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1. Kuwabara Y, Yamada T, Yamazaki K, Du WL, Banno K, Aoki D, Sakamoto M: Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis. Cancer Sci; 2008 Oct;99(10):1933-9
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  • [Title] Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis.
  • Clinical observations of cases of ovarian metastasis suggest that there may be a unique mechanism underlying ovarian-specific metastasis.
  • This study was undertaken to establish an in vivo model of metastasis to the ovary, and to investigate the mechanism of ovarian-specific metastasis.
  • We examined the capacity for ovarian metastasis in eight different human carcinoma cell lines by implantation in female NOD/SCID mice transvenously and intraperitoneally.
  • By transvenous inoculation, only RERF-LC-AI, a poorly differentiated carcinoma cell line, frequently demonstrated ovarian metastasis.
  • By intraperitoneal inoculation, four of the eight cell lines (HGC27, MKN-45, KATO-III, and RERF-LC-AI) metastasized to the ovary.
  • We compared E-cadherin expression among ovarian metastatic cell lines and others.
  • All of these four ovarian metastatic cell lines and HSKTC, a Krukenberg tumor cell line, showed E-cadherin down-regulation and others did not.
  • E-cadherin was then forcibly expressed in RERF-LC-AI, and inhibited ovarian metastasis completely.
  • We also performed histological investigation of clinical ovarian-metastatic tumor cases.
  • About half of all ovarian-metastatic tumor cases showed loss or reduction of E-cadherin expression.
  • These data suggest that E-cadherin down-regulation may be involved in ovarian-specific metastasis.
  • [MeSH-major] Cadherins / genetics. Disease Models, Animal. Down-Regulation. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology
  • [MeSH-minor] Animals. Carcinoma / genetics. Carcinoma / metabolism. Carcinoma / pathology. Cell Line, Tumor. Female. Gene Expression Regulation, Neoplastic. Humans. Immunohistochemistry. Mice. Mice, Inbred NOD. Mice, SCID. Neoplasm Metastasis. Xenograft Model Antitumor Assays

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  • (PMID = 19016752.001).
  • [ISSN] 1349-7006
  • [Journal-full-title] Cancer science
  • [ISO-abbreviation] Cancer Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Cadherins
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2. Kim MJ, Chung HH, Kim JW, Park NH, Song YS, Kang SB: Uterine corpus involvement as well as histologic type is an independent predictor of ovarian metastasis in uterine cervical cancer. J Gynecol Oncol; 2008 Sep;19(3):181-4
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  • [Title] Uterine corpus involvement as well as histologic type is an independent predictor of ovarian metastasis in uterine cervical cancer.
  • OBJECTIVE: This study aimed to investigate the independent risk factors for ovarian metastasis in cervical cancer.
  • METHODS: Among 1,040 consecutive patients who underwent operation for cervical cancer at our institution from January 1998 to July 2007, a total of 625 patients had both ovaries removed during primary operation were retrospectively selected by medical records.
  • In order to determine clinicopathological risk factors for ovarian metastasis, we analyzed patients' demographics, FIGO stage, and other pathologic findings.
  • The Chi-square or Fisher's extract tests were used to compare any association of clinicopathologic variables with ovarian metastasis.
  • For multivariate analysis, the log regression models were used to determine independent predictors for ovarian metastasis.
  • RESULTS: Overall, ovarian metastasis was detected in fourteen (2.2%) patients: two of 473 patients with squamous cell carcinoma (0.4%) and twelve of 151 patients with non-squamous cell carcinoma (7.9%), respectively (p<0.0001).
  • Univariate analysis represents age (</=45 vs. >45 years: p=0.347), histologic types (squamous vs. non-squamous, p<0.0001), FIGO stages (IA1-IIA </=4 cm vs. IB2-IIB >4 cm, p=0.054), stromal invasion (</=1/2 vs. >1/2, p=0.788), lymph node metastasis (positive vs. negative, p=0.007), parametrium (involved vs. uninvolved, p=0.145), upper vagina (involved vs. uninvolved, p=0.003), uterine corpus (involved vs. uninvolved, p<0.0001), and margin status (involved vs. uninvolved, p=0.017).
  • By multivariate analysis, uterine corpus involvement was the only independent risk factor for ovarian metastasis (p=0.008), in addition to histologic types (p<0.0001).
  • CONCLUSION: Based on our study, uterine involvement of cervical cancer is an independent predictor for ovarian metastasis, except histologic types.
  • Ovarian preservation in cervical cancer may be safely performed only when no involvement of uterine corpus is present.

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  • [Cites] Int J Gynecol Cancer. 2007 May-Jun;17(3):623-8 [17309669.001]
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  • (PMID = 19471574.001).
  • [ISSN] 2005-0380
  • [Journal-full-title] Journal of gynecologic oncology
  • [ISO-abbreviation] J Gynecol Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2676471
  • [Keywords] NOTNLM ; Adenocarcinoma / Cervical cancer / Ovarian metastasis / Squamous cell carcinoma
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3. Oranratanaphan S, Manchana T, Sirisabya N: Clinicopathologic variables and survival comparison of patients with synchronous endometrial and ovarian cancers versus primary endometrial cancer with ovarian metastasis. Asian Pac J Cancer Prev; 2008 Jul-Sep;9(3):403-7
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  • [Title] Clinicopathologic variables and survival comparison of patients with synchronous endometrial and ovarian cancers versus primary endometrial cancer with ovarian metastasis.
  • OBJECTIVES: To determine the clinicopathologic variables and survival in the patients with synchronous endometrial and ovarian cancer (synchronous group) compared to the patients with primary endometrial cancer with ovarian metastasis (metastatic group).
  • METHODS: The medical records of 423 endometrial cancer patients who received primary surgery were reviewed.
  • Fourteen patients were diagnosed as synchronous group while 49 patients were diagnosed as metastatic group.
  • RESULTS: The median age in synchronous group was significantly younger than metastatic group (47 versus 56 years).
  • Synchronous group had significantly higher incidence of low grade tumor and lower incidence of deep myometrial invasion.
  • All patients in synchronous group presented in stage I endometrial cancer.
  • Moreover, most patients (85.7%) presented in early stage ovarian cancer and only 14.3% in advanced stage ovarian cancer.
  • Synchronous group had better disease free survival (DFS) and overall survival (OS) than metastatic group.
  • CONCLUSION: The patients in synchronous group were younger, more nulliparous and had a better prognosis than the patients in the metastatic group.
  • [MeSH-major] Endometrial Neoplasms / mortality. Endometrial Neoplasms / pathology. Neoplasms, Multiple Primary / mortality. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / mortality. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Chi-Square Distribution. Combined Modality Therapy. Disease-Free Survival. Female. Humans. Immunohistochemistry. Kaplan-Meier Estimate. Middle Aged. Neoplasm Invasiveness / pathology. Neoplasm Staging. Probability. Prognosis. Registries. Retrospective Studies. Risk Assessment. Statistics, Nonparametric. Survival Analysis. Thailand

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  • (PMID = 18990010.001).
  • [ISSN] 2476-762X
  • [Journal-full-title] Asian Pacific journal of cancer prevention : APJCP
  • [ISO-abbreviation] Asian Pac. J. Cancer Prev.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Thailand
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4. Dubois N, Willems T, Myant N: [Ovarian metastasis of breast cancer: a case report. Role of cytoreductive surgery]. J Gynecol Obstet Biol Reprod (Paris); 2009 May;38(3):242-5
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  • [Title] [Ovarian metastasis of breast cancer: a case report. Role of cytoreductive surgery].
  • [Transliterated title] Métastase ovarienne du cancer du sein: à propos d'un cas. Rôle de la chirurgie cytoréductrice.
  • The ovaries are a common metastatic site for breast cancer.
  • The diagnosis and treatment of ovarian masses from a metastatic breast cancer are difficult.
  • The complete resection of these metastatic masses seems to give a benefit in terms of global survival.
  • This benefit depends on the residual tumoral volume and on the free interval between initial breast cancer diagnosis and apparition of the metastatic ovarian masses.
  • We discuss the treatment of a patient with ovarian metastasis as first sign of a metastatic breast cancer.
  • [MeSH-major] Breast Neoplasms / pathology. Breast Neoplasms / therapy. Carcinoma, Lobular / pathology. Carcinoma, Lobular / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / blood. Cyclophosphamide / therapeutic use. Epirubicin / therapeutic use. Female. Fluorouracil / therapeutic use. Humans. Mastectomy, Segmental. Middle Aged

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  • (PMID = 19304411.001).
  • [ISSN] 0368-2315
  • [Journal-full-title] Journal de gynécologie, obstétrique et biologie de la reproduction
  • [ISO-abbreviation] J Gynecol Obstet Biol Reprod (Paris)
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 3Z8479ZZ5X / Epirubicin; 8N3DW7272P / Cyclophosphamide; U3P01618RT / Fluorouracil; FEC protocol
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5. Moparty B, Gomez G, Bhutani MS: Large solitary ovarian metastasis from colorectal cancer diagnosed by endoscopic ultrasound. World J Gastroenterol; 2008 Aug 28;14(32):5096-7
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  • [Title] Large solitary ovarian metastasis from colorectal cancer diagnosed by endoscopic ultrasound.
  • A case is presented of rectal carcinoma in which during staging by endoscopic ultrasound (EUS) a second large extrarectal mass was seen not otherwise visualized on computer tomography (CT) that was a solitary ovarian metastasis.
  • The surgeon was alerted to the EUS finding prior to the planned laparoscopic colectomy.
  • On retrospective review of the CT pelvis after surgery, the radiologist could still not diagnose the ovarian lesion separated from the primary rectal tumor due to their close proximity.
  • However, on EUS we were able to clearly see on real-time imaging that there was a distinct peri-rectal mass apart from the primary rectal tumor.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / ultrasonography. Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / ultrasonography


6. Yook JH, Oh ST, Kim BS: Clinical prognostic factors for ovarian metastasis in women with gastric cancer. Hepatogastroenterology; 2007 Apr-May;54(75):955-9
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  • [Title] Clinical prognostic factors for ovarian metastasis in women with gastric cancer.
  • BACKGROUND/AIMS: Krukenberg's tumor is considered to be a metastatic carcinoma to the ovary derived from a primary malignancy, usually from the gastrointestinal tract.
  • This retrospective study tries to evaluate the clinicopathologic characteristics of ovarian metastasis in female gastric cancer and to define the prognostic factors.
  • METHODOLOGY: Of 1,890 female patients with gastric cancers, 37 patients with metastatic ovarian carcinomas were analyzed.
  • RESULTS: Patients with ovarian metastasis were younger in age, higher in primary tumor location, and far advanced in depth of invasion and lymph node metastases.
  • Ovarian metastasis was largely related to the peritoneal seeding, which was statistically significant on survival time.
  • The young female patients with far advanced gastric cancer were vulnerable to recurrence of ovarian metastasis and were considered to undergo prophylactic oophorectomy with gastrectomy.
  • The prognosis of ovarian metastasis is dismal, because this is frequently associated with the peritoneal disseminations.
  • CONCLUSIONS: It is essential to treat the peritoneal disseminations in order to improve the survival rate of female gastric cancer patients with ovarian metastasis.
  • [MeSH-major] Krukenberg Tumor / diagnosis. Krukenberg Tumor / secondary. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 17591102.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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7. McCormick CC, Giuntoli RL 2nd, Gardner GJ, Schulick RD, Judson K, Ronnett BM, Vang R, Bristow RE: The role of cytoreductive surgery for colon cancer metastatic to the ovary. Gynecol Oncol; 2007 Jun;105(3):791-5
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  • [Title] The role of cytoreductive surgery for colon cancer metastatic to the ovary.
  • OBJECTIVE: We sought to further elucidate the survival impact of cytoreductive surgery among patients with colon cancer metastatic to the ovary.
  • METHODS: All women diagnosed with primary colon cancer metastatic to the ovary at a single institution from 1980 to 2005 were retrospectively identified.
  • RESULTS: A total of 39 patients with 40 cases of colon cancer metastatic to the ovary were identified.
  • Patients with metastatic disease confined to the ovaries (n=11) had a median overall survival (OS) time of 61 months (range 15-120) compared to 17 months (range 0.5-73) for those with more extensive metastases (n=24) (p=0.0428).
  • All major complications occurred in women with diffuse disease who underwent extensive cytoreductive surgery.
  • CONCLUSIONS: The observation that optimal cytoreduction was associated with prolonged PFS and OS in both patients with localized ovarian and widespread metastases of colon cancer suggests a role for surgical management of metastatic colon cancer in women.
  • [MeSH-major] Colonic Neoplasms / pathology. Colonic Neoplasms / surgery. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Chemotherapy, Adjuvant. Disease-Free Survival. Female. Humans. Middle Aged. Neoplasms, Multiple Primary / drug therapy. Neoplasms, Multiple Primary / pathology. Neoplasms, Multiple Primary / surgery. Neoplasms, Second Primary / drug therapy. Neoplasms, Second Primary / pathology. Neoplasms, Second Primary / surgery. Retrospective Studies. Survival Rate

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  • (PMID = 17408727.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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8. Bloch-Marcotte C, Ambrosetti D, Novellas S, Caramella T, Dahman M, Thyss A, Chevallier P: Ovarian metastasis from choroidal melanoma. Clin Imaging; 2008 Jul-Aug;32(4):318-20
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  • [Title] Ovarian metastasis from choroidal melanoma.
  • Ocular melanoma has a strong tendency to metastasize often several years after its initial diagnosis was made.
  • After three treatments, a check-up with computed tomography demonstrated the presence of a right ovarian mass.
  • An ovariectomy was performed, and the pathological examination confirmed the diagnosis of an ovarian metastasis from an ocular melanoma.
  • This is the fourth case of metastasis to the ovary from an ocular melanoma reported in the medical literature.
  • [MeSH-major] Choroid Neoplasms / pathology. Melanoma / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Female. Humans. Liver Neoplasms / radiography. Liver Neoplasms / secondary. Middle Aged

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  • (PMID = 18603189.001).
  • [ISSN] 1873-4499
  • [Journal-full-title] Clinical imaging
  • [ISO-abbreviation] Clin Imaging
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Shimada M, Kigawa J, Nishimura R, Yamaguchi S, Kuzuya K, Nakanishi T, Suzuki M, Kita T, Iwasaka T, Terakawa N: Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol; 2006 May;101(2):234-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Ovarian metastasis in carcinoma of the uterine cervix.
  • BACKGROUND: The present study was conducted to determine the frequency and clinicopathological features of ovarian metastasis in a large population of patients with stage Ib-IIb cervical cancer.
  • METHODS: The study population consisted of 3471 patients with stage Ib to IIb cervical cancer who underwent radical hysterectomy, including pelvic lymphadenectomy and bilateral salpingo-oophorectomy, at our six institutions between 1981 and 2000.
  • To our knowledge, this study is the largest review of patients with ovarian metastasis from cervical cancer.
  • RESULTS: Fifty-two patients (1.50%) had ovarian metastases: 6 in stage Ib1, 12 in stage Ib2, 5 in stage IIa, and 29 in stage IIb.
  • The mean age of patients with ovarian metastasis was 49.9 years (range: 29-73 years).
  • The incidence of ovarian metastasis in patients with cervical cancer was 0.22% for stage Ib, 0.75% for stage IIa, and 2.17% for stage IIb with squamous cell carcinoma, and 3.72%, 5.26%, and 9.85%, respectively, in adenocarcinoma.
  • Ovarian metastasis occurred more frequently among patients with adenocarcinoma than among those with squamous cell carcinoma (5.31% vs. 0.79%).
  • Outcome for patients with ovarian metastasis was very poor and not related to FIGO stage and histological type.
  • The presence of ovarian metastasis did not correlate with lymph node involvement or parametrial invasion.
  • CONCLUSION: Study results indicate that ovaries can be preserved in patients with stage Ib-IIa squamous cell carcinoma but removed in all patients with adenocarcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Squamous Cell / secondary. Ovarian Neoplasms / secondary. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Hysterectomy. Lymph Node Excision. Middle Aged. Neoplasm Staging. Ovariectomy


10. Erroi F, Scarpa M, Angriman I, Cecchetto A, Pasetto L, Mollica E, Bettiol M, Ruffolo C, Polese L, Cillo U, D'Amico DF: Ovarian metastasis from colorectal cancer: prognostic value of radical oophorectomy. J Surg Oncol; 2007 Aug 1;96(2):113-7
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  • [Title] Ovarian metastasis from colorectal cancer: prognostic value of radical oophorectomy.
  • BACKGROUND: Ovarian metastases from primary colorectal cancer occur in 3-8% of female patients.
  • The aim of this study was to assess the prognostic value of radical oophorectomy for ovarian metastasis from colorectal cancer.
  • PATIENTS AND METHODS: From our series of 859 patients operated for colorectal cancer from 1982 to 2005 ten patients with isolated ovarian metastasis were retrieved.
  • Ovarian colorectal metastasis diagnosis was confirmed by pathology revision.
  • Overall and disease-free survival after radical oophorectomy for metastases were assessed and compared with literature data.
  • RESULTS: The median follow-up from ovarian metastases resection was 36 months (range 194-14).
  • Survival analysis showed that survival rate after ovarian metastasectomy was 100% at 1 year and 80% at 5 years of follow up.
  • CONCLUSION: Our study, although limited by a relatively short follow-up and small sample size, shows that bilateral oophorectomy for ovarian metastasis from colorectal cancer has a good impact on disease-free and overall survival.
  • [MeSH-major] Colonic Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovariectomy. Rectal Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Female. Humans. Middle Aged. Prognosis. Sigmoid Neoplasms / pathology


11. Kang WD, Kim CH, Cho MK, Kim JW, Kim YH, Choi HS, Kim SM: Unilateral ovarian metastasis in a case of squamous cervical carcinoma IA1. J Obstet Gynaecol Res; 2009 Aug;35(4):824-6
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  • [Title] Unilateral ovarian metastasis in a case of squamous cervical carcinoma IA1.
  • Ovarian metastasis from early-stage squamous cervical cancer is rare.
  • We report a case of unilateral ovarian metastasis from squamous cervical cancer IA1.
  • Although ovarian metastasis from early-stage squamous cervical cancer is rare, gynecological oncologists should not overlook its possibility.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Ovarian Neoplasms / secondary. Uterine Cervical Neoplasms / pathology
  • [MeSH-minor] Female. Humans. Middle Aged. Neoplasm Staging


12. Fujiwara A, Noura S, Ohue M, Shingai T, Yamada T, Miyashiro I, Ohigashi H, Yano M, Ishikawa O, Kamiura S, Tomita Y: Significance of the resection of ovarian metastasis from colorectal cancers. J Surg Oncol; 2010 Nov 1;102(6):582-7
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  • [Title] Significance of the resection of ovarian metastasis from colorectal cancers.
  • BACKGROUND: The incidence of ovarian metastases from colorectal cancers (CRCs) has been reported to occur in 3-8% of CRC patients, and the prognosis for patients is very poor.
  • We assessed the clinicopathological characteristics of CRC patients with ovarian metastasis and the significance of the resection of ovarian metastases.
  • METHODS: We retrospectively analyzed 22 CRC patients with ovarian metastases.
  • Synchronous ovarian metastases occurred in 8 patients and metachronous ovarian metastases occurred in 14 patients.
  • The overall survival at 3 years following diagnosis of ovarian metastases is estimated to be 51.1% and 43.8% at 5 years.
  • An R0 resection of metastatic sites was achieved in 15 patients and was associated with a significant increase in survival time (P = 0.0002).
  • CONCLUSIONS: Our study shows that aggressive resection of ovarian metastases from CRCs is associated with better overall survival.
  • [MeSH-major] Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adult. Aged. Female. Follow-Up Studies. Humans. Middle Aged. Ovariectomy. Peritoneal Neoplasms / mortality. Peritoneal Neoplasms / secondary. Prognosis. Recurrence. Retrospective Studies

