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Items 1 to 55 of about 55
25. Bulbul Y, Oztuna F, Topba M, Ozlu T: Survival analyses of patients with thoracic complications secondary to bronchial carcinoma at the time of diagnosis. Respiration; 2005 Jul-Aug;72(4):388-94
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  • [Title] Survival analyses of patients with thoracic complications secondary to bronchial carcinoma at the time of diagnosis.
  • BACKGROUND: The impact on survival of thoracic complications secondary to bronchial carcinoma has not been clearly analyzed.
  • OBJECTIVES: The purpose of this study was to assess the significance of these complications for the survival of lung cancer patients.
  • Any intrathoracic change or abnormality secondary to bronchial carcinoma such as atelectasis or pleural effusion was defined a thoracic complication.
  • The complications were atelectasis, pulmonary metastases, pleural effusion, laryngeal nerve involvement, vena cava superior syndrome and others.
  • CONCLUSION: Atelectasis, which was determined to be the most frequent thoracic complication, was identified as a favorable prognostic factor in patients with advanced stage lung cancer.

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  • [Copyright] (c) 2005 S. Karger AG, Basel.
  • (PMID = 16088282.001).
  • [ISSN] 0025-7931
  • [Journal-full-title] Respiration; international review of thoracic diseases
  • [ISO-abbreviation] Respiration
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Switzerland
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26. Cohen-Mouly S, Badia A, Bats AS, Barthes F, Bensaïd C, Riquet M, Lécuru F: Role of video-assisted thoracoscopy in patients with ovarian cancer and pleural effusion. Int J Gynecol Cancer; 2009 Dec;19(9):1662-5
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  • [Title] Role of video-assisted thoracoscopy in patients with ovarian cancer and pleural effusion.
  • OBJECTIVES: To evaluate the feasibility of video-assisted thoracoscopy (VAT) for staging advanced ovarian cancer, to measure the performance of preoperative computed tomography (CT) for diagnosing pleural metastases, to assess the correlation between pleural and abdominal involvement, and to measure the impact of VAT on patient management.
  • METHODS: We retrospectively evaluated 16 VAT procedures in 15 patients with advanced ovarian malignancies and pleural effusions.
  • The reason for VAT was either to evaluate unilateral or bilateral pleural effusions (n = 15) or to evaluate pleural metastases after neoadjuvant chemotherapy (n = 1).
  • The rates of involvement of the hepatic pedicle, mesentery, and right side of the diaphragm were compared with the rate of pleural involvement.
  • Video-assisted thoracoscopy identified metastases smaller than 1 cm in 5 patients and larger than 1 cm in 2 additional patients; there was no evidence of pleural involvement in 6 patients.
  • Computed tomography had 14% sensitivity and 25% specificity for pleural status determination, using VAT biopsy as the reference standard.
  • Pleural involvement did not correlate with involvement of the hepatic pedicle, mesentery, or right side of the diaphragm.
  • CONCLUSIONS: Video-assisted thoracoscopy performs better than CT for evaluating pleural involvement in ovarian cancer.
  • [MeSH-major] Carcinoma / surgery. Ovarian Neoplasms / surgery. Pleural Effusion, Malignant / diagnosis. Thoracic Surgery, Video-Assisted
  • [MeSH-minor] Aged. Biopsy, Needle. Disease Progression. Feasibility Studies. Female. Humans. Middle Aged. Neoplasm Staging / methods. Pleural Neoplasms / diagnosis. Pleural Neoplasms / secondary. Pleural Neoplasms / surgery. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 19955956.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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27. Soria G, Yaal-Hahoshen N, Azenshtein E, Shina S, Leider-Trejo L, Ryvo L, Cohen-Hillel E, Shtabsky A, Ehrlich M, Meshel T, Keydar I, Ben-Baruch A: Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions. Cytokine; 2008 Oct;44(1):191-200
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  • [Title] Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions.
  • In the present study, we asked if the two chemokines are jointly expressed in clinical samples of breast cancer patients, and do they interact in breast tumor cells.
  • We found that RANTES and MCP-1 were expressed by breast tumor cells in primary tumors of Ductal Carcinoma In Situ and of Invasive Ductal Carcinoma, but minimally in normal breast epithelial duct cells.
  • The chemokines were also detected in metastases and pleural effusions.
  • Novel findings showed that co-expression of RANTES and MCP-1 in the same tumor was associated with more advanced stages of disease, suggesting that breast tumors "benefit" from interactions between the two chemokines.
  • Our findings show a chemokine-triggered release of stored pro-malignancy chemokine from breast tumor cells.
  • These observations support a major tumor-promoting role for co-expression of the chemokines in breast malignancy, and agree with the significant association of joint RANTES and MCP-1 expression with advanced stages of breast cancer.
  • [MeSH-minor] Carcinoma, Ductal, Breast / metabolism. Carcinoma, Ductal, Breast / pathology. Carcinoma, Intraductal, Noninfiltrating / metabolism. Carcinoma, Intraductal, Noninfiltrating / pathology. Cell Line, Tumor. Female. Gene Expression Regulation, Neoplastic. Humans. Neoplasm Metastasis / physiopathology. Pleural Effusion / metabolism

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  • (PMID = 18790652.001).
  • [ISSN] 1096-0023
  • [Journal-full-title] Cytokine
  • [ISO-abbreviation] Cytokine
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CCL2 protein, human; 0 / CCL5 protein, human; 0 / Chemokine CCL2; 0 / Chemokine CCL5
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28. Kamiyoshihara M, Ibe T, Takise A, Itou H, Takeyoshi I: Pleural metastases from renal cell carcinoma 16 years after resection. J Clin Oncol; 2007 Sep 1;25(25):4009-11
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  • [Title] Pleural metastases from renal cell carcinoma 16 years after resection.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / surgery. Pleural Neoplasms / diagnosis. Pleural Neoplasms / secondary

