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1. Barbault A, Costa FP, Bottger B, Munden RF, Bomholt F, Kuster N, Pasche B: Amplitude-modulated electromagnetic fields for the treatment of cancer: discovery of tumor-specific frequencies and assessment of a novel therapeutic approach. J Exp Clin Cancer Res; 2009 Apr 14;28:51
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Amplitude-modulated electromagnetic fields for the treatment of cancer: discovery of tumor-specific frequencies and assessment of a novel therapeutic approach.
  • PURPOSE: Because in vitro studies suggest that low levels of electromagnetic fields may modify cancer cell growth, we hypothesized that systemic delivery of a combination of tumor-specific frequencies may have a therapeutic effect.
  • We undertook this study to identify tumor-specific frequencies and test the feasibility of administering such frequencies to patients with advanced cancer.
  • PATIENTS AND METHODS: We examined patients with various types of cancer using a noninvasive biofeedback method to identify tumor-specific frequencies.
  • We offered compassionate treatment to some patients with advanced cancer and limited therapeutic options.
  • RESULTS: We examined a total of 163 patients with a diagnosis of cancer and identified a total of 1524 frequencies ranging from 0.1 Hz to 114 kHz.
  • One patient with hormone-refractory breast cancer metastatic to the adrenal gland and bones had a complete response lasting 11 months.
  • One patient with hormone-refractory breast cancer metastatic to liver and bones had a partial response lasting 13.5 months.
  • Four patients had stable disease lasting for +34.1 months (thyroid cancer metastatic to lung), 5.1 months (non-small cell lung cancer), 4.1 months (pancreatic cancer metastatic to liver) and 4.0 months (leiomyosarcoma metastatic to liver).
  • CONCLUSION: Cancer-related frequencies appear to be tumor-specific and treatment with tumor-specific frequencies is feasible, well tolerated and may have biological efficacy in patients with advanced cancer.

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  • (PMID = 19366446.001).
  • [ISSN] 1756-9966
  • [Journal-full-title] Journal of experimental & clinical cancer research : CR
  • [ISO-abbreviation] J. Exp. Clin. Cancer Res.
  • [Language] eng
  • [Databank-accession-numbers] ClinicalTrials.gov/ NCT00805337
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] England
  • [Chemical-registry-number] 0 / Biomarkers, Tumor
  • [Other-IDs] NLM/ PMC2672058
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2. Suárez G, Valera Z, Gómez MA, Docobo F, Alamo JM: [Etiology and diagnosis of severe retroperitoneal hematoma: therapeutic options and surgical indication]. Cir Esp; 2005 Nov;78(5):328-30

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Etiology and diagnosis of severe retroperitoneal hematoma: therapeutic options and surgical indication].
  • Although the literature on the subject describes a wide variety of causes, in all three patients the etiology was tumoral, consisting of one suprarenal myelolipoma, one renal adenocarcinoma and one suprarenal metastasis from bronchogenic adenocarcinoma.
  • [MeSH-major] Hematoma / diagnosis. Hematoma / etiology

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  • (PMID = 16420851.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Spain
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3. Shantha GP, Kumar AA, Jeyachandran V, Rajamanickam D, Bhaskar E, Paniker VK, Abraham G: Paraneoplastic (non-metastatic) adrenal insufficiency preceded the onset of primary lung cancer by 12 weeks. BMJ Case Rep; 2009;2009

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Paraneoplastic (non-metastatic) adrenal insufficiency preceded the onset of primary lung cancer by 12 weeks.
  • Clinically evident adrenal insufficiency associated with lung cancer is a rare entity.
  • Among reported cases, adrenal insufficiency has occurred with or succeeded the primary lung cancer.
  • Adrenal insufficiency has also been secondary to metastasis to the adrenal gland.
  • The present report concerns a 61-year-old man, a chronic smoker, who presented to us with symptomatic adrenal insufficiency.
  • He had no evidence of lung cancer during this visit.
  • The primary lung cancer was only identified 12 weeks later.
  • Additionally, his adrenals showed no evidence of metastasis.
  • Hence his adrenal insufficiency had been a paraneoplastic manifestation of the lung cancer, and it had also preceded the primary by 12 weeks.

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  • (PMID = 21686682.001).
  • [ISSN] 1757-790X
  • [Journal-full-title] BMJ case reports
  • [ISO-abbreviation] BMJ Case Rep
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] England
  • [Other-IDs] NLM/ PMC3029429
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4. Arvanitis LD, Pitelka LA, Gattuso P: Adrenocortical carcinoma presenting with a peritoneal effusion. Diagn Cytopathol; 2010 Jul;38(7):514-6
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • Although ACC is the most common malignant neoplasm of the adrenal gland, its metastatic spread to the peritoneal cavity is exceptionally unusual.

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  • [Copyright] (c) 2009 Wiley-Liss, Inc.
  • (PMID = 19941369.001).
  • [ISSN] 1097-0339
  • [Journal-full-title] Diagnostic cytopathology
  • [ISO-abbreviation] Diagn. Cytopathol.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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5. Yamazaki K, Sugio K, Yamanaka T, Hirai F, Osoegawa A, Tagawa T, Fukuyama S, Wataya H, Seto T, Ichinose Y: Prognostic factors in non-small cell lung cancer patients with postoperative recurrence following third-generation chemotherapy. Anticancer Res; 2010 Apr;30(4):1311-5
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Prognostic factors in non-small cell lung cancer patients with postoperative recurrence following third-generation chemotherapy.
  • AIM: To analyse the prognostic factors for patients with non-small cell lung cancer (NSCLC) who underwent cytotoxic chemotherapy with third generation agents or epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for recurrence.
  • Univariate analysis showed female gender, age younger than 65 years, ECOG performance status of 0-1, never-smoker status, and adenocarcinoma prolonged survival, whereas metastasis to the liver or adrenal gland shortened survival.
  • Multivariate analysis revealed age, performance status, cell type and metastasis to the adrenal gland to be independent prognostic factors.
  • CONCLUSION: Age, performance status, cell type, and metastasis to the adrenal were independent prognostic factors in NSCLC patients treated with third-generation agents or EGFR-TKI for recurrence.
  • [MeSH-major] Carcinoma, Non-Small-Cell Lung / drug therapy. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / drug therapy. Lung Neoplasms / surgery. Neoplasm Recurrence, Local / pathology
  • [MeSH-minor] Adult. Aged. Aged, 80 and over. Combined Modality Therapy. Female. Humans. Male. Middle Aged. Neoplasm Staging. Prognosis. Protein Kinase Inhibitors / therapeutic use. Receptor, Epidermal Growth Factor / antagonists & inhibitors. Survival Rate


6. Alikhan MA, Williams R, Udaya K, Shaefer RF, Viswamitra SC, Kohli M: Evaluation of an adrenal mass in a patient with progressive prostate cancer reveals pheochromocytoma. Int J Urol; 2006 Jun;13(6):798-800
MedlinePlus Health Information. consumer health - Prostate Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Evaluation of an adrenal mass in a patient with progressive prostate cancer reveals pheochromocytoma.
  • Adrenal masses in cancer patients pose diagnostic problems.
  • We report the case of a 59 years old male with a history of prostate cancer who presented to us with serially rising prostate specific antigen.
  • On imaging studies he had bone lesions and in addition had a 1.7 cm left adrenal mass.
  • Since metastasis to the adrenal gland has rarely been reported in prostate cancer, and since the radiological criteria in our case favored malignancy, we proceeded with hormonal evaluation and fine needle aspiration biopsy of the adrenal mass which proved it to be pheochromocytoma.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Neoplasms, Second Primary / pathology. Pheochromocytoma / pathology. Prostatic Neoplasms / pathology