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  • (PMID = 20677221.001).
  • [ISSN] 1096-9098
  • [Journal-full-title] Journal of surgical oncology
  • [ISO-abbreviation] J Surg Oncol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
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13. Sasaki H, Idani F, Asami S, Komoto S, Kubota T, Kumano K, Kurose Y, Kubo S, Nojima H, Yoshioka T, Muro M, Kin H, Takakura N: [A long-term survival case of bilateral ovarian metastasis of progressive gastric cancer treated by chemotherapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2478-80
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  • [Title] [A long-term survival case of bilateral ovarian metastasis of progressive gastric cancer treated by chemotherapy].
  • We report a long-term survival case treated by chemotherapy with new anticancer drugs such as S-1, CPT-11 and docetaxel after bilateral overiectomy for bilateral ovarian metastases of progressive gastric cancer.
  • A 68-year-old female, who had undergone total gastrectomy with D2 lymphadenectomy for scirrhous gastric cancer of Stage IIIA, was admitted because of ovarian metastasis.
  • Laparoscopic bilateral ovariectomy was performed for ovarian metastases of the gastric cancer (Krukenberg tumor) 6 months after gastrectomy.
  • Seven months after gastrectomy, 11-course of S-1 treatment (80 mg/m2) for bilateral ovarian metastases of the gastric cancer was administered.
  • CT scan and PET-CT showed no new metastasis in 4 years and 10 months after gastrectomy.
  • [MeSH-major] Adenocarcinoma, Scirrhous / pathology. Krukenberg Tumor / drug therapy. Krukenberg Tumor / secondary. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology

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  • (PMID = 21224612.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Antineoplastic Agents, Phytogenic; 0 / Drug Combinations; 0 / Taxoids; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 15H5577CQD / docetaxel; 5VT6420TIG / Oxonic Acid; 7673326042 / irinotecan; XT3Z54Z28A / Camptothecin
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14. Li LY, Zeng SY, Wan L, Ao MH: [Study of the risk factors for ovarian metastasis in patients with endometrial carcinoma]. Zhonghua Fu Chan Ke Za Zhi; 2008 May;43(5):352-5
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  • [Title] [Study of the risk factors for ovarian metastasis in patients with endometrial carcinoma].
  • OBJECTIVE To investigate the risk factors for ovarian metastasis and the possibility of ovarian preservation in patients with endometrial carcinoma.
  • METHODS: The clinicopathological features of endometrial carcinoma patients who were diagnosed and treated initially with a surgical staging procedure from Jan 1997 to Dec 2006 in our hospital were retrospectively reviewed.
  • RESULTS: Of the 638 cases reviewed, 36 (5.6%, 36/638) had ovarian metastasis.
  • Univariate analysis revealed that histological type and grade, myometrial invasion, positive peritoneal fluid cytology, pelvic lymph node metastasis, invasion of parauterine, para-aortic node metastasis and invasion of uterine serosa were significantly associated with ovarian metastasis (P < 0.05); while age, lymph-vascular invasion and cervical invasion were not significantly associated with ovarian metastasis (P > 0.05).
  • Factors predictive of ovarian metastasis by multivariate analysis were ranked as follows according to risk intensity: pelvic lymph node metastasis, positive peritoneal cytology, and histological grade.
  • CONCLUSION: In young patients with grade 1 endometrioid carcinoma, with no pelvic lymph node metastasis, no para-aortic lymph node metastasis, no myometrial invasion and with negative peritoneal fluid cytology, ovarian preservation could be considered.
  • [MeSH-major] Carcinoma, Endometrioid / pathology. Endometrial Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Age Factors. Aged. Female. Humans. Hysterectomy / methods. Lymphatic Metastasis. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Ovary / pathology. Ovary / surgery. Retrospective Studies. Risk Factors

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  • (PMID = 18953868.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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15. Lee S, Lee J, Ahn H, Park J, Kim J, Park K, Lim H, Kang W, Kim B, Park Y: The role of oophorectomy for colon cancer with ovarian metastasis. J Clin Oncol; 2009 May 20;27(15_suppl):e15113
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  • [Title] The role of oophorectomy for colon cancer with ovarian metastasis.
  • : e15113 Background: A recent study demonstrated that colorectal cancer with ovarian metastases were less responsive to chemotherapy compared to extraovarian metastases.
  • Hence, the ovary may actually represent a "sanctuary" for metastatic cells from CRC.
  • The aim of the study was to investigate the impact of oophorectomy on survival of colorectal cancer patients with ovarian metastasis.
  • METHODS: Between 1996 and 2008, 83 colorectal cancer patients underwent oophorectomy.
  • For the historical control, 47 colorectal cancer patients without oophorectomy were included in the analysis.
  • The proportion of synchronous metastasis was higher in the oophorectomy than the control group (57% vs 30%, respectively; P=.003).
  • For ovary-specific survival (date of ovarian metastasis diagnosis to death), colorectal cancer patients with oophorectomy showed significantly favorable survival than the control group (20.8 vs 10.9 months, respectively; P<.001).
  • At univariate analyses, no oophorectomy (P=.038), bilaterality of ovarian metastasis (P=0.032), the presence of extraovarian metastasis (P<0.001), elevated CEA (p<0.001), poor performance status (p=0.001), no palliative chemotherapy(p=0.001), no primary disease resection(p=0.005) were identified as significantly poor prognostic factors for overall survival.
  • The no oophorectomy, no chemotherapy, extraovarian metastasis, elevated CEA, poor performance status retained statistical significance at multivariate level. (p=0.003, p=0.004, p=0.005, p=0.015, p=0.029, respectively).
  • CONCLUSIONS: Based on this retrospective analysis, the oophorectomy significantly prolonged survival in colorectal cancer patients with ovarian metastases.
  • A potential role of oophorectomy in the management of colorectal cancer should be prospectively studied.

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  • (PMID = 27960847.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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16. Aoki Y, Inamine M, Hirakawa M, Kudaka W, Nagai Y: Heparanase expression and angiogenesis in endometrial cancer: Analyses of RT-PCR and immunohistochemistry. J Clin Oncol; 2009 May 20;27(15_suppl):5535
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  • [Title] Heparanase expression and angiogenesis in endometrial cancer: Analyses of RT-PCR and immunohistochemistry.
  • : 5535 Background: The human heparanase has been shown to function in tumor progression, metastatic spread, and tumor angiogenesis.
  • The aim of the present study was to assess heparanase expression in endometrial cancer in correlation with neovascularization and clinicopathological factors.
  • Tumor angiogenesis was assessed using microvessel counting.
  • RESULTS: The expression of heparanase mRNA was detected in 26 of 52 (50%) endometrial cancers, and was significantly correlated with FIGO stage IIIc (p = 0.0075), the presence of lymph-vascular space involvement (LVSI) (p = 0.0041), lymph node metastasis (LNM) (p = 0.0049), and histological tumor grade (p = 0.003).
  • IHC showed that the heparanase was expressed in 23 of 52 (44.2%) endometrial cancers, which was significantly related to LVSI (p = 0.0028), depth of myometrial invasion (p = 0.0026), and histological tumor grade (p = 0.0135).
  • Microvessel density was also associated with FIGO stage IIIc (p = 0.027), LVSI (p = 0.001), LNM (p = 0.038), ovarian metastasis (p = 0.03) and histological tumor grade (p = 0.003).
  • CONCLUSIONS: These results suggest that the expression of heparanase can promote tumor angiogenesis and develop metastasis in endometrial cancer.

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  • (PMID = 27962489.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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17. Song H, Kim J, Do Y, Lee W, Ryu S, Kim I, Sohn S: The clinical significance of oophorectomy in gastric patients. J Clin Oncol; 2009 May 20;27(15_suppl):e15646
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  • : e15646 Background: The oophorectomy in isolated metastasis of ovary can lead to long term survival in patients with gastric cancer, but the clinical significance of oophorectomy in stage IV gastric cancer patients is not known well in this time.
  • METHODS: We reviewed the medical record of the 55 gastric cancer patients who were metastasis or recurrent in ovary at Dongsan Medical Center, Kimyung University School of Medicine, Daegu, Korea from 1985 to 2008.
  • RESULTS: Twenty-one patients were metastasis to ovary at the time of diagnosis of gastric cancer, and 34 patients were recurrent in ovary after the gastric resection.
  • The mean age was 45.3 ± 11.6 years in metastatic cancer and 46.8 ±12.6 years in recurrent cancer patients.
  • Oophorectomy were performed in 33 (97.1%) of recurrent cancer, and 17 (81.0%) of metastatic cancer.
  • The 1-year and 2-year survival rate of metastatic cancer were 14.7%, and 0%, and 1-year, 2-year, and 3-year survival rate of recurrent cancer were 47.2%, 18.1%, and 0%, respectively.
  • The median survival duration of metastatic cancer were 8.9 ±1.0 months, and recurrent cancer were 11.4 ±2.3 months.
  • Recurrent cancer were better survival than metastatic cancer patients (p=0.014).
  • The long-term survival (over 2 years) was noted in 5 patients of recurrent cancer patients.
  • The stage of gastric cancer was correlated to overall survival time in total patients (p=0.028).
  • But, the relapse-free survival time after gastrectomy is the only factor to predict survival duration after oophorectomy in recurrent cancer patients (p=0.029).
  • Age, stage of gastric cancer, extent of involvement of ovary, and systemic chemotherapy were not related to survival time of recurrent cancer patients.
  • CONCLUSIONS: The survival time in patients with oophorectomy in recurrent gastric cancer was correlated to relapse-free survival time after gastric resection.

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  • (PMID = 27962732.001).
  • [ISSN] 1527-7755
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Shan Y, Che X, Zhao DB, Bi JJ, Zhou ZX, Shao YF: [Surgical management of ovarian metastasis from colorectal cancer]. Zhonghua Wei Chang Wai Ke Za Zhi; 2007 Mar;10(2):146-8
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  • [Title] [Surgical management of ovarian metastasis from colorectal cancer].
  • OBJECTIVE: To investigate the surgical treatment of ovarian metastasis from colorectal cancer.
  • METHODS: The clinical data of 62 cases suffering from ovarian metastasis from colorectal cancer, collected from Jan.
  • RESULTS: The median survival time of 62 colorectal cancer patients with ovarian metastasis was 23 months.
  • The median survival time of 19 patients with simple ovary metastasis was 31 months, while that of 43 patients with ovary and other organ metastasis was 21 months.
  • Fifty-one patients (82.3%) were treated with double-sided ovarian resection, and 42 of them (17.7%) received hysterectomies at the same time.
  • Eleven patients received one-sided ovarian resection, and 8 of them were resected the metastatic ovaries on the other side in 3 to 10 months.
  • CONCLUSIONS: The patients with ovarian metastases from colorectal cancer need double-sided ovarian resection, and radical resection is able to prolong the survival time.
  • [MeSH-major] Colorectal Neoplasms / pathology. Colorectal Neoplasms / surgery. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery


19. Milingos D, Doumplis D, Savage P, Seckl M, Lindsay I, Smith JR: Placental site trophoblastic tumor with an ovarian metastasis. Int J Gynecol Cancer; 2007 Jul-Aug;17(4):925-7
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  • [Title] Placental site trophoblastic tumor with an ovarian metastasis.
  • Placental site trophoblastic tumors (PSTT) are the rarest form of gestational trophoblastic disease (GTD).
  • The most common metastatic sites are the lung, liver, and vagina while spread to the adnexa is relatively unusual.
  • We describe a case of a 35-year-old woman presenting with PSTT and ovarian metastasis who was successfully treated with radical hysterectomy, bilateral oophorectomy, pelvic lymph node dissection, and postoperative chemotherapy.
  • The case highlights the possibility of ovarian metastases despite normal preoperative imaging and confirms the value of multidisciplinary management of this rare illness.
  • [MeSH-major] Ovarian Neoplasms / secondary. Trophoblastic Tumor, Placental Site / pathology. Uterine Neoplasms / pathology
  • [MeSH-minor] Adult. Combined Modality Therapy. Female. Humans. Neoplasm Metastasis. Pregnancy

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  • (PMID = 17343608.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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20. Sakakura C, Hagiwara A, Yoshikawa T, Hamada T, Yamagishi H: Huge ovarian metastasis from jejunal cancer occurring immediately after initial operation. Hepatogastroenterology; 2005 Mar-Apr;52(62):425-8
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  • [Title] Huge ovarian metastasis from jejunal cancer occurring immediately after initial operation.
  • Correct preoperative diagnosis of jejunal cancer is difficult, and there are no clear guidelines for the postoperative follow-up to monitor the recurrence of jejunal cancer.
  • This report describes asynchronous ovarian metastasis from jejunal cancer occurring after initial operation.
  • The patient was a 68-year-old postmenopausal woman with a preoperatively correctly diagnosed jejunal cancer.
  • Three months later, vaginal bleeding and a large metastasis in the left ovary were detected, for which a left oophorectomy was performed.
  • Our case demonstrates that it is necessary to pay careful attention to synchronous or non-synchronous metastases to the ovaries after operation for jejunal cancer in females.
  • Consideration should also be given to the efficacy of oophorectomy for ovarian metastases and of intensive chemotherapy combined with jejunal resection for carcinoma because of the poor prognosis of these treatment modalities.
  • [MeSH-major] Carcinoma / pathology. Carcinoma / surgery. Jejunal Neoplasms / pathology. Jejunal Neoplasms / surgery. Ovarian Neoplasms / secondary
  • [MeSH-minor] Angiography. Chemotherapy, Adjuvant. Female. Humans. Magnetic Resonance Imaging. Middle Aged. Neoplasm Invasiveness. Ovariectomy. Peritoneum / pathology. Postoperative Period. Radiography, Abdominal. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 15816449.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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21. Che X, Shan Y, Zhou ZX, Zhao DB, Bi JJ, Shao YF, Zhao P: [Surgial treatment and prognosis of ovarian metastasis from colorectal cancer]. Zhonghua Zhong Liu Za Zhi; 2007 Nov;29(11):864-6
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  • [Title] [Surgial treatment and prognosis of ovarian metastasis from colorectal cancer].
  • OBJECTIVE: To summarize the surgical treatment experiece and to investigate the prognosis of the patients with ovarian metastasis from colorectal cancer.
  • METHODS: The data of 67 patients with synchronous or asynchronous ovarian metastasis from colorectal cancer surgically treated between January 1989 and December 2005 were collected and analyzed retrospectively using Statistical Package for the Social Sciences (Release 11.5, SPSS, Inc).
  • Univariate analysis revealed that the metastasis was confined in the ovary or pelvis only, unilateral/double ovarian metastasis, and operation mode were all statistically significant prognostic factors (P <0.05).
  • CONCLUSION: Surgical treatment is still the most effective mode in the treatment for the ovary metastasis from colorectal cancer.
  • [MeSH-major] Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovariectomy / methods
  • [MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Carcinoma, Signet Ring Cell / secondary. Carcinoma, Signet Ring Cell / surgery. Female. Follow-Up Studies. Humans. Hysteroscopy / methods. Middle Aged. Proportional Hazards Models. Retrospective Studies. Survival Rate


22. Castadot P, Magné N, Berghmans T, Drowart A, Baeyens L, Smets D, Van Houtte P: [Ovarian metastasis and lung adenocarcinoma: a case report]. Cancer Radiother; 2005 May;9(3):183-6
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  • [Title] [Ovarian metastasis and lung adenocarcinoma: a case report].
  • Ovarian metastasis as first dissemination site of a lung adenocarcinoma has not been described in the literature.
  • We report the case of a 61-year-old woman who had a pneumectomy for a centrally located lung adenocarcinoma, which was discovered on a routine chest X-Ray.
  • Abdominal CT-scan confirmed the presence of a mass which was compatible with a primary ovarian tumor.
  • Pathology reported an adenocarcinoma.
  • Clinical course, pathological and immunohistochemical data concluded to the diagnosis of ovarian metastasis of the lung adenocarcinoma.
  • In conclusion, in the differential diagnosis of an ovarian metastasis, clinicians should not forget the lung as primary site since epidemiologic data of lung cancer in women show progressive incidence.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Immunohistochemistry. Middle Aged. Pneumonectomy. Positron-Emission Tomography

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  • (PMID = 16023045.001).
  • [ISSN] 1278-3218
  • [Journal-full-title] Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
  • [ISO-abbreviation] Cancer Radiother
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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23. Ishii M, Ishibashi K, Ishiguro T, Kuwabara K, Ohsawa T, Okada N, Miyazaki T, Yokoyama M, Inokuma S, Ishida H: [Analysis of ovarian metastasis of colorectal cancer--a comparison between ovarian metastasis and peritoneal metastasis without involving ovaries]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2257-9
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  • [Title] [Analysis of ovarian metastasis of colorectal cancer--a comparison between ovarian metastasis and peritoneal metastasis without involving ovaries].
  • This retrospective study was performed to clarify whether or not ovarian metastasis from colorectal cancer should be classified into peritoneal metastasis.
  • We compared patient background data and prognosis between patients with ovarian metastasis (ovarian group, n=16) and female patients with peritoneal metastasis without involving ovaries (peritoneal group, n=22) treated between 1998 and 2008.
  • The median overall survival period was 13.8 months for the ovarian group and 16.7 months for the peritoneal group (p=0.96).
  • The 3-year overall survival rate was 48.6%, 46.9%, and 11.5% for patients with ovarian metastasis only (P2), those with minute peritoneal metastasis without involving ovaries (P1), and those with multiple (numerous) peritoneal metastasis without involving ovaries (P3) (p=0.13), respectively.
  • These results suggest that it is valid to classify ovarian metastasis as peritoneal metastasis.
  • However, further collection of data may be needed to conclude that solitary ovarian lesion(s) would be classified into P2.
  • [MeSH-major] Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Peritoneal Neoplasms / secondary


24. Jalón Monzón A, Alvarez Múgica M, Bulnes Vázquez V, González Alvarez RC, García Rodríguez J, Martín Benito JL, Ferrer Barriendo J, Regadera Sejas FJ: [Ovarian metastasis of a primary renal cell carcinoma]. Arch Esp Urol; 2008 May;61(4):534-7
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  • [Title] [Ovarian metastasis of a primary renal cell carcinoma].
  • [Transliterated title] Metástasis ovárica de carcinoma de células renales primario.
  • OBJECTIVE: We report one case of ovarian metastasis secondary to a renal clear cell carcinoma.
  • METHODS/RESULTS: 52 year-old consulting for metrorrhagia with the initial diagnosis of primary ovarian carcinoma.
  • Tumor dissemination work up tests reported a renal mass suggestive of ovarian metastasis.
  • Final diagnosis was renal clear cell carcinoma with ovarian metastasis.
  • CONCLUSIONS: Metastases to the ovary pose a diagnostic problem in their interpretation, especially when they show a similar histology to the primary ovarian tumor.
  • Due to therapeutic and prognostic implications, it is very important to differentiate if it is a primary ovarian tumor or a metastasis from a renal carcinoma.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Ovarian Neoplasms / secondary

