mild and two cases with moderate dysplasia were scored 3.
  • The remaining nine cases with moderate dysplasia were identified as score 2, whereas all cases with severe dysplasia were scored 1.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / metabolism. Lip Neoplasms / metabolism. Precancerous Conditions / metabolism. Serpins / biosynthesis

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  • (PMID = 19222699.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / SERPIN-B5; 0 / Serpins
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45. Baudet JS, Castro V, Díaz-Bethencourt D, Morales S, Avilés J: [Bowenoide papulosis. An anal intraepithelial neoplasia]. Rev Esp Enferm Dig; 2009 Jun;101(6):440-1
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  • [Title] [Bowenoide papulosis. An anal intraepithelial neoplasia].
  • [Transliterated title] Papulomatosis bowenoide. Una neoplasia intraepitelial anal.
  • [MeSH-major] Anus Neoplasms / pathology. Carcinoma in Situ / pathology

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  • (PMID = 19630470.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Spain
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46. Lazăr D, Tăban S, Ardeleanu C, Simionescu C, Sporea I, Cornianu M, Vernic C: Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. Rom J Morphol Embryol; 2008;49(3):371-9
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  • RESULTS: The COX-2 immunoreactions have been significantly more frequent noticed in the gastric carcinomas included in the study (57.4%) and in the epithelial dysplasia areas adjacent to the carcinomas of intestinal type (35.5% of the cases), than in the normal peritumoral mucosa (4.9%) (p<0.001 ES).
  • [MeSH-major] Carcinoma / metabolism. Cyclooxygenase 2 / metabolism. Neovascularization, Pathologic / mortality. Stomach Neoplasms / metabolism

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  • (PMID = 18758643.001).
  • [ISSN] 1220-0522
  • [Journal-full-title] Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • [ISO-abbreviation] Rom J Morphol Embryol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Romania
  • [Chemical-registry-number] 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; EC 1.14.99.1 / Cyclooxygenase 2; EC 1.14.99.1 / PTGS2 protein, human
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47. Ogbureke KU, Abdelsayed RA, Kushner H, Li L, Fisher LW: Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma. Cancer; 2010 Apr 1;116(7):1709-17
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  • [Title] Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma.
  • RESULTS: : The OPL patient population was representative of previous studies with 20% progressing to OSCC, and no correlation between degree of dysplasia and progression.

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  • (PMID = 20186700.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / DE017791-05; United States / NIDCR NIH HHS / DE / K23 DE017791-05; United States / NIDCR NIH HHS / DE / K23DE017791-01A1; United States / Intramural NIH HHS / / ; United States / NIDCR NIH HHS / DE / K23 DE017791; United States / NIDCR NIH HHS / DE / K23 DE017791-01A1; United States / NIDCR NIH HHS / DE / DE017791-01A1
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Extracellular Matrix Proteins; 0 / IBSP protein, human; 0 / Integrin-Binding Sialoprotein; 0 / Phosphoproteins; 0 / Sialoglycoproteins; 0 / dentin sialophosphoprotein
  • [Other-IDs] NLM/ NIHMS164598; NLM/ PMC2847022
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48. Raveenthiran V: Pre-cancerous changes in the nasal mucosa of atrophic rhinitis: A preliminary report. Indian J Otolaryngol Head Neck Surg; 2005 Jan;57(1):28-9
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  • Epithelial dysplasia and in-situ malignant transformation were noted in one patient each.

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  • [Cites] J Laryngol Otol. 1975 Oct;89(10):1027-41 [1104729.001]
  • [Cites] Am J Otolaryngol. 1996 Mar-Apr;17(2):81-6 [8820180.001]
  • [Cites] ORL J Otorhinolaryngol Relat Spec. 1984;46(6):327-8 [6504514.001]
  • [Cites] Rhinology. 1987 Sep;25(3):213-5 [3672006.001]
  • (PMID = 23120119.001).
  • [ISSN] 2231-3796
  • [Journal-full-title] Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
  • [ISO-abbreviation] Indian J Otolaryngol Head Neck Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3451551
  • [Keywords] NOTNLM ; Atrophic Rhinitis—complication / Cancer / Metaplasia—Dysplasia / Neoplasia / Nose—Pathology / Ozena
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49. Damato B, Coupland SE: Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging. Clin Exp Ophthalmol; 2008 Nov;36(8):786-95
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  • Histologically, this abnormality can be categorized more precisely as either 'hypermelanosis' or 'conjunctival melanocytic intraepithelial neoplasia (C-MIN)'.
  • [MeSH-major] Conjunctival Neoplasms / classification. Melanoma / classification. Melanosis / classification. Terminology as Topic
  • [MeSH-minor] Humans. Neoplasm Staging

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  • (PMID = 19128387.001).
  • [ISSN] 1442-9071
  • [Journal-full-title] Clinical & experimental ophthalmology
  • [ISO-abbreviation] Clin. Experiment. Ophthalmol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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50. Kong WM, Sun JH: [Vulvar intraepithelial neoplasia and vaginal intraepithelial neoplasia]. Zhonghua Fu Chan Ke Za Zhi; 2009 Mar;44(3):161-2
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  • [Title] [Vulvar intraepithelial neoplasia and vaginal intraepithelial neoplasia].
  • [MeSH-major] Carcinoma in Situ. Vaginal Neoplasms. Vulvar Neoplasms

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  • (PMID = 19570436.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] Editorial
  • [Publication-country] China
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51. Yanke BV, Gonen M, Scardino PT, Kattan MW: Validation of a nomogram for predicting positive repeat biopsy for prostate cancer. J Urol; 2005 Feb;173(2):421-4
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  • Predictor variables studied in the nomogram were patient age, family history of prostate cancer, digital rectal examination, serum prostate specific antigen, prostate specific antigen slope, months from initial negative biopsy session, months from previous negative biopsy session, cumulative number of negative cores previously taken and history of high grade intraepithelial neoplasm or atypical small acinar proliferation.
  • [MeSH-major] Nomograms. Prostatic Neoplasms / pathology

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  • (PMID = 15643192.001).
  • [ISSN] 0022-5347
  • [Journal-full-title] The Journal of urology
  • [ISO-abbreviation] J. Urol.
  • [Language] eng
  • [Publication-type] Journal Article; Validation Studies
  • [Publication-country] United States
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52. Pai K, Pai S, Gupta A, Rao P, Renjhen P: Synchronous vulvar intraepithelial neoplasia (VIN) of warty type and cervical intraepithelial neoplasia (CIN): case report. Indian J Pathol Microbiol; 2006 Oct;49(4):585-7
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  • [Title] Synchronous vulvar intraepithelial neoplasia (VIN) of warty type and cervical intraepithelial neoplasia (CIN): case report.
  • Vulvar intraepithelial neoplasia is a precancerous lesion of the vulva, which has been referred to in the past with varied terminology.
  • We report a case of vaginal intraepithelial neoplasia and concomitant cervical intraepithelial neoplasia in a 30 year old female.
  • An attempt is made to put forth the recent terminology of vulvar intraepithelial neoplasia.
  • [MeSH-major] Carcinoma, Squamous Cell / complications. Cervical Intraepithelial Neoplasia / complications. Condylomata Acuminata / virology. Papillomaviridae. Vulvar Diseases / virology. Vulvar Neoplasms / complications. Vulvar Neoplasms / virology


53. Brentnall TA: Management strategies for patients with hereditary pancreatic cancer. Curr Treat Options Oncol; 2005 Sep;6(5):437-45
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  • The precursor lesion to pancreatic cancer is pancreatic intraepithelial neoplasia (PanIN), which is graded I to III depending upon the severity of the neoplastic change.
  • Surveillance for the early detection of cancer or intraepithelial neoplasia is possible in high-risk individuals and should be performed in centers with expertise.
  • Endoscopic ultrasound and endoscopic retrograde cholangiopancreatography can help identify those patients who have intraepithelial neoplasia and thus may warrant a tissue diagnosis.
  • [MeSH-major] Neoplastic Syndromes, Hereditary / diagnosis. Neoplastic Syndromes, Hereditary / therapy. Pancreatic Neoplasms / diagnosis. Pancreatic Neoplasms / therapy