7. Silvio Estaba L, Madrazo González Z, Pujol Gebelli J, Masdevall Noguera C, Rafecas Renau A, Moreno Llorente P: [Laparoscopic adrenalectomy for suspected isolated adrenal metastasis]. Cir Esp; 2007 Apr;81(4):197-201
MedlinePlus Health Information. consumer health - Adrenal Gland Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laparoscopic adrenalectomy for suspected isolated adrenal metastasis].
  • [Transliterated title] Adrenalectomía laparoscópica por sospecha de metástasis adrenal solitaria.
  • INTRODUCTION: Isolated adrenal metastasis is uncommon.
  • The aim of this study was to evaluate the indications, diagnosis and utility of laparoscopic adrenalectomy (LA) in patients with isolated adrenal metastasis.
  • PATIENTS AND METHOD: A prospective study was conducted in patients with current or previous tumoral disease and with isolated adrenal metastasis.
  • Fifteen LA were performed (one patient was found to have an inoperable tumor at surgery).
  • The most common metastatic disease was non-small cell lung carcinoma (NSCLC) (10 patients), followed by colorectal cancer metastasis (two patients).
  • CONCLUSIONS: LA for metastasis can be performed without oncological disadvantage and should be offered to patients with resectable disease, a DFI > 6 months, and a tumoral size that allows laparoscopic resection.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenalectomy. Laparoscopy / methods

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  • (PMID = 17403355.001).
  • [ISSN] 0009-739X
  • [Journal-full-title] Cirugía española
  • [ISO-abbreviation] Cir Esp
  • [Language] spa
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Spain
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8. Meyer A, Behrend M: Is pancreatic resection justified for metastasis of papillary thyroid cancer? Anticancer Res; 2006 May-Jun;26(3B):2269-73
MedlinePlus Health Information. consumer health - Thyroid Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Is pancreatic resection justified for metastasis of papillary thyroid cancer?
  • BACKGROUND: This case report describes a patient with symptomatic anaemia due to a bleeding duodenal metastasis from metastasising differentiated thyroid cancer (DTC), which was treated by partial duodenopancreatectomy (DP).
  • This patient had suffered multiple cervical recurrences of differentiated papillary thyroid cancer, which had been treated by several resections and irradiation, and an adrenal gland metastasis, via adrenalectomy.
  • Abdominal computed tomography showed an enlarged pancreatic head, an upper gastrointestinal endoscopy revealed a bleeding ulcer in the duodenum, and a biopsy revealed metastasis from DTC.
  • Due to the symptomatic metastasis, a partial DP was performed; the postoperative course was uneventful.
  • Histopathological examination revealed metastasis of the DTC next to the papilla lying in the head of the pancreas, with growth into the muscularis propria of the duodenum.
  • The patient survived for another 41/2 years before dying from progressive metastatic disease elsewhere.
  • CONCLUSION: DP for metastatic disease should be considered in selected patients for alleviation of the symptoms and prolongation of survival, as long as this operation is performed by experienced surgeons who can achieve minimal morbidity and mortality.
  • [MeSH-major] Carcinoma, Papillary / secondary. Carcinoma, Papillary / surgery. Duodenal Neoplasms / secondary. Duodenal Neoplasms / surgery. Pancreaticoduodenectomy. Thyroid Neoplasms / pathology


9. Hiroi N, Yanagisawa R, Yoshida-Hiroi M, Endo T, Kawase T, Tsuchida Y, Toyama K, Shibuya K, Nakata K, Yoshino G: Retroperitoneal hemorrhage due to bilateral adrenal metastases from lung adenocarcinoma. J Endocrinol Invest; 2006 Jun;29(6):551-4
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Retroperitoneal hemorrhage due to bilateral adrenal metastases from lung adenocarcinoma.
  • A 56-yr-old man was admitted to our university hospital for severe back pain one month after a resection for lung adenocarcinoma (stage IIIA) without evidence of the adrenal mass.
  • Computed tomography (CT) of the abdomen showed bilateral bleeding of adrenal tumors.
  • Core-needle biopsy was performed on the right adrenal tumor and revealed adenocarcinoma cells mimicking a primary lung tumor previously examined.
  • We diagnosed retroperitoneal hemorrhage due to bilateral adrenal gland metastasis from lung adenocarcinoma with adrenal insufficiency.
  • Adrenal metastases most commonly originate from a primary lung tumor, followed by stomach, esophagus and liver/bile ducts.
  • Bilateral adrenal metastases were noted in approximately half of all adrenal metastases patients.
  • Clinically significant adrenal hemorrhage by metastasis is exceedingly rare and non-specific symptoms, such as abdominal, chest or back pain, nausea and vomiting, confusion, weakness, hypotension, shock and high fever, are often observed in these patients.
  • We present a case of massive retroperitoneal hemorrhage and adrenal insufficiency due to adrenal gland metastasis from adenocarcinoma of lung.
  • [MeSH-major] Adenocarcinoma / secondary. Adrenal Gland Neoplasms / secondary. Adrenal Insufficiency / etiology. Hemorrhage / etiology. Lung Neoplasms / pathology

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  • (PMID = 16840834.001).
  • [ISSN] 0391-4097
  • [Journal-full-title] Journal of endocrinological investigation
  • [ISO-abbreviation] J. Endocrinol. Invest.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Italy
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10. Rosenblatt GS, Takesita K, Fuchs GJ, Colquhoun SD, Ng CS: Adrenal metastasis with inferior vena cava tumor thrombus through adrenal vein. Urology; 2009 Aug;74(2):290-1
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenal metastasis with inferior vena cava tumor thrombus through adrenal vein.
  • Abdominal ultrasonography showed a large right renal mass.
  • Magnetic resonance imaging revealed a 12-cm renal mass and a separate 7.5-cm ipsilateral adrenal mass, with a tumor thrombus extending through the adrenal vein and into the inferior vena cava.
  • Right radical nephrectomy/adrenalectomy with caval tumor thrombectomy was performed, and both lesions were diagnosed as renal cell carcinoma.
  • We report on an unusual case of a large renal cell carcinoma with metastasis to the adrenal gland and vena caval extension by way of the adrenal venous system, without renal vein thrombus.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Adrenal Glands / blood supply. Carcinoma, Renal Cell / secondary. Kidney Neoplasms / pathology. Neoplastic Cells, Circulating / pathology. Vena Cava, Inferior / pathology

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  • (PMID = 19501878.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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11. Mouracade P, Dettloff H, Schneider M, Debras B, Jung JL: Radio-frequency ablation of solitary adrenal gland metastasis from renal cell carcinoma. Urology; 2009 Dec;74(6):1341-3
MedlinePlus Health Information. consumer health - Kidney Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Radio-frequency ablation of solitary adrenal gland metastasis from renal cell carcinoma.
  • OBJECTIVES: To evaluate the early clinical experience associated with radio-frequency (RF) ablation in patients with solitary adrenal gland metastasis of renal cell carcinoma (RCC).
  • METHODS: A total of 5 patients were treated with RF ablation of adrenal gland metastasis from RCC under computed tomography (CT) guidance between 2006 and 2007.
  • RESULTS: Five patients were treated with a RF ablation of the adrenal metastasis.
  • The average age of the patients was 69.4 +/- 11.1 years (57-87), the average time between the radical nephrectomy and the onset of adrenal metastasis was 5.2 +/- 1.3 years (4-7), and average diameter of the tumor was 3.9 +/- 1.4 cm (2-6).
  • A year after RF, four patients had a total necrosis of their tumor on CT and 1 had an active tumor for which the patient received a second course of RF.
  • An abscess of the adrenal gland had occurred in 1 case requiring a percutaneous drainage.
  • CONCLUSIONS: The treatment of metastatic adrenal gland with RF broadens the range of treatment of metastatic RCC.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Catheter Ablation. Kidney Neoplasms / pathology

