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1. Chen X, Sievers E, Hou Y, Park R, Tohme M, Bart R, Bremner R, Bading JR, Conti PS: Integrin alpha v beta 3-targeted imaging of lung cancer. Neoplasia; 2005 Mar;7(3):271-9
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  • [Title] Integrin alpha v beta 3-targeted imaging of lung cancer.
  • A series of radiolabeled cyclic arginine-glycine-aspartic acid (RGD) peptide ligands for cell adhesion molecule integrin alpha v beta 3-targeted tumor angiogenesis targeting are being developed in our laboratory.
  • In this study, this effort continues by applying a positron emitter 64Cu-labeled PEGylated dimeric RGD peptide radiotracer 64Cu-DOTA-PEG-E[c(RGDyK)]2 for lung cancer imaging.
  • The minimum nonspecific activity accumulation in normal lung tissue and heart rendered high-quality orthotopic lung cancer tumor images, enabling clear demarcation of both the primary tumor at the upper lobe of the left lung, as well as metastases in the mediastinum, contralateral lung, and diaphragm.
  • As a comparison, fluorodeoxyglucose (FDG) scans on the same mice were only able to identify the primary tumor, with the metastatic lesions masked by intense cardiac uptake and high lung background.
  • 64Cu-DOTA-PEG-E[c(RGDyK)]2 is an excellent position emission tomography (PET) tracer for integrin-positive tumor imaging.
  • Further studies to improve the receptor binding affinity of the tracer and subsequently to increase the magnitude of tumor uptake without comprising the favorable in vivo kinetics are currently in progress.

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  • (PMID = 15799827.001).
  • [ISSN] 1522-8002
  • [Journal-full-title] Neoplasia (New York, N.Y.)
  • [ISO-abbreviation] Neoplasia
  • [Language] ENG
  • [Grant] United States / NIBIB NIH HHS / EB / R21 EB001785; United States / NCI NIH HHS / CA / P20 CA86532
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Integrin alphaVbeta3; 0 / Oligopeptides; 0 / Peptides; 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18; 30IQX730WE / Polyethylene Glycols; 789U1901C5 / Copper; 99896-85-2 / arginyl-glycyl-aspartic acid
  • [Other-IDs] NLM/ PMC1501139
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2. Martorell M, Ortiz CM, Garcia JA: Testicular fusocellular rhabdomyosarcoma as a metastasis of elbow sclerosing rhabdomyosarcoma: A clinicopathologic, immunohistochemical and molecular study of one case. Diagn Pathol; 2010;5:52
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  • [Title] Testicular fusocellular rhabdomyosarcoma as a metastasis of elbow sclerosing rhabdomyosarcoma: A clinicopathologic, immunohistochemical and molecular study of one case.
  • Histologically, the tumor showed an abundant extracellular hyaline matrix with extratumoral vascular emboli and microscopic foci of fusocellular embryonal rhabdomyosarcoma (FRMS) separated by a fibrotic band from the sclerosing areas.
  • One year later the patient presented with a right intratesticular tumor of 1.2 x 0.8 cm, which was reported as pure FRMS.
  • Both the elbow emboli with the extratumoral foci of FRMS and the intratesticular tumor were positive for Myogenin, MyoD1, Vimentin and Desmin.
  • Using fluorescent in situ hybridization (FISH), the SRMS and the FRMS tumor cells of the elbow and the FRMS tumor cells of the testis were found to be negative for FOXO1A translocation in chromosome 13.
  • Six months following testicular resection, the patient died of multiple metastases in the mediastinum, lung and right thigh.
  • [MeSH-major] Rhabdomyosarcoma, Embryonal / secondary. Soft Tissue Neoplasms / pathology. Testicular Neoplasms / secondary
  • [MeSH-minor] Adult. Biomarkers, Tumor / analysis. Biomarkers, Tumor / genetics. Chemotherapy, Adjuvant. Chromosomes, Human, Pair 13. Elbow. Fatal Outcome. Fibrosis. Forkhead Transcription Factors / genetics. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Orchiectomy. Sclerosis. Time Factors. Tomography, X-Ray Computed. Translocation, Genetic. Treatment Outcome. Whole Body Imaging

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  • (PMID = 20701800.001).
  • [ISSN] 1746-1596
  • [Journal-full-title] Diagnostic pathology
  • [ISO-abbreviation] Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; 0 / FOXO1 protein, human; 0 / Forkhead Transcription Factors
  • [Other-IDs] NLM/ PMC3224966
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3. Luo L, Wang H, Ma H, Zou H, Li D, Zhou Y: [TACE with Ar-He cryosurgery combined minimal invasive technique for the treatment of primary NSCLC in 139 cases]. Zhongguo Fei Ai Za Zhi; 2010 Jan;13(1):60-3
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  • BACKGROUND AND OBJECTIVE: TACE, Ar-He target cryosurgery and radioactive seeds implantation are the mainly micro-invasive methods in the treatment of lung cancer.
  • This article summarizes the survival quality after treatment, the clinical efficiency and survival period, and analyzes the advantages and shortcomings of each methods so as to evaluate the clinical effect of non-small cell lung cancer with multiple minimally invasive treatment.
  • METHODS: All the 139 cases were non-small cell lung cancer patients confirmed by pathology and with follow up from July 2006 to July 2009 retrospectively, and all of them lost operative chance by comprehensive evaluation.
  • Among the 139 cases, 102 cases of primary and 37 cases of metastasis to mediastinum, lung and chest wall, 71 cases of abundant blood supply used the combination of superselective target artery chemotherapy, Ar-He target cryoablation and radiochemotherapy with seeds implantation; 48 cases of poor blood supply use single Ar-He target cryoablation; 20 cases of poor blood supply use the combination of Ar-He target cryoablation and radiochemotheraoy with seeds implantation.
  • To non-small cell lung cancer, we can improve the middle and long term clinical effect by using the different combination of multiple minimally invasive treatments according to the patient's condition.

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  • (PMID = 20672706.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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4. Yagihashi Y, Okinami T, Fukuzawa S, Kuriki K: [Pericardial effusion due to metastatic prostate cancer: a case report]. Hinyokika Kiyo; 2008 May;54(5):369-72
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  • [Title] [Pericardial effusion due to metastatic prostate cancer: a case report].
  • Cytologic study suggested metastatic adenocarcinoma or malignant mesothelioma.
  • At autopsy, the major finding was poorly differentiated adenocarcinoma of the prostate with metastases to the mediastinum.
  • [MeSH-major] Adenocarcinoma / pathology. Mediastinal Neoplasms / secondary. Pericardial Effusion / etiology. Prostatic Neoplasms / pathology


5. Chen TM, Donington J, Mak G, Berry GJ, Ruoss SJ, Rosen GD, Upadhyay D: Recurrence of pulmonary intravascular bronchoalveolar tumor with mediastinal metastasis 20 years later. Respir Med; 2006 Feb;100(2):367-70
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  • [Title] Recurrence of pulmonary intravascular bronchoalveolar tumor with mediastinal metastasis 20 years later.
  • Pulmonary intravascular bronchoalveolar tumor (IVBAT) also recognized as pulmonary epithelioid hemangioendothelioma, is a rare malignant vascular tumor of unknown etiology.
  • IVBAT is a tumor of multicentric origin and the lungs are rarely involved, with only about 60 cases of pulmonary IVBAT described in the literature.
  • We report an unusual case of pulmonary IVBAT that recurred in the lung with metastasis to the mediastinum.
  • [MeSH-major] Hemangioendothelioma, Epithelioid / pathology. Lung Neoplasms / pathology. Mediastinal Neoplasms / secondary. Neoplasm Recurrence, Local

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  • (PMID = 15990286.001).
  • [ISSN] 0954-6111
  • [Journal-full-title] Respiratory medicine
  • [ISO-abbreviation] Respir Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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6. Fujino H, Kondo K, Ishikura H, Maki H, Kinoshita H, Miyoshi T, Takahashi Y, Sawada N, Takizawa H, Nagao T, Sakiyama S, Monden Y: Matrix metalloproteinase inhibitor MMI-166 inhibits lymphogenous metastasis in an orthotopically implanted model of lung cancer. Mol Cancer Ther; 2005 Sep;4(9):1409-16
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  • [Title] Matrix metalloproteinase inhibitor MMI-166 inhibits lymphogenous metastasis in an orthotopically implanted model of lung cancer.
  • Matrix metalloproteinases (MMP) are considered to be critically involved in tumor invasion and the metastasis of various cancers.
  • The purpose of this study was to evaluate the effects of MMI-166 on both the growth of the implanted tumor and the lymph node metastasis of the mediastinum and prolonging the life span, using an orthotopic implantation model of the Ma44-3 cancer cell line.
  • We examined the anti-invasive effect of MMI-166 in lung cancer cell lines using an in vitro invasion assay.
  • MMI-166 (200 mg/kg body weight) or a vehicle was administered orally to the orthotopically implanted lung cancer model.
  • MMI-166 dose-dependently inhibited the invasion of cancer cell lines with expressions of MMP-2 and/or MMP-9 in vitro.
  • In vivo, MMI-166 significantly inhibited mediastinal lymph node metastasis in this orthotopic model (weight of the mediastinum: control, 0.089 +/- 0.009 versus MMI-166, 0.069 +/- 0.008 mg; P = 0.005; metastatic area: control, 93,495 +/- 55,747 versus MMI-166, 22,747 +/- 17,478 pixels; P = 0.045).
  • These results showed that MMI-166 could possibly inhibit lymph node metastasis and prolong the life span in lung cancer patients.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / prevention & control. Carcinoma, Non-Small-Cell Lung / secondary. Disease Models, Animal. Lung Neoplasms / pathology. Matrix Metalloproteinase Inhibitors. Sulfonamides / pharmacology
  • [MeSH-minor] Animals. Humans. Injections, Subcutaneous. Lymphatic Metastasis. Male. Mice. Mice, SCID. Neoplasm Invasiveness. Neovascularization, Pathologic / prevention & control. Survival Rate. Tumor Cells, Cultured

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  • (PMID = 16170033.001).
  • [ISSN] 1535-7163
  • [Journal-full-title] Molecular cancer therapeutics
  • [ISO-abbreviation] Mol. Cancer Ther.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Matrix Metalloproteinase Inhibitors; 0 / N-alpha-(4-(2-phenyl-2H- tetrazole-5-yl) phenyl sulfonyl)-D-tryptophan; 0 / Sulfonamides
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7. Lokaj P, Krivan L: [SIADH as only paraneoplastic cause of the small cell lung cancer]. Vnitr Lek; 2008 Mar;54(3):273-5
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  • [Title] [SIADH as only paraneoplastic cause of the small cell lung cancer].
  • We searched for the cause of that syndrome and finally we found that the cause of that syndrome was small cell lung cancer with an expansion into the mediastinum and metastases into the skelet.
  • [MeSH-minor] Bone Neoplasms / secondary. Female. Humans. Middle Aged

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  • (PMID = 18522296.001).
  • [ISSN] 0042-773X
  • [Journal-full-title] Vnitr̆ní lékar̆ství
  • [ISO-abbreviation] Vnitr Lek
  • [Language] cze
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Czech Republic
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8. Lee WJ, Lee DW, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK: Cutaneous metastasis of extraskeletal osteosarcoma arising in the mediastinum. Am J Dermatopathol; 2008 Dec;30(6):629-31
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  • [Title] Cutaneous metastasis of extraskeletal osteosarcoma arising in the mediastinum.
  • Cutaneous metastases have been reported in 5%-10% of patients with internal malignancy.
  • The most frequent metastatic site of extraskeletal osteosarcoma (ESOS) is the lungs.
  • Cutaneous metastasis of ESOS is rare.
  • To our knowledge, only one case of ESOS has been reported with skin metastasis, histopathologically classified as the osteoblastic subtype.
  • Here, we describe a case of chondroblastic ESOS arising in the mediastinum with metastasis to the skin.
  • Our patient presented with a scalp nodule after diagnosis of primary ESOS at the mediastinum.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Osteosarcoma / diagnosis. Osteosarcoma / secondary. Skin Neoplasms / diagnosis. Skin Neoplasms / secondary

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  • (PMID = 19033945.001).
  • [ISSN] 1533-0311
  • [Journal-full-title] The American Journal of dermatopathology
  • [ISO-abbreviation] Am J Dermatopathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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9. Wei S, Carroll W, Lazenby A, Bell W, Lopez R, Said-Al-Naief N: Sinonasal teratocarcinosarcoma: report of a case with review of literature and treatment outcome. Ann Diagn Pathol; 2008 Dec;12(6):415-25
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  • Sinonasal teratocarcinosarcoma is a highly malignant, polymorphous neoplasm that combines features of carcinosarcoma and teratoma.
  • The patient underwent a complex procedure for a T3N0 tumor.
  • Postoperatively, the patient had a rapid local recurrence of the tumor and underwent reexcision, and was treated with radiotherapy and chemotherapy.
  • Twelve months after his primary resection, computerized tomography scans revealed an intrathoracic tumor with dominant mass in the left hilum and metastases to the mediastinum, left pleural space, and both lungs.
  • The high rate of local recurrence and metastasis is indicative of its highly aggressive biologic behavior.
  • Almost half of the patients died of tumor within 3 years of diagnosis, despite aggressive therapy.
  • [MeSH-major] Carcinosarcoma / diagnosis. Carcinosarcoma / therapy. Nose Neoplasms / diagnosis. Nose Neoplasms / therapy. Teratoma / diagnosis. Teratoma / therapy

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  • (PMID = 18995206.001).
  • [ISSN] 1532-8198
  • [Journal-full-title] Annals of diagnostic pathology
  • [ISO-abbreviation] Ann Diagn Pathol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 33
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10. Singh P, Camazine B, Jadhav Y, Gupta R, Mukhopadhyay P, Khan A, Reddy R, Zheng Q, Smith DD, Khode R, Bhatt B, Bhat S, Yaqub Y, Shah RS, Sharma A, Sikka P, Erickson RA: Endoscopic ultrasound as a first test for diagnosis and staging of lung cancer: a prospective study. Am J Respir Crit Care Med; 2007 Feb 15;175(4):345-54
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  • [Title] Endoscopic ultrasound as a first test for diagnosis and staging of lung cancer: a prospective study.
  • RATIONALE: Multiple tests are required for the management of lung cancer.
  • OBJECTIVES: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) was evaluated as a single test for the diagnosis and staging (thoracic and extrathoracic) of lung cancer.
  • RESULTS: Of 113 subjects with lung cancer, EUS was performed as a first test (after CT scan) for diagnosis in 93 (82%) of them.
  • EUS-FNA established tissue diagnosis in 70% of cases.
  • EUS-FNA, CT, and positron emission tomography detected metastases to the mediastinal lymph nodes with accuracies of 93, 81, and 83%, respectively.
  • EUS-FNA was significantly better than CT at detecting distant metastases (accuracies of 97 and 89%, respectively; p = 0.02).
  • Metastases to lymph nodes at the celiac axis (CLNs) were observed in 11% of cases.
  • The diagnostic yields of EUS-FNA and CT for detection of metastases to the CLNs were 100 and 50%, respectively (p < 0.05).
  • EUS was able to detect small metastases (less than 1 cm) often missed by CT.
  • Metastasis to the CLNs was a predictor of poor survival of subjects with non-small cell lung cancer, irrespective of the size of the CLNs.
  • Of 44 cases with resectable tumor on CT scan, EUS-FNA avoided thoracotomy in 14% of cases.
  • CONCLUSIONS: EUS-FNA as a first test (after CT) has high diagnostic yield and accuracy for detecting lung cancer metastases to the mediastinum and distant sites.
  • Metastasis to the CLNs is associated with poor prognosis.
  • EUS-FNA is able to detect occult metastasis to the CLNs and thus avoids thoracotomy.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Non-Small-Cell Lung / diagnosis. Carcinoma, Small Cell / diagnosis. Endosonography. Lung Neoplasms / diagnosis
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Fluorodeoxyglucose F18. Humans. Lymphatic Metastasis / diagnosis. Male. Middle Aged. Neoplasm Metastasis / diagnosis. Positron-Emission Tomography. Proportional Hazards Models. Prospective Studies. Radiopharmaceuticals. Survival Analysis. Tomography, X-Ray Computed

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  • [CommentIn] Am J Respir Crit Care Med. 2007 Feb 15;175(4):297-9 [17277288.001]
  • [CommentIn] Am J Respir Crit Care Med. 2007 Jun 1;175(11):1208; author reply 1209 [17519348.001]
  • [CommentIn] Am J Respir Crit Care Med. 2007 Jun 1;175(11):1208-9; author reply 1209 [17519349.001]
  • (PMID = 17068326.001).
  • [ISSN] 1073-449X
  • [Journal-full-title] American journal of respiratory and critical care medicine
  • [ISO-abbreviation] Am. J. Respir. Crit. Care Med.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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11. Bavi P, Shet T, Gujral S: Malignant melanoma of mediastinum misdiagnosed as a spindle cell thymoma in a fine needle aspirate: a case report. Acta Cytol; 2005 Jul-Aug;49(4):424-6
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  • [Title] Malignant melanoma of mediastinum misdiagnosed as a spindle cell thymoma in a fine needle aspirate: a case report.
  • BACKGROUND: Malignant melanomas in the medastinum are extremely rare.
  • Both primary melanomas and metastatic lesions from a primary elsewhere can occur in the mediastinum.
  • Aspiration biopsy of a melanoma at this unusual site may pose problems in diagnosis.
  • CASE: A 35-year-old woman presented with an anterior mediastinal mass.
  • Subsequent histology revealed a malignant melanoma.
  • CONCLUSION: This case stresses that the cytopathologist should keep in mind the remote differential diagnosis of a malignant melanoma while evaluating spindle cell neoplasms of the mediastinum, especially in tumors with prominent cell dispersal and with cells that have prominent nucleoli even without melanin pigment.
  • Accurate diagnosis helps in evaluating patients and avoids unnecessary surgery when the lesion represents a metastasis to the mediastinum from a primary elsewhere.
  • [MeSH-major] Mediastinal Neoplasms / diagnosis. Melanoma / diagnosis. Thymoma / diagnosis. Thymus Neoplasms / diagnosis

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  • (PMID = 16124173.001).
  • [ISSN] 0001-5547
  • [Journal-full-title] Acta cytologica
  • [ISO-abbreviation] Acta Cytol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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12. Oleksy P, Pogrzebielski A, Karska-Basta I, Romanowska-Dixon B: A case of choroidal metastasis in a male breast cancer. Klin Oczna; 2010;112(10-12):311-3
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  • [Title] A case of choroidal metastasis in a male breast cancer.
  • PURPOSE: We present a case of male patient under therapy due to breast cancer with choroid metastasis and exudative retinal detachment in right eye.
  • MATERIAL AND METHODS: A 59 years old male patient was referred with diagnosis of intraocular tumor in right eye Three years ago radical right-side mastectomy was performed (T2N1M0).
  • The medical history revealed that the patient was under chemo- and hormontherapy due to right breast cancer with lungs, liver and mediastinum metastases.
  • Based on the ophthalmological examination the diagnosis of intraocular tumor was established--choroidal metastasis with exudative retinal detachment.
  • Due to tumor size and general dissemination external beam irradiation of tumor was performed.
  • CONCLUSIONS: The majority of choroidal metastases in males are secondary to lung carcinoma, however in differential diagnosis it is necessary to consider also rare cases of breast carcinoma metastases.
  • Treatment strategy should be considered individual depending on size, localization, presence of metastases to other organs and general condition of the patient.
  • [MeSH-major] Breast Neoplasms, Male / pathology. Carcinoma, Ductal, Breast / radiotherapy. Carcinoma, Ductal, Breast / secondary. Choroid Neoplasms / radiotherapy. Choroid Neoplasms / secondary


13. Shimakawa T, Naritaka Y, Asaka S, Isohata N, Yamaguchi K, Murayama M, Konno S, Katsube T, Ogawa K, Ide H: A case of esophageal cancer with multiple lymph node metastases which responded to neoadjuvant chemotherapy (DCF therapy). Anticancer Res; 2010 Jan;30(1):221-6
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  • [Title] A case of esophageal cancer with multiple lymph node metastases which responded to neoadjuvant chemotherapy (DCF therapy).
  • It is difficult to perform radical surgery for esophageal cancer with multiple lymph node metastases.
  • The patient (a 67-year-old female) was diagnosed with esophageal cancer, T3, N4, M0, stage IVa with a large number of lymph node metastases in the mediastinum and in the abdominal cavity.
  • A complete response of the lymph node metastases in the abdominal cavity and a partial response of the esophageal lesion were achieved.
  • The cancer was diagnosed to be moderately differentiated squamous cell cancer, pT2, pN4(3c) and pstage IVa.
  • [MeSH-minor] Aged. Chemotherapy, Adjuvant. Cisplatin / administration & dosage. Female. Fluorouracil / administration & dosage. Humans. Lymphatic Metastasis. Neoadjuvant Therapy. Neoplasm Staging. Taxoids / administration & dosage

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  • (PMID = 20150639.001).
  • [ISSN] 1791-7530
  • [Journal-full-title] Anticancer research
  • [ISO-abbreviation] Anticancer Res.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Greece
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil
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14. Mitsuyama S, Anan K, Ono M: [A case of recurrent breast cancer successfully treated with capecitabine monotherapy]. Gan To Kagaku Ryoho; 2005 Aug;32(8):1153-7
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  • [Title] [A case of recurrent breast cancer successfully treated with capecitabine monotherapy].
  • A 51-year-old woman underwent pectoralis-preserving mastectomy for right breast cancer (squamous cell cancer, f, T1c, ly0, v0, N2 (18/33), p53 (3+), HER2 (2+), ER (-), PgR (-), T1cN2M0 (Stage IIIA) in March 2001, and received systemic chemotherapy using doxorubicin combined with cyclophosphamide, followed by paclitaxel.
  • In March 2002 (disease-free interval of one year), liver metastasis was revealed.
  • Since June 2003, capecitabine monotherapy (2,400 mg/day) was initiated for the liver and lymph node metastases in the mediastinum and retroperitoneum.
  • After 3 cycles, all metastases responded and a marked response has been maintained for 15 months.
  • Capecitabine monotherapy is safe and very useful for recurrent breast cancer.
  • [MeSH-major] Antimetabolites, Antineoplastic / therapeutic use. Breast Neoplasms / drug therapy. Carcinoma, Squamous Cell / drug therapy. Deoxycytidine / analogs & derivatives. Neoplasm Recurrence, Local
  • [MeSH-minor] Capecitabine. Female. Fluorouracil / analogs & derivatives. Humans. Liver Neoplasms / secondary. Mastectomy, Modified Radical. Middle Aged. Treatment Outcome

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  • (PMID = 16121919.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0W860991D6 / Deoxycytidine; 6804DJ8Z9U / Capecitabine; U3P01618RT / Fluorouracil
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15. Castillo O, Frisancho O, Palomino A: [Cecal amelanotic melanoma]. Rev Gastroenterol Peru; 2010 Oct-Dec;30(4):368-71
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  • [Transliterated title] Melanoma amelanótico en ciego.
  • Physical examination revealed no malignant skin lesions.
  • The tomography scan showed metastases in mediastinum and surgical implants were found in liver metastases and small intestine.
  • We report this case, because gastrointestinal bleeding is an unusual clinical presentation of malignant melanoma.

