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1. Zadeh VB, Kadyan R, Al-Abdulrazzaq A, Al-Otaibi S, Sarhan A, Najem N: Sister Mary Joseph's nodule: a case of umbilical cutaneous metastasis with signet ring cell histology. Indian J Dermatol Venereol Leprol; 2009 Sep-Oct;75(5):503-5
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  • [Title] Sister Mary Joseph's nodule: a case of umbilical cutaneous metastasis with signet ring cell histology.
  • The metastasis of a visceral malignancy to the umbilicus is known as "Sister Mary Joseph's nodule".
  • It is a rare clinical sign indicating advanced, metastasizing intraabdominal cancer.
  • We report a 50-year-old man who developed metastatic skin cancer in the form of semicircular indurated plaque on top of which was a firm mobile rounded nodule at the umbilical area.
  • [MeSH-major] Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Umbilicus / pathology

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  • (PMID = 19736432.001).
  • [ISSN] 0973-3922
  • [Journal-full-title] Indian journal of dermatology, venereology and leprology
  • [ISO-abbreviation] Indian J Dermatol Venereol Leprol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
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2. Park JM, Kim DS, Oh SH, Kwon YS, Lee KH: A case of esophageal adenocarcinoma metastasized to the scalp. Ann Dermatol; 2009 May;21(2):164-7

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  • Cutaneous metastases from internal malignancies are, occurring in 0.5% to 9% of cases.
  • Lung, breast, and colorectal cancers are common primary tumors that metastasize to the skin; cutaneous metastasis usually occurs on the chest wall and abdomen as asymptomatic nodular patterns.
  • Esophageal cancer is not nearly as common as breast, lung, and colorectal cancers, and esophageal cancer rarely metastasizes to the skin.
  • Cutaneous metastasis of esophageal cancer is rare and metastasis to the scalp is extremely rare.
  • Only a few cases of cutaneous metastases of esophageal cancer have been reported in Korea.
  • Most of the cases involved cutaneous metastases arising from esophageal squamous cell carcinoma; however, there have been several reports describing cutaneous metastases from esophageal adenocarcinomas.
  • Herein, we describe a case of metastatic skin cancer that originated from esophageal adenocarcinoma.

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  • [Cites] J Gastroenterol Hepatol. 2007 Jun;22(6):908-12 [17565647.001]
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  • (PMID = 20523777.001).
  • [ISSN] 2005-3894
  • [Journal-full-title] Annals of dermatology
  • [ISO-abbreviation] Ann Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2861207
  • [Keywords] NOTNLM ; Adenocarcinoma / Esophagus / Metastasis / Scalp
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3. Triller Vadnal K, Triller N, Pozek I, Kecelj P, Kosnik M: Skin metastases of lung cancer. Acta Dermatovenerol Alp Pannonica Adriat; 2008 Sep;17(3):125-8
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  • [Title] Skin metastases of lung cancer.
  • Skin metastases of lung cancer are rare.
  • In over a 3-year period we found only 14 cases of skin metastases among 1,614 patients with lung cancer admitted to the University Clinic of Respiratory and Allergic Diseases in Golnik.
  • The metastases are usually manifested on the skin of the chest.
  • Skin metastases are symptoms of progressive disease, and usually a sign of a poor prognosis.
  • The median survival time of lung cancer patients with skin metastases was 85 days from the time of detection of the skin lesion.
  • Because skin metastases can be the first sign of the disease, the entire skin should be carefully inspected whenever malignant disease is suspected.
  • [MeSH-major] Carcinoma / secondary. Lung Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 18853075.001).
  • [ISSN] 1318-4458
  • [Journal-full-title] Acta dermatovenerologica Alpina, Pannonica, et Adriatica
  • [ISO-abbreviation] Acta Dermatovenerol Alp Pannonica Adriat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Slovenia
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4. Bhatia K, Vaid AK, Rawal S, Patole KD: Pure choriocarcinoma of testis with rare gingival and skin metastases. Singapore Med J; 2007 Mar;48(3):e77-80
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  • [Title] Pure choriocarcinoma of testis with rare gingival and skin metastases.
  • A 22-year-old man presented with complaints of gingival and skin lesions.
  • Fine-needle aspiration cytology from skin and gingival lesions was suggestive of metastatic deposits.
  • Patient underwent left high orchidectomy, and histopathological examination was consistent with the diagnosis of pure choriocarcinoma.
  • Although rare, cases of testicular neoplasms and especially choriocarcinoma of the testis leading to skin metastases have been reported, but case reports of choriocarcinoma of testis metastatic to gingiva have been reported exceptionally in the English literature.
  • We report this unique case of a young man with pure choricarcinoma of testis with unusual gingival and skin metastases.
  • [MeSH-major] Choriocarcinoma / secondary. Gingival Neoplasms / secondary. Skin Neoplasms / secondary. Testicular Neoplasms / pathology

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  • (PMID = 17342276.001).
  • [ISSN] 0037-5675
  • [Journal-full-title] Singapore medical journal
  • [ISO-abbreviation] Singapore Med J
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Singapore
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5. Ardavanis A, Orphanos G, Ioannidis G, Rigatos G: Skin metastases from primary lung cancer. Report of three cases and a brief review. In Vivo; 2006 Sep-Oct;20(5):671-3
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  • [Title] Skin metastases from primary lung cancer. Report of three cases and a brief review.
  • Skin metastasis from lung cancer is an unusual event carrying an ominous prognosis.
  • Three cases with non-small cell lung cancer (NSCLC) with skin involvement and rapidly fatal clinical course due to extensive CNS metastasis are reported.
  • The eventual association of skin metastases and a phenotype with "CNS-predilection" or an aggressive phase of NSCLC are discussed.
  • [MeSH-major] Adenocarcinoma / pathology. Carcinoma, Squamous Cell / pathology. Lung Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 17091776.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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6. Hanson RP, Kneafsey B, Royston D: Cutaneous lesions, not just skin deep! Ir J Med Sci; 2006 Jan-Mar;175(1):66-8
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  • [Title] Cutaneous lesions, not just skin deep!
  • BACKGROUND: Cutaneous metastatic disease is not unusual but it may mimic inflammatory lesions.
  • The growth pattern of skin metastases is unpredictable and may differ from that of the primary tumour.
  • Skin metastases may present as rapidly growing, solitary sessile or polypoid vascular nodules that ulcerate or bleed.
  • AIM: To investigate the presenting complaints, surgical treatment and outcome of patients with cutaneous metastatic disease.
  • METHODS: We present three cases of metastatic skin cancer recently seen in our Department and review the clinical and pathological findings.
  • RESULTS: The finding of metastatic skin cancer is associated with a very poor prognosis and suggests widespread disease dissemination.
  • CONCLUSION: The paper emphasizes the importance of excisional biopsy and accurate tissue diagnosis of skin nodules.
  • [MeSH-major] Neoplasm Metastasis / diagnosis. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / diagnosis. Adenocarcinoma / secondary. Aged. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma, Renal Cell / pathology. Female. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Lung Neoplasms / pathology. Male. Middle Aged. Uterine Neoplasms / pathology

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  • (PMID = 16615234.001).
  • [ISSN] 0021-1265
  • [Journal-full-title] Irish journal of medical science
  • [ISO-abbreviation] Ir J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Ireland
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7. Basile J, Thiers B, Maize J Sr, Lathers DM: Chemokine receptor expression in non-melanoma skin cancer. J Cutan Pathol; 2008 Jul;35(7):623-9
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  • [Title] Chemokine receptor expression in non-melanoma skin cancer.
  • BACKGROUND: Previous studies suggest that chemokines and chemokine receptors have a role in the metastatic process.
  • A correlation exists between the specific expression of these chemoattractive, pro-inflammatory cytokines and the ability of cancer to disseminate.
  • Prior studies have shown that in metastatic melanoma and squamous cell carcinoma of the head and neck upregulation of CXC (alpha) chemokine receptor (CXCR)4 and CC (beta) chemokine receptor (CCR)7 expression is accompanied by downregulation of the chemokine receptor CCR6.
  • However, the expression patterns of CCR6, CCR7 and CXCR4 in non-melanoma skin cancer have yet to be elucidated.
  • RESULTS: Analysis of chemokine receptor expression showed downregulation of CCR6 and upregulation of CCR7 and CXCR4 in potentially metastatic non-melanoma skin cancer, invasive squamous cell carcinoma, but this pattern did not exist in non-melanoma skin cancer with no metastatic potential, basal cell carcinoma; or actinic keratosis, when compared with normal skin.
  • CONCLUSIONS: Chemokine receptor expression may influence the biological behavior of non-melanoma skin cancer.
  • [MeSH-major] Carcinoma, Basal Cell / metabolism. Carcinoma, Squamous Cell / metabolism. Keratosis / metabolism. Receptors, CCR6 / metabolism. Receptors, CCR7 / metabolism. Receptors, CXCR4 / metabolism. Skin Neoplasms / metabolism
  • [MeSH-minor] Analysis of Variance. Biomarkers / metabolism. Down-Regulation. Humans. Immunohistochemistry. Neoplasm Metastasis / physiopathology. Precancerous Conditions / metabolism. Precancerous Conditions / pathology. Skin / metabolism. Skin / pathology. Staining and Labeling. Ultraviolet Rays / adverse effects. Up-Regulation

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  • (PMID = 18312436.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers; 0 / CCR6 protein, human; 0 / CCR7 protein, human; 0 / CXCR4 protein, human; 0 / Receptors, CCR6; 0 / Receptors, CCR7; 0 / Receptors, CXCR4
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8. Krunic AL, Cockerell CJ, Truelson J, Taylor RS: Laryngeal squamous cell carcinoma with infradiaphragmatic presentation of skin metastases. Clin Exp Dermatol; 2006 Mar;31(2):242-4
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  • [Title] Laryngeal squamous cell carcinoma with infradiaphragmatic presentation of skin metastases.
  • Distant metastases in squamous cell carcinoma of the larynx have an incidence of 6.5-7.2%, and most commonly involve the lungs, liver and bone.
  • Metastases to the skin are exceedingly rare, with only 30 cases reported in the literature.
  • Skin metastases may represent the first clinical evidence of impending locoregional recurrence, suggest distant metastatic spread, or rarely, be the first sign of 'silent' laryngeal tumour.
  • Infradiaphragmatic presentation of metastatic laryngeal squamous cell carcinoma is exceptional, with only four cases reported in the literature.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Laryngeal Neoplasms. Lung Neoplasms / secondary. Skin Neoplasms / secondary

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  • (PMID = 16487102.001).
  • [ISSN] 0307-6938
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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9. Grabiec M, Walentowicz M, Marszałek A: Multiple skin metastases to vulva from carcinoma of the cervical stump. Ginekol Pol; 2010 Feb;81(2):140-3
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  • [Title] Multiple skin metastases to vulva from carcinoma of the cervical stump.
  • Metastases to the skin occur rarely in the cervical carcinoma, even in terminal stage of the disease.
  • The frequency of metastasis is estimated from 0.01% to 2%.
  • The presence of metastasis suggests generalized dissemination of the disease and reflects a rapidly progressive process that appear in the final stage of the disease.
  • CASE: We present a case of skin metastases in patients with squamous cell carcinoma of the cervical stump after the previous supracervical hysterectomy for benign disease of the uterus.
  • The extensive skin changes on vulva and perineum occurred after radical trachelectomy and external radiation therapy.
  • CONCLUSION: As far as we know this is the first case report of squamous cell carcinoma in the cervical stump metastasizing to skin.
  • Skin metastases indicate an aggressive and progressive process.
  • [MeSH-major] Carcinoma, Squamous Cell / etiology. Carcinoma, Squamous Cell / secondary. Hysterectomy / adverse effects. Skin Neoplasms / secondary. Uterine Cervical Neoplasms / etiology. Vulvar Neoplasms / secondary


10. Sigüenza M, Pizarro A, Mayor M, Vidaurrázaga C, Miralles L, González-Beato M, Casado M: [Topical treatment of melanoma skin metastases with imiquimod]. Actas Dermosifiliogr; 2005 Mar;96(2):111-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Topical treatment of melanoma skin metastases with imiquimod].
  • [Transliterated title] Tratamiento tópico de las metástasis cutáneas de melanoma con imiquimod.
  • The treatment of skin metastases of melanoma can be difficult in many cases because of the patients age, as well as the number, size and location of the lesions.
  • We present the case of an 82-year-old male with melanoma skin metastases on the scalp, which responded satisfactorily to treatment with 5 % imiquimod cream.
  • This case, along with others that have recently been published, supports the usefulness of this treatment in selected cases of melanoma skin metastases, at least for palliative purposes.
  • [MeSH-major] Aminoquinolines / administration & dosage. Antineoplastic Agents / administration & dosage. Head and Neck Neoplasms / drug therapy. Head and Neck Neoplasms / secondary. Melanoma / drug therapy. Melanoma / secondary. Scalp. Skin Neoplasms / drug therapy. Skin Neoplasms / secondary

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  • [CommentIn] Actas Dermosifiliogr. 2005 Oct;96(8):549-50 [16476296.001]
  • (PMID = 16476347.001).
  • [ISSN] 0001-7310
  • [Journal-full-title] Actas dermo-sifiliográficas
  • [ISO-abbreviation] Actas Dermosifiliogr
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Chemical-registry-number] 0 / Aminoquinolines; 0 / Antineoplastic Agents; 99011-02-6 / imiquimod
  • [Number-of-references] 16
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11. Molina Garrido MJ, Mora Rufete A, Guillén Ponce C, Maciá Escalante S, Carrato Mena A: Skin metastases as first manifestation of lung cancer. Clin Transl Oncol; 2006 Aug;8(8):616-7
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  • [Title] Skin metastases as first manifestation of lung cancer.
  • Skin metastases as manifestation of internal neoplasias constitute a 0.8% of their initial presentation and generally imply an advanced stage of the disease and a short survival.
  • The lung cancer metastasises to the skin in 2.8-24% of the cases, generally in advanced stages of the disease, although in 7-19%, skin metastases appear as first manifestation thereof.
  • Sometimes, the study of the extent in the patients reveals that there are no metastases at other levels.
  • We hereby present the case of a male diagnosed with a lung cancer whose first manifestation was the appearance of skin metastases.
  • [MeSH-major] Lung Neoplasms / pathology. Skin Neoplasms / secondary

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  • [Cites] Chest. 1994 Nov;106(5):1448-50 [7956399.001]
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  • (PMID = 16952852.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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12. Krunic AL, Chen HM, Lopatka K: Signet-ring cell carcinoma of the gallbladder with skin metastases. Australas J Dermatol; 2007 Aug;48(3):187-9
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  • [Title] Signet-ring cell carcinoma of the gallbladder with skin metastases.
  • Cutaneous metastasis from gallbladder cancer is extremely rare.
  • We present a case of signet-ring cell carcinoma of the gallbladder metastatic to the skin in a 38-year-old man.
  • The skin nodules on the face, scalp and perianal area occurred approximately 1 year after the resection of the neoplasm.
  • Skin metastases from gastrointestinal cancers are usually detected around surgical scars or on the abdominal wall, especially in the periumbilical region, and rarely present at other sites.
  • Multiple imaging studies revealed the presence of metastatic bony involvement in the spine and left orbit.
  • Visceral metastases have not been demonstrated in our patient in 20 months of follow up since the initial diagnosis of gallbladder cancer was made.
  • We also briefly discuss other primary and metastatic skin tumours with signet-ring cell morphology.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Gallbladder Neoplasms / pathology. Skin Neoplasms / secondary


13. Dequanter D, Mboti FB, Lothaire P, Andry G: Skin metastases from a head and neck carcinoma: a prognostic factor? B-ENT; 2005;1(3):113-5
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  • [Title] Skin metastases from a head and neck carcinoma: a prognostic factor?
  • BACKGROUND: Distant metastases in head and neck cancer are often to the lung, and rarely to the skin sites.
  • METHOD: To ascertain that a skin metastasis indicates a poor prognosis, a review was conducted of patients with head and neck cancer.
  • RESULTS: Three out of seven patients had evidence of local recurrence at the time of development of the skin metastases, and three out of seven had evidence of distant metastases.
  • The average survival time was 1 month after the development of skin metastases.
  • CONCLUSION: Skin metastases may represent the first clinical evidence of impending recurrence or distant metastasis.
  • The development of skin metastasis is associated with a poor prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / mortality. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / mortality. Head and Neck Neoplasms / pathology. Skin Neoplasms / mortality. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Female. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate