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  • (PMID = 19781749.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Journal Article
  • [Publication-country] United States
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12. Niinobu T, Yamashita S, Nakagawa S, Amano M, Higaki N, Hayashida H, Nakao A, Takiuchi H, Sakon M: [Laparoscopic adrenalectomy for the adrenal gland metastasis from hepatocellular carcinoma]. Gan To Kagaku Ryoho; 2006 Nov;33(12):1765-7
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Laparoscopic adrenalectomy for the adrenal gland metastasis from hepatocellular carcinoma].
  • A 4 x 3.5 cm neoplasm at the left adrenal was detected by CT inspection this time.
  • The diagnosis was a metastatic adrenal gland tumor from HCC.
  • Since HCC is controlled by TAE, the metastatic lesions were not found in other organs and were isolated, of 10 cm or less in size.
  • Pathologial diagnosis was a metastatic adrenal gland tumor from moderately differentiated hepatocellular carcinoma.
  • When observing the adaptation standard strictly to the high-risk case, it was thought that the metastatic tumor extraction under laparoscopic surgery could become a low stress cure in consideration of QOL being useful as a local treatment for cancer.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Carcinoma, Hepatocellular / pathology. Laparoscopy. Liver Neoplasms / pathology

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  • (PMID = 17212101.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
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13. Kondo K, Chijiiwa K, Nagano M, Hamasuna R, Yamashita A, Marutsuka K, Takahashi N, Akiyama Y: Two-stage operation for hepatocellular carcinoma with synchronous bilateral adrenal gland metastasis. J Hepatobiliary Pancreat Surg; 2008;15(2):232-6
MedlinePlus Health Information. consumer health - Liver Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Two-stage operation for hepatocellular carcinoma with synchronous bilateral adrenal gland metastasis.
  • Hepatocellular carcinoma (HCC) frequently metastasizes to the adrenal glands.
  • The surgical strategy for HCC associated with bilateral adrenal gland metastasis is complicated because of the possibility of both postoperative hepatic failure and adrenal insufficiency.
  • We herein report a patient with HCC with synchronous bilateral adrenal gland metastasis that was treated successfully with a two-stage operation.
  • A 58-year-old man with HCC (12 cm in diameter) in the right lobe of the liver and bilateral adrenal gland tumors (right, 4 cm in diameter; left, 5 cm in diameter) was admitted to our hospital.
  • Two-stage surgery is a safe treatment option for giant HCC with synchronous bilateral adrenal gland metastasis.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Carcinoma, Hepatocellular / surgery. Liver Neoplasms / surgery

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  • (PMID = 18392722.001).
  • [ISSN] 0944-1166
  • [Journal-full-title] Journal of hepato-biliary-pancreatic surgery
  • [ISO-abbreviation] J Hepatobiliary Pancreat Surg
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
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14. Tsoumakidou G, Buy X, Zickler P, Zupan M, Douchet MP, Gangi A: Life-threatening complication during percutaneous ablation of adrenal gland metastasis: Takotsubo syndrome. Cardiovasc Intervent Radiol; 2010 Jun;33(3):646-9
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Life-threatening complication during percutaneous ablation of adrenal gland metastasis: Takotsubo syndrome.
  • A rare life-threatening complication during percutaneous cryoablation of an adrenal gland metastasis from a lung carcinoma is reported.
  • These findings led to the diagnosis of Takotsubo cardiomyopathy left ventricular dysfunction syndrome.
  • This is the first case of Takotsubo cardiomyopathy occurring as a complication during percutaneous ablation of an adrenal gland tumor.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Cryosurgery / adverse effects. Lung Neoplasms / pathology. Takotsubo Cardiomyopathy / etiology

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  • (PMID = 19495870.001).
  • [ISSN] 1432-086X
  • [Journal-full-title] Cardiovascular and interventional radiology
  • [ISO-abbreviation] Cardiovasc Intervent Radiol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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15. Miyazaki T, Tagawa T, Nakamura A, Yamasaki N, Hashizume S, Matsumoto K, Taguchi T, Morino S, Nagayasu T: [Surgical treatment for stage IV lung cancer]. Kyobu Geka; 2006 Jan;59(1):36-40
MedlinePlus Health Information. consumer health - Lung Cancer.

  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] [Surgical treatment for stage IV lung cancer].
  • OBJECTIVE: To find out the optimal surgical indication in stage IV lung cancer patients, we evaluated them retrospectively.
  • The metastatic lesions were lung (33.9%), brain (24.2%), liver, bone, adrenal gland and so on.
  • The overall survival rate of stage IV lung cancer was 10.4% at 5-year.
  • Five-year survival for patients with lung or brain metastasis who had no lymph node metastasis were significantly more superior than those with lymph node metastasis (p=0.0389, 0.0021).
  • Two were lung and the others were brain and adrenal gland metastasis without lymph node metastasis.
  • CONCLUSION: Stage IV lung cancer with lung or brain or adrenal gland metastasis without lymph node metastasis should be resected.
  • [MeSH-minor] Adenocarcinoma / mortality. Adenocarcinoma / surgery. Adult. Aged. Aged, 80 and over. Brain Neoplasms / mortality. Brain Neoplasms / secondary. Female. Humans. Male. Middle Aged. Neoplasm Staging / mortality. Retrospective Studies. Survival Analysis

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  • (PMID = 16440683.001).
  • [ISSN] 0021-5252
  • [Journal-full-title] Kyobu geka. The Japanese journal of thoracic surgery
  • [ISO-abbreviation] Kyobu Geka
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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16. Szolar DH, Korobkin M, Reittner P, Berghold A, Bauernhofer T, Trummer H, Schoellnast H, Preidler KW, Samonigg H: Adrenocortical carcinomas and adrenal pheochromocytomas: mass and enhancement loss evaluation at delayed contrast-enhanced CT. Radiology; 2005 Feb;234(2):479-85
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Adrenocortical carcinomas and adrenal pheochromocytomas: mass and enhancement loss evaluation at delayed contrast-enhanced CT.
  • PURPOSE: To retrospectively measure the adrenal gland attenuation and the percentage loss of adrenal gland enhancement at delayed contrast medium-enhanced computed tomography (CT) in patients with adrenocortical carcinomas and pheochromocytomas and to compare these data with those in patients with adenomas and metastases.
  • Eleven patients with proved adrenocortical carcinoma, 17 with proved pheochromocytoma, 23 with adrenal adenoma, and 16 with metastasis to the adrenal gland underwent helical CT.
  • At optimal threshold values of 50% for absolute percentage of enhancement loss and 40% for relative percentage of enhancement loss at 10 minutes, both the sensitivity and the specificity for the diagnosis of adenoma were 100% when adenomas were compared with carcinomas, pheochromocytomas, and metastases.
  • CONCLUSION: The enhancement loss in adrenocortical carcinomas and pheochromocytomas is similar to that in adrenal metastases but significantly less than that in adrenal adenomas.
  • The percentage change in contrast material washout is a useful adjunct to absolute CT attenuation values in differentiating adrenal adenomas from adrenocortical carcinomas and pheochromocytomas.
  • [MeSH-major] Adrenal Cortex Neoplasms / radiography. Adrenal Gland Neoplasms / radiography. Adrenocortical Carcinoma / radiography. Pheochromocytoma / radiography. Tomography, X-Ray Computed / methods

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  • [Copyright] (c) RSNA, 2005.
  • [CommentIn] Radiology. 2005 Sep;236(3):1112-3 [16118181.001]
  • [CommentIn] Radiology. 2006 Jan;238(1):373; author reply 373-4 [16373781.001]
  • (PMID = 15671003.001).
  • [ISSN] 0033-8419
  • [Journal-full-title] Radiology
  • [ISO-abbreviation] Radiology
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] United States
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17. Sesmero JH, Redondo CC, Delgado MC, Royo FC, Tesedo VR, Oceja JM: Intravesical sealing of the distal ureter in nephroureterectomy. Arch Esp Urol; 2010 Apr;63(3):223-9
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  • The tumor settled on the renal pelvis in 12 cases and on the proximal ureter in 2.
  • One of the patients had bladder recurrence and another one developed metastasis to the suprarenal gland that was treated satisfactorily.
  • CONCLUSIONS: Quick sealing of distal ureter by transvesical application of a clip before its endoscopic excision in nephrourecterectomy is a sound technique from an oncological point of view, with an acceptable complication rate that avoids a second open time to manage distal ureter.