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  • (PMID = 21263766.001).
  • [ISSN] 1022-5129
  • [Journal-full-title] Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
  • [ISO-abbreviation] Rev Gastroenterol Peru
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Peru
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16. Notting IC, Buijs JT, Que I, Mintardjo RE, van der Horst G, Karperien M, Missotten GS, Jager MJ, Schalij-Delfos NE, Keunen JE, van der Pluijm G: Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis. Invest Ophthalmol Vis Sci; 2005 May;46(5):1581-7
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  • [Title] Whole-body bioluminescent imaging of human uveal melanoma in a new mouse model of local tumor growth and metastasis.
  • Radiodiagnostic examinations, such as ultrasonic diagnostic resonance imaging and chest radiographs plus liver enzyme studies in blood, are methods used to detect liver and other distant metastases in patients.
  • Nevertheless, the mortality rate is high, because of the frequent occurrence of metastases and the lack of systemic therapy.
  • Therefore, the development of novel anticancer strategies is urgent, and more sensitive and less invasive methods of detecting and monitoring in vivo tumor growth and metastatic disease in cancer models are needed.
  • Tumor cells were inoculated into the anterior chamber of murine eyes for induction of orthotopic growth or into the left heart ventricle to mimic hematogenous micrometastatic spread.
  • Development of metastases and tumor growth was monitored weekly by whole-body bioluminescent reporter imaging (BLI).
  • RESULTS: Injection of cancer cells into the anterior chamber of the eye of mice closely mimicked orthotopic tumor growth of uveal melanoma.
  • Tumor progression could be quantitatively monitored 3 weeks after inoculation of 10(5) OCM-1 FRT/luc cells.
  • Of the mice injected, 83% exhibited a detectable tumor within 5 weeks.
  • Intracardiac injection of tumor cells resulted in metastatic growth, especially in bone.
  • Mice had bone (maxillofacial region and femora) and visceral (lung and mediastinum) metastases after 4 to 6 weeks.
  • CONCLUSIONS: BLI enables continuous quantitative monitoring in the same animal of growth kinetics for each tumor and its metastases.
  • This model will accelerate the understanding of the pathogenesis and treatment of uveal melanoma and metastasis.
  • [MeSH-major] Bone Neoplasms / secondary. Diagnostic Imaging / methods. Disease Models, Animal. Melanoma / pathology. Melanoma / secondary. Uveal Neoplasms / pathology
  • [MeSH-minor] Animals. Anterior Chamber / pathology. Female. Heart Neoplasms / pathology. Humans. Luciferases / genetics. Luciferases / metabolism. Luminescent Agents / metabolism. Luminescent Measurements. Mice. Mice, Inbred BALB C. Neoplasm Transplantation. Transfection. Tumor Cells, Cultured

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  • (PMID = 15851554.001).
  • [ISSN] 0146-0404
  • [Journal-full-title] Investigative ophthalmology & visual science
  • [ISO-abbreviation] Invest. Ophthalmol. Vis. Sci.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Luminescent Agents; EC 1.13.12.- / Luciferases
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17. Satoh H, Ishikawa H, Kagohashi K, Kurishima K, Sekizawa K: Axillary lymph node metastasis in lung cancer. Med Oncol; 2009;26(2):147-50
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  • [Title] Axillary lymph node metastasis in lung cancer.
  • STUDY OBJECTIVES: Axillary lymph node metastasis (ALNM) from lung cancer is rare.
  • To evaluate clinicopatholgical characteristics of such lung cancer patients, we performed a retrospective study of them, who had ALNM at the time of initial presentation or developed ALNM in their clinical courses.
  • METHODS: We reviewed the medical records and pathological reports of all patients at our division who had a diagnosis of primary lung cancer from January 1985 through August 2007.
  • In eight of them, ALNM was detected at the time of initial diagnosis, and two patients developed ALNM in their clinical courses.
  • Lymphatic metastasis to mediastinum was evident in all patients.
  • Three patients had distant metastases other than axillary or cervical lymph nodes.
  • CONCLUSIONS: The most likely mechanism for axillary node involvement is intercostal lymphatics via spread from mediastinal lymph node metastasis.
  • Routine palpation of the axillae is recommended if chest wall invasion, mediastinal and/or supraclavicular lymph nodes are found either at initial presentation or at follow-up of patients.
  • [MeSH-minor] Aged. Axilla. Humans. Lymph Nodes / radiography. Lymphatic Metastasis. Middle Aged. Retrospective Studies

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  • (PMID = 18821066.001).
  • [ISSN] 1357-0560
  • [Journal-full-title] Medical oncology (Northwood, London, England)
  • [ISO-abbreviation] Med. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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18. Hu YY, Liang PY, Lin XP, Zhang X, Zhang WG, Fan W: [18F-FDG PET/CT for the detection of primary tumors metastasizing to lymph nodes of the neck]. Ai Zheng; 2009 Mar;28(3):312-7
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  • BACKGROUND AND OBJECTIVE: Lymph node metastases are commonly seen in malignant tumors of the head and neck.
  • METHODS: In total 93 patients with pathologically confirmed neck lymph node metastases from unknown primary tumors underwent (18)F-FDG PET/CT in Sun Yat-sen University Cancer Center between June 2005 to April 2008 were entered into this study.
  • The primary tumors of patients were initially diagnosed according to different PET/CT standards as definite diagnosis, suspicious diagnosis and no signs of primary tumors.
  • All diagnosis based on PET/CT images were verified by pathological exams or additional imaging tests.
  • RESULTS: Forty cases made definite diagnosis by PET/CT were all confirmed by pathological or clinical exams, with a positive predictive value of 100%.
  • Of 28 cases made suspicious diagnosis, 16 were pathologically confirmed, with a positive predictive value of 57.1%.
  • Two patients, who were suggested lymph node metastases in mediastinum without the sign of the primary tumor by PET/CT, were clinically verified as primary mediastinal lung cancer.
  • The total detection rate of PET/CT for the primary tumor was 60.2% (56/93).
  • [MeSH-major] Esophageal Neoplasms / diagnosis. Fluorodeoxyglucose F18. Hypopharyngeal Neoplasms / diagnosis. Nasopharyngeal Neoplasms / diagnosis. Positron-Emission Tomography / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Follow-Up Studies. Humans. Lung Neoplasms / diagnosis. Lymph Nodes / pathology. Lymph Nodes / radiography. Lymph Nodes / radionuclide imaging. Lymphatic Metastasis. Male. Mediastinal Neoplasms / diagnosis. Middle Aged. Neck. Pyriform Sinus / radiography. Pyriform Sinus / radionuclide imaging. Radiopharmaceuticals. Tomography, X-Ray Computed / methods. Young Adult

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  • (PMID = 19619449.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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19. Dose-Schwarz J, Mahner S, Schirrmacher S, Jenicke L, Müller V, Habermann CR, Brenner W: [Detection of metastases in breast cancer patients: comparison of FDG PET with chest X-ray, bone scintigraphy and ultrasound of the abdomen]. Nuklearmedizin; 2008;47(3):97-103
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  • [Title] [Detection of metastases in breast cancer patients: comparison of FDG PET with chest X-ray, bone scintigraphy and ultrasound of the abdomen].
  • Distant metastases at primary diagnosis are a prognostic key factor in breast cancer patients and play a central role in therapeutic decisions.
  • Although FDG PET detects metastatic disease with high accuracy, its diagnostic value in breast cancer still needs to be defined.
  • PATIENTS, METHODS: A retrospective analysis of 119 breast cancer patients who presented for staging was performed.
  • Each imaging modality was independently assessed and classified for metastasis (negative, equivocal and positive.
  • RESULTS: FDG-PET detected distant metastases with a sensitivity of 87.3% and a specificity of 83.3%.
  • Regarding different locations of metastases the sensitivity of FDG PET was superior in the detection of pulmonary metastases and lymph node metastases of the mediastinum in comparison to chest x-ray, whereas the sensitivity of FDG PET in the detection of bone and liver metastases was comparable with bone scintigraphy and ultrasound of the abdomen.
  • CONCLUSIONS: FDG-PET is more sensitive than conventional imaging procedures for detection of distant breast cancer metastases and should be considered for additional staging especially in patients with high risk primary breast cancer.
  • [MeSH-major] Abdomen / ultrasonography. Breast Neoplasms / radiography. Breast Neoplasms / radionuclide imaging. Breast Neoplasms / secondary. Fluorodeoxyglucose F18. Positron-Emission Tomography / methods
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Humans. Middle Aged. Neoplasm Metastasis / radiography. Neoplasm Metastasis / radionuclide imaging. Radiography, Thoracic. Retrospective Studies

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  • (PMID = 18493688.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] ger
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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20. Płachcińska A, Mikołajczak R, Kozak J, Rzeszutek K, Kuśmierek J: Comparative analysis of 99mTc-depreotide and 99mTc-EDDA/HYNIC-TOC thorax scintigrams acquired for the purpose of differential diagnosis of solitary pulmonary nodules. Nucl Med Rev Cent East Eur; 2006;9(1):24-9
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  • [Title] Comparative analysis of 99mTc-depreotide and 99mTc-EDDA/HYNIC-TOC thorax scintigrams acquired for the purpose of differential diagnosis of solitary pulmonary nodules.
  • BACKGROUND: Aiming at comparison of diagnostic efficacy of 2 radiopharmaceuticals: 99mTc-depreotide (Neospect, Amersham) and 99mTc-EDDA/HYNIC-Tyr3-octreotide (Tektrotyd, Polatom), in differentiation between malignant and benign etiology of solitary pulmonary nodules (SPNs), radionuclide studies with 2 radiotracers were performed in 18 patients.
  • Additionally, uptake intensity of both radiotracers in nodules was assessed semiquantitatively, using a tumour-to-background ratio.
  • Verification of scintigraphic results was based in 14 cases upon a pathological examination of tumour samples (histopathology) and in the remaining 4 - on clinical observation and bacteriological studies.
  • In 6 patients a malignant etiology--lung cancer--was revealed (5--adenocarcinoma, 1--squamous cell) and the other 12 cases turned out to be benign (4 hamartomas, 3 tuberculomas, a tuberculous infiltrate, an alien body with inflammatory reaction, a hyperplasia of lymphatic tissue and 2 cases of unknown etiology, from which one had a stable size and the other resolved during a 6 month observation period).
  • In all 6 cases of lung cancer positive results were obtained with both tracers.
  • Moreover, in 2 patients metastases in mediastinum could be observed on scintigrams obtained with both radiopharmaceuticals.
  • Moreover, 99mTc-depreotide additionally revealed mediastinal and hilar lesions in 9 patients with benign lesions and 99mTc-EDDA/HYNIC-TOC - in 8.
  • However, mean values of tumour-to-lung-background ratio were equal for both radiotracers (2.2 in malignant and 1.4 in benign lesions, respectively).
  • A substantial number of false positive lesions in mediastinal and hilar regions in patients without a neoplastic process hamper the usefulness of both radiotracers for effective detection of lung cancer metastases to lymph nodes.
  • [MeSH-major] Edetic Acid / analogs & derivatives. Octreotide / analogs & derivatives. Organotechnetium Compounds. Radiopharmaceuticals. Solitary Pulmonary Nodule / diagnosis. Solitary Pulmonary Nodule / radionuclide imaging. Somatostatin / analogs & derivatives. Thorax / radionuclide imaging
  • [MeSH-minor] Adult. Aged. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Radionuclide Imaging / methods

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  • (PMID = 16791800.001).
  • [ISSN] 1506-9680
  • [Journal-full-title] Nuclear medicine review. Central & Eastern Europe
  • [ISO-abbreviation] Nucl Med Rev Cent East Eur
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Poland
  • [Chemical-registry-number] 0 / Organotechnetium Compounds; 0 / Radiopharmaceuticals; 0 / technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide; 51110-01-1 / Somatostatin; 5657-17-0 / EDDA; 9G34HU7RV0 / Edetic Acid; 9M48M2SF02 / technetium Tc 99m depreotide; RWM8CCW8GP / Octreotide
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21. Satoh E, Maruyama M, Uehira D, Koike T, Mitsuhashi Y, Ebana K, Ohinata R, Koide A, Sanada T, Maruyama S, Sakoma T: [Two case reports of metastatic liver carcinoma with the effective treatment of radiofrequency ablation and intraarterial chemotherapy]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2196-7
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  • [Title] [Two case reports of metastatic liver carcinoma with the effective treatment of radiofrequency ablation and intraarterial chemotherapy].
  • We report two cases of metastatic liver carcinoma with the treatment of radiofrequency ablation (RFA) and intraarterial chemotherapy.
  • The 57-year-old man of Case 1 had resectable multiple liver metastases of rectal carcinoma in November 2007.
  • The 66-year-old man of Case 2 had unresectable multiple liver metastases of locally-advanced esophageal carcinoma in July 2006.
  • After this treatment, solitary brain metastasis and lymph node metastasis of mediastinum were found and treated, and now he has been alive with systemic chemotherapy.
  • [MeSH-major] Catheter Ablation. Esophageal Neoplasms / pathology. Liver Neoplasms / secondary. Liver Neoplasms / therapy. Rectal Neoplasms / pathology

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  • (PMID = 20037368.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] U3P01618RT / Fluorouracil
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22. Xiao YJ, Zheng SB, Tan WL, Chen T, Qi H, Shao ZQ, Jiang YD, Wu P, Zhang HJ: [Nephron-sparing surgery for small renal cell carcinoma: clinical analysis of 21 cases]. Di Yi Jun Yi Da Xue Xue Bao; 2005 Mar;25(3):357-9
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  • METHODS: Nephron-sparing surgery was performed in 21 patients with renal cell carcinoma including 1 with solitary kidney, 3 with unilateral tumor and contralateral renal compromise, and 17 with unilateral tumor and normal contralateral kidney.
  • The tumor diameter in 17 patients with normal contralateral kidney was less than 4 cm (mean 2.5 cm) and the average diameter in 4 patients with contralateral renal compromise was 4.2 cm.
  • Of the 21 patients, 4 underwent tumor enucleation, 10 polar nephrectomy and 7 wedge resection.
  • One patient suffered a right lung and mediastinum metastasis 3 years after the surgery later and 1 with chronic glomerulonephritis required dialysis 27 months after the operation.
  • CONCLUSION: As a safe and effective therapy for early-stage small renal cell carcinoma, nephron-sparing surgery can be considered as the gold-standard therapy for patients with lesions less than 4 cm in T(1) and T(2) stages of localized unilateral tumor with normal contralateral kidney.

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  • (PMID = 15772014.001).
  • [ISSN] 1000-2588
  • [Journal-full-title] Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
  • [ISO-abbreviation] Di Yi Jun Yi Da Xue Xue Bao
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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23. Krdzalic G, Mesic D, Iljazovic E, Brkic S, Krdzalic A, Ramic N, Aljic Z, Musanovic N: Mediastinal lymph node metastasis pattern in clinically N0 non-small-cell lung cancer patients who underwent surgical resection. Med Arh; 2010;64(6):332-4
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  • [Title] Mediastinal lymph node metastasis pattern in clinically N0 non-small-cell lung cancer patients who underwent surgical resection.
  • The aim of this study was to evaluate the incidence, clinical data and patterns of mediastinal lymph node metastasis (pN2) in non-small-cell lung cancer patients who underwent systematic mediastinal lymph node dissection (SMLND).
  • We retrospectively studied 140 consecutive patients [125 male and 15 female, mean ages 54.61 +/- 9.23 years (range, 21-75)], underwent SMLND and major lung resections due to non-small lung cancer (NSCLC), from January 2005 till December 2009.
  • Preoperative clinical staging for mediastinal lymph node metastasis was negative (cN0) in all patients.
  • SMLND was defined as a complete removal of mediastinal lymph nodes.
  • Lymph node metastasis to the mediastinum was confirmed in 13 (9.28%) patients.
  • In squamous cell cancer pN2 were in 8 (5.71%) cases out of 82 cases with cN0.
  • Unvaried analysis revealed central tumor site as predictive factor for mediastinal lymph node involvement.
  • The upper mediastinal compartment was infiltrated in 12 (8.57%) cases, middle in 8 (5.71%) and lower in 3 (2.14%) cases.
  • We concluded that SMLND improves pTNM staging in lung cancer patients who underwent major lung resections with central location of the tumour.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Pneumonectomy. Young Adult

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  • (PMID = 21218749.001).
  • [Journal-full-title] Medicinski arhiv
  • [ISO-abbreviation] Med Arh
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Bosnia and Herzegovina
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24. Lee PC, Port JL, Korst RJ, Liss Y, Meherally DN, Altorki NK: Risk factors for occult mediastinal metastases in clinical stage I non-small cell lung cancer. Ann Thorac Surg; 2007 Jul;84(1):177-81
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Risk factors for occult mediastinal metastases in clinical stage I non-small cell lung cancer.
  • BACKGROUND: In patients deemed to have clinical stage I for non-small cell lung cancer (NSCLC) after computerized tomography (CT) and positron emission tomography (PET) scans, the utility of mediastinoscopy to detect occult mediastinal metastases is unclear.
  • The goal of this study was to analyze the risk factors for occult mediastinal metastases in this subset of patients.
  • Medical records were reviewed, and the prevalence of pathologic N2 disease was analyzed according to clinical tumor location, size, histology, and PET uptake of the primary tumor.
  • RESULTS: Of 224 patients identified with clinical stage I NSCLC with a CT-negative and PET-negative mediastinum, 16 patients had pathologic N2 disease proven by mediastinoscopy (n = 11) or after resection (n = 5).
  • All 16 patients with occult N2 metastases had adenocarcinoma as the primary tumor cell type.
  • When the PET maximum standardized uptake value (SUV(max)) of the primary tumors was analyzed, patients with occult N2 metastases had a higher median SUV(max) of the primary tumor compared with patients without N2 metastases, 6.0 g/mL versus 3.6 g/mL (p = 0.017).
  • CONCLUSIONS: For patients deemed at clinical stage I NSCLC by CT and PET, the prevalence of missed N2 metastases increased significantly with larger tumor size and central location.
  • Adenocarcinoma cell type and a high PET SUV(max) of the primary tumor were other risk factors.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Mediastinal Neoplasms / secondary
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Fluorodeoxyglucose F18. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Retrospective Studies. Risk Factors. Tomography, X-Ray Computed