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  • (PMID = 17761985.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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29. Iankov ID, Msaouel P, Allen C, Federspiel MJ, Bulur PA, Dietz AB, Gastineau D, Ikeda Y, Ingle JN, Russell SJ, Galanis E: Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer model. Breast Cancer Res Treat; 2010 Aug;122(3):745-54
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  • [Title] Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer model.
  • Breast cancer is the second leading cause of malignant effusions in cancer patients.
  • Pleural effusion indicates incurable disease with limited palliative treatment options and poor outcome.
  • Here, we demonstrate the therapeutic efficacy of measles virus (MV) vaccine strain derivative against malignant pleural effusion in an MDA-MB-231 xenograft model of advanced breast cancer.
  • Both systemic intravenous (i.v.) and intrapleural (t.t.) administered virus caused massive infection and syncytia formation in the pleural tumor deposits.
  • Furthermore, we tested human dendritic cells as carriers for delivery of oncolytic MV infection to breast cancer pleural metastases.
  • Carrier-delivered MV infection prevented accumulation of the pleural exudate and also significantly improved the survival of the treated mice.
  • This is the first demonstration of the therapeutic potential of oncolytic virotherapy against malignant pleural effusions in a pre-clinical model of advanced breast cancer.

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  • (PMID = 19894113.001).
  • [ISSN] 1573-7217
  • [Journal-full-title] Breast cancer research and treatment
  • [ISO-abbreviation] Breast Cancer Res. Treat.
  • [Language] ENG
  • [Grant] United States / NCI NIH HHS / CA / P50 CA108961; United States / NCI NIH HHS / CA / P50 CA116201-010005; United States / NCI NIH HHS / CA / P50 CA116201; United States / NCI NIH HHS / CA / P50CA108961; United States / NCI NIH HHS / CA / CA116201-010005
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0 / Measles Vaccine
  • [Other-IDs] NLM/ NIHMS228888; NLM/ PMC2935656
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30. Chen JL, Chen KY, Lin CJ, Perng WC, Chen JH: Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus. Hematol Oncol Stem Cell Ther; 2010;3(1):47-50
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  • [Title] Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus.
  • Transformation of a poorly differentiated squamous cell carcinoma (SCC) of the esophagus into a âcarcinosarcomaâ of the pleura and lung has never been reported and its histogenetic origin is still debated.
  • About 9 months later, rapid progression of lung metastases and pleural effusion were found.
  • Palliative therapy was given and the patient eventually died of the disease 9 months after SCC of the thoracic esophagus was diagnosed and one month after carcinosarcoma of the pleura and lung were confirmed.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Carcinosarcoma / diagnosis. Carcinosarcoma / secondary
  • [MeSH-minor] Esophageal Neoplasms / pathology. Fatal Outcome. Humans. Lung Neoplasms / secondary. Male. Middle Aged. Palliative Care. Pleural Neoplasms / secondary

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  • (PMID = 20231814.001).
  • [ISSN] 1658-3876
  • [Journal-full-title] Hematology/oncology and stem cell therapy
  • [ISO-abbreviation] Hematol Oncol Stem Cell Ther
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Saudi Arabia
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31. An Z, Dobra K, Lock JG, Strömblad S, Hjerpe A, Zhang H: Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration. Int J Cancer; 2010 Nov 1;127(9):1999-2008
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  • [Title] Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration.
  • Focal adhesion proteins control cytoskeleton dynamics and promote cancer cell growth, survival, migration and metastasis.
  • Little is known, however, about expression of Kindlin-2 in association with human cancer.
  • We now reveal high Kindlin-2 expression in malignant mesothelioma (MM) cell lines using an affinity-purified anti-Kindlin-2 antibody.
  • In addition, Kindlin-2 expression correlates to cell proliferation, suggesting a role for Kindlin-2 in tumor growth.
  • Besides the high expression of Kindlin-2 in pleural MMs, pleural metastases of lung adenocarcinoma also express large amounts of Kindlin-2, but not Kindlin-1.
  • Overall, our study suggests that heightened expression of Kindlin-2 might contribute to tumor progression in MM.
  • [MeSH-major] Lung Neoplasms / metabolism. Membrane Proteins / metabolism. Mesothelioma / metabolism. Neoplasm Proteins / metabolism. Pleural Neoplasms / metabolism
  • [MeSH-minor] Cell Adhesion. Cell Line, Tumor. Cell Movement. Cell Proliferation. Disease Progression. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Protein-Serine-Threonine Kinases / metabolism