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  • (PMID = 16255495.001).
  • [ISSN] 1781-782X
  • [Journal-full-title] B-ENT
  • [ISO-abbreviation] B-ENT
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Belgium
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14. Früh M, Ruhstaller T, Neuweiler J, Cerny T: Resection of skin metastases from gastric carcinoma with long-term follow-up: an unusual clinical presentation. Onkologie; 2005 Jan;28(1):38-40
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  • [Title] Resection of skin metastases from gastric carcinoma with long-term follow-up: an unusual clinical presentation.
  • BACKGROUND: Skin metastases from gastric cancer are rare and generally occur at a very late stage in the course of the disease.
  • 6 isolated skin metastases occurred on the head and on the thigh 2 years later.
  • Morphologically and according to an extensive immunohistochemical comparison the skin lesions and the primary tumor were identical.
  • The patient presented with dysphagia more than 6 years after the primary diagnosis, and a local recurrence was diagnosed.
  • This patient remains free of symptoms and is clinically in complete remission 7.5 years after the primary diagnosis.
  • CONCLUSION: We report a long-term disease-free survival of a patient with isolated cutaneous metastases of a gastric cancer.
  • Usually the prognosis after occurrence of metastases to the skin is poor, but long-term survival after systemic therapy has been reported.
  • This patient is clinically in remission more than 5 years after surgical resection of several cutaneous metastases and after successful resection of a local recurrence more than 1 year ago.
  • One should be aware of such unusual clinical courses of a disease, and that the prognosis can deviate significantly from the average when the pattern of metastasis is unusual.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Skin Neoplasms / secondary. Skin Neoplasms / surgery. Stomach Neoplasms / surgery

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  • (PMID = 15604627.001).
  • [ISSN] 0378-584X
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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15. Savoia P, Fava P, Nardò T, Osella-Abate S, Quaglino P, Bernengo MG: Skin metastases of malignant melanoma: a clinical and prognostic survey. Melanoma Res; 2009 Oct;19(5):321-6
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  • [Title] Skin metastases of malignant melanoma: a clinical and prognostic survey.
  • Skin metastases are a frequent event in the natural history of malignant melanoma, both in the early and late phases of disease progression.
  • Statistical analyses were focused on patients with secondary involvement of the skin.
  • Seven hundred and thirty-three of the 4030 patients that met the inclusion criteria (18.2%) developed cutaneous metastases; the skin was involved as first site in 413 patients (56.3%) and after regional lymph node spreading in 208 (28.4%) patients.
  • In a lower number of patients, cutaneous metastases developed only in advanced stages of the disease.
  • Skin metastases were mainly locoregional, when arising as the first site of relapse (89.3%) and/or in patients with a primary melanoma of the lower limbs; in contrast, disseminated metastases are more often observed after a visceral involvement and for primary melanomas of the trunk.
  • Moreover, despite a lower disease-free survival rate (1.3 vs. 2.9 years), we showed a significantly longer time to progression to visceral involvement for the group of patients with cutaneous locoregional metastases (62.5 vs. 17.8 months).
  • The site of primary melanoma is strictly related to the pattern of cutaneous recurrence.
  • The disparity in clinical outcome between patients with locoregional or disseminated skin metastases should therefore be taken into consideration in their management.
  • [MeSH-major] Melanoma / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Disease Progression. Disease-Free Survival. Female. Humans. Italy / epidemiology. Kaplan-Meier Estimate. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Prospective Studies. Risk Factors. Young Adult

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  • (PMID = 19641475.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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16. Gaudy C, Richard MA, Folchetti G, Bonerandi JJ, Grob JJ: Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma. J Cutan Med Surg; 2006 May-Jun;10(3):115-21
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  • [Title] Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma.
  • BACKGROUND: Electrochemotherapy (ECT) combines intralesional injections of bleomycin with electroporation (EP), which permeabilizes tumor cells and thus increases the bleomycin efficacy at the tumor site.
  • OBJECTIVE: To assess whether EP therapy improves the local control of skin metastases of melanoma by intralesional bleomycin.
  • The secondary objective was to evaluate tolerance of the treatments.
  • PATIENTS: Patients with at least two measurable skin metastases of melanoma that were previously untreated, either in stage III with in-transit melanoma skin metastases or stage IV with no efficacy of systemic chemotherapy on these metastases.
  • DESIGN: A prospective internally controlled study with randomization of melanoma skin metastases in each individual to intralesional injections of bleomycin alone or to intralesional injections of bleomycin with EP.
  • The primary end point was the rate of complete local response per treated melanoma skin metastasis at week 12, and the secondary end point was tolerance.
  • RESULTS: Fifty-four melanoma skin metastases were treated in 12 patients (8 stage IV patients under chemotherapy and 4 stage III patients free of other treatment).
  • A local complete response was obtained in 36% (11 of 30) of melanoma skin metastases treated with bleomycin + EP and only in 8% (2 of 24) of melanoma skin metastases treated with bleomycin alone (p = .016).
  • CONCLUSIONS: EP increases the effect of intralesional bleomycin and improves the rate of local control in melanoma skin metastases without inducing a more systemic effect.
  • This local treatment could be useful in a palliative strategy in patients with melanoma skin metastases.
  • [MeSH-major] Antibiotics, Antineoplastic / administration & dosage. Bleomycin / administration & dosage. Electroporation. Melanoma / drug therapy. Skin Neoplasms / drug therapy

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  • (PMID = 17241586.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibiotics, Antineoplastic; 11056-06-7 / Bleomycin
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17. Azoulay S, Adem C, Pelletier FL, Barete S, Francès C, Capron F: Skin metastases from unknown origin: role of immunohistochemistry in the evaluation of cutaneous metastases of carcinoma of unknown origin. J Cutan Pathol; 2005 Sep;32(8):561-6
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  • [Title] Skin metastases from unknown origin: role of immunohistochemistry in the evaluation of cutaneous metastases of carcinoma of unknown origin.
  • Determining the primary origin of skin metastases might be a challenging issue for pathologists, especially when there is no primary history or when this history is unavailable.
  • We have retrieved 44 cases of skin metastases from our pathology files.
  • We have tried to assess the primary origin based on morphological data alone, and then using 13 antibodies (cytokeratins (CK) 5/6, 7, 19, 20, thyroid transcription factor-1, carcinoembryonic antigen, PS100, tumor-associated glycoprotein 72, BerEP4, estrogen receptor (ER), progesterone receptor (PR), CD10, and E-cadherin).
  • Most metastases in our series were from breast (13) and colorectal cancers (six) as they are the main clinical activity in our hospital.
  • CK 20, ER, and PR were the most helpful markers to determine the primary origin of skin metastases by highlighting colorectal origin and mammary origin, respectively.
  • Skin metastases from unknown origin: role of immunohistochemistry in the evaluation of cutaneous metastases of carcinoma of unknown origin.
  • [MeSH-major] Adenocarcinoma / secondary. Immunohistochemistry / methods. Neoplasms, Unknown Primary / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Female. Humans. Tissue Array Analysis

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  • (PMID = 16115055.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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18. Simpson LK, Ostlere LS, Harland C, Gharaie S: Treatment with carbon dioxide laser of painful skin metastases from a laryngeal neuroendocrine carcinoma. Clin Exp Dermatol; 2009 Dec;34(8):e873-5
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  • [Title] Treatment with carbon dioxide laser of painful skin metastases from a laryngeal neuroendocrine carcinoma.
  • An 82-year-old man presented with multiple, exquisitely painful skin metastases from an atypical carcinoid tumour of the larynx.
  • To our knowledge, this is the first reported case of laser treatment used in the management of neuroendocrine skin metastases.
  • [MeSH-major] Carcinoma, Neuroendocrine / surgery. Laryngeal Neoplasms / surgery. Pain / surgery. Skin Neoplasms / surgery

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  • (PMID = 20055852.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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19. Tokugawa T, Kobayashi A, Okubo K, Matsuyama T, Imai S, Koyama H: [A patient with multiple skin metastases from breast cancer responding to S-1 effectively under treatment with trastuzumab]. Gan To Kagaku Ryoho; 2009 Apr;36(4):679-82
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  • [Title] [A patient with multiple skin metastases from breast cancer responding to S-1 effectively under treatment with trastuzumab].
  • We report a case of a 52-year-old female with multiple skin metastases from breast cancer who responded to S-1.
  • Multiple skin metastases were later detected.
  • Thoracic CT at the end of the three courses revealed the disappearance of the multiple skin metastases.
  • It was concluded from these findings that S-1 could be safely and effectively administered to advanced breast cancer patients.
  • [MeSH-major] Antibodies, Monoclonal / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Oxonic Acid / therapeutic use. Skin Neoplasms / drug therapy. Skin Neoplasms / secondary. Tegafur / therapeutic use
  • [MeSH-minor] Antibodies, Monoclonal, Humanized. Biomarkers, Tumor / blood. Disease Progression. Drug Combinations. Female. Humans. Immunotherapy. Middle Aged. Tomography, X-Ray Computed. Trastuzumab

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  • (PMID = 19381048.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Biomarkers, Tumor; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; P188ANX8CK / Trastuzumab
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20. Gholam D, Chebib A, Hauteville D, Bralet MP, Jasmin C: Combined paclitaxel and cetuximab achieved a major response on the skin metastases of a patient with epidermal growth factor receptor-positive, estrogen receptor-negative, progesterone receptor-negative and human epidermal growth factor receptor-2-negative (triple-negative) breast cancer. Anticancer Drugs; 2007 Aug;18(7):835-7
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  • [Title] Combined paclitaxel and cetuximab achieved a major response on the skin metastases of a patient with epidermal growth factor receptor-positive, estrogen receptor-negative, progesterone receptor-negative and human epidermal growth factor receptor-2-negative (triple-negative) breast cancer.
  • Cetuximab competes with ligand binding to the epidermal growth factor receptor ectodomain, resulting in an efficient blockade of tumor-promoting downstream signaling pathways.
  • Studies in human breast cancer xenografts showed cetuximab synergy with paclitaxel, a potent mitosis spindle-cell stabilizer.
  • In this report, combined paclitaxel and cetuximab achieved a major reduction of the skin metastases of a heavily pretreated patient with epidermal growth factor receptor-positive, estrogen receptor-negative, progesterone receptor-negative and human epidermal growth factor receptor-2-negative (triple-negative) invasive ductal breast carcinoma.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Breast Neoplasms / drug therapy. Carcinoma, Ductal, Breast / drug therapy. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Skin Neoplasms / drug therapy
  • [MeSH-minor] Acneiform Eruptions / chemically induced. Antibodies, Monoclonal / administration & dosage. Antibodies, Monoclonal / adverse effects. Antibodies, Monoclonal, Humanized. Cetuximab. Female. Humans. Middle Aged. Neoplasm Invasiveness. Paclitaxel / administration & dosage. Paclitaxel / adverse effects. Receptor, ErbB-2 / analysis. Receptors, Estrogen / analysis. Receptors, Progesterone / analysis. Severity of Illness Index. Treatment Outcome


21. Yildirim Y, Akcay Y, Ozyilkan O, Celasun B: Prostate small cell carcinoma and skin metastases: a rare entity. Med Princ Pract; 2008;17(3):250-2
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  • [Title] Prostate small cell carcinoma and skin metastases: a rare entity.
  • OBJECTIVES: To report a rare case of small cell carcinoma of the prostate with unusual skin metastasis.
  • During the follow-up, papillary lesions were observed in the scrotal skin; biopsy showed metastatic small cell carcinoma.
  • CONCLUSION: Small cell carcinoma of the prostate is an aggressive disease with a highly metastatic potential; but skin metastases are very uncommon.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Small Cell / secondary. Prostatic Neoplasms / pathology. Skin Neoplasms / secondary

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  • [Copyright] (c) 2008 S. Karger AG, Basel
  • (PMID = 18408396.001).
  • [ISSN] 1423-0151
  • [Journal-full-title] Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • [ISO-abbreviation] Med Princ Pract
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
  • [Chemical-registry-number] 5J49Q6B70F / Vincristine; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; 8N3DW7272P / Cyclophosphamide; Q20Q21Q62J / Cisplatin
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22. de Haas ER, Nijsten T, de Vries E: Population education in preventing skin cancer: from childhood to adulthood. J Drugs Dermatol; 2010 Feb;9(2):112-6
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  • [Title] Population education in preventing skin cancer: from childhood to adulthood.
  • Skin cancer is the most commonly diagnosed cancer in populations of predominantly Caucasian origins.
  • As the main cause of skin cancer is excessive sun exposure among a sun-sensitive population, most skin cancers are theoretically avoidable, and prevention is an important topic for public health purposes.
  • The development of skin cancer may be limited by effective primary prevention campaigns, causing people to protect themselves from the sun.
  • Secondary skin cancer prevention aims to avoid skin cancer morbidity and mortality and is, therefore, mainly aimed at early detection of cutaneous melanomas.
  • Around the world, elderly men are the worst off in terms of melanoma mortality statistics and would be an important target group for secondary prevention.
  • Several prevention initiatives have been developed, including awareness campaigns and voluntary skin cancer screening days.
  • So far, few of these initiatives have proven to be successful in changing population behavior and/or skin cancer related mortality.
  • In this review, various aspects of primary and secondary skin cancer prevention are discussed, including the results of some of the primary and secondary prevention initiatives.
  • [MeSH-major] Health Education. Skin Neoplasms / prevention & control

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  • (PMID = 20214171.001).
  • [ISSN] 1545-9616
  • [Journal-full-title] Journal of drugs in dermatology : JDD
  • [ISO-abbreviation] J Drugs Dermatol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 43
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23. Rehberger P, Eppinger S, Stein A, Schmitt J: [Therapy of cutaneous metastases of malignant melanoma]. Hautarzt; 2006 Dec;57(12):1143-51; quiz 1152-3
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  • [Title] [Therapy of cutaneous metastases of malignant melanoma].
  • [Transliterated title] Therapie von Hautmetastasen beim malignen Melanom.
  • Malignant melanoma represents a particular challenge for dermatologists and oncologists because of its high and increasing incidence and the poor prognosis of patients with thick primary tumors (T3, T4).
  • In advanced stages of melanoma, cutaneous and subcutaneous metastases have a special significance, as they markedly affect the patient and may lead to a limitation in quality of life.
  • The location, number, size and distribution of skin metastases, involvement of internal organs, age and general condition should be considered in assessing therapeutic options.
  • Especially with solitary, easily accessible metastases, surgical excision represents the therapy of choice.
  • With extensive metastases in just one extremity, isolated limb perfusion (ILP) with melphalan is an option, while multiple, smaller metastases can be irradiated.
  • [MeSH-major] Laser Therapy / methods. Melanoma / secondary. Melanoma / therapy. Melphalan / administration & dosage. Radiotherapy / methods. Skin Neoplasms / secondary. Skin Neoplasms / therapy

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  • (PMID = 17103199.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Alkylating; Q41OR9510P / Melphalan
  • [Number-of-references] 46
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24. Ciocca O, Vassallo C, Brazzelli V, Fiandrino G, Rosso R, Borroni G: Sporotrichoid metastases to the skin from cutaneous squamous cell carcinoma in an immunocompetent patient. Am J Dermatopathol; 2010 Jun;32(4):395-7
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  • [Title] Sporotrichoid metastases to the skin from cutaneous squamous cell carcinoma in an immunocompetent patient.
  • Squamous cell carcinoma (SCC) of the skin may metastasize in more than 5% of cases.
  • Metastases usually involve the primary regional lymph nodes in 85% of cases.
  • The skin is rarely involved by metastases of SCC of the skin.
  • The presence of multiple cutaneous metastases in a figurate array is a very rare occurrence, mostly reported in SCC occurring in immunocompromized patients.
  • Histopathologic examination from the 3 nodules revealed SCC of variable grading, with focal fusion of the metastases with the overlying epidermis.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Antineoplastic Agents, Phytogenic / therapeutic use. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Arm / pathology. Cisplatin / administration & dosage. Fatal Outcome. Fluorouracil / administration & dosage. Hand / pathology. Humans. Immunohistochemistry. Lymphatic Metastasis. Male. Paclitaxel / therapeutic use. Radiotherapy

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  • (PMID = 20495388.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents, Phytogenic; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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25. Stanko C, Grandinetti L, Baldassano M, Mahmoodi M, Kantor GR: Epidermotropic metastatic prostate carcinoma presenting as an umbilical nodule-Sister Mary Joseph nodule. Am J Dermatopathol; 2007 Jun;29(3):290-2
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  • [Title] Epidermotropic metastatic prostate carcinoma presenting as an umbilical nodule-Sister Mary Joseph nodule.
  • Carcinoma of the prostate accounts for fewer than 1% of all skin metastases.
  • Cutaneous metastases from prostate carcinoma most often involve the penis, the anterior aspect of the thighs, the suprapubic area, and the perineum, but they also have been reported in the scalp, the chest, the back, and even the face.
  • We report an unusual case of metastatic prostate adenocarcinoma that presented as an umbilical nodule (Sister Mary Joseph nodule) and demonstrated significant epidermotropism histologically.
  • A review of the literature has found only one documented case of prostatic carcinoma metastasizing to the umbilicus, and one other documented case of epidermotropic metastatic prostate carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Prostatic Neoplasms / pathology. Skin Neoplasms / secondary. Umbilicus / pathology