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  • (PMID = 17588407.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Netherlands
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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25. Kagel T, Lemburg SP, Müller KM, Laczkovics A, Nicolas V, Heyer CM: [Mediastinal metastasis of a tubal choriocarcinoma following ectopic pregnancy as a rare cause of thoracic pain]. Zentralbl Gynakol; 2006 Apr;128(2):90-4
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Mediastinal metastasis of a tubal choriocarcinoma following ectopic pregnancy as a rare cause of thoracic pain].
  • [Transliterated title] Mediastinale Metastase eines tubaren Chorionkarzinoms nach ektoper Schwangerschaft als seltene Ursache thorakaler Schmerzen.
  • We report on a 26-year old female patient with thoracic pain and dyspnea, in whom a large tumorous mass in the anterior mediastinum with a pleural effusion was diagnosed by computed tomography and magnetic resonance imaging.
  • After rapid progression of tumor growth and detection of malignant cells within the pleural effusion operative intervention including resection of the tumor was performed.
  • Histologic examination of the tumor revealed the typical morphology of a large mediastinal choriocarcinoma.
  • Although primary histologic examination of the tubarian tissue had shown no malignancy, a secondary look revealed a choriocarcinoma with identical histological features compared to the mediastinal tumor.
  • Thus, final diagnosis of a mediastinal metastasis of a tubarian choriocarcinoma in ectopic pregnancy was made.
  • [MeSH-major] Choriocarcinoma / secondary. Fallopian Tube Neoplasms / diagnosis. Magnetic Resonance Imaging. Mediastinal Neoplasms / secondary. Pregnancy, Tubal / diagnosis. Tomography, X-Ray Computed
  • [MeSH-minor] Adult. Fallopian Tubes / pathology. Fallopian Tubes / surgery. Female. Humans. Pleural Effusion, Malignant / diagnosis. Pleural Effusion, Malignant / pathology. Pleural Effusion, Malignant / surgery. Pregnancy


26. Ma Q, Liu D, Guo Y, Shi B, Song Z, Tian Y: Surgical therapeutic strategy for non-small cell lung cancer with mediastinal lymph node metastasis (N2). Zhongguo Fei Ai Za Zhi; 2010 Apr;13(4):342-8
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical therapeutic strategy for non-small cell lung cancer with mediastinal lymph node metastasis (N2).
  • BACKGROUND AND OBJECTIVE: Approximately 30% of patients who are diagnosed with non-small cell lung cancer (NSCLC) are classified as N2 on the basis of metastasis to the mediastinal lymph nodes.
  • The database covers the patients' complete medical history including the information of their age, sex, location and size of tumor, date of operation, surgical methods, histologic diagnosis, clinical stage, post-operative TNM stage, neoadjuvant treatment and chemoradiotherapy.
  • The pathological classification was based on the international standard for lung cancer (UICC 1997).
  • In all N2 subtypes, 5-year survival rate is remarkably higher for unexpected N2 discovered at thoractomy and proven N2 stage before preoperative work-up and receive a mediastinal down-staging after induction therapy (P < 0.01), reaching 30.4% and 27.3% respectively.
  • 5-year survival rate for single station lymph node metastasis were 27.8%, much higher compared with 9.3% for multiple stations (P < 0.001).
  • CONCLUSION: It is suggested that surgery (lobectomy preferentially) is the best solution for T1 and T2 with primary tumor have not invaded pleura or the distance to carina of trachea no less than 2 cm, unexpected N2 discovered at thoractomy when a complete resection can be applied, and proven N2 discovered during preoperative work-up and is down-staged after induction therapy.
  • Patients' survival time will not benefit from surgery if they are with lymph nodes metastasis of multiple stations (Bulky N2 included) and T4 which can be partially removed.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery. Lymphatic Metastasis / pathology. Thoracic Surgical Procedures / methods

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  • (PMID = 20677562.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] China
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27. Liu B, Zhi X, Xu Q, Zhang Y, Su L, Chen D, Wang R, Hu M, Liu L, Qian K: [Application of videomediastinoscopy in positive PET finding for mediastinal lymph node of lung cancer]. Zhongguo Fei Ai Za Zhi; 2010 Feb;13(2):168-70
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Application of videomediastinoscopy in positive PET finding for mediastinal lymph node of lung cancer].
  • BACKGROUND AND OBJECTIVE: Positron emission tomography (PET) is used increasingly in staging of non-small cell lung cancer (NSCLC) as a non-invasive tool.
  • However, the role of PET in mediastinal lymphatic staging of NSCLC is not clear.
  • The aim of this study was to demonstrate the efficacy of mediastinoscopy in determining mediastinal lymphatic metastasis in cases of positive PET finding.
  • Mediastinal lymphatic defined as metastasis by PET (SUV(max) > 2.5) was recorded.
  • Involvement of mediastinal lymph nodes was verified to compare the sensitivity and specificity of mediastinoscopy and the related PET results.
  • Localization of the tumor was right lung in 41 patients and left lung in 20 patients.
  • Ten patients with N3 mediastinal metastasis for chemotherapy, 38 patients with N2 mediastinal metastasis for neuadjuvant chemotherapy while lung resection and systemic mediastinal lymphatic dissection through thoracotomy was performed in the remaining 16 patients with no mediastinal metastasis.
  • The sensitivity, specificity, accuracy, positive prediction value and negative prediction value in diagnosis of metastasis of mediastinal lymph nodes were 93.8% (45/48), 100% (13/13), 95.1% (58/61), 100% (45/45), 81.3% (13/16) for mediastinoscopy, respectively.
  • Mediastinoscopy still remains the gold standard for mediastinal staging of NSCLC.
  • [MeSH-major] Lung Neoplasms / pathology. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Mediastinoscopy. Positron-Emission Tomography

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  • (PMID = 20673513.001).
  • [ISSN] 1009-3419
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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28. Celikoglu F, Celikoglu SI, Goldberg EP: Intratumoural chemotherapy of lung cancer for diagnosis and treatment of draining lymph node metastasis. J Pharm Pharmacol; 2010 Mar;62(3):287-95
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intratumoural chemotherapy of lung cancer for diagnosis and treatment of draining lymph node metastasis.
  • OBJECTIVES: Reviewed here is the potential effectiveness of cytotoxic drugs delivered by intratumoural injection into endobronchial tumours through a bronchoscope for the treatment of non-small cell lung cancer and the diagnosis of occult or obvious cancer cell metastasis to mediastinal lymph nodes.
  • KEY FINDINGS: Intratumoural lymphatic treatment may be achieved by injection of cisplatin or other cytotoxic drugs into the malignant tissue located in the lumen of the airways or in the peribronchial structures using a needle catheter through a flexible bronchoscope.
  • This procedure is termed endobronchial intratumoural chemotherapy and its use before systemic chemotherapy and/or radiotherapy or surgery may provide a prophylactic or therapeutic treatment for eradication of micrometastases or occult metastases that migrate to the regional lymph nodes draining the tumour area.
  • In this light, the potential efficacy of intratumoural chemotherapy for prophylaxis and locoregional therapy of cancer metastasis via the sentinel and regional lymph nodes is indicated.
  • Randomized multicenter clinical studies are needed to evaluate this new and safe procedure designed to improve the condition of non-small cell lung cancer patients and prolong their survival.
  • [MeSH-major] Antineoplastic Agents / administration & dosage. Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / drug therapy
  • [MeSH-minor] Bronchoscopes. Early Detection of Cancer / methods. Humans. Injections, Intralesional / methods. Lymphatic Metastasis / diagnosis. Lymphatic Metastasis / radionuclide imaging. Lymphatic System / physiology. Lymphatic System / physiopathology. Lymphoscintigraphy

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  • (PMID = 20487210.001).
  • [ISSN] 2042-7158
  • [Journal-full-title] The Journal of pharmacy and pharmacology
  • [ISO-abbreviation] J. Pharm. Pharmacol.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Antineoplastic Agents
  • [Number-of-references] 61
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29. Ki KD, Lee JM, Tong SY, Lee SK, Kim DH, Kwak YT, Lim SJ: Video-assisted thoracoscopic surgery for recurrent ovarian cancer with a metastatic mediastinal mass. Onkologie; 2009 May;32(5):274-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Video-assisted thoracoscopic surgery for recurrent ovarian cancer with a metastatic mediastinal mass.
  • BACKGROUND: Although primary cytoreductive surgery is well accepted as a cornerstone of the management for epithelial ovarian cancer, the benefits of secondary cytoreduction in recurrent ovarian cancer remain unclear.
  • Furthermore, no consensus has been reached regarding treatment strategies for extraperitoneal metastasis.
  • CASE REPORT: A 29-year-old woman was admitted to our hospital due to suspected recurrent ovarian cancer.
  • Preoperative evaluation revealed a palpable inguinal mass and multiple enlarged pelvic lymph nodes with a well-defined mediastinal mass on abdomino-pelvic and chest computed tomography.
  • Secondary debulking combined with video-assisted thoracoscopic surgery (VATS) was performed.
  • CONCLUSION: VATS may be a reasonable option for secondary debulking in selected patients with isolated mediastinal metastasis.
  • [MeSH-major] Adenocarcinoma / secondary. Adenocarcinoma / surgery. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / surgery. Neoplasm Recurrence, Local / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Thoracic Surgery, Video-Assisted / methods
  • [MeSH-minor] Adult. Female. Humans. Lymphatic Metastasis. Surgery, Computer-Assisted / methods. Treatment Outcome

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  • [Copyright] Copyright (c) 2009 S. Karger AG, Basel.
  • (PMID = 19420974.001).
  • [ISSN] 1423-0240
  • [Journal-full-title] Onkologie
  • [ISO-abbreviation] Onkologie
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Switzerland
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30. Morikawa M, Demura Y, Ishizaki T, Ameshima S, Miyamori I, Sasaki M, Tsuchida T, Kimura H, Fujibayashi Y, Okazawa H: The effectiveness of 18F-FDG PET/CT combined with STIR MRI for diagnosing nodal involvement in the thorax. J Nucl Med; 2009 Jan;50(1):81-7
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • The purpose of this study was to compare the efficacy of short-tau inversion-recovery (STIR) MRI and 18F-FDG PET/CT for the detection of metastasis in mediastinal and hilar lymph nodes in patients with lung cancer.
  • METHODS: Ninety-three patients with known or suspected lung cancer with mediastinal and hilar lymph node swelling underwent STIR MRI and 18F-FDG PET/CT examinations.
  • RESULTS: A total of 137 lymph nodes (82 malignant lesions, 55 benign lesions) were analyzed.
  • [MeSH-major] Fluorodeoxyglucose F18. Lung Neoplasms / pathology. Lymphatic Metastasis / radiography. Lymphatic Metastasis / radionuclide imaging. Radiography, Thoracic. Thorax / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Magnetic Resonance Imaging. Male. Mediastinal Neoplasms / radiography. Mediastinal Neoplasms / radionuclide imaging. Mediastinal Neoplasms / secondary. Middle Aged. Neoplasm Staging. Phantoms, Imaging. Positron-Emission Tomography. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 19091887.001).
  • [ISSN] 0161-5505
  • [Journal-full-title] Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • [ISO-abbreviation] J. Nucl. Med.
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
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31. Brichkov I, Keller SM: Intraoperative staging and surgical management of stage IIIA/N2 non-small cell lung cancer. Thorac Surg Clin; 2008 Nov;18(4):381-91
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Intraoperative staging and surgical management of stage IIIA/N2 non-small cell lung cancer.
  • Staging of the mediastinum is an integral component of the operative treatment of NSCLC.
  • During surgery for a right lung cancer, at least mediastinal lymph node levels 4 should be sampled or dissected.
  • When removing a left lung cancer, at least nodal levels 5 and 7 should be assessed.
  • Although every effort should be made to identify N2 disease before surgery, if intraoperative metastases to mediastinal lymph nodes are discovered, the planned operation should proceed.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / pathology. Lung Neoplasms / surgery. Pneumonectomy / methods
  • [MeSH-minor] Humans. Intraoperative Period. Lymphatic Metastasis. Neoplasm Staging

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  • (PMID = 19086607.001).
  • [ISSN] 1547-4127
  • [Journal-full-title] Thoracic surgery clinics
  • [ISO-abbreviation] Thorac Surg Clin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 39
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32. Watanabe S, Suzuki K, Asamura H: Superior and basal segment lung cancers in the lower lobe have different lymph node metastatic pathways and prognosis. Ann Thorac Surg; 2008 Mar;85(3):1026-31
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Superior and basal segment lung cancers in the lower lobe have different lymph node metastatic pathways and prognosis.
  • BACKGROUND: Although the lower lobe is a large entity that occupies half of the hemithorax, all tumors located within the lower lobe have been treated uniformly regardless of tumor location.
  • The aim of this study was to reveal differences in the metastatic pathway to the mediastinum and in prognosis of N2 disease between lung cancers originating from superior and basal segment of the lower lobe.
  • METHODS: Data on 139 patients who underwent pulmonary resection with systematic nodal dissection for pN2 non-small cell lung cancer (NSCLC) originating from the lower lobe between 1980 and 2001 were retrospectively reviewed.
  • RESULTS: The superior segment group showed a significantly higher incidence of superior mediastinal metastasis than the basal segment group (64% vs 36%, p = 0.0012).
  • When superior mediastinal metastasis existed, the basal segment group showed a significantly higher incidence of synchronous subcarinal metastasis than the superior segment group (81% vs 39%, p = 0.0006).
  • The basal segment origin tumors with only subcarinal metastasis showed significantly better prognosis than other lower lobe N2 tumors (5-year survival, 43% vs 18%; p = 0.0155).
  • CONCLUSIONS: Basal segment tumor metastasizes to the superior mediastinum mostly through the subcarinal node, whereas superior segment tumors often metastasize directly to the superior mediastinum without concomitant metastasis to the subcarinal node.
  • Superior mediastinal dissection will be mandatory for accurate staging of superior segment tumors even when the subcarinal node is negative on frozen section.
  • As for the prognosis among lower lobe N2 tumors, only in cases with basal segment tumor without superior mediastinal metastasis may long-term survival be expected.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Retrospective Studies. Survival Rate

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  • (PMID = 18291191.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Netherlands
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33. Watanabe S, Asamura H, Suzuki K, Tsuchiya R: The new strategy of selective nodal dissection for lung cancer based on segment-specific patterns of nodal spread. Interact Cardiovasc Thorac Surg; 2005 Apr;4(2):106-9

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The new strategy of selective nodal dissection for lung cancer based on segment-specific patterns of nodal spread.
  • A new strategy for selective nodal dissection in non-small cell lung cancer (NSCLC) patients according to the segment of primary tumor was explored.
  • In right upper lobe (RUL) tumor, when the pretracheal node was negative, the incidence of subcarinal involvement was 3.8%.
  • In lower lobe tumor, superior segment (RLL-Superior and LLL-Superior) tumor showed a significantly higher incidence of superior mediastinal involvement than basal segment (RLL-Basal and LLL-Basal) tumor (right, P=0.0036; left, P=0.0499).
  • When the subcarinal node was negative, the incidence of superior mediastinal metastasis in RLL-basal and LLL-Basal tumor was 11% and 8%, respectively.
  • In left upper lobe tumor, superior segment (LUL-Superior) tumor showed a significantly lower incidence of subcarinal involvement than lingular segment (LUL-Lingular) tumor (P=0.0381).
  • When aortic nodes were negative in LUL-Superior tumor, the incidence of subcarinal metastasis was 6%.
  • Collectively, in RUL and LUL-Superior tumors, subcarinal dissection may be unnecessary if superior mediastinal node is negative.
  • In RLL-Basal and LLL-Basal tumors, superior mediastinal dissection may be unnecessary if subcarinal node is negative.

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  • (PMID = 17670367.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
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34. Li LR, Wan DS, Pan ZZ, Zhou ZW, Chen G, Wu XJ, Lu ZH, Ding PR: [Clinical features and treatment of 49 patients with anal canal adenocarcinoma]. Zhonghua Wei Chang Wai Ke Za Zhi; 2006 Sep;9(5):402-4
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  • Local recurrence and inguinal lymph node metastasis were found in 7 cases respectively, lung metastasis in 2, supraclavicular and mediastinal metastasis in 1 respectively.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Anal Canal / pathology. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Rate. Young Adult

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  • (PMID = 17043960.001).
  • [ISSN] 1671-0274
  • [Journal-full-title] Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
  • [ISO-abbreviation] Zhonghua Wei Chang Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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35. Tsutsui M, Yoshino S, Sakamoto K, Oka M: [Long-term survival after surgery and adjuvant imatinib in a patient with rectal GIST, local recurrence, liver metastases and mediastinal pleural metastasis]. Gan To Kagaku Ryoho; 2009 Nov;36(12):2351-3
Hazardous Substances Data Bank. IMATINIB MESYLATE .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Long-term survival after surgery and adjuvant imatinib in a patient with rectal GIST, local recurrence, liver metastases and mediastinal pleural metastasis].
  • Imatinib is a standard treatment for metastatic GIST.
  • Surgery is an optional treatment for local recurrence and resectable liver metastasis.
  • We report a case of high risk group rectal GIST with local recurrence, liver metastases and mediastinal pleural metastasis.
  • A 63-year-old man underwent a surgery for undifferentiated esophageal cancer and simultaneously was diagnosed a rectal submucosal tumor of 3 cm by digital examination in 2001.
  • After 2 years, he underwent Miles' operation because of an increase of the rectal submucosal tumor.
  • PET-CT and CT pointed out a local recurrence and liver metastases that were resected in 2004.
  • In 2008, he received a resection of mediastinal pleural metastasis.
  • Combined modality therapy with surgery and chemotherapy for the metastatic GIST may contribute to a long-term survival.
  • [MeSH-major] Antineoplastic Agents / therapeutic use. Gastrointestinal Stromal Tumors / therapy. Liver Neoplasms / secondary. Piperazines / therapeutic use. Pleural Neoplasms / secondary. Pyrimidines / therapeutic use. Rectal Neoplasms / therapy
  • [MeSH-minor] Administration, Oral. Benzamides. Chemotherapy, Adjuvant. Humans. Imatinib Mesylate. Male. Mediastinum. Middle Aged. Neoplasm Recurrence, Local

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  • (PMID = 20037419.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antineoplastic Agents; 0 / Benzamides; 0 / Piperazines; 0 / Pyrimidines; 8A1O1M485B / Imatinib Mesylate
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36. Liu J, Xu ZG, Wang XL, Liu SY, Qi YF, Tang PZ: [Surgical treatment of thyroid carcinoma with the upper mediastinal metastasis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2007 Apr;42(4):277-80
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical treatment of thyroid carcinoma with the upper mediastinal metastasis].
  • OBJECTIVE: To study the clinical characteristics and management of thyroid cancer with the upper mediastinal metastasis.
  • METHODS: A retrospective study was performed to analysis the clinical characteristics, treatment and prognosis of 122 cases who underwent mediastinal dissection for thyroid cancer invasion in Cancer Hospital of Chinese Academy of Medical Science from Jan.
  • RESULTS: According to postoperative pathological diagnosis, upper mediastinal(2R/2L) were the most common areas invaded, 98.4%.
  • The incidence rate of lower mediastinal invasion was 20.5%, which often occurred in the area of lower paratracheal (4R/4L).
  • The complication rate of the sternotomy group (38.2%)was higher than the other (28.4%), but complications associated with mediastinal operation were rare, including pleural effusion (3 cases), mediastinal infection (1 case) and superior vena cava rupture (1 case), which were all cured.
  • Three-year and 5-year mediastinal recurrence rate of sternotomy group were 3.8%, 12.2%, while transcervical operation group 7.9%, 14.2%.
  • CONCLUSIONS: It is noticed that there is a big percentage of patients with lower mediastinal invasion as well as upper area lesions.
  • [MeSH-major] Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / surgery. Thyroid Neoplasms / pathology. Thyroid Neoplasms / surgery
  • [MeSH-minor] Adolescent. Adult. Aged. Aged, 80 and over. Child. Female. Humans. Lymph Node Excision. Lymphatic Metastasis. Male. Middle Aged. Prognosis. Retrospective Studies. Young Adult