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  • (PMID = 18592775.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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25. Lee SJ, Lee J, Lim HY, Kang WK, Choi CH, Lee JW, Kim TJ, Kim BG, Bae DS, Cho YB, Kim HC, Yun SH, Lee WY, Chun HK, Park YS: Survival benefit from ovarian metastatectomy in colorectal cancer patients with ovarian metastasis: a retrospective analysis. Cancer Chemother Pharmacol; 2010 Jul;66(2):229-35
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  • [Title] Survival benefit from ovarian metastatectomy in colorectal cancer patients with ovarian metastasis: a retrospective analysis.
  • PURPOSE: A recent study demonstrated that colorectal cancer (CRC) with ovarian metastases was less responsive to chemotherapy compared with extraovarian metastases.
  • Hence, the ovary may actually represent a "sanctuary" for metastatic cells from CRC.
  • The aim of the study was to investigate the impact of ovarian metastatectomy on survival of CRC patients with ovarian metastasis.
  • For the historical control, 47 CRC patients with ovarian metastasis without resection were included in the analysis.
  • The proportion of synchronous metastasis was higher in the oophorectomy group than in the control group (57 vs. 30%; P = 0.003).
  • For ovary-specific survival (date of ovarian metastasis diagnosis to death), CRC patients with an oophorectomy showed a significantly more favorable survival rate than the control group (20.8 vs. 10.9 months; P < 0.001).
  • In univariate analyses, oophorectomy (P = 0.038), unilaterality of ovarian metastasis (P = 0.032), metastasis confined to ovaries (P < 0.001), normal CEA level (P < 0.001), good performance status (P = 0.001), palliative chemotherapy (P = 0.001), and primary disease resection (P = 0.005) were identified as significantly good prognostic factors for overall survival.
  • The oophorectomy, chemotherapy, metastasis confined to ovaries, normal CEA level, and good performance status retained statistical significance at the multivariate level (P = 0.003, P = 0.004, P = 0.005, P = 0.015, and P = 0.029, respectively).
  • CONCLUSIONS: Based on this retrospective analysis, the ovarian metastatectomy significantly prolonged survival in CRC patients with ovarian metastases.
  • The potential role of an ovarian metastatectomy in the management of CRC should be prospectively studied.
  • [MeSH-major] Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovary / surgery
  • [MeSH-minor] Adult. Aged. Disease-Free Survival. Factor Analysis, Statistical. Female. Humans. Kaplan-Meier Estimate. Middle Aged. Ovariectomy. Prognosis. Retrospective Studies. Survival Analysis. Treatment Outcome


26. Choi HJ, Lee JH, Kang S, Seo SS, Choi JI, Lee S, Park SY: Contrast-enhanced CT for differentiation of ovarian metastasis from gastrointestinal tract cancer: stomach cancer versus colon cancer. AJR Am J Roentgenol; 2006 Sep;187(3):741-5
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  • [Title] Contrast-enhanced CT for differentiation of ovarian metastasis from gastrointestinal tract cancer: stomach cancer versus colon cancer.
  • OBJECTIVE: The purpose of our study was to determine whether the CT findings of ovarian metastasis from stomach cancer differ from those of ovarian metastasis from colon cancer.
  • CONCLUSION: On contrast-enhanced CT scans, ovarian metastatic lesions from stomach cancer appear more solid than, more frequently have dense enhancement of the solid portion, and are smaller than ovarian metastatic lesions from colon cancer.
  • [MeSH-major] Colonic Neoplasms / pathology. Ovarian Neoplasms / radiography. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Contrast Media / administration & dosage. Diagnosis, Differential. Female. Humans. Iohexol / analogs & derivatives. Male. Middle Aged. Retrospective Studies. Tomography, X-Ray Computed

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  • (PMID = 16928939.001).
  • [ISSN] 1546-3141
  • [Journal-full-title] AJR. American journal of roentgenology
  • [ISO-abbreviation] AJR Am J Roentgenol
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Contrast Media; 4419T9MX03 / Iohexol; 712BAC33MZ / iopromide
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27. Madersbacher S, Ponholzer A, Franz K, Höltl W: [Synchronous bilateral renal cell cancer with a single ovarian metastasis and a fibromuscular dysplasia of the renal artery]. Aktuelle Urol; 2007 Jan;38(1):52-4
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  • [Title] [Synchronous bilateral renal cell cancer with a single ovarian metastasis and a fibromuscular dysplasia of the renal artery].
  • INTRODUCTION: Ovarian metastases of renal cell cancer (RCC) are extremely rare with less than 20 cases reported to date.
  • These metastases occur in the majority of cases metachronous (i. e. prior to or after identification of the primary tumour) or--such as in our case--synchronous.
  • CASE REPORT: A 42-year-old women was diagnosed for synchronous bilateral renal and a left-sided ovarian mass.
  • In a first surgical step, the ovarian metastasis was removed laparoscopically and the 20 cm tumour on the right kidney via a transperitoneal tumour nephrectomy (histology: clear cell RCC, pT3bN0V1R0M1).
  • CONCLUSION: Although extremely rare, the possibility of an ovarian metastasis should be considered in women with RCC.
  • The presented case was unique because of synchronous bilateral RCC, an ovarian metastasis and a fibromuscular dysplasia of the renal artery requiring a sophisticated surgical approach.
  • [MeSH-major] Carcinoma, Renal Cell / secondary. Fibromuscular Dysplasia / diagnosis. Kidney Neoplasms / diagnosis. Neoplasms, Multiple Primary / secondary. Ovarian Neoplasms / secondary. Renal Artery Obstruction / diagnosis
  • [MeSH-minor] Adult. Anastomosis, Surgical. Blood Vessel Prosthesis Implantation. Female. Humans. Laparoscopy. Neoplasm Staging. Nephrectomy. Postoperative Complications / diagnosis. Postoperative Complications / therapy. Stents


28. Yamaguchi T, Takahashi H, Kagawa R, Takeda R, Sakata S, Yamamoto M, Nishizaki D, Iwasa Y: The role of prophylactic bilateral oophorectomy at the time of initial diagnosis of a unilateral ovarian metastasis in cases with colorectal adenocarcinoma. Hepatogastroenterology; 2008 Mar-Apr;55(82-83):434-7
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  • [Title] The role of prophylactic bilateral oophorectomy at the time of initial diagnosis of a unilateral ovarian metastasis in cases with colorectal adenocarcinoma.
  • BACKGROUND/AIMS: In cases with a macroscopic unilateral ovarian metastasis of colorectal adenocarcinoma, a clear therapeutic policy regarding a prophylactic bilateral oophorectomy is lacking.
  • METHODOLOGY: Four cases of ovarian metastases of colorectal adenocarcinoma are presented.
  • RESULTS: Case 1 is a 63-year-old with ascending colon carcinoma, Dukes' C, and right oophorectomy due to metachronous ovarian metastasis.
  • Case 2 is a 28-year-old with transverse colon carcinoma, Dukes' D, and right oophorectomy due to synchronous ovarian metastasis.
  • Case 3 is a 40-year-old with rectal carcinoma, Dukes' B, and right oophorectomy due to metachronous ovarian metastasis.
  • Case 4 is a 32-year-old with rectal carcinoma, Dukes' D, and bilateral oophorectomy due to synchronous and metachronous ovarian metastases.
  • Later, in cases 1 and 3, in which a unilateral ovary was preserved, ovarian metastases to the preserved ovary were found and caused severe clinical symptoms.
  • CONCLUSIONS: Without other extensive metastases, if demonstrable diseases are found in a unilateral ovary, a prophylactic bilateral oophorectomy is recommended.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Colorectal Neoplasms / pathology. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovariectomy / methods

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  • (PMID = 18613382.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
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29. Imamura H, Kishimoto T, Kawabata R, Furukawa H, Fukunaga M, Ohzato H, Miyanishi K, Yamamoto T, Miwa H: [A case of gastric cancer with bilateral ovarian metastasis after gastrectomy performed ovarian resection]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2490-2
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  • [Title] [A case of gastric cancer with bilateral ovarian metastasis after gastrectomy performed ovarian resection].
  • The patient was a 51-year-old female, who underwent radical surgery for cancer of remnant stomach in May 2006 (f-T4N0M0P0H0CY0, por 2, Stage IIIA, Cur B).
  • Bilateral ovarian resection was performed in March 2009 for bilateral ovarian metastasis, so called "Krukenberg tumor" with peritoneal dissemination detected with CT scan after one-year adjuvant chemotherapy with S-1 (80 mg/m2, 4 weeks on and 2 weeks off).
  • In ovary metastasis of gastric cancer, even if accompanied by peritoneum metastasis, ovarian resection as a reduction surgery followed by chemotherapy may improve survival.
  • [MeSH-major] Krukenberg Tumor / secondary. Krukenberg Tumor / therapy. Ovarian Neoplasms / secondary. Ovarian Neoplasms / therapy. Stomach Neoplasms / pathology. Stomach Neoplasms / surgery

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  • (PMID = 21224616.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Antineoplastic Agents; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; Q20Q21Q62J / Cisplatin
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30. Taranto AJ, Lourie R, Lau WF: Ovarian vascular pedicle sign in ovarian metastasis arising from gall bladder carcinoma. Australas Radiol; 2006 Oct;50(5):504-6
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  • [Title] Ovarian vascular pedicle sign in ovarian metastasis arising from gall bladder carcinoma.
  • A case of a large mass in the pelvis confirmed to be a rare ovarian metastasis arising from a primary adenocarcinoma of the gall bladder is presented.
  • The value of the recently described ovarian pedicle sign in confirming the organ of origin of the pelvic mass is emphasized.
  • [MeSH-major] Adenocarcinoma / pathology. Gallbladder Neoplasms / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary. Ovary / radiography. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Contrast Media / administration & dosage. Diagnosis, Differential. Female. Fluorodeoxyglucose F18. Humans. Middle Aged. Positron-Emission Tomography / methods. Radiographic Image Enhancement / methods. Rare Diseases

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  • (PMID = 16981953.001).
  • [ISSN] 0004-8461
  • [Journal-full-title] Australasian radiology
  • [ISO-abbreviation] Australas Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Contrast Media; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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31. Huang SY, Jung SM, Ng KK, Chang YC, Lai CH: Ovarian metastasis in a nulliparous woman with endometrial adenocarcinoma failing conservative hormonal treatment. Gynecol Oncol; 2005 May;97(2):652-5
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  • [Title] Ovarian metastasis in a nulliparous woman with endometrial adenocarcinoma failing conservative hormonal treatment.
  • BACKGROUND: There have been several reports about successful fertility-preserving treatment of endometrial carcinoma with subsequent pregnancy.
  • However, conservative hormonal treatment for early-stage endometrial cancer still entails some risk.
  • CASE: We present a 36-year-old nulliparous woman, initially diagnosed as clinical stage IA, grade 1 endometrial adenocarcinoma, receiving 6-month conservative treatment with remission achieved at 4 months from diagnosis.
  • The final pathology revealed well-differentiated endometrioid adenocarcinoma with inner one-third myometrial invasion and right ovarian metastasis.
  • CONCLUSION: This case report signals a warning that negative preoperative imaging studies are not reassuring for a relapsing low-grade, early-stage endometrial carcinoma failing conservative treatment.
  • [MeSH-major] Adenocarcinoma / drug therapy. Adenocarcinoma / secondary. Endometrial Neoplasms / drug therapy. Endometrial Neoplasms / pathology. Megestrol Acetate / therapeutic use. Ovarian Neoplasms / secondary

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  • (PMID = 15863173.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] TJ2M0FR8ES / Megestrol Acetate
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32. Lu Y, Goldblatt JC: Multiple mediastinal metastasis of ovarian carcinoma. Heart Lung Circ; 2005 Jun;14(2):118-20
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  • [Title] Multiple mediastinal metastasis of ovarian carcinoma.
  • Secondary mediastinal tumours are rare.
  • We present a case report of multiple mediastinal metastasis of ovarian cancer, a very rare occurrence with only two cases previously reported in the literature.
  • [MeSH-major] Carcinoma, Papillary / secondary. Mediastinal Neoplasms / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 16352267.001).
  • [ISSN] 1443-9506
  • [Journal-full-title] Heart, lung & circulation
  • [ISO-abbreviation] Heart Lung Circ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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33. Alloni R, Garberini A, Caputo D, Coppola R: Solitary splenic metastasis of ovarian carcinoma: report of two cases. Surg Today; 2008;38(12):1144-7
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  • [Title] Solitary splenic metastasis of ovarian carcinoma: report of two cases.
  • Capsular splenic metastasis from ovarian cancer, which is associated with peritoneal spread, is not uncommon.
  • Conversely, solitary involvement of the splenic parenchymal is unusual, and secondary debulking may improve the prognosis if there is no sign of residual disease.
  • Thus, splenectomy is indicated for this type of isolated splenic metastasis.
  • We report two cases of successful splenectomy for solitary splenic metastasis of ovarian carcinoma and review the relevant literature.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Ovarian Neoplasms / pathology. Splenectomy. Splenic Neoplasms / secondary. Splenic Neoplasms / surgery
  • [MeSH-minor] Breast Neoplasms / surgery. Carcinoma, Ductal, Breast / surgery. Chemotherapy, Adjuvant. Female. Humans. Laparoscopy. Magnetic Resonance Imaging. Middle Aged. Neoplasms, Second Primary / surgery. Positron-Emission Tomography. Tomography, X-Ray Computed

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  • (PMID = 19039644.001).
  • [ISSN] 0941-1291
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Japan
  • [Number-of-references] 23
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34. Abbas O, Salem Z, Haddad F, Kibbi AG: Perforating cutaneous metastasis from an ovarian adenocarcinoma. J Cutan Pathol; 2010 Sep;37(9):e53-6
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  • [Title] Perforating cutaneous metastasis from an ovarian adenocarcinoma.
  • Cutaneous metastasis from ovarian cancer usually presents clinically as firm papules and nodules on the trunk.
  • Histology commonly exhibits a dermal infiltrate of malignant cells.
  • In this report, we describe a peculiar presentation of perforating cutaneous metastasis from an ovarian carcinoma, which to the best of our knowledge has not been reported previously.
  • [MeSH-major] Adenocarcinoma / secondary. Ovarian Neoplasms / pathology. Rupture, Spontaneous. Skin Neoplasms / secondary
  • [MeSH-minor] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biomarkers, Tumor / metabolism. Chemotherapy, Adjuvant. Cisplatin / therapeutic use. Female. Humans. Neoplasm Metastasis. Paclitaxel / therapeutic use

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  • (PMID = 19615029.001).
  • [ISSN] 1600-0560
  • [Journal-full-title] Journal of cutaneous pathology
  • [ISO-abbreviation] J. Cutan. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin
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35. Guney S, Guney N, Ozcan D, Sayilgan T, Ozakin E: Ovarian metastasis of a primary renal cell carcinoma: case report and review of literature. Eur J Gynaecol Oncol; 2010;31(3):339-41
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  • [Title] Ovarian metastasis of a primary renal cell carcinoma: case report and review of literature.
  • Ovarian metastases from renal cell carcinoma (RCC) are very rare, with only 23 cases reported in the literature.
  • We report a case of 54-year-old women who developed bilateral ovarian metastasis 39 months after diagnosis of clear cell carcinoma.
  • Subsequently she was treated with sunitinib and her disease stabilized.
  • She is still alive four years after diagnosis of the renal primary, and disease has stabilized on sunitinib.
  • We conclude that, although rare, the possibility of metastatic RCC should be considered in the differential diagnosis of clear cell tumors of the ovary.
  • Due to therapeutic and prognostic implications, it is very important to differentiate if the tumor is a primary ovarian tumor or a metastasis from a renal cell carcinoma.
  • Early diagnosis of this rare metastatic tumor results in prompt treatment and prolonged patient survival.
  • [MeSH-major] Carcinoma, Renal Cell / pathology. Kidney Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 21077484.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Italy
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36. Jeremić K, Berisavac M, Argirović R, Gojnić M, Bosković V, Milenković V, Mostić T: Solitary ovarian metastasis from cutaneous melanoma--case report. Eur J Gynaecol Oncol; 2006;27(4):443-4
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  • [Title] Solitary ovarian metastasis from cutaneous melanoma--case report.
  • A 47-year-old patient with two previous deliveries and three deliberate abortions was admitted to the Institute of Gynecology and Obstetrics, Clinical Center of Serbia with the diagnosis of a uterine myoma and left adnexal mass.
  • Five years previously, she had undergone excision of a malignant melanoma from her left leg.
  • The final histopathological diagnosis was metastatic amelanotic malignant melanoma of the left ovary and uterine myomas.
  • [MeSH-major] Melanoma / secondary. Ovarian Neoplasms / secondary. Skin Neoplasms / pathology

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  • (PMID = 17009650.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / CA-125 Antigen
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37. Singh S, Gupta P, Khanna R, Khanna AK: Simultaneous breast and ovarian metastasis from gallbladder carcinoma. Hepatobiliary Pancreat Dis Int; 2010 Oct;9(5):553-4
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  • [Title] Simultaneous breast and ovarian metastasis from gallbladder carcinoma.
  • BACKGROUND: Gallbladder carcinoma is a common malignancy in the Indian subcontinent.
  • A common extra-abdominal site of metastasis is the lungs.
  • Simultaneous metastasis to breast and ovary is extremely rare.
  • METHOD: This report describes an unusual case of carcinoma gallbladder metastasizing to the breast and ovary at the same time.
  • Ultrasound of the abdomen revealed hepatomegaly with thick-walled gallbladder with multiple stones and a mass at the fundus, but normal uterus and ovary.
  • Histopathological examination revealed a poorly-differentiated adenocarcinoma with mar-gins free from tumor infiltration.
  • Ultrasound of the abdomen for metastatic workup revealed an ovary mass.
  • Simple mastectomy and salphingo-opherectomy were performed, and histopathological examination revealed a metastatic adenocarcinoma.
  • CONCLUSION: This is an unusual case of carcinoma of the gallbladder with metastasis to the breast and ovary, which has not been documented before.
  • [MeSH-major] Adenocarcinoma / secondary. Breast Neoplasms / secondary. Gallbladder Neoplasms / pathology. Ovarian Neoplasms / secondary

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  • (PMID = 20943468.001).
  • [ISSN] 1499-3872
  • [Journal-full-title] Hepatobiliary & pancreatic diseases international : HBPD INT
  • [ISO-abbreviation] HBPD INT
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine
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38. Nishimura T, Maeda Y, Okada T, Nakamura M, Sakata K, Setoguchi M, Kawasaki N: [Ovarian metastasis after complete response of colon cancer]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2263-5
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  • [Title] [Ovarian metastasis after complete response of colon cancer].
  • We report a case of ovarian metastasis after complete response of colon cancer.
  • A 55-year-old woman underwent a sigmoidectomy for sigmoid colon cancer with hepatic metastasis and para-aorta lymph node metastasis.
  • Thirteen months after the operation, right ovarian tumor was found and bilateral oophrectomy, hysterectomy and omentectomy were performed.
  • Histopathologically the ovarian tumor was metastasized from colonic cancer.
  • At present, the patient remains disease-free for 6 months after the ovarian operation.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Colonic Neoplasms / drug therapy. Ovarian Neoplasms / secondary

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  • (PMID = 20037390.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Angiogenesis Inhibitors; 0 / Antibodies, Monoclonal; 0 / Antibodies, Monoclonal, Humanized; 0 / Organoplatinum Compounds; 2S9ZZM9Q9V / Bevacizumab; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil; XT3Z54Z28A / Camptothecin; Folfox protocol; IFL protocol
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39. Yilmaz Z, Bese T, Demirkiran F, Ilvan S, Sanioglu C, Arvas M, Kosebay D: Skin metastasis in ovarian carcinoma. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:414-8
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  • [Title] Skin metastasis in ovarian carcinoma.
  • We report a case of 69-year-old woman who presented with pleural metastasis of a serous papillary adenocarcinoma of the ovary.
  • After chemotherapy and surgery, she had 2 years disease-free survival.
  • The skin biopsy revealed metastasis of adenocarcinoma in the dermis.
  • She died after 4 months of the diagnosis of the skin metastasis.
  • In 20 years experience in our unit, it is the first time that we recognize a cutaneous metastasis in ovarian cancer.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Ovarian Neoplasms / pathology. Pleural Neoplasms / secondary. Skin Neoplasms / secondary
  • [MeSH-minor] Aged. Carboplatin / administration & dosage. Disease-Free Survival. Fatal Outcome. Female. Gynecologic Surgical Procedures. Humans. Paclitaxel / administration & dosage