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  • (PMID = 17519629.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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26. Paradela S, Castiñeiras I, Cuevas J, Almagro M, del Pozo J, Fonseca E: Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40. Am J Dermatopathol; 2008 Oct;30(5):504-8
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  • [Title] Mucinous carcinoma of the skin: evaluation of lymphatic invasion with D2-40.
  • Primary cutaneous mucinous carcinoma is a rare adnexal sweat gland neoplasm that mainly affects elderly people.
  • Differential diagnosis includes mammary and gastrointestinal metastatic mucinous carcinoma (MC) and secondary cutaneous involvement by underlying neoplasms.
  • She underwent partial excision of the tumor and local radiotherapy.
  • Imaging studies showed widespread cutaneous dissemination with enlargement of ipsilateral axillary lymph nodes but without evidence of underlying breast cancer.
  • A diagnosis of primary cutaneous mucinous carcinoma was made.
  • Our aim was to reevaluate the differential clinical, histopathological, and immunohistochemical criteria for distinguishing primary cutaneous mucinous carcinoma from skin metastases of visceral mucinous carcinoma, especially those arising in breast.
  • We also propose D2-40 as a reliable marker to detect lymphatic invasion that indicates a strong aggressive trend with shorter recurrence-free and predicts nodal metastases.
  • [MeSH-major] Adenocarcinoma, Mucinous / diagnosis. Adenocarcinoma, Mucinous / pathology. Skin Neoplasms / diagnosis. Skin Neoplasms / pathology
  • [MeSH-minor] Aged, 80 and over. Antibodies, Monoclonal / metabolism. Antibodies, Monoclonal, Murine-Derived. Biomarkers, Tumor / metabolism. Breast Neoplasms / diagnosis. Breast Neoplasms / metabolism. Breast Neoplasms / pathology. Diagnosis, Differential. Female. Humans. Lymphatic Metastasis

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  • (PMID = 18806501.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Murine-Derived; 0 / Biomarkers, Tumor; 0 / monoclonal antibody D2-40
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27. Choi WJ, Lee YY, Kim S, Kim YK, Kim ES, Seo SO, Jo JH, Lee SM, Lee HJ: A case of medullary thyroid carcinoma in which the skin metastasis was concurrently present and response occurred to chemotherapy. Cancer Res Treat; 2008 Dec;40(4):202-6

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A case of medullary thyroid carcinoma in which the skin metastasis was concurrently present and response occurred to chemotherapy.
  • It rarely metastasizes to skin, and only a few such cases have been documented.
  • Cutaneous metastasis suggests a poor prognosis, with a mean survival of 7.5-19 months.
  • The most effective treatment for skin metastasis is complete surgical removal of all local and regional lesions.
  • We report a case of medullary thyroid carcinoma with cutaneous metastases, which responded to chemotherapy.

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  • [Cites] J Am Acad Dermatol. 1997 Apr;36(4):531-7 [9092737.001]
  • [Cites] J Cutan Pathol. 1987 Aug;14(4):251-4 [3305613.001]
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  • (PMID = 19688131.001).
  • [ISSN] 1598-2998
  • [Journal-full-title] Cancer research and treatment : official journal of Korean Cancer Association
  • [ISO-abbreviation] Cancer Res Treat
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2697479
  • [Keywords] NOTNLM ; Chemotherapy / Cutaneous metastases / Medullary thyroid carcinoma
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28. Loynachan AT, Bolin DC, Hong CB, Poonacha KB: Three equine cases of mixed hepatoblastoma with teratoid features. Vet Pathol; 2007 Mar;44(2):211-4
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  • Case #2 was observed in a neonate with a primary hepatic mass and multiple metastases in the skin, brain, meninges, and stylohyoid bone.

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  • [CommentIn] Vet Pathol. 2010 Sep;47(5):1003-4; author reply 1005-6 [20807828.001]
  • (PMID = 17317799.001).
  • [ISSN] 0300-9858
  • [Journal-full-title] Veterinary pathology
  • [ISO-abbreviation] Vet. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Yang HI, Lee MC, Kuo TT, Hong HS: Cellulitis-like cutaneous metastasis of uterine cervical carcinoma. J Am Acad Dermatol; 2007 Feb;56(2 Suppl):S26-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cellulitis-like cutaneous metastasis of uterine cervical carcinoma.
  • Metastasis to the skin from cervical carcinoma is relatively uncommon.
  • A skin biopsy specimen revealed widespread intravascular tumor emboli in the dermis and subcutis, resembling the so-called inflammatory carcinoma of the breast.
  • As this is an unusual clinical presentation for the metastasis of cervical carcinoma, this case is reported.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Cellulitis / pathology. Head and Neck Neoplasms / pathology. Head and Neck Neoplasms / secondary. Skin Neoplasms / pathology. Skin Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


30. Segawa N, Kotake Y, Hamada S, Takahara K, Azuma H, Katsuoka Y, Tsuji M: [Bladder cancer with skin metastasis: a case report]. Hinyokika Kiyo; 2006 Sep;52(9):711-4
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  • [Title] [Bladder cancer with skin metastasis: a case report].
  • Bladder carcinoma with skin metastasis is extremely rare.
  • We herein report a case of a bladder tumor with skin metastasis.
  • Cystoscopy revealed a trigone papillary tumor.
  • Transurethral resection of bladder tumor (TURBT) was performed and the pathological diagnosis was transitional cell carcinoma (TCC), pT1, G3.
  • Histological examination revealed muscle-invasive bladder cancer with a staging of T3bNOM0.
  • Two years and three months later, multiple firm nodules with eruptions appeared on the skin in several regions; they were resected and the histological findings revealed TCC.
  • This indicated metastatic spread from the primary bladder TCC.
  • He died four months after the manifestation of the skin metastasis due to multiple metastases.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Transitional Cell / secondary. Skin Neoplasms / secondary. Urinary Bladder Neoplasms / pathology

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  • (PMID = 17040057.001).
  • [ISSN] 0018-1994
  • [Journal-full-title] Hinyokika kiyo. Acta urologica Japonica
  • [ISO-abbreviation] Hinyokika Kiyo
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 50SG953SK6 / Mitomycin; 80168379AG / Doxorubicin; D58G680W0G / pirarubicin; Q20Q21Q62J / Cisplatin; YL5FZ2Y5U1 / Methotrexate
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31. Ozeki J, Enomoto K, Sakurai K, Amano S: [A case of the breast cancer metastases to skin treated with local radiotherapy was effective]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2763-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of the breast cancer metastases to skin treated with local radiotherapy was effective].
  • We detected a precordial tumor by palpation in January 2007.
  • She then came to see us as the tumor had grown enlarged.
  • In local findings, the precordium midline showed a non-elastic tumor of 2 cm in size.
  • Biopsy revealed a possibility of breast cancer metastases.
  • The diagnosis was latent breast metastasis.
  • After 2 years from the radiotherapy, there was no recurrence or metastases confirmed until today.
  • In a breast cancer treatment, radiotherapy will be performed for the purpose of local control.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / radiotherapy. Breast Neoplasms / pathology. Breast Neoplasms / radiotherapy. Skin Neoplasms / secondary

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  • (PMID = 21224705.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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32. West KL, Selim MA, Puri PK: Cutaneous metastatic cholangiocarcinoma: a report of three cases and review of the literature. J Cutan Pathol; 2010 Dec;37(12):1230-6
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  • [Title] Cutaneous metastatic cholangiocarcinoma: a report of three cases and review of the literature.
  • Cutaneous metastasis from cholangiocarcinoma is an extremely rare event.
  • Case 1 is that of a young female with scalp metastasis.
  • Cases 2 and 3 involve cutaneous metastasis to the sites of prior biliary drains, one occurring in a young female with a history of multiple biliary surgeries and one in a male with a history of sclerosing cholangitis.
  • Review of the literature shows that the presentation of cutaneous metastases from cholangiocarcinoma can vary in terms of anatomic location and clinical features.
  • The pathological and immunohistochemical profile of metastatic cholangiocarcinoma can be non-specific, and accurate diagnosis relies in part on clinical correlation.
  • In summary, metastatic disease should always be included in the differential diagnosis of cutaneous lesions in patients with known malignancy.
  • [MeSH-major] Neoplasm Recurrence, Local. Skin Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Carcinoma / pathology. Carcinoma / therapy. Female. Humans. Maxillary Sinus Neoplasms / pathology. Maxillary Sinus Neoplasms / therapy. Middle Aged. Neoplasm Metastasis. Time Factors

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  • [Copyright] Copyright © 2010 John Wiley & Sons A/S.
  • (PMID = 20883451.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] Sinonasal undifferentiated carcinoma
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33. Agrawal A, Yau A, Magliocco A, Chu P: Cutaneous metastatic disease in cervical cancer: a case report. J Obstet Gynaecol Can; 2010 May;32(5):467-472
International Agency for Research on Cancer - Screening Group. diagnostics - Histopathology and cytopathology of the uterine cervix - digital atlas .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous metastatic disease in cervical cancer: a case report.
  • BACKGROUND: Cervical cancer metastasizes to skin in < 2% of patients.
  • Cutaneous metastases can be confused with dermatitis.
  • CASE: A 66-year-old postmenopausal woman with a diagnosis of stage IVa cervical carcinoma was treated with radical concurrent chemotherapy and radiation.
  • Two months after completing treatment, the patient noted maculopapular skin lesions in the lower abdomen.
  • These were confirmed on biopsy as metastases from the cervical cancer.
  • The cutaneous metastases progressed rapidly to involve the inguinal regions, vulva, and perineum.
  • Further assessment ruled out metastases to other organs.
  • Despite six courses of palliative combination chemotherapy, the patient's disease progressed, and she died six months after the appearance of the cutaneous metastases.
  • CONCLUSION: We reviewed the details of 47 reported cases of cutaneous metastases of cervical carcinoma.
  • In the majority of these cases, patients presented within 10 years of initial diagnosis and died within a mean of 8.5 months from cutaneous metastasis.
  • [MeSH-major] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Skin Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


34. Bjurlin MA, Bhalani V, Jordan MD, Hollowell CM: Solitary facial cutaneous metastasis as the primary presentation of a small renal cell carcinoma. Urology; 2010 Dec;76(6):1377-8
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  • [Title] Solitary facial cutaneous metastasis as the primary presentation of a small renal cell carcinoma.
  • Cutaneous facial lesions as the primary presentation of RCC is, however, extremely rare.
  • We present clinical, radiographic, and histologic images of a 40-year-old man who presented with a cutaneous facial lesion that was diagnosed as metastatic RCC after excisional biopsy.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Facial Neoplasms / secondary. Kidney Neoplasms / diagnosis. Tomography, X-Ray Computed

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  • [Copyright] Copyright © 2010 Elsevier Inc. All rights reserved.
  • (PMID = 20206972.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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35. Pierret L, Baren NV, Bonehill A, Corthals J, Van Nuffel AM, Heirman C, Roelandt T, De Coninck A, Riet IV, Degreef E, Goossens A, Verfaillie G, Roseeuw D, Thielemans K, Neyns B: Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases. Melanoma Res; 2009 Dec;19(6):385-90
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  • [Title] Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases.
  • Melanoma metastases are characterized by pronounced neo-angiogenesis and spontaneous bleeding frequently occurring within central nervous system metastases.
  • Clinically apparent spontaneous hemorrhage within subcutaneous melanoma metastases, however, is a rare event that coincides with progression of such metastases.
  • We report, to our knowledge the first observation, on regression of subcutaneous metastases with hemorrhage of the overlying skin in three patients with stage IV melanoma who participated in clinical trials on therapeutic vaccination.
  • In two patients, loss of arterial flow on Doppler ultrasound imaging was documented in the metastasis at the time of hematoma formation.
  • One patient suffered from an intracranial hemorrhage in a subcentimetric brain metastasis coincident with the hemorrhagic regression of some of his skin metastases.
  • [MeSH-major] Cancer Vaccines / therapeutic use. Central Nervous System Neoplasms / secondary. Hemorrhage / complications. Melanoma / secondary
  • [MeSH-minor] Adult. Disease Progression. Female. Humans. Intracranial Hemorrhages / etiology. Male. Middle Aged. Neovascularization, Pathologic. Skin Neoplasms / blood supply. Skin Neoplasms / pathology. Skin Neoplasms / therapy. Vaccination

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  • (PMID = 19707165.001).
  • [ISSN] 1473-5636
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cancer Vaccines
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36. Zhang P, Wang Y, Zhang XD, Hu XP, Wang W, Zhang Y, Yin H: [Clinical character of renal transplant recipients with bilateral native upper urinary transitional cell carcinoma]. Zhonghua Yi Xue Za Zhi; 2009 Feb 3;89(4):248-50
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  • RESULTS: The mean time between RTx and diagnosis of TCC was 49.7 months (24 - 96 months).
  • The TCC pathological grades include G(1)-G(2) (n = 7), G3 (n = 6), and cancer in situ (n = 1).
  • Each patient underwent more then 2 times of transurethral resection of bladder tumor (TUR-Bt).
  • Metastasis was found in skin, soft tissue, and costal bone of lumbar in one patient.

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  • (PMID = 19552841.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Immunosuppressive Agents
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37. Schulz V, Kozell K, Biondo PD, Stiles C, Martins L, Tonkin K, Hagen NA: The malignant wound assessment tool: a validation study using a Delphi approach. Palliat Med; 2009 Apr;23(3):266-73
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  • [Title] The malignant wound assessment tool: a validation study using a Delphi approach.
  • Malignant wounds, caused by the direct invasion of cancer into the skin, occur in cancer patients with primary skin tumours and as cutaneous metastasis in approximately 10% of patients with metastatic internal malignancies.
  • Malignant wounds have a profound impact on patients, family members and health care providers.
  • The assessment of the patient with malignant wounds can be complex and there is no widely accepted, consistent approach.
  • Valid, descriptive survey research methods were used to develop the Malignant Wound Assessment Tool (MWAT).
  • An international panel of professionals with clinical or research expertise related to malignant wounds was formed.
  • [MeSH-major] Delphi Technique. Palliative Care. Research Design. Skin Neoplasms / pathology. Wounds and Injuries / pathology

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  • [ErratumIn] Palliat Med. 2009 Jul;23(5):476. Martins, L [added]
  • (PMID = 19318462.001).
  • [ISSN] 1477-030X
  • [Journal-full-title] Palliative medicine
  • [ISO-abbreviation] Palliat Med
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Validation Studies
  • [Publication-country] England
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38. Ch'ng S, Low I, Ng D, Brasch H, Sullivan M, Davis P, Tan ST: Epidermal growth factor receptor: a novel biomarker for aggressive head and neck cutaneous squamous cell carcinoma. Hum Pathol; 2008 Mar;39(3):344-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Epidermal growth factor receptor: a novel biomarker for aggressive head and neck cutaneous squamous cell carcinoma.
  • There is currently no prognostic tool that reliably predicts the risk of metastasis in cutaneous squamous cell carcinoma, most of which occur in the head and neck region.
  • We investigate the role of epidermal growth factor receptor as a biomarker for head and neck cutaneous squamous cell carcinoma.
  • Using immunohistochemistry and fluorescence in situ hybridization, we assessed the epidermal growth factor receptor protein expression and gene copy in 3 groups of head and neck cutaneous squamous cell carcinoma: primary lesions not associated with metastasis (P), primary lesions associated with subsequent metastasis (PM), and metastatic nodal disease (M).
  • Epidermal growth factor receptor overexpression was significantly associated with PM (P = .03) and was found to be an independent prognostic factor for metastasis on multivariate analysis (P = .05).
  • These observations may have important prognostic and therapeutic implications for head and neck cutaneous squamous cell carcinoma.
  • [MeSH-major] Biomarkers, Tumor / analysis. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / pathology. Head and Neck Neoplasms / metabolism. Receptor, Epidermal Growth Factor / biosynthesis. Skin Neoplasms / metabolism