54. Fraczek M, Wozniak Z, Ramsey D, Zatonski T, Krecicki T: Clinicopathologic significance and prognostic role of cyclin E and cyclin A expression in laryngeal epithelial lesions. Acta Otolaryngol; 2008 Mar;128(3):329-34
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  • [Title] Clinicopathologic significance and prognostic role of cyclin E and cyclin A expression in laryngeal epithelial lesions.
  • OBJECTIVE: The aim of the study was to elucidate a possible association between cyclin E and cyclin A expression and clinicopathologic factors and their potential role as prognostic markers for patients with laryngeal epithelial lesions.
  • MATERIALS AND METHODS: Expression of cyclins E and A, and Ki-67 was examined immunohistochemically in a formalin-fixed, paraffin-embedded series of 46 LSCC; 23 epithelial dysplasias (ED); and 21 normal mucosae (NM).
  • [MeSH-major] Carcinoma, Squamous Cell / genetics. Cyclin A / genetics. Cyclin E / genetics. Laryngeal Neoplasms / genetics. Respiratory Mucosa / pathology
  • [MeSH-minor] Adult. Aged. Cell Division / genetics. Cell Transformation, Neoplastic / genetics. Cell Transformation, Neoplastic / pathology. Female. Gene Expression Regulation, Neoplastic / genetics. Humans. Immunoenzyme Techniques. Ki-67 Antigen / genetics. Lymphatic Metastasis / genetics. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis

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  • (PMID = 17917837.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
  • [Chemical-registry-number] 0 / Cyclin A; 0 / Cyclin E; 0 / Ki-67 Antigen
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55. Beleznay KM, Levesque MA, Gill S: Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain. Curr Oncol; 2009 Sep;16(5):81-3
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  • Extramammary Paget disease is a rare intraepithelial neoplasm of the vulvar, penoscrotal, or perianal skin.

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  • [Cites] Dermatol Surg. 2004 Feb;30(2 Pt 2):341-4 [14871231.001]
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  • (PMID = 19862365.001).
  • [ISSN] 1718-7729
  • [Journal-full-title] Current oncology (Toronto, Ont.)
  • [ISO-abbreviation] Curr Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Canada
  • [Other-IDs] NLM/ PMC2768510
  • [Keywords] NOTNLM ; 5-fluorouracil / Paget disease / extramammary / metastatic
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56. Heinlein C, Krepulat F, Löhler J, Speidel D, Deppert W, Tolstonog GV: Mutant p53(R270H) gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis. Int J Cancer; 2008 Apr 15;122(8):1701-9
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  • We found that mutant p53(R270H) in bi-transgenic mice enhanced the transition from intraepithelial neoplasia to invasive carcinoma, resulting in a higher frequency of invasive carcinoma per gland and per mouse, a more severe tumor phenotype, and more frequent pulmonary metastasis.
  • [MeSH-major] Adenocarcinoma / genetics. Cell Transformation, Neoplastic / genetics. Genes, p53. Mammary Neoplasms, Experimental / genetics. Mutation, Missense. Tumor Suppressor Protein p53 / genetics
  • [MeSH-minor] Animals. Antigens, Polyomavirus Transforming. Arginine. Disease Models, Animal. Disease Progression. Female. Histidine. Lung Neoplasms / secondary. Mice. Mice, Inbred BALB C. Mice, Transgenic. Oncogenes. Phenotype. Point Mutation

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  • (PMID = 18092324.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Polyomavirus Transforming; 0 / Tumor Suppressor Protein p53; 4QD397987E / Histidine; 94ZLA3W45F / Arginine
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57. Harbaum L, Geigl JB, Volkholz H, Schwarzbraun T, Oschmautz H, Vieth M, Langner C: Sporadic gastric Peutz-Jeghers polyp with intraepithelial neoplasia. APMIS; 2009 Dec;117(12):941-3
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  • [Title] Sporadic gastric Peutz-Jeghers polyp with intraepithelial neoplasia.
  • [MeSH-major] Gastric Mucosa / pathology. Peutz-Jeghers Syndrome / pathology. Polyps / pathology. Stomach Neoplasms / pathology

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  • (PMID = 20078560.001).
  • [ISSN] 1600-0463
  • [Journal-full-title] APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • [ISO-abbreviation] APMIS
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] Denmark
  • [Chemical-registry-number] EC 2.7.1.- / STK11 protein, human; EC 2.7.11.1 / Protein-Serine-Threonine Kinases; EC 6.3.2.19 / MIB1 ligase, human; EC 6.3.2.19 / Ubiquitin-Protein Ligases
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58. Neumann H, Vieth M, Raithel M, Mudter J, Kiesslich R, Neurath MF: Confocal laser endomicroscopy for the in vivo detection of intraepithelial neoplasia in Peutz-Jeghers polyps. Endoscopy; 2010;42 Suppl 2:E139-40
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  • [Title] Confocal laser endomicroscopy for the in vivo detection of intraepithelial neoplasia in Peutz-Jeghers polyps.

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  • (PMID = 20405384.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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59. Kochs C, Hanneken S, Schulte KW, Reifenberger J: [Treatment of carcinoma in situ of erythema ab igne with photodynamic therapy]. Hautarzt; 2008 Oct;59(10):777-9
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  • Individual case reports of EAI with established epithelial dysplasia in the sense of carcinoma in situ have described good response of the neoplastic alterations to topical application of 5-fluorouracil or imiquimod.
  • [MeSH-major] Carcinoma in Situ / drug therapy. Erythema / drug therapy. Photochemotherapy / methods. Photosensitizing Agents / therapeutic use. Skin Neoplasms / drug therapy. Valerates / therapeutic use

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  • (PMID = 18773179.001).
  • [ISSN] 1432-1173
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Valerates
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60. Chalut KJ, Kresty LA, Pyhtila JW, Nines R, Baird M, Steele VE, Wax A: In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry. Cancer Epidemiol Biomarkers Prev; 2007 Feb;16(2):223-7
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  • [Title] In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry.
  • Optical spectroscopy was used to evaluate the transformation of nuclear morphology associated with intraepithelial neoplasia in an animal model of carcinogenesis.
  • In this pilot study, we have assessed the capability of angle-resolved low-coherence interferometry (a/LCI) to monitor in situ the neoplastic progression of hamster trachea epithelial tissue.
  • By using the depth resolution made possible by coherence gating, the a/LCI system has been adapted to the unique geometry of the hamster trachea to allow us to extract useful nuclear morphometric information from cells in the epithelial layer without the need for exogenous staining or tissue fixation.
  • Analysis of a/LCI nuclear morphology measurements has identified two important biomarkers of neoplastic transformation in hamster trachea epithelium, the size and the refractive index of epithelial cell nuclei.
  • By comparing the a/LCI measurements of these two biomarkers to pathologic classification, we distinguished nuclear morphology changes for normal tissue, low-grade dysplasia, and high-grade dysplasia.
  • [MeSH-major] Carcinoma in Situ / pathology. Interferometry / instrumentation. Neoplasms, Glandular and Epithelial / pathology. Trachea / pathology

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  • (PMID = 17301253.001).
  • [ISSN] 1055-9965
  • [Journal-full-title] Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • [ISO-abbreviation] Cancer Epidemiol. Biomarkers Prev.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CN / CN43308-13; United States / NCI NIH HHS / CN / N01-CN-43308
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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61. Worawongvasu R: A comparative study of the surfaces of normal oral epithelia and inflammatory hyperplasias by scanning electron microscopy. Ultrastruct Pathol; 2007 Jul-Aug;31(4):283-92
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  • The oral epithelia may show epithelial changes induced by the inflammation of the underlying lamina propria.
  • Light microscopically, the epithelial changes are similar to epithelial dysplasia seen in a premalignant lesion.
  • The epithelium of the parulis was nonkeratinized to parakeratinized with increased intercellular spaces and distinct epithelial changes similar to epithelial dysplasia.
  • Light microscopically, the oral epithelia overlying the intensely inflamed lamina propria showed distinct epithelial changes similar to epithelial dysplasia seen in a precancerous lesion but appeared normal except for markedly decreased numbers of microridges by scanning electron microscopy.