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  • (PMID = 20127858.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / FERMT1 protein, human; 0 / MIG2B protein, human; 0 / Membrane Proteins; 0 / Neoplasm Proteins; EC 2.7.1.- / integrin-linked kinase; EC 2.7.11.1 / Protein-Serine-Threonine Kinases
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32. Shao YY, Hong RL: Pleural metastases as a unique entity with dismal outcome of head and neck squamous cell carcinoma. Oral Oncol; 2010 Sep;46(9):694-7
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  • [Title] Pleural metastases as a unique entity with dismal outcome of head and neck squamous cell carcinoma.
  • Once distant metastasis occurs, head and neck squamous cell carcinoma (HNSCC) patients generally have a poor prognosis with limited treatment options.
  • A subgroup of patients who developed pleural metastases after curative treatment of localized HNSCC appeared to have worse outcomes.
  • All patients from National Taiwan University Hospital who were diagnosed with localized HNSCC from January 1, 2000 to December 31, 2007 and developed distant metastases were included in this analysis.
  • Patients with pleura as the first metastatic sites were compared to those with other first metastases for differences in basic demographics, time to distant metastasis (TTM) and overall survival (OS).
  • A total of 198 patients were included, and 52 (26%) had pleural involvement at first diagnosis of distant metastases.
  • Younger age at diagnosis (P=0.002) and buccal mucosa origin (P=0.006) were risk factors for developing pleural metastases.
  • Patients with pleura as the first metastatic sites, compared to those with other first metastases, had significantly shorter TTM (median 7.5 vs. 11.1 months, P<0.001) and OS (median 9.6 vs. 16.5 months, P<0.001).
  • By multivariate analysis, pleural metastases remained an independent predictor for shorter OS.
  • In conclusion, patients with pleural metastases comprise a unique subgroup of HNSCC which rapidly develop distant metastases with poor prognosis.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Head and Neck Neoplasms / pathology. Pleural Neoplasms / secondary
  • [MeSH-minor] Female. Humans. Lymphatic Metastasis. Male. Medical Records. Middle Aged. Prognosis. Retrospective Studies. Risk Factors. Taiwan

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  • [Copyright] Copyright 2010 Elsevier Ltd. All rights reserved.
  • (PMID = 20739213.001).
  • [ISSN] 1879-0593
  • [Journal-full-title] Oral oncology
  • [ISO-abbreviation] Oral Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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33. Mori T, Yoshioka M, Iwatani K, Kobayashi H, Yoshimoto K, Nomori H: Kissing pleural metastases from metastatic osteosarcoma of the lung. Ann Thorac Cardiovasc Surg; 2006 Apr;12(2):129-32
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  • [Title] Kissing pleural metastases from metastatic osteosarcoma of the lung.
  • Two patients with osteosarcoma lung metastases of which migrated to the parietal pleura due to contact are reported.
  • The first patient was a 16-year-old male who had a pleural metastasis in the diaphragm within an area in contact with a single lung metastasis.
  • Nine months after the resection of the first metastases, two other lung metastases were found which were resected after chemotherapy.
  • The patient is alive without recurrence 84 months after the first resection of the metastases.
  • The second patient was an 11-year-old female with a pleural metastasis of osteosarcoma which was within an area in contact with a single lung metastasis, which had been resected 4 months before.
  • We concluded (1) that a lung metastasis of osteosarcoma occasionally metastasizes to the pleura due to contact; and (2) that because this kissing metastases of osteosarcoma could be cured by a complete resection, the intrathoracic cavity should be thoroughly observed.
  • [MeSH-major] Bone Neoplasms / pathology. Lung Neoplasms / secondary. Osteosarcoma / pathology. Pleural Neoplasms / secondary
  • [MeSH-minor] Adolescent. Antineoplastic Agents / therapeutic use. Child. Female. Femur / pathology. Humans. Male. Neoplasm Metastasis. Treatment Outcome

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  • (PMID = 16702936.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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4. Andre F, Cabioglu N, Assi H, Sabourin JC, Delaloge S, Sahin A, Broglio K, Spano JP, Combadiere C, Bucana C, Soria JC, Cristofanilli M: Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Ann Oncol; 2006 Jun;17(6):945-51
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  • [Title] Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer.
  • BACKGROUND: Recent studies have suggested that chemokine receptors are involved in development of organ-specific pattern of metastases.
  • In the present study, we evaluated the association between the chemokine receptors expressed in primary tumor cells and the site of metastatic relapse in patients with breast cancer.
  • METHODS: Primary tumors were obtained from 142 patients with axillary node-positive breast cancer and stained for CX3CR1, CXCR4, CCR6, and CCR7 expression.
  • By estimating the Mantel-Haenszel odds ratios (OR), CXCR4 was associated with increased risk of metastasis to the liver (OR = 3.71, P = 0.005), CX3CR1 was associated with metastasis to the brain (OR = 13.18, P = 0.01).
  • Patients with CCR6 positivity were more likely to develop a first metastasis in the pleura (OR = 2.82, P = 0.06).
  • In addition, CCR7 expression was associated with the occurrence of skin metastases (11% versus 0%, P = 0.017).
  • INTERPRETATION: Expression of chemokine receptors in the primary tumor predicts the site of metastatic relapse in patients with axillary node positive breast cancer.

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  • (PMID = 16627550.001).
  • [ISSN] 0923-7534
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers; 0 / Receptors, Chemokine; 0 / Receptors, Estrogen; EC 2.7.10.1 / Receptor, ErbB-2
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35. Muljono A, Ng T, McMaster J, Dexter M: Choroid plexus metastases from pleural sarcomatoid mesothelioma. Pathology; 2008 Aug;40(5):530-2
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  • [Title] Choroid plexus metastases from pleural sarcomatoid mesothelioma.
  • [MeSH-major] Choroid Plexus Neoplasms / secondary. Mesothelioma / secondary. Pleural Neoplasms / pathology
  • [MeSH-minor] Aged. Brain Neoplasms / pathology. Diagnosis, Differential. Humans. Immunohistochemistry. Magnetic Resonance Imaging. Male

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  • (PMID = 18604744.001).
  • [ISSN] 0031-3025
  • [Journal-full-title] Pathology
  • [ISO-abbreviation] Pathology
  • [Language] eng
  • [Publication-type] Case Reports; Letter
  • [Publication-country] England
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36. Hung HC, Ou HY, Huang JS, Chuang MC, Wu TJ: Tumor-associated Hypercalcemia in a patient with Paget's disease. Kaohsiung J Med Sci; 2008 Mar;24(3):152-6
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  • [Title] Tumor-associated Hypercalcemia in a patient with Paget's disease.
  • After analysis of tumor markers and imaging studies, a clinical diagnosis of pancreatic adenocarcinoma with multiple hepatic and lung metastases with pleural effusion was made.