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  • (PMID = 16515636.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] BG3F62OND5 / Carboplatin; P88XT4IS4D / Paclitaxel
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40. De Gregorio N, Schmitt W, Kreienberg R, Wulff C: Ovarian metastasis of a lymphoma presenting as primary ovarian cancer. Onkologie; 2009 Dec;32(12):752-3
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  • [Title] Ovarian metastasis of a lymphoma presenting as primary ovarian cancer.
  • BACKGROUND: Ovarian metastases are being found in a variety of different malignant diseases.
  • CASE REPORT: A clinical case of a woman with a pelvic tumor and elevated CA125 levels, and suspected primary ovarian carcinoma is presented.
  • Surgery revealed a metastasis of a B-cell non-Hodgkin's lymphoma.
  • [MeSH-major] Lymphoma / diagnosis. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged

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  • [Copyright] Copyright 2009 S. Karger AG, Basel.
  • [CommentIn] Onkologie. 2010;33(8-9):480 [20838066.001]
  • (PMID = 20016237.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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41. Otrock ZK, Seoud MA, Khalifeh MJ, Makarem JA, Shamseddine AI: Laparoscopic splenectomy for isolated parenchymal splenic metastasis of ovarian cancer. Int J Gynecol Cancer; 2006 Sep-Oct;16(5):1933-5
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  • [Title] Laparoscopic splenectomy for isolated parenchymal splenic metastasis of ovarian cancer.
  • Metastatic carcinoma of the spleen occurs in a setting of widespread malignant disease.
  • Solitary parenchymal splenic metastasis of ovarian carcinoma is rare.
  • We report a case of a 59-year-old woman who presented with an elevated serum CA125 level due to a solitary splenic metastasis after a long disease-free period.
  • The literature contains 16 cases of solitary parenchymal splenic metastasis of ovarian carcinoma.
  • [MeSH-major] Cystadenocarcinoma, Serous / secondary. Ovarian Neoplasms / pathology. Splenic Neoplasms / secondary

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  • (PMID = 17009994.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / CA-125 Antigen
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42. Duncan C, Powers J, Davis T, Spraker T: Abomasal and uterine adenocarcinomas with ovarian metastasis in a captive elk (Cervus elaphus nelsoni). J Vet Diagn Invest; 2007 Sep;19(5):560-3
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  • [Title] Abomasal and uterine adenocarcinomas with ovarian metastasis in a captive elk (Cervus elaphus nelsoni).
  • Histologically the tumor was an adenocarcinoma.
  • Histologic examination of the ovaries revealed unilateral metastasis.
  • A focal, 1-cm diameter adenocarcinoma was identified within the abomasum; this tumor was histologically distinct from the neoplasm found in the uterus and ovary.
  • Although this elk had a history of experimental reproductive treatments, including leuprolide, gonadotropin-releasing hormone vaccine, and Brucella abortus vaccination, it was most likely that both tumors represent spontaneous, independent neoplastic transformations and were unrelated.
  • [MeSH-major] Adenocarcinoma / veterinary. Deer. Ovarian Neoplasms / veterinary. Uterine Neoplasms / veterinary
  • [MeSH-minor] Abomasum / pathology. Animals. Female. Ovary / pathology. Uterus / pathology

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  • (PMID = 17823404.001).
  • [ISSN] 1040-6387
  • [Journal-full-title] Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • [ISO-abbreviation] J. Vet. Diagn. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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43. Jung HJ, Lee HY, Kim BW, Jung SM, Kim HG, Ji JS, Choi H, Lee BI: Gastric Metastasis from Ovarian Adenocarcinoma Presenting as a Submucosal Tumor without Ulceration. Gut Liver; 2009 Sep;3(3):211-4
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  • [Title] Gastric Metastasis from Ovarian Adenocarcinoma Presenting as a Submucosal Tumor without Ulceration.
  • Metastatic gastric cancer is extremely rare and gastric metastasis from ovarian adenocarcinoma has rarely been reported.
  • All of the previously reported metastatic lesions presented as an ulcerative lesions.
  • We report a case of 49-year-old woman in which gastric metastasis from ovarian adenocarcinoma presented as a submucosal tumor without ulceration on endoscopic examination.
  • Gastrointestinal stromal tumor was suspected on endoscopic ultrasound (EUS) examination.
  • It was confirmed histopathologically as metastatic ovarian adenocarcinoma after endoscopic submucosal dissection (ESD) with enucleation.
  • Submucosal tumor of the stomach in patients with ovarian carcinoma should not be overlooked and ESD with enucleation may be a viable option when EUS with fine needle aspiration is not available.

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  • (PMID = 20431748.001).
  • [ISSN] 2005-1212
  • [Journal-full-title] Gut and liver
  • [ISO-abbreviation] Gut Liver
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Korea (South)
  • [Other-IDs] NLM/ PMC2852710
  • [Keywords] NOTNLM ; Gastric metastasis / Ovarian adenocarcinoma / Submucosal tumor
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44. Yu LB, Wang J, Ma BZ, Sun WZ: [Inhibitive effect of ursolic acid on the invasion and metastasis of ovarian carcinoma cells HO-8910PM]. Sichuan Da Xue Xue Bao Yi Xue Ban; 2010 Nov;41(6):986-8, 1038
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  • [Title] [Inhibitive effect of ursolic acid on the invasion and metastasis of ovarian carcinoma cells HO-8910PM].
  • OBJECTIVE: To study the effects of ursolic acid (UA) on the invasion and metastasis of ovarian carcinoma cell HO-8910PM and its underlying mechanism.
  • METHODS: MTT assay was performed to examine the effects of UA on the proliferation of ovarian carcinoma cells HO-8910PM in vitro.
  • UA inhibits the invasion and metastasis of HO-8910PM cells, probably through inhibiting the activity of gelatinase and the expressions of MMP-2 and MMP-9.
  • [MeSH-major] Antineoplastic Agents / pharmacology. Ovarian Neoplasms / pathology. Triterpenes / pharmacology
  • [MeSH-minor] Cell Line, Tumor. Female. Humans. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Neoplasm Invasiveness / prevention & control. Neoplasm Metastasis / prevention & control

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  • (PMID = 21265099.001).
  • [ISSN] 1672-173X
  • [Journal-full-title] Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
  • [ISO-abbreviation] Sichuan Da Xue Xue Bao Yi Xue Ban
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Triterpenes; EC 3.4.24.24 / MMP2 protein, human; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9; P3M2575F3F / ursolic acid
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45. Jain V, Gupta K, Kudva R, Rodrigues GS: A case of ovarian metastasis of gall bladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:319-21
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  • [Title] A case of ovarian metastasis of gall bladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature.
  • The ovary is a relatively frequent site of metastases from malignant neoplasia arising elsewhere in the body, the majority of these originating from the gastrointestinal tract.
  • The best-known tumor of this type is signet ring cell adenocarcinoma (Krukenberg tumor) of gastric origin and large bowel.
  • While clinical and imaging results suggested a primary ovarian carcinoma with incidental cholelithiasis and choledocholithiasis, the final diagnosis was obtained on the basis of histopathologic findings of resected specimen.
  • [MeSH-major] Adenocarcinoma / diagnosis. Gallbladder Neoplasms / diagnosis. Ovarian Neoplasms / diagnosis

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  • (PMID = 16515613.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q573I9DVLP / Leucovorin; U3P01618RT / Fluorouracil
  • [Number-of-references] 17
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46. Ishii Y, Itoh N, Takahashi A, Masumori N, Ikeda T, Tsukamoto T: Bladder cancer discovered by ovarian metastasis: cytokeratin expression is useful when making differential diagnosis. Int J Urol; 2005 Jan;12(1):104-7
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  • [Title] Bladder cancer discovered by ovarian metastasis: cytokeratin expression is useful when making differential diagnosis.
  • A 49-year-old woman underwent hysterectomy and bilateral adnexectomy after the diagnosis of a right ovarian tumor with paraaortic and pelvic lymph node metastases.
  • The pathological diagnosis was undifferentiated carcinoma of the ovary.
  • After the operation, a bladder tumor was discovered during the evaluation for microscopic hematuria.
  • The bladder tumor was pathologically diagnosed as transitional cell carcinoma, pT1b, G3.
  • Although the pathological findings of the bladder cancer and ovarian cancer were very similar, we could diagnose primary bladder cancer with ovary and lymph node metastases according to the immunohistochemical staining pattern of cytokeratins 7 and 20.
  • Herein, the clinical usefulness of immunohistochemical staining using cytokeratins for making a differential diagnosis of the origin of a tumor in the pelvic cavity is demonstrated.
  • [MeSH-major] Carcinoma, Transitional Cell / diagnosis. Carcinoma, Transitional Cell / metabolism. Intermediate Filament Proteins / metabolism. Keratins / metabolism. Urinary Bladder Neoplasms / diagnosis. Urinary Bladder Neoplasms / metabolism
  • [MeSH-minor] Biomarkers, Tumor / metabolism. Carcinoma / secondary. Carcinoma / therapy. Diagnosis, Differential. Female. Humans. Immunohistochemistry. Keratin-20. Keratin-7. Middle Aged. Ovarian Neoplasms / secondary. Ovarian Neoplasms / therapy

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  • (PMID = 15661064.001).
  • [ISSN] 0919-8172
  • [Journal-full-title] International journal of urology : official journal of the Japanese Urological Association
  • [ISO-abbreviation] Int. J. Urol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / Intermediate Filament Proteins; 0 / KRT20 protein, human; 0 / KRT7 protein, human; 0 / Keratin-20; 0 / Keratin-7; 68238-35-7 / Keratins
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47. Goto Y, Katsumata N, Nakai S, Sasajima Y, Yonemori K, Kouno T, Shimizu C, Ando M, Fujiwara Y: Leptomeningeal metastasis from ovarian carcinoma successfully treated by the intraventricular administration of methotrexate. Int J Clin Oncol; 2008 Dec;13(6):555-8
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  • [Title] Leptomeningeal metastasis from ovarian carcinoma successfully treated by the intraventricular administration of methotrexate.
  • A 60-year-old woman with a history of ovarian carcinoma and complaining of gait instability, dizziness, nausea, and a right temporal headache visited a neurologist.
  • A diagnosis of leptomeningeal metastasis was made, based on the results of a cerebrospinal fluid examination.
  • Although uncommon, the possibility of leptomeningeal metastasis from ovarian carcinoma should be considered; in such cases, treatment with intraventricular methotrexate may be effective and feasible and should be considered as a treatment strategy.
  • [MeSH-major] Antimetabolites, Antineoplastic / administration & dosage. Meningeal Neoplasms / drug therapy. Meningeal Neoplasms / secondary. Methotrexate / administration & dosage. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / pathology

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  • (PMID = 19093186.001).
  • [ISSN] 1341-9625
  • [Journal-full-title] International journal of clinical oncology
  • [ISO-abbreviation] Int. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; AU0V1LM3JT / Gadolinium; YL5FZ2Y5U1 / Methotrexate
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48. Jin H, Yu Y, Zhang T, Zhou X, Zhou J, Jia L, Wu Y, Zhou BP, Feng Y: Snail is critical for tumor growth and metastasis of ovarian carcinoma. Int J Cancer; 2010 May 1;126(9):2102-11
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  • [Title] Snail is critical for tumor growth and metastasis of ovarian carcinoma.
  • Snail, a key inducer of epithelial-mesenchymal transition (EMT), plays an important role in cancer metastasis.
  • To better understand the role of Snail in the metastasis of ovarian carcinoma, expression of Snail was knocked down by antisense-Snail in the highly metastatic ovarian cancer cell line HO8910PM.
  • These findings suggest that Snail interacts with MMP during tumor invasion and metastasis.
  • In addition, we examined the role of Snail in an ovarian cancer orthotopic model by using the antisense-Snail HO8910PM cell line.
  • We found that the size of primary ovarian cancer tumor and the number of metastatic lesions were significantly reduced when Snail was knocked down.
  • Confirming our initial findings, the activity of MMP2 was greatly inhibited in tumors from antisense-Snail cells.
  • Furthermore, immunohistochemical analysis on ovarian cancer progression tissue array demonstrated that the expression of Snail was significantly higher in metastatic lesions, and Snail expression correlated with the stage of ovarian cancer.
  • Interestingly, in early-stage tumors, Snail was localized in both the cytoplasm and nucleus.
  • In late stage and metastatic lesions, the level of Snail was elevated, and Snail was localized to the nucleus.
  • Overall, our study indicates that Snail plays a critical role in tumor growth and metastasis of ovarian carcinoma through regulation of MMP activity.
  • [MeSH-major] Ovarian Neoplasms / pathology. Transcription Factors / physiology
  • [MeSH-minor] Adult. Aged. Animals. Cadherins / analysis. Cell Line, Tumor. Cell Proliferation. Epithelium / pathology. Female. Humans. Matrix Metalloproteinase 2 / metabolism. Matrix Metalloproteinase 9 / metabolism. Mesoderm / pathology. Mice. Mice, Inbred BALB C. Middle Aged. Neoplasm Metastasis. Oligonucleotide Array Sequence Analysis. Tissue Inhibitor of Metalloproteinase-3 / physiology

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  • (PMID = 19795442.001).
  • [ISSN] 1097-0215
  • [Journal-full-title] International journal of cancer
  • [ISO-abbreviation] Int. J. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Cadherins; 0 / TIMP3 protein, human; 0 / Tissue Inhibitor of Metalloproteinase-3; 0 / Transcription Factors; 0 / snail family transcription factors; EC 3.4.24.24 / Matrix Metalloproteinase 2; EC 3.4.24.35 / Matrix Metalloproteinase 9
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49. Ebisui C, Ohkubo K, Akitake H, Ohtsuka M, Maekawa T, Yoshioka S, Hama N, Kashiwazaki M, Taniguchi M, Tsujie M, Konishi M, Fujimoto T: [A case of ovarian metastasis from colon cancer successfully treated with multidisciplinary therapy]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2542-4
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  • [Title] [A case of ovarian metastasis from colon cancer successfully treated with multidisciplinary therapy].
  • An 80-year-old female patient was undergone sigmoidectomy with D2 lymph node dissection for type 2 sigmoid colon cancer in February 2007.
  • A post operative pathological finding of cancer was SS, N0, P0, H0, M0 (Stage II), curative A.
  • CT scan and MRI revealed a mass of 10 cm in diameter with multiple cysts in the pelvic cavity, which was diagnosed a malignant ovarian tumor.
  • In May 2008, total hysterectomy, bilateral oophorectomy, and partial omentectomy were performed and its pathological finding was metastatic ovarian tumor originating from colon cancer.
  • Adjuvant chemotherapy was administered, as cancer cells were detected in the ascites.
  • [MeSH-major] Adenocarcinoma / pathology. Krukenberg Tumor / secondary. Krukenberg Tumor / therapy. Ovarian Neoplasms / secondary. Ovarian Neoplasms / therapy. Sigmoid Neoplasms / pathology

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  • (PMID = 21224633.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 56HH86ZVCT / Uracil; 5VT6420TIG / Oxonic Acid; 1-UFT protocol
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50. Dordević M, Mitrović S, Jovanović B, Dordević G: [Ovarian metastasis in patient with endometrial carcinoma or synchronous tumors--presentation of a case]. Med Pregl; 2010 Jul-Aug;63(7-8):570-3
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  • [Title] [Ovarian metastasis in patient with endometrial carcinoma or synchronous tumors--presentation of a case].
  • INTRODUCTION: Synchronous, independent tumors are two or more tumors which appear independently from each other at the same moment.
  • Metastatic tumors originate by disseminating malignant cells from other organs.
  • Joined endometrial and ovarian carcinomas are found in 5% of cases.
  • PRESENTATION OF A CASE: In this research, we present the case of an obese woman, 37 years old, who had associated endometrial tumors of uterus and ovary, without malign cells in peritoneal dilution, positive estrogen. negative progestine and focal expression of p53 receptors present in about 10-15% tumor cells.
  • The patient was without recurrence of the disease 30 months after the operation.
  • The differentiation of primary independent synchronous and metastatic tumors is important not only for the prognosis, but also for the choice of the therapy.
  • [MeSH-major] Adenocarcinoma / secondary. Endometrial Neoplasms / pathology. Neoplasms, Multiple Primary / pathology. Ovarian Neoplasms / secondary

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  • (PMID = 21446151.001).
  • [ISSN] 0025-8105
  • [Journal-full-title] Medicinski pregled
  • [ISO-abbreviation] Med. Pregl.
  • [Language] srp
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Serbia
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51. Wang SM, Li L, Zhang W, Li DR, Tang BJ: [Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells]. Zhonghua Fu Chan Ke Za Zhi; 2010 Aug;45(8):598-602
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  • [Title] [Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells].
  • OBJECTIVE: To clone cathepsin L (CTSL) gene and construct the eukaryotic expression plasmid pcDNA3.1-CTSL and study the relationship between CTSL and invasion and metastasis in ovarian cancer cells in vitro.
  • METHODS: The total RNA was extracted from the ovarian cancer tissue and the intact cDNA of CTSL was applied by reverse transcription (RT)-PCR.
  • The cell growth curves, clonogenicity efficiency were observed.
  • The cell cycles were measured by flow cytometer.
  • The ability of invasion, metastasis and adhesion of ovarian cancer cells were detected by the matrigel invasion assay, transwell migration assay and adhesion assay, respectively.
  • Result from RT-PCR and western blot showed that the ovarian cancer cells which transfected by recombinant plasmid could express CTSL gene and protein.
  • There was difference between HO8910-CTSL and HO8910-pcDNA3.1 cells in matrigel invasion ability (0.34 ± 0.18 versus 0.17 ± 0.04) and metastasis ability (1.252 ± 0.114 versus 0.486 ± 0.027) of cancer (all P < 0.05).
  • CONCLUSION: CTSL maybe increase the ability of invasion and metastasis of ovarian cancer cells in vitro, which may be a molecular target of blocking invasion and metastasis of ovarian cancer.
  • [MeSH-major] Cathepsin L / metabolism. Cell Movement. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology
  • [MeSH-minor] Cell Adhesion. Cell Line, Tumor. Cell Proliferation. DNA, Complementary / genetics. Female. Flow Cytometry. Gene Expression Regulation, Neoplastic. Genetic Vectors / genetics. Humans. Neoplasm Invasiveness. Neoplasm Metastasis. Plasmids / genetics. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Transfection

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  • (PMID = 21029616.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / DNA, Complementary; 0 / RNA, Messenger; EC 3.4.22.15 / Cathepsin L
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52. Yagi H, Yotsumoto F, Miyamoto S: Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition. Mol Cancer Ther; 2008 Oct;7(10):3441-51
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  • [Title] Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition.
  • Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is involved in several biological processes including cell adhesion, invasion, and angiogenesis.
  • HB-EGF also plays a pivotal role in the progression of ovarian cancer.
  • To investigate the significance of HB-EGF in peritoneal dissemination, we examined the roles of HB-EGF in cell adhesion, invasion, and angiogenesis in ovarian cancer.
  • Through the suppression of focal adhesion kinase and EGF receptor activation, cell adhesive properties mediated by integrin beta(1) were diminished by the inhibition of HB-EGF expression.
  • The reduction of HB-EGF expression attenuated the chemotactic invasive ability and the expression of matrix metalloprotease (MMP)-2 and vascular endothelial growth factor (VEGF), leading to the inhibition of cell invasion and angiogenesis.
  • Suppression of the Snail family, which regulates the epithelial-mesenchymal transition, blocked the cell adhesion properties on extracellular matrices, the chemotactic invasive ability, and the expression of MMP9 and VEGF through the reduction of HB-EGF expression.
  • The volume of tumor burden in the peritoneal cavity was dependent on the expression of HB-EGF.
  • According to these results, HB-EGF contributes to cell adhesion, invasion, and angiogenesis, which are integral to transcoelomic metastasis in ovarian cancer.
  • CRM197, an inhibitor of HB-EGF, resulted in a significant decrease of tumor burden in peritoneal dissemination, accompanied with a reduction in both cellular spreading, when assayed on an extracellular matrix, and invasive ability, when assayed in a chemotaxis chamber, as well as decreased expression of MMP9 and VEGF.
  • Thus, HB-EGF is a mutual validating target in the peritoneal dissemination of ovarian cancer, and CRM197 may be useful as a anticancer agent for advanced ovarian cancer.
  • [MeSH-major] Epithelium / pathology. Intercellular Signaling Peptides and Proteins / metabolism. Mesoderm / pathology. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Animals. Cell Adhesion / drug effects. Cell Line, Tumor. Collagen Type I / pharmacology. Collagen Type III / pharmacology. Female. Fibronectins / pharmacology. Gene Expression Regulation, Neoplastic / drug effects. Heparin-binding EGF-like Growth Factor. Humans. Ligands. Mice. Mice, Nude. Neoplasm Invasiveness. Neoplasm Metastasis. Neovascularization, Pathologic / metabolism. Receptor, Epidermal Growth Factor / metabolism. Signal Transduction / drug effects. Transcription Factors / genetics. Tumor Burden / drug effects