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  • (PMID = 17786829.001).
  • [ISSN] 1521-0758
  • [Journal-full-title] Ultrastructural pathology
  • [ISO-abbreviation] Ultrastruct Pathol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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62. Zhao P, Liu W, Lu YL: Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients. World J Gastroenterol; 2005 Sep 28;11(36):5735-8
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  • METHODS: FHIT protein expression was examined in 76 cases of gastric carcinoma, 58 cases of intraepithelial neoplasia, and 76 cases of corresponding normal mucosae by immunohistochemical method to analyze its relationship to histological grade, clinical stage, metastatic status and prognosis.
  • There was a significant difference in the expression of FHIT protein between cancer or adjacent intraepithelial neoplasia and normal gastric mucosa (P = 0.000).
  • [MeSH-major] Acid Anhydride Hydrolases / metabolism. Adenocarcinoma / metabolism. Gene Expression Regulation, Neoplastic. Neoplasm Proteins / metabolism. Stomach Neoplasms / metabolism

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  • (PMID = 16237777.001).
  • [ISSN] 1007-9327
  • [Journal-full-title] World journal of gastroenterology
  • [ISO-abbreviation] World J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / fragile histidine triad protein; EC 3.6.- / Acid Anhydride Hydrolases
  • [Other-IDs] NLM/ PMC4481500
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63. Cao D, Wilentz RE, Abbruzzese JL, Ho L, Maitra A: Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation. Int J Gastrointest Cancer; 2005;36(1):39-46
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  • BACKGROUND: Maspin is both overexpressed in tumors and inflammation, implicating a possible role in bridging inflammation and neoplasia.
  • Idiopathic inflammatory bowel disease (IBD) and IBD-associated dysplasias and carcinomas represent a prototype for studying the relationship between chronic inflammatory states and neoplasia.
  • AIM OF STUDY: To investigate expression of maspin in IBD and IBD-associated dysplasia and colorectal carcinoma.
  • METHODS: Immunohistochemical labeling of maspin was examined using tissue microarrays constructed from archival biopsy and resection tissue from 90 patients with 125 histologically defined lesions including 30 with inactive chronic IBD, 51 with active chronic IBD, 4 IBD-associated foci with epithelial changes indefinite for dysplasia (IFD), 7 with IBD-associated low-grade epithelial dysplasia (LGD), 8 with IBD-associated high grade epithelial dysplasia (HGD), and 25 with IBD-associated invasive colorectal adenocarcinomas.
  • In the multistage progression model of colitis-associated neoplasia, aberrant labeling was observed at the earliest stages, with 3/4 (75%) IFD foci, 6/7 (86%) LGD, and 8/8 (100%) HGD specimens expressing maspin, virtually always in a diffuse pattern.
  • CONCLUSIONS: Maspin is significantly overexpressed in both active IBD and colitis-associated dysplasia compared to either inactive IBD or normal colonic mucosa, suggesting a potential role in disease "flare" as well as neoplastic progression.
  • [MeSH-major] Adenocarcinoma / genetics. Cell Transformation, Neoplastic. Colitis / genetics. Colorectal Neoplasms / genetics. Inflammatory Bowel Diseases / genetics. Serpins / biosynthesis

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  • (PMID = 16227634.001).
  • [ISSN] 1537-3649
  • [Journal-full-title] International journal of gastrointestinal cancer
  • [ISO-abbreviation] Int J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / SERPIN-B5; 0 / Serpins
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64. Liu H, Merrell DS, Semino-Mora C, Goldman M, Rahman A, Mog S, Dubois A: Diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in nonhuman primates. Gastroenterology; 2009 Oct;137(4):1367-79.e1-6
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  • Starting at 2 and 5 years, respectively, gastric intestinal metaplasia and intraepithelial neoplasia developed in 3 EH monkeys but in no other groups.
  • Transcriptional analysis of biopsy specimens at 5 years revealed group-specific expression profiles, with striking changes in EH monkeys, plus a neoplasia-specific expression profile characterized by changes in multiple cancer-associated genes.
  • CONCLUSIONS: Gastric intraglandular neoplasia is induced in primates when H pylori infection is associated with consumption of a carcinogen similar to the nitrosamines found in pickled vegetables, suggesting that H pylori and the carcinogen synergistically induce gastric neoplasia in primates.


65. Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC: Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A; 2005 Jul 19;102(29):10238-43
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  • [Title] Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
  • Mice with heterozygous deletion of the PTEN tumor suppressor gene develop a range of epithelial neoplasia as well as lymphoid hyperplasia.
  • Here, we examined the effect of deleting various regulatory subunits of PI3K (p85alpha and p85beta) on epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice.
  • In contrast, the incidence of prostate intraepithelial neoplasia was not significantly altered in PTEN+/- mice heterozygous for p85alpha or null for p85beta, whereas the fraction of proliferating cells in prostate intraepithelial neoplasia was reduced in mice lacking p85beta.

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  • (PMID = 16006513.001).
  • [ISSN] 0027-8424
  • [Journal-full-title] Proceedings of the National Academy of Sciences of the United States of America
  • [ISO-abbreviation] Proc. Natl. Acad. Sci. U.S.A.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P01 CA089021; United States / NIGMS NIH HHS / GM / R01 GM041890; United States / NCI NIH HHS / CA / P01-CA089021
  • [Publication-type] Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Forkhead Transcription Factors; 0 / Foxo1 protein, mouse; 0 / Ki-67 Antigen; 0 / Mki67 protein, mouse; 0 / Transcription Factors; 0 / Tumor Suppressor Proteins; EC 2.7.1.- / Phosphatidylinositol 3-Kinases; EC 3.1.3.48 / Protein Tyrosine Phosphatases; EC 3.1.3.48 / Pten protein, mouse; EC 3.1.3.67 / PTEN Phosphohydrolase
  • [Other-IDs] NLM/ PMC1174923
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66. Aishima S, Nishihara Y, Tsujita E, Taguchi K, Soejima Y, Taketomi A, Ikeda Y, Maehara Y, Tsuneyoshi M: Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia. Hum Pathol; 2008 Jun;39(6):939-47
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  • [Title] Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia.
  • We describe the histopathologic features of 2 cases of biliary neoplasia with extensive intraductal spread arising in liver cirrhosis.
  • The prevalence of this type of biliary neoplasia may be 0.4% from the review of 468 cases of cirrhotic liver.
  • We believe that the possibility of biliary neoplasia with extensive intraductal spread should be considered to be a variant of biliary intraepithelial neoplasia.
  • [MeSH-major] Bile Ducts, Intrahepatic / pathology. Biliary Tract Neoplasms / pathology. Cholangiocarcinoma / pathology. Liver Cirrhosis, Alcoholic / pathology
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma, Hepatocellular / complications. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / pathology. Cell Count. Cell Proliferation. Hepatitis C, Chronic / complications. Hepatitis C, Chronic / metabolism. Hepatitis C, Chronic / pathology. Humans. Immunoenzyme Techniques. Keratins / metabolism. Liver Transplantation. Male. Middle Aged. Mucins / metabolism. Neoplasms, Multiple Primary. Treatment Outcome

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  • (PMID = 18430455.001).
  • [ISSN] 1532-8392
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Mucins; 68238-35-7 / Keratins
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67. Villarroel Dorrego M, Speight PM, Barrett AW: The immunohistology of CD40 in human oral epithelium in health and disease. J Oral Pathol Med; 2006 May;35(5):268-73
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  • Expression was lost in nine of 33 (27%) epithelial dysplasias, seven of which were severe.
  • Expression is lost in approximately one-third of oral epithelial dysplasias and OSCC.
  • [MeSH-major] Antigens, CD40 / immunology. Carcinoma, Squamous Cell / immunology. Keratinocytes / immunology. Mouth Mucosa / immunology. Mouth Neoplasms / immunology