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  • [CommentIn] Hum Pathol. 2009 Jun;40(6):902-3 [19269011.001]
  • (PMID = 18045646.001).
  • [ISSN] 0046-8177
  • [Journal-full-title] Human pathology
  • [ISO-abbreviation] Hum. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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39. Ai-Ping F, Yue Q, Yan W: A case report of remote cutaneous metastasis from male breast carcinoma. Int J Dermatol; 2007 Jul;46(7):738-9
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  • [Title] A case report of remote cutaneous metastasis from male breast carcinoma.
  • He had no other complaints and denied any family history of breast cancer.
  • After biopsy of the skin lesion in our hospital, a breast mass was found, followed by lumpectomy for pathologic examination.
  • The skin and nipple overlying the breast mass were normal.
  • The skin biopsy from the erythema of the left thigh revealed metastatic carcinoma (atypical cells in the lymphatic vessel).
  • The cutaneous metastasis was positive for CK but negative for PR, ER, PS2, and c-erbB-2.
  • [MeSH-major] Breast Neoplasms, Male / pathology. Carcinoma, Intraductal, Noninfiltrating / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Diagnosis, Differential. Edema / etiology. Erythema / etiology. Humans. Lower Extremity / pathology. Lymphatic Metastasis. Male. Tomography, X-Ray Computed


40. Gül U, Kiliç A, Gönül M, Külcü Cakmak S, Erinçkan C: Spectrum of cutaneous metastases in 1287 cases of internal malignancies: a study from Turkey. Acta Derm Venereol; 2007;87(2):160-2
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Spectrum of cutaneous metastases in 1287 cases of internal malignancies: a study from Turkey.
  • Cutaneous metastases may be either the initial manifestation of an internal malignancy or represent recurrent neoplastic disease.
  • The aim of this study was to investigate the incidence and characteristics of cutaneous metastases in cases of internal malignancy.
  • Skin biopsies were obtained from the suspected lesions.
  • The type of malignancy, the time of diagnosis of the malignancy, the presence of cutaneous metastasis, and the localization sites of the cutaneous malignancy were noted.
  • Metastases of any kind were seen in 27.4% of cases.
  • Cutaneous metastases were seen in 1.2% of cases and were most frequently localized on the anterior chest as nodules.
  • Cutaneous metastasis was the first sign of internal malignancy in one case.
  • It is concluded that cutaneous metastases occur rarely and the presentation of internal malignancy with skin involvement is uncommon.
  • [MeSH-major] Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 17340025.001).
  • [ISSN] 0001-5555
  • [Journal-full-title] Acta dermato-venereologica
  • [ISO-abbreviation] Acta Derm. Venereol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Norway
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41. Kato N, Tamura A, Yamanaka Y, Tanimura S, Minakawa H: Malignant blue nevus: case report of a Japanese man with a distant cutaneous metastasis. Am J Dermatopathol; 2007 Feb;29(1):88-91
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  • [Title] Malignant blue nevus: case report of a Japanese man with a distant cutaneous metastasis.
  • We report a 55-year-old Japanese patient with a malignant blue nevus (MBN) on the scalp.
  • The patient had regional lymph nodes metastases at his first visit, and a distant cutaneous metastatic papule appeared on the back 1 year later despite therapeutic intervention.
  • Histology of the primary tumor lacked a junctional component and showed a typically biphasic pattern in the degree of pigmentation similar to a cellular blue nevus (BN).
  • Histology of metastatic regional lymph nodes also showed a biphasic proliferative pattern of oval-shaped, pale cells and spindle-shaped, richly pigmented cells.
  • A distant cutaneous metastatic papule on the back showed massive proliferation of atypically large, pale, and oval-shaped melanoma cells with heavily pigmented melanophages just beneath the uninvolved epidermis.
  • These histologic features were different from those of metastatic tumor proliferation from conventional melanoma.
  • It seems probable that MBN might maintain a different biological and histopathologic character from conventional melanoma when it grows in metastatic sites.
  • [MeSH-major] Nevus, Blue / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Cell Proliferation. Humans. Lymphatic Metastasis. Male. Middle Aged. Scalp / pathology. Skin / pathology

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  • (PMID = 17284970.001).
  • [ISSN] 0193-1091
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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42. Kurul S, Aykan F, Tas F: Penile metastasis of cutaneous malignant melanoma: a true hematogenous spread?: Case report and review of the literature. Melanoma Res; 2006 Jun;16(3):259-61
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Penile metastasis of cutaneous malignant melanoma: a true hematogenous spread?: Case report and review of the literature.
  • Penile involvement has been implicated as a metastatic site in several tumors; approximately 300 cases have been reported.
  • Of these, only two cases showed cutaneous melanoma as the primary site.
  • Our patient presented with a painless mass on the penile shaft together with other distant metastases.
  • [MeSH-major] Melanoma / secondary. Penile Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 16718273.001).
  • [ISSN] 0960-8931
  • [Journal-full-title] Melanoma research
  • [ISO-abbreviation] Melanoma Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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43. Lee HL, Sohn JH, Kim JB, Han DS, Jeon YC, Hahm JS, Lee DH, Kee CS, Park YW: [A case of primary hepatic leiomyosarcoma presenting with multiple subcutaneous scalp mass]. Korean J Gastroenterol; 2005 Sep;46(3):233-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Leiomyosarcoma is an uncommon tumor which arises from various sites including uterus, stomach, retroperitoneum, superficial soft tissues, bladder, kidney, and lung.
  • Primary hepatic leiomyosarcoma is a very rare tumor and fewer than 70 cases of primary hepatic leiomyosarcoma have been reported since the first publication in Japan.
  • And there was only one case report of cutaneous metastasis from hepatic leiomyosarcoma.
  • [MeSH-major] Head and Neck Neoplasms / secondary. Leiomyosarcoma / secondary. Liver Neoplasms / pathology. Scalp. Skin Neoplasms / secondary

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  • (PMID = 16179844.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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44. van der Merwe A, Zarrabi A, Basson J, Stander J, Heyns CF: Distant cutaneous metastases secondary to squamous carcinoma of the penis. Can J Urol; 2009 Feb;16(1):4498-501; discussion 4501
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  • [Title] Distant cutaneous metastases secondary to squamous carcinoma of the penis.
  • Penile cancer normally spreads in a predictable manner to the regional lymph nodes: first inguinal and then the pelvic nodes.
  • We report a case where the patient presented synchronously with secondary skin metastases and primary high grade penile squamous carcinoma.
  • In addition the patient also had pulmonary metastases, loco regional spread to the groin nodes, liver metastases and tumour erosion of a right sided rib.
  • The skin metastases appeared nodular, were firm in consistency and appeared intradermal.
  • Skin metastases have been described for a number of solid malignancies - the clinician must have an index of suspicion to relate a less obvious primary lesion with secondary skin lesions.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Penile Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 19222890.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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45. Lee WJ, Lee DW, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK: Cutaneous metastasis of extraskeletal osteosarcoma arising in the mediastinum. Am J Dermatopathol; 2008 Dec;30(6):629-31
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  • [Title] Cutaneous metastasis of extraskeletal osteosarcoma arising in the mediastinum.
  • Cutaneous metastases have been reported in 5%-10% of patients with internal malignancy.
  • The most frequent metastatic site of extraskeletal osteosarcoma (ESOS) is the lungs.
  • Cutaneous metastasis of ESOS is rare.
  • To our knowledge, only one case of ESOS has been reported with skin metastasis, histopathologically classified as the osteoblastic subtype.
  • Here, we describe a case of chondroblastic ESOS arising in the mediastinum with metastasis to the skin.
  • Our patient presented with a scalp nodule after diagnosis of primary ESOS at the mediastinum.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Osteosarcoma / diagnosis. Osteosarcoma / secondary. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary

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  • (PMID = 19033945.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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46. He DQ, Hua CG, Tang XF, Feng Y: Cutaneous metastasis from a parotid myoepithelial carcinoma: a case report and review of the literature. J Cutan Pathol; 2008 Dec;35(12):1138-43
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  • [Title] Cutaneous metastasis from a parotid myoepithelial carcinoma: a case report and review of the literature.
  • Myoepithelial carcinoma of the parotid gland is a rare salivary gland tumour, and its distant cutaneous metastasis has not been reported to date.
  • Here, we report a case of myoepithelial carcinoma of the left parotid gland, which had metastasised to the skin of the right thorax after parotidectomy and radiotherapy.
  • Diagnosis of the primary and metastatic tumour was based on the clinical findings and was confirmed by immunohistochemistry.
  • A literature review of the clinical features of the skin metastases of parotid malignancies and their related pathological mechanisms is included in this case study.
  • It was noted that myoepithelial carcinoma of the parotid gland has the potential to develop distant skin metastasis, which may be indicative of widespread dissemination and poor prognosis.
  • Attention should be paid to initial treatment of the primary tumour and to emerging cutaneous masses whose location is distant from the primary tumour during follow up.
  • [MeSH-major] Carcinoma / secondary. Parotid Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 18988317.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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47. Kilickap S, Aksoy S, Dinçer M, Saglam EA, Yalçin S: Cutaneous metastases of signet cell carcinoma of the rectum without accompanying visceral involvement. South Med J; 2006 Oct;99(10):1137-9
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  • [Title] Cutaneous metastases of signet cell carcinoma of the rectum without accompanying visceral involvement.
  • Cutaneous metastasis of rectal carcinoma is a rare event.
  • It occurs in fewer than 4% of all patients with rectal cancer.
  • Although skin metastasis of rectal cancer is usually detected around surgical scars or on the abdominal wall, especially in the periumbilical region, it rarely presents at other sites.
  • The early diagnosis of skin metastases in these patients is very important because it can alter treatment.
  • A case of signet cell carcinoma of the rectum with cutaneous metastases without accompanying visceral involvement is presented, occurring 14 months after completion of adjuvant therapy.
  • [MeSH-major] Carcinoma, Signet Ring Cell / secondary. Rectal Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 17100038.001).
  • [ISSN] 0038-4348
  • [Journal-full-title] Southern medical journal
  • [ISO-abbreviation] South. Med. J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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48. Molina Garrido MJ, Guillén Ponce C, Soto Martínez JL, Martínez Y Sevila C, Carrato Mena A: Cutaneous metastases of lung cancer. Clin Transl Oncol; 2006 May;8(5):330-3
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  • [Title] Cutaneous metastases of lung cancer.
  • It is uncommon for a cancer to be diagnosed because of skin metastases.
  • Cutaneous metastases as initial manifestation of internal neoplasias, represent only 0.8% of total cases and implies, in general, a very advanced grade of the disease and short survival.
  • When skin metastases of an unknown primary site appear, lung cancer is the first option to be discarded in case of men, and breast cancer in case of women.
  • Lung cancer spreads to the skin in 2.8-8.7% of the cases, in advanced phases of the disease, although just in 7-23.8% of the cases, cutaneous metastases appear as first manifestation of the primary tumor.
  • Sometimes, a complete examination to discover the tumor reveals no metastases elsewhere.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Female. Humans. Male. Middle Aged. Neoplasms, Unknown Primary / diagnosis. Neoplasms, Unknown Primary / pathology. Prospective Studies. Retrospective Studies

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  • [Cites] Chest. 1994 Nov;106(5):1448-50 [7956399.001]
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  • (PMID = 16760007.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 19
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49. Mollet TW, Garcia CA, Koester G: Skin metastases from lung cancer. Dermatol Online J; 2009;15(5):1
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  • [Title] Skin metastases from lung cancer.
  • Cutaneous metastases from the lung are rare but must be ruled out in patients with suspicious skin lesions and history of smoking or lung cancer.
  • All histological types of lung cancer may metastasize to the skin and clinical lesions are variable.
  • The percentage of patients with lung cancer that develop cutaneous metastases ranges from 1 to 12 percent.
  • In 20-60 percent of cases the skin lesions present before or synchronously with the diagnosis of the primary tumor.
  • Skin lesions are often described as nodular, mobile or fixed, hard or flexible, single or multiple, and painless.
  • Histologically, cutaneous metastases from the lung are frequently moderately or poorly differentiated.
  • Treatment of solitary cutaneous metastases usually includes surgery alone or combined with chemotherapy, and/or radiation.
  • If multiple cutaneous lesions or internal metastases exist, chemotherapy is the primary option.
  • Cutaneous metastases and their primaries in the lung are usually incurable and suggest an unfortunate prognosis.
  • Poor prognostic indicators include non-resectable or small-cell primary tumors, multiple cutaneous metastases, or other distant metastases.
  • [MeSH-major] Lung Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Carcinoma / chemistry. Carcinoma / diagnosis. Carcinoma / secondary. Carcinoma / therapy. Combined Modality Therapy. Female. Humans. Incidence. Keratin-20 / analysis. Keratin-7 / analysis. Male. Nuclear Proteins / analysis. Prognosis. Transcription Factors / analysis

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  • (PMID = 19624979.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Keratin-20; 0 / Keratin-7; 0 / Nuclear Proteins; 0 / Transcription Factors; 0 / thyroid nuclear factor 1
  • [Number-of-references] 50
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50. Hu SC, Chen GS, Wu CS, Chai CY, Chen WT, Lan CC: Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center. J Am Acad Dermatol; 2009 Mar;60(3):379-87
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  • [Title] Rates of cutaneous metastases from different internal malignancies: experience from a Taiwanese medical center.
  • BACKGROUND: Previous reports regarding the rates at which various internal tumors metastasize to the skin have been limited and have only included the Caucasian population.
  • Moreover, the mechanisms that predispose certain internal malignancies to metastasize to the skin have rarely been discussed in the scientific literature.
  • OBJECTIVES: We determined the frequencies with which various internal malignancies metastasize to the skin in patients from a Taiwanese medical center.
  • We also evaluated whether expressions of chemokine receptors CCR10 and CXCR4 by tumor cells correlate with cutaneous metastatic ability.
  • METHODS: Clinical records from Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, during 20 years (1986-2006) were reviewed and cases of biopsy-proven primary internal malignancies and cutaneous metastases were identified.
  • Immunohistochemical staining with antibodies to CCR10 and CXCR4 was performed on a selected number of internal malignancies with and without skin metastases.
  • RESULTS: From 12,146 patients with internal malignancies, we found 124 cases (1.02%) with cutaneous metastases.
  • The highest rates of skin metastases were found to occur from carcinoma of the breast, followed by the lung, oral mucosa, colon and rectum, stomach, and esophagus.
  • However, the rate of cutaneous metastasis from breast cancer was much lower compared with previous studies involving Caucasians.
  • In general, adenocarcinomas gave rise to cutaneous metastases at a higher frequency compared with other histologic subtypes.
  • In addition, the expressions of CCR10 and CXCR4 by tumor cells did not correlate well with the presence or absence of skin metastases.
  • CONCLUSIONS: Different internal malignancies metastasize to the skin with different frequencies, and the rates at which different malignancies metastasize to cutaneous sites differ between the Taiwanese and Caucasian populations.
  • The mechanisms responsible for the cutaneous metastatic ability of certain malignancies likely involve factors other than chemokine receptors CCR10 and CXCR4, because their expressions by tumor cells are neither necessary nor sufficient for the formation of skin metastases.
  • [MeSH-major] Adenocarcinoma / ethnology. Adenocarcinoma / secondary. Breast Neoplasms / ethnology. Breast Neoplasms / pathology. Skin Neoplasms / ethnology. Skin Neoplasms / secondary
  • [MeSH-minor] Academic Medical Centers / statistics & numerical data. Asian Continental Ancestry Group / statistics & numerical data. Carcinoma, Hepatocellular / ethnology. Carcinoma, Hepatocellular / metabolism. Carcinoma, Hepatocellular / secondary. Carcinoma, Squamous Cell / ethnology. Carcinoma, Squamous Cell / metabolism. Carcinoma, Squamous Cell / secondary. Carcinoma, Transitional Cell / ethnology. Carcinoma, Transitional Cell / metabolism. Carcinoma, Transitional Cell / secondary. Gastrointestinal Neoplasms / ethnology. Gastrointestinal Neoplasms / metabolism. Gastrointestinal Neoplasms / pathology. Humans. Immunohistochemistry. Liver Neoplasms / ethnology. Liver Neoplasms / metabolism. Liver Neoplasms / pathology. Lung Neoplasms / ethnology. Lung Neoplasms / metabolism. Lung Neoplasms / pathology. Mouth Neoplasms / ethnology. Mouth Neoplasms / metabolism. Mouth Neoplasms / pathology. Receptors, CCR10 / metabolism. Receptors, CXCR4 / metabolism. Retrospective Studies. Taiwan / epidemiology. Urinary Bladder Neoplasms / ethnology. Urinary Bladder Neoplasms / metabolism. Urinary Bladder Neoplasms / pathology