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  • (PMID = 18852147.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Collagen Type I; 0 / Collagen Type III; 0 / Fibronectins; 0 / HBEGF protein, human; 0 / Hbegf protein, mouse; 0 / Heparin-binding EGF-like Growth Factor; 0 / Intercellular Signaling Peptides and Proteins; 0 / Ligands; 0 / Transcription Factors; 0 / snail family transcription factors; EC 2.7.10.1 / Receptor, Epidermal Growth Factor
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53. Guan X, Li DR, Wang Q, Li L, Ruan HY, Zhang W: [Screening of differentially expressed proteins associated with directional highly lymphatic metastasis in ovarian carcinoma cell lines using SELDI-TOF-MS technology]. Ai Zheng; 2008 Nov;27(11):1155-60
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  • [Title] [Screening of differentially expressed proteins associated with directional highly lymphatic metastasis in ovarian carcinoma cell lines using SELDI-TOF-MS technology].
  • BACKGROUND & OBJECTIVE: The ovarian serous papillary adenocarcinoma cell line SKOV3 and its subclones SKOV3-pm2 and SKOV3-pm3 are cell models to investigate the molecular mechanism of invasion and metastasis of ovarian cancers.
  • This study was to screen differentially expressed proteins between ovarian carcinoma cell lines with directional (SKOV3-pm2 and SKOV3-pm3) and non-directional (SKOV3) highly lymphatic metastasis potentials using time-of-flight mass spectrometry technology and protein chips.
  • METHODS: The lymphatic metastasis rates of the three cell lines were detected in animal models.
  • Proteins in endochylema and supernatants of the three cell lines were screened using surface-enhanced laser desorption and ionization-time of flight-mass spectrometry (SELDI-TOF-MS).
  • RESULTS: Lymphatic metastasis rates in SKOV3, SKOV3-pm2 and SKOV3-pm3 cell xenografts in nude mice were 20%, 90% and 100%, respectively (P<0.05).
  • CONCLUSION: Combined with weak cation exchange protein chip assay and immobilized metal affinity capture SELDI ProteinChip array, SELDI-TOF-MS technology can be used to screen and identify differentially expressed proteins associated with directional highly lymphatic metastasis in ovarian carcinoma cell lines.
  • [MeSH-major] Lymphatic Metastasis. Neoplasm Proteins / analysis. Ovarian Neoplasms. Proteome / analysis
  • [MeSH-minor] Animals. Cell Line, Tumor. Female. Humans. Mice. Mice, Nude. Neoplasm Transplantation. Protein Array Analysis / methods. Proteomics / methods. Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods

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  • (PMID = 19000445.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Neoplasm Proteins; 0 / Proteome
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54. Munakata R, Sawair FA, Cheng J, Saku T: Gingival metastasis of ovarian carcinoma: report of a case and review of the literature. Int J Oral Maxillofac Surg; 2009 Oct;38(10):1123-6
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  • [Title] Gingival metastasis of ovarian carcinoma: report of a case and review of the literature.
  • The authors report an unusual case of metastatic ovarian carcinoma in the gingiva of a 46-year-old woman 5 years after ovariectomy.
  • The tumor presented as an exophytic growth at the molar region of the mandible.
  • Tumor cells were immunopositive for carcinoembryonic antigen, MUC1 mucin, and lysozyme, while stromal fibroblasts were immunopositive for vimentin and estrogen receptor.
  • The diagnosis of metastatic ovarian mucinous cystadenocarcinoma was made.
  • A review of the English literature revealed this to be the first report of gingival metastasis of an ovarian carcinoma.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / secondary. Gingival Neoplasms / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 19505797.001).
  • [ISSN] 1399-0020
  • [Journal-full-title] International journal of oral and maxillofacial surgery
  • [ISO-abbreviation] Int J Oral Maxillofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] Denmark
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 0 / Mucin-1; 0 / Receptors, Estrogen; 0 / Vimentin
  • [Number-of-references] 27
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55. Pekmezci S, Saribeyoglu K, Aytac E, Arvas M, Demirkiran F, Ozguroglu M: Surgery for isolated liver metastasis of ovarian cancer. Asian J Surg; 2010 Apr;33(2):83-8
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  • [Title] Surgery for isolated liver metastasis of ovarian cancer.
  • BACKGROUND: Few studies have been published on liver resection alone or in combination with cytoreductive surgery for liver metastases of ovarian carcinoma.
  • METHODS: Eight patients who underwent liver resection for metastasis of ovarian cancer were included in the study.
  • The demographic data, follow-up details before and after liver resection, histopathology of the primary ovarian cancer, type of surgery and outcome were evaluated.
  • The mean disease-free interval was 5.38 years from the time of initial surgery to surgery for metastatic liver lesions, and 39 months after liver resection to secondary metastases.
  • Four patients did not have any evidence of disease after liver surgery.
  • CONCLUSION: Indications for liver resection should be considered in selected patients who have a limited extent of metastatic disease from ovarian carcinoma.
  • Liver resection for metastases of ovarian carcinoma could be an effective and feasible approach.

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  • [Copyright] Copyright © 2010 Asian Surgical Association. Published by Elsevier B.V. All rights reserved.
  • (PMID = 21029944.001).
  • [ISSN] 0219-3108
  • [Journal-full-title] Asian journal of surgery
  • [ISO-abbreviation] Asian J Surg
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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56. Hasegawa H, Naitoh H, Tsuchihashi H, Okada K, Furukawa H, Hanasawa K: [A case of solitary splenic metastasis from an ovarian cancer 12 years after primary resection]. Gan To Kagaku Ryoho; 2010 Sep;37(9):1799-803
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  • [Title] [A case of solitary splenic metastasis from an ovarian cancer 12 years after primary resection].
  • A 57-year-old woman underwent total hysterectomy and bilateral salpingo-oophorectomy for bilateral ovarian tumors (T1b, N0, M0; Stage I b, serous cystoadenocarcinoma) in May 1994.
  • Since whole-body FDG-PET-CT showed no evidence of local recurrence of the ovarian cancer or multiple organ metastases, a solitary splenic metastasis from ovarian cancer, even though very rare, was strongly suspected.
  • Histopathological examination revealed poorly-differentiated adenocarcinoma, suggesting the final diagnosis of solitary splenic metastasis from ovarian cancer.
  • Periodic CA125 measurements are considered very important even over 10 years after surgery for ovarian cancer.
  • Once solitary splenic metastasis is diagnosed, surgical resection would be the treatment of choice.
  • [MeSH-major] Ovarian Neoplasms / pathology. Splenic Neoplasms / secondary

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  • (PMID = 20841951.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Japan
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57. Lalich D, Tawfik O, Chapman J, Fraga G: Cutaneous metastasis of ovarian carcinoma with shadow cells mimicking a primary pilomatrical neoplasm. Am J Dermatopathol; 2010 Jul;32(5):500-4
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  • [Title] Cutaneous metastasis of ovarian carcinoma with shadow cells mimicking a primary pilomatrical neoplasm.
  • We describe a metastasis of an ovarian endometrioid adenocarcinoma with shadow cells to the skin that was initially misinterpreted as a pilomatricoma.
  • We compare the histology of the ovarian neoplasm to 21 pilomatricomas.
  • This is the first reported case of a cutaneous metastasis of a visceral neoplasm mimicking a primary pilomatrical neoplasm.
  • [MeSH-major] Carcinoma, Endometrioid / secondary. Ovarian Neoplasms / pathology. Pilomatrixoma / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Arm. Biopsy. Cell Differentiation. Diagnosis, Differential. Female. Humans. Ovariectomy. Ovary / pathology. Skin / pathology

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  • (PMID = 20526175.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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58. Delotte J, Ferron G, Kuei TL, Mery E, Gladieff L, Querleu D: Laparoscopic management of an isolated ovarian metastasis on a transposed ovary in a patient treated for stage IB1 adenocarcinoma of the cervix. J Minim Invasive Gynecol; 2009 Jan-Feb;16(1):106-8
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  • [Title] Laparoscopic management of an isolated ovarian metastasis on a transposed ovary in a patient treated for stage IB1 adenocarcinoma of the cervix.
  • Transposition of the ovaries is performed frequently in young women with early-stage cervical cancer.
  • However, this must be balanced with the risks of ovarian metastases especially in patients with adenocarcinomas.
  • We report the first case of laparoscopic management of an isolated metastasis to a transposed ovary that occurred 2 years after primary laparoscopic treatment of a stage IB1 adenocarcinoma of the cervix.
  • [MeSH-major] Adenocarcinoma / surgery. Laparoscopy / methods. Lymph Node Excision. Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery. Ovariectomy / methods. Uterine Cervical Neoplasms / pathology


59. Abe Y, Takeuchi M, Matsuzaki K, Uehara H, Furumoto H, Nishitani H: A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging. Jpn J Radiol; 2009 Dec;27(10):458-61
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  • [Title] A case of metastatic malignant melanoma of the ovary with a multilocular cystic appearance on MR imaging.
  • Ovarian metastasis from malignant melanoma is rare and usually appears as a solid ovarian mass.
  • We report a case of ovarian metastasis from cutaneous malignant melanoma that proved to be a diagnostic dilemma.
  • The ovarian metastasis exhibited a multilocular cystic appearance on magnetic resonance imaging, mimicking a mucinous ovarian tumor with massive ascites.
  • [MeSH-major] Magnetic Resonance Imaging. Melanoma, Amelanotic / diagnosis. Melanoma, Amelanotic / secondary. Ovarian Cysts / diagnosis. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary. Skin Neoplasms / pathology
  • [MeSH-minor] Adult. Ascites / etiology. Diagnosis, Differential. Fatal Outcome. Female. Gadolinium. Humans. Melanoma / diagnosis. Melanoma / secondary. Time Factors. Treatment Outcome


60. Stippel DL, Kasper HU, Schleimer K, Töx U, Bangard C, Hölscher AH, Beckurts KT: Successful use of sirolimus in a patient with bulky ovarian metastasis of hepatocellular carcinoma after liver transplantation. Transplant Proc; 2005 Jun;37(5):2185-7
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  • [Title] Successful use of sirolimus in a patient with bulky ovarian metastasis of hepatocellular carcinoma after liver transplantation.
  • This 44-year-old woman developed multifocal hepatocellular carcinoma (HCC) within hepatitis B-induced liver cirrhosis.
  • Five months after transplantation bilateral bulky ovarian metastases were seen on computed tomography (CT) scan.
  • In conclusion, radical surgical treatment and immunosuppression using sirolimus may achieve tumor-free survival in selected patients with advanced or recurrent HCC.
  • [MeSH-major] Antibiotics, Antineoplastic / therapeutic use. Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery. Liver Transplantation. Ovarian Neoplasms / drug therapy. Ovarian Neoplasms / secondary. Sirolimus / therapeutic use


61. Wang Y, Yang J, Gao Y, Zhao XL, Li HZ, Yao Z: [Relationship between raf kinase inhibitor protein and metastasis of ovarian carcinoma]. Zhonghua Fu Chan Ke Za Zhi; 2009 Jul;44(7):522-8
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  • [Title] [Relationship between raf kinase inhibitor protein and metastasis of ovarian carcinoma].
  • OBJECTIVE: To investigate the relationship between raf kinase inhibitor protein (RKIP), a novel metastasis suppressor gene, and metastasis of ovarian carcinoma.
  • METHODS: Immunohistochemistry, RT-PCR, and western blot analysis were performed to examine the expression of RKIP in clinical samples of ovarian tumors and five human ovarian carcinoma cell lines.
  • Stable cell lines over-expressed or deleted of RKIP were cloned to investigate the function of RKIP in ovarian cancer cells.
  • The recombinant plasmids expressing sense (ss) or antisense (as) RKIP cDNA or empty vector was transfected into ovarian cancer cell line SKOV3 by lipofectamine.
  • The expression level of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and extracellular signal-regulated kinase (ERK) in ovarian cancer cells were detected by western blot analysis.
  • Assays of cell proliferation, soft-agar colony formation, cell adhesion, and cell invasion in vitro were used to examine the malignant phenotypes of the transfected cells.
  • Flow cytometric analysis was performed to observe the effect of RKIP on cell cycle distribution before and after transfection. RESULTS:.
  • (1) The expression levels of RKIP protein in ovarian carcinoma tissues from patients were found to be reduced than those in ovarian benign tumor and borderline tumor.
  • SKOV3 clones stably expressing full-length recombinant ssRKIP, asRKIP, and their respective empty vector were obtained. (2) RKIP was able to block basal levels of MEK and ERK in ovarian cancer cells.
  • 48 and 0.46. (3) Abilities of cell proliferation in the ssRKIP vector-transfected cells were decreased compared with that in the non-transfected cells (P < 0.01). (4)Anchorage-independent growth in the ssRKIP#1 and ssRKIP#4 cells (83.7 +/- 5.7, 106.0 +/- 9.2) were decreased compared with that in the empty vector-transfected cells (158.3 +/- 14.6, P < 0.01). (5)Cell adhesion in the ssRKIP#1 and ssRKIP#4 cells [(68.3 +/- 0.8)%, (64.1 +/- 0.9)%] were decreased compared with that in the non-transfected cells [(100.0 +/- 1.1)%, P < 0.01]. (6) Cell invasion in the ssRKIP#1 and ssRKIP#4 cells (24 +/- 5, 25 +/- 4) were decreased compared with that in the non-transfected cells (68 +/- 5, P < 0.01). (7) ssRKIP cells had a significant increase in the G1 phase and decrease in the G2 + S phase.
  • CONCLUSION: RKIP could inhibits the metastasis, but also the growth of ovarian cancer cells. patients were found to be reduced than those in ovarian benign tumor and borderline tumor.
  • SKOV3 clones stably expressing full-length recombinant ssRKIP, asRKIP, and their respective empty vector were obtained. (2) RKIP was able to block basal levels of MEK and ERK in ovarian cancer cells.
  • The expression level of phosphorylation MEK in ssRKIP#1 and ssRKIP#4 cells were 0.35, 0.34; while the expression level of phosphorylation ERK in ssRKIP #1 and ssRKIP #4 cells were 0.48 and 0.46. (3) Abilities of cell proliferation in the ssRKIP vector-transfected cells were decreased compared with that in the non-transfected cells (P < 0.01). (4) Anchorage-independent growth in the ssRKIP#1 and ssRKIP#4 cells (83.7 +/- 5.7, 106.0 +/- 9.2) were decreased compared with that in the empty vector-transfected cells (158.3 +/- 14.6, P < 0.01). (5) Cell adhesion in the ssRKIP#1 and ssRKIP#4 cells [(68.3 +/- 0.8)%, (64.1 +/- 0.9)%] were decreased compared with that in the non-transfected cells [(100.0 +/- 1.1)%, P < 0.01]. (6) Cell invasion in the ssRKIP#1 and ssRKIP#4 cells (24 +/- 5, 25 +/- 4) were decreased compared with that in the nontransfected cells (68 +/- 5, P < 0.01). (7) ssRKIP cells had a significant increase in the G1 phase and decrease in the G2 + S phase.
  • CONCLUSION: RKIP could inhibits the metastasis, but also the growth of ovarian cancer cells.
  • [MeSH-major] Extracellular Signal-Regulated MAP Kinases / metabolism. Mitogen-Activated Protein Kinase Kinases / metabolism. Ovarian Neoplasms / metabolism. Ovarian Neoplasms / pathology. Phosphatidylethanolamine Binding Protein / metabolism
  • [MeSH-minor] Adolescent. Adult. Aged. Cell Line, Tumor. Cell Proliferation. Female. Genes, Tumor Suppressor. Genetic Vectors. Humans. Immunohistochemistry. Middle Aged. Neoplasm Invasiveness. Neoplasm Metastasis. Phosphorylation. RNA, Messenger / genetics. RNA, Messenger / metabolism. Reverse Transcriptase Polymerase Chain Reaction. Transfection. Young Adult

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  • (PMID = 19957553.001).
  • [ISSN] 0529-567X
  • [Journal-full-title] Zhonghua fu chan ke za zhi
  • [ISO-abbreviation] Zhonghua Fu Chan Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Phosphatidylethanolamine Binding Protein; 0 / RNA, Messenger; EC 2.7.11.24 / Extracellular Signal-Regulated MAP Kinases; EC 2.7.12.2 / Mitogen-Activated Protein Kinase Kinases
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62. Chiu TJ, Chen YJ, Huang CH: Massive anterior chest wall metastasis of ovarian cancer and prolonged survival after treatment: a case report. J Reprod Med; 2008 May;53(5):373-7
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  • [Title] Massive anterior chest wall metastasis of ovarian cancer and prolonged survival after treatment: a case report.
  • BACKGROUND: Although previously uncommon, distant metastases of ovarian cancer are now observed with increasing frequency.
  • CASE: A 51-year-old woman presented with a massive metastatic tumor of the anterior chest wall 10 years after receiving total abdominal hysterectomy and bilateral salpingo-oophorectomy for primary ovarian cancer.
  • The extremely large size of the tumor precluded surgical resection.
  • CONCLUSION: This report is the first to describe a case of a massive, inoperable chest wall tumor developing as a late metastasis of ovarian cancer.
  • [MeSH-major] Carcinoma, Papillary / secondary. Carcinoma, Papillary / therapy. Ovarian Neoplasms / pathology. Thoracic Neoplasms / secondary. Thoracic Neoplasms / therapy. Thoracic Wall

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  • (PMID = 18567287.001).
  • [ISSN] 0024-7758
  • [Journal-full-title] The Journal of reproductive medicine
  • [ISO-abbreviation] J Reprod Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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63. Ayhan A, Guvenal T, Salman MC, Ozyuncu O, Sakinci M, Basaran M: The role of cytoreductive surgery in nongenital cancers metastatic to the ovaries. Gynecol Oncol; 2005 Aug;98(2):235-41
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  • [Title] The role of cytoreductive surgery in nongenital cancers metastatic to the ovaries.
  • OBJECTIVE: To investigate the role of cytoreductive surgery in patients with nongenital cancers metastatic to the ovaries.
  • PATIENTS AND METHODS: One hundred and fifty-four patients with nongenital cancers metastatic to the ovaries treated in Hacettepe University Hospital, Gynecologic Oncology Unit between 1982 and 2004 years were retrospectively evaluated.
  • RESULTS: During study period, nongenital cancers metastatic to the ovaries constituted 9% of all malignant ovarian neoplasms.
  • Primary cancers were breast (35), stomach (35) and colorectal (33) cancers, lymphoma (17), undetermined origin (16), appendix (7), ileum (4), pancreas (3), gallbladder cancer (2) and mesothelioma (2).
  • CONCLUSION: Presence of ovarian metastasis is associated with a poor prognosis in nongenital cancers.
  • Surgery is essential for diagnosis of primary tumor and necessary for relief of symptoms.
  • Cytoreductive surgery seems to have a beneficial effect on survival of selected patients, especially for patients with colorectal cancer metastatic to the ovary.
  • [MeSH-major] Ovarian Neoplasms / secondary. Ovarian Neoplasms / surgery

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  • (PMID = 15982725.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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64. Gubbels JA, Belisle J, Onda M, Rancourt C, Migneault M, Ho M, Bera TK, Connor J, Sathyanarayana BK, Lee B, Pastan I, Patankar MS: Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Mol Cancer; 2006 Oct 26;5(1):50
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  • [Title] Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors.
  • BACKGROUND: The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors.
  • Here we have addressed this deficit and provide further evidence supporting the role of the MUC16-mesothelin interaction in facilitating cell-cell binding under conditions that mimic the peritoneal environment.
  • RESULTS: In this study we utilize recombinant-Fc tagged human mesothelin to measure the binding kinetics of this glycoprotein to MUC16 expressed on the ovarian tumor cell line OVCAR-3.
  • We also demonstrate that MUC16 positive ovarian tumor cells exhibit increased adherence to A431 cells transfected with mesothelin (A431-Meso+).
  • The binding between the MUC16 expressing ovarian tumor cells and the A431-Meso+ cells occurs even in the presence of ascites from patients with ovarian cancer.
  • CONCLUSION: The strong binding kinetics of the mesothelin-MUC16 interaction and the cell adhesion between ovarian tumor cells and A431-Meso+ even in the presence of peritoneal fluid strongly support the importance of these two glycoproteins in the peritoneal metastasis of ovarian tumors.
  • The demonstration that N-linked glycans are essential for mediating mesothlein-MUC16 binding may lead to novel therapeutic targets to control the spread of ovarian carcinoma.