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  • (PMID = 17628978.001).
  • [ISSN] 1673-0860
  • [Journal-full-title] Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
  • [ISO-abbreviation] Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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37. Nakayama J, Miyasaka K, Omatsu T, Onodera Y, Terae S, Matsuno Y, Cho Y, Hida Y, Kaga K, Shirato H: Metastases in mediastinal and hilar lymph nodes in patients with non-small cell lung cancer: quantitative assessment with diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient. J Comput Assist Tomogr; 2010 Jan;34(1):1-8
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  • [Title] Metastases in mediastinal and hilar lymph nodes in patients with non-small cell lung cancer: quantitative assessment with diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient.
  • OBJECTIVE: To evaluate diffusion-weighted magnetic resonance (DW-MR) imaging for detection of metastases in lymph nodes by using quantitative analysis.
  • METHODS: Seventy patients with non-small cell lung cancer were examined with DW and short inversion time inversion recovery (STIR) turbo-spin-echo MR imaging.
  • Apparent diffusion coefficient of each lung cancer and lymph node was calculated from DW-MR images.
  • Difference of the apparent diffusion coefficient in a lung cancer and a lymph node was calculated (D1).
  • For quantitative analysis, the threshold value for a positive test was determined on a per node basis and tested for ability to enable a correct diagnosis on a per patient basis.
  • RESULTS: Mean D1 in the lymph node group with metastases was lower than that in the group without metastases (P < 0.001).
  • CONCLUSIONS: Quantitative analysis of DW-MR images enables differentiation of lymph nodes with metastasis from those without.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / secondary. Diffusion Magnetic Resonance Imaging / methods. Lung Neoplasms / pathology. Lymph Nodes / pathology. Mediastinum / pathology
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Aged. Aged, 80 and over. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Diagnosis, Differential. Female. Humans. Lymph Node Excision / methods. Lymphatic Metastasis. Male. Middle Aged. Phantoms, Imaging. ROC Curve. Reproducibility of Results. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 20118713.001).
  • [ISSN] 1532-3145
  • [Journal-full-title] Journal of computer assisted tomography
  • [ISO-abbreviation] J Comput Assist Tomogr
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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38. Bayar GR, Gulses A, Sencimen M, Aydintug YS, Arpaci F, Gunhan O: Oral metastasis of the mediastinal germ cell tumor (yolk sac). J Craniofac Surg; 2010 Nov;21(6):1828-30
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  • [Title] Oral metastasis of the mediastinal germ cell tumor (yolk sac).
  • A yolk sac tumor is a rare malignant tumor of germ cell origin.
  • Yolk sac tumors are malignant, tend to recur locally, and may present with widespread metastases at the time of diagnosis.
  • In this study, we present the case of a 23-year-old man presenting with mandibular and adjacent gingival metastasis of a mediasatinal yolk sac tumor.
  • In this case report, clinical and histopathologic features of the oral metastases of a yolk sac tumor were briefly discussed.
  • [MeSH-major] Endodermal Sinus Tumor / secondary. Gingival Neoplasms / secondary. Mandibular Neoplasms / secondary. Mediastinal Neoplasms / pathology
  • [MeSH-minor] Humans. Lung Neoplasms / secondary. Male. Masseter Muscle / pathology. Muscle Neoplasms / secondary. Skull Neoplasms / secondary. Temporal Bone / pathology. Young Adult

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  • (PMID = 21119432.001).
  • [ISSN] 1536-3732
  • [Journal-full-title] The Journal of craniofacial surgery
  • [ISO-abbreviation] J Craniofac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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39. Chen TJ, Chiou CC, Chen CH, Kuo TT, Hong HS: Metastasis of mediastinal epithelioid angiosarcoma to the finger. Am J Clin Dermatol; 2008;9(3):181-3
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  • [Title] Metastasis of mediastinal epithelioid angiosarcoma to the finger.
  • Epithelioid angiosarcoma (EA) is a rare malignant, vascular tumor that is usually observed in middle-aged and elderly males.
  • Cutaneous metastasis of EA is extremely rare.
  • The patient had recently been diagnosed with mediastinal EA with disseminated metastases.
  • The skin biopsy specimen revealed metastatic EA.
  • This is thought to be the first reported metastasis of EA to the finger.
  • Whenever a patient has metastatic disease, acrometastases should be considered in the differential diagnosis of inflammatory lesions of the digits and a skin biopsy should be performed.
  • [MeSH-major] Fingers / pathology. Hemangioendothelioma, Epithelioid / secondary. Mediastinal Neoplasms / pathology. Skin Neoplasms / secondary
  • [MeSH-minor] Adult. Biopsy. Diagnosis, Differential. Fatal Outcome. Female. Humans

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  • (PMID = 18429648.001).
  • [ISSN] 1175-0561
  • [Journal-full-title] American journal of clinical dermatology
  • [ISO-abbreviation] Am J Clin Dermatol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] New Zealand
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40. Nakamura Y, Sato N, Kaimori K, Imai T: [Thymic carcinoid with lymph node metastases; report of a case]. Kyobu Geka; 2007 Dec;60(13):1204-7
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  • [Title] [Thymic carcinoid with lymph node metastases; report of a case].
  • A 71-year-old man was admitted to our hospital because of the detection of an anterior mediastinal tumor.
  • Fluorodeoxyglucose-positron emission tomography (FDG-PET) showed abnormal accumulations in the tumor and the hilar and the supra-clavicular lymph nodes.
  • Preoperatively, percutaneous needle biopsy of the tumor revealed thymic carcinoid.
  • Tumor resection and thymectomy with mediastinal and supra-clavicular lymph nodes dissection were performed because of suspecting metastasis to the lymph nodes from FDG-PET.
  • Postoperative pathological diagnosis revealed atypical carcinoid and metastases to the mediastinal and supra-clavicular lymph nodes.
  • In our case, FDG-PET was useful in detecting the thymic carcinoid and lymph node metastasis.
  • [MeSH-major] Carcinoid Tumor / pathology. Lymph Nodes / pathology. Lymphatic Metastasis / pathology. Thymus Neoplasms / pathology

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  • (PMID = 18078092.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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41. Peric R, Schuurbiers OC, Veseliç M, Rabe KF, van der Heijden HF, Annema JT: Transesophageal endoscopic ultrasound-guided fine-needle aspiration for the mediastinal staging of extrathoracic tumors: a new perspective. Ann Oncol; 2010 Jul;21(7):1468-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transesophageal endoscopic ultrasound-guided fine-needle aspiration for the mediastinal staging of extrathoracic tumors: a new perspective.
  • BACKGROUND: Several extrathoracic tumors metastasize to the mediastinum.
  • Mediastinoscopy is the standard method to obtain tissue proof of mediastinal spread, but drawbacks are its invasiveness, requirement for general anesthesia and costs.
  • Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is indicated in lung cancer staging guidelines as a minimally invasive alternative for surgical staging.
  • The diagnostic values in patients with suspected mediastinal metastases and various (previous) extrathoracic malignancies were assessed.
  • PATIENTS AND METHODS: Consecutive patients with suspected mediastinal metastases (on computed tomography or positron emission tomography) and an (previous) extrathoracic malignancy underwent EUS-FNA.
  • EUS-FNA detected mediastinal malignancies in 43 patients (57%) [metastases of extrathoracic tumors, n = 36 (48%); second malignancy (lung cancer), n = 7 (9%)].
  • Mediastinal metastases were found at subsequent surgical staging in seven patients or during follow-up (one patient).
  • In seven patients, an alternative diagnosis was established.
  • Sensitivity, specificity, accuracy and negative predictive value of EUS-FNA for mediastinal staging were 86%, 100%, 91% and 72%, respectively.
  • CONCLUSION: EUS-FNA is a minimally invasive mediastinal staging method for patients with extrathoracic malignancies to confirm nodal metastatic spread and therefore may qualify as an alternative for surgical staging.

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  • (PMID = 20028722.001).
  • [ISSN] 1569-8041
  • [Journal-full-title] Annals of oncology : official journal of the European Society for Medical Oncology
  • [ISO-abbreviation] Ann. Oncol.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] England
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42. Staehler M, Schöppler G, Haseke N, Stadler T, Karl A, Siebels M, Ihrler S, Stief CG: Carcinoma of the collecting ducts of Bellini of the kidney: adjuvant chemotherapy followed by multikinase inhibition with sunitinib. Clin Genitourin Cancer; 2009 Jan;7(1):58-61
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  • RESULTS: Subsequent restaging revealed local recurrence and lymph node metastases.
  • Both patients were operated on again, and metastatic CDC was found.
  • After 2 cycles, multiple liver, lung, and bone metastases and mediastinal lymphopathy occurred.
  • Eight weeks later, the patients died, with a survival of 8 months from initial diagnosis.

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  • (PMID = 19213670.001).
  • [ISSN] 1558-7673
  • [Journal-full-title] Clinical genitourinary cancer
  • [ISO-abbreviation] Clin Genitourin Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Indoles; 0 / Pyrroles; 0 / sunitinib; 0W860991D6 / Deoxycytidine; B76N6SBZ8R / gemcitabine; Q20Q21Q62J / Cisplatin
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43. Chase DM, Sparks DA, Gener M, Smith J: A unique case of ovarian psammocarcinoma with mediastinal, pulmonary, subcutaneous, and omental metastases. Arch Gynecol Obstet; 2009 Aug;280(2):283-6
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  • [Title] A unique case of ovarian psammocarcinoma with mediastinal, pulmonary, subcutaneous, and omental metastases.
  • We present a case of 45-year-old woman with ovarian psammocarcinoma who initially presented with a metastatic subcutaneous nodule, and was found to have pulmonary and mediastinal metastases.
  • We believe this to be the first report of a psammocarcinoma with these metastases.
  • Although most seem to follow an indolent course similar to that of borderline lesions of the ovary, this case demonstrates that some of these tumors may be clinically aggressive with distant metastases.
  • [MeSH-major] Cystadenocarcinoma, Serous / secondary. Lung Neoplasms / secondary. Mediastinal Neoplasms / secondary. Ovarian Neoplasms / pathology. Peritoneal Neoplasms / secondary. Soft Tissue Neoplasms / secondary
  • [MeSH-minor] Female. Humans. Lung / pathology. Mediastinum / pathology. Middle Aged. Pelvis / pathology. Subcutaneous Fat / pathology

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  • (PMID = 19096859.001).
  • [ISSN] 1432-0711
  • [Journal-full-title] Archives of gynecology and obstetrics
  • [ISO-abbreviation] Arch. Gynecol. Obstet.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
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44. Anami Y, Oguma S, Matsuda Y, Yamaki T, Sazawa Y, Komiya H, Izai J, Ota T: [Complete disappearance of metastatic lung tumors and mediastinal lymphnode in a case of hepatocellular carcinoma treated by low-dose 5-fluorouracil/cisplatin therapy]. Gan To Kagaku Ryoho; 2005 Nov;32(12):1977-80
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  • [Title] [Complete disappearance of metastatic lung tumors and mediastinal lymphnode in a case of hepatocellular carcinoma treated by low-dose 5-fluorouracil/cisplatin therapy].
  • We report a case of complete disappearance of multiple lung metastases and mediastinal lymphnode metastasis by intravenous administration of 5-fluorouracil/cisplatin (FP) after operation for primary hepatocellular carcinoma (HCC).
  • He also had a single lung metastasis at the time of diagnosis.
  • After hepatic resection for HCC, the metastatic tumor progressed and became multiple lesions with mediastinal lymphnode involvements.
  • Both lung metastases and mediastinal lymphnode metastasis were decreasing after six cycles of this therapy.
  • But all metastatic lesions were completely disappeared ten months after this therapy.
  • Low-dose FP therapy may well be useful for patients suffering from advanced HCC with distant metastasis.
  • [MeSH-major] Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Carcinoma, Hepatocellular / drug therapy. Liver Neoplasms / drug therapy. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Lymph Nodes / pathology
  • [MeSH-minor] Cisplatin / administration & dosage. Dose-Response Relationship, Drug. Drug Administration Schedule. Fluorouracil / administration & dosage. Humans. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Remission Induction

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  • (PMID = 16282739.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] Q20Q21Q62J / Cisplatin; U3P01618RT / Fluorouracil; CF regimen
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45. Kuzdzał J, Zieliński M, Papla B, Szlubowski A, Hauer Ł, Nabiałek T, Sośnicki W, Pankowski J: Transcervical extended mediastinal lymphadenectomy--the new operative technique and early results in lung cancer staging. Eur J Cardiothorac Surg; 2005 Mar;27(3):384-90; discussion 390
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transcervical extended mediastinal lymphadenectomy--the new operative technique and early results in lung cancer staging.
  • OBJECTIVE: Mediastinal staging is one of the most important problems in thoracic surgery.
  • Although the pathological examination is a generally accepted standard, none of the currently used techniques enables complete removal of all lymph node stations of the mediastinum.
  • The aim of the study is to present a new technique of transcervical extended mediastinal lymphadenctomy (TEMLA) and to analyze its value in lung cancer staging.
  • METHODS: In the prospective study of consecutive group of non-small cell lung cancer (NSCLC) patients, operated on between January and August 2004, we evaluated the usefulness of this original technique of bilateral mediastinal lymphadenectomy, assessing its accuracy and safety.
  • In patients without mediastinal metastases thoracotomy with pulmonary resection was performed and mediastinum searched for any missed lymph nodes.
  • The sensitivity, specificity and accuracy of the presented method in detecting mediastinal node metastases were: 90, 100, and 96%, respectively, whereas the positive and negative predictive values were: 100 and 95%, respectively.
  • CONCLUSIONS: The TEMLA technique is a safe and highly accurate method of mediastinal staging in NSCLC.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / pathology. Lymph Node Excision / methods
  • [MeSH-minor] Adult. Aged. Epidemiologic Methods. Female. Humans. Lymphatic Metastasis. Male. Mediastinoscopy / methods. Mediastinum. Middle Aged. Neoplasm Staging. Thoracic Surgery, Video-Assisted / adverse effects. Thoracic Surgery, Video-Assisted / methods

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  • [CommentIn] Eur J Cardiothorac Surg. 2010 Apr;37(4):780-1 [20036137.001]
  • (PMID = 15740943.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article
  • [Publication-country] England
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46. van Heel NC, Haringsma J, Spaander MC, Bruno MJ, Kuipers EJ: Esophageal stents for the relief of malignant dysphagia due to extrinsic compression. Endoscopy; 2010 Jul;42(7):536-40
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  • [Title] Esophageal stents for the relief of malignant dysphagia due to extrinsic compression.
  • BACKGROUND AND STUDY AIMS: In patients with primary esophageal cancer, luminal patency can be restored by placement of a self-expandable metal stent (SEMS).
  • The use of SEMS in patients with dysphagia caused by malignant extrinsic compression has largely been unreported.
  • In this study we evaluated the efficacy of SEMS in a large cohort of patients with malignant extrinsic compression.
  • Between 1995 and 2009, 50 consecutive patients with malignant extrinsic compression who had undergone SEMS placement were included (mean age 64 years; 37-males).
  • In the majority of patients, extrinsic esophageal compression was caused by obstructive pulmonary cancer (n = 23) and by mediastinal metastasis after esophagectomy for esophageal cancer (n = 16).
  • CONCLUSIONS: Insertion of an SEMS is an effective palliative treatment for patients with dysphagia due to malignant extrinsic compression.
  • [MeSH-major] Deglutition Disorders / therapy. Esophageal Neoplasms / therapy. Lung Neoplasms / complications. Mediastinal Neoplasms / complications. Stents

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  • (PMID = 20432203.001).
  • [ISSN] 1438-8812
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Germany
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47. Ishikawa M, Kitayama J, Kaizaki S, Sako A, Nakao K, Sugawara M, Nagawa H: Diagnosis of nasopharyngeal carcinoma metastatic to mediastinal lymph nodes by endoscopic ultrasonography-guided fine-needle aspiration biopsy. Acta Otolaryngol; 2005 Sep;125(9):1014-7
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  • [Title] Diagnosis of nasopharyngeal carcinoma metastatic to mediastinal lymph nodes by endoscopic ultrasonography-guided fine-needle aspiration biopsy.
  • We report the case of a patient with nasopharyngeal carcinoma who was diagnosed as having metastasis in mediastinal lymph nodes and successfully underwent systemic chemotherapy without surgery.
  • Cytological findings were compatible with metastatic squamous cell carcinoma from a nasopharyngeal tumor, and the clinical stage was determined as T3N2bM1 (stage IVC) because of mediastinal lymph node metastasis.
  • We thus determined the nodal status of a head and neck tumor by means of EUS-FNA.
  • In conclusion, EUS-FNA is a safe and reliable technique for evaluation of mediastinal lymphadenopathy, and is especially valuable for head and neck tumors with suspected metastasis.
  • [MeSH-major] Biopsy, Needle. Carcinoma / secondary. Nasopharyngeal Neoplasms / pathology
  • [MeSH-minor] Cytodiagnosis. Endosonography. Humans. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Ultrasonography, Interventional

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  • (PMID = 16193595.001).
  • [ISSN] 0001-6489
  • [Journal-full-title] Acta oto-laryngologica
  • [ISO-abbreviation] Acta Otolaryngol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Norway
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48. Lu Y, Goldblatt JC: Multiple mediastinal metastasis of ovarian carcinoma. Heart Lung Circ; 2005 Jun;14(2):118-20
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Multiple mediastinal metastasis of ovarian carcinoma.
  • Secondary mediastinal tumours are rare.
  • We present a case report of multiple mediastinal metastasis of ovarian cancer, a very rare occurrence with only two cases previously reported in the literature.
  • [MeSH-major] Carcinoma, Papillary / secondary. Mediastinal Neoplasms / secondary. Ovarian Neoplasms / pathology

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  • (PMID = 16352267.001).
  • [ISSN] 1443-9506
  • [Journal-full-title] Heart, lung & circulation
  • [ISO-abbreviation] Heart Lung Circ
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Australia
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49. de Groot JW, Links TP, Sluiter WJ, Wolffenbuttel BH, Wiggers T, Plukker JT: Locoregional control in patients with palpable medullary thyroid cancer: results of standardized compartment-oriented surgery. Head Neck; 2007 Sep;29(9):857-63
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  • [Title] Locoregional control in patients with palpable medullary thyroid cancer: results of standardized compartment-oriented surgery.
  • BACKGROUND: Extent of neck dissection is controversial in patients with palpable medullary thyroid cancer (MTC).
  • METHODS: We evaluated 64 MTC patients (19 hereditary, 45 sporadic) with palpable thyroid nodules (group 1, n = 35) or palpable lymph node metastases (group 2, n = 29).
  • Thirty-one percent of all patients had central, 23% ipsilateral, 14% contralateral, and 14% mediastinal, metastases.
  • All had central, 93% ipsilateral, 45% contralateral, and 52% mediastinal metastases.
  • CONCLUSIONS: Locoregional recurrence frequently occurs in palpable MTC, and tumor control may be improved by standard central, bilateral, and upper mediastinal neck dissection.
  • [MeSH-minor] Adolescent. Adult. Aged. Calcitonin / blood. Carcinoembryonic Antigen / blood. Child. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Neck Dissection. Retrospective Studies

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  • [Copyright] (c) 2007 Wiley Periodicals, Inc. Head Neck, 2007.
  • (PMID = 17427969.001).
  • [ISSN] 1043-3074
  • [Journal-full-title] Head & neck
  • [ISO-abbreviation] Head Neck
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Carcinoembryonic Antigen; 9007-12-9 / Calcitonin
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50. Punamiya V, Mehta A, Chhajed PN: Bronchoscopic needle aspiration in the diagnosis of mediastinal lymphadenopathy and staging of lung cancer. J Cancer Res Ther; 2010 Apr-Jun;6(2):134-41
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  • [Title] Bronchoscopic needle aspiration in the diagnosis of mediastinal lymphadenopathy and staging of lung cancer.
  • Transbronchial needle aspiration (TBNA) has the potential to allow adequate mediastinal staging of non-small cell lung cancer with enlarged lymph nodes in most patients without the need for mediastinoscopy.
  • Metastasis to the mediastinal lymph nodes is one of the most important factors in determining resectability and prognosis in non-small cell lung cancer.
  • The importance of TBNA as a tool for diagnosing intrathoracic lymphadenopathy as well as in the staging of lung cancer has been reported in various studies.
  • TBNA is a safe and effective procedure to diagnose mediastinal lymphadenopathy.
  • Real-time bronchoscopic ultrasound-guided TBNA is the new kid on the block, which can further enhance the sensitivity of bronchoscopy in the diagnosis of mediastinal lesions.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Lymph Nodes / pathology. Lymphatic Diseases / diagnosis
  • [MeSH-minor] Biopsy, Fine-Needle. Bronchoscopes. Humans. Lymphatic Metastasis. Mediastinum. Neoplasm Staging

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  • (PMID = 20622358.001).
  • [ISSN] 1998-4138
  • [Journal-full-title] Journal of cancer research and therapeutics
  • [ISO-abbreviation] J Cancer Res Ther
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
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51. Katada E, Nakamura T, Watanabe H, Matsukawa N, Ojika K, Sobue G: [Lambert-Eaton myasthenic syndrome associated with pulmonary squamous cell carcinoma and circulating anti-P/Q-type voltage-gated calcium channel antibody]. Rinsho Shinkeigaku; 2010 Jan;50(1):17-9
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • At age 61, chest radiograph revealed a tumor shadow in the right upper lung field.
  • This was surgically removed, and a histological diagnosis of moderately differentiated pulmonary squamous cell carcinoma was obtained.
  • After about 1 year, mediastinal metastasis was detected and 5-FU was administered.
  • Eight months later, metastasis was noted in the left frontal hemisphere, and radiosurgical therapy was performed.
  • The brain tumor gradually shrank but generalized fatigue, thirst, and gait disturbance developed after 4 months.
  • A diagnosis of LEMS was made on the basis of neurological findings including proximal muscle weakness and absent tendon reflexes; autonomic symptoms (thirst, constipation, and impotence); characteristic electromyographic findings; and circulating anti-P/Q-type VGCC antibody.