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  • (PMID = 19056145.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCR10 protein, human; 0 / CXCR4 protein, human; 0 / Receptors, CCR10; 0 / Receptors, CXCR4
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51. Kavgaci H, Yildiz B, Cobanoglu U, Fidan E, Ozdemir F, Aydin F: Laryngeal squamous cell carcinoma with knee and heel skin metastases: a case report. Acta Dermatovenerol Croat; 2010;18(1):32-4
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  • [Title] Laryngeal squamous cell carcinoma with knee and heel skin metastases: a case report.
  • Distant metastases from laryngeal carcinoma are frequently seen in the lung, bone and liver, while skin metastases are rarely observed.
  • Skin metastasis in lower extremity has only been reported in a few cases.
  • While being an indicator of poor prognosis, skin metastasis is also considered as a messenger of distant organ metastasis.
  • Survival is very short after development of skin metastasis.
  • In our case, nodular skin metastasis was found both in the superior-lateral margin of the left patella and in the right heel.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Heel. Knee. Laryngeal Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 20361886.001).
  • [ISSN] 1847-6538
  • [Journal-full-title] Acta dermatovenerologica Croatica : ADC
  • [ISO-abbreviation] Acta Dermatovenerol Croat
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Croatia
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52. Weinreb I, Cunningham KS, Perez-Ordoñez B, Hwang DM: CD10 is expressed in most epithelioid hemangioendotheliomas: a potential diagnostic pitfall. Arch Pathol Lab Med; 2009 Dec;133(12):1965-8

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • CONTEXT: -Epithelioid hemangioendothelioma (EHE) is a vascular neoplasm that occasionally is difficult to distinguish from primary/metastatic carcinomas, particularly when EHEs express keratins.
  • Tumors were located in liver (3), skin (2), lung/pleura (2), and sternomastoid and mediastinum (1 each).
  • Two had skin metastases.
  • The 2 skin metastases were positive, whereas 2 primary skin EHEs were negative.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Hemangioendothelioma, Epithelioid / metabolism. Neprilysin / biosynthesis
  • [MeSH-minor] Adult. Aged. Antigens, CD34 / analysis. Biomarkers, Tumor / analysis. Carcinoma, Renal Cell / diagnosis. Carcinoma, Renal Cell / metabolism. Diagnosis, Differential. Epithelioid Cells / chemistry. Epithelioid Cells / pathology. Female. Hemangiosarcoma / diagnosis. Hemangiosarcoma / metabolism. Humans. Immunohistochemistry. Kidney Neoplasms / diagnosis. Kidney Neoplasms / metabolism. Male. Middle Aged. Sensitivity and Specificity. Young Adult

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  • (PMID = 19961253.001).
  • [ISSN] 1543-2165
  • [Journal-full-title] Archives of pathology & laboratory medicine
  • [ISO-abbreviation] Arch. Pathol. Lab. Med.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Biomarkers, Tumor; EC 3.4.24.11 / Neprilysin
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53. Arcara C, Fulfaro F, Badalamenti G, Gebbia N, Arcara M: A case of squamocellular uterine cervix carcinoma metastatic to the skin with enterocutaneous fistula. Tumori; 2006 May-Jun;92(3):264-6
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  • [Title] A case of squamocellular uterine cervix carcinoma metastatic to the skin with enterocutaneous fistula.
  • Metastases to the skin complicated by enterocutaneous fistula are a rare event in gynecological malignancies.
  • We present the case of a 70-year-old woman with uterine cervix carcinoma metastatic to the skin and treated with surgery and radiotherapy.
  • The last relapse to the skin was complicated by the formation of an enterocutaneous fistula.
  • The treatment of enterocutaneous fistulas may be either invasive (surgical resection, surgical repair with corrective procedures or with myocutaneous flaps, colonic and/or urinary diversion, endoscopic treatments with metallic stents) or conservative (skin care and local disinfection, pouching of secretions, control of nutrition and electrolytes, TPN, antisecretory treatment with scopolamine or octreotide, and control of psychological conditions).
  • Enterocutaneous fistulas associated with skin metastases are not commonly reported in the literature and may be successfully treated with surgery and supportive care in patients with good performance status and no evidence of further metastatic disease.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Ileal Diseases / etiology. Intestinal Fistula / etiology. Skin Neoplasms / complications. Skin Neoplasms / secondary. Uterine Cervical Neoplasms / pathology


54. Fujimura T, Okuyama R, Ohtani T, Ito Y, Haga T, Hashimoto A, Aiba S: Perilesional treatment of metastatic melanoma with interferon-beta. Clin Exp Dermatol; 2009 Oct;34(7):793-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Perilesional treatment of metastatic melanoma with interferon-beta.
  • Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM).
  • We report three patients who were treated with peritumoral injection of interferon (IFN)-beta for multiple skin metastases of MM.
  • The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen-DR+ cells increased after IFN-beta injection.
  • These results suggest that the peritumoral administration of IFN-beta enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Interferon-beta / therapeutic use. Melanoma / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. CD4 Lymphocyte Count. Cells, Cultured. Dendritic Cells / drug effects. Drug Evaluation / methods. Female. HLA-DR Antigens / metabolism. Humans. Injections, Intralesional. Lymphocytes, Tumor-Infiltrating / drug effects. Male. Middle Aged. T-Lymphocytes, Cytotoxic / immunology

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  • (PMID = 19438554.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / HLA-DR Antigens; 77238-31-4 / Interferon-beta
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55. Blumer SL, Scalcione LR, Ring BN, Johnson R, Motroni B, Katz DS, Yung EY: Cutaneous and subcutaneous imaging on FDG-PET: benign and malignant findings. Clin Nucl Med; 2009 Oct;34(10):675-83

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous and subcutaneous imaging on FDG-PET: benign and malignant findings.
  • However, false-positive interpretations may occur from benign subcutaneous and cutaneous etiologies.
  • At our institution we have encountered FDG-PET scans which demonstrated a variety of cutaneous and subcutaneous lesions including stomas, hernias, rhinophyma, dose infiltrations, physiologic muscle uptake, and tophaceous gout.
  • Additionally, malignant cutaneous and subcutaneous malignant lesions may also demonstrate substantial F-18 FDG uptake on PET scans, including lymphoma, skin metastases, and melanoma.
  • The purpose of this atlas article is to demonstrate and review key features of various cutaneous and subcutaneous lesions, both benign and malignant, which can result in hypermetabolism on FDG-PET or PET-CT scans.
  • [MeSH-major] Fluorodeoxyglucose F18. Neoplasms / radiography. Neoplasms / radionuclide imaging. Positron-Emission Tomography. Skin / radiography. Skin / radionuclide imaging

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  • (PMID = 19893399.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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56. Sakurai K, Enomoto K, Kitajima A, Tani M, Amano S: [A case of advanced breast cancer successfully treated with multi-disciplinary therapy and S-1 administration]. Gan To Kagaku Ryoho; 2007 Nov;34(12):2065-7
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  • [Title] [A case of advanced breast cancer successfully treated with multi-disciplinary therapy and S-1 administration].
  • We report a case of advanced breast cancer (T4b, N3c, M1) achieving a significant improvement on QOL by multi-disciplinary therapy and S-1 administration.
  • A core needle biopsy for breast tumor led to a diagnosis of an invasive ductal carcinoma negative for estrogen receptor, progesterone receptor, and HER2/neu protein expression.
  • The aspiration biopsy cytology was performed from skin lesion, the diagnosis was class V.
  • The effect of the breast tumor was partial response, and the bleeding from the breast lump was improved.
  • But the response from metastatic skin tumor was less satisfactory.
  • We performed a radiation therapy (20 Gy) to metastatic skin tumor, and the lesion disappeared after the radiation therapy.
  • Multi-disciplinary therapy can improve a patient QOL and the clinical outcomes in Stage IV advanced breast cancer.
  • [MeSH-minor] Biopsy, Needle. Drug Combinations. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Tomography, X-Ray Computed

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  • (PMID = 18219900.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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57. Block CA, Dahmoush L, Konety BR: Cutaneous metastases from transitional cell carcinoma of the bladder. Urology; 2006 Apr;67(4):846.e15-7
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  • [Title] Cutaneous metastases from transitional cell carcinoma of the bladder.
  • Cutaneous metastases from primary genitourinary malignancies are rare and usually represent a poor prognostic sign.
  • Very few cases of skin metastases from urothelial carcinoma have been reported in the past, and most of them were treated with chemotherapy.
  • We report a patient with transitional cell carcinoma of the bladder who developed skin metastases after cystectomy.
  • [MeSH-major] Carcinoma, Transitional Cell / secondary. Skin Neoplasms / secondary. Urinary Bladder Neoplasms / pathology


58. Otsu U, Fukui N, Iki M, Moriwaki S, Kiyokane K: Case of cutaneous malignant melanoma surviving 16 years with late recurrence. J Dermatol; 2009 Nov;36(11):598-603
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  • [Title] Case of cutaneous malignant melanoma surviving 16 years with late recurrence.
  • Late recurrence, defined as that occurring 10 or more years after diagnosis, is an unusual event in cutaneous malignant melanoma (MM).
  • She was diagnosed with MM and the tumor was totally excised with 5 cm of the normal surrounding skin.
  • Eleven years after the operation, five in-transit metastases were found in her right limb.
  • They were all excised and beta-interferon (IFN-beta) was injected into the skin around the postoperative scars.
  • However, numerous new in-transit skin metastases have been emerging every year in her right limb.
  • Fifty-four in-transit skin metastases have so far been found.
  • Recently, there have been few in-transit metastases.
  • All in-transit metastatic lesions were excised and local IFN-beta injections were conducted continuously.
  • There is no evidence of metastases to the internal organs or lymph nodes.
  • [MeSH-major] Foot / pathology. Interferons / administration & dosage. Melanoma / pathology. Neoplasm Invasiveness / pathology. Neoplasm Recurrence, Local / pathology. Skin Neoplasms / pathology

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  • (PMID = 19878393.001).
  • [ISSN] 1346-8138
  • [Journal-full-title] The Journal of dermatology
  • [ISO-abbreviation] J. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 9008-11-1 / Interferons
  • [Number-of-references] 14
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59. Stryker JE, Solky BA, Emmons KM: A content analysis of news coverage of skin cancer prevention and detection, 1979 to 2003. Arch Dermatol; 2005 Apr;141(4):491-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A content analysis of news coverage of skin cancer prevention and detection, 1979 to 2003.
  • OBJECTIVE: To analyze newspaper coverage between 1979 and 2003 to understand how print coverage may affect primary and secondary skin cancer prevention in the US population.
  • DESIGN: Content analysis of 921 skin cancer articles released by the Associated Press during the study period.
  • MAIN OUTCOME MEASURES: Amount of attention given to primary and secondary prevention practices and to risk communication.
  • RESULTS: Media attention to skin cancer has not increased since 1986.
  • Dermatologic detection (6.6%) or self-detection (5.5%) of skin cancer was rarely discussed.
  • Risk communication about skin cancer was suboptimal: articles rarely presented absolute and relative risk.
  • CONCLUSIONS: The media pay little attention to skin cancer, and, in general, stories do not contain important educational information.
  • [MeSH-major] Health Education / organization & administration. Health Education / standards. Mass Media. Primary Prevention / methods. Skin Neoplasms / prevention & control

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  • [CommentIn] Arch Dermatol. 2005 Apr;141(4):499-501 [15837869.001]
  • (PMID = 15837868.001).
  • [ISSN] 0003-987X
  • [Journal-full-title] Archives of dermatology
  • [ISO-abbreviation] Arch Dermatol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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60. Patel T, Bansal R, Trivedi P, Modi L, Shah MJ: Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report. Indian J Pathol Microbiol; 2005 Oct;48(4):482-4
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  • [Title] Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration--a case report.
  • Metastasis of mesothelioma of the pleura, to the skin and subcutis is an extremely rare occurrence.
  • A 25 year old woman, who had undergone chemotherapy, partial excision of tumor followed by radiotherapy of sarcomatoid mesothelioma of the pleura, presented three months later with painless widespread subcutaneous nodules.
  • FNAC of these nodules reveled pleomorphic malignant spindle shaped cell with epithelioid morphology.
  • The subcutis is a particularly rare site of metastatic sarcomatoid mesothelioma.
  • It is essential to differentiate neoplasm metastatic to the skin and subcutis from primary and benign lesions of the same region.
  • FNAC is accurate and efficient, in conjugation with clinical history, and it also prevents surgical biopsy in the diagnosis of metastatic subcutaneous lesion.
  • [MeSH-major] Mesothelioma / diagnosis. Soft Tissue Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy, Fine-Needle. Diagnosis, Differential. Female. Humans. Pleural Neoplasms. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary. Subcutaneous Tissue

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  • (PMID = 16366102.001).
  • [ISSN] 0377-4929
  • [Journal-full-title] Indian journal of pathology & microbiology
  • [ISO-abbreviation] Indian J Pathol Microbiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] India
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61. Elawar A, Dandurand M, Jumez N, Delfour C, Branchereau P, Stoebner P, Meunier L: [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta]. Ann Dermatol Venereol; 2010 Feb;137(2):111-6
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  • [Title] [Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta].
  • [Transliterated title] Métastases cutanées révélatrices d'un angiosarcome épithélioïde de l'aorte abdominale.
  • We report a case revealed by skin metastasis.
  • CASE REPORT: An 85-year-old man presented skin tumours associated with deterioration of his general condition and intense pain of the right lower limb.
  • Histological examination of a nodule showed proliferation of malignant cells with expression of vimentin, CD 31, cytokeratins AE1/AE3 and cytokeratin 7.
  • Moreover, skin and osseous F-FDG uptake was seen.
  • These findings suggested a diagnosis of EAS of the aorta with skin and osseous metastasis and vascular emboli.
  • These tumours typically arise in the abdominal aorta in association with metastasis in more than 80% of cases.
  • Skin metastasis causes papular eruption, nodules and peripheral vascular disease.
  • Our case report emphasizes four key points: the diagnostic value of an association of localized malignant skin tumours, extensive livedo, ipsilateral distal ischaemia, deterioration of the general condition and intense pain; the diagnostic value of endothelial markers, especially CD31, and potentially misleading co-expression of cytokeratin markers; in selected cases, additional imaging, such as PET scans, performed in our case for the first time prior to surgery of the aorta, may be helpful for the diagnosis of such neoplastic lesions of the aortic wall.
  • [MeSH-major] Aorta, Abdominal / pathology. Hemangiosarcoma / pathology. Hemangiosarcoma / secondary. Skin Neoplasms / secondary. Vascular Neoplasms / pathology

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  • [Copyright] Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.
  • (PMID = 20171432.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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62. Coman I, Crişan N, Petrut B, Bungărdean C, Cristea T, Crişan D: Hepatic and skin metastases after laparoscopic radical prostatectomy for prostate cancer. J Gastrointestin Liver Dis; 2007 Sep;16(3):333-5
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  • [Title] Hepatic and skin metastases after laparoscopic radical prostatectomy for prostate cancer.
  • Between 2004 and 2006, 50 radical prostatectomies were performed in our department, 46 of them through a laparoscopic approach addressed to early stage cancer (T1a,b,c and T2a,b,c N0 M0).
  • We present the case of a 63 year old patient, who was initially diagnosed with prostate cancer in T1bN0M0 stage, Gleason score 8 and later presented atypical hepatic and trocar site metastases.
  • The rarity of this atypical metastases and its association, the diagnostic and therapy problems are the reasons for the detailed presentation of this case.
  • [MeSH-major] Adenocarcinoma. Carcinoma in Situ. Liver Neoplasms / secondary. Prostatic Neoplasms. Skin Neoplasms / secondary
  • [MeSH-minor] Follow-Up Studies. Humans. Laparoscopy. Liver / pathology. Male. Middle Aged. Neoplasm Staging. Prostate / pathology. Surgical Instruments. Time Factors. Transurethral Resection of Prostate

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  • (PMID = 17925932.001).
  • [ISSN] 1841-8724
  • [Journal-full-title] Journal of gastrointestinal and liver diseases : JGLD
  • [ISO-abbreviation] J Gastrointestin Liver Dis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Romania
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63. Yoneyama K, Hata K, Kanamoto A, Tsurita G, Ito A, Shinozaki M, Tahara H: [Weekly injection of paclitaxel plus weekly oral administration of cyclophosphamide were very effective for a case of advanced accessory breast cancer]. Gan To Kagaku Ryoho; 2010 Aug;37(8):1561-3
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  • [Title] [Weekly injection of paclitaxel plus weekly oral administration of cyclophosphamide were very effective for a case of advanced accessory breast cancer].
  • Reported is a case of advanced accessory breast cancer to which weekly injection of paclitaxel plus weekly oral administration of cyclophosphamide proved very effective.
  • The patient was a 49-year-old woman who noticed a tumor in the right axilla around October 2007 but then left it alone.
  • In October 2008, the patient visited a nearby physician who made a diagnosis of locally advanced accessory breast cancer.
  • Because the tumor enlarged despite endocrinotherapy, the patient was referred to our hospital in July 2009.
  • CT scan showed a tumor with a size of infant's head, multiple lymph node metastases and metastases to the skin, liver and bones.
  • Following weekly injection of paclitaxel plus weekly oral administration of cyclophosphamide for 4 months, the tumor in the right axilla and metastases to the lymph nodes, skin and liver disappeared.
  • [MeSH-minor] Administration, Oral. Biomarkers, Tumor / blood. Biopsy, Needle. Female. Humans. Infusions, Intravenous. Middle Aged. Tomography, X-Ray Computed