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  • (PMID = 16630289.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Antigens, CD40
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68. Santoso JT, Long M, Crigger M, Wan JY, Haefner HK: Anal intraepithelial neoplasia in women with genital intraepithelial neoplasia. Obstet Gynecol; 2010 Sep;116(3):578-82
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  • [Title] Anal intraepithelial neoplasia in women with genital intraepithelial neoplasia.
  • OBJECTIVE: To estimate the prevalence of anal intraepithelial neoplasia in heterosexual women with genital intraepithelial neoplasia, and to compare anal cytology with colposcopy for their effectiveness in anal intraepithelial neoplasia screening.
  • METHODS: Women with confirmed intraepithelial neoplasia on the cervix, vagina, or vulva were referred for gynecologic oncology care.
  • Of the 205 patients with genital intraepithelial neoplasia, 25 patients (12.2%) had biopsy-proven anal intraepithelial neoplasia.
  • Twelve patients (5.9%) had abnormal anal cytology (nine with atypical squamous cells of undetermined significance [ASC-US], three with low-grade squamous intraepithelial lesions [LSIL]).
  • None of the nine patients with anal ASC-US had biopsy-proven anal intraepithelial neoplasia.
  • Of the three patients with anal LSIL, two had anal intraepithelial neoplasia II and one had condyloma on biopsy.
  • However, 78 patients (38%) had abnormal anoscopy findings that resulted in 25 biopsy-proven anal intraepithelial neoplasias (8 anal intraepithelial neoplasia I, 5 anal intraepithelial neoplasia II, 12 anal intraepithelial neoplasia III)), condylomas (n=11), and hyperkeratosis (n=8).
  • Anoscopy identified 32% (25 patients) with anal intraepithelial neoplasia out of 78 abnormal anoscopic examinations.
  • In diagnosing anal intraepithelial neoplasia, anoscopy has 100% sensitivity and 71% specificity; anal cytology has 8% sensitivity and 94% specificity.
  • CONCLUSION: Patients with cervical, vulvar, and vaginal intraepithelial neoplasia have 12.2% prevalence of anal intraepithelial neoplasia and should be screened with high-resolution anoscopy.
  • In anal intraepithelial neoplasia screening, anoscopy is more sensitive but less specific than anal cytology.
  • [MeSH-major] Anus Neoplasms / epidemiology. Carcinoma in Situ / epidemiology. Genital Neoplasms, Female / epidemiology

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  • [CommentIn] Obstet Gynecol. 2010 Sep;116(3):566-7 [20733435.001]
  • [ErratumIn] Obstet Gynecol. 2010 Nov;116(5):1224
  • (PMID = 20733438.001).
  • [ISSN] 1873-233X
  • [Journal-full-title] Obstetrics and gynecology
  • [ISO-abbreviation] Obstet Gynecol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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69. Arratia-Maqueo JA, Cortés-González JR, Garza-Cortes R, Gómez-Guerra LS: Prospective study of prostate cancer's detection rate at our hospital in Northeast Mexican patients with PSA values between 2.6 y 4 ng/ml. Arch Esp Urol; 2010 May;63(4):287-90
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  • EXCLUSION CRITERIA: known history of PCa, intraepithelial neoplasia or Positive DRE.
  • [MeSH-major] Prostate-Specific Antigen / blood. Prostatic Neoplasms / blood. Prostatic Neoplasms / diagnosis


70. Scheiden R, Pescatore P, Capesius C: Oesophageal intraepithelial and invasive neoplasia of squamous cell type: epidemiology and outcome in Luxembourg, 1980-2001. Acta Gastroenterol Belg; 2005 Jul-Sep;68(3):302-7
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  • [Title] Oesophageal intraepithelial and invasive neoplasia of squamous cell type: epidemiology and outcome in Luxembourg, 1980-2001.
  • BACKGROUND AND STUDY AIMS: Oesophageal intraepithelial neoplasia of squamous cell type (INSC) and invasive oesophageal squamous cell carcinoma (IOSCC) are infrequent diseases in Western Europe.
  • PATIENTS AND METHODS: The National Morphologic Tumour Registry allowed to review the data of all patients with INSC and IOSCC diagnosed between 1980 and 2001 and to record the time trends in incidence, the oncologic co-morbidity and the outcome of the patients.
  • The overall age-standardized (world) incidence rate of intraepithelial neoplasia and invasive squamous cell carcinoma were 0.2 and 4.2 per 10(5), respectively, the M/F-ratio for both 3:1.
  • There was a 2-fold increase of the intraepithelial neoplasia incidence in the last decade.
  • CONCLUSIONS: The incidence of invasive oesophageal squamous cell carcinomas remains stable whereas that of detected intraepithelial squamous cell neoplasias is remarkably low, indicating potential underdiagnosis.
  • [MeSH-major] Carcinoma, Squamous Cell. Esophageal Neoplasms
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Incidence. Luxembourg / epidemiology. Male. Middle Aged. Neoplasm Invasiveness. Prognosis. Retrospective Studies. Survival Rate / trends

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  • (PMID = 16268415.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Belgium
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71. Zen Y, Fujii T, Itatsu K, Nakamura K, Konishi F, Masuda S, Mitsui T, Asada Y, Miura S, Miyayama S, Uehara T, Katsuyama T, Ohta T, Minato H, Nakanuma Y: Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol; 2006 Sep;19(9):1243-54
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  • [Title] Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct.
  • Intraepithelial neoplasm was observed within non-dilated adjacent bile ducts, suggesting a direct luminal communication between the cystic tumors and the bile duct.
  • These clinicopathological features resembled those of intraductal papillary neoplasm of the bile duct, which had been reported as a biliary counterpart of pancreatic intraductal papillary mucinous neoplasm.
  • In conclusion, biliary cystic tumors with bile duct communication could be regarded as intraductal papillary neoplasm with a prominent cystic dilatation of the bile duct and mucin retention, rather than true biliary cystic neoplasms.
  • [MeSH-major] Adenocarcinoma, Papillary / pathology. Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic / pathology. Cholangiocarcinoma / pathology. Cystadenocarcinoma / pathology. Cystadenoma / pathology

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  • [Copyright] Published online 2 June 2006.
  • (PMID = 16741522.001).
  • [ISSN] 0893-3952
  • [Journal-full-title] Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • [ISO-abbreviation] Mod. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Homeodomain Proteins; 0 / MUC2 protein, human; 0 / Mucin-1; 0 / Mucin-2; 0 / Mucins; 0 / Trans-Activators; 156560-97-3 / Cdx-2-3 protein
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72. Jiménez P, Piazuelo E, Cebrian C, Ortego J, Strunk M, García-Gonzalez MA, Santander S, Alcedo J, Lanas A: Prostaglandin EP2 receptor expression is increased in Barrett's oesophagus and oesophageal adenocarcinoma. Aliment Pharmacol Ther; 2010 Feb 1;31(3):440-51
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  • METHODS: Expression was determined in oesophageal biopsies from 85 patients with oesophagitis, Barrett's metaplasia, intraepithelial neoplasia, oesophageal adenocarcinoma and normal oesophagus.
  • COX-2 and, especially, EP2 were increased in the Barrett's metaplasia-intraepithelial neoplasia-adenocarcinoma sequence.
  • [MeSH-major] Adenocarcinoma / pathology. Barrett Esophagus / pathology. Cyclooxygenase 1 / metabolism. Esophageal Neoplasms / pathology. RNA, Messenger / metabolism. Receptors, Prostaglandin E / metabolism

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  • (PMID = 19843025.001).
  • [ISSN] 1365-2036
  • [Journal-full-title] Alimentary pharmacology & therapeutics
  • [ISO-abbreviation] Aliment. Pharmacol. Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / PTGER2 protein, human; 0 / RNA, Messenger; 0 / Receptors, Prostaglandin E; 0 / Receptors, Prostaglandin E, EP2 Subtype; EC 1.14.99.1 / Cyclooxygenase 1
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73. Namba R, Young LJ, Maglione JE, McGoldrick ET, Liu S, Wurz GT, DeGregorio MW, Borowsky AD, MacLeod CL, Cardiff RD, Gregg JP: Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ. Breast Cancer Res; 2005;7(6):R881-9
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  • This model consists of a set of serially transplanted lines of genetically engineered mouse mammary intraepithelial neoplasia (MIN) outgrowth (MIN-O) tissue that have stable characteristics.