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  • (PMID = 17067392.001).
  • [ISSN] 1476-4598
  • [Journal-full-title] Molecular cancer
  • [ISO-abbreviation] Mol. Cancer
  • [Language] ENG
  • [Grant] United States / Intramural NIH HHS / /
  • [Publication-type] Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / GPI-Linked Proteins; 0 / MUC16 protein, human; 0 / Membrane Glycoproteins; 0 / Membrane Proteins; 0 / Polysaccharides; 0 / mesothelin
  • [Other-IDs] NLM/ PMC1635730
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65. Maâouni S, Benaddi L, Kabbaj N, Errabih I, Alhamany Z, Benaïssa A: [Krukenberg tumor: rare metastasis of hilar cholangiocarcinoma]. Presse Med; 2006 Jul-Aug;35(7-8):1181-4
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  • [Title] [Krukenberg tumor: rare metastasis of hilar cholangiocarcinoma].
  • [Transliterated title] Une métastase rare du cholangiocarcinome hilaire, la tumeur de Krukenberg.
  • INTRODUCTION: Hilar cholangiocarcinoma is a rare cancer revealed in this case only after its ovarian metastasis, a Krukenberg tumor.
  • Her medical history included a hysterectomy eight months earlier for a Krukenberg tumor.
  • The primary tumor had never been found.
  • Surgery discovered an extensive unresectable tumor of the proximal principal bile duct.
  • The histology study found adenocarcinoma of the bile duct, and concluded that the Krukenberg tumor was secondary to this cholangiocarcinoma.
  • Ovarian metastasis of hilar cholangiocarcinoma is very rare.
  • [MeSH-major] Bile Duct Neoplasms / pathology. Bile Ducts, Intrahepatic. Cholangiocarcinoma / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adenocarcinoma / pathology. Female. Humans. Middle Aged. Neoplasm Metastasis. Tomography, X-Ray Computed

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  • (PMID = 16840896.001).
  • [ISSN] 0755-4982
  • [Journal-full-title] Presse medicale (Paris, France : 1983)
  • [ISO-abbreviation] Presse Med
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
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66. Sasaki H, Ohara N, Minamikawa T, Umeda M, Komori T, Kojima N, Takemura N, Morita H, Sugihara R, Enoki E, Itoh T: Gingival metastasis from ovarian mucinous cystadenocarcinoma as an initial manifestation (a rare case report). Kobe J Med Sci; 2008;54(3):E174-82
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  • [Title] Gingival metastasis from ovarian mucinous cystadenocarcinoma as an initial manifestation (a rare case report).
  • The metastasis of malignant tumors to the oral cavity remains a rare clinical entity.
  • Most metastatic tumors have the propensity for involving the mandible rather than the oral soft tissues.
  • Herein, we describe an unusual case of ovarian mucinous cystadenocarcinoma that metastasized to the mandibular gingiva as an initial manifestation.
  • There is little information regarding metastatic ovarian cancer to the oral cavity.
  • A biopsy taken from the gingiva showed mucinous adenocarcinoma, indicating the gingival metastasis of undiscovered primary cancer.
  • A positron emission tomography and computed tomography using 18F-fluorodeoxyglucose depicted an ovarian tumor with multiple pelvic and paraaortic lymph node swellings.
  • A magnetic resonance imaging (MRI) clearly demonstrated the presence of an ovarian cancer.
  • Based on the imaging studies, the diagnosis of the gingival metastasis of an ovarian cancer was suspected.
  • The histology of surgical specimen confirmed the gingival metastasis of ovarian mucinous adenocarcinoma.
  • This case emphasizes that although rare, metastatic ovarian cancer to the gingiva should be included in the differential diagnosis of tumors in the oral cavity.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / pathology. Gingival Neoplasms / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 19246966.001).
  • [ISSN] 1883-0498
  • [Journal-full-title] The Kobe journal of medical sciences
  • [ISO-abbreviation] Kobe J Med Sci
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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67. Demirci S, Yavas F, Ozsaran Z, Ozsaran A, Dikmen Y, Zekioglu O, Karabulut B, Aras AB: Palliative radiotherapy for the skin metastasis of ovarian cancer: a case report and review of the literature. Med Oncol; 2010 Sep;27(3):628-31
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  • [Title] Palliative radiotherapy for the skin metastasis of ovarian cancer: a case report and review of the literature.
  • Ovarian cancer which is the most common cause of death among all gynecological malignancies tends to metastasize through peritoneal cavity.
  • Skin metastasis, however, is a very rare clinical entity and related with poor prognosis.
  • We report a 43-year-old patient with recurrent ovarian cancer presented with extensive abdominal skin metastasis approximately 6 years after the initial diagnosis.
  • Skin metastasis showed good response to radiotherapy, and the patient has been alive for 7 months after radiotherapy with no recurrences on abdominal skin.
  • Radiotherapy might be considered as an efficient palliative treatment option for the skin metastasis of ovarian cancer.
  • [MeSH-major] Cystadenocarcinoma, Papillary / radiotherapy. Cystadenocarcinoma, Serous / radiotherapy. Ovarian Neoplasms / pathology. Radiotherapy, High-Energy. Skin Neoplasms / radiotherapy. Skin Neoplasms / secondary

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  • (PMID = 19536657.001).
  • [ISSN] 1559-131X
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
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68. Mijinyawa MS, Sani MU, Yusuf SM, Mohammed AZ, Alhassan SU: Krukenberg's tumour. Niger J Med; 2009 Oct-Dec;18(4):416-9
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  • [Title] Krukenberg's tumour.
  • BACKGROUND: Krukenburg's tumour, a metastatic cancer to the ovary can pose difficulties in early diagnosis.
  • METHODS: We present a 32-year-old lady who presented with mucoid and bloody diarrhoea associated with menstrual irregularity, weight loss and lower abdominal pains 2 years after surgical treatment for gastric cancer.
  • Literature on Krukenburg's tumour was also reviewed.
  • The histology of the colonic lesion showed signet ring carcinoma while the enlarged ovaries turned out to have evidence of metastatic adenocarcinoma.
  • CONCLUSION: Early diagnosis of KT can be difficult.
  • [MeSH-major] Adenocarcinoma / secondary. Carcinoma, Signet Ring Cell / secondary. Colonic Neoplasms / secondary. Ovarian Neoplasms / secondary. Stomach Neoplasms / pathology
  • [MeSH-minor] Adult. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 20120149.001).
  • [ISSN] 1115-2613
  • [Journal-full-title] Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria
  • [ISO-abbreviation] Niger J Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Nigeria
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69. Dursun P, Yanik FB, Kuscu E, Gultekin M, Ayhan A: Bilateral breast metastasis of ovarian carcinoma. Eur J Gynaecol Oncol; 2009;30(1):9-12
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  • [Title] Bilateral breast metastasis of ovarian carcinoma.
  • Primary breast carcinoma is the most common malignancy in women, however, metastatic breast carcinoma is rarely seen in clinical practice.
  • On the other hand, ovarian carcinoma and other gynecologic cancers rarely develop into breast metastasis.
  • However, the incidence of breast metastasis arising from ovarian carcinoma might be increasing as a result of prolongation in survival and improvement in treatment modalities.
  • Bilateral breast metastasis originating from an ovarian carcinoma is an extremely rare clinico-pathological situation.
  • In our literature review we found just nine cases of bilateral breast metastasis from primary ovarian carcinoma.
  • Mean interval from initial diagnosis of ovarian carcinoma to bilateral breast metastases was 22 months (range 11-24) and mean survival was 12 (range 5-27) months after the diagnosis of breast metastasis.
  • Serous papillary adenocarcinoma was the predominant histological subtype.
  • In conclusion, although it is a rare entity, breast metastasis should not be ruled out in patients with a history of ovarian carcinoma, if patients present with any symptoms of breast diseases.
  • [MeSH-major] Adenocarcinoma, Papillary / secondary. Breast Neoplasms / secondary. Cystadenocarcinoma, Serous / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 19317248.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Italy
  • [Number-of-references] 32
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70. Klein RL, Brown AR, Gomez-Castro CM, Chambers SK, Cragun JM, Grasso-Lebeau L, Lang JE: Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: a case report and literature review. J Cancer; 2010;1:27-31
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  • [Title] Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: a case report and literature review.
  • Background. Primary ovarian carcinoma with metastasis to the breast is rare, with only 39 cases reported in the current literature.
  • Ovarian metastasis to the breast presenting as inflammatory breast carcinoma is even more infrequent, with only 6 cases reported.Case.
  • We present a patient who developed metastatic inflammatory cancer of the breast from a stage IIIC papillary serous ovarian adenocarcinoma approximately 1 year after the original diagnosis.
  • Pathologic analysis confirmed the origin of the tumor: a high-grade adenocarcinoma morphologically similar to the previously diagnosed ovarian cancer.
  • In addition, the tumor was strongly positive on immunohistochemistry for CA-125, identical to the ovarian primary.
  • The patient died of diffuse metastasis 5 months after the breast tumor was noted.Conclusion.
  • Although ovarian metastasis to the breast presenting as inflammatory breast cancer is rare, it should be included in the differential diagnosis for any patient with a personal history of ovarian cancer.
  • Accurate differentiation is necessary because treatment differs significantly for patients with ovarian metastasis to the breast, as compared with patients with primary inflammatory breast cancer.
  • Ovarian metastasis to the breast confers a poor prognosis: patient survival ranged from 3 to 18 months, with a median survival of 6 months after the diagnosis of the breast metastasis.

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  • (PMID = 20842221.001).
  • [ISSN] 1837-9664
  • [Journal-full-title] Journal of Cancer
  • [ISO-abbreviation] J Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Australia
  • [Other-IDs] NLM/ PMC2931350
  • [Keywords] NOTNLM ; breast cancer / breast cancer metastasis / inflammatory breast cancer / ovarian cancer / ovarian cancer metastasis
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71. Ishii M, Ishibashi K, Sobajima J, Ohsawa T, Okada N, Kumamoto K, Haga N, Yokoyama M, Ishida H: [Pseudo-Meigs' syndrome caused by ovarium metastasis from colorectal cancer]. Gan To Kagaku Ryoho; 2010 Nov;37(12):2591-3
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  • [Title] [Pseudo-Meigs' syndrome caused by ovarium metastasis from colorectal cancer].
  • Pseudo-Meigs' syndrome caused by ovarian metastasis from colorectal cancer is extremely rare.
  • The clinical symptoms of pleural effusion and ascites that are characteristics of pseudo-Meigs' syndrome are quite similar to those of terminal-stage colon cancer.
  • We investigated the prognosis and clinicopathological factors including age, location of the primary cancer, histology, wall depth, curative degree, synchronous/metachronous, unilateral/bilateral, lymph node metastasis, peritoneal dissemination, serum CEA level, venous invasion, and lymphatic invasion, in 5 cases of pseudo-Meigs' syndrome (PM group) and compared these findings with those of 10 cases with ovarian metastasis from colorectal cancer (control group) without pseudo-Meigs' syndrome.
  • However, we found that the surgical resection of ovarian metastasis in patients with pseudo-Meigs' syndrome improved the prognosis, similar to the situation for ovarian metastasis from colorectal cancer.
  • [MeSH-major] Colorectal Neoplasms / pathology. Meigs Syndrome / diagnosis. Meigs Syndrome / etiology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Middle Aged

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  • (PMID = 21224649.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Comparative Study; English Abstract; Journal Article
  • [Publication-country] Japan
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72. Furukawa N: Solitary splenic metastasis of ovarian cancer. Arch Gynecol Obstet; 2007 Jun;275(6):499-502
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  • [Title] Solitary splenic metastasis of ovarian cancer.
  • BACKGROUND: Solitary splenic metastasis occurs relatively rarely in ovarian cancer.
  • CASE REPORT: This report presents a patient in whom a solitary splenic metastasis was detected 9 years after diagnosis of stage Ic ovarian cancer.
  • The patient was a 59-year-old woman who was diagnosed with stage Ic ovarian serous cystadenocarcinoma in 1992, underwent postoperative chemotherapy, and exhibited no signs of recurrence in terms of clinical symptoms, markers and imaging findings.
  • Magnetic resonance imaging (MRI) suggested a malignant splenic tumor and CA125 levels were elevated at 485 U/ml.
  • The patient underwent a splenectomy and microscopy confirmed the splenic tumor to be of the same histological type as the ovarian cancer.
  • At present (60 months post splenectomy), the patient remains disease-free.
  • [MeSH-major] Cystadenocarcinoma, Serous / secondary. Ovarian Neoplasms / pathology. Splenic Neoplasms / secondary

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  • (PMID = 17096159.001).
  • [ISSN] 0932-0067
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-125 Antigen
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73. Roque R, Pina A, Soares C, Martinho A, Messias H: [Splenic metastasis in ovary serous adenocarcinoma]. Acta Med Port; 2007 Nov-Dec;20(6):581-6
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  • [Title] [Splenic metastasis in ovary serous adenocarcinoma].
  • [Transliterated title] Metástases esplénicas no adenocarcinoma seroso do ovário.
  • Splenic metastasis is rare, and is usually associated with disseminated malignancy.
  • The primary tumours more frequently related with splenic metastasis are lung, breast, gynaecologic, specially ovary tumours, colon, rectum and melanoma.
  • Isolated secondary splenic disease is rare, but it is described, often associated to ovary cancer.
  • We report a 55 years old women with parenchymal splenic metastases of serous ovary cystadenocarcinoma in the 5th follow up year.
  • This patient had positive peritoneal washings chytology but not macroscopic disease.
  • We discuss the secondary splenic involvement of ovary cancer, dissemination route, prognosis and role of splenectomy as treatment modality in this unusual recurrence site in ovary cancers.
  • [MeSH-major] Cystadenocarcinoma, Serous / secondary. Ovarian Neoplasms / pathology. Splenic Neoplasms / secondary

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  • (PMID = 18331703.001).
  • [ISSN] 1646-0758
  • [Journal-full-title] Acta médica portuguesa
  • [ISO-abbreviation] Acta Med Port
  • [Language] por
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Portugal
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74. Tan DS, Agarwal R, Kaye SB: Mechanisms of transcoelomic metastasis in ovarian cancer. Lancet Oncol; 2006 Nov;7(11):925-34
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  • [Title] Mechanisms of transcoelomic metastasis in ovarian cancer.
  • Metastasis from epithelial ovarian cancer can occur via the transcoelomic, haematogeneous, or lymphatic route.
  • Of these, transcoelomic metastasis is the most common, and is responsible for the greatest morbidity and mortality in women with this disease.
  • The mechanisms of cell detachment, migration, and implantation in transcoelomic metastasis are placed within the context of clinical observations of ovarian cancer to derive a stepwise hypothesis of this process.
  • Evidence for transcoelomic dissemination versus transcoelomic metaplasia in ovarian cancer is presented.
  • Future high throughput microarray studies that compare changes at a genomic and gene expression level between primary ovarian tumours and their peritoneal metastases are hoped to lead to a more conclusive picture of transcoelomic metastasis, and to delineate the key molecular players in this process.
  • These studies might also result in the identification of potential new therapeutic targets in ovarian cancer.
  • [MeSH-major] Neoplasm Invasiveness / pathology. Neoplasm Metastasis. Ovarian Neoplasms / pathology

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  • (PMID = 17081918.001).
  • [ISSN] 1470-2045
  • [Journal-full-title] The Lancet. Oncology
  • [ISO-abbreviation] Lancet Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Number-of-references] 85
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75. Skírnisdóttir I, Garmo H, Holmberg L: Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990-2003: occurrence, origin and survival compared to ovarian cancer. Gynecol Oncol; 2007 Apr;105(1):166-71
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  • [Title] Non-genital tract metastases to the ovaries presented as ovarian tumors in Sweden 1990-2003: occurrence, origin and survival compared to ovarian cancer.
  • OBJECTIVE: The aim of this register study was to determine occurrence of non-genital ovarian metastasis detected by gynecologic surgery presented as ovarian neoplasm in Sweden from 1 January 1990 to 31 December 2003.
  • Age at diagnosis, survival for ovarian metastasis compared to ovarian cancer and prognostic factors were evaluated.
  • METHODS: Utilizing the population-based Swedish In-Patient Registry, Cancer Registry and Causes of Death Registry, we identified 255 cases with non-genital tract metastases to the ovaries detected at gynecological surgery.
  • During the study period, 10,955 newly diagnosed cases of ovarian cancer were reported to the Swedish Cancer Registry.
  • RESULTS: The proportion of ovarian metastases detected at surgery of all ovarian neoplasm increased from 1.7% to 3.0% during the study period.
  • The patients with ovarian metastasis of non-GI origin were younger than patients with primary ovarian cancer.
  • The most common primary diseases were breast cancer (29%), colon cancer (27%) and gastric cancer (16%).
  • Ovarian metastasis of GI origin preceded primary diagnosis in 51% of patients but for women with disease of non-GI origin the primary diagnosis was made in 18% of patients after surgery.
  • Five-year survival for patients with ovarian metastasis of GI origin was 11% and it was 24% if metastases were of non-GI origin.
  • Five-year survival for women with ovarian metastases from breast cancer was 26%.
  • In a multivariate analysis, GI surgery at primary surgery for ovarian metastasis was unfavorable prognostic factor.
  • Diagnosis of primary disease known before surgery, primary disease of non-GI or unknown origin and operation at university hospital all had favorable prognostic impact for overall survival.
  • CONCLUSIONS: Detection of non-genital ovarian metastasis at gynecologic surgery is associated with poor prognosis, and prognosis is worse in tumors with GI origin and if the primary is not detected prior to surgery.
  • The results indicate that a thorough patient evaluation is very important before surgery for suspected ovarian neoplasm.
  • [MeSH-major] Ovarian Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adolescent. Adult. Age Factors. Aged. Aged, 80 and over. Diagnosis, Differential. Female. Humans. Incidence. Middle Aged. Proportional Hazards Models. Registries. Survival Rate. Sweden / epidemiology