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  • (PMID = 20716887.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 8N3DW7272P / Cyclophosphamide; P88XT4IS4D / Paclitaxel
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64. Chan AL, Juarez M, Allen R, Volz W, Albertson T: Pharmacokinetics and clinical effects of mono-L-aspartyl chlorin e6 (NPe6) photodynamic therapy in adult patients with primary or secondary cancer of the skin and mucosal surfaces. Photodermatol Photoimmunol Photomed; 2005 Apr;21(2):72-8
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  • [Title] Pharmacokinetics and clinical effects of mono-L-aspartyl chlorin e6 (NPe6) photodynamic therapy in adult patients with primary or secondary cancer of the skin and mucosal surfaces.
  • A single intravenous dose of Npe6 was administered to 14 cancer patients with superficial malignancies (basal cell carcinoma = 22 lesions, squamous cell cancer = 13 lesions, papillary carcinoma = 14 lesions).
  • The total light dose (range 25-200 J/cm2) depended on the tumor shape and size.
  • The toxicity and cutaneous clinical efficacy of NPe6 were observed.
  • Eighteen of 27 other malignant cutaneous tumors showed a complete (n = 15/27, 56%) or partial (n = 3/27, 11%) response.
  • CONCLUSION: The photosensitizer, NPe6, was well tolerated with minimal phototoxic side effects, and demonstrated preliminary efficacy against cutaneous malignancies.
  • [MeSH-major] Photochemotherapy. Photosensitizing Agents / administration & dosage. Porphyrins / administration & dosage. Skin Neoplasms / drug therapy

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  • (PMID = 15752124.001).
  • [ISSN] 0905-4383
  • [Journal-full-title] Photodermatology, photoimmunology & photomedicine
  • [ISO-abbreviation] Photodermatol Photoimmunol Photomed
  • [Language] eng
  • [Publication-type] Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Photosensitizing Agents; 0 / Porphyrins; P4ROX5ELT2 / Talaporfin
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65. Lazaro M, Allende I, Ratón JA, Acebo E, Diaz-Perez JL: Cutaneous metastases of hepatocellular carcinoma. Clin Exp Dermatol; 2009 Dec;34(8):e567-9
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  • [Title] Cutaneous metastases of hepatocellular carcinoma.
  • Cutaneous metastases are an unusual finding that may present as the first sign of an internal neoplasia.
  • A case of cutaneous metastases of hepatocellular carcinoma, which may often involve other organs but very rarely metastases to the skin, is reported.
  • [MeSH-major] Carcinoma, Hepatocellular / secondary. Liver Neoplasms / pathology. Nose Neoplasms / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor. Diagnosis, Differential. Humans. Male. Middle Aged

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  • [ErratumIn] Clin Exp Dermatol. 2010 Jan;35(1):110. Serrano, M L [corrected to Lazaro, M]; Allende, I [added]; Ratón, J A [added]; Acebo, E [added]; Diaz-Perez, J L [added]
  • (PMID = 19489869.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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66. Matsumoto K, Kubo H, Murata H, Uhara H, Takata M, Shibata S, Yasue S, Sakakibara A, Tomita Y, Kageshita T, Kawakami Y, Mizuno M, Yoshida J, Saida T: A pilot study of human interferon beta gene therapy for patients with advanced melanoma by in vivo transduction using cationic liposomes. Jpn J Clin Oncol; 2008 Dec;38(12):849-56
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  • HuIFNbeta gene therapy showed much higher anti-tumor activity compared with the administration of HuIFNbeta protein for melanoma.
  • METHODS: Stage IV or III melanoma patients with cutaneous or subcutaneous metastatic lesions were enrolled in this pilot study.
  • IAB-1 was dissolved by sterile PBS at a concentration of 30 microg DNA/ml and was injected into cutaneous or subcutaneous metastatic nodules three times a week for 2 weeks and the effect on the injected and non-injected metastatic lesions was evaluated.
  • In the MR patient, the IAB-1 injected lesion disappeared clinically and histopathologically and one-half of IAB-1 non-injected skin metastases were transiently inflamed and mostly regressed.
  • In the responded non-injected lesions of this patient, histopathologically, infiltration of CD4 positive T cells was observed around the melanoma cells in the dermis, which expressed the HLA-Class II antigen.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Genetic Therapy / methods. Interferon-beta / administration & dosage. Interferon-beta / genetics. Melanoma / therapy. Skin Neoplasms / therapy. Transduction, Genetic

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  • (PMID = 18945721.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Cations; 0 / Liposomes; 77238-31-4 / Interferon-beta
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67. Santarpia L, El-Naggar AK, Sherman SI, Hymes SR, Gagel RF, Shaw S, Sarlis NJ: Four patients with cutaneous metastases from medullary thyroid cancer. Thyroid; 2008 Aug;18(8):901-5
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  • [Title] Four patients with cutaneous metastases from medullary thyroid cancer.
  • Cutaneous metastasis from thyroid cancer, especially medullary thyroid cancer (MTC) is rare.
  • We report four patients with cutaneous metastases from sporadic MTC, three women and one man, aged 50 to 69 years.
  • They presented different cutaneous lesions phenotypes.
  • The first patient had a remote history of MTC and initial presentation of the recurrence was a rapidly progressing cutaneous lesion; on subsequent disease staging, widely metastatic disease was discovered.
  • The other three patients developed cutaneous metastases in the presence of known distant metastases, indicating systemic spread of thyroid cancer.
  • Definitive diagnosis of cutaneous metastases of MTC was made on biopsy of the lesions with cells that stained positive for neuroendocrine markers.
  • Accurate diagnosis of cutaneous metastasis from MTC is important because it is a negative prognostic factor indicative of multisystemic disease.
  • Thus, MTC metastases should be included in the differential diagnosis of erythematous maculopapular eruptions and nodular lesions of the skin, especially when these metastases occur in the upper part of the body and if the patient has a history of MTC.
  • The appearing of cutaneous metastasis is a negative prognostic factor since all the patients here described died within one year from the diagnosis of cutaneous metastases.
  • [MeSH-major] Carcinoma, Medullary / pathology. Skin Neoplasms / secondary. Thyroid Neoplasms / pathology


68. Barratt G, Saint-Pierre-Chazalet M, Loiseau PM: Cellular transport and lipid interactions of miltefosine. Curr Drug Metab; 2009 Mar;10(3):247-55
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  • Miltefosine (hexadecylphosphocholine, HePC) is an alkyl phospholipid which was first developed as an anticancer agent for local treatment of skin metastases.
  • The uptake of HePC by cancer cells begins by insertion into the plasma membrane which may be followed by internalization.

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  • (PMID = 19442087.001).
  • [ISSN] 1389-2002
  • [Journal-full-title] Current drug metabolism
  • [ISO-abbreviation] Curr. Drug Metab.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Liposomes; 0 / Membrane Lipids; 107-73-3 / Phosphorylcholine; 53EY29W7EC / miltefosine
  • [Number-of-references] 105
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69. Notohamiprodjo M, Segerer S, Huss R, Hildebrandt B, Soler D, Djafarzadeh R, Buck W, Nelson PJ, von Luettichau I: CCR10 is expressed in cutaneous T-cell lymphoma. Int J Cancer; 2005 Jul 1;115(4):641-7
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  • [Title] CCR10 is expressed in cutaneous T-cell lymphoma.
  • Cutaneous T-cell lymphoma (CTCL) is characterized by recruitment of malignant T-cell clones into the skin.
  • The mechanisms involved in tumor homing are still not fully elucidated, though chemokines and chemokine receptors have been suggested to play a role in the pathogenesis.
  • Here, we demonstrate extensive expression of CCR10 in skin biopsies of patients with Sezary syndrome (SS, n = 3), mycosis fungoides (MF, n = 2) and unspecified CTCL (n = 3).
  • Expression of CCR5 was detected in 2 of the examined skin biopsies.
  • Our data support a potential role of CXCR3 in CTCL and strongly suggest that CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in this group of lymphoproliferative disorders.
  • [MeSH-major] Lymphoma, T-Cell, Cutaneous / genetics. Receptors, Chemokine / genetics. Skin Neoplasms / genetics
  • [MeSH-minor] Aged. Aged, 80 and over. Cell Line, Tumor. Cell Movement. DNA Primers. Female. Humans. Immunohistochemistry. Jurkat Cells. Male. Middle Aged. RNA, Messenger / genetics. Receptors, CCR10. Reverse Transcriptase Polymerase Chain Reaction

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  • [Copyright] Copyright 2005 Wiley-Liss, Inc.
  • (PMID = 15700309.001).
  • [ISSN] 0020-7136
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCR10 protein, human; 0 / DNA Primers; 0 / RNA, Messenger; 0 / Receptors, CCR10; 0 / Receptors, Chemokine
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70. van Ruth S, van Dorst EB, Canninga-van Dijk MR, de Bruin-Weller MS: A leg ulcer as manifestation of metastatic squamous cell vaginal carcinoma. J Eur Acad Dermatol Venereol; 2007 May;21(5):678-80
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  • [Title] A leg ulcer as manifestation of metastatic squamous cell vaginal carcinoma.
  • Cutaneous metastasis of vaginal carcinoma is extremely rare.
  • So far, the total number of reported skin metastasis of vaginal carcinoma is only one.
  • We present another case with an unusual manifestation of vagina carcinoma metastasis: skin metastasis presenting as a leg ulcer on the lower leg.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Leg Ulcer / pathology. Skin Neoplasms / secondary. Vaginal Neoplasms / pathology


71. Nggada HA, Ajayi NA: Cutaneous metastasis from hepatocellular carcinoma: a rare presentation and review of the literature. Afr J Med Med Sci; 2006 Jun;35(2):181-2
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  • [Title] Cutaneous metastasis from hepatocellular carcinoma: a rare presentation and review of the literature.
  • A 53-year-old male Nigerian with a rare cutaneous metastasis and a late manifestation of hepatocellular carcinoma is presented.
  • The skin nodules were umbilicated, painless. firm and spread on the chest, abdomen and back.
  • Fine needle aspiration cytology of the liver revealed hepatocellular carcinoma and the skin nodule, metastatic carcinoma of hepatic origin.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 17209317.001).
  • [ISSN] 0309-3913
  • [Journal-full-title] African journal of medicine and medical sciences
  • [ISO-abbreviation] Afr J Med Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Nigeria
  • [Number-of-references] 10
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72. Bray AP, Wong NA, Narayan S: Cutaneous metastasis from gastric glomus tumour. Clin Exp Dermatol; 2009 Dec;34(8):e719-21
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  • [Title] Cutaneous metastasis from gastric glomus tumour.
  • Owing to diagnostic difficulties with the scalp tumour, a comparison was made with the previous gastric neoplasm.
  • Both had features consistent with glomus tumour, which suggested a revised diagnosis of primary malignant gastric glomus tumour with subsequent cutaneous metastasis to the scalp some years later.
  • This case highlights the features of glomus tumours and is a reminder that although rare, glomus tumours can be malignant and have the potential to metastasize.
  • To our knowledge, this is the only reported case of a primary gastric glomus tumour with secondary metastasis to the skin.
  • [MeSH-major] Glomus Tumor / secondary. Head and Neck Neoplasms / secondary. Scalp / pathology. Skin Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 19758389.001).
  • [ISSN] 1365-2230
  • [Journal-full-title] Clinical and experimental dermatology
  • [ISO-abbreviation] Clin. Exp. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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73. van Luijk IF, Coens C, van der Burg ME, Kobierska A, Namer M, Lhomme C, Zola P, Zanetta G, Vermorken JB, Gynecological Cancer Group of the European Organization for Research and Treatment of Cancer: Phase II study of bleomycin, vindesine, mitomycin C and cisplatin (BEMP) in recurrent or disseminated squamous cell carcinoma of the uterine cervix. Ann Oncol; 2007 Feb;18(2):275-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • OBJECTIVE: We carried out a phase II trial with BEMP [bleomycin, vindesine (Eldisine(R)), mitomycin C and cisplatin] in patients with recurrent and/or metastatic squamous cell carcinoma of the uterine cervix with the specific aim to assess whether BEMP was of particular interest when certain disease sites were involved.
  • PATIENTS AND METHODS: Eligible patients received four cycles of E 3 mg/m(2), day 1 + 8; P 50 mg/m(2), day 1; B 15 mg/day (continuous infusion), day 2-4 and M 8 mg/m(2), day 5 (on alternate cycles), every 3 weeks during an induction phase.
  • MEP consisted of E 3 mg/m(2), day 1 + 8, M 6 mg/m(2) (on alternate cycles) and P 50 mg/m(2), both on day 1.
  • Most responsive disease sites were lung, lymph nodes and skin metastases (>60% response, CR rate >25%).
  • Survival was significantly better in patients with only distant metastases: 12.9 months versus 8.6 months in those with other disease sites involved (P = 0.002).
  • In a multivariate analysis, patients with a good performance status yielded a better prognosis (P = 0.0017), as did the patients with only metastatic disease compared with those who had pelvic disease also or solely (P = 0.045).
  • CONCLUSIONS: Patients with a good performance status and only distant metastases seem optimal candidates to receive the BEMP regimen.


74. Barabás J, Suba Z, Szabó G, Ujpál M: [Malignant melanoma metastasis in the oral cavity]. Fogorv Sz; 2006 Aug;99(4):149-52
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  • [Title] [Malignant melanoma metastasis in the oral cavity].
  • Malignant melanoma occurs only rarely as a primary tumour in the oral cavity, with an incidence of 1-2 percent.
  • Mucosal malignant melanomas are much more aggressive than those situated in the skin.
  • In two-thirds of the cases the route of formation of the metastases is lymphogenic, and haematogenic in the remainder.
  • The typical sites of the distant metastases are the skin, the lungs, the brain, the liver, and the bones.
  • Metastatic malignant melanoma in the oral cavity, a rarity in the literature, is associated with a very poor prognosis.
  • This paper reports on two cases in which an isolated distant metastasis developed in the oral cavity.
  • [MeSH-major] Melanoma. Mouth Neoplasms. Skin Neoplasms
  • [MeSH-minor] Adult. Female. Gingival Neoplasms / diagnosis. Gingival Neoplasms / secondary. Gingival Neoplasms / surgery. Humans. Male. Mandibular Neoplasms / diagnosis. Mandibular Neoplasms / secondary. Mandibular Neoplasms / surgery. Middle Aged. Prognosis

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  • (PMID = 17016922.001).
  • [ISSN] 0015-5314
  • [Journal-full-title] Fogorvosi szemle
  • [ISO-abbreviation] Fogorv Sz
  • [Language] hun
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Hungary
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75. L P, L LR, N E, B KS: Malignant melanoma - cutaneous metastases. Indian J Dermatol; 2008;53(4):212-4
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  • [Title] Malignant melanoma - cutaneous metastases.
  • Melanoma composed of melanocytes may arise in the skin or other tissues harboring melanocytes, such muco-cutaneous junctions, mucosa including the conjunctiva, iris, choroids and substantia nigra.1 Metastases to the skin and subcutaneous tissues from a malignant melanoma are less common.
  • A case of multiple painless nodules on the body that revealed metastatic deposits of melanoma on histopathological examination is being reported.