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  • (PMID = 16280035.001).
  • [ISSN] 1465-542X
  • [Journal-full-title] Breast cancer research : BCR
  • [ISO-abbreviation] Breast Cancer Res.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / CA89140-01; United States / NCI NIH HHS / CA / R01 CA089140; United States / NCRR NIH HHS / RR / U42 RR014905; United States / NCRR NIH HHS / RR / U42RR14905; United States / NCI NIH HHS / CA / R01CA81376
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Receptors, Estrogen; 0 / Selective Estrogen Receptor Modulators; 094ZI81Y45 / Tamoxifen; B0P231ILBK / Ospemifene
  • [Other-IDs] NLM/ PMC1410776
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74. Hurlstone DP, Brown S: Techniques for targeting screening in ulcerative colitis. Postgrad Med J; 2007 Jul;83(981):451-60
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  • New endoscopic techniques and technologies including the use of dye sprays, "chromoendoscopy", high magnification chromoscopic colonoscopy and recently chromoscopic assisted confocal laser scanning in vivo endomicroscopy have now been introduced to improve the diagnostic yield of intraepithelial neoplasia at screening colonoscopy.
  • This review details the true "risk" of colorectal cancer complicating ulcerative colitis, discusses the objective evidence to support current endoscopic screening guidelines, and describes the imminent technological paradigm shift about to occur in the endoscopic management and detection of intraepithelial neoplasia.
  • [MeSH-major] Colitis, Ulcerative / diagnosis. Colorectal Neoplasms / complications. Mass Screening / methods

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  • (PMID = 17621613.001).
  • [ISSN] 1469-0756
  • [Journal-full-title] Postgraduate medical journal
  • [ISO-abbreviation] Postgrad Med J
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Number-of-references] 76
  • [Other-IDs] NLM/ PMC2600104
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75. Guven S, Guvendag Guven ES, Ayhan A, Gokoz A: Recurrence of high-grade squamous intraepithelial neoplasia in neovagina: case report and review of the literature. Int J Gynecol Cancer; 2005 Nov-Dec;15(6):1179-82
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  • [Title] Recurrence of high-grade squamous intraepithelial neoplasia in neovagina: case report and review of the literature.
  • A 33-year-old multiparous woman was referred for vulvar intraepithelial neoplasia, vaginal intraepithelial neoplasia, and cervical intraepithelial neoplasia, underwent skinning vulvectomy with perianal excision, total vaginectomy, vaginal hysterectomy, and vaginal reconstruction with split-thickness skin graft.
  • Ten years after initial surgery, the recurrence as a high-grade intraepithelial neoplasia in the upper one third of neovagina was detected.
  • [MeSH-major] Carcinoma in Situ / surgery. Neoplasm Recurrence, Local / surgery. Vaginal Neoplasms / surgery. Vulvar Neoplasms / surgery
  • [MeSH-minor] Adult. Cervical Intraepithelial Neoplasia / surgery. Female. Gynecologic Surgical Procedures. Humans. Reconstructive Surgical Procedures. Reoperation. Skin Transplantation. Treatment Outcome

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  • (PMID = 16343208.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 9
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76. Baughman R: Testing your diagnostic skills. Case no. 1: epithelial dysplasia. Todays FDA; 2006 Feb;18(2):20, 22
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  • [Title] Testing your diagnostic skills. Case no. 1: epithelial dysplasia.

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  • (PMID = 16598894.001).
  • [ISSN] 1048-5317
  • [Journal-full-title] Today's FDA : official monthly journal of the Florida Dental Association
  • [ISO-abbreviation] Todays FDA
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Plant Extracts
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77. Tomas D, Zovak M, Cicek S, Sulentić P, Jukić Z, Kruslin B: Mucinous cystadenoma arising in an isolated ileal duplication cyst. J Gastrointest Cancer; 2007;38(2-4):127-30
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  • Pathohistological examination showed mucinous cystadenoma with high-grade epithelial dysplasia in the isolated ileal duplication cyst.
  • The presence of epithelial dysplasia found in duplication cyst suggested potential to undergo malignant transformation.
  • [MeSH-major] Cystadenoma, Mucinous / pathology. Cysts / pathology. Ileal Neoplasms / pathology

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  • (PMID = 19089665.001).
  • [ISSN] 1941-6628
  • [Journal-full-title] Journal of gastrointestinal cancer
  • [ISO-abbreviation] J Gastrointest Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Kraft M, Glanz H, von Gerlach S, Wisweh H, Lubatschowski H, Arens C: Clinical value of optical coherence tomography in laryngology. Head Neck; 2008 Dec;30(12):1628-35
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  • The objective of this study is to evaluate microlaryngoscopy in combination with OCT compared with microlaryngoscopy alone (ie, without OCT) in supplying a specific diagnosis, predicting invasive tumor growth and epithelial dysplasia in the larynx.
  • In particular, our results in malignant and benign pathologies were correct in 93% each, and the exact grade of dysplasia could be predicted in 71% of precancerous lesions.
  • Microlaryngoscopy with OCT presented a higher sensitivity than microlaryngoscopy alone in predicting invasive tumor growth (93% vs 87%) and epithelial dysplasia (78% vs 66%), but the specificity and accuracy were comparable in both methods.
  • [MeSH-minor] Biopsy. Hospitals, University. Humans. Intraoperative Period. Laryngeal Neoplasms / pathology. Laryngeal Neoplasms / radiography. Laryngoscopy / methods. Precancerous Conditions / pathology. Precancerous Conditions / radiography. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity

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  • [Copyright] (c) 2008 Wiley Periodicals, Inc.
  • (PMID = 18767182.001).
  • [ISSN] 1097-0347
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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79. Chen QY, Bian ML, Zhang XY, Ou H, Ma L: [Detection of multiple human papillomavirus infection in cervical specimens by flow fluorescent hybridization]. Zhonghua Yi Xue Za Zhi; 2009 Apr 7;89(13):901-5
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  • METHODS: Cervical exfoliated cell specimens were collected from 301 randomly selected women accepting opportunistic screening for cervical lesions with the cytological results and hybrid capture 2 (HC-2) assay>or=atypical squamous cells of uncertain significance (ASC-US), 48 with the pathological diagnosis>or=cervical intraepithelial neoplasia (CIN)2 (case group) and 253 with normal histological result or only inflammation (control group), aged (34+/-9) (21-59).
  • [MeSH-major] Cervix Uteri / virology. Papillomavirus Infections / diagnosis. Superinfection. Uterine Cervical Neoplasms / diagnosis


80. Loddenkemper C: Diagnostic standards in the pathology of inflammatory bowel disease. Dig Dis; 2009;27(4):576-83
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  • There is a strong relationship between the presence of intraepithelial neoplasia (IEN) in patients with CD or UC and colon cancer.
  • Furthermore, distinction between dysplasia-associated lesions or masses (DALM) and sporadic adenoma-like masses (ALM) is crucial as prophylactic colectomy is usually recommended for DALM and polypectomy may be sufficient for ALM.
  • [MeSH-minor] Colonic Neoplasms / complications. Colonic Neoplasms / pathology. Diagnosis, Differential. Humans. Iatrogenic Disease. Lymphoproliferative Disorders / complications

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  • (PMID = 19897978.001).
  • [ISSN] 1421-9875
  • [Journal-full-title] Digestive diseases (Basel, Switzerland)
  • [ISO-abbreviation] Dig Dis
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Switzerland
  • [Number-of-references] 16
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81. Takenaka R, Kawahara Y, Okada H, Hori K, Inoue M, Kawano S, Tanioka D, Tsuzuki T, Uemura M, Ohara N, Tominaga S, Onoda T, Yamamoto K: Narrow-band imaging provides reliable screening for esophageal malignancy in patients with head and neck cancers. Am J Gastroenterol; 2009 Dec;104(12):2942-8
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  • Detection of SCC and high-grade intraepithelial neoplasia (HGIN) was conducted.
  • Although 1 of these lesions was diagnosed as HGIN, 21 lesions were diagnosed as low-grade intraepithelial neoplasia or lesions without atypical findings.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Esophageal Neoplasms / secondary. Esophagoscopy / methods. Head and Neck Neoplasms / pathology