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  • (PMID = 18364276.001).
  • [ISSN] 1607-551X
  • [Journal-full-title] The Kaohsiung journal of medical sciences
  • [ISO-abbreviation] Kaohsiung J. Med. Sci.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China (Republic : 1949- )
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37. Salloum H, Locher C, Kassem M, Grivaux M, Glikmanas M, Locher C: [Malignant pleural effusions of pancreatic carcinoma]. Gastroenterol Clin Biol; 2006 Jan;30(1):156-7
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  • [Title] [Malignant pleural effusions of pancreatic carcinoma].
  • [Transliterated title] Métastases pleurales d'un adénocarcinome pancréatique.
  • [MeSH-major] Adenocarcinoma / pathology. Pancreatic Neoplasms / pathology. Pleural Effusion, Malignant / etiology

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  • (PMID = 16514403.001).
  • [ISSN] 0399-8320
  • [Journal-full-title] Gastroentérologie clinique et biologique
  • [ISO-abbreviation] Gastroenterol. Clin. Biol.
  • [Language] fre
  • [Publication-type] Case Reports; Letter
  • [Publication-country] France
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38. Debevec L, Erzen J, Debeljak A, Crnjac A, Kovac V: Exploratory thoracotomy and its influence on the survival of patients with lung cancer. Wien Klin Wochenschr; 2006 Aug;118(15-16):479-84
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  • [Title] Exploratory thoracotomy and its influence on the survival of patients with lung cancer.
  • PURPOSE: To evaluate diagnostic procedures, reasons for exploratory thoracotomy (ET), causes of unresectability of lung cancer, possibility for reducing numbers of ETs, and the influence of ET on survival.
  • PATIENTS AND METHODS: Between 1990 and 1999, 1808 patients with lung cancer were operated on.
  • The clinical stages were: three patients in stage IA, 28 in IB, one in IIA, 35 in IIB, 50 in IIIA, 10 in IIIB (all due to invasion of the mediastinum), and four patients in IV (three with ipsilateral pulmonary and one with solitary suprarenal metastasis).
  • The reasons for ET were: diagnosis of preoperatively unverified tumor in one patient, necessity for pneumonectomy in the case of poor pulmonary function in 11 patients, and unresectability in 119 (due to invasion of the mediastinum in 98 patients, thoracic wall in three and vertebral body in one, and due to pleural metastases in 17 patients).
  • [MeSH-minor] Adrenal Gland Neoplasms / secondary. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Lung / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Radiography, Thoracic. Survival Analysis. Tomography, X-Ray Computed

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  • (PMID = 16957979.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Austria
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39. Shitara K, Munakata M, Ishiguro A, Kudo T, Okada R, Tomioka R, Mitobe S, Yokoyama S, Sakata Y: [Colonic perforation in a patient treated with combination chemotherapy for recurrent ovarian clear cell adenocarcinoma]. Gan To Kagaku Ryoho; 2006 Oct;33(10):1497-1500
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  • Emergency laparotomy was not performed because of poor performance status with multiple lung metastases, pleural effusion and pericardial effusion.
  • Oral intake could be restarted for a while, but she died from tumor progression one and a half months after the diagnosis of perforation.
  • [MeSH-major] Adenocarcinoma, Clear Cell / drug therapy. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Cecal Diseases / etiology. Intestinal Perforation / etiology. Neoplasm Recurrence, Local / drug therapy. Ovarian Neoplasms / drug therapy
  • [MeSH-minor] Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Colonoscopy. Drainage. Drug Administration Schedule. Fatal Outcome. Female. Humans. Lung Neoplasms / secondary. Middle Aged. Pleural Effusion, Malignant / etiology

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  • (PMID = 17033246.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 7673326042 / irinotecan; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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40. Suchak AA, Millo N, MacEwan R, McEwan AJ: Neuroendocrine differentiated breast carcinoma with pleural metastases using indium-111 octreotide. Clin Nucl Med; 2009 Feb;34(2):74-5
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  • [Title] Neuroendocrine differentiated breast carcinoma with pleural metastases using indium-111 octreotide.
  • [MeSH-major] Breast Neoplasms / diagnosis. Breast Neoplasms / pathology. Carcinoma, Neuroendocrine / diagnosis. Carcinoma, Neuroendocrine / pathology. Neoplasm Metastasis / diagnosis. Octreotide / analogs & derivatives

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  • (PMID = 19352254.001).
  • [ISSN] 1536-0229
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / indium-111-octreotide; RWM8CCW8GP / Octreotide
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41. Amin RM, Hiroshima K, Kokubo T, Nishikawa M, Narita M, Kuroki M, Nakatani Y: Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report. Respirology; 2006 Nov;11(6):818-25
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  • Pulmonary epithelioid haemangioendothelioma (PEH) is a rare pulmonary neoplasm.
  • A patient with PEH with lymph node and pleural metastases that were discovered incidentally is described.
  • Transbronchial lung biopsy did not provide a diagnosis.
  • The histological diagnosis of PEH was confirmed immunohistochemically by positive reactions to factor VIII-related antigen and CD34.
  • It revealed that male, symptomatic patients, presence of cough, haemoptysis, chest pain, multiple unilateral nodules, pleural effusion, metastases to more than one site and lymph node metastases were all significant risk factors for PEH (P<0.05).
  • Symptomatic patients and presence of pleural effusion were the independent predictors of survival in patients with PEH.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / diagnosis. Hemangioendothelioma, Epithelioid / mortality. Lung Neoplasms / diagnosis. Lung Neoplasms / mortality