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  • [Cites] Cancer. 1964 Oct;17:1323-39 [14236766.001]
  • (PMID = 19882041.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2763751
  • [Keywords] NOTNLM ; Cutaneous metastases / maignant / melanoma
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76. Mukhia R, Shrestha S, Malla K, Sharma VK: Cutaneous metastases from carcinoma of gall bladder. JNMA J Nepal Med Assoc; 2009 Oct-Dec;48(176):318-20
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  • [Title] Cutaneous metastases from carcinoma of gall bladder.
  • Cutaneous metastases from internal carcinoma are relatively rare.
  • Metastasis to extremities is still rarer.
  • We report a case of cutaneous metastasis from carcinoma of gall bladder in a 40-year female presenting as a mass in the left lower thigh.
  • The skin overlying the swelling was eroded with ulcer formation showing sloping edge and slough in the floor.
  • Fine needle aspiration cytology and excisional biopsy revealed a metastatic adenocarcinoma.
  • Cutaneous metastases have been regarded as a bad prognostic indicator.
  • [MeSH-major] Carcinoma / secondary. Gallbladder Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 21105558.001).
  • [ISSN] 0028-2715
  • [Journal-full-title] JNMA; journal of the Nepal Medical Association
  • [ISO-abbreviation] JNMA J Nepal Med Assoc
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nepal
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77. Shekhel T, Glick RM, Cranmer LD: In-transit metastasis from melanoma presenting as lymphangiectasis: a case report. Cutis; 2009 Sep;84(3):151-8
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  • [Title] In-transit metastasis from melanoma presenting as lymphangiectasis: a case report.
  • Malignant melanoma as a cause of inflammatory metastasis to the skin is a rare phenomenon referred to as in-transit metastasis (ITM).
  • [MeSH-major] Lymphangiectasis / diagnosis. Melanoma / diagnosis. Skin Neoplasms / diagnosis
  • [MeSH-minor] Adult. Biopsy / methods. Humans. Inflammation / etiology. Inflammation / pathology. Leg / pathology. Male. Neoplasm Metastasis

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  • (PMID = 19842575.001).
  • [ISSN] 0011-4162
  • [Journal-full-title] Cutis
  • [ISO-abbreviation] Cutis
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Kimura T, Kiyota H, Nakata D, Masaki T, Kusaka M, Egawa S: A novel androgen-dependent prostate cancer xenograft model derived from skin metastasis of a Japanese patient. Prostate; 2009 Nov 1;69(15):1660-7
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  • [Title] A novel androgen-dependent prostate cancer xenograft model derived from skin metastasis of a Japanese patient.
  • BACKGROUND: The incidence of, and mortality from, prostate cancer (PCa) has increased in Asian countries over the past decades, partly due to a change in dietary habits.
  • PCa xenograft models established from Asian patients would be useful for understanding the basis of PCa in Asian populations; we therefore established and characterized a novel PCa xenograft model, JDCaP, from a metastatic skin lesion of a Japanese hormone-refractory prostate cancer (HRPC) patient.
  • METHODS: Skin metastatic tissue derived from poorly differentiated prostatic adenocarcinoma in a 61-year-old Japanese male was transplanted to nude mice and JDCaP was established by serial passage.
  • Only testosterone administration maintained tumor proliferation after orchiectomy.
  • Administration of leuprorelin acetate, bicalutamide, and flutamide inhibited tumor growth.
  • [MeSH-major] Adenocarcinoma / secondary. Neoplasms, Hormone-Dependent / pathology. Prostatic Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Animals. Antigens, Neoplasm / metabolism. Antineoplastic Agents, Hormonal / pharmacology. Asian Continental Ancestry Group. Diethylstilbestrol / pharmacology. Humans. Leuprolide / pharmacology. Male. Mice. Mice, Inbred BALB C. Mice, Nude. Middle Aged. Neoplasm Transplantation. Receptors, Androgen / metabolism. Specific Pathogen-Free Organisms. Transplantation, Heterologous


79. Küsters-Vandevelde HV, Keunen JE, Wesseling P, Verdijk MA, Ligtenberg MJ, Blokx WA: Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis. Virchows Arch; 2008 Mar;452(3):331-6
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  • [Title] Occurrence of ocular melanoma thirteen years after skin melanoma: two separate primaries or metastatic disease? A case solved with NRAS and CDKN2A (INK4A-ARF) mutational analysis.
  • The differential diagnosis between primary uveal melanoma and cutaneous melanoma metastasis in the eye may be difficult, both clinically and histologically.
  • The patient had a history of a superficial spreading cutaneous melanoma of the left shoulder.
  • Nine years later, she developed a lymph node metastasis in the left axilla, and 13 years later she presented with an atypical, pigmented tumor in the uvea.
  • We performed molecular analysis on the skin melanoma, the lymph node metastasis and the uveal melanoma.
  • We detected an NRAS codon 61 mutation (c.182A>G, p.Gln61Arg) in all three tumor specimens.
  • We detected a CDKN2A mutation ((p16) c.238C>T, p.Arg80X, (p14) c.404C>T, p.Pro135Leu)) in the tumor samples, but not in the normal control tissue of the patient.
  • We concluded that the uveal melanoma is a metastasis from the cutaneous melanoma removed 13 years before.
  • [MeSH-major] Melanoma / secondary. Skin Neoplasms / pathology. Uveal Neoplasms / secondary
  • [MeSH-minor] Base Sequence. Cyclin-Dependent Kinase Inhibitor p16 / genetics. DNA Mutational Analysis. Diagnosis, Differential. Female. Humans. Middle Aged. Mutation. Proto-Oncogene Proteins B-raf / genetics. Time Factors. ras Proteins / genetics

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  • [Cites] Optom Vis Sci. 2003 May;80(5):344-55 [12771660.001]
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  • (PMID = 18205010.001).
  • [ISSN] 0945-6317
  • [Journal-full-title] Virchows Archiv : an international journal of pathology
  • [ISO-abbreviation] Virchows Arch.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Cyclin-Dependent Kinase Inhibitor p16; EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf; EC 3.6.5.2 / ras Proteins
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80. Kypson AP, Anderson CA, Lochmuller CM, Dizon K, Rodriguez E: Squamous cell carcinoma of the pericardium found during coronary bypass surgery of possible cutaneous origin. Ann Thorac Surg; 2007 Nov;84(5):1735-6
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  • [Title] Squamous cell carcinoma of the pericardium found during coronary bypass surgery of possible cutaneous origin.
  • Metastatic neoplasms of the pericardium are more common than primary tumors.
  • Isolated metastasis of cutaneous squamous cell carcinoma to the pericardium has not been described.
  • We report a case of squamous cell carcinoma of the pericardium diagnosed after coronary bypass surgery without any primary tumor.
  • The only significant history is the removal of multiple "skin cancers" in the past.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Heart Neoplasms / pathology. Pericardium / pathology. Skin Neoplasms / pathology

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  • (PMID = 17954098.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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81. Hyer SL, McAleese J, Harmer CL: Neuroendocrine carcinoma arising in soft tissue: three case reports and literature review. World J Surg Oncol; 2007;5:77

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Metastasis to the skin occurs infrequently but primary soft tissue NET is excessively rare.
  • In the third case, a cutaneous nodule proved to be a NET and at surgery, lymph node disease was present.

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  • (PMID = 17620120.001).
  • [ISSN] 1477-7819
  • [Journal-full-title] World journal of surgical oncology
  • [ISO-abbreviation] World J Surg Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1971059
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82. Erickson LA, Jin L, Nakamura N, Bridges AG, Markovic SN, Lloyd RV: Clinicopathologic features and BRAF(V600E) mutation analysis in cutaneous metastases from well-differentiated thyroid carcinomas. Cancer; 2007 May 15;109(10):1965-71
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  • [Title] Clinicopathologic features and BRAF(V600E) mutation analysis in cutaneous metastases from well-differentiated thyroid carcinomas.
  • BACKGROUND: Cutaneous metastases from well-differentiated thyroid carcinomas are rare and are usually identified in patients with widely disseminated disease.
  • Occasionally, thyroid carcinomas can present as cutaneous metastases for which the primary site needs to be determined.
  • A series of 16 cutaneous metastases were analyzed from well-differentiated thyroid carcinomas to learn more about the clinicopathologic features and BRAF(V600E) mutation status.
  • METHODS: Eleven cases of PTC and 5 of follicular thyroid carcinoma (FTC) metastatic to the skin were evaluated.
  • All cutaneous metastases were studied histologically and with thyroglobulin and thyroid transcription factor immunostains.
  • All tumor samples were analyzed for mutations at nucleotide 1799 in exon 15 of the BRAF gene.
  • RESULTS: Two patients with FTC presented with cutaneous metastases.
  • The histologic features of the cutaneous metastases were generally characteristic of the primary tumor; however, 2 of the 11 PTC metastases demonstrated cytoplasmic clearing not typical of classic PTC.
  • CONCLUSIONS: Cutaneous metastases from PTC may show prominent clear cell change requiring differentiation from clear cell hidradenoma, clear cell dermatofibroma, malignant melanoma with prominent clear cell change, and cutaneous metastasis from renal cell carcinoma.
  • BRAF(V600E) mutation is identified in a subset of cutaneous metastases from PTC.
  • Cutaneous metastases from PTC and FTC are associated with a very poor prognosis.
  • [MeSH-major] Adenocarcinoma, Follicular / genetics. Adenocarcinoma, Follicular / secondary. Carcinoma, Papillary / genetics. Carcinoma, Papillary / secondary. Mutation. Proto-Oncogene Proteins B-raf / genetics. Skin Neoplasms / secondary. Thyroid Neoplasms / genetics

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  • [Copyright] (c) 2007 American Cancer Society
  • (PMID = 17387744.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] EC 2.7.11.1 / BRAF protein, human; EC 2.7.11.1 / Proto-Oncogene Proteins B-raf
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83. Teymoortash A, Schultz ES, Werner JA: [Significance of parotid metastases of squamous cell carcinoma of scalp]. Hautarzt; 2007 Apr;58(4):323-7
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  • [Title] [Significance of parotid metastases of squamous cell carcinoma of scalp].
  • [Transliterated title] Klinische Bedeutung parotidealer Metastasen von Plattenepithelkarzinomen der Kopfhaut.
  • BACKGROUND: The aim of the study was the characterization of patients with metastatic cutaneous squamous cell carcinoma involving the parotid gland.
  • PATIENTS AND METHODS: The clinical, radiological and pathological tumor data of 16 patients with parotid metastasis of a previously treated squamous cell carcinoma of the skin were analyzed retrospectively.
  • RESULTS: Patients over 70 years of age with a primary skin cancer of at least 1.5 centimeter in diameter were defined as the high risk group for development of regional metastasis involving the parotid gland.
  • The time interval between therapy of the skin cancer and detection of the metastatic involvement of the parotid gland was 9.8 (2-24) months on average.
  • The average maximal diameter of the parotid metastasis was 3.2 (1.5-4.9) centimeter at diagnosis.
  • Metastatic infiltration of cervical lymph nodes could be shown in 9 patients and in 2 patients pulmonary metastases were detected.
  • The average survival after parotid metastasis was 11.7 (3-31) months.
  • CONCLUSION: The early diagnosis and therapy of locoregional metastasis from cutaneous squamous cell carcinoma of the scalp have a high prognostic value.
  • High-risk patients with cutaneous squamous cell carcinoma should be followed up sonographically in narrow intervals for detection of parotid and cervical lymph node metastasis.
  • [MeSH-major] Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / diagnosis. Parotid Neoplasms / diagnosis. Parotid Neoplasms / secondary. Scalp. Skin Neoplasms / diagnosis

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  • (PMID = 17237930.001).
  • [ISSN] 0017-8470
  • [Journal-full-title] Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  • [ISO-abbreviation] Hautarzt
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
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84. Petersen RP, Hanish SI, Haney JC, Miller CC 3rd, Burfeind WR Jr, Tyler DS, Seigler HF, Wolfe W, D'Amico TA, Harpole DH Jr: Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma. J Thorac Cardiovasc Surg; 2007 Jan;133(1):104-10
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  • [Title] Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma.
  • OBJECTIVES: The outcomes of patients with metastatic melanoma are poor.
  • Although prognostic models have been developed to predict the occurrence of pulmonary metastasis from cutaneous melanoma, few data exist to define the outcomes of these patients once metastasis has occurred.
  • The objective of this study was to discriminate predictors of survival for patients with pulmonary metastatic melanoma.
  • METHODS: We found 1720 patients with pulmonary metastasis listed in a prospective comprehensive cancer center database of 14,057 consecutive patients with melanoma (Jan 1, 1970-June 1, 2004).
  • Univariate and multivariate Cox proportional hazards models were used to identify predictors of survival for patients with pulmonary metastatic melanoma.
  • RESULTS: The median survival was 7.3 months after development of pulmonary metastasis.
  • Significant predictors of survival from the multivariate model included nodular histologic type (P = .033), disease-free interval (P < .001), number of pulmonary metastases (P = .012), presence of extrathoracic metastasis (P < .001), and performance of pulmonary metastasectomy (P < .001).
  • Interactions were identified between metastasectomy and disease-free interval and presence of extrathoracic metastasis.
  • Surgery was associated with a survival advantage of 12 months for patients with a disease-free interval longer than 5 years (19 vs 7 months, P < .01) and of 10 months for patients without extrathoracic metastasis (18 vs 8 months, P < .01).
  • CONCLUSIONS: When all other identified risk factors were controlled for mathematically, metastasectomy maintained a significant survival advantage for patients with pulmonary metastatic melanoma.
  • These data support the role of surgery for a select subset of patients with pulmonary metastasis.
  • [MeSH-major] Lung Neoplasms / secondary. Lung Neoplasms / surgery. Melanoma / secondary. Melanoma / surgery. Skin Neoplasms / pathology

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  • [CommentIn] J Thorac Cardiovasc Surg. 2007 Oct;134(4):1097 [17903561.001]
  • (PMID = 17198792.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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85. Vankalakunti M, Das A, Rao NK: Postauricular congenital alveolar rhabdomyosarcoma- a case report of an unusual entity. Diagn Pathol; 2006;1:37

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Congenital alveolar rhabdomyosarcoma is an extremely uncommon and invariably fatal tumor with the current therapy.
  • Less than 25% of patients present with evidence of cutaneous metastasis.
  • CONCLUSION: The suspicion of alveolar subtype on histological grounds and proper evaluation of this tumor by immunostain and ultrastuctural examination is necessary.

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  • [Cites] Ann Surg. 1973 Sep;178(3):346-51 [4729757.001]
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  • (PMID = 17044930.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC1621081
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86. Flezar MS, Prevodnik VK, Kirbis IS, Strojan P: Cutaneous squamous cell carcinoma metastatic to chronic lymphocytic leukaemia: diagnostic potential of fine needle aspiration cytology. Cytopathology; 2006 Oct;17(5):288-94
NCI CPTC Antibody Characterization Program. NCI CPTC Antibody Characterization Program .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous squamous cell carcinoma metastatic to chronic lymphocytic leukaemia: diagnostic potential of fine needle aspiration cytology.
  • OBJECTIVE: The phenomenon of cancer-to-cancer metastasis of cutaneous squamous cell carcinoma (SCC) and chronic lymphocytic leukaemia (CLL)/small lymphocytic lymphoma (SLL) is a rare event and only occasionally documented in the medical literature.
  • METHODS: Two patients with SCC of the skin that were previously treated for CLL are presented.
  • In addition, the literature on cutaneous SCC metastatic to CLL/SLL with special emphasis on the role of FNAC in this specific clinical situation was reviewed.
  • RESULTS: On examination of the FNAC smear, cancer-to-cancer metastasis of cutaneous SCC to lymph node replaced by CLL was found.
  • In addition to our two patients, nine cases of cutaneous SCC metastatic to CLL/SLL have been reported in the literature, and in only one was the diagnosis made by FNAC.
  • CONCLUSION: FNAC supported by ancillary immunocytological techniques could also be used in diagnosis of specific clinical situations such as cancer-to-cancer metastasis of the tandem of SCC-CLL/SLL.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Leukemia, Lymphocytic, Chronic, B-Cell / pathology. Neoplasms, Second Primary. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Biopsy, Fine-Needle. Fatal Outcome. Flow Cytometry. Humans. Immunohistochemistry. Immunophenotyping. Lymphatic Metastasis. Male

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  • (PMID = 16961658.001).
  • [ISSN] 0956-5507
  • [Journal-full-title] Cytopathology : official journal of the British Society for Clinical Cytology
  • [ISO-abbreviation] Cytopathology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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87. Adamski H, Le Lan J, Chevrier S, Cribier B, Watier E, Chevrant-Breton J: Primary cutaneous cribriform carcinoma: a rare apocrine tumour. J Cutan Pathol; 2005 Sep;32(8):577-80

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary cutaneous cribriform carcinoma: a rare apocrine tumour.
  • BACKGROUND: Primary cutaneous cribriform carcinoma (PCCC) is a rare apocrine tumour occurring in middle-aged people.
  • This neoplasm is often located on the limbs.
  • The histopathological diagnosis is difficult, mainly because this tumour is exceptional.
  • RESULTS: Histopathologic findings showed an asymmetrical deep dermal tumour with a cribriform pattern.
  • After a 2-year follow-up, neither persistence at the local site nor metastasis was observed.
  • Differential diagnoses, including cutaneous metastasis of adenocarcinoma, adenoid basal cell carcinoma and adenoid cystic carcinoma, are discussed.
  • [MeSH-minor] Adult. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Basal Cell / diagnosis. Diagnosis, Differential. Humans. Male. Treatment Outcome