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  • (PMID = 19623169.001).
  • [ISSN] 1572-0241
  • [Journal-full-title] The American journal of gastroenterology
  • [ISO-abbreviation] Am. J. Gastroenterol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Coloring Agents; 0 / Iodides; T66M6Y3KSA / Lugol's solution
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82. Du GF, Li CZ, Chen HZ, Chen XM, Xiao Q, Cao ZG, Shang SH, Cai X: Rose bengal staining in detection of oral precancerous and malignant lesions with colorimetric evaluation: a pilot study. Int J Cancer; 2007 May 1;120(9):1958-63
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  • The sensitivity and specificity to detect epithelial dysplasia (DP) and oral squamous cell carcinoma were 93.9 and 73.7%, respectively.
  • [MeSH-major] Colorimetry / methods. Mouth Neoplasms / diagnosis. Precancerous Conditions / diagnosis. Rose Bengal

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  • [Copyright] (c) 2007 Wiley-Liss, Inc.
  • (PMID = 17245698.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 1ZPG1ELY14 / Rose Bengal
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83. Tavassoli FA: Lobular and ductal intraepithelial neoplasia. Pathologe; 2008 Nov;29 Suppl 2:107-11
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  • [Title] Lobular and ductal intraepithelial neoplasia.
  • Lobular and ductal intraepithelial neoplasias reflect proliferations of immunophenotypically variable, biologically and morphologically diverse cells with a potential, not always realized, for progression to carcinoma by breaking through the barriers of the myoepithelial cell layer and basement membrane, ultimately invading the stroma.
  • Starting with the lobular and then the ductal proliferations, this review will address the evolution of our understanding of these lesions; the problems associated with the conventional terminology of ductal hyperplasia, atypical hyperplasia, and carcinoma in situ; and reasons for and advantages of the intraepithelial neoplasia terminology.
  • [MeSH-minor] Adult. Biopsy. Breast / pathology. Cell Transformation, Neoplastic / pathology. Diagnosis, Differential. Disease Progression. Female. Humans. Mastectomy. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery

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  • (PMID = 18836725.001).
  • [ISSN] 1432-1963
  • [Journal-full-title] Der Pathologe
  • [ISO-abbreviation] Pathologe
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 30
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84. Van der Kwast TH, Zlotta AR, Fleshner N, Jewett M, Lopez-Beltran A, Montironi R: Thirty-five years of noninvasive bladder carcinoma: a plea for the use of papillary intraurothelial neoplasia as new terminology. Anal Quant Cytol Histol; 2008 Dec;30(6):309-15
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  • [Title] Thirty-five years of noninvasive bladder carcinoma: a plea for the use of papillary intraurothelial neoplasia as new terminology.
  • Since the introduction of the World Health Organization (WHO) 1973 terminology for bladder cancer, noninvasive epithelial bladder tumors have consistently been labeled bladder carcinomas.
  • In the WHO 2004 classification the removal of the "carcinoma" label from a small subset of noninvasive bladder carcinomas with indolent behavior created the entity of papillary urothelial neoplasms of low malignant potential, but the remaining noninvasive carcinomas of the urothelial tract retained this label.
  • In line with the tendency during the last few decades to label flat precancerous lesions of various organs intraepithelial neoplasms, we may now also refer to dysplasia and carcinoma in situ of the urinary tract as low and high grade intraurothelial neoplasia, respectively.

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  • (PMID = 19160695.001).
  • [ISSN] 0884-6812
  • [Journal-full-title] Analytical and quantitative cytology and histology
  • [ISO-abbreviation] Anal. Quant. Cytol. Histol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Wang CY, Tsai T, Chiang CP, Chen HM, Chen CT: Improved diagnosis of oral premalignant lesions in submucous fibrosis patients with 5-aminolevulinic acid induced PpIX fluorescence. J Biomed Opt; 2009 Jul-Aug;14(4):044026
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  • We investigate the possibility of using ALA-derived PpIX fluorescence spectroscopy for the detection of epithelial hyperkeratosis (EH) or epithelial dysplasia (ED) lesions in oral submucous fibrosis (OSF) patients that could not be found by autofluorescence spectroscopy.
  • Twenty percent of ALA solution gel was applied onto oral neoplasia and surrounding normal tissue [normal oral mucosa (NOM)] for 90 min.
  • [MeSH-major] Aminolevulinic Acid. Image Enhancement / methods. Mouth Neoplasms / diagnosis. Oral Submucous Fibrosis / diagnosis. Precancerous Conditions / diagnosis. Protoporphyrins. Spectrometry, Fluorescence / methods

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  • (PMID = 19725737.001).
  • [ISSN] 1560-2281
  • [Journal-full-title] Journal of biomedical optics
  • [ISO-abbreviation] J Biomed Opt
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Protoporphyrins; 553-12-8 / protoporphyrin IX; 88755TAZ87 / Aminolevulinic Acid
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86. Dwivedi PP, Mallya S, Dongari-Bagtzoglou A: A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia. Med Mycol; 2009 Mar;47(2):157-67
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  • [Title] A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia.
  • Clinical observations indicate a significant positive association between oral Candida carriage or infection and oral epithelial dysplasia/neoplasia.
  • The aim of this study was to test whether C. albicans is able to promote epithelial dysplasia or carcinoma in a mouse model of infection where a carcinogen (4 Nitroquinoline 1-oxide [4NQO]) was used as initiator of neoplasia.
  • The expression of Ki-67 and p16, two cell-cycle associated proteins that are frequently deregulated in oral dysplasia/neoplasia, was also tested in these lesions.
  • In conclusion, we showed that C. albicans plays a role in the promotion of oral dysplasia in a mouse model of infection when 4NQO was used as initiator of oral neoplasia.

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  • (PMID = 18608888.001).
  • [ISSN] 1369-3786
  • [Journal-full-title] Medical mycology
  • [ISO-abbreviation] Med. Mycol.
  • [Language] ENG
  • [Grant] United States / NIDCR NIH HHS / DE / R01 DE013986-07A1; United States / NCRR NIH HHS / RR / RR006192-155326; United States / NCRR NIH HHS / RR / M01 RR006192-155326; United States / NIDCR NIH HHS / DE / DE013986-07A1; United States / NCRR NIH HHS / RR / M01 RR006192; United States / NIDCR NIH HHS / DE / R01 DE013986; United States / NIDCR NIH HHS / DE / R01 DE 13986
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Carcinogens; 56-57-5 / 4-Nitroquinoline-1-oxide
  • [Other-IDs] NLM/ NIHMS110530; NLM/ PMC2730668
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87. Grippo PJ, Tuveson DA: Deploying mouse models of pancreatic cancer for chemoprevention studies. Cancer Prev Res (Phila); 2010 Nov;3(11):1382-7
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  • With the advent of mouse models that recapitulate the cellular and molecular pathology of pancreatic neoplasia and cancer, it is now feasible to recruit and deploy these models for the evaluation of various chemopreventive and/or anticancer regimens.
  • Currently, there are over a dozen models available, which range from homogeneous preneoplastic lesions with remarkable similarity to human pancreatic intraepithelial neoplasms to models with a more heterogeneous population of lesions including cystic papillary and mucinous lesions.
  • [MeSH-major] Carcinoma, Pancreatic Ductal / prevention & control. Chemoprevention / methods. Disease Models, Animal. Pancreatic Neoplasms / prevention & control

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  • [Copyright] ©2010 AACR.
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  • (PMID = 21045161.001).
  • [ISSN] 1940-6215
  • [Journal-full-title] Cancer prevention research (Philadelphia, Pa.)
  • [ISO-abbreviation] Cancer Prev Res (Phila)
  • [Language] eng
  • [Grant] United Kingdom / Cancer Research UK / / A10211; United States / NCI NIH HHS / CA / R01 CA161283
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC3242034; NLM/ UKMS32212
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88. Jouret-Mourin A, Sempoux C, Duc KH, Geboes K: Usefulness of histopathological markers in diagnosing Barrett's intraepithelial neoplasia (dysplasia). Acta Gastroenterol Belg; 2009 Oct-Dec;72(4):425-32
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  • [Title] Usefulness of histopathological markers in diagnosing Barrett's intraepithelial neoplasia (dysplasia).
  • The progression from normal mucosa to adenocarcinoma has been associated with genetic and morphological traits regrouped under the term "intraepithelial neoplasia" (IEN) according to the Vienna classification.
  • [MeSH-major] Barrett Esophagus / pathology. Biomarkers, Tumor / analysis. Carcinoma in Situ / pathology. Esophageal Neoplasms / pathology