52. Bilaceroglu S, Chhajed P: Transbronchial needle aspiration: a diagnostic tool in routine bronchoscopy. J Assoc Physicians India; 2005 Sep;53:797-802
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  • The fifty six-year-old Transbronchial Needle Aspiration (TBNA) has proved its efficacy, safety and cost-effectiveness particularly in diagnosing and staging lung cancer as well as in diagnosing benign granulomatous disease: sarcoidosis and tuberculous lymphadenitis.
  • Although highly specific, the sensitivity and accuracy of TBNA may vary depending on the study methods, patient population (severity of disease) and prevalence of mediastinal metastasis.
  • [MeSH-major] Biopsy, Needle / methods. Bronchoscopy / methods. Lung Neoplasms / diagnosis

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  • (PMID = 16334626.001).
  • [ISSN] 0004-5772
  • [Journal-full-title] The Journal of the Association of Physicians of India
  • [ISO-abbreviation] J Assoc Physicians India
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] India
  • [Number-of-references] 65
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53. Annema JT, Versteegh MI, Veseliç M, Welker L, Mauad T, Sont JK, Willems LN, Rabe KF: Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer. JAMA; 2005 Aug 24;294(8):931-6
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  • [Title] Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer.
  • CONTEXT: Up to 40% of thoracotomies performed for non-small cell lung cancer are unnecessary, predominantly due to inaccurate preoperative detection of lymph node metastases and mediastinal tumor invasion (T4).
  • Mediastinoscopy and the novel, minimally invasive technique of transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) target different mediastinal lymph node stations.
  • In addition, EUS can identify tumor invasion in neighboring organs if tumors are located adjacent to the esophagus.
  • OBJECTIVE: To investigate the additional value of EUS-FNA to mediastinoscopy in the preoperative staging of patients with non-small cell lung cancer.
  • During a 3-year period (2000-2003), 107 consecutive patients with potential resectable non-small cell lung cancer underwent preoperative staging by both EUS-FNA and mediastinoscopy.
  • Patients underwent thoracotomy with tumor resection if mediastinoscopy was negative.
  • MAIN OUTCOME MEASURE: Detection of mediastinal tumor invasion (T4) and lymph node metastases (N2/N3) comparing the combined staging by both EUS-FNA and mediastinoscopy with staging by mediastinoscopy alone.
  • RESULTS: The combination of EUS-FNA and mediastinoscopy identified more patients with tumor invasion or lymph node metastases (36%; 95% confidence interval [CI], 27%-46%) compared with either mediastinoscopy alone (20%; 95% CI, 13%-29%) or EUS-FNA (28%; 95% CI, 19%-38%) alone.
  • CONCLUSION: These preliminary findings suggest that EUS-FNA, when added to mediastinoscopy, improves the preoperative staging of lung cancer due to the complementary reach of EUS-FNA in detecting mediastinal lymph node metastases and the ability to assess mediastinal tumor invasion.

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  • (PMID = 16118383.001).
  • [ISSN] 1538-3598
  • [Journal-full-title] JAMA
  • [ISO-abbreviation] JAMA
  • [Language] ENG
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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54. Fukuda A, Sudou S, Kitahara I, Komatsu D, Kobayashi N, Abe T, Fukushima T: [7 fractionated cyberknife radiotherapy for giant skull metastasis: a case report]. No Shinkei Geka; 2010 Nov;38(11):1013-7

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  • [Title] [7 fractionated cyberknife radiotherapy for giant skull metastasis: a case report].
  • This is a report on the experience of using stereotactic radiotherapy for a large symptomatic metastatic skull tumor.
  • Nineteen months after uterine cancer surgery, the patient demonstrated metastasis to the mediastinum lymph node and a tumor at the parietal bone tumor but was still undergoing observation.
  • An increase of the parietal bone tumor became evident and the appearance of right hemiplegia, aphasia, and cognitive dysfunction caused her to consult this hospital.
  • We observed a large 236 cm3 tumor spread over the subcutaneous tissue of the superior sagittal sinus, pressing the brain out of the dura mater and causing bone destruction.
  • At the follow up visit one month after the treatment, the image of the tumor had already decreased, and after three months it was confirmed that the image of the tumor had disappeared.
  • Six months after irradiation, there is no evidence of tumor regrowth or complications such as dermatopathy, cerebral edema, or necrosis.
  • In this case, though the tumor had spread widely in the subcutaneous tissue, the exposure doses were delivered at 2Gy/time and could be limited to under 70Gy.
  • It is thought that Cyberknife radiotherapy will become one of the key treatments to help improve quality of life when treating symptomatic metastatic tumors.

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  • (PMID = 21081813.001).
  • [ISSN] 0301-2603
  • [Journal-full-title] No shinkei geka. Neurological surgery
  • [ISO-abbreviation] No Shinkei Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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55. Sugiura Y, Takeuchi K, Kakizaki T, Kaseda S: [Complete response by S-1 with multiple pulmonary metastases 4 years after lung resection-a case report]. Gan To Kagaku Ryoho; 2009 Dec;36(13):2611-4
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  • [Title] [Complete response by S-1 with multiple pulmonary metastases 4 years after lung resection-a case report].
  • The patient underwent partial resection of the right upper lobe by video-assisted thoracoscopic surgery in May 2004, frozen sections of which showed poorly differentiated squamous cell carcinoma, consistent with the tumor size 2.5 x 1.7 cm.
  • Bilateral multiple lung metastases and mediastinal lymph nodes involvement were confirmed by CT.
  • [MeSH-minor] Aged. Drug Combinations. Humans. Lymph Node Excision. Male. Neoplasm Recurrence, Local. Pneumonectomy. Remission Induction

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  • (PMID = 20009464.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Antimetabolites, Antineoplastic; 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid
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56. Dağdelen S: Superior vena cava syndrome arising from subclavian vein port catheter implantation and paraneoplastic syndrome. Turk Kardiyol Dern Ars; 2009 Mar;37(2):125-7
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  • The patient had inoperable gastric cancer for which he had been receiving chemotherapy for two years.
  • Extensive lung and mediastinal metastases were also observed.
  • [MeSH-minor] Angiography / methods. Catheterization, Central Venous / adverse effects. Catheters, Indwelling / adverse effects. Humans. Lung Neoplasms / secondary. Male. Mediastinal Neoplasms / secondary. Middle Aged. Stomach Neoplasms / drug therapy. Stomach Neoplasms / pathology. Subclavian Vein. Tomography, X-Ray Computed

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  • (PMID = 19404035.001).
  • [ISSN] 1016-5169
  • [Journal-full-title] Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
  • [ISO-abbreviation] Turk Kardiyol Dern Ars
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Turkey
  • [Chemical-registry-number] 0 / Fibrinolytic Agents; EC 3.4.21.68 / Tissue Plasminogen Activator
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57. Moran CA, Suster S: Thymic carcinoma: current concepts and histologic features. Hematol Oncol Clin North Am; 2008 Jun;22(3):393-407
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  • Thymic carcinoma is a rare tumor that has traditionally posed a significant challenge for diagnosis to clinicians and histopathologists.
  • No reliable histopathologic features have yet been identified that can permit reliable distinction of these tumors from a metastasis to the mediastinum.
  • In general, these tumors remain a diagnosis of exclusion and, as a group, represent high-grade neoplasms with a very aggressive clinical behavior and an often-ominous prognosis.
  • [MeSH-major] Mediastinal Neoplasms / pathology. Thymoma / pathology. Thymus Neoplasms / pathology

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  • (PMID = 18514123.001).
  • [ISSN] 0889-8588
  • [Journal-full-title] Hematology/oncology clinics of North America
  • [ISO-abbreviation] Hematol. Oncol. Clin. North Am.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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58. Kume H, Kakutani S, Tomita K, Kitamura T: Salvage combination chemotherapy with docetaxel, ifosfamide and cisplatin (DIP): successful treatment of a case with metastatic testicular immature teratoma. Jpn J Clin Oncol; 2008 Feb;38(2):143-5
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  • [Title] Salvage combination chemotherapy with docetaxel, ifosfamide and cisplatin (DIP): successful treatment of a case with metastatic testicular immature teratoma.
  • We present a case of metastatic testicular immature teratoma that was successfully treated despite resistance to standard chemotherapy and unsuccessful salvage surgery.
  • By the time of the referral lung and mediastinal lymph node metastasis had appeared and para-aortic lymph node metastasis had grown larger.
  • We administered the DIP (docetaxel, ifosfamide and cisplatin) regimen as a second line chemotherapy, which was effective with 82% reduction of para-aortic lymph nodes, 88% of mediastinal lymph nodes and 85% of lung metastasis.
  • We performed para-aortic lymph node dissection followed by resection of lung metastasis and mediastinal lymph node dissection.
  • [MeSH-minor] Adult. Cisplatin / administration & dosage. Humans. Ifosfamide / administration & dosage. Lymph Node Excision. Lymphatic Metastasis. Male. Mediastinum. Taxoids / administration & dosage. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 18250203.001).
  • [ISSN] 1465-3621
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Taxoids; 15H5577CQD / docetaxel; Q20Q21Q62J / Cisplatin; UM20QQM95Y / Ifosfamide
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59. Sakao Y, Miyamoto H, Yamazaki A, Ou S, Shiomi K, Sonobe S, Sakuraba M: The spread of metastatic lymph nodes to the mediastinum from left upper lobe cancer: results of superior mediastinal nodal dissection through a median sternotomy. Eur J Cardiothorac Surg; 2006 Sep;30(3):543-7
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  • [Title] The spread of metastatic lymph nodes to the mediastinum from left upper lobe cancer: results of superior mediastinal nodal dissection through a median sternotomy.
  • BACKGROUND: This study endeavored to clarify the location, frequency, and prognostic value of metastatic lymph nodes in the mediastinum among patients with left upper lung cancer who underwent complete dissection of the superior mediastinal lymph node through a median sternotomy.
  • METHODS: Forty-four patients with left upper lobe cancer underwent extended radical mediastinal nodal dissection (ERD), all of whom were analyzed in this retrospective study.
  • Mediastinal nodal status was assessed according to the systems of Mountain/Dresler 7 and Naruke 8.
  • The clinicopathological records of each patient were examined for prognostic factors, including age, sex, histology, tumor size, c-N number, preoperative serum CEA level, metastatic stations and distribution of metastatic nodes according to Naruke's system 8.
  • The superior mediastinal lymph nodes which cannot be dissected through a left thoracotomy (bilateral #1 and #2, #3, right #3a, and right #4 according to Naruke's map 8 were defined as extra-superior mediastinal nodes for left lung cancer (ESMD).
  • RESULTS: Fourteen patients had one or more metastases to mediastinal lymph nodes, among whom the most common metastatic station was the aortic nodes: 71.4% had metastasis to #5 or #6 (57.1% to #5 and 50% to #6).
  • The next most common metastatic station was the left tracheobronchial nodes (42.8%).
  • Metastasis to the ESMD occurred in 7 of the 44 study subjects (16%), representing a 50% rate of occurrence (7/14) among those with mediastinal nodal involvement.
  • Univariate analysis found that CN factor and aortic nodal involvement (#5, #6) were significant predictive factors for ESMD metastasis.
  • Furthermore, ESMD metastasis was rare (5.8%) in the absence of aortic node metastasis.
  • The overall survival rate at 5 years was 50% among the patients without ESMD metastasis.
  • However, the survival rate was 32% at 3 years and 0% at 5 years among the seven patients with ESMD metastasis.
  • CONCLUSIONS: The aortic lymph node is the most common site of metastasis from left upper lobe cancer.
  • Multivariate analysis demonstrated that aortic nodal involvement was a significant predictive factor for ESMD metastasis.
  • Based upon the rates of metastasis and the post-operative prognosis in our study patients, dissection of aortic nodes and left tracheobronchial nodes may be important for patients with left upper lobe cancer.
  • [MeSH-major] Lung Neoplasms / pathology. Mediastinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Aorta / pathology. Bronchial Neoplasms / pathology. Bronchial Neoplasms / secondary. Dissection / methods. Female. Humans. Lymphatic Metastasis. Male. Mediastinum / pathology. Mediastinum / surgery. Middle Aged. Prognosis. Retrospective Studies. Sternum / surgery. Survival Analysis. Thoracic Surgical Procedures. Tracheal Neoplasms / pathology. Tracheal Neoplasms / secondary

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  • (PMID = 16870462.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Germany
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60. Kesler KA, Wilson JL, Cosgrove JA, Brooks JA, Messiha A, Fineberg NS, Einhorn LH, Brown JW: Surgical salvage therapy for malignant intrathoracic metastases from nonseminomatous germ cell cancer of testicular origin: analysis of a single-institution experience. J Thorac Cardiovasc Surg; 2005 Aug;130(2):408-15
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  • [Title] Surgical salvage therapy for malignant intrathoracic metastases from nonseminomatous germ cell cancer of testicular origin: analysis of a single-institution experience.
  • BACKGROUND: Cisplatin-based chemotherapy followed by surgical extirpation of residual benign disease represents the usual sequence of curative therapy for metastatic nonseminomatous germ cell cancer of testicular origin.
  • Occasionally, residual disease is malignant in the form of either a persistent nonseminomatous germ cell cancer tumor or degeneration into non-germ cell cancer.
  • We reviewed our institution's experience with patients undergoing salvage operations to remove malignant intrathoracic metastases.
  • METHODS: From 1981 through 2001, 438 patients with nonseminomatous germ cell cancer had operations to remove residual intrathoracic disease after cisplatin-based chemotherapy at Indiana University Hospital.
  • A subset of 134 patients who underwent 186 surgical procedures to remove malignant metastases is the basis of this review.
  • Fifty-nine patients had removal of pulmonary metastases, 49 had removal of mediastinal metastases, and 26 had removal of both pulmonary and mediastinal metastases.
  • Surgical pathology demonstrated 84 patients with persistent nonseminomatous germ cell cancer tumors, 38 with degeneration into non-germ cell cancer, and 12 with both malignant pathologic categories.
  • Of these, older age, pulmonary metastases (vs mediastinal metastases), and 4 or more (vs 1) total intrathoracic metastases were significantly (P < or = .01) predictive of inferior long-term survival.
  • CONCLUSIONS: Salvage thoracic surgery to remove malignant metastases from nonseminomatous germ cell cancer tumors of testicular origin can result in long-term survival in select patients.
  • [MeSH-major] Lung Neoplasms / therapy. Mediastinal Neoplasms / therapy. Neoplasms, Germ Cell and Embryonal / therapy. Testicular Neoplasms / therapy. Thoracic Surgical Procedures / methods
  • [MeSH-minor] Adolescent. Adult. Antineoplastic Agents / therapeutic use. Cisplatin / therapeutic use. Combined Modality Therapy. Follow-Up Studies. Humans. Male. Middle Aged. Neoplasm Staging. Survival Analysis. Treatment Outcome

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  • (PMID = 16077406.001).
  • [ISSN] 0022-5223
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Antineoplastic Agents; Q20Q21Q62J / Cisplatin
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61. Pozo-Rodríguez F, Martín de Nicolás JL, Sánchez-Nistal MA, Maldonado A, García de Barajas S, Calero-García R, Pozo MA, Martín-Escribano P, Martín-García I, García-Lujan R, Lopez-Encuentra A, Arenas de Pablo A: Accuracy of helical computed tomography and [18F] fluorodeoxyglucose positron emission tomography for identifying lymph node mediastinal metastases in potentially resectable non-small-cell lung cancer. J Clin Oncol; 2005 Nov 20;23(33):8348-56
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  • [Title] Accuracy of helical computed tomography and [18F] fluorodeoxyglucose positron emission tomography for identifying lymph node mediastinal metastases in potentially resectable non-small-cell lung cancer.
  • PURPOSE: Computed tomography (CT) and [18F] Fluorodeoxyglucose positron emission tomography (FDG-PET) are considered suitable methods for the noninvasive staging of the mediastinum.
  • Our study was intended to estimate the efficacy of contrast-enhanced helical CT (hCT) and FDG-PET, alone and combined, in the diagnosis of lymph node mediastinal metastases.
  • METHODS: This study was a prospective and blind comparison of the efficacy of hCT and FDG-PET with two alternative reference standards, mediastinoscopy, and mediastinoscopy plus thoracotomy plus a 6-month follow-up to diagnose lymph node mediastinal metastases in 132 consecutive patients with potentially resectable non-small-cell lung cancer (NSCLC).
  • The metastatic disease was assessed histopathologically.
  • CONCLUSION: hCT and PET perform similarly in the mediastinal staging of NSCLC, both tests are conditionally dependent and provide complementary information, and their diagnostic value mainly resides on the negative results.
  • [MeSH-minor] Aged. Female. Fluorodeoxyglucose F18. Humans. Lymphatic Metastasis. Male. Mediastinum. Observer Variation. Predictive Value of Tests. Prospective Studies. Radiopharmaceuticals. Sensitivity and Specificity. Single-Blind Method

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  • [CommentIn] J Clin Oncol. 2005 Nov 20;23(33):8283-5 [16219928.001]
  • (PMID = 16219937.001).
  • [ISSN] 0732-183X
  • [Journal-full-title] Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • [ISO-abbreviation] J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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62. Shen-Tu Y, Zhao T, Ding Z, Zhou Y: [The prognostic value of detection of serum VEGF-C level and lymphangiogenesis in mediastinal lymph nodes in the patients with lung cancer.]. Zhongguo Fei Ai Za Zhi; 2008 Dec 20;11(6):769-74

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  • [Title] [The prognostic value of detection of serum VEGF-C level and lymphangiogenesis in mediastinal lymph nodes in the patients with lung cancer.].
  • BACKGROUND: There is still lack of special prognostic factor on lung cancer, this study will explore the prognostic value of serum VEGF-C level and lymphangiogenesis of primary cancer and mediastinal lymph nodes in the patients with lung cancer.
  • The VEGF-C and LYVE-1 expression in the mediastinal lymph nodes were put in practice between two groups.
  • The relationship was analyzed for the serum VEGF-C level, VEGF-C and LYVE-1 expression of primary cancer and mediastinal lymph nodes, mediastinal lymph nodes metastasis and the 3-year survival rate of the patients.
  • RESULTS: (1)In new group, the serum VEGF-C level of N2 patients was significantly higher than that of non-N2 patients. (2)In new group, the serum VEGF-C level was closely correlated with VEGF-C expression of primary cancer. (3)In two groups, the primary cancer and mediastinal metastasis lymph nodes had high VEGF-C expression. (4)VEGF-C expression of primary cancer and mediastinal lymph nodes was closely correlated with LYVE-1 expression between the two groups. (5)VEGF-C and LYVE-1 expression of N2 patients was significantly higher than that of non-N2 patients between two groups. (6)The patients' 3-year-survival rate was closely correlated with VEGF-C expression of primary cancer and mediastinal lymph nodes metastasis.
  • CONCLUSIONS: Serum VEGF-C level has close correlation with VEGF-C expression of primary cancer, lymphangiogenesis of primary cancer/mediastinal lymph nodes, mediastinal lymph nodes metastasis status and patient's survival rate.
  • Serum VEGF-C level is possible to be used as prognostic factor on lung cancer.

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  • (PMID = 20797326.001).
  • [ISSN] 1999-6187
  • [Journal-full-title] Zhongguo fei ai za zhi = Chinese journal of lung cancer
  • [ISO-abbreviation] Zhongguo Fei Ai Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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63. Hwangbo B, Lee HS, Lee GK, Lim KY, Lee SH, Kim HY, Lee JY, Zo JI: Transoesophageal needle aspiration using a convex probe ultrasonic bronchoscope. Respirology; 2009 Aug;14(6):843-9
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  • Of the 89 lesions, 39 malignant lesions were confirmed by EUS-B-FNA.
  • EUS-B-FNA provided additional diagnostic gain to bronchoscopic procedures in 16 patients (19.0%): 3 lung cancers were upstaged, 11 lung cancers were pathologically confirmed, and 2 patients were diagnosed with mediastinal metastasis from an extrathoracic malignancy.
  • This gain was obtained by the sampling of inaccessible (n = 4) or difficult lesions by endobronchial ultrasound-guided transbronchial needle aspiration (n = 2) or when bronchoscopy was difficult due to dyspnoea, cough, brain metastasis or other conditions (n = 10).