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  • (PMID = 16115058.001).
  • [ISSN] 0303-6987
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
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88. Mahieu-Renard L, Richard MA, Dales JP, Buscaylet S, Lagrassa S, Grob JJ: [Treatment of cutaneous metastases of a squamous cell carcinoma of the leg with topical miltefosine]. Ann Dermatol Venereol; 2005 Apr;132(4):346-8
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  • [Title] [Treatment of cutaneous metastases of a squamous cell carcinoma of the leg with topical miltefosine].
  • [Transliterated title] Traitement de métastases cutanées d'un carcinome épidermoïde de la jambe par applications de miltéfosine.
  • INTRODUCTION: Miltefosine (Hexadecylphosphocholine) is a chemotherapy, which when applied locally, has demonstrated efficacy in the treatment of cutaneous metastases of breast cancer.
  • CASE REPORT: A 79 year-old woman developed recurrent in transit cutaneous metastases of a squamous cell carcinoma on her left leg.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Squamous Cell / drug therapy. Carcinoma, Squamous Cell / secondary. Neoplasm Recurrence, Local / drug therapy. Phosphorylcholine / analogs & derivatives. Skin Neoplasms / drug therapy. Skin Neoplasms / secondary

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  • (PMID = 15886562.001).
  • [ISSN] 0151-9638
  • [Journal-full-title] Annales de dermatologie et de vénéréologie
  • [ISO-abbreviation] Ann Dermatol Venereol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 107-73-3 / Phosphorylcholine; 53EY29W7EC / miltefosine
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89. Egberts F, Kaehler KC, Brasch J, Schwarz T, Cerroni L, Hauschild A: Multiple skin metastases of malignant melanoma with unusual clinical and histopathologic features in an immunosuppressed patient. J Am Acad Dermatol; 2008 May;58(5):880-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple skin metastases of malignant melanoma with unusual clinical and histopathologic features in an immunosuppressed patient.
  • Whether immunosuppression can also influence the clinical and histopathologic appearance of malignant melanocytic lesions is still a matter of debate.
  • Three months later melanoma metastases were removed from the patient's left axilla, which finally resulted in the death of the patient.
  • Thus, in retrospect, the eruptive pigmented lesions have to be considered as cutaneous melanoma metastases.
  • [MeSH-major] Immunosuppression / adverse effects. Melanoma / secondary. Nevus, Pigmented / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Amyloidosis / complications. Bone Marrow Transplantation / adverse effects. Fatal Outcome. Heart Transplantation / adverse effects. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Papilloma / pathology

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  • (PMID = 18258334.001).
  • [ISSN] 1097-6787
  • [Journal-full-title] Journal of the American Academy of Dermatology
  • [ISO-abbreviation] J. Am. Acad. Dermatol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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90. Martínez-Luna E, Puebla-Miranda M, Vega-Memije ME: [Skin metastasis of gastric adenocarcinoma. Case report]. Rev Gastroenterol Mex; 2009 Oct-Dec;74(4):362-5
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  • [Title] [Skin metastasis of gastric adenocarcinoma. Case report].
  • [Transliterated title] Metástasis cutáneas de adenocarcinoma gástrico; informe de un caso.
  • Incidence of cutaneous metastases of malignant tumors has been estimated between 0.7%-10.8%.
  • These lesions generally occur in late stages of disease, being uncommon their presentation at the time of diagnosis.
  • We inform the case of a male patient who presented a metastatic adenocarcinoma in the skin of the chest.
  • Under the suspect of primary tumor in the gastrointestinal tract, an upper gastrointestinal endoscopy was made corroborating diagnosis of a primary gastric cancer.
  • The case instructs the unusual morphology of cutaneous metastasis of gastric adenocarcinoma, as well appearing as the initial clinical data in an extended malignant disease.
  • Key words: cutaneous metastases, metastatic adenocarcinoma, gastric carcinoma, Mexico.
  • [MeSH-major] Adenocarcinoma / secondary. Skin Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 20423769.001).
  • [ISSN] 0375-0906
  • [Journal-full-title] Revista de gastroenterología de México
  • [ISO-abbreviation] Rev Gastroenterol Mex
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Mexico
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91. Santi R, Massi D, Mazzoni F, Antonuzzo L, Comin CE: Skin metastasis from typical carcinoid tumor of the lung. J Cutan Pathol; 2008 Apr;35(4):418-22
MedlinePlus Health Information. consumer health - Skin Cancer.

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  • [Title] Skin metastasis from typical carcinoid tumor of the lung.
  • We herein describe a rather infrequent case of a 60-year-old man with a skin metastasis from a typical carcinoid of the lung.
  • We discuss the histopathological and immunohistochemical features in the context of previous literature and comment issues related to difficulties in the differential diagnosis.
  • Dermatopathologists should be familiar with the metastatic carcinoid profile in order to avoid potential misdiagnoses and to properly address the patient management when the skin metastasis represents the first manifestation of an internal disease.
  • [MeSH-major] Carcinoid Tumor / secondary. Lung Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Biomarkers, Tumor / analysis. Diagnosis, Differential. Humans. Male. Middle Aged. Sebaceous Gland Neoplasms / diagnosis

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  • (PMID = 18333904.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
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92. Shamsadin S, Esfandiarpoor I, Zeinali H, Kalantari B, Ebrahimi H: Multifocal scalp hair loss. Dermatol Online J; 2006;12(4):24
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • BACKGROUND: Cutaneous metastases from internal cancer are relatively uncommon in clinical practice, but they are very important to recognize.
  • Metastases of skin may be a herald sign in the diagnosis of internal malignancy.
  • Scalp metastasis from breast carcinoma is reported but it is rare.
  • An incision biopsy of an alopecic patch was done revealing metastases of breast carcinoma to the scalp.
  • Her workup failed to find metastatic involvement of other organs.
  • This represents a case of breast carcinoma metastatic to the scalp mimicking alopecia areata, almost 10 years after radical mastectomy, and 8 years after chemotherapy.
  • [MeSH-major] Alopecia Areata / diagnosis. Breast Neoplasms. Carcinoma / secondary. Diagnostic Errors. Head and Neck Neoplasms / secondary. Scalp / pathology. Skin Neoplasms / secondary

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  • (PMID = 17083879.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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93. López-Tarruella Cobo S, Moreno Antón F, Sastre J, López García-Asenjo JA, Torres A, Díaz-Rubio E: Cuirasse skin metastases secondary to gastric adenocarcinoma. Clin Transl Oncol; 2005 Jun;7(5):213-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cuirasse skin metastases secondary to gastric adenocarcinoma.
  • Skin metastases are infrequent manifestations of solid tumours.
  • However, it is important to recognize them since they may be the first evidence of a neoplasia, or a sign of tumour progression or recurrence.
  • Skin metastases from gastric adenocarcinomas are particularly rare, and represent 6% of the total in males and 1% in females.
  • We report, here, the case of a patient diagnosed with gastric adenocarcinoma with extensive subcutaneous infiltration of the abdominal wall, resulting in an abdominal cuirass.
  • [MeSH-major] Adenocarcinoma / secondary. Skin Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Skin / pathology

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  • (PMID = 15960933.001).
  • [ISSN] 1699-048X
  • [Journal-full-title] Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
  • [ISO-abbreviation] Clin Transl Oncol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
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94. de Paula TA, da Silva PS, Berriel LG: Renal cell carcinoma with cutaneous metastasis: case report. J Bras Nefrol; 2010 Apr-Jun;32(2):213-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Renal cell carcinoma with cutaneous metastasis: case report.
  • Renal cell carcinoma or hypernephroma is the third most common neoplasia of the genitourinary tract.
  • Metastases are present at the time of diagnosis in approximately 30% of the patients, the major sites being lungs, bones, skin, liver, and brain.
  • We report the case of a male patient with renal cell carcinoma, whose age, clinical findings, and tumor histological type matched with the most common ones for that pathology.
  • Nevertheless, he already had distant metastasis in an uncommon site at the time of diagnosis.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 21103681.001).
  • [ISSN] 2175-8239
  • [Journal-full-title] Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
  • [ISO-abbreviation] J Bras Nefrol
  • [Language] eng; por
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Brazil
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95. Shimizu H, Maegawa J, Ho T, Yamamoto Y, Mikami T, Nagahama K: Cutaneous metastasis of pancreatic carcinoma as an initial symptom in the lower extremity with obstructive lymphedema treated by physiotherapy and lymphaticovenous shunt: a case report, review, and pathophysiological implications. Lymphology; 2010 Mar;43(1):19-24
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  • [Title] Cutaneous metastasis of pancreatic carcinoma as an initial symptom in the lower extremity with obstructive lymphedema treated by physiotherapy and lymphaticovenous shunt: a case report, review, and pathophysiological implications.
  • Cutaneous metastasis from pancreatic cancer is relatively rare as an initial symptom, and it is generally localized on the periumbilical area that is known as Sister Mary Joseph's nodule.
  • We report a rare case of a 49-year-old female who developed cutaneous metastasis of pancreatic cancer as an initial symptom.
  • The patient was referred to our department for treatment of lymphedema due to surgical treatment of cervical cancer and underwent combined physiotherapy and, 2 months later, a lymph venous anastomosis (LVA) for treatment of the lymphedema.
  • These facts suggest a possible relationship between cutaneous metastasis of carcinoma and treatment for lymphedema.
  • Alternatively, the lymphedematous limb may be a privileged site for cancer growth, and metastatic seeding could have taken place from pre-existing hematogenous spread at the time of operation.
  • [MeSH-major] Lymphatic Vessels / surgery. Lymphedema / therapy. Pancreatic Neoplasms / pathology. Physical Therapy Modalities. Skin Neoplasms / secondary

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  • (PMID = 20552816.001).
  • [ISSN] 0024-7766
  • [Journal-full-title] Lymphology
  • [ISO-abbreviation] Lymphology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 7
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96. Hammers HJ, Verheul HM, Salumbides B, Sharma R, Rudek M, Jaspers J, Shah P, Ellis L, Shen L, Paesante S, Dykema K, Furge K, Teh BT, Netto G, Pili R: Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study. Mol Cancer Ther; 2010 Jun;9(6):1525-35
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Tyrosine kinase inhibitors (TKI) targeting angiogenesis via inhibition of the vascular endothelial growth factor pathway have changed the medical management of metastatic renal cell carcinoma.
  • To address this question, we obtained an excisional biopsy of a skin metastasis from a patient with clear cell renal carcinoma who initially had a response to sunitinib and eventually progressed with therapy.
  • Tumor pieces were grafted s.c. in athymic nude mice.
  • Tumor size, microvascular density, and pericyte coverage were determined.
  • A tumor-derived cell line was established and assessed in vitro for potential direct antitumor effects of sunitinib.
  • More interestingly, histologic examination of the original skin metastasis revealed evidence of epithelial to mesenchymal transition, whereas the xenografts showed reversion to the clear cell phenotype.
  • In vitro studies showed no inhibitory effect on tumor cell growth at pharmacologically relevant concentrations.
  • In conclusion, the histologic examination in this xenograft study suggests that reversible epithelial to mesenchymal transition may be associated with acquired tumor resistance to TKIs in patients with clear cell renal carcinoma.

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  • (PMID = 20501804.001).
  • [ISSN] 1538-8514
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] ENG
  • [Grant] None / None / / P30 CA006973-48; United States / NCRR NIH HHS / RR / S10 RR026824; United States / NCRR NIH HHS / RR / S10 RR026824-01; United States / NCI NIH HHS / CA / P30 CA006973-48
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Indoles; 0 / Protein Kinase Inhibitors; 0 / Pyrroles; 0 / sunitinib; EC 6.3.2.19 / Von Hippel-Lindau Tumor Suppressor Protein
  • [Other-IDs] NLM/ NIHMS274514; NLM/ PMC3049816
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97. Jilani G, Mohamed D, Wadia H, Ramzi K, Meriem J, Houssem L, Samir G, Nawfel BR: Cutaneous metastasis of renal cell carcinoma through percutaneous fine needle aspiration biopsy: case report. Dermatol Online J; 2010;16(2):10
MedlinePlus Health Information. consumer health - Skin Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cutaneous metastasis of renal cell carcinoma through percutaneous fine needle aspiration biopsy: case report.
  • Percutaneous needle biopsy of the lung was performed via the right anterior chest wall and the histologic findings showed metastasis from renal carcinoma.
  • Six month later, the patient presented with a cutaneous nodule at the site of puncture of the lung needle biopsy.
  • Histological examination of a biopsy of the skin tumor revealed features of metastatic renal cell carcinoma of clear cell type.
  • Surgical excision of the cutaneous nodule was performed, followed by radiotherapy at the site of the skin lesion on the chest wall.
  • This case represents an unusual clinical presentation of metastatic renal cell carcinoma that appears to have been translocated to the skin by the needle biopsy.
  • [MeSH-major] Biopsy, Fine-Needle / adverse effects. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Lung Neoplasms / secondary. Neoplasm Seeding. Skin Neoplasms / pathology. Skin Neoplasms / secondary

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  • (PMID = 20178706.001).
  • [ISSN] 1087-2108
  • [Journal-full-title] Dermatology online journal
  • [ISO-abbreviation] Dermatol. Online J.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Cecchi R, Pavesi M, Calamandrei P, Rapicano V, De Gaudio C: Tonsil metastasis from cutaneous melanoma: first clinical sign of recurrence after complete lymph node dissection. J Cutan Med Surg; 2010 Jan-Feb;14(1):43-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Tonsil metastasis from cutaneous melanoma: first clinical sign of recurrence after complete lymph node dissection.
  • BACKGROUND: The development of melanoma metastasis to the palatine tonsil is a very rare event, generally associated with advanced-stage disease and poor prognosis.
  • CASE PRESENTATION: A 29-year-old man presented with a melanoma metastasis to the right palatine tonsil 6 months after the surgical excision of an ulcerated nodular melanoma (tumor thickness 1.8 mm, Clark level IV) on the left shoulder.
  • A metastatic sentinel lymph node had been removed from the left axilla, and a subsequent complete lymph node dissection had disclosed no further metastatic lymph nodes.
  • Although staging tests had revealed multiple visceral metastases, a palliative tonsillectomy was performed.
  • The patient died of metastases 5 months later.
  • [MeSH-major] Melanoma / secondary. Skin Neoplasms / pathology. Tonsillar Neoplasms / secondary
  • [MeSH-minor] Adult. Fatal Outcome. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Neoplasm Recurrence, Local. Tonsillectomy

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  • (PMID = 20128991.001).
  • [ISSN] 1203-4754
  • [Journal-full-title] Journal of cutaneous medicine and surgery
  • [ISO-abbreviation] J Cutan Med Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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99. Karpate SJ, Samal SL, Jain SM: Recurrent ovarian malignancy presenting as cutaneous metastasis. Indian J Dermatol; 2009;54(4):380-1

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Recurrent ovarian malignancy presenting as cutaneous metastasis.
  • Cutaneous metastasis from ovarian carcinoma is relatively uncommon in clinical practice.
  • We report the case of the woman who presented to us with clitoral nodules and skin nodules.
  • Histopathological examination of nodules confirmed the diagnosis of metastasis of an ovarian carcinoma.

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  • [Cites] J Am Acad Dermatol. 1995 Aug;33(2 Pt 1):161-82; quiz 183-6 [7622642.001]
  • [Cites] Gynecol Oncol. 2003 Sep;90(3):670-2 [13678744.001]
  • [Cites] Cutis. 1994 Nov;54(5):348-50 [7835065.001]
  • [Cites] Gynecol Oncol. 2003 Sep;90(3):682-5 [13678747.001]
  • (PMID = 20101345.001).
  • [ISSN] 1998-3611
  • [Journal-full-title] Indian journal of dermatology
  • [ISO-abbreviation] Indian J Dermatol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC2807720
  • [Keywords] NOTNLM ; Skin metastasis / ovarian carcinoma / prognosis
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100. Katsourakis A, Noussios G, Alatsakis M, Chatzis I, Chatzitheoklitos E: Primary malignant melanoma of the small intestine: a case report. Acta Chir Belg; 2009 May-Jun;109(3):405-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Primary malignant melanoma of the small intestine: a case report.
  • The small intestine is the most common site of gastro-intestinal metastasis from cutaneous malignant melanoma.
  • We report a case of a 71-year-old man with a primary malignant melanoma in the jejunum.
  • This diagnosis was confirmed at laparotomy.
  • A primary malignant melanoma of the small intestine is an extremely rare neoplasm.
  • A definite diagnosis can only be made after a thorough investigation has been made to exclude the co-existence of a primary lesion elsewhere.
  • [MeSH-major] Jejunal Neoplasms / diagnosis. Laparotomy / methods. Melanoma / diagnosis
  • [MeSH-minor] Aged. Diagnosis, Differential. Endoscopy, Gastrointestinal / methods. Follow-Up Studies. Humans. Male. Tomography, X-Ray Computed

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  • (PMID = 19943602.001).
  • [ISSN] 0001-5458
  • [Journal-full-title] Acta chirurgica Belgica
  • [ISO-abbreviation] Acta Chir. Belg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Belgium
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