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  • (PMID = 20163037.001).
  • [ISSN] 1784-3227
  • [Journal-full-title] Acta gastro-enterologica Belgica
  • [ISO-abbreviation] Acta Gastroenterol. Belg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Belgium
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Ki-67 Antigen; EC 5.1.- / Racemases and Epimerases; EC 5.1.99.4 / alpha-methylacyl-CoA racemase
  • [Number-of-references] 42
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89. Lemus-Rocha SR, Andrade-Padilla MA, Rivera-Ibarra DB, Basavilvazo-Rodríguez MA, Hinojosa-Cruz JC, Veloz-Martínez MG: [Clinical aptitude of residents that attend patients with the cervical intraepithelial neoplasia]. Rev Med Inst Mex Seguro Soc; 2009 Nov-Dec;47(6):683-8
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  • [Title] [Clinical aptitude of residents that attend patients with the cervical intraepithelial neoplasia].
  • [Transliterated title] Aptitud clínica de médicos residentes en la atención de pacientes con neoplasia intraepitelial cervical.
  • OBJECTIVE: To build, validate and apply an instrument to evaluate the clinical aptitude in intraepitelial cervical neoplasia (ICN) in residents.
  • [MeSH-major] Cervical Intraepithelial Neoplasia. Clinical Competence. Internship and Residency / standards. Uterine Cervical Neoplasms


90. Sierra-Torres CH, Acosta-Aragón MP, Orejuela-Aristizabal L: [Papillomavirus and factors associated with high-risk, cervical intraepithelial neoplasia in Cauca, Colombia]. Rev Salud Publica (Bogota); 2006 May;8 Suppl 1:47-58
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  • [Title] [Papillomavirus and factors associated with high-risk, cervical intraepithelial neoplasia in Cauca, Colombia].
  • [Transliterated title] Papilomavirus y factores asociados a neoplasia intraepitelial cervical de alto grado en Cauca, Colombia.
  • OBJECTIVE: Evaluating the role of the main factors associated with high-risk cervical intraepithelial neoplasia in women from the Cauca Department in Colombia.
  • RESULTS: The study confirmed association between HPV and the risk of cervical neoplasia (OR = 19.0; 95% CI = 8.20-44.2).
  • The data suggested that multiparity (OR = 4.1; 95% CI = 1.62-10.6) and exposure to carcinogens present in wood-smoke (OR = 7.3; 95% CI = 3.00-19.4) are important co-factors for cervical neoplasia given the presence of HPV.
  • CONCLUSIONS: These results provide valuable information for public health institutions to develop better cervical neoplasia prevention programmes.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / epidemiology. Papillomaviridae / isolation & purification. Papillomavirus Infections / epidemiology. Uterine Cervical Neoplasms / epidemiology

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  • (PMID = 16925121.001).
  • [ISSN] 0124-0064
  • [Journal-full-title] Revista de salud pública (Bogotá, Colombia)
  • [ISO-abbreviation] Rev Salud Publica (Bogota)
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Colombia
  • [Chemical-registry-number] 0 / Contraceptives, Oral, Hormonal; 0 / DNA Probes, HPV; 0 / Smoke
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91. Radović S, Vukobrat-Bijedić Z, Selak I, Babić M: Expression of p53, bcl-2, and Ki-67 proteins in the inflammatory regenerative and dysplastic epithelial lesions of flat colonic mucosa. Bosn J Basic Med Sci; 2006 Feb;6(1):39-45
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  • [Title] Expression of p53, bcl-2, and Ki-67 proteins in the inflammatory regenerative and dysplastic epithelial lesions of flat colonic mucosa.
  • Biopsy specimens from 270 patients were examined: 74 were classified as inflammatory-regenerative and 196 as dysplastic lesions (108 mild, 58 moderate, and 30 severe dysplasia).
  • The expression of all three proteins was assessed on the basis of location, quantity, and intensity of immunostaining, by counting antigen positive cells, in comparison with normal mucosa and adenocarcinoma. p53 protein appears only in sporadic cases (6.6%) of severe dysplasia.
  • Bcl-2 expression appears significantly (p<0.005) more often in cases of mild dysplasia (61.1%) compared to inflammatory-regenerative mucosa (14.8%).
  • In cases of mild dysplasia, bcl-2 positive cells were spreading from the lower third to the middle third of the crypts.
  • Bcl-2 expression was maintained through the stadiums of moderate and severe dysplasia (75.8%), where antigen positive cells were found all along the crypts.
  • A significant increase (p<0.005) in the expression of nuclear protein Ki-67 was noticed in the stadiums of moderate (labelling index =26.3) compared to mild dysplasia (labelling index=16.7), and severe (labelling index=36.7) compared to moderate dysplasia, where the zone of cellular proliferation was widen along the whole crypt length.
  • In the process of the development of epithelial dysplasia in the flat mucosa of colon a degree of the gene p53 alteration is low and appears only in sporadic cases of severe dysplasia.
  • Increased expression of Ki-67 protein speaks in favour of an increased cellular proliferation which, together with the above mentioned mechanisms, is involved in the process of occurrence and progression of epithelial dysplasia in the flat mucosa of colon.

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  • (PMID = 16533178.001).
  • [ISSN] 1512-8601
  • [Journal-full-title] Bosnian journal of basic medical sciences
  • [ISO-abbreviation] Bosn J Basic Med Sci
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
  • [Chemical-registry-number] 0 / Ki-67 Antigen; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / TP53 protein, human; 0 / Tumor Suppressor Protein p53
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92. Frega A, Scirpa P, Corosu R, Verrico M, Scarciglia ML, Primieri MR, Palazzo A, Iacovelli R, Moscarini M: Clinical management and follow-up of squamous intraepithelial cervical lesions during pregnancy and postpartum. Anticancer Res; 2007 Jul-Aug;27(4C):2743-6
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  • [Title] Clinical management and follow-up of squamous intraepithelial cervical lesions during pregnancy and postpartum.
  • Data on the spontaneous evolution of an intraepithelial neoplasia during pregnancy are quite diverse.
  • Of dysplasia cases diagnosed during pregnancy, 10%-70% regress and sometimes even disappear postpartum, while persistence in the severity of cervical neoplasia is reported in 25%-47% and progression occurs in 3%-30%.
  • The objective of the study was to assess proper management of squamous intraepithelial lesion (SIL) during and after pregnancy, to assess regression, persistence and risk of progression and the predictive role of HPV tests.
  • RESULTS: Of the 31 patients with abnormal cytology, histological analysis revealed 10 cervical intraepithelial neoplasia (CIN) 1, 5 CIN 2 and 16 CIN 3.
  • [MeSH-major] Cervical Intraepithelial Neoplasia / surgery. Pregnancy Complications, Neoplastic / surgery. Uterine Cervical Neoplasms / surgery


93. Chen HB, Liu DX, Wang L, Chen Y, Song SL, Yang LL, Hao Y, Yang JL: [Immunoreactivity of monoclonal anti-p21Ras antibody KGH-R1 in colorectal benign and malignant lesions]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2010 Dec;26(12):1206-9
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  • METHODS: Immunohistochemical staining was performed using monoclonal anti-p21ras antibody KGH-R1 prepared in our laboratory, in formalin-fixed, paraffin-embedded colorectal samples including normal colorectal tissues, colorectal inflammatory polyps, colorectal low-grade intraepithelial neoplasia, colorectal high-grade intraepithelial neoplasia, invasive colorectal carcinomas and corresponding adjacent tissues.
  • 60.24% (50/83) of colorectal high-grade intraepithelial neoplasia demonstrated immunostaining with KGH-R1, the average percentage of positive cells was 95.08%, the average HSCOREs was 156.38.
  • 64.58% (31/48) of colorectal low-grade intraepithelial neoplasia demonstrated immunoreactivity with KGH-R1, the average percentage of positive cells was 82.52%, the average HSCOREs was 103.03.
  • The the average percentage of positive cells and the average HSCOREs in invasive colorectal carcinomas had no statistical significance with adjacent high-grade intraepithelial neoplasia, but were higher than that in adjacent low-grade intraepithelial neoplasia.
  • [MeSH-major] Antibodies, Monoclonal / immunology. Colorectal Neoplasms / immunology. Proto-Oncogene Proteins p21(ras) / immunology