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  • [CommentIn] Arch Esp Urol. 2010 Apr;63(3):230 [21109719.001]
  • (PMID = 20431186.001).
  • [ISSN] 1576-8260
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] eng; spa
  • [Publication-type] Journal Article
  • [Publication-country] Spain
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18. Kobayashi E, Kawai A, Seki K, Tateishi U, Beppu Y: Bilateral adrenal gland metastasis from malignant fibrous histiocytoma: value of [F-18]FDG PET-CT for diagnosis of occult metastases. Ann Nucl Med; 2006 Dec;20(10):695-8
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  • [Title] Bilateral adrenal gland metastasis from malignant fibrous histiocytoma: value of [F-18]FDG PET-CT for diagnosis of occult metastases.
  • We report a 71-year-old woman with malignant fibrous histiocytoma of the right buttock and thigh that metastasized to the bilateral adrenal glands without development of pulmonary metastasis.
  • Whole-body [F-18]FDG PET-CT showed abnormal tracer uptakes in the bilateral adrenal glands in addition to high accumulation in the primary soft tissue tumors.
  • CT-guided needle biopsy revealed that both of the adrenal lesions were metastatic malignant fibrous histiocytoma.
  • There was no pulmonary or other visceral metastasis.
  • To the authors' knowledge, this is the first report of malignant fibrous histiocytoma metastatic to the bilateral adrenal glands without development of pulmonary metastases.
  • This case illustrates the excellence of [F-18]FDG PET-CT scan for diagnosis of occult metastases from soft tissue sarcomas.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / secondary. Fluorodeoxyglucose F18. Histiocytoma, Malignant Fibrous / diagnosis. Histiocytoma, Malignant Fibrous / secondary. Neoplasms, Unknown Primary / diagnosis. Positron-Emission Tomography / methods. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Aged. Female. Humans. Liver Neoplasms / diagnosis. Liver Neoplasms / secondary. Radiopharmaceuticals

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  • (PMID = 17385309.001).
  • [ISSN] 0914-7187
  • [Journal-full-title] Annals of nuclear medicine
  • [ISO-abbreviation] Ann Nucl Med
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
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19. Debevec L, Erzen J, Debeljak A, Crnjac A, Kovac V: Exploratory thoracotomy and its influence on the survival of patients with lung cancer. Wien Klin Wochenschr; 2006 Aug;118(15-16):479-84
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  • [Title] Exploratory thoracotomy and its influence on the survival of patients with lung cancer.
  • PURPOSE: To evaluate diagnostic procedures, reasons for exploratory thoracotomy (ET), causes of unresectability of lung cancer, possibility for reducing numbers of ETs, and the influence of ET on survival.
  • PATIENTS AND METHODS: Between 1990 and 1999, 1808 patients with lung cancer were operated on.
  • The clinical stages were: three patients in stage IA, 28 in IB, one in IIA, 35 in IIB, 50 in IIIA, 10 in IIIB (all due to invasion of the mediastinum), and four patients in IV (three with ipsilateral pulmonary and one with solitary suprarenal metastasis).
  • The reasons for ET were: diagnosis of preoperatively unverified tumor in one patient, necessity for pneumonectomy in the case of poor pulmonary function in 11 patients, and unresectability in 119 (due to invasion of the mediastinum in 98 patients, thoracic wall in three and vertebral body in one, and due to pleural metastases in 17 patients).
  • [MeSH-minor] Adrenal Gland Neoplasms / secondary. Adult. Aged. Aged, 80 and over. Chi-Square Distribution. Female. Humans. Lung / pathology. Male. Middle Aged. Neoplasm Invasiveness. Neoplasm Staging. Radiography, Thoracic. Survival Analysis. Tomography, X-Ray Computed

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  • (PMID = 16957979.001).
  • [ISSN] 0043-5325
  • [Journal-full-title] Wiener klinische Wochenschrift
  • [ISO-abbreviation] Wien. Klin. Wochenschr.
  • [Language] eng
  • [Publication-type] Comparative Study; Evaluation Studies; Journal Article
  • [Publication-country] Austria
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20. Huang ZM, Li HZ, Xiao H, Ji ZG: [Melanoma adrenal metastasis: report of 3 cases and literature review]. Zhonghua Yi Xue Za Zhi; 2010 Apr 27;90(16):1123-5
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  • [Title] [Melanoma adrenal metastasis: report of 3 cases and literature review].
  • OBJECTIVE: To investigate the clinical diagnosis, treatment and prognosis of melanoma adrenal metastasis.
  • METHODS: A total of 48 cases of malignant melanoma from 1985 to 2007 were reviewed.
  • And three cases of melanoma adrenal metastasis were analyzed.
  • The disease-free interval to adrenal metastasis were 25, 37, 33 months respectively.
  • Two presented with flank or abdominal discomfort and another one had adrenal metastasis on routine examination.
  • The maximal diameters of metastasis were 5, 8 and 12 cm respectively.
  • The CT value of adrenal metastasis had a range of 9 - 45 Hu in plain scan.
  • RESULTS: One patient with concurrent lymph node metastasis received non-operative therapy with interleukin-2.
  • The other two cases underwent complete resection of melanoma metastasis.
  • When contralateral adrenal metastasis of melanoma was found 6 months later, left adrenalectomy laparoscopically was performed.
  • One had multiple metastasis in 16 months and died at 21 months.
  • Another was alive without recurrence or new metastasis at 30 months.
  • CONCLUSION: Melanoma metastasis to adrenal gland is rare and it generally has a poor prognosis.
  • Patients with adrenal metastases from melanoma, either isolated or with a limited number of additional metastases, may achieve a survival benefit from surgical resection if all visible lesions are removed.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Melanoma / pathology. Skin Neoplasms / pathology
  • [MeSH-minor] Aged. Aged, 80 and over. Female. Humans. Male. Middle Aged. Neoplasm Metastasis. Prognosis

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  • (PMID = 20646432.001).
  • [ISSN] 0376-2491
  • [Journal-full-title] Zhonghua yi xue za zhi
  • [ISO-abbreviation] Zhonghua Yi Xue Za Zhi
  • [Language] chi
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] China
  • [Number-of-references] 8
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21. Rosales Leal JL, Rodríguez Herrera F, Ortiz Gorráiz M, Honrubia Vílchez B, Fernández Sánchez A, Vázquez Alonso F, Pascual Geler M, Martínez Morcillo A, Vicente Prados J, Cózar Olmo JM, Espejo Maldonado E, Tallada Buñuel M: [Metachronous adrenal metastasis in two patients undergoing radical nephrectomy for primary renal cell carcinoma]. Arch Esp Urol; 2006 Oct;59(8):779-84
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  • [Title] [Metachronous adrenal metastasis in two patients undergoing radical nephrectomy for primary renal cell carcinoma].
  • [Transliterated title] Metástasis suprarrenal metacrónica en 2 pacientes sometidos a nefrectomía radical por carcinoma de células renales primario.
  • OBJECTIVES: We report two exceptional cases of metachronous adrenal metastasis of renal cell carcinomas and perform a bibliographic review.
  • After the evaluation of various features such as frequency, etiopathogenesis, diagnosis and follow-up of these patients we conclude that these metastases are rare, and they usually appear late in the evolution of patients with low stage renal cell carcinoma.
  • RESULTS/CONCLUSIONS: Once reviewed the treatment and checked the absence of guidelines for the therapeutic management of these patients we propose surgery for the adrenal metastasis as well as adjuvant treatment with immunotherapy.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / pathology. Kidney Neoplasms / surgery. Nephrectomy