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  • (PMID = 19659830.001).
  • [ISSN] 1440-1843
  • [Journal-full-title] Respirology (Carlton, Vic.)
  • [ISO-abbreviation] Respirology
  • [Language] eng
  • [Publication-type] Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Australia
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64. Wang SY, Ye X, Ou W, Lin YB, Zhang BB, Yang H: Risk of cerebral metastases for postoperative locally advanced non-small-cell lung cancer. Lung Cancer; 2009 May;64(2):238-43
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  • [Title] Risk of cerebral metastases for postoperative locally advanced non-small-cell lung cancer.
  • BACKGROUND: Cerebral metastases are the main determining factor in the failure of locally advanced non-small-cell lung cancer (NSCLC) management.
  • Our study assessed the risk factors of brain metastases in patients with postoperative, locally advanced NSCLC.
  • METHODS: Two hundred twenty-three patients treated with surgical resection for stage III-N2 NSCLC were retrospective analyzed to elucidate risk factors for development of brain metastases, and to establish a mathematical model.
  • Frequency of brain metastases in the entire patient population was 38.1% (85/223).
  • Frequency of brain metastases in patients with single mediastinal lymph-node region with metastases at 1, 2, and 3 years was 5.6%, 14.0%, and 19.0%, respectively.
  • The frequency of brain metastases in patients with multiple mediastinal lymph-node regions with metastases was 31.8%, 60.3%, 68.0%, respectively (P<0.001).
  • The frequency of brain metastases among patients with mediastinal metastasis number less than 4, 4-6, and more than 6 was significantly different (P<0.001).
  • There were also significant differences in brain metastases frequency between patients with complete versus incomplete resection (P=0.001), and patients with non-squmous versus squamous (P=0.029), and patients administered adjuvant chemotherapy versus none (P=0.032).
  • CONCLUSION: A mathematical model to predict brain metastases risk was developed.
  • [MeSH-major] Brain Neoplasms / secondary. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Models, Theoretical
  • [MeSH-minor] Adult. Aged. Antineoplastic Agents / therapeutic use. Combined Modality Therapy. Female. Humans. Kaplan-Meier Estimate. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Pneumonectomy. Retrospective Studies. Risk Factors. Sensitivity and Specificity

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  • (PMID = 18838190.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Antineoplastic Agents
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65. Peccatori J, Barkholt L, Demirer T, Sormani MP, Bruzzi P, Ciceri F, Zambelli A, Da Prada GA, Pedrazzoli P, Siena S, Massenkeil G, Martino R, Lenhoff S, Corradini P, Rosti G, Ringden O, Bregni M, Niederwieser D, European Bone Marrow Transplantation Solid Tumor Working Party: Prognostic factors for survival in patients with advanced renal cell carcinoma undergoing nonmyeloablative allogeneic stem cell transplantation. Cancer; 2005 Nov 15;104(10):2099-103
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  • RESULTS: Factors that were found to be associated significantly with limited survival were performance status, the number of metastatic sites, the presence of mediastinal metastasis, hemoglobin level, C-reactive protein (CRP) level, lactate dehydrogenase (LDH) level, and neutrophil counts.

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  • [Copyright] Copyright 2005 American Cancer Society
  • (PMID = 16220555.001).
  • [ISSN] 0008-543X
  • [Journal-full-title] Cancer
  • [ISO-abbreviation] Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
  • [Chemical-registry-number] 9007-41-4 / C-Reactive Protein; EC 1.1.1.27 / L-Lactate Dehydrogenase
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66. Cremades A, Tériitéhau C, Grand B, Saint-Blancard P: [Late mediastinal metastasis of Ewing's sarcoma of tibia]. Rev Pneumol Clin; 2008 Jun;64(3):133-6
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  • [Title] [Late mediastinal metastasis of Ewing's sarcoma of tibia].
  • [Transliterated title] Métastase médiastinale tardive d'un sarcome d'Ewing du tibia.
  • Their metastatic potential is high, generally early, and rarely after five years.
  • We report the case of a 45-year-old woman who presented a mediastinal metastasis eight years after the primitive tumor of tibia.
  • The diagnosis was made on small core biopsies obtained by CT punction, and was based on morphologic analysis, immunohistochemistry, and confirmed by molecular biology.
  • The presence of metastasis is the main prognostic factor.
  • Despite therapeutic progress, the global survival rate of metastatic patients is still poor.
  • [MeSH-major] Bone Neoplasms / pathology. Mediastinal Neoplasms / diagnosis. Mediastinal Neoplasms / secondary. Sarcoma, Ewing / diagnosis. Sarcoma, Ewing / secondary. Tibia
  • [MeSH-minor] Diagnosis, Differential. Female. Humans. Middle Aged. Prognosis

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  • (PMID = 18656786.001).
  • [ISSN] 0761-8417
  • [Journal-full-title] Revue de pneumologie clinique
  • [ISO-abbreviation] Rev Pneumol Clin
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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67. Whitson BA, Groth SS, Andrade RS, Garrett L, Dudek AZ, Jessurun J, Maddaus MA: Extension of survival by resection of asynchronous renal cell carcinoma metastases to mediastinal lymph nodes. J Thorac Cardiovasc Surg; 2008 May;135(5):1022-8
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  • [Title] Extension of survival by resection of asynchronous renal cell carcinoma metastases to mediastinal lymph nodes.
  • OBJECTIVE: The aim of this study was to determine whether or not resection of isolated mediastinal lymph node renal cell carcinoma metastases confers a survival advantage, as compared with patients with stage IV disease.
  • Using Kaplan-Meier estimates, we compared the survival of patients who underwent resection of asynchronous mediastinal lymph node metastases with that of patients with stage IV disease.
  • RESULTS: During the 7-year study period, of the 386 patients with renal cell carcinoma who were evaluated at our institution, 9 underwent resection of asynchronous mediastinal lymph node metastases.
  • After primary tumor resection and before diagnosis of asynchronous mediastinal lymph node metastases, all patients completed chemotherapy, cytokine therapy, or tumor vaccination; 3 underwent radiotherapy.
  • The median age at resection of mediastinal lymph nodes was 57.7 years (range, 39.7-81.2).
  • The median time from primary tumor resection to mediastinal lymph node resection was 2.8 years (range, 0.5-23.3).
  • In all, 4 patients underwent resection of metastases via thoracotomy and 5, via thoracoscopy.
  • The median number of mediastinal lymph nodes pathologically evaluated was 7 (range, 2-28); the median number of positive mediastinal lymph nodes per patient was 1.5 (range, 1-3).
  • The median survival after resection of metastases (3.2 years) was significantly longer (P = .021) than for other patients with stage IV disease at our institution (1.1 years).
  • CONCLUSIONS: Resection of renal cell carcinoma mediastinal lymph node metastases is safe, appears to extend survival, and should be considered an important component of treating patients with renal cell carcinoma who have asynchronous mediastinal lymph node metastases.
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Neoplasm Staging. Retrospective Studies. Survival Analysis

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  • (PMID = 18455579.001).
  • [ISSN] 1097-685X
  • [Journal-full-title] The Journal of thoracic and cardiovascular surgery
  • [ISO-abbreviation] J. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] United States
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68. Shafazand S, Gould MK: A clinical prediction rule to estimate the probability of mediastinal metastasis in patients with non-small cell lung cancer. J Thorac Oncol; 2006 Nov;1(9):953-9
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  • [Title] A clinical prediction rule to estimate the probability of mediastinal metastasis in patients with non-small cell lung cancer.
  • INTRODUCTION: Estimating the clinical probability of mediastinal metastasis in patients with non-small cell lung cancer (NSCLC) can facilitate the selection and interpretation of staging tests.
  • PURPOSE: We sought to identify independent clinical predictors of mediastinal metastasis and to develop a prediction rule to estimate the pretest probability of nodal metastasis in patients with NSCLC.
  • Independent predictors of positive nodes included adenocarcinoma or large cell histology (OR 2.6, 95% confidence interval [CI] = 1.8-3.9), apparent metastatic disease on chest radiography (OR 2.4, 95% CI = 1.2-4.7), central location of the primary tumor (OR 2.1, 95% CI = 1.4-3.3), symptoms from the primary tumor (OR 1.6, 95% CI = 1.1-2.4), tumor diameter > or =3.6 cm (OR 1.5, 95% CI = 1.0-2.3), and age less than 65 years (OR 1.5, 95% CI = 1.0-2.2).
  • Model accuracy and calibration were good, with an area under the receiver operating characteristic curve of 0.70 (95% CI = 0.66-0.75) and good agreement between observed and predicted probabilities of mediastinal metastasis.
  • CONCLUSIONS: Our prediction rule can be used to estimate the pretest probability of mediastinal metastasis in patients with NSCLC.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Lymph Nodes / pathology. Mediastinal Neoplasms / secondary
  • [MeSH-minor] Age Factors. Aged. Biopsy, Needle. Confidence Intervals. Female. Humans. Immunohistochemistry. Male. Mediastinoscopy. Middle Aged. Neoplasm Staging. Odds Ratio. Predictive Value of Tests. Probability. Prognosis. Risk Assessment. Sex Factors. Survival Analysis. Treatment Outcome

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  • (PMID = 17409978.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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69. Zhi XY, Liu BD, Xu QS, Zhang Y, Su L, Wang HR, Hu M: [Clinical value of computed tomography and fluorine-18 fluorodeoxyglucose positron remission tomography in diagnosis of mediastinal metastasis of non small cell lung cancer]. Zhonghua Yi Xue Za Zhi; 2005 Aug 3;85(29):2026-9
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  • [Title] [Clinical value of computed tomography and fluorine-18 fluorodeoxyglucose positron remission tomography in diagnosis of mediastinal metastasis of non small cell lung cancer].
  • OBJECTIVE: To compare the clinical values of computed tomography (CT) and fluorine-18 fluorodeoxyglucose positron remission tomography (FDG-PET) in diagnosis of mediastinal metastasis of non-small cell lung cancer (NSCLC).
  • METHODS: Sixty patients with respectable NSCLC underwent CT and FDG-PET with an interval of 2 weeks and then underwent thoracotomy for clearance of the lymph nodes or biopsy of the mediastinal lymph nodes via mediastinoscopy.
  • The specimens of mediastinal lymph node underwent HE staining and PCNA/Ki67 immunohistochemical staining.
  • The sensitivity, specificity, accuracy, positive prediction value, and negative prediction value in diagnosis of metastasis of mediastinal lymph nodes of these 2 procedures were compared.
  • RESULTS: The sensitivity, specificity, accuracy, positive prediction value, and negative prediction value in diagnosis of metastasis of mediastinal lymph nodes were 92.3%, 87.5%, 91.2%, 96.0%, and 77.7% respectively for FDG-PET, and were 76.9%, 50.0%, 70.6%, 83.3%, and 40.0% respectively for CT.
  • CONCLUSION: PET is superior to CT in diagnosis of metastasis of NSCLC to mediastinal lymph nodes.
  • PET + CT significantly increases the sensitivity in diagnosis.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / diagnosis. Fluorodeoxyglucose F18. Lung Neoplasms / diagnosis. Lymph Nodes / pathology. Positron-Emission Tomography. Tomography, X-Ray Computed
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis. Male. Mediastinum. Middle Aged


70. Ichiki Y, Sugio K, Baba T, Mizukami M, Oga T, Takenoyama M, Hanagiri T, Okamoto K, Yamaguchi K, Katagiri S, Yamamoto M, Yasumoto K: Mediastinal metastasis from a fibrolamellar hepatocellular carcinoma: Report of a case. Surg Today; 2010 Apr;40(4):360-4
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  • [Title] Mediastinal metastasis from a fibrolamellar hepatocellular carcinoma: Report of a case.
  • This report presents a case of a rare mediastinal metastasis from FL-HCC in a patient who had undergone a previous resection for retroperitoneal metastasis after the initial hepatic operation.
  • This patient also had a mediastinal neurogenic tumor, and these mediastinal tumors were concurrently resected.
  • [MeSH-major] Carcinoma, Hepatocellular / pathology. Liver Neoplasms / pathology. Mediastinal Neoplasms / secondary
  • [MeSH-minor] Adult. Humans. Male. Retroperitoneal Neoplasms / secondary

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  • (PMID = 20339991.001).
  • [ISSN] 1436-2813
  • [Journal-full-title] Surgery today
  • [ISO-abbreviation] Surg. Today
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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71. Hashimoto H, Oshika Y, Takeshima S, Edogawa S, Takeo H, Sato K, Tanaka Y: [Peripheral small squamous cell carcinoma (9 mm) of the lung with metastasis to mediastinal lymph nodes]. Kyobu Geka; 2007 Dec;60(13):1167-70
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  • [Title] [Peripheral small squamous cell carcinoma (9 mm) of the lung with metastasis to mediastinal lymph nodes].
  • A 61-year-old man was pointed out a small peripheral lung nodule and mediastinal lymph node swelling on the chest computed tomography (CT).
  • The tumor was 9 mm in size and diagnosed as well differentiated squamous cell carcinoma with metastasis to mediastinal lymph nodes.
  • We reported a case of peripheral small squamous cell carcinoma (9 mm) of the lung with metastasis to mediastinal lymph nodes.
  • [MeSH-major] Carcinoma, Squamous Cell / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology. Lymphatic Metastasis / pathology

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  • (PMID = 18078084.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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72. Bruglia M, Palmonella G, Silvetti F, Rutigliano P, Criante P, Marmorale C, Boscaro M, Taccaliti A: Skin and thigh muscle metastasis from papillary thyroid cancer. Singapore Med J; 2009 Feb;50(2):e61-4
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  • [Title] Skin and thigh muscle metastasis from papillary thyroid cancer.
  • A 44-year-old man with total thyroidectomy for papillary thyroid carcinoma (PTC) performed at the age of 38 years was referred for mediastinal metastases demonstrated on chest radiograph and high serum thyroglobulin (Tg 328 ng/ml).
  • Computed tomography revealed mediastinal lymph node enlargement with left bronchial compression and reduction of bronchial diameter, as well as two metastases in the left lung.
  • External beam radiotherapy and chemotherapy yielded no benefit; the neoplasm was aggressive, diffuse and experienced fast growth, leading to the formation of metastases also at unusual sites, such as the skin and thigh muscle.
  • The patient died from a brain metastasis.
  • We report a rare case of PTC metastasis with a poorly-differentiated component in a young patient.
  • Rapid and diffuse metastases also to unusual sites led to death eight years after the initial diagnosis and treatment.
  • [MeSH-major] Carcinoma, Papillary / diagnosis. Carcinoma, Papillary / pathology. Muscle, Skeletal / pathology. Skin Neoplasms / secondary. Thyroid Neoplasms / diagnosis. Thyroid Neoplasms / pathology
  • [MeSH-minor] Adult. Biopsy. Fatal Outcome. Humans. Lung Neoplasms / secondary. Male. Mediastinal Neoplasms / secondary. Neoplasm Metastasis. Radiotherapy / methods. Thigh / pathology. Thyroglobulin / blood


73. Chen QK, Ding JA, Gao W, Zhu YM: [Skip metastasis to mediastinal lymph nodes: clinical significance and prognosis in stage III non-small cell lung cancer]. Zhonghua Jie He He Hu Xi Za Zhi; 2005 Jul;28(7):472-4
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  • [Title] [Skip metastasis to mediastinal lymph nodes: clinical significance and prognosis in stage III non-small cell lung cancer].
  • OBJECTIVE: To analyze the significance and prognosis of skip metastasis to mediastinal lymph nodes in stage III non-small cell lung cancer (NSCLC).
  • Twenty-one of these patients (32.3%), showing no metastatic involvement of hilar (N(1)) lymph nodes, were compared to the remaining 44 patients with infiltration of hilar nodes (N(1)) as well as N(2) nodes.
  • RESULTS: Multivariate analysis showed no statistically significant difference between the skip metastasis and the continuous N(2) group regarding sex, age, histology, location, and T-or M-status.
  • In the skip metastasis group, mediastinal node metastasis was found in >or=2 region in 16 patients (36.4%) and in continuous N(2) group in 2 patients (9.5%, chi(2) = 8.571, P = 0.036).
  • The 5-year survival rate of pN(2) patients with skip metastasis was 41% compared to 21% in patients with involvement of N(1) and N(2) nodes (P = 0.022 6), and the mean survival time was 44 months and 26 months respectively.
  • CONCLUSIONS: pN(2) patients with mediastinal lymph node skip metastasis have a more favorable prognosis compared to pN(2) patients with continuous infiltration of the regional lymph nodes.
  • Skip metastasis is an independent prognostic factor for survival.
  • Skip metastasis may represent a subgroup of pN(2) classification.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Lung Neoplasms / pathology. Lymph Nodes / pathology. Mediastinal Neoplasms / secondary
  • [MeSH-minor] Aged. Female. Humans. Lymphatic Metastasis / pathology. Male. Middle Aged. Neoplasm Staging. Prognosis. Survival Rate

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  • (PMID = 16115397.001).
  • [ISSN] 1001-0939
  • [Journal-full-title] Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
  • [ISO-abbreviation] Zhonghua Jie He He Hu Xi Za Zhi
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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74. Dagli AF, Pehlivan S, Cihangiroglu G, Ozercan MR: Cytology of mixed germ cell tumor with mediastinal metastasis. J Cytol; 2009 Jul;26(3):120-2
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  • [Title] Cytology of mixed germ cell tumor with mediastinal metastasis.
  • Nonseminomatous germ cell tumors of the testis are common and are very aggressive malignant tumors.
  • Most of the cases have metastases at the time of diagnosis, and involvement of the posterior mediastinum in particular is well known.
  • His thoracic computed tomography (CT) showed a 1.5 cm lymph node on the anterior mediastinum and a mass of about 11 × 10 × 8 cm extending from the right lung apex to the right hilus, with regular contours and without contrast enhancement.
  • The patient, who was given the preliminary diagnosis of a mixture metastatic bronchial tumor plus lymphoma, was subjected to transthoracic fine needle aspiration cytology (FNAC).
  • The patient, who could not be typed in his cytopathological examination, was diagnosed with malignant epithelial tumor and was recommended to undergo a genitourinary system examination.
  • Histopathological examination of the orchiectomy material resulted in the diagnosis of mixed germ cell tumor (60% mature teratoma and 40% yolk sac tumor).
  • Even though metastatic lesions are mostly seen in the posterior mediastinum, our findings reveal that specimens obtained with FNAC from the anterior mediastinum bear discohesive, pleomorphic, small nuclei in epithelial cells with microvacoules in the cytoplasm.
  • These cytopathological alterations in specimens from the anterior mediastinum might promote germ cell and yolk sac tumors.