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  • (PMID = 21138685.001).
  • [ISSN] 1007-8738
  • [Journal-full-title] Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
  • [ISO-abbreviation] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; EC 3.6.5.2 / HRAS protein, human; EC 3.6.5.2 / Proto-Oncogene Proteins p21(ras)
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94. Jung de Campos K, Focchi GR, Martins NV, Góis Speck NM, Baracat EC, Ribalta JC: Angiogenesis in squamous intraepithelial neoplasia of the uterine cervix in HIV-seropositive women. Eur J Gynaecol Oncol; 2005;26(6):615-8
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  • [Title] Angiogenesis in squamous intraepithelial neoplasia of the uterine cervix in HIV-seropositive women.
  • OBJECTIVES: This study aimed to quantify angiogenesis in squamous intraepithelial lesions of the uterine cervix in seropositive HIV patients as well as to establish a relationship between vascular density and variations in the CD4+ lymphocyte titer and the viral load of human immunodeficiency virus (HIV).
  • METHODS: 125 patients, 55 HIV seropositive and 70 seronegative, were allocated with respect to grade of squamous intraepithelial lesion (SIL).
  • RESULTS: Seropositive HIV patients presented a higher mean vascular density (MVD) than the control group, even in the absence of cervical intraepithelial lesions.
  • CONCLUSIONS: Infection with HIV influenced angiogenesis of uterine cervix in the presence of squamous intraepithelial lesions and more significantly in HSIL.
  • [MeSH-major] Carcinoma, Squamous Cell / blood supply. Cervical Intraepithelial Neoplasia / blood supply. Cervix Uteri / blood supply. HIV Seropositivity / complications. Neovascularization, Pathologic. Uterine Cervical Neoplasms / blood supply


95. Mungan MU, Gurel D, Canda AE, Tuna B, Yorukoglu K, Kirkali Z: Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma. Eur Urol; 2006 Jul;50(1):92-7; discussion 97
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  • [Title] Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma.
  • To determine the relationship between cyclooxygenase 2 (COX-2) expression, inflammation, and carcinogenesis in human renal cell carcinoma (RCC), we looked for COX-2 expression in normal and pyelonephritic kidney, renal intratubular neoplasia (RIN), and RCC tissues.
  • [MeSH-major] Carcinoma in Situ / enzymology. Carcinoma, Renal Cell / enzymology. Cyclooxygenase 2 / metabolism. Kidney / enzymology. Kidney Neoplasms / enzymology. Pyelonephritis / enzymology

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  • [CommentIn] Eur Urol. 2006 Jul;50(1):23-5 [16455185.001]
  • (PMID = 16426736.001).
  • [ISSN] 0302-2838
  • [Journal-full-title] European urology
  • [ISO-abbreviation] Eur. Urol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] EC 1.14.99.1 / Cyclooxygenase 2
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96. Lapthanasupkul P, Poomsawat S, Punyasingh J: A clinicopathologic study of oral leukoplakia and erythroplakia in a Thai population. Quintessence Int; 2007 Sep;38(8):e448-55
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  • Microscopic study of leukoplakia revealed hyperkeratosis with or without acanthosis in 60.9% of cases, epithelial dysplasia in 10.6%, and squamous cell carcinoma in 4.9%.
  • Epithelial dysplasia and squamous cell carcinoma were found in 6 patients with erythroplakia (66.7%).
  • [MeSH-major] Carcinoma, Squamous Cell / epidemiology. Erythroplasia / epidemiology. Leukoplakia, Oral / epidemiology. Mouth Neoplasms / epidemiology


97. Takeshima M, Saitoh M, Kusano K, Nagayasu H, Kurashige Y, Malsantha M, Arakawa T, Takuma T, Chiba I, Kaku T, Shibata T, Abiko Y: High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka. J Oral Pathol Med; 2008 Sep;37(8):475-9
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  • In the present study, we investigated the hypermethylation of p14, p15 and p16 in pre-cancerous lesions including epithelial dysplasia and submucous fibrosis.
  • Sixty-four patients were clinically diagnosed with leukoplakia, and histopathologically diagnosed with mild or severe dysplasia.
  • Ten patients were diagnosed with submucous fibrosis without epithelial dysplasia.
  • The frequency of hypermethylation was higher than that of positive staining for p53 mutation except in the case of p16 in mild dysplasia.
  • [MeSH-major] Areca / adverse effects. Cyclin-Dependent Kinase Inhibitor p15 / genetics. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Methylation / genetics. Mouth Neoplasms / pathology. Precancerous Conditions / pathology. Tumor Suppressor Protein p14ARF / genetics

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  • (PMID = 18284544.001).
  • [ISSN] 1600-0714
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p15; 0 / Cyclin-Dependent Kinase Inhibitor p16; 0 / Tumor Suppressor Protein p14ARF; 0 / Tumor Suppressor Protein p53; 56HH86ZVCT / Uracil; 8J337D1HZY / Cytosine
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98. Busmanis I, Ho TH, Tan SB, Khoo KS: p53 and bcl-2 expression in invasive and pre-invasive uterine papillary serous carcinoma and atrophic endometrium. Ann Acad Med Singapore; 2005 Aug;34(7):421-5
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  • INTRODUCTION: Uterine papillary serous carcinoma (UPSC), a high-grade tumour, is known to be associated in some cases with an identifiable intraepithelial neoplasia (IEN) component.
  • [MeSH-major] Cystadenocarcinoma, Papillary / pathology. Endometrium / pathology. Gene Expression Regulation, Neoplastic. Neoplasm Invasiveness / pathology. Precancerous Conditions / pathology. Uterine Neoplasms / pathology

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  • (PMID = 16123814.001).
  • [ISSN] 0304-4602
  • [Journal-full-title] Annals of the Academy of Medicine, Singapore
  • [ISO-abbreviation] Ann. Acad. Med. Singap.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Singapore
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Proto-Oncogene Proteins c-bcl-2
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99. Frable WJ: Error reduction and risk management in cytopathology. Semin Diagn Pathol; 2007 May;24(2):77-88
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  • There are common threads that appear consistently in the analysis of slides from allegedly misdiagnosed cervical cytology cases, including small-cell variants of high-grade squamous intraepithelial neoplasia (HGSIL), present in small numbers; hyperchromatic crowded cell groups; atypical squamous cells of undetermined significance (ASCUS); smears taken during menses; other bloody smears, particularly with degenerative features or excessive inflammation; others showing atypical repair; and unsatisfactory samples.
  • The incidence of cervical cancer in the United States, at only 9700 new cases per year, is low, emphasizing the need for clinical vigilance, attention to unexplained symptoms and signs, and biopsies of any cervical abnormality.

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  • (PMID = 17633349.001).
  • [ISSN] 0740-2570
  • [Journal-full-title] Seminars in diagnostic pathology
  • [ISO-abbreviation] Semin Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Hsue SS, Wang WC, Chen CH, Lin CC, Chen YK, Lin LM: Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital. J Oral Pathol Med; 2007 Jan;36(1):25-9
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  • The aim of this follow-up study was to estimate the rate and the time to transformation in a group of patients from southern Taiwan with potentially malignant oral epithelial lesions.
  • The histological diagnoses were divided into six categories: epithelial dysplasia with hyperkeratosis/epithelial hyperplasia (8.85%); epithelial dysplasia with submucous fibrosis (2.54%); submucous fibrosis (27.57%); hyperkeratosis/epithelial hyperplasia (29.01%); lichen planus (9.80%) and verrucous hyperplasia (22.22%).
  • Eight of the 166 patients with dysplastic lesions and 15 of 423 patients with hyperkeratosis/epithelial hyperplasia progressed to malignancy.
  • [MeSH-major] Cell Transformation, Neoplastic / pathology. Mouth Neoplasms / pathology. Precancerous Conditions / pathology

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  • (PMID = 17181738.001).
  • [ISSN] 0904-2512
  • [Journal-full-title] Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
  • [ISO-abbreviation] J. Oral Pathol. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
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