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  • (PMID = 17153496.001).
  • [ISSN] 0004-0614
  • [Journal-full-title] Archivos españoles de urología
  • [ISO-abbreviation] Arch. Esp. Urol.
  • [Language] spa
  • [Publication-type] Case Reports; English Abstract; Journal Article; Review
  • [Publication-country] Spain
  • [Number-of-references] 26
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22. Zeng ZC, Tang ZY, Fan J, Zhou J, Qin LX, Ye SL, Sun HC, Wang BL, Zhang JY, Yu Y, Cheng JM, Wang XL, Guo W: Radiation therapy for adrenal gland metastases from hepatocellular carcinoma. Jpn J Clin Oncol; 2005 Feb;35(2):61-7
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  • [Title] Radiation therapy for adrenal gland metastases from hepatocellular carcinoma.
  • BACKGROUND: The adrenal gland is a common site of extrahepatic metastases from hepatocellular carcinoma.
  • Methods previously tried for the management of adrenal gland metastasis of hepatocellular carcinoma included surgical resection, transarterial chemoembolization or percutaneous ethanol injection, on the basis of case reports.
  • External beam radiation therapy has seldom been applied for patients with adrenal gland metastases.
  • METHODS: We retrospectively studied 22 patients with adrenal metastases from hepatocellular carcinoma who were treated with limited-field external beam radiation therapy.
  • The radiation dose to the adrenal lesion ranged from 36 to 54 (median 50) Gy, while the intrahepatic lesions were treated with either surgical resection or transarterial chemoembolization.
  • RESULTS: Among the 14 patients who had pain related to adrenal metastases, 11 (78.6%) had complete pain relief without medication that lasted until death.
  • No patient died from complications related to adrenal metastasis.
  • CONCLUSION: Adrenal metastases from hepatocellular carcinoma are sensitive to radiation treatment.
  • Radiation therapy with 50 Gy for adrenal gland metastases is a good palliative therapy with reasonable safety.
  • [MeSH-major] Adrenal Gland Neoplasms / radiotherapy. Adrenal Gland Neoplasms / secondary. Carcinoma, Hepatocellular / radiotherapy. Carcinoma, Hepatocellular / secondary. Liver Neoplasms / pathology
  • [MeSH-minor] Adult. Aged. Female. Humans. Lymphatic Metastasis. Male. Middle Aged. Palliative Care. Radiotherapy Dosage. Retrospective Studies. Survival Rate

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  • (PMID = 15709088.001).
  • [ISSN] 0368-2811
  • [Journal-full-title] Japanese journal of clinical oncology
  • [ISO-abbreviation] Jpn. J. Clin. Oncol.
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Japan
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23. Kuczyk M, Wegener G, Jonas U: The therapeutic value of adrenalectomy in case of solitary metastatic spread originating from primary renal cell cancer. Eur Urol; 2005 Aug;48(2):252-7
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  • [Title] The therapeutic value of adrenalectomy in case of solitary metastatic spread originating from primary renal cell cancer.
  • INTRODUCTION: Solitary adrenal metastases occur in about 1.2-10% of renal cell cancer patients.
  • Since the vast majority of intraadrenal lesions can be detected preoperatively, we and others have recently recommended to renounce a routine adrenalectomy during surgery of renal cell cancer.
  • However, the impact of adrenalectomy on the patients' clinical prognosis in case of a solitary metastatic lesion within the adrenal gland remains an issue of controversial discussion.
  • PATIENTS AND METHOD: Between 1981 and 2000, 648 patients (440 males and 208 females) underwent nephrectomy in combination with adrenalectomy in our clinic for the diagnosis of renal cell cancer.
  • The median age at first diagnosis was 59 (range 33-84) and 60 (range 20-85) years for male and female patients, respectively.
  • Although metastases of the adrenal gland were diagnosed in 48 patients, solitary intraadrenal metastases without further systemic spread were observed in only 13 cases.
  • Several patients' and tumor characteristics (age, tumor stage and size, the presence of regional lymph node metastases, the presence of metastatic lesions at different organ sites as well as the detection of solitary intraadrenal metastases) were correlated with the patients' overall survival by univariate and multivariate statistical analysis (logistic Cox regression analysis).
  • The median long - term survival was 13.8 years and 11.7 years for patients with no evidence of metastatic spread as well as for patients with a solitary intraadrenal metastatic lesion, respectively.
  • Accordingly, the long - term survival rates at 5 and 10 years after surgery were 66%/50% and 51%/51% for patients with no evidence of metastatic spread or isolated intraadrenal metastases.
  • DISCUSSION: For patients with a solitary intraadrenal metastatic lesion, adrenalectomy is a potentially curative treatment option.
  • The observation that the long - term survival of the latter patients is comparable to that of patients with organ - confined disease might suggest the establishment of a separate TNM - category for patients revealing a solitary metastasis within the adrenal gland and no hint at further systemic metastatic spread.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Carcinoma, Renal Cell / secondary. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / pathology


24. Balestra MR, Napolitano L, Legnini M, Innocenti P: [Laparoscopic surgery of adrenal gland metastasis: case report]. Suppl Tumori; 2005 May-Jun;4(3):S130-1
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  • [Title] [Laparoscopic surgery of adrenal gland metastasis: case report].
  • [Transliterated title] La chirurgia laparoscopica delle metastasi surrenaliche: case report.
  • OBJECTIVE: Laparoscopic adrenalectomy is unanimously recognised as the gold standard for the surgical treatment of adrenal lesion.
  • Also the role of laparoscopic adrenalectomy (LA) for metastasis is controversial.
  • This study, in according with literature dates, aimed to confirm that patients are most likely to have prolonged survival after resection of adrenal metastases and confirms that oncological outcome of laparoscopic adrenalectomy are similar with open adrenalectomy.
  • PATIENT AND METHODS: The study included patients who underwent LA from 2000 to 2005.
  • Indications for LA were adrenal masses with no radiological evidence of involvement of the surrounding structure, or solitary metastases with well-controlled primary cancer.
  • The variable evaluated were port-site and intra-addominal recurrence, distant metastasis and survival time.
  • Primary tumors were the followings: lymphoma non-Hodgkin, lung cancer.
  • Patients age was mean 69 (range, 62-77), the lesions were at right adrenal gland.
  • CONCLUSION: LA seems to be a feasible option if the principles of oncological surgery are respected.
  • Adrenalectomy for metastasis, with intent to prolong survival, should be offered to patient with favourable tumor biology, such as those with significant DFI.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Laparoscopy

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  • (PMID = 16437949.001).
  • [ISSN] 2283-5423
  • [Journal-full-title] I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]
  • [ISO-abbreviation] Suppl Tumori
  • [Language] ita
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Italy
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25. Xu J, Wang R, Xie ZH, Odero-Marah V, Pathak S, Multani A, Chung LW, Zhau HE: Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis. Prostate; 2006 Nov 1;66(15):1664-73
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  • [Title] Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis.
  • BACKGROUND: The ARCaP cell line was established from the ascites fluid of a patient with metastatic prostate cancer.
  • This study characterized the host microenvironmental role in cancer progression, epithelial to mesenchymal transition (EMT), and bone and adrenal metastasis in parental ARCaP and its derived cell subclones.
  • In vivo gene expression, behavior, and metastasis of ARCaP subclones were analyzed by serial intracardiac injections into SCID mice.
  • RESULTS: ARCaP(E) cells, with cobblestone morphology, underwent EMT through cellular interaction with host bone and adrenal gland.
  • Lineage-derived ARCaP(M) cells, with spindle-shape fibroblastic morphology, exhibited decreased cell adhesion and increased metastasis to bone and adrenal gland.
  • CONCLUSIONS: ARCaP uniquely models the molecular basis of prostate cancer bone and adrenal metastases and epithelial to mesenchymal transition.
  • [MeSH-major] Adenocarcinoma / secondary. Adrenal Gland Neoplasms / secondary. Bone Neoplasms / secondary. Epithelial Cells / pathology. Mesoderm / pathology. Prostatic Neoplasms / pathology
  • [MeSH-minor] Animals. Cell Adhesion. Cell Movement. Cell Transformation, Neoplastic / pathology. Clone Cells. Disease Progression. Environment. Humans. Male. Mice. Mice, Nude. Neoplasm Invasiveness / pathology. Neoplasm Invasiveness / physiopathology. Neoplasm Transplantation. Organ Specificity / genetics. Tumor Cells, Cultured