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  • (PMID = 17052315.001).
  • [ISSN] 1323-7799
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Antigens, CD34; 0 / Antigens, CD44; 0 / von Willebrand Factor
  • [Number-of-references] 69
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42. Tatsuta M, Iishi H, Baba M, Uedo N, Ishihara R, Higashino K, Mukai M, Ishiguro S: Induction by lysophosphatidic acid of peritoneal and pleural metastases of intestinal cancers induced by azoxymethane in Wistar rats. Cancer Lett; 2005 Mar 10;219(2):137-45
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  • [Title] Induction by lysophosphatidic acid of peritoneal and pleural metastases of intestinal cancers induced by azoxymethane in Wistar rats.
  • The effects of 1-oleoyl lysophosphatidic acid on the induction of metastasis from intestinal adenocarcinomas induced in rats by azoxymethane and on RhoA activity in the tumors were investigated in male Wistar rats.
  • Lysophosphatidic acid at both dosages significantly increased the incidence of peritoneal metastasis.
  • Its administration at higher dosage also significantly enhanced the development of pleural metastasis.
  • Our findings indicate that lysophosphatidic acid significantly increased the incidence of peritoneal and/or pleural metastases from intestinal adenocarcinomas induced in rats by azoxymethane through RhoA activation.
  • [MeSH-major] Adenocarcinoma / secondary. Intestinal Neoplasms / chemically induced. Lysophospholipids / pharmacology. Peritoneal Neoplasms / secondary. Pleural Neoplasms / secondary. rhoA GTP-Binding Protein / metabolism

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  • (PMID = 15723712.001).
  • [ISSN] 0304-3835
  • [Journal-full-title] Cancer letters
  • [ISO-abbreviation] Cancer Lett.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Carcinogens; 0 / Lysophospholipids; 0 / Proliferating Cell Nuclear Antigen; 22002-87-5 / lysophosphatidic acid; EC 3.6.5.2 / rhoA GTP-Binding Protein; MO0N1J0SEN / Azoxymethane
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43. Decroisette C, Melloni B, Moldovan D, Gazaille V, Fermeaux V, Bertin F, Bonnaud F: [Pleural metastases of sclerosing epithelioid fibrosarcoma]. Rev Pneumol Clin; 2006 Jun;62(3):179-82
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  • [Title] [Pleural metastases of sclerosing epithelioid fibrosarcoma].
  • [Transliterated title] Métastases pleurales d'un fibrosarcome épithélioïde sclérosant.
  • Sclerosing epithelioid fibrosarcoma is a rare tumor recently described.
  • Metastatic spread is usually late in the natural course of the disease.
  • We report a case of recurrent sclerosing epithelioid fibrosarcoma with pleural metastases which developed ten years after surgical resection of the primary tumor.
  • The tumor was formed by small uniform round epithelioid cells with a clear cytoplasm.
  • The tumor cells were strongly positive for vimentin.
  • [MeSH-major] Fibrosarcoma / secondary. Pleural Neoplasms / secondary. Soft Tissue Neoplasms / pathology

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  • (PMID = 16840996.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Vimentin
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44. Klee H, Vestring T, Bittmann I: [Pleural metastases of a typical bronchial carcinoid 7 years after lobectomy]. Pneumologie; 2008 Oct;62(10):607-10
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  • [Title] [Pleural metastases of a typical bronchial carcinoid 7 years after lobectomy].
  • [Transliterated title] Pleurales Rezidiv eines typischen pulmonalen Karzinoids 7 Jahre nach Operation.
  • BACKGROUND: Bronchial carcinoids are a rare differential diagnosis of solitary pulmonary nodes.
  • Typically metastases develop in the lung, liver, brain, bone and adrenal glands.
  • CASE REPORT: Seven years after lobectomy of a bronchial carcinoid, a slow-growing thickening of the pleura parietalis was noted in a 54-year-old male patient.
  • The histological diagnosis of pleural metastases was established via trans-thoracic punctation.
  • Pleural metastases of bronchial carcinoids are extremely rare.
  • Metastatic disease--as in the rare case of pleural metastases shown here--remains a therapeutic dilemma.
  • [MeSH-major] Bronchial Neoplasms / diagnosis. Bronchial Neoplasms / surgery. Pleural Neoplasms / diagnosis. Pleural Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Humans. Lymphatic Metastasis. Male. Middle Aged