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  • (PMID = 21938171.001).
  • [ISSN] 0970-9371
  • [Journal-full-title] Journal of cytology
  • [ISO-abbreviation] J Cytol
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] India
  • [Other-IDs] NLM/ PMC3168014
  • [Keywords] NOTNLM ; Nonseminomatous germ cell tumor / fine needle aspiration cytology / mixed germ cell tumor / testis
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75. Hwangbo B, Kim SK, Lee HS, Lee HS, Kim MS, Lee JM, Kim HY, Lee GK, Nam BH, Zo JI: Application of endobronchial ultrasound-guided transbronchial needle aspiration following integrated PET/CT in mediastinal staging of potentially operable non-small cell lung cancer. Chest; 2009 May;135(5):1280-7
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  • [Title] Application of endobronchial ultrasound-guided transbronchial needle aspiration following integrated PET/CT in mediastinal staging of potentially operable non-small cell lung cancer.
  • BACKGROUND: The role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) following integrated PET/CT scanning in mediastinal staging of non-small cell lung cancer (NSCLC) has not been assessed.
  • METHODS: We prospectively evaluated the diagnostic values of PET/CT scanning and EBUS-TBNA for mediastinal staging in 117 patients with potentially operable NSCLC with accessible mediastinal lymph nodes (diameter range, 5 to 20 mm) by EBUS-TBNA.
  • RESULTS: Of 30 cases of mediastinal metastasis, 27 were confirmed by EBUS-TBNA and 3 were confirmed by surgery.
  • The sensitivity, specificity, positive predictive value, negative predictive value (NPV), and accuracy of EBUS-TBNA in the detection of mediastinal metastasis were 90.0%, 100%, 100%, 96.7%, and 97.4%, respectively.
  • CONCLUSIONS: EBUS-TBNA was an effective invasive method following PET/CT scanning in the mediastinal staging of potentially operable NSCLC.
  • In mediastinal PET/CT scan-positive cases, EBUS-TBNA was an excellent tool for detecting mediastinal metastasis.
  • Even in mediastinal PET/CT scan-negative cases, EBUS-TBNA can be useful for confirming mediastinal metastases, especially in adenocarcinoma.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / secondary. Carcinoma, Non-Small-Cell Lung / ultrasonography. Lung Neoplasms / pathology. Mediastinal Neoplasms / secondary. Mediastinal Neoplasms / ultrasonography
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adenocarcinoma / ultrasonography. Adult. Aged. Aged, 80 and over. Biopsy, Needle / methods. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Carcinoma, Squamous Cell / ultrasonography. Endosonography. Female. Humans. Male. Middle Aged. Neoplasm Staging. Positron-Emission Tomography. Prospective Studies. Thoracoscopy / methods. Tomography, X-Ray Computed

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  • (PMID = 19118267.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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76. Subiger L, Breton JL, Poulin G: [Iris metastasis of bronchial carcinoma: a case report]. J Fr Ophtalmol; 2008 May;31(5):527-32
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  • [Title] [Iris metastasis of bronchial carcinoma: a case report].
  • [Transliterated title] Métastase de l'iris d'un adénocarcinome bronchique: à propos d'un cas.
  • The patient presented a left iridal metastasis of bronchial carcinoma, a left frontal cerebral metastasis, and mediastinal evolutionary recovery.
  • The patient died 10 months after the ocular metastasis diagnosis.
  • In the event of iridal metastasis, it is necessary to carry out a complete examination of both eyes, to question the patient, to search for a primary tumor and other metastases, and to rapidly implement radiotherapy of the entire ocular sphere (30 Gy in ten fractions).
  • [MeSH-major] Adenocarcinoma / pathology. Bronchial Neoplasms / pathology. Iris Neoplasms / secondary. Neoplasm Metastasis / pathology

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  • (PMID = 18641587.001).
  • [ISSN] 1773-0597
  • [Journal-full-title] Journal français d'ophtalmologie
  • [ISO-abbreviation] J Fr Ophtalmol
  • [Language] fre
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] France
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77. Pan TC, Zheng Z, Li J, Chen T, Liu LG, Wei X: [Appropriate extent of lymph node dissection for clinical I a stage non-small cell lung cancer]. Ai Zheng; 2007 Mar;26(3):303-6
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  • [Title] [Appropriate extent of lymph node dissection for clinical I a stage non-small cell lung cancer].
  • BACKGROUND & OBJECTIVE: There is no agreement on the appropriate extent of lymph node dissection for lung cancer, especially for early non-small cell lung cancer (NSCLC).
  • This study was to explore the appropriate extent of lymph node dissection for early NSCLC by investigating the metastasis regulations of hilar and mediastinal lymph nodes.
  • METHODS: Forty-one clinical Ia stage NSCLC patients received lobectomy and systematic mediastinal lymphadenectomy in Tongji Hospital from Jan.
  • The metastasis regulations of hilar and mediastinal lymph nodes were investigated.
  • Among them, 42 (14.2%) groups had metastasis, including 33 groups of hilar lymph nodes and 9 of mediastinal lymph nodes.
  • Four patients had mediastinal lymph node metastasis in the 7th station, 2 in the 5th station, 2 in the 9th station, and 1 in the 4th station.
  • The patients with tumors in the upper lobe had metastasis in the 5th or 7th station lymph nodes; the patients with tumors in the middle or lower lobe had metastasis in the 4th, 7th, or 9th station.
  • CONCLUSIONS: The metastasis regulations of hilar and mediastinal lymph nodes in Ia stage NSCLC is accordant to regional lymph node drainage regulations.
  • Selective regional lymph node dissection might be applied in these patients, that is, upper mediastinal lymph node, not lower mediastinal lymph node, should be removed when the tumor is in the upper lobe without hilar or subcarinal lymph node metastasis, while all mediastinal lymph nodes should be removed when the tumor is in the middle or lower lobe.
  • [MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / surgery. Adult. Aged. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / surgery. Female. Follow-Up Studies. Humans. Lung / pathology. Lymph Nodes / surgery. Lymphatic Metastasis. Male. Mediastinum / pathology. Mediastinum / surgery. Middle Aged. Neoplasm Staging. Pneumonectomy / methods. Survival Rate


78. Micames CG, McCrory DC, Pavey DA, Jowell PS, Gress FG: Endoscopic ultrasound-guided fine-needle aspiration for non-small cell lung cancer staging: A systematic review and metaanalysis. Chest; 2007 Feb;131(2):539-48
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  • [Title] Endoscopic ultrasound-guided fine-needle aspiration for non-small cell lung cancer staging: A systematic review and metaanalysis.
  • BACKGROUND: Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is a minimally invasive alternative technique for mediastinal staging of non-small cell lung cancer.
  • A metaanalysis was performed to estimate the diagnostic accuracy of EUS-FNA for staging mediastinal lymph nodes (N2/N3 disease) in patients with lung cancer.
  • RESULTS: In 18 eligible studies, EUS-FNA identified 83% of patients (95% confidence interval [CI], 78 to 87%) with positive mediastinal lymph nodes (pooled sensitivity) and 97% of patients (95% CI, 96 to 98%) with negative mediastinal lymph nodes (pooled specificity).
  • In eight studies that were limited to patients who had abnormal mediastinal lymph nodes seen on CT scans, the sensitivity was 90% (95% CI, 84 to 94%) and the specificity was 97% (95% CI, 95 to 98%).
  • In patients without abnormal mediastinal lymph nodes seen on CT scans (four studies), the pooled sensitivity was 58% (95% CI, 39 to 75%).
  • CONCLUSIONS: EUS-FNA is a safe modality for the invasive staging of lung cancer that is highly sensitive when used to confirm metastasis to mediastinal lymph nodes seen on CT scans.
  • In addition, among lung cancer patients with normal mediastinal adenopathy seen on CT scans, despite lower sensitivity, it has the potential to prevent unnecessary surgery in a large proportion of cases missed by CT scanning.
  • [MeSH-major] Biopsy, Fine-Needle. Carcinoma, Non-Small-Cell Lung / pathology. Endosonography. Lung Neoplasms / pathology. Neoplasm Staging / methods. Surgery, Computer-Assisted


79. Kanzaki R, Higashiyama M, Okami J, Kodama K: Surgical treatment for patients with solitary metastasis in the mediastinal lymph node from renal cell carcinoma. Interact Cardiovasc Thorac Surg; 2009 Apr;8(4):485-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Surgical treatment for patients with solitary metastasis in the mediastinal lymph node from renal cell carcinoma.
  • We performed surgical treatment on two patients, each with a solitary metastasis in a mediastinal lymph node from a renal cell carcinoma (RCC).
  • The first case was a 58-year-old male with a chief complaint of chest discomfort due to pretracheal mediastinal lymph node (#3) swelling.
  • Because of difficulty in establishing the diagnosis, a mini-thoracotomy was performed, and this lymphadenopathy was judged to be metastasis from the RCC.
  • This swollen lymph node was resected, and it was finally diagnosed to be metastasis from the RCC.
  • Unfortunately, the tumor recurred in the mediastinal lymph nodes with multiple lung metastases five years later.
  • A solitary metastasis in a mediastinal lymph node from a RCC is an unusual event, particularly in the absence of lung metastasis.
  • [MeSH-minor] Female. Humans. Lung Neoplasms / secondary. Lymphatic Metastasis. Male. Mediastinum. Middle Aged. Nephrectomy. Tomography, X-Ray Computed. Treatment Outcome

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  • (PMID = 19126555.001).
  • [ISSN] 1569-9285
  • [Journal-full-title] Interactive cardiovascular and thoracic surgery
  • [ISO-abbreviation] Interact Cardiovasc Thorac Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] England
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80. Herth FJ, Rabe KF, Gasparini S, Annema JT: Transbronchial and transoesophageal (ultrasound-guided) needle aspirations for the analysis of mediastinal lesions. Eur Respir J; 2006 Dec;28(6):1264-75
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transbronchial and transoesophageal (ultrasound-guided) needle aspirations for the analysis of mediastinal lesions.
  • A tissue diagnosis of mediastinal nodes is frequently needed for accurate lung cancer staging as well as the assessment of mediastinal masses.
  • Provided mediastinal metastases are confirmed, TBNA has a high impact on patient management.
  • Mediastinal lymph nodes located adjacent to the oesophagus can be assessed by transoesophageal ultrasound-guided fine needle aspiration (EUS-FNA).
  • Owing to the complementary reach of EBUS-TBNA and EUS-FNA in assessing different regions of the mediastinum, recent studies suggest that complete and accurate mediastinal staging can be achieved by the combination of both procedures.
  • It is expected that implementation of minimally invasive endoscopic methods of endobronchial ultrasound-guided transbronchial needle aspiration and transoesophageal ultrasound-guided fine needle aspiration will reduce the need for surgical staging of lung cancer significantly.
  • [MeSH-major] Biopsy, Fine-Needle. Bronchoscopy. Endosonography. Mediastinal Diseases / diagnosis

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  • (PMID = 17138681.001).
  • [ISSN] 0903-1936
  • [Journal-full-title] The European respiratory journal
  • [ISO-abbreviation] Eur. Respir. J.
  • [Language] eng
  • [Publication-type] Meta-Analysis
  • [Publication-country] Switzerland
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81. Hwangbo B, Lee GK, Lee HS, Lim KY, Lee SH, Kim HY, Lee HS, Kim MS, Lee JM, Nam BH, Zo JI: Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer. Chest; 2010 Oct;138(4):795-802
ClinicalTrials.gov. clinical trials - ClinicalTrials.gov .

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transbronchial and transesophageal fine-needle aspiration using an ultrasound bronchoscope in mediastinal staging of potentially operable lung cancer.
  • OBJECTIVE: We performed this study to evaluate the role of transesophageal endoscopic ultrasound with bronchoscope-guided fine-needle aspiration (EUS-B-FNA) following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the mediastinal staging of lung cancer.
  • METHODS: In this prospective study, we applied transbronchial and transesophageal ultrasonography using an ultrasound bronchoscope on patients with confirmed or strongly suspected potentially operable non-small cell lung cancer.
  • Following EBUS-TBNA, EUS-B-FNA was used for mediastinal nodes that were inaccessible or difficult to access by EBUS-TBNA.
  • The accessibility by EBUS-TBNA and EUS-B-FNA to mediastinal nodal stations having at least one node ≥ 5 mm was also checked.
  • RESULTS: In 150 patients, we performed EBUS-TBNA and EUS-B-FNA on 299 and 64 mediastinal nodal stations, respectively.
  • Among 143 evaluable patients, EBUS-TBNA diagnosed mediastinal metastasis in 38 patients.
  • EUS-B-FNA identified mediastinal metastasis in three additional patients.
  • Surgery diagnosed mediastinal metastasis in four more patients.
  • The sensitivity, negative predictive value, and diagnostic accuracy of EBUS-TBNA in the detection of mediastinal metastasis were 84.4%, 93.3%, and 95.1%, respectively.
  • Among 473 mediastinal nodal stations having at least one node ≥ 5 mm that were evaluated, the proportion of accessible mediastinal nodal stations by EBUS-TBNA was 78.6%, and the proportion increased to 84.8% by combining EUS-B-FNA with EBUS-TBNA (P = .015).
  • CONCLUSION: Following EBUS-TBNA in the mediastinal staging of potentially operable lung cancer, the accessibility to mediastinal nodal stations increased by adding EUS-B-FNA and an additional diagnostic gain might be obtained by EUS-B-FNA.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Bronchoscopy. Carcinoma, Non-Small-Cell Lung / pathology. Endosonography. Lung Neoplasms / pathology. Lymphatic Metastasis / pathology. Ultrasonography, Interventional
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Female. Humans. Male. Mediastinum. Middle Aged. Neoplasm Staging. Predictive Value of Tests. Prospective Studies. Sensitivity and Specificity. Sentinel Lymph Node Biopsy

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  • [CommentIn] Chest. 2010 Oct;138(4):765-7 [20923792.001]
  • [CommentIn] Chest. 2011 Jul;140(1):271-2; author reply 272-3 [21729906.001]
  • (PMID = 20348194.001).
  • [ISSN] 1931-3543
  • [Journal-full-title] Chest
  • [ISO-abbreviation] Chest
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00741247
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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82. Musallam KM, Taher AT, Tawil AN, Chakhachiro ZI, Habbal MZ, Shamseddine AI: Solitary mediastinal lymph node metastasis in rectosigmoid carcinoma: a case report. Cases J; 2008;1(1):69

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Solitary mediastinal lymph node metastasis in rectosigmoid carcinoma: a case report.
  • INTRODUCTION: Colorectal cancer most commonly metastasizes to the regional lymph nodes, liver, bone, lung, and brain.
  • Metastases to mediastinal lymph nodes is a rare entity which has never been reported to be solitary.
  • CASE REPORT: We herein describe a 67-year-old male patient with a solitary mediastinal lymph node metastasis three years following the resection of his primary rectosigmoid carcinoma.
  • Pathological characteristics of the metastatic tissue and technical limitations in imaging modalities resulted in incongruity between follow-up CT and PET scans.
  • Diagnosis of this distant metastasis has been confirmed through a mediastinoscopic biopsy.
  • CONCLUSION: Attention should be paid to the mediastinum when evaluating PET scan or CT films during follow-up of patients with colorectal cancer.

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  • [Cites] Surg Today. 1999;29(4):375-7 [10211574.001]
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  • (PMID = 18671857.001).
  • [ISSN] 1757-1626
  • [Journal-full-title] Cases journal
  • [ISO-abbreviation] Cases J
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC2515293
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83. Vilmann P, Krasnik M, Larsen SS, Jacobsen GK, Clementsen P: Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy: a combined approach in the evaluation of mediastinal lesions. Endoscopy; 2005 Sep;37(9):833-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy: a combined approach in the evaluation of mediastinal lesions.
  • BACKGROUND AND STUDY AIMS: It would be desirable to develop minimally invasive methods of tissue diagnosis from lymph nodes as well as solid lesions in the mediastinum.
  • The aim of the present study was to test the combined method of transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the evaluation of mediastinal lesions.
  • PATIENTS AND METHODS: EUS-FNA and EBUS-TBNA were compared in 33 patients, for the staging of lung cancer in patients with an established diagnosis of non-small-cell lung cancer (n = 20) or for diagnosis of a suspicious mediastinal lesion in patients with suspected lung cancer (n = 13).
  • EUS-FNA and EBUS-TBNA demonstrated cancer in 26 and 28 lesions, respectively, and benign cytology in 30 and 28 lesions, respectively.
  • When the 60 EBUS-TBNA samples were compared with the 59 EUS-FNA samples, 11 additional cancer diagnoses and three samples with suspicious cells were obtained by EBUS-TBNA that had not been obtained by EUS-FNA.
  • Conversely, EUS-FNA diagnosed 12 additional cancer diagnoses, one suspicious and one specific benign diagnosis (sarcoidosis) in addition to EBUS-TBNA.
  • With a combined approach (EUS-FNA + EBUS-TBNA) in 28 of the 31 patients in whom a final diagnosis was obtained in the evaluation of mediastinal cancer, 20 patients were found to have mediastinal involvement, whereas no mediastinal metastases were found in eight patients.
  • The accuracy of EUS-FNA and EBUS-TBNA, in combination, for the diagnosis of mediastinal cancer was 100 % (95 % CI, 83 - 100 %).
  • A combined approach with both EUS-FNA and EBUS-TBNA may be able to replace more invasive methods for evaluating lung cancer patients with suspected hilar or mediastinal metastases, as well as for evaluating unclear mediastinal or hilar lesions.
  • [MeSH-major] Biopsy, Fine-Needle / methods. Carcinoma, Non-Small-Cell Lung / pathology. Endosonography. Lung Neoplasms / pathology. Mediastinal Neoplasms / pathology. Mediastinal Neoplasms / secondary
  • [MeSH-minor] Adult. Aged. Bronchi. Esophagus. Female. Humans. Male. Middle Aged. Neoplasm Staging / methods

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  • (PMID = 16116534.001).
  • [ISSN] 0013-726X
  • [Journal-full-title] Endoscopy
  • [ISO-abbreviation] Endoscopy
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article
  • [Publication-country] Germany
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84. Holty JE, Kuschner WG, Gould MK: Accuracy of transbronchial needle aspiration for mediastinal staging of non-small cell lung cancer: a meta-analysis. Thorax; 2005 Nov;60(11):949-55
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accuracy of transbronchial needle aspiration for mediastinal staging of non-small cell lung cancer: a meta-analysis.
  • BACKGROUND: The reported accuracy of transbronchial needle aspiration (TBNA) for mediastinal staging in non-small cell lung cancer (NSCLC) varies widely.
  • We performed a meta-analysis to estimate the accuracy of TBNA for mediastinal staging in NSCLC.
  • RESULTS: Thirteen studies met inclusion criteria, including six studies that surgically confirmed all TBNA results and enrolled at least 10 patients with and without mediastinal metastasis (tier 1).
  • In tier 1 studies the median prevalence of mediastinal metastasis was 34%.
  • Compared with tier 1 studies, the median prevalence of mediastinal metastasis (81%; p = 0.002) and pooled sensitivity (78%; 95% CI 71 to 84; p = 0.009) were higher in non-tier 1 studies.
  • Sensitivity analysis confirmed that the sensitivity of TBNA depends critically on the prevalence of mediastinal metastasis.
  • CONCLUSIONS: When properly performed, TBNA is highly specific for identifying mediastinal metastasis in patients with NSCLC, but sensitivity depends critically on the study methods and patient population.
  • In populations with a lower prevalence of mediastinal metastasis, the sensitivity of TBNA is much lower than reported in recent lung cancer guidelines.
  • [MeSH-minor] Biopsy, Needle / standards. Humans. Middle Aged. Neoplasm Staging / standards. Sensitivity and Specificity


85. Wallace MB, Block MI, Gillanders W, Ravenel J, Hoffman BJ, Reed CE, Fraig M, Cole D, Mitas M: Accurate molecular detection of non-small cell lung cancer metastases in mediastinal lymph nodes sampled by endoscopic ultrasound-guided needle aspiration. Chest; 2005 Feb;127(2):430-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Accurate molecular detection of non-small cell lung cancer metastases in mediastinal lymph nodes sampled by endoscopic ultrasound-guided needle aspiration.
  • OBJECTIVES: The recurrence of disease after the complete resection of early stage non-small cell lung cancer (NSCLC) indicates that undetected metastases were present at the time of surgery.
  • Quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) is a highly sensitive technique for detecting rare gene transcripts that may indicate the presence of cancer cells, and endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is a minimally invasive technique for the nonoperative sampling of mediastinal lymph nodes.
  • The aim of this study was to determine whether these two techniques could enhance the preoperative detection of occult metastases.
  • Those patients without evidence of metastases (87 patients) underwent EUS-guided FNA.
  • Normal control FNA specimens were obtained from patients without cancer who were undergoing EUS for benign disease (17 control specimens).
  • For each sample, messenger RNA was extracted and real-time RT-PCR was used to quantitate the expression of six lung cancer-associated genes (ie, CEA, CK19, KS1/4, lunx, muc1, and PDEF) relative to the expression of an internal control gene (beta(2)-microglobulin).
  • Of the cytology-positive lymph nodes (27 lymph nodes), the expression of the KS1/4 gene was above its respective clinical threshold in 25 of 27 samples (93%), making this the most sensitive marker for the detection of metastatic NSCLC.
  • At least one of the six lung cancer-associated genes was overexpressed in 18 of 61 cytology-negative patients (30%), of which KS1/4 was overexpressed in 15 of 61 patients (25%).
  • Among the genes used in our marker panel, KS1/4 appears particularly useful for the detection of overt or occult metastatic disease.
  • [MeSH-major] Biomarkers, Tumor / genetics. Biopsy, Fine-Needle. Carcinoma, Non-Small-Cell Lung / genetics. Carcinoma, Non-Small-Cell Lung / pathology. Endosonography. Lung Neoplasms / genetics. Lymph Nodes / pathology. Transcription Factors / genetics


86. Renaud J, Yartsev S, Dar AR, Van Dyk J: Adaptive radiation therapy for localized mesothelioma with mediastinal metastasis using helical tomotherapy. Med Dosim; 2009;34(3):233-42
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  • [Title] Adaptive radiation therapy for localized mesothelioma with mediastinal metastasis using helical tomotherapy.
  • A patient having mesothelioma with mediastinal nodes was treated using helical tomotherapy with pretreatment megavoltage CT (MVCT) imaging.
  • Gross tumor volumes (GTVs) were outlined on every MVCT study.
  • [MeSH-major] Mediastinal Neoplasms / radiotherapy. Mediastinal Neoplasms / secondary. Mesothelioma / radiotherapy. Mesothelioma / secondary. Radiometry / methods. Radiotherapy Planning, Computer-Assisted / methods. Radiotherapy, Conformal / methods

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  • (PMID = 19647635.001).
  • [ISSN] 1873-4022
  • [Journal-full-title] Medical dosimetry : official journal of the American Association of Medical Dosimetrists
  • [ISO-abbreviation] Med Dosim
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] United States
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87. Nar Demirer A, Ayturk S, Tutuncu NB, Gursoy A, Pak Y, Demirag NG: Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy. Exp Clin Endocrinol Diabetes; 2009 Apr;117(4):155-8
Hazardous Substances Data Bank. PROPYL THIOURACIL .