26. Mittendorf EA, Lim SJ, Schacherer CW, Lucci A, Cormier JN, Mansfield PF, Gershenwald JE, Ross MI, Lee JE: Melanoma adrenal metastasis: natural history and surgical management. Am J Surg; 2008 Mar;195(3):363-8; discussion 368-9
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  • [Title] Melanoma adrenal metastasis: natural history and surgical management.
  • BACKGROUND: Few data exist regarding melanoma metastasis to the adrenal gland.
  • METHODS: A retrospective review of melanoma patients with adrenal metastasis was performed.
  • RESULTS: One hundred fifty-four patients with adrenal metastasis were identified.
  • The median survival for the entire group was 6.4 months and was negatively impacted by the presence of synchronous metastasis or an elevated LDH.
  • CONCLUSIONS: Patients with melanoma adrenal metastasis have a poor prognosis.
  • Surgical treatment should be considered only in highly selected patients, such as those with limited extra-adrenal metastatic disease who can be rendered disease free.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Melanoma / surgery. Skin Neoplasms / surgery

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  • (PMID = 18206850.001).
  • [ISSN] 1879-1883
  • [Journal-full-title] American journal of surgery
  • [ISO-abbreviation] Am. J. Surg.
  • [Language] eng
  • [Grant] United States / NCI NIH HHS / CA / P50 CA93459
  • [Publication-type] Journal Article; Research Support, N.I.H., Extramural
  • [Publication-country] United States
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27. Kpodonu J, Warso MA, Massad MG: Osteosarcoma invading adrenal gland: rare cause of adrenal mass. Urology; 2005 Jun;65(6):1226
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  • [Title] Osteosarcoma invading adrenal gland: rare cause of adrenal mass.
  • Adrenal gland metastasis from osteogenic sarcoma is extremely rare and is an atypical location for metastasis.
  • Vascular hepatic exclusion techniques and the use of venovenous bypass with cardiac surgical techniques may be required to resect large adrenal masses that have invaded the inferior vena cava to achieve curative resection.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Femoral Neoplasms / pathology. Osteosarcoma / secondary
  • [MeSH-minor] Adult. Humans. Male. Neoplasm Invasiveness. Vena Cava, Inferior / pathology

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  • (PMID = 15922441.001).
  • [ISSN] 1527-9995
  • [Journal-full-title] Urology
  • [ISO-abbreviation] Urology
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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28. Meyer A, Behrend M: State of the art management of adrenal masses--"how to do it?". Eur J Med Res; 2006 Sep 29;11(9):397-404
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] State of the art management of adrenal masses--"how to do it?".
  • By the frequent use of computed tomography or ultrasound the detection of incidentally found adrenal tumours has become a common problem.
  • Most incidentally-found adrenal tumours are benign non-functioning cortical adenomas.
  • But benign functioning tumours producing aldosterone, cortisol or catecholamines, adrenocortical carcinoma or adrenal gland metastasis can also be found.
  • This review deals with the different forms of adrenal tumours regarding the optimal diagnostic and therapeutic approach to give physicians an easy-to-follow guideline.
  • [MeSH-major] Adrenal Gland Neoplasms / therapy

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  • (PMID = 17101464.001).
  • [ISSN] 0949-2321
  • [Journal-full-title] European journal of medical research
  • [ISO-abbreviation] Eur. J. Med. Res.
  • [Language] eng
  • [Publication-type] Journal Article; Review
  • [Publication-country] Germany
  • [Number-of-references] 50
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29. Saeki H, Anegawa G, Masuda T, Ohta R, Honda M, Kai T, Kaneko S, Anai H, Nakamura Y, Yokoyama S: [A case of inoperable gastric small cell carcinoma effectively treated by chemotherapy and radiotherapy]. Gan To Kagaku Ryoho; 2006 Jul;33(7):977-9
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  • He was diagnosed to have an inoperable gastric small cell carcinoma with severe lymph node metastases and left adrenal gland metastasis.
  • Primary and metastatic foci had obviously diminished.
  • Metastatic foci were decreased and his symptom was improved by successful radiotherapy.
  • We conclude that chemotherapy and radiotherapy are effective for primary and metastatic lesions of gastric small cell carcinoma.
  • [MeSH-minor] Aged. Brain Neoplasms / radiotherapy. Brain Neoplasms / secondary. Camptothecin / administration & dosage. Camptothecin / analogs & derivatives. Cisplatin / administration & dosage. Combined Modality Therapy. Cranial Irradiation. Drug Administration Schedule. Drug Combinations. Etoposide / administration & dosage. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Male. Oxonic Acid / administration & dosage. Paclitaxel / administration & dosage. Tegafur / administration & dosage

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  • (PMID = 16835491.001).
  • [ISSN] 0385-0684
  • [Journal-full-title] Gan to kagaku ryoho. Cancer & chemotherapy
  • [ISO-abbreviation] Gan To Kagaku Ryoho
  • [Language] jpn
  • [Publication-type] Case Reports; English Abstract; Journal Article
  • [Publication-country] Japan
  • [Chemical-registry-number] 0 / Drug Combinations; 150863-82-4 / S 1 (combination); 1548R74NSZ / Tegafur; 5VT6420TIG / Oxonic Acid; 6PLQ3CP4P3 / Etoposide; 7673326042 / irinotecan; P88XT4IS4D / Paclitaxel; Q20Q21Q62J / Cisplatin; XT3Z54Z28A / Camptothecin
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30. Liang YY, Dai YP, Cao MX, Zheng KL: [Diagnosis and therapy of metastatic tumors in the adrenal gland--a report of 21 cases]. Ai Zheng; 2006 Oct;25(10):1275-8
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  • [Title] [Diagnosis and therapy of metastatic tumors in the adrenal gland--a report of 21 cases].
  • BACKGROUND & OBJECTIVE: Recently, the occurrence of metastasis to the adrenal gland is increasing, while the early and differentiated diagnosis still remains difficult.
  • Whether metastasis to the adrenal gland needs to be resected and when and how the resection should be done are controversial.
  • This study was to explore the surgical indications of metastasis to the adrenal gland and the role of laparoscopic adrenalectomy in the treatment of this disease.
  • METHODS: Clinical data of 21 patients with metastatic tumors in the adrenal gland, treated in Cancer Center of Sun Yat-sen University from Mar.
  • Literature of the diagnosis and therapy was reviewed.
  • RESULTS: The diagnosis rates of ultrasonography and spiral or thin-cut computed tomography (CT) were 70.0% (7/10) and 84.6% (11/13).
  • CONCLUSIONS: Ultrasonography and CT are important diagnosis methods for metastatic adrenal cancer.
  • No evidence of tumor invasion revealed by preoperative imaging studies, no adjacent lymphadenopathy and no extraladrenal metastasis are indications of adrenalectomy.
  • [MeSH-major] Adrenal Gland Neoplasms / surgery. Adrenal Gland Neoplasms / ultrasonography. Adrenalectomy / methods. Laparoscopy

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  • (PMID = 17059775.001).
  • [Journal-full-title] Ai zheng = Aizheng = Chinese journal of cancer
  • [ISO-abbreviation] Ai Zheng
  • [Language] chi
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] China
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31. Lucchi M, Dini P, Ambrogi MC, Berti P, Materazzi G, Miccoli P, Mussi A: Metachronous adrenal masses in resected non-small cell lung cancer patients: therapeutic implications of laparoscopic adrenalectomy. Eur J Cardiothorac Surg; 2005 May;27(5):753-6
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  • [Title] Metachronous adrenal masses in resected non-small cell lung cancer patients: therapeutic implications of laparoscopic adrenalectomy.
  • OBJECTIVE: In literature only few reports focused on the resection of solitary adrenal gland metastasis in patients operated on for non-small cell lung cancer (NSCLC).
  • We report our experience on laparoscopic adrenalectomy for suspected or confirmed metachronous solitary adrenal metastasis from NSCLC and discuss its therapeutic role.
  • METHODS: From June 1993 to March 2003, 14 patients (pts), who had been undergone lung resection for NSCLC, with suspected or confirmed solitary adrenal gland metastasis at the follow-up, underwent 15 laparoscopic adrenalectomy (in 1 patient it was bilateral).
  • All the patients had enlarged adrenal glands at the abdominal ultrasound or CT.
  • All but 2 pts underwent at least 1 adrenal fine needle aspiration.
  • All the patients underwent a careful staging to exclude other sites of metastasis.
  • The adrenal gland was in 6 cases the right, in 9 cases the left.
  • RESULTS: In 7 cases we had a preoperative cytological diagnosis of metastasis.
  • The pathologic examination confirmed in 11 cases a NSCLC metastasis while in 4 cases it was a cortical adenoma.
  • Even though this series is still too small, laparoscopic adrenalectomy should be considered an effective therapeutic tool in case of progressive adrenal gland enlargement, also with negative cytological examinations.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Adrenalectomy / methods. Carcinoma, Non-Small-Cell Lung / secondary. Carcinoma, Non-Small-Cell Lung / surgery. Lung Neoplasms / surgery