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  • (PMID = 18711695.001).
  • [ISSN] 1438-8790
  • [Journal-full-title] Pneumologie (Stuttgart, Germany)
  • [ISO-abbreviation] Pneumologie
  • [Language] ger
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Germany
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45. Wilcox BE, Subramaniam RM, Peller PJ, Aughenbaugh GL, Nichols Iii FC, Aubry MC, Jett JR: Utility of integrated computed tomography-positron emission tomography for selection of operable malignant pleural mesothelioma. Clin Lung Cancer; 2009 Jul;10(4):244-8
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  • [Title] Utility of integrated computed tomography-positron emission tomography for selection of operable malignant pleural mesothelioma.
  • BACKGROUND: Malignant pleural mesothelioma (MPM) is a primary malignancy characterized by local invasion of the pleura and metastasis.
  • MATERIALS AND METHODS: Mayo Clinic databases were queried to identify cases with a histologic diagnosis of MPM from 2000 to 2006.
  • Inclusion criteria were a diagnosis of MPM, an available CT scan, and an initial staging integrated CT-PET scan.
  • A total of 35 patients were identified who met the inclusion criteria.
  • The Mayo Clinic tumor registry and Social Security database were queried for survival data in patients in which no follow-up was available.
  • CONCLUSION: Malignant pleural mesothelioma is a difficult disease to accurately stage.
  • The most common reason for upstaging in our series was an increase in T (tumor; tumor-node-metastasis staging system) disease.
  • Our data suggest that integrated CT-PET is excellent for detecting nodal and distant metastases.
  • [MeSH-major] Mesothelioma / radionuclide imaging. Pleural Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm Staging / methods. Radiopharmaceuticals. Retrospective Studies. Sensitivity and Specificity


46. Khadse P, Prabhash K, Pramesh CS, Chaturvedi P, Shet T: Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma. Diagn Cytopathol; 2009 Sep;37(9):680-5
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  • [Title] Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma.
  • Malignant mixed tumor of the parotid is known to have odd sites for metastases.
  • We describe the fine-needle aspiration cytology (FNAC) findings of pleural metastasis from a malignant mixed tumor misdiagnosed as a mesothelioma on cytology at the onset.A 47-year-old man presented to us with breathlessness and a massive pleural effusion with pleural-based nodules.
  • FNAC from the pleural lesions showed myxoid background substance with entrapped cuboidal epithelial cells with atypical nuclei, which were interpreted as mesothelial cells.
  • These cells in contrast to the usual mesothelial cells were not arranged in sheets but rather were huddled in places and formed a pseudoacinar pattern and blended with the myxoid substance.After the diagnosis of a mesothelioma, patient received pemetrexed and cisplatin based chemotherapy with partial response.
  • While on chemotherapy tumor recurred at the primary site in parotid and was confirmed to be a carcinosarcoma on a FNAC and biopsy.To conclude, pleural metastases from a true malignant mixed tumor of the parotid gland can be misdiagnosed as mesothelioma and could occur in the absence of uncontrolled disease at primary site.
  • Both mesotheliomas and pleomorphic adenomas metastatic to the pleura are biphasic tumors, but in a patient with history of pleomorphic adenoma, the latter should be kept as a foremost possibility.
  • Attention to the cytomorphology of tumor cells will also assist in confirming the diagnosis.
  • [MeSH-major] Carcinosarcoma / secondary. Mesothelioma / pathology. Neoplasms, Complex and Mixed / secondary. Parotid Neoplasms / pathology. Pleural Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle. Cisplatin / administration & dosage. Diagnosis, Differential. Diagnostic Errors. Glutamates / administration & dosage. Guanine / administration & dosage. Guanine / analogs & derivatives. Humans. Male. Middle Aged. Neoplasm Recurrence, Local / pathology. Pemetrexed. Pleural Effusion, Malignant / etiology

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  • [Copyright] 2009 Wiley-Liss, Inc.
  • (PMID = 19373913.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Glutamates; 04Q9AIZ7NO / Pemetrexed; 5Z93L87A1R / Guanine; Q20Q21Q62J / Cisplatin
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47. Duysinx BC, Larock MP, Nguyen D, Corhay JL, Bury T, Hustinx R, Louis R: 18F-FDG PET imaging in assessing exudative pleural effusions. Nucl Med Commun; 2006 Dec;27(12):971-6
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  • [Title] 18F-FDG PET imaging in assessing exudative pleural effusions.
  • BACKGROUND: This study evaluates the accuracy of [F]fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging with semi-quantitative analysis for differentiating benign from malignant pleural exudates and for guiding the search for the primary tumour of pleural metastases.
  • Thoracoscopy was systematically performed to reveal pathological diagnosis.
  • RESULTS: All SUVs were significantly higher in all malignant pleural diseases (n = 51) than in benign (n = 28) (P < 0.001).
  • Moreover SUVs were greater in the pleural metastases from pulmonary primaries (n = 25) and in mesotheliomas (n = 8) than in extrathoracic primaries (n = 18) (P < 0.01) with no significant difference between lung cancers and mesotheliomas.
  • Receiver operating curve (ROC) analysis between benign and malignant lesions showed areas under the curves that ranged from 0.803 (SUVbsa g) to 0.863 (SUVbw).
  • CONCLUSION: Semi-quantitative analysis of 18F-FDG PET imaging helps to differentiate malignant from benign pleural exudates and to distinguish between thoracic or extrathoracic primaries.
  • [MeSH-major] Exudates and Transudates / radionuclide imaging. Fluorodeoxyglucose F18. Pleural Effusion / radionuclide imaging. Pleural Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods