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  • [ErratumIn] Gynecol Oncol. 2007 Jul;106(1):276
  • (PMID = 17184826.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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76. Robinson-Smith TM, Isaacsohn I, Mercer CA, Zhou M, Van Rooijen N, Husseinzadeh N, McFarland-Mancini MM, Drew AF: Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice. Cancer Res; 2007 Jun 15;67(12):5708-16
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  • [Title] Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice.
  • The tumor microenvironment is known to have a profound effect on tumor progression in a highly context-specific manner.
  • We have investigated whether peritoneal inflammation plays a causative role in ovarian tumor metastasis, a poorly understood process.
  • Implantation of human ovarian tumor cells into the ovaries of severe combined immunodeficient mice resulted in peritoneal inflammation that corresponds temporally with tumor cell dissemination from the ovaries.
  • Suppression of inflammation with acetyl salicylic acid delayed ascites development and reduced tumor implant formation.
  • A similar prometastatic effect for inflammation was observed when tumor cells were injected directly into the peritoneum of severe combined immunodeficient mice, and in a syngeneic immunocompetent mouse model.
  • Inflammation-modulating treatments did not affect primary tumor development or in vitro tumor cell growth.
  • Depletion of peritoneal macrophages, but not neutrophils or natural killer cells, reduced tumor progression, as assessed by ascites formation and peritoneal metastasis.
  • We conclude that inflammation facilitates ovarian tumor metastasis by a mechanism largely mediated by macrophages, and which may involve stromal vascular endothelial growth factor production.
  • The confirmation of these findings in immunocompetent mice suggests relevance to human disease.
  • Identifying the mechanisms by which macrophages contribute to tumor metastasis may facilitate the development of new therapies specifically targeting immune cell products in the tumor microenvironment.
  • [MeSH-major] Inflammation / pathology. Macrophages / immunology. Neoplasm Metastasis / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Animals. Anti-Inflammatory Agents / pharmacology. Cell Line, Tumor. Disease Progression. Enzyme-Linked Immunosorbent Assay. Female. Humans. Mice. Mice, SCID. Neoplasm Transplantation. Reverse Transcriptase Polymerase Chain Reaction. Vascular Endothelial Growth Factor A / metabolism

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  • (PMID = 17575137.001).
  • [ISSN] 0008-5472
  • [Journal-full-title] Cancer research
  • [ISO-abbreviation] Cancer Res.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Vascular Endothelial Growth Factor A
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77. Ho L, Quan V, Henderson R: Bilateral ovarian metastases from breast carcinoma on FDG PET-CT. Clin Nucl Med; 2007 Dec;32(12):935-6
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  • [Title] Bilateral ovarian metastases from breast carcinoma on FDG PET-CT.
  • We report the PET-CT appearance of bilateral ovarian metastases in a 51-year-old woman with a history of right breast carcinoma with osseous metastasis diagnosed 14 years earlier.
  • The colon and stomach are the most common primary tumor sites in ovarian metastasis, followed by the breast, lung, and contralateral ovary.
  • It is important to consider this form of neoplasm in the differential diagnosis because the treatment and prognosis will be different from a dyssynchronous primary tumor.
  • [MeSH-major] Breast Neoplasms / pathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Bone Neoplasms / secondary. Diagnosis, Differential. Female. Humans. Middle Aged. Neoplasm Staging. Neoplasms, Second Primary / pathology. Positron-Emission Tomography. Time Factors. Tomography, X-Ray Computed

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  • (PMID = 18030045.001).
  • [ISSN] 0363-9762
  • [Journal-full-title] Clinical nuclear medicine
  • [ISO-abbreviation] Clin Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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78. Kim DD, Park IJ, Kim HC, Yu CS, Kim JC: Ovarian metastases from colorectal cancer: a clinicopathological analysis of 103 patients. Colorectal Dis; 2009 Jan;11(1):32-8
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  • [Title] Ovarian metastases from colorectal cancer: a clinicopathological analysis of 103 patients.
  • OBJECTIVE: To improve management of ovarian metastasis through assessment of clinicopathological features and treatment outcomes associated with ovarian metastasis from colorectal cancer.
  • METHOD: We recruited 103 subjects who were diagnosed with ovarian metastasis and subjected to surgery between June 1989 and December 2005.
  • Survival and its associated factors were analysed with a median follow-up of 31 months after ovarian surgery (range 1-129 months).
  • RESULTS: The mean age at diagnosis was 46 years (range 14-72 years), synchronous ovarian metastasis occurred in 74 patients and metachronous in 29 patients.
  • The primary tumour was more commonly associated with the colon rather than the rectum (84/1608, 5.2%vs 19/1534, 1.2%, P < 0.001).
  • The estimated 5-year disease free survival and overall survival rate were 40.1% and 26.6%, respectively.
  • From univariate analysis, lymphovascular invasion (35.6%vs 12.8%, P = 0.034), combined metastasis (50.9%vs 15.6%, P = 0.0035) and bilaterale ovarian metastasis (36.4%vs 10.6%, P = 0.015) were identified as significant poor prognosis factors, and from multivariate analysis combined metastasis and bilaterale ovarian metastasis were significant (P = 0.034 and P = 0.015, respectively).
  • CONCLUSION: This study suggests a role for regular follow-up computed tomography scans within 6 months postoperatively and tumour marker assays for the early detection of ovarian metastasis in premenopausal women after primary surgery, especially in colonic patients with poor prognostic factors.
  • [MeSH-major] Colorectal Neoplasms / pathology. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary

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  • (PMID = 18462217.001).
  • [ISSN] 1463-1318
  • [Journal-full-title] Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
  • [ISO-abbreviation] Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / CA-125 Antigen
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79. Iyibozkurt AC, Akhan SE, Topuz S, Citil I, Berkman S: Laparoscopic evaluation of metastatic ovarian cancer: a case report. Eur J Gynaecol Oncol; 2005;26(1):123-4
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  • [Title] Laparoscopic evaluation of metastatic ovarian cancer: a case report.
  • OBJECTIVE AND CASE: Both noninvasive and invasive methods have limited value in the diagnosis of metastatic ovarian cancer.
  • We present a case with the initial complaint of abdominal distention in whom primary and metastatic tumor sites were safely diagnosed by using laparoscopy: a gastric tumor with ovarian metastasis.
  • DISCUSSION: Diagnostic laparoscopy by the open technique provides a safe and effective diagnostic option in patients with metastatic ovarian cancer.
  • [MeSH-major] Carcinoma, Signet Ring Cell / diagnosis. Ovarian Neoplasms / diagnosis. Stomach Neoplasms / diagnosis
  • [MeSH-minor] Adult. Diagnosis, Differential. Female. Humans. Laparotomy. Magnetic Resonance Imaging. Neoplasm Metastasis


80. Souza FF, Katkar A, den Abbeele AD, Dipiro PJ: Breast angiosarcoma metastatic to the ovary. Case Rep Med; 2009;2009:381015
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  • [Title] Breast angiosarcoma metastatic to the ovary.
  • Ovarian masses are common findings in general gynecological practice.
  • Approximately 5%-10% of ovarian malignancies are diagnosed as metastatic tumors.
  • Primary angiosarcoma can arise anywhere in the body and when it arises in the breast, it usually affects women in their 3rd and 4th decades and accounts for one in 1700-2300 cases of primary breast cancer.
  • We present a case of a solitary ovarian metastasis from angiosarcoma of the breast.

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  • (PMID = 19718246.001).
  • [ISSN] 1687-9627
  • [Journal-full-title] Case reports in medicine
  • [ISO-abbreviation] Case Rep Med
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Other-IDs] NLM/ PMC2729273
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81. Jin Q, Kong B, Yang X, Cui B, Wei Y, Yang Q: Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer. In Vivo; 2007 Jul-Aug;21(4):593-8
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  • [Title] Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
  • BACKGROUND: Calcineurin B homologous protein isoform 2 (CHP2) was identified to be expressed in various malignant cell lines including ovarian cancer, but not in the normal tissue counterpart.
  • The biological function of CHP2 related to cancer progression is still unknown.
  • MATERIALS AND METHODS: A CHP2-negative human epithelial ovarian cancer cell line OVCAR3 was used for this study.
  • Cell proliferation, adhesion, motility, and invasion capacities were assessed in parental and transfected OVCAR3/CHP2 cell lines to explore the possible functions of CHP2 in ovarian cancer progression.
  • RESULTS: With RT-PCR analysis, CHP2-transfected OVCAR3/CHP2 cancer cells showed high CHP2 gene expression, whereas non-transfected clones did not produce detectable CHP2 mRNA.
  • CHP2-transfected OVCAR3/CHP2 cells showed increased proliferation rates and exhibited increased activities of cell adhesion, migration and invasion.
  • The current study provides the first evidence that overexpression of the CHP2 gene affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression, suggesting that CHP2 may be an attractive target for biological anticancer therapy.
  • [MeSH-major] Calcium-Binding Proteins / genetics. Calcium-Binding Proteins / metabolism. Gene Expression Regulation, Neoplastic. Ovarian Neoplasms / physiopathology. Ovarian Neoplasms / secondary
  • [MeSH-minor] Cation Transport Proteins / genetics. Cation Transport Proteins / metabolism. Cell Adhesion / physiology. Cell Division / physiology. Cell Line, Tumor. Cell Movement / physiology. Female. Humans. Neoplasm Invasiveness. Sodium-Hydrogen Antiporter / genetics. Sodium-Hydrogen Antiporter / metabolism. Transfection

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  • (PMID = 17708351.001).
  • [ISSN] 0258-851X
  • [Journal-full-title] In vivo (Athens, Greece)
  • [ISO-abbreviation] In Vivo
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / CHP1 protein, human; 0 / Calcium-Binding Proteins; 0 / Cation Transport Proteins; 0 / SLC9A1 protein, human; 0 / Sodium-Hydrogen Antiporter
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82. Urbański J, Mucha-Małecka A, Gliński B: [Cerebellar metastasis from ovarian carcinoma. A case report]. Ginekol Pol; 2005 Jun;76(6):481-3
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  • [Title] [Cerebellar metastasis from ovarian carcinoma. A case report].
  • This report presents an unusual case of 40-year-old woman with complete locoregional remission of ovarian carcinoma, presented with a single cerebellar metastasis.
  • [MeSH-major] Cerebellar Neoplasms / secondary. Cerebellar Neoplasms / therapy. Cystadenocarcinoma / secondary. Cystadenocarcinoma / therapy. Ovarian Neoplasms / pathology

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  • (PMID = 16149267.001).
  • [ISSN] 0017-0011
  • [Journal-full-title] Ginekologia polska
  • [ISO-abbreviation] Ginekol. Pol.
  • [Language] pol
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Poland
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83. Ayhan A, Gultekin M, Sağlam EA, Dursun P, Dogan NU, Aksan G, Usubutun A, Yuce K: Depth of invasion for appendiceal metastasis of ovarian cancers: does it have any clinical significance? J Obstet Gynaecol Res; 2008 Aug;34(4):557-60
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  • [Title] Depth of invasion for appendiceal metastasis of ovarian cancers: does it have any clinical significance?
  • AIM: Depth of appendiceal metastasis in patients with epithelial ovarian carcinoma (EOC) has not been previously analyzed for a possible relationship with clinico-pathological variables.
  • All of the patients had appendiceal metastasis.
  • RESULTS: Thirty-nine patients had serosal appendiceal metastasis (56.5%), while the remaining 30 patients (43.5%) had appendiceal metastasis extending toward the muscular layer (seromucosal metastasis: 16 within muscularis mucosa, 14 within the mucosa of the appendix).
  • The mean age at the time of diagnosis was 54.58 years (range, 26-88 years), with no significant difference between the groups (P = 0.9).
  • Three-year survival rates were 23.3% in the serosal metastasis and 27.9% in the seromucosal metastasis group (P = 0.9).
  • This figure was 25% for patients with only muscular metastasis and 41.6% for patients with appendiceal metastasis extending to the mucosal layer (P = 0.2).
  • CONCLUSION: This is the first report to analyze the metastatic pattern of EOC on the appendix with respect to depth of invasion which could not reveal a significant difference.
  • [MeSH-major] Appendiceal Neoplasms / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 18937709.001).
  • [ISSN] 1341-8076
  • [Journal-full-title] The journal of obstetrics and gynaecology research
  • [ISO-abbreviation] J. Obstet. Gynaecol. Res.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Japan
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84. Chung TS, Chang HJ, Jung KH, Park SY, Lim SB, Choi HS, Jeong SY: Role of surgery in the treatment of ovarian metastases from colorectal cancer. J Surg Oncol; 2009 Dec 1;100(7):570-4
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  • [Title] Role of surgery in the treatment of ovarian metastases from colorectal cancer.
  • BACKGROUND AND OBJECTIVES: The role of surgical resection in the treatment of metastatic ovarian tumors originating from colorectal cancer (CRC) remains uncertain.
  • METHODS: We analyzed the clinicopathological and follow-up data on 34 patients who underwent surgical resection of metastatic ovarian tumors originating from CRC.
  • RESULTS: Synchronous ovarian metastasis was detected in 27 patients (79.4%) and metachronous metastasis in 7 (20.6%).
  • The histologic type of the primary CRC was adenocarcinoma in 26 patients (76.5%), mucinous carcinoma in 7 (20.6%), and signet ring cell carcinoma in 1 (2.9%).
  • Cox's proportional hazards analysis showed that unilateral ovarian metastasis (relative risk [RR], 0.405; 95% confidence interval [CI], 0.171-0.959) and metastasis confined to the pelvic cavity (RR, 0.165; 95% CI, 0.031-0.878) were significantly associated with favorable prognosis.
  • CONCLUSIONS: Surgical resection may be beneficial in selected patients with ovarian metastasis arising from CRC, when metastasis is limited to the pelvis.
  • [MeSH-major] Colorectal Neoplasms / pathology. Ovarian Neoplasms / mortality. Ovarian Neoplasms / surgery
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adenocarcinoma, Mucinous / pathology. Adenocarcinoma, Mucinous / secondary. Adenocarcinoma, Mucinous / surgery. Adult. Aged. Aged, 80 and over. Carcinoma, Signet Ring Cell / pathology. Carcinoma, Signet Ring Cell / secondary. Carcinoma, Signet Ring Cell / surgery. Chemotherapy, Adjuvant. Female. Humans. Hysterectomy. Middle Aged. Ovariectomy. Peritoneal Neoplasms / mortality. Peritoneal Neoplasms / secondary. Peritoneal Neoplasms / surgery. Proportional Hazards Models. Retrospective Studies. Survival Rate


85. Ben Brahim E, Chatti S, Ayachi M, Zidi Y, Belhaj Salah M, Ben Othman M, Zouaoui T, Sassi S: [Krukenberg tumor: a clinico-pathological study of 5 cases]. Tunis Med; 2007 Sep;85(9):806-10
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  • [Title] [Krukenberg tumor: a clinico-pathological study of 5 cases].
  • [Transliterated title] Tumeur de Krukenberg: etude anatomo-clinique de cinq cas.
  • BACKGROUND: Krunkenberg tumor is defined as the ovarian metastases of a primary digestive tumor composed of a signet ring cells.
  • AIM: Describe the different characteristics of Krukenberg's tumor to improve diagnostic criteria and the therapeutic approche.
  • METHODS: Five cases of Krukenberg tumor are diagnosed in 5 year period between 2002 and 2005.
  • Most ovarian tumors were diagnosed synchronously (3 cases).
  • It was a gastric carcinoma in 3 cases and a colonic carcinoma in 2 patients.
  • Histological diagnosis wass easy.
  • We found in 2 cases a metastasis of colonic mucinous adenocarcinoma with signet ring-cell, in 2 other cases it was a gastric adenocarcinoma with exclusively signet ring cell and in the later case it was a gastric moderately differentiated adenocarcinoma with signet ring cell component.
  • The only hope for improved prognosis is to search for ovarian metastasis in all cases of digestive tumor.
  • [MeSH-major] Krukenberg Tumor / pathology. Ovarian Neoplasms / pathology

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  • (PMID = 18254316.001).
  • [ISSN] 0041-4131
  • [Journal-full-title] La Tunisie médicale
  • [ISO-abbreviation] Tunis Med
  • [Language] fre
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Tunisia
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86. Koyama T, Mikami Y, Saga T, Tamai K, Togashi K: Secondary ovarian tumors: spectrum of CT and MR features with pathologic correlation. Abdom Imaging; 2007 Nov;32(6):784-95
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  • [Title] Secondary ovarian tumors: spectrum of CT and MR features with pathologic correlation.
  • The ovaries represent common sites for metastatic disease.
  • The common primary sites for metastatic disease to the ovaries include the colon, stomach, breast, and the genitourinary tract.
  • Ovarian metastasis may occasionally represent the initial manifestation of disease, especially in cancers of the gastrointestinal tract.
  • The accurate diagnosis of this condition is always crucial since the misinterpretation of such tumors may cause significant adverse consequences for patients.
  • CT and MR features of secondary ovarian tumors differ according to the origins of the primary malignancies.
  • The great majority of metastases from gastric cancer are Krukenberg tumors, which are typically bilateral and characterized by lobulated solid tumors.
  • Metastases from colon cancer are usually cystic tumors with solid components of variable size.
  • Metastases from appendiceal tumor may present as ruptured mucinous ovarian tumors associated with pseudomyxoma peritonei.
  • Metastatic tumors from breast cancer are characterized by the relatively small size of the lesion.
  • Ovarian involvement by hematologic malignancies is typically bilateral, homogeneous solid masses.
  • Recognition of radiologic features of a variety of secondary ovarian tumors is beneficial for suspecting the secondary tumors under certain clinical conditions, and thus determining the appropriate management of the patients.
  • [MeSH-major] Magnetic Resonance Imaging / methods. Ovarian Neoplasms / diagnosis. Ovarian Neoplasms / secondary. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Diagnosis, Differential. Female. Humans

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  • (PMID = 17318680.001).
  • [ISSN] 1432-0509
  • [Journal-full-title] Abdominal imaging
  • [ISO-abbreviation] Abdom Imaging
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
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87. Alois M, Valentina P, Andreas G: The "Krukrnberg" tumor in male. Arch Esp Urol; 2005 Nov;58(9):971-3
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  • [Title] The "Krukrnberg" tumor in male.
  • OBJECTIVES: The ovarian metastasis by a gastrointestinal cancer is called Krukenberg tumor.
  • We report a case of metastasis to the testis and epididymis by gastric cancer that can be the analogue in male.
  • METHODS: A patient, submitted to total gastrectomy for a poorly differentiated gastric adenocarcinoma (TNM stage: pT3 GIII N+ M 1) developed one year later a painful swelling of the right hemiscrotum and groin.
  • The palpation revealed a painful mandarine-like mass conglobated in the right testis and epididymis, with a further mass at the external inguinal-ring and multiple little nodes along the spermatic cord.
  • An inguinal orchifuniculectomy was performed and the histological tests described a poorly differentiated, microtubular adenocarcinoma, infiltrating the connective tissue, without spreading to the testis, that was properly structured.
  • The atypical tumor formations expressed carcinoembryonal antigen, but were negative for -HCG and PSA.
  • The immune-histochemical results confirmed the diagnosis of an adenocarcinoma.
  • RESULTS/CONCLUSION: The metastasis in testicles and/or epididymus are rare and cannot be differentiated clinically or by imaging procedures from a primary testicle neoplasia.
  • Only the exact anamnesis of previous tumors and the age can provide some indications.
  • [MeSH-major] Adenocarcinoma / secondary. Epididymis. Genital Neoplasms, Male / secondary. Stomach Neoplasms / pathology. Testicular Neoplasms / secondary


88. Choi JY, Kim JI, Choi YC, Jun SY: [Two cases of histopathologically advanced (stage IV) early gastric cancer]. Korean J Gastroenterol; 2005 Jan;45(1):64-7
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  • [Title] [Two cases of histopathologically advanced (stage IV) early gastric cancer].
  • Various minimally invasive surgical techniques in some cases of early gastric cancer are becoming common practice.
  • However, there are rare cases of advanced cancer with distant metastasis although the invasion of the gastric wall is limited to the mucosa and/or submucosa (defined as early gastric cancer according to UICC-TNM classification).
  • We report two cases of early gastric cancer with distant metastasis (stage IV).
  • Both tumors were defined as early cancer because they were confined to the submucosa.
  • One was a type IIa early cancer, histologically classifiable as a signet ring cell carcinoma (according to the Japanese Classification of Gastric Carcinoma and UICC-TNM classification); the other was a surface spreading type IIb + IIc, classifiable as a signet ring cell carcinoma, too.
  • Stage IV factors were ovarian metastasis (Krukenberg tumor) in the former and N3 in the latter case.
  • [MeSH-major] Carcinoma, Signet Ring Cell / pathology. Stomach Neoplasms / pathology