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  • [Title] Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy.
  • Distant metastases as initial manifestation of follicular thyroid carcinoma is rare.
  • Computed tomography demonstrated a lobulated soft-tissue mass (17 x 11 x 6 cm) destructing sternum and extending into the anterior mediastinum.
  • There was no lung metastasis.
  • Invasion of tumor to the ascending aorta, superior vena cava, and right atrium could not be excluded.
  • Since there was huge tumor burden and iodinated contrast exposure for several times during evaluation, we decided to treat the patient with external beam radiotherapy (EBRT) rather than radioiodine as first-line therapy.
  • After a course of conventional radiation with 50 Gy in 25 fractions over 4 weeks, encompassing the thyroid bed and the gross disease, tumor regressed remarkably in 6 months.
  • The indications of EBRT for differentiated thyroid cancer still remain poorly defined.
  • [MeSH-major] Adenocarcinoma, Follicular / radiotherapy. Mediastinal Neoplasms / radiotherapy. Thoracic Neoplasms / radiotherapy. Thyroid Neoplasms / radiotherapy

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  • (PMID = 18561094.001).
  • [ISSN] 1439-3646
  • [Journal-full-title] Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • [ISO-abbreviation] Exp. Clin. Endocrinol. Diabetes
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Germany
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 721M9407IY / Propylthiouracil; Q51BO43MG4 / Thyroxine
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88. Katakura H, Sato M, Tanaka F, Sakai H, Bando T, Hasegawa S, Nakashima Y, Wada H: Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node. Ann Thorac Surg; 2005 Dec;80(6):2351-3
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  • [Title] Pulmonary sclerosing hemangioma with metastasis to the mediastinal lymph node.
  • Bronchoscopy revealed obstruction of the left B6c bronchus by a tumor, for which biopsy was done but no definitive histologic diagnosis could be made.
  • Then, left lower lobectomy was performed, and the tumor was diagnosed as a pulmonary sclerosing hemangioma.
  • A mediastinal lymph node (no. 7) showed some metastatic tumor cells.
  • As lymph node metastasis from pulmonary sclerosing hemangioma is very rare, we herein report the details of our case.
  • [MeSH-major] Pulmonary Sclerosing Hemangioma / secondary
  • [MeSH-minor] Adult. Humans. Lymphatic Metastasis. Male. Mediastinum

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  • (PMID = 16305908.001).
  • [ISSN] 1552-6259
  • [Journal-full-title] The Annals of thoracic surgery
  • [ISO-abbreviation] Ann. Thorac. Surg.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Netherlands
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89. Gotohda N, Nishimura M, Yoshida J, Nagai K, Tanaka N: The pattern of lymphatic metastases in superficial squamous cell carcinoma of the esophagus. Hepatogastroenterology; 2005 Jan-Feb;52(61):105-7
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] The pattern of lymphatic metastases in superficial squamous cell carcinoma of the esophagus.
  • We therefore analyzed patterns of lymph node metastasis in these patients.
  • RESULTS: Lymph node involvement was found in 0% (0/13) and 44% (23/52) of patients whose tumor invaded the muscularis mucosa and submucosal layer, respectively.
  • None of the patients with upper thoracic esophageal cancer had metastasis to the mediastinal and abdominal nodes.
  • Patients with lower thoracic esophageal tumors (Lt) had no metastasis to the cervical nodes.
  • Patients with middle thoracic esophageal tumors (Mt) and Lt patients rarely had metastasis (2-5%) in the lower mediasinal nodes (Nos. 108-112).
  • No patient with superficial thoracic esophageal cancer had metastasis to the subcarinal nodes in this study.
  • CONCLUSIONS: In our series, no patient with intramucosal carcinoma had lymphatic metastases.
  • In Mt and Lt patients, metastases to the mediastinal nodes were infrequent (2-7%).
  • Mediastinal nodes other than #107 can easily be sampled through cervical and abdominal incisions.
  • [MeSH-major] Carcinoma, Squamous Cell / secondary. Esophageal Neoplasms / pathology. Lymphatic Metastasis / pathology
  • [MeSH-minor] Abdomen / pathology. Adult. Aged. Esophagectomy. Female. Humans. Lymph Node Excision. Male. Mediastinum / pathology. Middle Aged. Neck / pathology. Retrospective Studies. Survival Rate

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  • (PMID = 15783006.001).
  • [ISSN] 0172-6390
  • [Journal-full-title] Hepato-gastroenterology
  • [ISO-abbreviation] Hepatogastroenterology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] Greece
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90. Zakowski MF, Huang J, Bramlage MP: The role of fine needle aspiration cytology in the diagnosis and management of thymic neoplasia. J Thorac Oncol; 2010 Oct;5(10 Suppl 4):S281-5
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  • [Title] The role of fine needle aspiration cytology in the diagnosis and management of thymic neoplasia.
  • BACKGROUND: Fine needle aspiration biopsy is commonly used to document the metastasis to the mediastinum.
  • It is less often used to make the primary diagnosis of tumors, particularly thymic neoplasms.
  • This is due to fear of sampling error, rarity of thymic tumors, multiplicity of lesions in the mediastinum, and inexperience on the part of the cytopathologist.
  • We show that needle aspiration sampling of thymic tumors, both thymoma and thymic carcinoma, is an accurate method of diagnosis.
  • METHODS AND RESULTS: In our series of 22 thymic tumors aspirated preoperatively and compared with the subsequent surgical resection, the accuracy of a diagnosis of thymoma was 100%, and the accuracy of a diagnosis of carcinoma was 100%.
  • [MeSH-major] Thymoma / diagnosis. Thymus Neoplasms / diagnosis

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  • (PMID = 20859120.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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91. Kim AW: Lymph node drainage patterns and micrometastasis in lung cancer. Semin Thorac Cardiovasc Surg; 2009;21(4):298-308
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Lymph node drainage patterns and micrometastasis in lung cancer.
  • Sentinel lymph node mapping and other reviews of anatomic resections have provided additional information regarding drainage patterns of lymphatic metastases.
  • In light of these efforts, topics related to lymphatic metastases, such as skip metastasis and micrometastasis, still remain the subject of investigation.
  • A review of the recent literature shows that the incidence of macroscopic skip metastasis is approximately 25%.
  • Despite the occurrence of skip metastases, a generalized lymphatic drainage pattern is observed and is consistent with the drainage patterns that are observed among nonskip metastases to the mediastinum.
  • Direct mediastinal drainage or the inability to detect micrometastatic disease due to observational errors or technical inadequacies may explain the presence of skip metastasis.
  • This manuscript reviews the patterns of lymph node drainage from a historical and current perspective to facilitate an understanding of the existing knowledge with respect to skip metastasis and micrometastasis.
  • [MeSH-major] Lung Neoplasms / secondary. Lymph Nodes / pathology. Lymphatic System / pathology
  • [MeSH-minor] Diagnostic Imaging / methods. Humans. Lymphatic Metastasis. Neoplasm Staging. Prognosis

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  • [Copyright] Copyright 2009 Elsevier Inc. All rights reserved.
  • (PMID = 20226342.001).
  • [ISSN] 1532-9488
  • [Journal-full-title] Seminars in thoracic and cardiovascular surgery
  • [ISO-abbreviation] Semin. Thorac. Cardiovasc. Surg.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] United States
  • [Number-of-references] 45
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92. Hellwig D, Baum RP, Kirsch C: FDG-PET, PET/CT and conventional nuclear medicine procedures in the evaluation of lung cancer: a systematic review. Nuklearmedizin; 2009;48(2):59-69, quiz N8-9
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] FDG-PET, PET/CT and conventional nuclear medicine procedures in the evaluation of lung cancer: a systematic review.
  • AIM: Currently, the German and Austrian S3 guidelines on the evaluation and treatment of lung cancer are about to be published whereas the American Colleague of Chest Physicians (ACCP) guidelines were already presented in 2007.
  • An important part of the diagnostic workup of lung cancer will be the evaluation of indeterminate lung lesions and the mediastinal and extrathoracic staging using FDG-PET or PET/CT.
  • To answer the important question for the extent of pathological confirmation needed, the residual risk of mediastinal metastases was calculated for certain constellations of FDG-PET and CT findings.
  • FDG-PET (PET/CT) is the most accurate non-invasive procedure to assess the mediastinal nodal stage, for non-small cell as well as for small cell lung cancer.
  • Unexpected extrathoracic metastases detected by FDG-PET imply important changes in therapeutic management.
  • CONCLUSION: The upcoming S3 guideline on lung cancer will recommend FDG-PET in several indications due to its clinical efficacy well proven by data from literature (high level of evidence).
  • FDG-PET (PET/CT) belongs to the standard of care in lung cancer.
  • [MeSH-minor] Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / radiography. Humans. Lymph Nodes / radiography. Lymphatic Metastasis / radiography. Neoplasm Staging. Prevalence

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  • (PMID = 19333516.001).
  • [ISSN] 0029-5566
  • [Journal-full-title] Nuklearmedizin. Nuclear medicine
  • [ISO-abbreviation] Nuklearmedizin
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Chemical-registry-number] 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Number-of-references] 55
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93. Lyons G, Quadrelli S, Silva C, Vera K, Iotti A, Venditti J, Chertcoff J, Chimondeguy D: Analysis of survival in 400 surgically resected non-small cell lung carcinomas: towards a redefinition of the T factor. J Thorac Oncol; 2008 Sep;3(9):989-93
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • INTRODUCTION: The tumor, node, metastasis (TNM) system has been recognized internationally as the standard for staging disease extension, but despite the improvements of the 1997/2002 international staging system, there may be marked differences in postoperative 5-year survival rates within each stage.
  • There is controversy about the impact of tumor size itself as a variable unrelated to stage.The objective of this study was to analyze the influence of tumor size on the survival in patients with surgically resected non-small cell lung carcinoma (NSCLC).
  • The clinicopathological records of each patient were examined for prognostic factors such as age, sex, right or left side cancer, histology, tumor location, tumor size, clinical nodal stage number, and distribution of metastatic nodes.
  • When only patients without neoplastic hilar or mediastinal metastases (pN0) were included, the difference in survival was significantly different in terms of tumor size (log rank 28.46, p < 0.0001).
  • In the multivariate analysis, tumor size and the T factor were found to have maintained its independent prognostic effects on overall survival.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / mortality. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / mortality. Lung Neoplasms / pathology
  • [MeSH-minor] Female. Follow-Up Studies. Humans. Lymphatic Metastasis. Male. Middle Aged. Neoplasm Staging. Pneumonectomy / mortality. Prognosis. Retrospective Studies. Survival Analysis. Survival Rate. Treatment Outcome

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  • (PMID = 18758301.001).
  • [ISSN] 1556-1380
  • [Journal-full-title] Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • [ISO-abbreviation] J Thorac Oncol
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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94. Tsubaki M, Nemoto K, Yoda N, Hasimoto R, Sunagawa M, Masawa N: Sigmoid colon cancer with mediastinal lymph node metastases. Int Surg; 2007 Jul-Aug;92(4):209-13
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Sigmoid colon cancer with mediastinal lymph node metastases.
  • Mediastinal lymph node metastasis from colorectal cancer is rarely seen.
  • We herein report on a 74-year-old man who was hospitalized with multiple brain metastases and mediastinal lymph node metastasis from an adenocarcinoma of the sigmoid colon.
  • A preoperative brain magnetic resonance image showed multiple brain tumors, and a chest computed tomography (CT) scan indicated a mediastinal tumor.
  • CT-guided aspiration biopsy cytology of the mediastinal tumor showed metastatic adenocarcinoma from a digestive tract tumor.
  • Barium enema and sigmoid colonoscopy showed that the cancer was located in the sigmoid colon.
  • Pathological findings of the specimen showed a moderately differentiated adenocarcinoma that invaded to the subserosa, but no evidence of lymph node metastasis was found.
  • [MeSH-major] Brain Neoplasms / secondary. Mediastinal Neoplasms / secondary. Sigmoid Neoplasms / pathology
  • [MeSH-minor] Aged. Barium Sulfate. Colonoscopy. Contrast Media. Enema. Fatal Outcome. Humans. Lymph Node Excision. Lymphatic Metastasis. Magnetic Resonance Imaging. Male. Tomography, X-Ray Computed

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  • (PMID = 18050829.001).
  • [ISSN] 0020-8868
  • [Journal-full-title] International surgery
  • [ISO-abbreviation] Int Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
  • [Chemical-registry-number] 0 / Contrast Media; 25BB7EKE2E / Barium Sulfate
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95. Chen C, Lin PQ, Lin RB, Kang MQ, Zheng W, Chen DZ: [Application of mediastinoscopy to diagnosis of mediastinal diseases and staging of lung cancer]. Ai Zheng; 2007 Jun;26(6):657-60
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  • [Title] [Application of mediastinoscopy to diagnosis of mediastinal diseases and staging of lung cancer].
  • BACKGROUND & OBJECTIVE: It is still very difficult to make a definite diagnosis for some mediastinal diseases through some examinations, such as CT scan and fibrobronchoscopy.
  • To judge the metastasis of mediastinal lymph nodes exactly for lung cancer patients and make proper staging of lung cancer are important for defining therapeutic schedule and estimating prognosis.
  • This study was to explore the application value and summarize the experience of mediastinoscopy in the diagnosis of mediastinal diseases and the staging of lung cancer with enlarged mediastinal lymph nodes.
  • METHODS: Mediastinoscopy and biopsy were performed in 16 patients with different mediastinal diseases detected by imaging examinations and 14 lung cancer patients with enlarged mediastinal lymph nodes diagnosed by CT scan, PET, or fibrobronchoscopy.
  • The staging of lung cancer was identified according to pathologic diagnosis.
  • RESULTS: Of the 16 patients with different mediastinal diseases clarified by mediastinoscopy, 5 had nodule diseases, 3 had mediastinal lymph node tuberculosis, 2 had mediastinal lymphnoditis, 2 had lymphoma, 1 had extra-gastrointestinal type gastrointestinal malignant interstitialoma,1 had thymoma, 1 had metastatic small cell carcinoma, and 1 had metastatic adenocarcinoma.
  • Of the 14 lung cancer patients with enlarged mediastinal lymph nodes, 6 had metastatic lymph nodes, and 8 had not; all of the 14 cases were accurately staged and received successful operations without severe postoperative complications.
  • CONCLUSION: Mediastinoscopy is a safe, accurate and effective procedure for the diagnosis of mediastinal diseases and the staging of lung cancer.
  • [MeSH-major] Lung Neoplasms / diagnosis. Lymph Nodes / pathology. Lymphatic Metastasis / diagnosis. Mediastinal Diseases / diagnosis. Mediastinoscopy / methods
  • [MeSH-minor] Adolescent. Adult. Aged. Female. Humans. Lymph Node Excision. Male. Mediastinum / pathology. Middle Aged. Neoplasm Staging. Tuberculosis, Lymph Node / diagnosis. Tuberculosis, Lymph Node / pathology. Tuberculosis, Lymph Node / surgery. Young Adult

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  • (PMID = 17562276.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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96. Kuzdzał J, Zieliński M, Papla B, Urbanik A, Wojciechowski W, Narski M, Szlubowski A, Hauer L: The transcervical extended mediastinal lymphadenectomy versus cervical mediastinoscopy in non-small cell lung cancer staging. Eur J Cardiothorac Surg; 2007 Jan;31(1):88-94
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  • [Title] The transcervical extended mediastinal lymphadenectomy versus cervical mediastinoscopy in non-small cell lung cancer staging.
  • OBJECTIVE: To compare the diagnostic yield of the transcervical extended mediastinal lymphadenectomy (TEMLA) and the cervical mediastinoscopy (CM) in detecting metastatic mediastinal lymph nodes in NSCLC patients.
  • The TEMLA revealed mediastinal metastases in 7 patients, and mediastinoscopy in 3.
  • In the TEMLA group one patient out of the 14 with negative nodes was finally found unfit for surgery, and in the remaining 13 lung resections with mediastinal dissection were performed.
  • In the mediastinoscopy group one patient out of the 17 with negative nodes was finally found unfit for surgery and another one refused surgery, so in 15 of them lung resections with mediastinal dissection were performed.
  • In no patient in the TEMLA group did the pathological examination of the operative specimen reveal metastatic lymph nodes, whereas in the mediastinoscopy group metastatic nodes were found in 5 patients.
  • The sensitivity and the NPV of the TEMLA in detecting mediastinal metastases in NSCLC are significantly greater than those of cervical mediastinoscopy.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / pathology. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology
  • [MeSH-minor] Aged. Epidemiologic Methods. False Negative Reactions. Female. Humans. Lymph Node Excision / adverse effects. Lymph Node Excision / methods. Male. Mediastinoscopy / adverse effects. Mediastinoscopy / methods. Mediastinum. Middle Aged. Neck. Neoplasm Staging / methods. Pain, Postoperative / etiology. Research Design

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  • (PMID = 17116398.001).
  • [ISSN] 1010-7940
  • [Journal-full-title] European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • [ISO-abbreviation] Eur J Cardiothorac Surg
  • [Language] eng
  • [Publication-type] Journal Article; Multicenter Study; Randomized Controlled Trial
  • [Publication-country] Germany
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97. Pitoia F, Tamer EE, Schere DB, Passerieu M, Bruno OD, Niepomniszcze H: Usefulness of recombinant human TSH aided radioiodine doses administered in patients with differentiated thyroid carcinoma. Medicina (B Aires); 2006;66(2):125-30
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Patients were divided into two groups: GI (n=17), with previous thyroid bed uptake and undetectable thyroglobulin (Tg) levels under levothyroxine treatment and GII (n=11), with proven metastatic local or distant disease.
  • In GII, the post therapy whole body scan showed pathological uptakes in all cases: in four patients in lungs, in four in mediastinum and in three in lateral neck.
  • In two patients with mediastinum uptake, Tg levels were undetectable after rhTSH.
  • In the follow-up, two patients with lateral neck uptake were rendered disease free, four patients died (three due to thyroid cancer) and five out of the remaining patients have persistent disease.
  • rhTSH stimulated Tg was undetectable in two patients with mediastinal metastasis.

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  • (PMID = 16715760.001).
  • [ISSN] 0025-7680
  • [Journal-full-title] Medicina
  • [ISO-abbreviation] Medicina (B Aires)
  • [Language] eng
  • [Publication-type] Clinical Trial; Journal Article
  • [Publication-country] Argentina
  • [Chemical-registry-number] 0 / Iodine Radioisotopes; 0 / Recombinant Proteins; 9002-71-5 / Thyrotropin; 9010-34-8 / Thyroglobulin
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98. Koga R, Noriyuki T, Kimura A, Okumichi T, Takeshima Y: [Pulmonary pleomorphic carcinoma]. Kyobu Geka; 2005 Nov;58(12):1043-8
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  • Chest computed tomography (CT) showed a rapidly growing tumor with irregular density.
  • Transbronchial lung biopsy revealed the tumor to be malignant.
  • Pathological diagnosis was pleomorphic carcinoma (pT2N2M0, stage IIIA).
  • He died 8 months after surgery due to brain metastasis and mediastinal lymph node metastasis.
  • Chest CT showed a tumor with cavity in the right middle lobe.
  • Pathological diagnosis was also pleomorphic carcinoma (pT2N0M0, stage IB).
  • He has no findings of recurrence nor metastasis 15 months after the operation.

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  • (PMID = 16281853.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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99. Tokunaga M, Masuda A, Mukai M, Nakamura H, Iwaki K, Terachi T: Successful treatment of renal cell carcinoma with mediastinal lymph node metastasis by interleukin-2: a case report. Tokai J Exp Clin Med; 2005 Jul;30(2):111-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Successful treatment of renal cell carcinoma with mediastinal lymph node metastasis by interleukin-2: a case report.
  • Renal cell carcinoma (RCC) of the left kidney with bilateral pulmonary and mediastinal lymph node metastases was diagnosed.
  • Pathological examination confirmed the diagnosis of RCC (pT2pN0M1), so immunotherapy was performed using interleukin-2 (IL-2).
  • The mediastinal lymph node metastases disappeared completely after 5 months of immunotherapy.
  • Although her pulmonary metastases are unchanged, the mediastinal metastases still show complete remission at 14 months postoperatively.
  • [MeSH-minor] Combined Modality Therapy. Female. Humans. Lung Neoplasms / immunology. Lung Neoplasms / secondary. Lung Neoplasms / therapy. Lymphatic Metastasis. Mediastinum. Middle Aged. Nephrectomy. Treatment Outcome

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  • (PMID = 16146201.001).
  • [ISSN] 0385-0005
  • [Journal-full-title] The Tokai journal of experimental and clinical medicine
  • [ISO-abbreviation] Tokai J. Exp. Clin. Med.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Interleukin-2
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100. Nguyen VH, Peloquin S, Lacasse Y: Cost-effectiveness of positron emission tomography for the management of potentially operable non-small cell lung cancer in Quebec. Can Respir J; 2005 Jan-Feb;12(1):19-25
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Cost-effectiveness of positron emission tomography for the management of potentially operable non-small cell lung cancer in Quebec.
  • OBJECTIVE: To evaluate the economic impact and cost-effectiveness of PET scanning in the management of potentially operable non-small cell lung cancer in Quebec.
  • Costs were obtained from the Quebec diagnosis-related group database and Quebec physician fee schedules.
  • Considering the number of new cases and the prevalence of mediastinal metastases, the budget impact would be US dollars 8,613,693.
  • CONCLUSION: The use of PET to detect local and distant metastases in non-small cell lung cancer is an intervention that would require an acceptable investment for each life-year gained.
  • [MeSH-minor] Analysis of Variance. Cost-Benefit Analysis. Decision Trees. Evaluation Studies as Topic. Female. Humans. Male. Neoplasm Staging. Probability. Quebec. Risk Assessment






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