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  • (PMID = 17088683.001).
  • [ISSN] 0143-3636
  • [Journal-full-title] Nuclear medicine communications
  • [ISO-abbreviation] Nucl Med Commun
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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48. Mizuta N, Sakaguchi K, Mizuta M, Ichida M, Ohashi M, Umeda Y, Nishiyama A, Matsumoto M, Fujiwara I: [Long-term complete response in a patient with breast cancer and bone and pleura metastases after treatment with a combination of S-1 and zoledronic acid]. Gan To Kagaku Ryoho; 2010 Jul;37(7):1317-20
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  • [Title] [Long-term complete response in a patient with breast cancer and bone and pleura metastases after treatment with a combination of S-1 and zoledronic acid].
  • We report a long-term complete response (CR) in a patient with postoperative recurrent breast cancer and bone and pleura metastases after treatment with a combination of S-1 and zoledronic acid.
  • However, combination therapy with S-1 and zoledronic acid was started because of the development of bone and pleura metastases.
  • After 3 cycles of treatment, the patient's tumor marker levels had decreased to normal values, and both the bone and pleura metastases had disappeared.
  • [MeSH-major] Bone Density Conservation Agents / therapeutic use. Bone Neoplasms / drug therapy. Breast Neoplasms / drug therapy. Diphosphonates / therapeutic use. Imidazoles / therapeutic use. Oxonic Acid / therapeutic use. Pleural Neoplasms / drug therapy. Tegafur / therapeutic use
  • [MeSH-minor] Biomarkers, Tumor / blood. Drug Combinations. Humans. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 20647717.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Bone Density Conservation Agents; 0 / Diphosphonates; 0 / Drug Combinations; 0 / Imidazoles; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 6XC1PAD3KF / zoledronic acid
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49. Kim TJ, Lee KH, Kim YH, Sung SW, Jheon S, Cho SK, Lee KW: Postoperative imaging of esophageal cancer: what chest radiologists need to know. Radiographics; 2007 Mar-Apr;27(2):409-29
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  • [Title] Postoperative imaging of esophageal cancer: what chest radiologists need to know.
  • A variety of surgical procedures are used in the treatment of esophageal cancer.
  • Although meticulous surgical techniques and improved postoperative care have markedly reduced the complications associated with these techniques, esophageal resection is still associated with various intraoperative complications (hemorrhage, injury to the tracheobronchial tree, recurrent laryngeal nerve injury) and postoperative complications (anastomotic leak; mediastinitis; respiratory problems, including pleural effusion, pneumonia, and acute respiratory distress syndrome; cardiac and functional complications).
  • Postoperative tumor recurrence is not uncommon in patients undergoing curative resection for esophageal cancer and can be categorized as either locoregional (locoregional lymph node metastases, anastomotic recurrence) or distant (hematogenous metastases, pleural or peritoneal seeding).
  • Hematogenous metastases most commonly involve the liver, lungs, and bones, followed by the adrenal glands, brain, and kidneys.
  • Hematogenous metastases may also involve multiple organs simultaneously.
  • The radiologist must understand how these procedures can affect imaging data and be familiar with the appearances of postoperative anatomic changes, complications, and tumor recurrence to ensure accurate evaluation of affected patients.
  • [MeSH-major] Esophageal Neoplasms / radiography. Esophageal Neoplasms / surgery. Esophagectomy / adverse effects. Hemorrhage / radiography. Neoplasm Recurrence, Local / prevention & control. Neoplasm Recurrence, Local / radiography. Radiography, Thoracic / methods

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  • [Copyright] (c) RSNA, 2007.
  • (PMID = 17374861.001).
  • [ISSN] 1527-1323
  • [Journal-full-title] Radiographics : a review publication of the Radiological Society of North America, Inc
  • [ISO-abbreviation] Radiographics
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 77
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50. Maruyama S, Ito M, Hirano Y, Shimo T, Hashida S, Iga K, Inukai M, Kanaya Y, Yokoyama N: [A case of recurrent breast cancer with multiple lung metastases responding to anastrozole monotherapy]. Gan To Kagaku Ryoho; 2008 Oct;35(10):1787-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [A case of recurrent breast cancer with multiple lung metastases responding to anastrozole monotherapy].
  • A 51-year-old postmenopausal woman was referred to our hospital for treatment of ER-positive recurrent breast cancer.
  • The patient had lung and pleural metastases with pleural effusion from breast cancer.
  • The efficacy of the treatment was definite: the multiple metastatic lung lesions showed a partial response after 5 months' treatment, and reached a complete response after 14 months' treatment.
  • Anastrozole therapy is a useful treatment for postmenopausal woman with ER-positive recurrent breast cancer.
  • [MeSH-major] Breast Neoplasms / drug therapy. Breast Neoplasms / pathology. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Neoplasm Recurrence, Local / drug therapy. Nitriles / therapeutic use. Triazoles / therapeutic use
  • [MeSH-minor] Biomarkers, Tumor / blood. Female. Humans. Middle Aged

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  • (PMID = 18931590.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Nitriles; 0 / Triazoles; 2Z07MYW1AZ / anastrozole
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51. Iwata T, Nishiyama N, Izumi N, Tsukioka T, Suehiro S: Metastatic monophasic synovial sarcoma of the pleura. Ann Thorac Cardiovasc Surg; 2007 Aug;13(4):258-61
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  • [Title] Metastatic monophasic synovial sarcoma of the pleura.
  • Pleural metastasis of synovial sarcoma that originally developed in the soft tissue is a very rare entity.
  • A soft flat red tumor approximately 2 cm in diameter was shown on the pleura of the lingula, mimicking a blood clot on the pleura.
  • The tumor was removed by partial resection of the lung.
  • The mass lay in the pleura and did not seem to invade the lung parenchyma macroscopically.
  • Intraoperative frozen sectioning evidenced metastatic synovial sarcoma.
  • Many small patchy red lesions were also found on the visceral pleura of the lung and parietal pleura of the diaphragm.
  • We diagnosed unresectable pleural metastases of synovial sarcoma and finished the operation after sampling another pulmonary pleural lesion.
  • Postoperative histopathological examination revealed a solid and bundle-like proliferation of a short spindle cell tumor with a monophasic pattern, which was diagnosed as a metastatic pleural synovial sarcoma.
  • [MeSH-major] Muscle Neoplasms / pathology. Pleural Neoplasms / secondary. Sarcoma, Synovial / secondary