32. Raynaud CM, Mercier O, Commo F, Dartevelle P, Gomez-Roca C, de Montpreville V, Sabatier L, Soria JC: Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases. Lung Cancer; 2009 Aug;65(2):144-9
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  • [Title] Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases.
  • INTRODUCTION: The development of molecular targeted therapies as anti-cancer strategies raises important questions regarding the biological and molecular behavior of the metastatic sites as compared to their corresponding primary tumors.
  • We analysed telomere related markers (telomere length and telomeric proteins) and DNA damage repair (DDR) markers in a cohort of patients with surgically resected primary lung NSCLC and adrenal metastasis.
  • MATERIAL AND METHODS: We studied a single series of 21 patients who had undergone surgery of both their primary lung tumor and its related adrenal gland metastasis in a single Institution.
  • RESULTS: DDR activation was observed in primary tumors and their corresponding metastasis.
  • However, higher levels of p-Chk2 were observed in metastasis than in primary tumors (p=0.0113).
  • Telomere length was independent from primary or metastatic status (p=0.29).
  • There was no correlation between primary and metastatic sites, although approximately 65% of metastases had shorter telomeres than their corresponding primary tumors.
  • In the same way, telomeric protein expression was independent from primary/metastatic localization.
  • Cluster analysis of each specimen according to its protein's expression levels and telomere length showed that matched primary tumors/adrenal metastasis were mostly separated into different clusters.
  • [MeSH-major] Adrenal Gland Neoplasms / metabolism. Biomarkers, Tumor / analysis. DNA Repair / physiology. DNA Repair Enzymes / metabolism. Lung Neoplasms / metabolism. Telomere / metabolism
  • [MeSH-minor] Adult. Aged. Carcinoma, Non-Small-Cell Lung / genetics. Carcinoma, Non-Small-Cell Lung / secondary. Cluster Analysis. Female. Humans. Immunohistochemistry. In Situ Hybridization, Fluorescence. Male. Middle Aged. Neoplasm Staging

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  • (PMID = 19091442.001).
  • [ISSN] 1872-8332
  • [Journal-full-title] Lung cancer (Amsterdam, Netherlands)
  • [ISO-abbreviation] Lung Cancer
  • [Language] eng
  • [Publication-type] Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Ireland
  • [Chemical-registry-number] 0 / Biomarkers, Tumor; EC 6.5.1.- / DNA Repair Enzymes
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33. Szendröi A, Szendröi M, Szücs M, Székely E, Romics I: 11-year survival of a renal cell cancer patient following multiple metastasectomy. Can J Urol; 2010 Dec;17(6):5475-7
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  • [Title] 11-year survival of a renal cell cancer patient following multiple metastasectomy.
  • CASE REPORT: A renal cell cancer patient with late onset of multiorgan metastases showed an unusually long survival following surgical resection.
  • Femoral metastasis appeared 11 years, and contra lateral kidney and adrenal gland metastasis 19 years after the primary nephrectomy, respectively.
  • Following the resection of the femur and implantation of endoprosthesis and removal of adrenal gland and partial nephrectomy, the patient was disease-free 20 years after the first diagnosis of cancer.
  • CONCLUSION: The long survival and successful treatment underline the importance and efficiency of radical metastasectomy even in the case of late onset multiorgan metastases of renal cell cancer.
  • The life expectancies are better in the late onset of bone metastasis following the nephrectomy.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Bone Neoplasms / secondary. Bone Neoplasms / surgery. Carcinoma, Renal Cell / pathology. Kidney Neoplasms / secondary
  • [MeSH-minor] Critical Pathways. Femur / pathology. Femur / surgery. Humans. Male. Middle Aged. Neoplasm Metastasis

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  • (PMID = 21172114.001).
  • [ISSN] 1195-9479
  • [Journal-full-title] The Canadian journal of urology
  • [ISO-abbreviation] Can J Urol
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Canada
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34. Qin MW, Pan WD, Cong GN, Wang Y, Zhang YQ, Mou WB, Jin ZY: Using of multislice helical CT colonography in patients with malignant lesions of colon. Chin Med Sci J; 2005 Sep;20(3):171-5

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  • [Title] Using of multislice helical CT colonography in patients with malignant lesions of colon.
  • METHODS: Fifty-nine patients with malignant lesions of colon underwent volume scanning using multislice helical CT.
  • The lesions' number, size, location, morphology, stricture of intestinal cavity, infiltration, and metastasis were shown satisfactorily by multislice helical CT colonography.
  • CT colonography displayed 4 synchronous colonic tumors, 1 ascending colon carcinoma combined with left renal carcinoma among 54 patients with colonic carcinomas.
  • CT colonography also displayed the infiltration of serous layer and fatty tissue in 45 cases; 21 cases matched the pathological results in all the 24 cases of suspicious lymph node metastasis, the sensitivity was 87.5%, the specificity was 90.6%; 9 cases hepatic metastasis, 2 ovarian metastasis, and 1 double adrenal gland metastasis.
  • CONCLUSIONS: Multislice helical CT colonography is effective in preoperative diagnosis, location, stage, and making treatment plan of colorectal carcinoma.

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  • (PMID = 16261887.001).
  • [ISSN] 1001-9294
  • [Journal-full-title] Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
  • [ISO-abbreviation] Chin. Med. Sci. J.
  • [Language] ENG
  • [Publication-type] Journal Article
  • [Publication-country] China
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35. Komai Y, Fujii Y, Kijima T, Suyama T, Okubo Y, Yamamoto S, Yonese J, Fukui I: [Significance of ipsilateral adrenalectomy in surgery for renal cell carcinoma]. Nihon Hinyokika Gakkai Zasshi; 2010 May;101(4):592-6
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  • [Title] [Significance of ipsilateral adrenalectomy in surgery for renal cell carcinoma].
  • PURPOSE: The aim of this study is to analyze the incidence of involvement of ipsilateral adrenal gland from renal cell carcinoma and assess the actual significance of ipsilateral adrenalectomy at nephrectomy.
  • PATIENTS AND METHODS: From 1981 to 2007, 588 patients were diagnosed as having renal cell carcinoma pathologically at our institution.
  • Of those patients, we retrospectively reviewed the clinicopathologic data in the 426 renal cell carcinoma patients who were eligible for evaluation.
  • RESULTS: Five patients (2.6%) of AD group had adrenal involvement and all of them presented T4 and/or M1 disease.
  • The three patients presented direct involvement of adrenal gland, while metastasis in the remaining 2.
  • The ipsilateral adrenal gland was abnormal on preoperative computed tomography (CT) in 8 patients (1.8%), of whom, 4 had adrenal involvement.
  • One of the five adrenal involvements was overlooked by CT.
  • The 18 patients (7.7%) in AS group later developed nodal and/or visceral metastasis, while no solitary ipsilateral adrenal recurrence was observed in this group.
  • CONCLUSIONS: Ipsilateral adrenal involvement from renal cell carcinoma is rare, especially after the adrenal-sparing surgery.
  • [MeSH-major] Adrenal Gland Neoplasms / pathology. Adrenal Gland Neoplasms / secondary. Adrenal Gland Neoplasms / surgery. Adrenalectomy. Carcinoma, Renal Cell / surgery. Kidney Neoplasms / surgery
  • [MeSH-minor] Aged. Female. Humans. Male. Middle Aged. Neoplasm Invasiveness. Nephrectomy. Prognosis. Sensitivity and Specificity. Tomography, X-Ray Computed