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  • (PMID = 15665570.001).
  • [ISSN] 1598-9992
  • [Journal-full-title] The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • [ISO-abbreviation] Korean J Gastroenterol
  • [Language] kor
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Korea (South)
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89. El-Ghobashy A, Ohadike C, Wilkinson N, Lane G, Campbell JD: Recurrent urachal mucinous adenocarcinoma presenting as bilateral ovarian tumors on cesarean delivery. Int J Gynecol Cancer; 2009 Dec;19(9):1539-41
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  • [Title] Recurrent urachal mucinous adenocarcinoma presenting as bilateral ovarian tumors on cesarean delivery.
  • Secondary ovarian cancers, Krukenberg tumors, are a distinctive subset of metastatic tumors arising from the gastrointestinal tract (stomach, colon, and appendix), the biliary system, the breast, or other genital organs.
  • These tumors account for 5% of all ovarian malignancies.
  • Such metastases could mimic primary mucinous ovarian adenocarcinomas.
  • Primary adenocarcinoma of the bladder accounts for less than 1% of all bladder malignancies; one third of these tumors are urachal in origin.
  • These tumors have a predilection to locally spread to the surrounding organs.
  • Ovarian metastasis is a rare event and is infrequently reported in literature.
  • [MeSH-major] Abdominal Neoplasms / diagnosis. Adenocarcinoma, Mucinous / diagnosis. Cesarean Section. Ovarian Neoplasms / diagnosis. Pregnancy Complications, Neoplastic / diagnosis. Urachus
  • [MeSH-minor] Adult. Delivery, Obstetric. Diagnosis, Differential. Female. Humans. Pregnancy


90. Tiwari A, Kumar N, Bajpai R, Lal P: Bone metastasis from ovarian cancer. J Cancer Res Ther; 2007 Jan-Mar;3(1):34-6
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  • [Title] Bone metastasis from ovarian cancer.
  • We report a case of epithelial ovarian cancer, which presented with lumbar vertebral metastasis soon after treatment, as a part of distant spread.
  • [MeSH-major] Cystadenocarcinoma, Mucinous / secondary. Liver Neoplasms / secondary. Lumbar Vertebrae. Ovarian Neoplasms / pathology. Spinal Neoplasms / secondary


91. de Waal YR, Thomas CM, Oei AL, Sweep FC, Massuger LF: Secondary ovarian malignancies: frequency, origin, and characteristics. Int J Gynecol Cancer; 2009 Oct;19(7):1160-5
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  • [Title] Secondary ovarian malignancies: frequency, origin, and characteristics.
  • OBJECTIVE: To evaluate the frequency of metastatic tumors among malignant ovarian neoplasms, the site distribution of the primary malignancies that give rise to ovarian metastasis and the clinicopathologic features of metastatic tumors.
  • METHODS: We analyzed a total number of 116 patients diagnosed with metastasis to the ovary between 1985 and 2007 at the Radboud University Nijmegen Medical Centre.
  • The medical records of the patients were reviewed for age at diagnosis, medical history, menopausal state, clinical manifestation, primary tumor, intraoperative findings, and prognosis.
  • RESULTS: Metastasis to the ovary accounted for 15% of all ovarian malignancies identified in the 22-year period at the Radboud University Nijmegen Medical Centre.
  • There were 22 metastases to the ovary that mimicked a primary ovarian tumor at first clinical presentation, of which the single greatest number of cases (36%) originated from a primary tumor of the large intestine.
  • Ovarian cysts were present in 71% of patients, and most ovaries with metastatic disease were 10 cm in diameter or less.
  • Bilateral ovarian involvement was present in 69% of the patients, including all patients with tumors of the stomach.
  • CONCLUSION: In case of an ovarian tumor, metastatic disease should always be considered to avoid pitfalls in diagnosis and therapy.
  • The gastrointestinal tract is the most likely location of the primary tumor, followed by breast and endometrium.
  • [MeSH-major] Carcinoma / secondary. Ovarian Neoplasms / secondary

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  • (PMID = 19823050.001).
  • [ISSN] 1525-1438
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 17
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92. Knösel T, Schlüns K, Dietel M, Petersen I: Chromosomal alterations in lung metastases of colorectal carcinomas: associations with tissue specific tumor dissemination. Clin Exp Metastasis; 2005;22(7):533-8
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  • [Title] Chromosomal alterations in lung metastases of colorectal carcinomas: associations with tissue specific tumor dissemination.
  • Comparative genomic hybridization was used to screen colorectal carcinomas for chromosomal aberrations that are associated with the metastatic phenotype of the lung.
  • Specimens of 13 lung metastases, 6 primary tumors, 1 lymph node metastasis, 1 liver metastasis, and 1 ovarian metastasis were investigated and added to our CGH colon cancer tumor collective, comprising 85 tumor specimens from 56 patients (see CGH online tumor database at http://amba.charite.de/cgh).
  • Comparing lung metastases with their corresponding primary tumors, particularly more deletions at 3p, 8p, 12q, 17q, and 21q21 and gains at 5p were observed.
  • Based on our results, we wish to suggest a metastatic progression model.
  • Specific subpopulations of metastatic cells have a distinct metastatic potential, which is reflected by a non-random accumulation of chromosomal alterations.
  • Distinct alterations already exist within the primary tumor and this "ready to go package" gives the cells the metastatic potential to achieve the complex series of events needed for metastasis.
  • [MeSH-major] Chromosome Aberrations. Colorectal Neoplasms / genetics. Colorectal Neoplasms / pathology. Lung Neoplasms / genetics. Lung Neoplasms / secondary. Neoplasm Metastasis / genetics
  • [MeSH-minor] Chromosome Deletion. Chromosome Mapping. Chromosomes, Human. Humans. Liver Neoplasms / genetics. Liver Neoplasms / secondary. Lymphatic Metastasis. Nucleic Acid Hybridization

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  • (PMID = 16475023.001).
  • [ISSN] 0262-0898
  • [Journal-full-title] Clinical & experimental metastasis
  • [ISO-abbreviation] Clin. Exp. Metastasis
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Netherlands
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93. Rafii A, Ferron G, Lacroix-Triki M, Dalenc F, Gladieff L, Querleu D: Abdominal wall metastasis of ovarian carcinoma after low transverse abdominal incision: report of two cases and review of literature. Int J Gynecol Cancer; 2006 Jan-Feb;16 Suppl 1:334-7
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  • [Title] Abdominal wall metastasis of ovarian carcinoma after low transverse abdominal incision: report of two cases and review of literature.
  • Occurrence of parietal metastases after surgery for a suspect adnexal mass may worsen the prognosis of the disease.
  • However, it is not clear whether abdominal wall metastases is related to specific biologic features or simply to surgical mismanagement involving small incisions and traumatic extraction of the specimen, resulting in direct seeding of cancer cells.
  • We report two cases with development of parietal dissemination of ovarian carcinomas after Pfannenstiel incision.
  • Pfannenstiel incisions for exploration of suspicious adnexal masses increase the risk of extensive parietal metastasis in case of malignancy because they require reflection of several sheaths of tissue.
  • The parietal extension of the disease may need major parietal resection that can worsen the functional and general outcome of the patients.
  • [MeSH-major] Adenocarcinoma, Mucinous / secondary. Granulosa Cell Tumor / secondary. Neoplasm Seeding. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary
  • [MeSH-minor] Abdominal Wall. Adult. Antineoplastic Combined Chemotherapy Protocols / administration & dosage. Bleomycin / administration & dosage. Cisplatin / administration & dosage. Doxorubicin / administration & dosage. Etoposide / administration & dosage. Female. Gynecologic Surgical Procedures. Humans. Ifosfamide / administration & dosage. Middle Aged. Neoplasm Recurrence, Local / drug therapy. Neoplasm Recurrence, Local / surgery. Paclitaxel / administration & dosage

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  • (PMID = 16515617.001).
  • [ISSN] 1048-891X
  • [Journal-full-title] International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
  • [ISO-abbreviation] Int. J. Gynecol. Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 11056-06-7 / Bleomycin; 6PLQ3CP4P3 / Etoposide; 80168379AG / Doxorubicin; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide; BEP protocol
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94. Tan KL, Tan WS, Lim JF, Eu KW: Krukenberg tumors of colorectal origin: a dismal outcome--experience of a tertiary center. Int J Colorectal Dis; 2010 Feb;25(2):233-8
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  • [Title] Krukenberg tumors of colorectal origin: a dismal outcome--experience of a tertiary center.
  • BACKGROUND: Krukenberg tumor (KT) is described as metastases of the ovary usually from a tumor of gastric origin.
  • As colorectal cancer (CRC) is now the most common cancer in Singapore, we are seeing more KT with colorectal origin.
  • PURPOSE: To determine the pattern of presentation of KT from CRC origin in terms of patient demographics, time of onset related to the diagnosis of CRC, presence of elevated serum tumor markers, carcinomatosis peritoneii, and survival of patients.
  • Median age at diagnosis was 53 years old (range: 38-79).
  • Sixteen patients (64%) had ovarian metastasis at the time of diagnosis of the CRC.
  • Eleven patients (44%) had unilateral ovarian involvement.
  • Serum Carcinoembryonic antigen (CEA) was available for 21 patients, 18 (86%) were raised; serum cancer antigen-125 (CA-125) was available for seven patients, five (71%) were raised.
  • There were 11 mortalities (44%) and all died of the disease.
  • Median time between diagnosis of KT and death was 19 months.
  • The rest of the patients were alive with existence of disease at last follow-up.
  • There was 0% disease-free survival.
  • Patients investigated for elevated CA-125 and unilateral ovarian mass should have the diagnosis of colorectal cancer excluded before treatment of ovarian mass.
  • [MeSH-major] Adenocarcinoma / secondary. Colorectal Neoplasms / pathology. Krukenberg Tumor / secondary. Ovarian Neoplasms / secondary
  • [MeSH-minor] Adult. Age of Onset. Aged. CA-125 Antigen / blood. Carcinoembryonic Antigen / blood. Disease-Free Survival. Female. Humans. Middle Aged. Peritoneal Neoplasms / secondary. Retrospective Studies. Singapore / epidemiology. Survival Analysis. Time Factors. Treatment Outcome

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  • (PMID = 19705132.001).
  • [ISSN] 1432-1262
  • [Journal-full-title] International journal of colorectal disease
  • [ISO-abbreviation] Int J Colorectal Dis
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / CA-125 Antigen; 0 / Carcinoembryonic Antigen
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95. Giannakopoulos ChK, Kyriakidou GK, Toufexi GE: Palmar fasciitis and polyarthritis associated with secondary ovarian carcinoma. Case report. Eur J Gynaecol Oncol; 2005;26(3):339-41
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  • [Title] Palmar fasciitis and polyarthritis associated with secondary ovarian carcinoma. Case report.
  • Palmar fasciitis and a polyarthritis syndrome (PFPAS) is an uncommon paraneoplastic syndrome often associated with occult neoplasms, including ovarian and pancreatic carcinomas.
  • Twelve months after onset of the symptoms an ovarian and pancreatic adenocarcinoma was diagnosed synchronously.
  • The spread pattern and other features of the neoplasm indicate that it was a primary pancreatic cancer with ovarian metastasis.
  • Surgical excision of tumor and adjuvant chemotherapy caused remission of symptoms.
  • A literature review of PFPAS and secondary ovarian neoplasms with a pancreatic primary tumor is discussed.
  • [MeSH-major] Adenocarcinoma / secondary. Arthritis / etiology. Fasciitis / etiology. Ovarian Neoplasms / secondary. Pancreatic Neoplasms / pathology

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  • (PMID = 15991542.001).
  • [ISSN] 0392-2936
  • [Journal-full-title] European journal of gynaecological oncology
  • [ISO-abbreviation] Eur. J. Gynaecol. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 8N3DW7272P / Cyclophosphamide; BG3F62OND5 / Carboplatin
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96. Yu L, Li X, Yang W: Pulmonary blastoma metastatic to the ovary. Int J Gynecol Pathol; 2009 Jan;28(1):59-62
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  • [Title] Pulmonary blastoma metastatic to the ovary.
  • A 38-year-old woman was diagnosed as biphasic PB (1 subgroup of sarcomatoid carcinoma) and treated by surgery, radiotherapy, and chemotherapy.
  • Six months later, the patient presented with menstrual disorder and a mass in the abdominal-pelvic cavity.
  • Abdominal hysterectomy and bilateral salpingo-oophorectomy showed the morphology of metastatic PB in both ovaries.
  • The metastatic tumor was composed exclusively of epithelial components resembling well-differentiated fetal adenocarcinoma.
  • To our knowledge, this is the first reported case of bilateral ovarian metastasis from biphasic PB.
  • [MeSH-major] Lung Neoplasms / pathology. Ovarian Neoplasms / secondary. Pulmonary Blastoma / secondary

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  • [CommentIn] Int J Gynecol Pathol. 2010 Jul;29(4):339-40 [20567146.001]
  • (PMID = 19047906.001).
  • [ISSN] 1538-7151
  • [Journal-full-title] International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
  • [ISO-abbreviation] Int. J. Gynecol. Pathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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97. Yoshioka R, Okabayashi T, Nishimori I, Maeda N, Sugimoto T, Kohsaki T, Onishi S, Fukaya T, Kobayashi M, Hanazaki K: A long-survived case with solitary splenic metastasis from ovarian carcinoma. Surg Technol Int; 2008;17:192-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] A long-survived case with solitary splenic metastasis from ovarian carcinoma.
  • A61-year-old postmenopausal woman with ovarian carcinoma was treated with two surgical operations and a series of platinum-based chemotherapy.
  • A solitary metastasis into the splenic parenchyma was identified 33 months after the second surgery by abdominal computed tomography with an increased serum level of CA-125.
  • Solitary metastases from ovarian cancer into the splenic parenchyma are extremely rare.
  • Among 18 cases previously reported, this present case shows the longest disease-free survival.
  • [MeSH-major] Carcinoma, Transitional Cell / secondary. Carcinoma, Transitional Cell / surgery. Ovarian Neoplasms / surgery. Splenectomy / methods. Splenic Neoplasms / secondary. Splenic Neoplasms / surgery
  • [MeSH-minor] Disease-Free Survival. Female. Humans. Middle Aged. Treatment Outcome

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  • (PMID = 18802901.001).
  • [ISSN] 1090-3941
  • [Journal-full-title] Surgical technology international
  • [ISO-abbreviation] Surg Technol Int
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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98. Takeshima N, Hirai Y, Umayahara K, Fujiwara K, Takizawa K, Hasumi K: Lymph node metastasis in ovarian cancer: difference between serous and non-serous primary tumors. Gynecol Oncol; 2005 Nov;99(2):427-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymph node metastasis in ovarian cancer: difference between serous and non-serous primary tumors.
  • OBJECTIVE: To investigate the lymph node sites most susceptible to involvement relative to primary tumor histology in ovarian cancer.
  • METHODS: The locations of metastatic lymph nodes were investigated in 208 patients with primary ovarian cancer who underwent systemic lymphadenectomy covering both the pelvic and para-aortic regions.
  • RESULTS: Lymph node metastasis was present in 12.8% (20/156) of patients with stage I (pT1M0), 48.6% (18/37) with stage II (pT2M0), and 60% (9/15) with stage III (pT3M0) disease, thus in 22.6% (47/208) of all study patients.
  • Isolated para-aortic nodal involvement was present in 23.3% (14/60) of patients with serous tumor and 4.1% (6/148) of those with non-serous tumor (P = 0.00002).
  • In an analysis of 35 positive nodes from 25 patients with up to 3 positive nodes, 86.4% (19/22) of metastatic lymph nodes from patients with serous tumor were found in the para-aortic region, with 14 positive nodes located above the inferior mesenteric artery (IMA) and 5 below it, whereas metastasis to para-aortic lymph nodes accounted for 53.8% (7/13) of metastatic lymph nodes from patients with non-serous tumor (P = 0.0334).
  • CONCLUSIONS: The locations of metastatic lymph nodes in ovarian cancer depend upon the histologic type of the primary cancer.
  • In cases of serous tumor, the para-aortic region, particularly above the IMA, is the prime site for the earliest lymph node metastasis.
  • However, the likelihood of pelvic node involvement is almost equal to that of para-aortic node involvement in cases of non-serous tumor.
  • [MeSH-major] Adenocarcinoma, Clear Cell / pathology. Cystadenocarcinoma, Serous / pathology. Lymph Nodes / pathology. Ovarian Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Middle Aged. Neoplasm Staging

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  • (PMID = 16112718.001).
  • [ISSN] 0090-8258
  • [Journal-full-title] Gynecologic oncology
  • [ISO-abbreviation] Gynecol. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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99. Singh RP, Tullis S, Hatton M, Rubin PA: Orbital metastasis from ovarian carcinoma in a patient with BRCA-2 mutation. Ophthal Plast Reconstr Surg; 2006 Jul-Aug;22(4):298-9
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  • [Title] Orbital metastasis from ovarian carcinoma in a patient with BRCA-2 mutation.
  • A 45-year-old woman with BRCA-2 mutation-positive ovarian carcinoma had pain, swelling, and proptosis of her left eye.
  • Fine-needle aspiration and lateral orbitotomy were used to obtain tissue for diagnosis.
  • Pathology confirmed poorly differentiated tumor cells consistent with ovarian carcinoma.
  • [MeSH-major] Adenocarcinoma / secondary. Genes, BRCA2. Mutation / genetics. Orbital Neoplasms / secondary. Ovarian Neoplasms / genetics. Ovarian Neoplasms / pathology

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  • (PMID = 16855505.001).
  • [ISSN] 0740-9303
  • [Journal-full-title] Ophthalmic plastic and reconstructive surgery
  • [ISO-abbreviation] Ophthal Plast Reconstr Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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100. Inoue Y, Toiyama Y, Yokoe T, Tanaka K, Miki C, Kusunoki M: Direct evidence that heterogeneity necessitates and limits the use of multidrug chemotherapy in colon cancer. Mol Med Rep; 2008 Jul-Aug;1(4):531-5
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  • [Title] Direct evidence that heterogeneity necessitates and limits the use of multidrug chemotherapy in colon cancer.
  • Considerable progress in the form of multidrug chemotherapy has recently been made in chemotherapy for the prolongation of survival in advanced colon cancer.
  • It is generally accepted that colon cancer is biologically heterogeneous for multiple properties, including sensitivity to chemotherapeutic agents and metastasis.
  • Although this partly explains the success of multidrug chemotherapy, there has been no direct evidence that multidrug regimens affect individual heterogenous cancer characteristics in colon cancer.
  • Here, we present a case of metachronous ovarian metastasis in a colon cancer patient with dissemination who underwent irinotecan-based followed by oxaliplatin-based chemotherapy.
  • We were able to obtain three samples from the patient, one of primary cancer and two of metastatic tumors from secondary surgery.
  • Of note, both chemoresistant and chemosensitive tumors were present in the patient at the same time.
  • To understand the influence of multidrugs on individual cancer characteristics, we examined differences in the molecular characteristics of the three samples using RT-PCR, focusing in particular on alterations in chemoresistant genes.
  • In shrunken peritoneal metastasis, we found a significant increase in the mRNA levels of an irinotecan-sensitive gene, although other molecular factors were resistant to both 5-FU and oxaliplatin.
  • We also confirmed that the recurrent ovarian tumor showed significant resistance to all three drugs: 5-FU, irinotecan and oxaliplatin.
  • These results suggest that the heterogeneity of colon cancer necessitates and limits the use of multidrug chemotherapy.

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  • (PMID = 21479445.001).
  • [ISSN] 1791-2997
  • [Journal-full-title] Molecular medicine reports
  • [ISO-abbreviation] Mol Med Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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