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  • (PMID = 17717503.001).
  • [ISSN] 1341-1098
  • [Journal-full-title] Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
  • [ISO-abbreviation] Ann Thorac Cardiovasc Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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52. Schinstine M, Abati A, Tsokos M, Fox E, Filie AC: Cytological identification of metastatic epithelial nephroblastoma in pleural fluid: report of a case and review of literature. Diagn Cytopathol; 2006 Sep;34(9):621-5
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  • [Title] Cytological identification of metastatic epithelial nephroblastoma in pleural fluid: report of a case and review of literature.
  • Nephroblastoma (Wilms' tumor) is the most common childhood renal tumor and usually presents with a histology and cytology consisting of blastemal, epithelial, and stromal cells.
  • Effusions are not uncommon and may suggest an unfavorable prognosis when containing anaplastic tumor cells.
  • In the present case, we report the cytological appearance of a Wilms' tumor metastatic to the pleura.
  • The effusion consisted primarily of tumor cells demonstrating epithelial differentiation.
  • The tumor cells mostly presented as three-dimensional aggregates in an inflammatory background.
  • The tumor cells demonstrated strong CD56 and WT1 immunoreactivity.
  • [MeSH-major] Cytodiagnosis / methods. Kidney Neoplasms / pathology. Pleural Effusion, Malignant / pathology. Pleural Neoplasms / secondary. Wilms Tumor / secondary
  • [MeSH-minor] Antigens, CD56 / analysis. Biomarkers, Tumor / analysis. Carrier Proteins / analysis. Child. DNA-Binding Proteins / analysis. Fatal Outcome. Humans. Male. Nuclear Proteins / analysis

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  • [Copyright] (c) 2006 Wiley-Liss, Inc.
  • (PMID = 16900470.001).
  • [ISSN] 8755-1039
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, CD56; 0 / Biomarkers, Tumor; 0 / Carrier Proteins; 0 / DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / WTAP protein, human
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53. Casal RF, Eapen GA, Morice RC, Jimenez CA: Medical thoracoscopy. Curr Opin Pulm Med; 2009 Jul;15(4):313-20
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  • RECENT FINDINGS: Recent data confirm the high diagnostic yield of medical thoracoscopy - both with rigid and semirigid instruments - in detecting pleural metastases and determining the origin of pleural effusions.
  • The degree of pleural adhesions found during thoracoscopy has been proposed by some authors as a prognostic factor for survival in patients with malignant pleural effusion.
  • SUMMARY: Medical thoracoscopy is an excellent tool to establish diagnosis in patients with exudative pleural effusion of unclear origin.
  • It is highly valuable in clarifying the origin of pleural effusions in patients with lung cancer, as the presence of a malignant pleural effusion is associated with poor survival and precludes the possibility of treatment with curative intention.
  • [MeSH-minor] Humans. Pleural Effusion / diagnosis. Pleural Effusion, Malignant / diagnosis. Pleurodesis / instrumentation. Pleurodesis / methods. Pleurodesis / trends. Prognosis. Thoracic Neoplasms / diagnosis

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  • (PMID = 19387349.001).
  • [ISSN] 1531-6971
  • [Journal-full-title] Current opinion in pulmonary medicine
  • [ISO-abbreviation] Curr Opin Pulm Med
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 92
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54. Isobe M, Eikawa S, Uenaka A, Nakamura Y, Kanda T, Kohno S, Kuzushima K, Nakayama E: Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient. Cancer Immun; 2009;9:8
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  • [Title] Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient.
  • An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases.
  • After tumor dormancy for 3 years, the tumor started to progress.
  • The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.
  • [MeSH-major] Adenocarcinoma / immunology. Antigens, Neoplasm / immunology. Immunity. Lung Neoplasms / immunology. Membrane Proteins / immunology. Neoplasm Regression, Spontaneous / immunology. Pleural Neoplasms / immunology
  • [MeSH-minor] Aged. CD4-Positive T-Lymphocytes / immunology. CD4-Positive T-Lymphocytes / metabolism. CD4-Positive T-Lymphocytes / pathology. CD8-Positive T-Lymphocytes / immunology. CD8-Positive T-Lymphocytes / metabolism. CD8-Positive T-Lymphocytes / pathology. Epitopes. Forkhead Transcription Factors / biosynthesis. Humans. Immunoglobulin G / metabolism. Interleukin-2 Receptor alpha Subunit / biosynthesis. Male. Neoplasm Recurrence, Local. T-Cell Antigen Receptor Specificity. T-Lymphocytes, Regulatory / immunology. T-Lymphocytes, Regulatory / metabolism. T-Lymphocytes, Regulatory / pathology

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  • (PMID = 19791734.001).
  • [ISSN] 1424-9634
  • [Journal-full-title] Cancer immunity
  • [ISO-abbreviation] Cancer Immun.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antigens, Neoplasm; 0 / CTAG1B protein, human; 0 / Epitopes; 0 / FOXP3 protein, human; 0 / Forkhead Transcription Factors; 0 / Immunoglobulin G; 0 / Interleukin-2 Receptor alpha Subunit; 0 / Membrane Proteins
  • [Other-IDs] NLM/ PMC2935771
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