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  • (PMID = 20535986.001).
  • [ISSN] 0021-5287
  • [Journal-full-title] Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology
  • [ISO-abbreviation] Nippon Hinyokika Gakkai Zasshi
  • [Language] jpn
  • [Publication-type] English Abstract; Journal Article
  • [Publication-country] Japan
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36. Sung YM, Lee KS, Kim BT, Choi JY, Chung MJ, Shim YM, Yi CA, Kim TS: (18)F-FDG PET versus (18)F-FDG PET/CT for adrenal gland lesion characterization: a comparison of diagnostic efficacy in lung cancer patients. Korean J Radiol; 2008 Jan-Feb;9(1):19-28
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  • [Title] (18)F-FDG PET versus (18)F-FDG PET/CT for adrenal gland lesion characterization: a comparison of diagnostic efficacy in lung cancer patients.
  • OBJECTIVE: The aim of this study was to assess the diagnostic efficacy of integrated PET/CT using fluorodeoxyglucose (FDG) for the differentiation of benign and metastatic adrenal gland lesions in patients with lung cancer and to compare the diagnostic efficacy with the use of PET alone.
  • MATERIALS AND METHODS: Sixty-one adrenal lesions (size range, 5-104 mm; mean size, 16 mm) were evaluated retrospectively in 42 lung cancer patients.
  • PET findings were interpreted as positive if the FDG uptake of adrenal lesions was greater than or equal to that of the liver, and the PET/CT findings were interpreted as positive if an adrenal lesion show attenuation > 10 HU and showed increased FDG uptake.
  • Final diagnoses of adrenal gland lesions were made at clinical follow-up (n = 52) or by a biopsy (n = 9) when available.
  • The diagnostic accuracies of PET and PET/CT for the characterization of adrenal lesions were compared using the McNemar test.
  • RESULTS: Thirty-five (57%) of the 61 adrenal lesions were metastatic and the remaining 26 lesions were benign.
  • For the depiction of adrenal gland metastasis, the sensitivity, specificity, and accuracy of PET were 74%, 73%, and 74%, respectively, whereas those of integrated PET/CT were 80%, 89%, and 84%, respectively (p values; 0.5, 0.125, and 0.031, respectively).
  • CONCLUSION: The use of integrated PET/CT is more accurate than the use of PET alone for differentiating benign and metastatic adrenal gland lesions in lung cancer patients.
  • [MeSH-major] Adrenal Gland Neoplasms / radiography. Adrenal Gland Neoplasms / radionuclide imaging. Fluorodeoxyglucose F18. Lung Neoplasms / radiography. Lung Neoplasms / radionuclide imaging. Positron-Emission Tomography / methods. Radiopharmaceuticals. Tomography, X-Ray Computed / methods
  • [MeSH-minor] Adult. Aged. Biopsy. Diagnosis, Differential. Female. Humans. Male. Middle Aged. Retrospective Studies. Sensitivity and Specificity

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  • (PMID = 18253072.001).
  • [ISSN] 1229-6929
  • [Journal-full-title] Korean journal of radiology
  • [ISO-abbreviation] Korean J Radiol
  • [Language] eng
  • [Publication-type] Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • [Publication-country] Korea (South)
  • [Chemical-registry-number] 0 / Radiopharmaceuticals; 0Z5B2CJX4D / Fluorodeoxyglucose F18
  • [Other-IDs] NLM/ PMC2627169
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37. Mena Bares L, Gámez Cenzano C, Andía Navarro E, Palmero Sánchez R, Fernández León A, Pifarré Montaner P: [Metachronous suprarenal metastasis of non-microcytic lung cancer in a patient with bilateral adrenal adenomas]. Rev Esp Med Nucl; 2008 Sep-Oct;27(5):370-1
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  • [Title] [Metachronous suprarenal metastasis of non-microcytic lung cancer in a patient with bilateral adrenal adenomas].
  • [Transliterated title] Metástasis suprarrenal metacrónica de cáncer de pulmón no microcítico en paciente con adenomas adrenales bilaterales.
  • [MeSH-major] Adenoma / radionuclide imaging. Adrenal Gland Neoplasms / radionuclide imaging. Adrenal Gland Neoplasms / secondary. Carcinoma, Non-Small-Cell Lung / radionuclide imaging. Carcinoma, Non-Small-Cell Lung / secondary. Lung Neoplasms / pathology. Lung Neoplasms / radionuclide imaging


38. Moroni AL, Bricault I, Serra-Tosio G, Sengel C, Ferretti G: [Failure to characterize a suprarenal metastasis of hepatocarcinoma using the percentage of contrast medium washout with CT: a case study]. J Radiol; 2007 Apr;88(4):589-91
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  • [Title] [Failure to characterize a suprarenal metastasis of hepatocarcinoma using the percentage of contrast medium washout with CT: a case study].
  • [Transliterated title] Echec de caractérisation d'une métastase surrénalienne d'hépatocarcinome par le pourcentage de lavage du produit de contraste en TDM: à propos d'un cas.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Carcinoma, Hepatocellular / secondary. Contrast Media. Liver Neoplasms / pathology. Tomography, X-Ray Computed
  • [MeSH-minor] Adenoma / diagnosis. Aged. Biopsy. Diagnosis, Differential. Humans. Male. Palliative Care

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  • (PMID = 17464259.001).
  • [ISSN] 0221-0363
  • [Journal-full-title] Journal de radiologie
  • [ISO-abbreviation] J Radiol
  • [Language] fre
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] France
  • [Chemical-registry-number] 0 / Contrast Media
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39. Gerke H, Robinson RA, Luo P: Diagnosis of focal metastasis to the adrenal gland by EUS-guided core biopsy. Gastrointest Endosc; 2005 Sep;62(3):469-71
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  • [Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.
  • [Title] Diagnosis of focal metastasis to the adrenal gland by EUS-guided core biopsy.
  • [MeSH-major] Adenocarcinoma / secondary. Adrenal Gland Neoplasms / pathology. Biopsy, Needle / methods. Endosonography. Lung Neoplasms / pathology
  • [MeSH-minor] Aged. Antineoplastic Combined Chemotherapy Protocols / therapeutic use. Biopsy, Fine-Needle / methods. Disease Progression. Fatal Outcome. Humans. Immunohistochemistry. Male. Neoplasm Staging. Palliative Care

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  • (PMID = 16111980.001).
  • [ISSN] 0016-5107
  • [Journal-full-title] Gastrointestinal endoscopy
  • [ISO-abbreviation] Gastrointest. Endosc.
  • [Language] eng
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] United States
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40. Rodríguez-Hermosa JI, Roig J, Ortuño P, Quiles AM, Recasens M, Codina-Cazador A: [Adrenal metastasis from lung carcinoma]. Rev Esp Enferm Dig; 2008 Jan;100(1):45-6
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  • [Title] [Adrenal metastasis from lung carcinoma].
  • [Transliterated title] Metástasis adrenal de carcinoma pulmonar.
  • [MeSH-major] Adrenal Gland Neoplasms / secondary. Carcinoma, Squamous Cell / secondary. Lung Neoplasms / pathology

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  • (PMID = 18358060.001).
  • [ISSN] 1130-0108
  • [Journal-full-title] Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva
  • [ISO-abbreviation] Rev Esp Enferm Dig
  • [Language] spa
  • [Publication-type] Case Reports; Journal Article
  • [Publication-country] Spain
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41. Lee MK, Kwon CG, Hwang KH, Choe W, Kim JE, Tchah H, Jeon IS: F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child. Clin Nucl Med; 2009 Feb;34(2):107-8
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  • [Title] F-18 FDG PET/CT findings in a case of undifferentiated embryonal sarcoma of the liver with lung and adrenal gland metastasis in a child.
  • [MeSH-major] Adrenal Gland Neoplasms / diagnosis. Adrenal Gland Neoplasms / secondary. Liver Neoplasms / pathology. Lung Neoplasms / diagnosis. Lung Neoplasms / secondary. Neoplasms, Germ Cell and Embryonal / pathology. Sarcoma / pathology






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